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Selumetinib og Akt-hæmmer MK2206 eller mFOLFOX-terapi omfattende oxaliplatin og fluorouracil til behandling af patienter med metastatisk kræft i bugspytkirtlen, der tidligere er behandlet med kemoterapi (S1115)

10. februar 2016 opdateret af: National Cancer Institute (NCI)

Randomiseret fase II klinisk forsøg med AZD6244 Hydrogensulfat (NSC-748727) og MK-2206 (NSC-749607) vs mFOLFOX hos patienter med metastatisk bugspytkirtelkræft efter forudgående kemoterapi

Dette randomiserede fase II-forsøg undersøger, hvor godt selumetinib og Akt-hæmmer MK2206 virker sammenlignet med modificeret fluorouracil, leucovorin calcium og oxaliplatin (mFOLFOX) behandling i behandling af patienter med metastatisk bugspytkirtelkræft tidligere behandlet med kemoterapi. Selumetinib og Akt-hæmmer MK2206 kan stoppe væksten af ​​tumorceller ved at blokere nogle af de enzymer, der er nødvendige for cellevækst. Lægemidler, der bruges i kemoterapi, såsom oxaliplatin og fluorouracil, virker på forskellige måder for at stoppe væksten af ​​tumorceller, enten ved at dræbe cellerne eller ved at forhindre dem i at dele sig. Det vides endnu ikke, om selumetinib og Akt-hæmmer MK2206 er mere effektive end oxaliplatin og fluorouracil til behandling af patienter med metastatisk bugspytkirtelkræft.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆRE MÅL:

I. At vurdere den samlede overlevelse hos patienter med metastatisk bugspytkirtelcancer behandlet med kombinationen af ​​AZD6244 hydrogensulfat (selumetinib) og MK-2206 (Akt-hæmmer MK2206) sammenlignet med dem behandlet med mFOLFOX.

SEKUNDÆRE MÅL:

I. At vurdere hyppigheden og sværhedsgraden af ​​toksicitet forbundet med kombinationen af ​​AZD6244 hydrogensulfat og MK-2206 sammenlignet med dem med mFOLFOX i denne patientpopulation.

TERTIÆRE MÅL:

I. At vurdere progressionsfri overlevelse (PFS) hos patienter med metastatisk bugspytkirtelcancer behandlet med kombinationen af ​​AZD6244 hydrogensulfat og MK-2206 sammenlignet med dem behandlet med mFOLFOX.

II. At vurdere objektiv tumorrespons i undergruppen af ​​patienter med målbar sygdom (bekræftet og ubekræftet fuldstændig og delvis respons) hos patienter med metastatisk bugspytkirtelcancer behandlet med kombinationen af ​​AZD6244 hydrogensulfat og MK-2206 sammenlignet med dem behandlet med mFOLFOX.

III. At banke væv og blod til fremtidige translationelle medicinstudier.

OVERSIGT: Patienterne randomiseres til 1 ud af 2 behandlingsarme.

ARM I: Patienter får oxaliplatin intravenøst ​​(IV) over 2 timer på dag 1 og 15 og fluorouracil IV over 46-48 timer på dag 1-2 og 15-16 (mFOLFOX).

ARM II: Patienter får Akt-hæmmer MK2206 oralt (PO) på dag 1, 8, 15 og 22, og selumetinib PO dagligt på dag 1-28.

I alle arme gentages kurser hver 28. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.

Efter afsluttet undersøgelsesbehandling følges patienterne hver 6. måned i op til 3 år.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

137

Fase

  • Fase 2

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Forenede Stater
    • Arizona
      • Tucson, Arizona, Forenede Stater, 85719
        • The University of Arizona Cancer Center-North Campus
      • Tucson, Arizona, Forenede Stater, 85704
        • The University of Arizona Cancer Center-Orange Grove Campus
    • Arkansas
      • Little Rock, Arkansas, Forenede Stater, 72205
        • University of Arkansas for Medical Sciences
    • California
      • Anaheim, California, Forenede Stater, 92807
        • Kaiser Permanente-Anaheim
      • Antioch, California, Forenede Stater, 94531
        • Kaiser Permanente-Deer Valley Medical Center
      • Baldwin Park, California, Forenede Stater, 91706
        • Kaiser Permanente-Baldwin Park
      • Bellflower, California, Forenede Stater, 90706
        • Kaiser Permanente-Bellflower
      • Berkeley, California, Forenede Stater, 94704
        • Alta Bates Summit Medical Center-Herrick Campus
      • Burlingame, California, Forenede Stater, 94010
        • Mills - Peninsula Hospitals
      • Castro Valley, California, Forenede Stater, 94546
        • East Bay Radiation Oncology Center
      • Castro Valley, California, Forenede Stater, 94546
        • Valley Medical Oncology Consultants-Castro Valley
      • Duarte, California, Forenede Stater, 91010
        • City of Hope Comprehensive Cancer Center
      • Dublin, California, Forenede Stater, 94568
        • Epic Care-Dublin
      • Emeryville, California, Forenede Stater, 94608
        • Bay Area Breast Surgeons Inc
      • Emeryville, California, Forenede Stater, 94608
        • Epic Care Partners in Cancer Care
      • Fontana, California, Forenede Stater, 92335
        • Kaiser Permanente Hospital
      • Fremont, California, Forenede Stater, 94538
        • Kaiser Permanente-Fremont
      • Fremont, California, Forenede Stater, 94538
        • Valley Medical Oncology Consultants-Fremont
      • Fresno, California, Forenede Stater, 93720
        • Kaiser Permanente
      • Fullerton, California, Forenede Stater, 92835
        • Saint Jude Medical Center
      • Harbor City, California, Forenede Stater, 90710
        • Kaiser Permanente - Harbor City
      • Irvine, California, Forenede Stater, 92618
        • Kaiser Permanente-Irvine
      • Los Angeles, California, Forenede Stater, 90033
        • USC / Norris Comprehensive Cancer Center
      • Los Angeles, California, Forenede Stater, 90048
        • Cedars-Sinai Medical Center
      • Los Angeles, California, Forenede Stater, 90033
        • Los Angeles County-USC Medical Center
      • Los Angeles, California, Forenede Stater, 90027
        • Kaiser Permanente Los Angeles Medical Center
      • Los Angeles, California, Forenede Stater, 90034
        • Kaiser Permanente-Cadillac
      • Martinez, California, Forenede Stater, 94553-3156
        • Contra Costa Regional Medical Center
      • Marysville, California, Forenede Stater, 95901
        • Fremont - Rideout Cancer Center
      • Merced, California, Forenede Stater, 95340
        • Mercy UC Davis Cancer Center
      • Modesto, California, Forenede Stater, 95356
        • Kaiser Permanente-Modesto
      • Mountain View, California, Forenede Stater, 94040
        • El Camino Hospital
      • Novato, California, Forenede Stater, 94945
        • Sutter Cancer Research Consortium
      • Oakland, California, Forenede Stater, 94611
        • Kaiser Permanente-Oakland
      • Oakland, California, Forenede Stater, 94609
        • Alta Bates Summit Medical Center - Summit Campus
      • Oakland, California, Forenede Stater, 94609
        • Hematology and Oncology Associates-Oakland
      • Oakland, California, Forenede Stater, 94602
        • Highland General Hospital
      • Oakland, California, Forenede Stater, 94609
        • Tom K Lee Inc
      • Oakland, California, Forenede Stater, 94609
        • Bay Area Tumor Institute
      • Orange, California, Forenede Stater, 92868
        • UC Irvine Health/Chao Family Comprehensive Cancer Center
      • Orange, California, Forenede Stater, 92868
        • Saint Joseph Hospital - Orange
      • Panorama City, California, Forenede Stater, 91402
        • Kaiser Permanente - Panorama City
      • Pleasant Hill, California, Forenede Stater, 94523
        • East Bay Medical Oncology Hematology Medical Associates Inc-Pleasant Hill
      • Pleasanton, California, Forenede Stater, 94588
        • Valley Medical Oncology Consultants
      • Redwood City, California, Forenede Stater, 94063
        • Kaiser Permanente-Redwood City
      • Richmond, California, Forenede Stater, 94801
        • Kaiser Permanente-Richmond
      • Riverside, California, Forenede Stater, 92505
        • Kaiser Permanente-Riverside
      • Roseville, California, Forenede Stater, 95661
        • Kaiser Permanente-Roseville
      • Sacramento, California, Forenede Stater, 95817
        • University of California Davis Comprehensive Cancer Center
      • Sacramento, California, Forenede Stater, 95823
        • Kaiser Permanente-South Sacramento
      • Sacramento, California, Forenede Stater, 95825
        • Kaiser Permanente - Sacramento
      • Saint Helena, California, Forenede Stater, 94574
        • Saint Helena Hospital
      • San Diego, California, Forenede Stater, 92120
        • Kaiser Permanente-San Diego Zion
      • San Diego, California, Forenede Stater, 92108
        • Kaiser Permanente-San Diego Mission
      • San Francisco, California, Forenede Stater, 94115
        • Kaiser Permanente-San Francisco
      • San Francisco, California, Forenede Stater, 94118
        • California Pacific Medical Center-Pacific Campus
      • San Jose, California, Forenede Stater, 95119
        • Kaiser Permanente-Santa Teresa-San Jose
      • San Leandro, California, Forenede Stater, 94577
        • Kaiser Permanente San Leandro
      • San Marcos, California, Forenede Stater, 92069
        • Kaiser Permanente-San Marcos
      • San Pablo, California, Forenede Stater, 94806
        • Doctors Medical Center- JC Robinson Regional Cancer Center
      • San Rafael, California, Forenede Stater, 94903
        • Kaiser Permanente-San Rafael
      • Santa Clara, California, Forenede Stater, 95051
        • Kaiser Permanente Medical Center - Santa Clara
      • Santa Rosa, California, Forenede Stater, 95403
        • Kaiser Permanente-Santa Rosa
      • Santa Rosa, California, Forenede Stater, 95403
        • Sutter Pacific Medical Foundation
      • South San Francisco, California, Forenede Stater, 94080
        • Kaiser Permanente-South San Francisco
      • Stockton, California, Forenede Stater, 95210
        • Kaiser Permanente-Stockton
      • Truckee, California, Forenede Stater, 96161
        • Tahoe Forest Cancer Center
      • Vacaville, California, Forenede Stater, 95688
        • Kaiser Permanente Medical Center-Vacaville
      • Vallejo, California, Forenede Stater, 94589
        • Kaiser Permanente-Vallejo
      • Vallejo, California, Forenede Stater, 94589
        • Sutter Solano Medical Center/Cancer Center
      • Walnut Creek, California, Forenede Stater, 94596
        • Kaiser Permanente-Walnut Creek
      • Woodland Hills, California, Forenede Stater, 91367
        • Kaiser Permanente
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80012
        • The Medical Center of Aurora
      • Boulder, Colorado, Forenede Stater, 80301
        • Boulder Community Hospital
      • Boulder, Colorado, Forenede Stater, 80304
        • Rocky Mountain Cancer Centers-Boulder
      • Colorado Springs, Colorado, Forenede Stater, 80907
        • Penrose-Saint Francis Healthcare
      • Colorado Springs, Colorado, Forenede Stater, 80907
        • Rocky Mountain Cancer Centers-Penrose
      • Denver, Colorado, Forenede Stater, 80210
        • Porter Adventist Hospital
      • Denver, Colorado, Forenede Stater, 80205
        • Kaiser Permanente-Franklin
      • Denver, Colorado, Forenede Stater, 80218
        • Presbyterian - Saint Lukes Medical Center - Health One
      • Denver, Colorado, Forenede Stater, 80220
        • Rose Medical Center
      • Denver, Colorado, Forenede Stater, 80218
        • Exempla Saint Joseph Hospital
      • Denver, Colorado, Forenede Stater, 80218
        • Rocky Mountain Cancer Centers-Midtown
      • Denver, Colorado, Forenede Stater, 80220
        • Rocky Mountain Cancer Centers-Rose
      • Denver, Colorado, Forenede Stater, 80218
        • Colorado Blood Cancer Institute
      • Denver, Colorado, Forenede Stater, 80224-2522
        • Colorado Cancer Research Program CCOP
      • Durango, Colorado, Forenede Stater, 81301
        • Mercy Medical Center
      • Englewood, Colorado, Forenede Stater, 80113
        • Swedish Medical Center
      • Englewood, Colorado, Forenede Stater, 80113
        • Comprehensive Cancer Care and Research Institute of Colorado LLC
      • Fort Collins, Colorado, Forenede Stater, 80524
        • Poudre Valley Hospital
      • Fort Collins, Colorado, Forenede Stater, 80528
        • Front Range Cancer Specialists
      • Golden, Colorado, Forenede Stater, 80401
        • Mountain Blue Cancer Care Center
      • Greeley, Colorado, Forenede Stater, 80631
        • North Colorado Medical Center
      • Greenwood Village, Colorado, Forenede Stater, 80111
        • Rocky Mountain Cancer Centers-Greenwood Village
      • Lafayette, Colorado, Forenede Stater, 80026
        • Kaiser Permanente-Rock Creek
      • Lakewood, Colorado, Forenede Stater, 80228
        • Saint Anthony Hospital
      • Lakewood, Colorado, Forenede Stater, 80228
        • Rocky Mountain Cancer Centers-Lakewood
      • Littleton, Colorado, Forenede Stater, 80122
        • Littleton Adventist Hospital
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Kaiser Permanente-Lone Tree
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Sky Ridge Medical Center
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Rocky Mountain Cancer Centers-Sky Ridge
      • Longmont, Colorado, Forenede Stater, 80501
        • Longmont United Hospital
      • Longmont, Colorado, Forenede Stater, 80501
        • Rocky Mountain Cancer Centers-Longmont
      • Loveland, Colorado, Forenede Stater, 80539
        • McKee Medical Center
      • Parker, Colorado, Forenede Stater, 80138
        • Parker Adventist Hospital
      • Parker, Colorado, Forenede Stater, 80138
        • Rocky Mountain Cancer Centers-Parker
      • Pueblo, Colorado, Forenede Stater, 81004
        • Saint Mary Corwin Medical Center
      • Pueblo, Colorado, Forenede Stater, 81008
        • Rocky Mountain Cancer Centers - Pueblo
      • Wheat Ridge, Colorado, Forenede Stater, 80033
        • SCL Health Lutheran Medical Center
    • Connecticut
      • Hartford, Connecticut, Forenede Stater, 06105
        • Saint Francis Hospital and Medical Center
      • Middletown, Connecticut, Forenede Stater, 06457
        • Middlesex Hospital
      • Stamford, Connecticut, Forenede Stater, 06904
        • Stamford Hospital/Bennett Cancer Center
    • Delaware
      • Lewes, Delaware, Forenede Stater, 19958
        • Beebe Medical Center
      • Newark, Delaware, Forenede Stater, 19713
        • Helen F Graham Cancer Center
      • Newark, Delaware, Forenede Stater, 19713
        • Delaware Clinical and Laboratory Physicians PA
      • Newark, Delaware, Forenede Stater, 19713
        • Medical Oncology Hematology Consultants PA
      • Newark, Delaware, Forenede Stater, 19718
        • Christiana Care Health System-Christiana Hospital
      • Newark, Delaware, Forenede Stater, 19713
        • Christiana Gynecologic Oncology LLC
      • Newark, Delaware, Forenede Stater, 19713
        • Regional Hematology and Oncology PA
      • Rehoboth Beach, Delaware, Forenede Stater, 19971
        • Beebe Health Campus
      • Seaford, Delaware, Forenede Stater, 19973
        • Nanticoke Memorial Hospital
      • Wilmington, Delaware, Forenede Stater, 19801
        • Christiana Care Health System-Wilmington Hospital
    • Florida
      • Jacksonville, Florida, Forenede Stater, 32207
        • Baptist Cancer Institute
      • Orlando, Florida, Forenede Stater, 32803
        • Florida Hospital Orlando
    • Georgia
      • Athens, Georgia, Forenede Stater, 30607
        • University Cancer and Blood Center LLC
      • Augusta, Georgia, Forenede Stater, 30912
        • Georgia Regents University Medical Center
      • Decatur, Georgia, Forenede Stater, 30033
        • Dekalb Medical Center
      • Gainesville, Georgia, Forenede Stater, 30501
        • Northeast Georgia Medical Center
      • Macon, Georgia, Forenede Stater, 31208
        • Medical Center of Central Georgia
      • Savannah, Georgia, Forenede Stater, 31405
        • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
      • Valdosta, Georgia, Forenede Stater, 31603
        • South Georgia Medical Center
    • Hawaii
      • Aiea, Hawaii, Forenede Stater, 96701
        • Oncare Hawaii Inc-Pali Momi
      • Aiea, Hawaii, Forenede Stater, 96701
        • Pali Momi Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Queen's Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Straub Clinic and Hospital
      • Honolulu, Hawaii, Forenede Stater, 96813
        • University of Hawaii Cancer Center
      • Honolulu, Hawaii, Forenede Stater, 96819
        • Kaiser Permanente Moanalua Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Oncare Hawaii Inc-POB II
      • Honolulu, Hawaii, Forenede Stater, 96817-3169
        • OnCare Hawaii-Liliha
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Oncare Hawaii Inc-Kuakini
      • Kailua, Hawaii, Forenede Stater, 96734
        • Castle Medical Center
      • Lihue, Hawaii, Forenede Stater, 96766
        • Wilcox Memorial Hospital and Kauai Medical Clinic
    • Idaho
      • Boise, Idaho, Forenede Stater, 83706
        • Saint Alphonsus Cancer Care Center-Boise
      • Meridian, Idaho, Forenede Stater, 83642
        • Idaho Urologic Institute-Meridian
      • Post Falls, Idaho, Forenede Stater, 83854
        • Kootenai Cancer Center
    • Illinois
      • Aurora, Illinois, Forenede Stater, 60504
        • Rush - Copley Medical Center
      • Carbondale, Illinois, Forenede Stater, 62902
        • Memorial Hospital of Carbondale
      • Centralia, Illinois, Forenede Stater, 62801
        • Centralia Oncology Clinic
      • Chicago, Illinois, Forenede Stater, 60611
        • Northwestern University
      • Chicago, Illinois, Forenede Stater, 60612
        • Rush University Medical Center
      • Chicago, Illinois, Forenede Stater, 60637
        • University of Chicago Comprehensive Cancer Center
      • Chicago, Illinois, Forenede Stater, 60612
        • University of Illinois
      • Chicago, Illinois, Forenede Stater, 60640
        • Weiss Memorial Hospital
      • Decatur, Illinois, Forenede Stater, 62526
        • Decatur Memorial Hospital
      • Decatur, Illinois, Forenede Stater, 62526
        • Cancer Care Center of Decatur
      • Decatur, Illinois, Forenede Stater, 62526
        • Central Illinois CCOP
      • Effingham, Illinois, Forenede Stater, 62401
        • Crossroads Cancer Center
      • Elgin, Illinois, Forenede Stater, 60123
        • Advocate Sherman Hospital
      • Harvey, Illinois, Forenede Stater, 60426
        • Ingalls Memorial Hospital
      • Highland Park, Illinois, Forenede Stater, 60035
        • Hematology Oncology Associates of Illinois-Highland Park
      • Joliet, Illinois, Forenede Stater, 60435
        • Joliet Oncology-Hematology Associates Limited
      • Kankakee, Illinois, Forenede Stater, 60901
        • Presence Saint Mary's Hospital
      • Libertyville, Illinois, Forenede Stater, 60048
        • NorthShore Hematology Oncology-Libertyville
      • Maywood, Illinois, Forenede Stater, 60153
        • Loyola University Medical Center
      • Mount Vernon, Illinois, Forenede Stater, 62864
        • Good Samaritan Regional Health Center
      • Niles, Illinois, Forenede Stater, 60714
        • Illinois Cancer Specialists-Niles
      • River Forest, Illinois, Forenede Stater, 60305
        • West Suburban Medical Center
      • Skokie, Illinois, Forenede Stater, 60076
        • Hematology Oncology Associates of Illinois - Skokie
      • Springfield, Illinois, Forenede Stater, 62781
        • Memorial Medical Center
      • Urbana, Illinois, Forenede Stater, 61801
        • Carle Cancer Center
    • Indiana
      • Beech Grove, Indiana, Forenede Stater, 46107
        • Franciscan St. Francis Health-Beech Grove
      • Elkhart, Indiana, Forenede Stater, 46515
        • Elkhart General Hospital
      • Elkhart, Indiana, Forenede Stater, 46514
        • Michiana Hematology Oncology PC-Elkhart
      • Elkhart, Indiana, Forenede Stater, 46514-2098
        • Elkhart Clinic
      • Fort Wayne, Indiana, Forenede Stater, 46845
        • Fort Wayne Medical Oncology and Hematology Inc-Parkview
      • Indianapolis, Indiana, Forenede Stater, 46202
        • Indiana University/Melvin and Bren Simon Cancer Center
      • Indianapolis, Indiana, Forenede Stater, 46219
        • IU Health Central Indiana Cancer Centers-East
      • Indianapolis, Indiana, Forenede Stater, 46237
        • Franciscan Saint Francis Health-Indianapolis
      • Kokomo, Indiana, Forenede Stater, 46904
        • Community Howard Regional Health
      • La Porte, Indiana, Forenede Stater, 46350
        • IU Health La Porte Hospital
      • Michigan City, Indiana, Forenede Stater, 46360
        • Franciscan Saint Anthony Health-Michigan City
      • Mishawaka, Indiana, Forenede Stater, 46545
        • Michiana Hematology Oncology PC-Mishawaka
      • Mishawaka, Indiana, Forenede Stater, 46545
        • Cancer Care Partners LLC
      • Mishawaka, Indiana, Forenede Stater, 46545
        • Saint Joseph Regional Medical Center-Mishawaka
      • Plymouth, Indiana, Forenede Stater, 46563
        • Michiana Hematology Oncology PC-Plymouth
      • Richmond, Indiana, Forenede Stater, 47374
        • Reid Hospital and Health Care Services
      • South Bend, Indiana, Forenede Stater, 46601
        • Memorial Hospital of South Bend
      • South Bend, Indiana, Forenede Stater, 46601
        • Michiana Hematology Oncology PC-South Bend
      • South Bend, Indiana, Forenede Stater, 46617
        • South Bend Clinic
      • South Bend, Indiana, Forenede Stater, 46628
        • Northern Indiana Cancer Research Consortium CCOP
      • Westville, Indiana, Forenede Stater, 46391
        • Michiana Hematology Oncology PC-Westville
    • Iowa
      • Bettendorf, Iowa, Forenede Stater, 52722
        • Hematology Oncology Associates-Quad Cities
      • Davenport, Iowa, Forenede Stater, 52803
        • Genesis Medical Center - East Campus
      • Sioux City, Iowa, Forenede Stater, 51101
        • Siouxland Regional Cancer Center
      • Sioux City, Iowa, Forenede Stater, 51104
        • Saint Luke's Regional Medical Center
      • Sioux City, Iowa, Forenede Stater, 51104
        • Mercy Medical Center-Sioux City
    • Kansas
      • Chanute, Kansas, Forenede Stater, 66720
        • Cancer Center of Kansas - Chanute
      • Dodge City, Kansas, Forenede Stater, 67801
        • Cancer Center of Kansas - Dodge City
      • El Dorado, Kansas, Forenede Stater, 67042
        • Cancer Center of Kansas - El Dorado
      • Fort Scott, Kansas, Forenede Stater, 66701
        • Cancer Center of Kansas - Fort Scott
      • Independence, Kansas, Forenede Stater, 67301
        • Cancer Center of Kansas-Independence
      • Kansas City, Kansas, Forenede Stater, 66112
        • Providence Medical Center
      • Kingman, Kansas, Forenede Stater, 67068
        • Cancer Center of Kansas-Kingman
      • Lawrence, Kansas, Forenede Stater, 66044
        • Lawrence Memorial Hospital
      • Liberal, Kansas, Forenede Stater, 67901
        • Cancer Center of Kansas-Liberal
      • Manhattan, Kansas, Forenede Stater, 66502
        • Cancer Center of Kansas-Manhattan
      • McPherson, Kansas, Forenede Stater, 67460
        • Cancer Center of Kansas - McPherson
      • Newton, Kansas, Forenede Stater, 67114
        • Cancer Center of Kansas - Newton
      • Overland Park, Kansas, Forenede Stater, 66209
        • Menorah Medical Center
      • Overland Park, Kansas, Forenede Stater, 66213
        • Saint Luke's South Hospital
      • Parsons, Kansas, Forenede Stater, 67357
        • Cancer Center of Kansas - Parsons
      • Prairie Village, Kansas, Forenede Stater, 66208
        • Kansas City CCOP
      • Pratt, Kansas, Forenede Stater, 67124
        • Cancer Center of Kansas - Pratt
      • Salina, Kansas, Forenede Stater, 67401
        • Cancer Center of Kansas - Salina
      • Wellington, Kansas, Forenede Stater, 67152
        • Cancer Center of Kansas - Wellington
      • Wichita, Kansas, Forenede Stater, 67208
        • Cancer Center of Kansas-Wichita Medical Arts Tower
      • Wichita, Kansas, Forenede Stater, 67208
        • Associates In Womens Health
      • Wichita, Kansas, Forenede Stater, 67214
        • Cancer Center of Kansas - Main Office
      • Wichita, Kansas, Forenede Stater, 67214
        • Via Christi Regional Medical Center
      • Wichita, Kansas, Forenede Stater, 67214
        • Wichita CCOP
      • Winfield, Kansas, Forenede Stater, 67156
        • Cancer Center of Kansas - Winfield
    • Kentucky
      • Crestview Hills, Kentucky, Forenede Stater, 41017
        • Oncology Hematology Care Inc-Crestview
    • Louisiana
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Mary Bird Perkins Cancer Center
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Ochsner Health Center-Summa
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Hematology/Oncology Clinic LLP
      • Lafayette, Louisiana, Forenede Stater, 70503
        • Cancer Center of Acadiana
      • Mansfield, Louisiana, Forenede Stater, 71052
        • DeSoto Regional Health System
      • Monroe, Louisiana, Forenede Stater, 71202
        • University Health-Conway
      • New Orleans, Louisiana, Forenede Stater, 70121
        • Ochsner Medical Center Jefferson
      • New Orleans, Louisiana, Forenede Stater, 70112
        • Tulane University Health Sciences Center
      • New Orleans, Louisiana, Forenede Stater, 70112
        • Louisiana State University Health Science Center
      • New Orleans, Louisiana, Forenede Stater, 70115
        • Ochsner Baptist Medical Center
      • Shreveport, Louisiana, Forenede Stater, 71103
        • Louisiana State University Health Sciences Center Shreveport
      • Shreveport, Louisiana, Forenede Stater, 71105
        • Highland Clinic
    • Maine
      • Augusta, Maine, Forenede Stater, 04330
        • Harold Alfond Center for Cancer Care
      • Bangor, Maine, Forenede Stater, 04401
        • Eastern Maine Medical Center
    • Maryland
      • Elkton MD, Maryland, Forenede Stater, 21921
        • Union Hospital of Cecil County
    • Michigan
      • Adrian, Michigan, Forenede Stater, 49221
        • Bixby Medical Center
      • Adrian, Michigan, Forenede Stater, 49221
        • Hickman Cancer Center
      • Ann Arbor, Michigan, Forenede Stater, 48106-0995
        • Saint Joseph Mercy Hospital
      • Ann Arbor, Michigan, Forenede Stater, 48106
        • Michigan Cancer Research Consortium CCOP
      • Ann Arbor, Michigan, Forenede Stater, 48109
        • University of Michigan Comprehensive Cancer Center
      • Battle Creek, Michigan, Forenede Stater, 49017
        • Bronson Battle Creek
      • Big Rapids, Michigan, Forenede Stater, 49307
        • Spectrum Health Big Rapids Hospital
      • Commerce, Michigan, Forenede Stater, 48382
        • Huron Valley-Sinai Hospital
      • Dearborn, Michigan, Forenede Stater, 48124
        • Oakwood Hospital and Medical Center
      • Detroit, Michigan, Forenede Stater, 48236
        • Saint John Hospital and Medical Center
      • Detroit, Michigan, Forenede Stater, 48201
        • Wayne State University/Karmanos Cancer Institute
      • Flint, Michigan, Forenede Stater, 48502
        • Hurley Medical Center
      • Flint, Michigan, Forenede Stater, 48503
        • Genesys Hurley Cancer Institute
      • Grand Blanc, Michigan, Forenede Stater, 48439
        • Genesys Regional Medical Center
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Spectrum Health at Butterworth Campus
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Mercy Health Saint Mary's
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Grand Rapids Clinical Oncology Program
      • Jackson, Michigan, Forenede Stater, 49201
        • Allegiance Health
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • West Michigan Cancer Center
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • Bronson Methodist Hospital
      • Kalamazoo, Michigan, Forenede Stater, 49001
        • Borgess Medical Center
      • Lansing, Michigan, Forenede Stater, 48912
        • Sparrow Hospital
      • Livonia, Michigan, Forenede Stater, 48154
        • Saint Mary Mercy Hospital
      • Monroe, Michigan, Forenede Stater, 48162
        • Mercy Memorial Hospital
      • Monroe, Michigan, Forenede Stater, 48162
        • Toledo Clinic Cancer Centers-Monroe
      • Muskegon, Michigan, Forenede Stater, 49444
        • Mercy Health Mercy Campus
      • Pontiac, Michigan, Forenede Stater, 48341
        • Saint Joseph Mercy Oakland
      • Port Huron, Michigan, Forenede Stater, 48060
        • Saint Joseph Mercy Port Huron
      • Reed City, Michigan, Forenede Stater, 49677
        • Spectrum Health Reed City Hospital
      • Saginaw, Michigan, Forenede Stater, 48601
        • Saint Mary's of Michigan
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Marie Yeager Cancer Center
      • Southfield, Michigan, Forenede Stater, 48075
        • Providence Hospital-Southfield Cancer Center
      • St. Joseph, Michigan, Forenede Stater, 49085
        • Lakeland Hospital
      • Traverse City, Michigan, Forenede Stater, 49684
        • Munson Medical Center
      • Warren, Michigan, Forenede Stater, 48093
        • Saint John Macomb-Oakland Hospital
    • Minnesota
      • Bemidji, Minnesota, Forenede Stater, 56601
        • Sanford Clinic North-Bemidgi
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Fairview Ridges Hospital
      • Coon Rapids, Minnesota, Forenede Stater, 55433
        • Mercy Hospital
      • Edina, Minnesota, Forenede Stater, 55435
        • Fairview-Southdale Hospital
      • Fridley, Minnesota, Forenede Stater, 55432
        • Unity Hospital
      • Hutchinson, Minnesota, Forenede Stater, 55350
        • Hutchinson Area Health Care
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Saint John's Hospital - Healtheast
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Minnesota Oncology Hematology PA-Maplewood
      • Minneapolis, Minnesota, Forenede Stater, 55415
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Abbott-Northwestern Hospital
      • New Ulm, Minnesota, Forenede Stater, 56073
        • New Ulm Medical Center
      • Robbinsdale, Minnesota, Forenede Stater, 55422
        • North Memorial Medical Health Center
      • Saint Cloud, Minnesota, Forenede Stater, 56303
        • Coborn Cancer Center at Saint Cloud Hospital
      • Saint Cloud, Minnesota, Forenede Stater, 56303
        • Saint Cloud Hospital
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Metro Minnesota Community Oncology Research Consortium
      • Saint Paul, Minnesota, Forenede Stater, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • United Hospital
      • Shakopee, Minnesota, Forenede Stater, 55379
        • Saint Francis Regional Medical Center
      • Stillwater, Minnesota, Forenede Stater, 55082
        • Lakeview Hospital
      • Waconia, Minnesota, Forenede Stater, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, Forenede Stater, 56201
        • Rice Memorial Hospital
      • Woodbury, Minnesota, Forenede Stater, 55125
        • Minnesota Oncology and Hematology PA-Woodbury
    • Mississippi
      • Jackson, Mississippi, Forenede Stater, 39216
        • University of Mississippi Medical Center
    • Missouri
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Saint Francis Medical Center
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Southeast Cancer Center
      • Columbia, Missouri, Forenede Stater, 65212
        • University of Missouri - Ellis Fischel
      • Independence, Missouri, Forenede Stater, 64057
        • Centerpoint Medical Center LLC
      • Jefferson City, Missouri, Forenede Stater, 65109
        • Capital Region Medical Center-Goldschmidt Cancer Center
      • Kansas City, Missouri, Forenede Stater, 64128
        • Kansas City Veterans Affairs Medical Center
      • Kansas City, Missouri, Forenede Stater, 64116
        • North Kansas City Hospital
      • Kansas City, Missouri, Forenede Stater, 64111
        • Saint Luke's Hospital of Kansas City
      • Kansas City, Missouri, Forenede Stater, 64132
        • Research Medical Center
      • Kansas City, Missouri, Forenede Stater, 64118
        • Heartland Hematology and Oncology Associates Incorporated
      • Lee's Summit, Missouri, Forenede Stater, 64086
        • Saint Luke's East - Lee's Summit
      • Liberty, Missouri, Forenede Stater, 64068
        • Liberty Radiation Oncology Center
      • Rolla, Missouri, Forenede Stater, 65401
        • Phelps County Regional Medical Center
      • Rolla, Missouri, Forenede Stater, 65401
        • Saint John's Clinic-Rolla-Cancer and Hematology
      • Saint Joseph, Missouri, Forenede Stater, 64506
        • Heartland Regional Medical Center
      • Saint Joseph, Missouri, Forenede Stater, 64507
        • Saint Joseph Oncology Inc
      • Saint Louis, Missouri, Forenede Stater, 63110
        • Washington University School of Medicine
      • Saint Louis, Missouri, Forenede Stater, 63131
        • Missouri Baptist Medical Center
      • Saint Louis, Missouri, Forenede Stater, 63141
        • Mercy Hospital Saint Louis
      • Saint Louis, Missouri, Forenede Stater, 63109
        • Saint Louis Cancer and Breast Institute-South City
      • Springfield, Missouri, Forenede Stater, 65804
        • Cancer Research for the Ozarks NCORP
      • Springfield, Missouri, Forenede Stater, 65807
        • CoxHealth South Hospital
      • Springfield, Missouri, Forenede Stater, 65804
        • Mercy Hospital Springfield
    • Montana
      • Billings, Montana, Forenede Stater, 59101
        • Saint Vincent Healthcare
      • Billings, Montana, Forenede Stater, 59102
        • Frontier Cancer Center and Blood Institute-Billings
      • Billings, Montana, Forenede Stater, 59107
        • Billings Clinic Cancer Center
      • Billings, Montana, Forenede Stater, 59101
        • Montana Cancer Consortium NCORP
      • Bozeman, Montana, Forenede Stater, 59715
        • Bozeman Deaconess Hospital
      • Butte, Montana, Forenede Stater, 59701
        • Saint James Community Hospital and Cancer Treatment Center
      • Great Falls, Montana, Forenede Stater, 59405
        • Benefis Healthcare- Sletten Cancer Institute
      • Great Falls, Montana, Forenede Stater, 59405
        • Big Sky Oncology
      • Helena, Montana, Forenede Stater, 59601
        • Saint Peter's Community Hospital
      • Kalispell, Montana, Forenede Stater, 59901
        • Kalispell Regional Medical Center
      • Kalispell, Montana, Forenede Stater, 59901
        • Kalispell Medical Oncology
      • Missoula, Montana, Forenede Stater, 59802
        • Saint Patrick Hospital - Community Hospital
      • Missoula, Montana, Forenede Stater, 59802
        • Montana Cancer Specialists
    • Nebraska
      • Kearney, Nebraska, Forenede Stater, 68847
        • CHI Health Good Samaritan
      • Lincoln, Nebraska, Forenede Stater, 68510
        • Nebraska Cancer Research Center
      • Omaha, Nebraska, Forenede Stater, 68124
        • Alegent Health Bergan Mercy Medical Center
      • Omaha, Nebraska, Forenede Stater, 68122
        • Alegent Health Immanuel Medical Center
      • Omaha, Nebraska, Forenede Stater, 68130
        • Alegent Health Lakeside Hospital
      • Omaha, Nebraska, Forenede Stater, 68131
        • Creighton University Medical Center
      • Omaha, Nebraska, Forenede Stater, 68106
        • Missouri Valley Cancer Consortium
    • Nevada
      • Las Vegas, Nevada, Forenede Stater, 89102
        • University Medical Center of Southern Nevada
      • Las Vegas, Nevada, Forenede Stater, 89106
        • Nevada Cancer Research Foundation CCOP
    • New Jersey
      • Camden, New Jersey, Forenede Stater, 08103
        • Cooper Hospital University Medical Center
      • East Orange, New Jersey, Forenede Stater, 07018-1095
        • Veterans Adminstration New Jersey Health Care System
      • Egg Harbor Township, New Jersey, Forenede Stater, 08234
        • AtlantiCare Surgery Center
      • Englewood, New Jersey, Forenede Stater, 07631
        • Englewood Hospital and Medical Center
      • Newark, New Jersey, Forenede Stater, 07103
        • UMDNJ - New Jersey Medical School
    • New York
      • Bronx, New York, Forenede Stater, 10461
        • Albert Einstein College Of Medicine
      • Bronx, New York, Forenede Stater, 10467-2490
        • Montefiore Medical Center - Moses Campus
      • Brooklyn, New York, Forenede Stater, 11203
        • Kings County Hospital
      • Brooklyn, New York, Forenede Stater, 11203
        • State University of New York Downstate Medical Center
      • Cooperstown, New York, Forenede Stater, 13326
        • Mary Imogene Bassett Hospital
      • Glens Falls, New York, Forenede Stater, 12801
        • Glens Falls Hospital
      • Middletown, New York, Forenede Stater, 10940
        • Orange Regional Medical Center
      • Mineola, New York, Forenede Stater, 11501
        • Winthrop University Hospital
      • New York, New York, Forenede Stater, 10032
        • Columbia University Medical Center
      • Rochester, New York, Forenede Stater, 14642
        • University of Rochester
      • Staten Island, New York, Forenede Stater, 10305
        • Staten Island University Hospital
    • North Carolina
      • Asheboro, North Carolina, Forenede Stater, 27203
        • Randolph Hospital
      • Goldsboro, North Carolina, Forenede Stater, 27534
        • Wayne Memorial Hospital
      • Greensboro, North Carolina, Forenede Stater, 27403
        • Cone Health Cancer Center
      • Kinston, North Carolina, Forenede Stater, 28501
        • Kinston Medical Specialists PA
      • Pinehurst, North Carolina, Forenede Stater, 28374
        • FirstHealth of the Carolinas-Moore Regional Hosiptal
      • Reidsville, North Carolina, Forenede Stater, 27320
        • Annie Penn Memorial Hospital
      • Statesville, North Carolina, Forenede Stater, 28677
        • Iredell Memorial Hospital
      • Winston-Salem, North Carolina, Forenede Stater, 27104
        • Southeast Cancer Control Consortium CCOP
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Sanford Bismarck Medical Center
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Mid Dakota Clinic
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Saint Alexius Medical Center
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Clinic North-Fargo
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Medical Center-Fargo
      • Fargo, North Dakota, Forenede Stater, 58122
        • Roger Maris Cancer Center
    • Ohio
      • Akron, Ohio, Forenede Stater, 44304
        • Summa Akron City Hospital/Cooper Cancer Center
      • Akron, Ohio, Forenede Stater, 44307
        • Akron General Medical Center
      • Barberton, Ohio, Forenede Stater, 44203
        • Summa Barberton Hospital
      • Beachwood, Ohio, Forenede Stater, 44122
        • Cleveland Clinic Cancer Center Beachwood
      • Belpre, Ohio, Forenede Stater, 45714
        • Strecker Cancer Center-Belpre
      • Bowling Green, Ohio, Forenede Stater, 43402
        • Toledo Clinic Cancer Centers-Bowling Green
      • Chillicothe, Ohio, Forenede Stater, 45601
        • Adena Regional Medical Center
      • Cincinnati, Ohio, Forenede Stater, 45220
        • Good Samaritan Hospital - Cincinnati
      • Cincinnati, Ohio, Forenede Stater, 45242
        • Bethesda North Hospital
      • Cincinnati, Ohio, Forenede Stater, 45242
        • Oncology Hematology Care Inc-Blue Ash
      • Cincinnati, Ohio, Forenede Stater, 45202
        • Oncology Hematology Care Inc-Eden Park
      • Cincinnati, Ohio, Forenede Stater, 45211
        • Oncology Hematology Care Inc-Mercy West
      • Cincinnati, Ohio, Forenede Stater, 45230
        • Oncology Hematology Care Inc - Anderson
      • Cincinnati, Ohio, Forenede Stater, 45236
        • Oncology Hematology Care Inc - Kenwood
      • Cleveland, Ohio, Forenede Stater, 44106
        • Case Western Reserve University
      • Cleveland, Ohio, Forenede Stater, 44109
        • MetroHealth Medical Center
      • Cleveland, Ohio, Forenede Stater, 44195
        • Cleveland Clinic Foundation
      • Cleveland, Ohio, Forenede Stater, 44111
        • Cleveland Clinic Cancer Center/Fairview Hospital
      • Columbus, Ohio, Forenede Stater, 43214
        • Riverside Methodist Hospital
      • Columbus, Ohio, Forenede Stater, 43210
        • Ohio State University Comprehensive Cancer Center
      • Columbus, Ohio, Forenede Stater, 43219
        • The Mark H Zangmeister Center
      • Columbus, Ohio, Forenede Stater, 43214
        • Columbus Oncology and Hematology Associates Inc
      • Columbus, Ohio, Forenede Stater, 43228
        • Doctors Hospital
      • Columbus, Ohio, Forenede Stater, 43215
        • Grant Medical Center
      • Columbus, Ohio, Forenede Stater, 43222
        • Mount Carmel Health Center West
      • Columbus, Ohio, Forenede Stater, 43215
        • Columbus CCOP
      • Dayton, Ohio, Forenede Stater, 45406
        • Good Samaritan Hospital - Dayton
      • Dayton, Ohio, Forenede Stater, 45409
        • Miami Valley Hospital
      • Dayton, Ohio, Forenede Stater, 45415
        • Samaritan North Health Center
      • Dayton, Ohio, Forenede Stater, 45405
        • Grandview Hospital
      • Dayton, Ohio, Forenede Stater, 45420
        • Dayton CCOP
      • Delaware, Ohio, Forenede Stater, 43015
        • Delaware Health Center-Grady Cancer Center
      • Delaware, Ohio, Forenede Stater, 43015
        • Delaware Radiation Oncology
      • Delaware, Ohio, Forenede Stater, 43015
        • Grady Memorial Hospital
      • Elyria, Ohio, Forenede Stater, 44035
        • Mercy Cancer Center-Elyria
      • Elyria, Ohio, Forenede Stater, 44035
        • Hematology Oncology Center Incorporated
      • Fairfield, Ohio, Forenede Stater, 45014
        • Oncology Hematology Care Inc-Healthplex
      • Findlay, Ohio, Forenede Stater, 45840
        • Blanchard Valley Hospital
      • Franklin, Ohio, Forenede Stater, 45005-1066
        • Atrium Medical Center-Middletown Regional Hospital
      • Greenville, Ohio, Forenede Stater, 45331
        • Wayne Hospital
      • Kettering, Ohio, Forenede Stater, 45429
        • Kettering Medical Center
      • Lancaster, Ohio, Forenede Stater, 43130
        • Fairfield Medical Center
      • Lancaster, Ohio, Forenede Stater, 43130
        • Lancaster Radiation Oncology
      • Lima, Ohio, Forenede Stater, 45801
        • Saint Rita's Medical Center
      • Lima, Ohio, Forenede Stater, 45804
        • Lima Memorial Hospital
      • Marietta, Ohio, Forenede Stater, 45750
        • Marietta Memorial Hospital
      • Maumee, Ohio, Forenede Stater, 43537
        • Toledo Clinic Cancer Centers-Maumee
      • Maumee, Ohio, Forenede Stater, 43537
        • Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
      • Mayfield Heights, Ohio, Forenede Stater, 44124
        • Hillcrest Hospital Cancer Center
      • Mount Vernon, Ohio, Forenede Stater, 43050
        • Knox Community Hospital
      • Newark, Ohio, Forenede Stater, 43055
        • Licking Memorial Hospital
      • Newark, Ohio, Forenede Stater, 43055
        • Newark Radiation Oncology
      • Oregon, Ohio, Forenede Stater, 43616
        • Saint Charles Hospital
      • Oregon, Ohio, Forenede Stater, 43616
        • Toledo Clinic Cancer Centers-Oregon
      • Portsmouth, Ohio, Forenede Stater, 45662
        • Southern Ohio Medical Center
      • Sandusky, Ohio, Forenede Stater, 44870
        • North Coast Cancer Care
      • Springfield, Ohio, Forenede Stater, 45505
        • Springfield Regional Medical Center
      • Strongsville, Ohio, Forenede Stater, 44136
        • Cleveland Clinic Cancer Center Strongsville
      • Sylvania, Ohio, Forenede Stater, 43560
        • Flower Hospital
      • Tiffin, Ohio, Forenede Stater, 44883
        • Mercy Hospital of Tiffin
      • Toledo, Ohio, Forenede Stater, 43608
        • Saint Vincent Mercy Medical Center
      • Toledo, Ohio, Forenede Stater, 43623
        • Toledo Clinic Cancer Centers-Toledo
      • Toledo, Ohio, Forenede Stater, 43614
        • University of Toledo
      • Toledo, Ohio, Forenede Stater, 43617
        • Toledo Community Hospital Oncology Program CCOP
      • Toledo, Ohio, Forenede Stater, 43606
        • The Toledo Hospital/Toledo Children's Hospital
      • Toledo, Ohio, Forenede Stater, 43623
        • Mercy Saint Anne Hospital
      • Troy, Ohio, Forenede Stater, 45373
        • Upper Valley Medical Center
      • Wauseon, Ohio, Forenede Stater, 43567
        • Fulton County Health Center
      • Westerville, Ohio, Forenede Stater, 43081
        • Saint Ann's Hospital
      • Wooster, Ohio, Forenede Stater, 44691
        • Cleveland Clinic Wooster Specialty Center
      • Xenia, Ohio, Forenede Stater, 45385
        • Greene Memorial Hospital
      • Zanesville, Ohio, Forenede Stater, 43701
        • Genesis HealthCare System
    • Oklahoma
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • University of Oklahoma Health Sciences Center
      • Tulsa, Oklahoma, Forenede Stater, 74146
        • Tulsa Cancer Institute
      • Tulsa, Oklahoma, Forenede Stater, 74136
        • Natalie Warren Bryant Cancer Center at Saint Francis
      • Tulsa, Oklahoma, Forenede Stater, 74104
        • Oklahoma Oncology Inc
      • Tulsa, Oklahoma, Forenede Stater, 74136
        • Warren Cancer Research Foundation
    • Oregon
      • Gresham, Oregon, Forenede Stater, 97030
        • Legacy Mount Hood Medical Center
      • Portland, Oregon, Forenede Stater, 97210
        • Legacy Good Samaritan Hospital and Medical Center
      • Portland, Oregon, Forenede Stater, 97227
        • Legacy Emanuel Hospital and Health Center
      • Tualatin, Oregon, Forenede Stater, 97062
        • Legacy Meridian Park Hospital
    • Pennsylvania
      • Abington, Pennsylvania, Forenede Stater, 19001
        • Abington Memorial Hospital
      • Allentown, Pennsylvania, Forenede Stater, 18103
        • Lehigh Valley Hospital-Cedar Crest
      • Bethlehem, Pennsylvania, Forenede Stater, 18017
        • Lehigh Valley Hospital - Muhlenberg
      • Bryn Mawr, Pennsylvania, Forenede Stater, 19010
        • Bryn Mawr Hospital
      • Danville, Pennsylvania, Forenede Stater, 17822
        • Geisinger Medical Center
      • Hazleton, Pennsylvania, Forenede Stater, 18201
        • Geisinger Medical Center-Cancer Center Hazleton
      • Lancaster, Pennsylvania, Forenede Stater, 17604
        • Lancaster General Hospital
      • Lewisburg, Pennsylvania, Forenede Stater, 17837
        • Geisinger Medical Oncology-Lewisburg
      • Paoli, Pennsylvania, Forenede Stater, 19301
        • Paoli Memorial Hospital
      • Pittsburgh, Pennsylvania, Forenede Stater, 15232
        • University of Pittsburgh Cancer Institute (UPCI)
      • Pottsville, Pennsylvania, Forenede Stater, 17901
        • Geisinger Medical Oncology-Pottsville
      • Sayre, Pennsylvania, Forenede Stater, 18840
        • Guthrie Medical Group PC-Robert Packer Hospital
      • State College, Pennsylvania, Forenede Stater, 16801
        • Geisinger Medical Group
      • West Reading, Pennsylvania, Forenede Stater, 19611
        • Reading Hospital
      • Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
        • Geisinger Wyoming Valley/Henry Cancer Center
      • Wynnewood, Pennsylvania, Forenede Stater, 19096
        • Lankenau Medical Center
      • Wynnewood, Pennsylvania, Forenede Stater, 19096
        • Mainline Health CCOP
    • South Dakota
      • Sioux Falls, South Dakota, Forenede Stater, 57105
        • Avera Cancer Institute
      • Sioux Falls, South Dakota, Forenede Stater, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
      • Sioux Falls, South Dakota, Forenede Stater, 57104
        • Sanford Cancer Center-Oncology Clinic
    • Tennessee
      • Chattanooga, Tennessee, Forenede Stater, 37403
        • Erlanger Medical Center
      • Nashville, Tennessee, Forenede Stater, 37232
        • Vanderbilt University/Ingram Cancer Center
    • Texas
      • Amarillo, Texas, Forenede Stater, 79106
        • The Don and Sybil Harrington Cancer Center
      • Lubbock, Texas, Forenede Stater, 79430
        • Texas Tech University Health Sciences Center
    • Utah
      • Salt Lake City, Utah, Forenede Stater, 84112
        • Huntsman Cancer Institute/University of Utah
    • Virginia
      • Danville, Virginia, Forenede Stater, 24541
        • Danville Regional Medical Center
      • Danville, Virginia, Forenede Stater, 24541
        • Danville Hematology Oncology
      • Fredericksburg, Virginia, Forenede Stater, 22401
        • Fredericksburg Oncology Inc
      • Richmond, Virginia, Forenede Stater, 23298
        • Virginia Commonwealth University/Massey Cancer Center
    • Washington
      • Anacortes, Washington, Forenede Stater, 98221
        • Cancer Care Center at Island Hospital
      • Bellingham, Washington, Forenede Stater, 98225
        • PeaceHealth Saint Joseph Medical Center
      • Bremerton, Washington, Forenede Stater, 98310
        • Harrison HealthPartners Hematology and Oncology-Bremerton
      • Burien, Washington, Forenede Stater, 98166
        • Highline Medical Center-Main Campus
      • Edmonds, Washington, Forenede Stater, 98026
        • Swedish Medical Center-Edmonds
      • Issaquah, Washington, Forenede Stater, 98029
        • Swedish Cancer Institute-Issaquah
      • Kennewick, Washington, Forenede Stater, 99336
        • Kadlec Clinic Hematology and Oncology
      • Kirkland, Washington, Forenede Stater, 98034
        • Seattle Cancer Care Alliance at EvergreenHealth
      • Mount Vernon, Washington, Forenede Stater, 98274
        • Skagit Valley Hospital
      • Poulsbo, Washington, Forenede Stater, 98370
        • Harrison HealthPartners Hematology and Oncology-Poulsbo
      • Seattle, Washington, Forenede Stater, 98109
        • Fred Hutchinson Cancer Research Center
      • Seattle, Washington, Forenede Stater, 98195
        • University of Washington Medical Center
      • Seattle, Washington, Forenede Stater, 98104
        • Harborview Medical Center
      • Seattle, Washington, Forenede Stater, 98107
        • Swedish Medical Center-Ballard Campus
      • Seattle, Washington, Forenede Stater, 98104
        • Minor and James Medical PLLC
      • Seattle, Washington, Forenede Stater, 98112
        • Group Health Cooperative-Seattle
      • Seattle, Washington, Forenede Stater, 98122-4307
        • Swedish Medical Center-First Hill
      • Seattle, Washington, Forenede Stater, 98112
        • Group Health Cooperative of Puget Sound Oncology Consortium
      • Sedro-Woolley, Washington, Forenede Stater, 98284
        • United General Hospital
      • Spokane, Washington, Forenede Stater, 99218
        • Evergreen Hematology and Oncology PS
      • Spokane, Washington, Forenede Stater, 99202
        • Cancer Care Northwest - Spokane South
      • Spokane, Washington, Forenede Stater, 99220
        • Rockwood Clinic
      • Vancouver, Washington, Forenede Stater, 98686
        • Legacy Salmon Creek Hospital
      • Wenatchee, Washington, Forenede Stater, 98801
        • Wenatchee Valley Hospital and Clinics
    • West Virginia
      • Charleston, West Virginia, Forenede Stater, 25304
        • West Virginia University Charleston
      • Morgantown, West Virginia, Forenede Stater, 26506
        • West Virginia University Healthcare
    • Wisconsin
      • Antigo, Wisconsin, Forenede Stater, 54409
        • Langlade Hospital and Cancer Center
      • Chippewa Falls, Wisconsin, Forenede Stater, 54729
        • Marshfield Clinic-Chippewa Center
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Marshfield Clinic Cancer Center at Sacred Heart
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Sacred Heart Hospital
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Gundersen Lutheran Medical Center
      • Ladysmith, Wisconsin, Forenede Stater, 54848
        • Marshfield Clinic - Ladysmith Center
      • Madison, Wisconsin, Forenede Stater, 53717
        • Dean Hematology and Oncology Clinic
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Marshfield Clinic
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Saint Joseph's Hospital
      • Minocqua, Wisconsin, Forenede Stater, 54548
        • Marshfield Clinic-Minocqua Center
      • Mukwonago, Wisconsin, Forenede Stater, 53149
        • D N Greenwald Center
      • New Richmond, Wisconsin, Forenede Stater, 54017
        • Cancer Center of Western Wisconsin
      • Oconomowoc, Wisconsin, Forenede Stater, 53066
        • Oconomowoc Memorial Hospital-ProHealth Care Inc
      • Rhinelander, Wisconsin, Forenede Stater, 54501
        • Saint Mary's Hospital
      • Rhinelander, Wisconsin, Forenede Stater, 54501
        • Marshfield Clinic at James Beck Cancer Center
      • Rice Lake, Wisconsin, Forenede Stater, 54868
        • Marshfield Clinic-Rice Lake Center
      • Stevens Point, Wisconsin, Forenede Stater, 54481
        • Saint Michael's Hospital
      • Stevens Point, Wisconsin, Forenede Stater, 54481
        • Marshfield Clinic Cancer Care at Saint Michael's Hospital
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • Waukesha Memorial Hospital
      • Wausau, Wisconsin, Forenede Stater, 54401
        • Aspirus Regional Cancer Center
      • Wausau, Wisconsin, Forenede Stater, 54401
        • Marshfield Clinic-Wausau Center
      • Weston, Wisconsin, Forenede Stater, 54476
        • Diagnostic and Treatment Center
      • Weston, Wisconsin, Forenede Stater, 54476
        • Marshfield Clinic - Weston Center
      • Weston, Wisconsin, Forenede Stater, 54476
        • Saint Clare's Hospital
      • Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
        • Marshfield Clinic - Wisconsin Rapids Center
    • Wyoming
      • Casper, Wyoming, Forenede Stater, 82609
        • Rocky Mountain Oncology
      • Sheridan, Wyoming, Forenede Stater, 82801
        • Welch Cancer Center

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inklusionskriterier:

  • Patienter skal have histologisk eller cytologisk bekræftet diagnose af pancreas adenocarcinom; patienter med endokrine eller neuroendokrine tumorer, lymfom i bugspytkirtlen eller ampulær cancer er ikke kvalificerede
  • Patienter skal have fjernmetastatisk sygdom; patienter med makroskopisk resterende sygdom efter resektion som det eneste sygdomssted er ikke kvalificerede; patienten må ikke have klinisk signifikant ascites (defineret som krævende paracentese) eller have hjernemetastaser

  • Patienter skal have modtaget én linje, og ikke mere end én linje, af tidligere gemcitabin-baseret kemoterapi for fremskreden/metastatisk bugspytkirtelkræft og skal have dokumentation for metastatisk sygdomsprogression under denne behandling; dokumenteret sygdomsprogression skal ske inden for 42 dage efter sidste behandling; ELLER

    • For patienter, der modtog én linje gemcitabin-baseret kemoterapi til behandling i adjuverende omgivelser, skal tilbagefald til et metastatisk sted dokumenteres ved billeddiagnostiske undersøgelser inden for 6 måneder efter afslutning af kemoterapi; kemoradiation som en del af adjuverende behandling er acceptabel; hvis patienten modtog én linje med adjuverende gemcitabin-baseret behandling og havde sygdomsrecidiv efter 6 måneders afsluttet kemoterapi, vil patienterne kun være berettigede efter at have svigtet en ekstra linje gemcitabin-baseret kemoterapi, der bruges til at behandle den metastatiske sygdom
  • Patienter skal have målbar og/eller ikke-målbar sygdom; røntgenbilleder, scanninger. eller fysiske undersøgelser til vurdering af målbar sygdom skal være afsluttet inden for 28 dage før registrering; røntgenbilleder, scanninger eller andre tests til vurdering af ikke-målbar sygdom skal være gennemført inden for 42 dage før registrering; al sygdom skal vurderes og dokumenteres på Baseline Tumor Assessment Form
  • Patienter skal have afsluttet systemisk behandling mindst 14 dage før registrering, enhver kirurgisk procedure skal være udført mindst 14 dage før registrering, og strålebehandling skal være afsluttet mindst 7 dage før registrering; patienterne skal være kommet sig til =< grad 1 fra nogen af ​​virkningerne af tidligere behandlinger eller procedurer
  • Patienter må ikke planlægge at modtage samtidig kemoterapi, strålebehandling, midler, der vides at forlænge korrigeret QT (QTc)-interval, eller midler, der vides at være stærke inducere eller hæmmere af cytokrom P450 3A4/5 (CYP3A4/5) eller cytokrom P450 1A2 (CYP1A2)
  • Patienten må ikke have modtaget tidligere behandling med fluorouracil, irinotecan, leucovorin calcium og oxaliplatin (FOLFIRINOX), FOLFOX, oxaliplatin-baseret kemoterapi, mitogen-aktiveret proteinkinase (MEK) hæmmere, phosphoinositid-3-kinase (PI3K) hæmmere, kinase B (AKT) hæmmere
  • Zubrod præstationsstatus på 0-1
  • Leukocytter >= 3.000/mcL
  • Absolut neutrofiltal (ANC) >= 1.500/mcL
  • Blodplader >= 100.000/mcL
  • Hæmoglobin >= 9,0 g/dL

  • Patienter skal have tilstrækkelig nyrefunktion som dokumenteret af mindst EN af følgende:

    • Serumkreatinin =< 1,5 mg/dL inden for 14 dage før registrering
    • Beregnet kreatininclearance >= 60 ml/min; den serumkreatininværdi, der er anvendt i beregningen, skal være opnået inden for 14 dage før registrering
  • Total bilirubin =< 1,5 gange institutionel øvre normalgrænse (IULN)
  • Aspartataminotransferase (AST) og alaninaminotransferase (ALT) begge =< 2,5 gange IULN
  • Patienter skal have et albuminniveau >= 3,0 g/dL inden for 14 dage før registrering
  • Patienter skal have en International Normalized Ratio (INR) =< 1,5 gange IULN inden for 14 dage før registrering
  • Patienter skal have et elektrokardiogram (EKG) inden for 14 dage før registrering; patienter skal have QTcF (efter Fridericias beregning) =< 450 msek (mand) eller =< 470 msek (kvinde)
  • Patienter med baseline neuropati skal være =< grad 1 i henhold til Common Terminology Criteria for Adverse Events (CTCAE) v 4.0
  • Patienter må ikke have ukontrolleret diarré eller aktiv infektion, der kræver antibiotika og være fuldt restitueret fra tidligere alvorlige infektioner inden for 7 dage før registrering
  • Patienter skal kunne sluge tabletter og kapsler
  • Patienter med diabetes skal være godt kontrolleret med fastende glukose =< grad 1 i henhold til CTCAE v 4.0 inden for 14 dage før registrering
  • Patienter med kongestiv hjerteinsufficiens i anamnesen skal have en ejektionsfraktion >= 55 % inden for 14 dage før registrering
  • Patienter må ikke have nogen af ​​følgende: ukontrolleret hypertension, akut koronarsyndrom inden for 6 måneder før registrering, dårligt kontrolleret angina, New York Heart Association klasse II-IV hjertesvigt, tidligere eller nuværende kardiomyopati, atrieflimren eller alvorlig hjerteklapsygdom
  • Patienter må ikke have en nuværende eller tidligere historie med central serøs retinopati, retinal veneokklusion, nethindeløsning eller have ukontrolleret glaukom (uanset intraokulært tryk [IOP])
  • Ingen tidligere malignitet er tilladt med undtagelse af følgende: tilstrækkeligt behandlet basalcelle- eller pladecellehudkræft, in situ livmoderhalskræft, tilstrækkeligt behandlet stadium I eller II kræft, som patienten i øjeblikket er i fuldstændig remission fra, eller enhver anden kræftsygdom, som patienten har udsat for. har været sygdomsfri i fem år
  • Patienter må ikke være gravide eller ammende; kvinder/mænd med reproduktionspotentiale skal have accepteret at bruge en effektiv præventionsmetode under undersøgelsen plus mindst 16 uger efter sidste dosis; en kvinde anses for at have "reproduktionspotentiale", hvis hun har haft menstruation på noget tidspunkt i de foregående 12 på hinanden følgende måneder; ud over rutinepræventionsmetoder omfatter "effektiv prævention" også heteroseksuel cølibat og kirurgi beregnet til at forhindre graviditet (eller med en bivirkning af graviditetsforebyggelse) defineret som en hysterektomi, bilateral oophorektomi eller bilateral tubal ligering; men hvis en tidligere cølibatpatient på noget tidspunkt vælger at blive heteroseksuelt aktiv i løbet af tidsperioden for brug af præventionsforanstaltninger, der er beskrevet i protokollen, er han/hun ansvarlig for at påbegynde præventionsforanstaltninger
  • Forstudiehistorie og fysisk skal indhentes inden for 28 dage før registrering
  • Sites skal søge yderligere patientsamtykke til fremtidig brug af prøver
  • Alle patienter skal informeres om undersøgelsens karakter af denne undersøgelse og skal underskrive og give skriftligt informeret samtykke i overensstemmelse med institutionelle og føderale retningslinjer
  • Som en del af registreringsprocessen for Oncology Patient Enrollment Network (OPEN) oplyses den behandlende institutions identitet for at sikre, at den aktuelle (inden for 365 dage) dato for institutionsbedømmelsesudvalgets godkendelse af denne undersøgelse er blevet indtastet i systemet

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: Arm I (mFOLFOX-kur)
Patienterne får oxaliplatin IV over 2 timer på dag 1 og 15 og fluorouracil IV over 46-48 timer på dag 1-2 og 15-16.
Medicin: Fluorouracil
Givet IV
Andre navne:
  • 5-FU
  • 5-Fluracil
  • Fluracil
  • 5-fluor-2,4(1H,3H)-pyrimidindion
  • 5-Fluorouracil
  • AccuSite
  • Fluor Uracil
  • Fluouracil
  • Flurablastin
  • Fluracedyl
  • Fluril
  • Fluroblastin
  • Ribofluor
  • Ro 2-9757
  • Ro-2-9757
  • Adrucil
  • Efudex
  • Actino-Hermal
  • Arumel
  • Cytosafe
  • Efurix
  • Fiverocil
  • Fluoroplex
  • Flurox
  • Timazin
Medicin: Oxaliplatin
Givet IV
Andre navne:
  • 1-OHP
  • Dakotin
  • Dacplat
  • Eloxatin
  • Diaminocyclohexan Oxalatoplatin
  • JM-83
  • Oxalatoplatin
  • RP 54780
  • RP-54780
  • SR-96669
Eksperimentel: Arm II (Akt-hæmmer MK2206 og selumetinib)
Patienterne får Akt-hæmmer MK2206 PO på dag 1, 8, 15 og 22, og selumetinib PO dagligt på dag 1-28.
Medicin: Akt Inhibitor MK2206
Givet PO
Andre navne:
  • MK2206
Medicin: Selumetinib
Givet PO
Andre navne:
  • AZD6244
  • ARRY-142886
  • MEK-hæmmer AZD6244

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Samlet overlevelse
Tidsramme: Op til 3 år
Fra registreringsdatoen til datoen for dødsfald på grund af enhver årsag. Patienter, der sidst vides at være i live, censureres på datoen for sidste kontakt.
Op til 3 år

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Antal patienter med grad 3 til grad 5 bivirkninger, der er relateret til undersøgelsesmedicin
Tidsramme: Op til 3 år
Kun uønskede hændelser, der muligvis, sandsynligvis eller helt sikkert er relateret til undersøgelseslægemidlet, er rapporteret.
Op til 3 år

Andre resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Progressionsfri overlevelse
Tidsramme: Op til 3 år
Fra registreringsdatoen til datoen for første dokumentation for progression eller symptomatisk forværring eller død på grund af en hvilken som helst årsag. Patienter, der sidst er kendt for at være i live og progressionsfri, censureres på datoen for sidste kontakt.
Op til 3 år
Objektiv svarprocent
Tidsramme: Op til 3 år
Bekræftet respons (CR) er to eller flere objektive statusser af CR med mindst fire ugers mellemrum dokumenteret før progression eller symptomatisk forværring. Delvis respons (PR) er to eller flere objektive statusser af PR eller bedre med minimum fire ugers mellemrum dokumenteret før progression eller symptomatisk forværring. Ubekræftet CR er en objektiv status for CR dokumenteret før progression eller symptomatisk forværring, men som ikke kvalificeres som CR eller PR. Ubekræftet PR er en objektiv status for PR dokumenteret før progression eller symptomatisk forværring, men ikke kvalificeret som CR, PR eller ubekræftet CR.
Op til 3 år

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

National Cancer Institute (NCI)

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. august 2012

Primær færdiggørelse (Faktiske)

1. juni 2015

Studieafslutning (Faktiske)

1. juni 2015

Datoer for studieregistrering

Først indsendt

3. august 2012

Først indsendt, der opfyldte QC-kriterier

3. august 2012

Først opslået (Skøn)

7. august 2012

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Skøn)

9. marts 2016

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

10. februar 2016

Sidst verificeret

1. juli 2015

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • NCI-2012-01993 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
  • U10CA032102 (U.S. NIH-bevilling/kontrakt)
  • U10CA180888 (U.S. NIH-bevilling/kontrakt)
  • SWOG-S1115
  • CDR0000737878
  • S1115 (Anden identifikator: CTEP)

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Duktalt adenokarcinom i bugspytkirtlen

Kliniske forsøg med Akt Inhibitor MK2206

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Placeringer

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