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Enzalutamid med eller uden abirateron og prednison til behandling af patienter med kastrationsresistent metastatisk prostatakræft

13. september 2023 opdateret af: Alliance for Clinical Trials in Oncology

Fase III-forsøg med Enzalutamid (NSC# 766085) versus Enzalutamid, Abiraterone og Prednison til kastrationsresistent metastatisk prostatakræft

Dette randomiserede fase III-studie undersøger enzalutamid for at se, hvor godt det virker sammenlignet med enzalutamid, abirateron og prednison til behandling af patienter med kastrationsresistent metastatisk prostatacancer. Androgener kan forårsage vækst af prostatacancerceller. Lægemidler, såsom enzalutamid, abirateronacetat og prednison, kan mindske mængden af androgener lavet af kroppen.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Patienterne er randomiseret til en af to behandlingsgrupper: enzalutamid eller enzalutamid, abirateron og prednison. Behandlingen vil fortsætte indtil sygdomsprogression eller uacceptabel toksicitet. Patienterne følges for kliniske resultater i maksimalt 5 år efter undersøgelsesbehandling. De primære og sekundære mål er beskrevet nedenfor.

Primært mål:
At sammenligne den samlede overlevelse af patienter med progressiv metastatisk kastrationsresistent prostatacancer (CRPC) behandlet med enten enzalutamid alene eller enzalutamid med abirateron og prednison
Sekundære mål:
- At vurdere toksicitetsprofilen grad 3 eller højere og sammenligne sikkerhed efter behandlingsarm.
- For at vurdere og sammenligne fald i prostataspecifikt antigen (PSA) efter behandling efter behandlingsarm.
- At sammenligne radiografisk progressionsfri overlevelse defineret af Prostate Cancer Working Group 2 (PCWG2) og objektiv responsrate efter behandlingsarm.
- For at teste for radiografisk progressionsfri overlevelse (rPFS) behandlingsinteraktion til at forudsige den samlede overlevelse.
- At vurdere før- og efterbehandlingsmålinger af tumorbelastning og knogleaktivitet ved hjælp af natriumfluorid (NaF) positronemissionstomografi (PET)/computertomografi (CT) og technetium (Tc) methylendiphosphonat (MDP) knoglescintigrafi og korrelere disse mål med samlet overlevelse.
- At udvikle og validere prognostiske og prædiktive modeller for samlet overlevelse, der inkluderer baseline kliniske og molekylære markører.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

1311

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Canada
- Alberta
  - Edmonton, Alberta, Canada, T6G 1Z2
    - Cross Cancer Institute
- British Columbia
  - Vancouver, British Columbia, Canada, V5Z 4E6
    - BCCA-Vancouver Cancer Centre
- New Brunswick
  - Moncton, New Brunswick, Canada, E1C 6Z8
    - The Moncton Hospital
  - Moncton, New Brunswick, Canada, E1C 8X3
    - The Vitalite Health Network - Dr Leon Richard Oncology Centre
  - Saint John, New Brunswick, Canada, E2L 4L2
    - Atlantic Health Sciences Corporation-Saint John Regional Hospital
- Newfoundland and Labrador
  - St. John's, Newfoundland and Labrador, Canada, A1B 3V6
    - Doctor H. Bliss Murphy Cancer Centre
- Ontario
  - Cambridge, Ontario, Canada, N1R 3G2
    - Cambridge Memorial Hospital
  - Kitchener, Ontario, Canada, N2G 1G3
    - Grand River Regional Cancer Centre at Grand River Hospital
- Saskatchewan
  - Regina, Saskatchewan, Canada, S4T 7T1
    - Allan Blair Cancer Centre
Forenede Stater
- Alabama
  - Birmingham, Alabama, Forenede Stater, 35233
    - University of Alabama at Birmingham Cancer Center
  - Mobile, Alabama, Forenede Stater, 36608
    - Southern Cancer Center PC-Providence
- Alaska
  - Anchorage, Alaska, Forenede Stater, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, Forenede Stater, 99508
    - Providence Alaska Medical Center
- Arizona
  - Scottsdale, Arizona, Forenede Stater, 85259
    - Mayo Clinic in Arizona
  - Tucson, Arizona, Forenede Stater, 85704
    - University of Arizona Cancer Center-Orange Grove Campus
  - Tucson, Arizona, Forenede Stater, 85719
    - University of Arizona Cancer Center-North Campus
  - Tucson, Arizona, Forenede Stater, 85724
    - The University of Arizona Medical Center-University Campus
- Arkansas
  - Jonesboro, Arkansas, Forenede Stater, 72401
    - Fowler Family Center for Cancer Care
  - Little Rock, Arkansas, Forenede Stater, 72205
    - University of Arkansas for Medical Sciences
  - Little Rock, Arkansas, Forenede Stater, 72205
    - Veteran's Administration Medical Center
- California
  - Anaheim, California, Forenede Stater, 92807
    - Kaiser Permanente-Anaheim
  - Antioch, California, Forenede Stater, 94531
    - Kaiser Permanente-Deer Valley Medical Center
  - Baldwin Park, California, Forenede Stater, 91706
    - Kaiser Permanente-Baldwin Park
  - Bellflower, California, Forenede Stater, 90706
    - Kaiser Permanente-Bellflower
  - Berkeley, California, Forenede Stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burbank, California, Forenede Stater, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Duarte, California, Forenede Stater, 91010
    - City of Hope Comprehensive Cancer Center
  - Fontana, California, Forenede Stater, 92335
    - Kaiser Permanente Hospital
  - Fremont, California, Forenede Stater, 94538
    - Kaiser Permanente-Fremont
  - Fresno, California, Forenede Stater, 93720
    - Kaiser Permanente
  - Fresno, California, Forenede Stater, 93701
    - University Oncology Associates
  - Fresno, California, Forenede Stater, 93720
    - California Cancer Center - North Fresno
  - Greenbrae, California, Forenede Stater, 94904
    - Marin Cancer Care Inc
  - Harbor City, California, Forenede Stater, 90710
    - Kaiser Permanente - Harbor City
  - Irvine, California, Forenede Stater, 92618
    - Kaiser Permanente-Irvine
  - La Jolla, California, Forenede Stater, 92093
    - UC San Diego Moores Cancer Center
  - Loma Linda, California, Forenede Stater, 92354
    - Loma Linda University Medical Center
  - Los Angeles, California, Forenede Stater, 90033
    - USC / Norris Comprehensive Cancer Center
  - Los Angeles, California, Forenede Stater, 90033
    - Los Angeles County-USC Medical Center
  - Los Angeles, California, Forenede Stater, 90027
    - Kaiser Permanente Los Angeles Medical Center
  - Los Angeles, California, Forenede Stater, 90034
    - Kaiser Permanente-Cadillac
  - Marysville, California, Forenede Stater, 95901
    - Fremont - Rideout Cancer Center
  - Modesto, California, Forenede Stater, 95355
    - Memorial Medical Center
  - Modesto, California, Forenede Stater, 95356
    - Kaiser Permanente-Modesto
  - Newport Beach, California, Forenede Stater, 92663
    - USC Norris Oncology/Hematology-Newport Beach
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente-Oakland
  - Orange, California, Forenede Stater, 92868
    - UC Irvine Health/Chao Family Comprehensive Cancer Center
  - Palo Alto, California, Forenede Stater, 94301
    - Palo Alto Medical Foundation Health Care
  - Panorama City, California, Forenede Stater, 91402
    - Kaiser Permanente - Panorama City
  - Paradise, California, Forenede Stater, 95969
    - Feather River Cancer Center
  - Redwood City, California, Forenede Stater, 94063
    - Kaiser Permanente-Redwood City
  - Richmond, California, Forenede Stater, 94801
    - Kaiser Permanente-Richmond
  - Riverside, California, Forenede Stater, 92505
    - Kaiser Permanente-Riverside
  - Roseville, California, Forenede Stater, 95661
    - Kaiser Permanente-Roseville
  - Sacramento, California, Forenede Stater, 95817
    - University of California Davis Comprehensive Cancer Center
  - Sacramento, California, Forenede Stater, 95823
    - Kaiser Permanente-South Sacramento
  - Sacramento, California, Forenede Stater, 95825
    - Kaiser Permanente - Sacramento
  - Saint Helena, California, Forenede Stater, 94574
    - Saint Helena Hospital
  - San Diego, California, Forenede Stater, 92120
    - Kaiser Permanente-San Diego Zion
  - San Diego, California, Forenede Stater, 92134
    - Naval Medical Center -San Diego
  - San Diego, California, Forenede Stater, 92123
    - Sharp Memorial Hospital
  - San Diego, California, Forenede Stater, 92161
    - Veterans Administration-San Diego Medical Center
  - San Francisco, California, Forenede Stater, 94121
    - Veterans Affairs Medical Center - San Francisco
  - San Francisco, California, Forenede Stater, 94115
    - Kaiser Permanente-San Francisco
  - San Francisco, California, Forenede Stater, 94158
    - UCSF Medical Center-Mission Bay
  - San Francisco, California, Forenede Stater, 94115
    - UCSF Medical Center-Mount Zion
  - San Jose, California, Forenede Stater, 95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Leandro, California, Forenede Stater, 94577
    - Kaiser Permanente San Leandro
  - San Marcos, California, Forenede Stater, 92069
    - Kaiser Permanente-San Marcos
  - San Rafael, California, Forenede Stater, 94903
    - Kaiser Permanente-San Rafael
  - Santa Clara, California, Forenede Stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Cruz, California, Forenede Stater, 95065
    - Palo Alto Medical Foundation-Santa Cruz
  - Santa Rosa, California, Forenede Stater, 95403
    - Kaiser Permanente-Santa Rosa
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente-South San Francisco
  - Stockton, California, Forenede Stater, 95210
    - Kaiser Permanente-Stockton
  - Stockton, California, Forenede Stater, 95204
    - Saint Joseph's Medical Center
  - Sunnyvale, California, Forenede Stater, 94086
    - Palo Alto Medical Foundation-Sunnyvale
  - Vacaville, California, Forenede Stater, 95688
    - Kaiser Permanente Medical Center-Vacaville
  - Vallejo, California, Forenede Stater, 94589
    - Kaiser Permanente-Vallejo
  - Walnut Creek, California, Forenede Stater, 94596
    - Kaiser Permanente-Walnut Creek
  - Woodland Hills, California, Forenede Stater, 91367
    - Kaiser Permanente
- Colorado
  - Boulder, Colorado, Forenede Stater, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Colorado Springs, Colorado, Forenede Stater, 80909
    - Memorial Hospital Colorado Springs
  - Denver, Colorado, Forenede Stater, 80205
    - Kaiser Permanente-Franklin
  - Durango, Colorado, Forenede Stater, 81301
    - Southwest Oncology PC
  - Edwards, Colorado, Forenede Stater, 81632
    - The Shaw Regional Cancer Center
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Lakewood, Colorado, Forenede Stater, 80228
    - Rocky Mountain Cancer Centers-Lakewood
- Connecticut
  - Greenwich, Connecticut, Forenede Stater, 06830
    - Greenwich Hospital
  - Hartford, Connecticut, Forenede Stater, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Middletown, Connecticut, Forenede Stater, 06457
    - Middlesex Hospital
  - Norwalk, Connecticut, Forenede Stater, 06856
    - Norwalk Hospital
  - Norwich, Connecticut, Forenede Stater, 06360
    - Eastern Connecticut Hematology and Oncology Associates
  - Stamford, Connecticut, Forenede Stater, 06904
    - Stamford Hospital/Bennett Cancer Center
  - West Haven, Connecticut, Forenede Stater, 06516
    - Veterans Affairs Connecticut Healthcare System-West Haven Campus
- Delaware
  - Newark, Delaware, Forenede Stater, 19713
    - Medical Oncology Hematology Consultants PA
- District of Columbia
  - Washington, District of Columbia, Forenede Stater, 20007
    - MedStar Georgetown University Hospital
  - Washington, District of Columbia, Forenede Stater, 20016
    - Sibley Memorial Hospital
  - Washington, District of Columbia, Forenede Stater, 20422
    - Veterans Affairs Medical Center -Washington DC
- Florida
  - Jacksonville, Florida, Forenede Stater, 32207
    - Baptist MD Anderson Cancer Center
  - Lakeland, Florida, Forenede Stater, 33805
    - Lakeland Regional Cancer Center
  - Miami Beach, Florida, Forenede Stater, 33140
    - Mount Sinai Medical Center
  - Orlando, Florida, Forenede Stater, 32803
    - Florida Hospital Orlando
  - Orlando, Florida, Forenede Stater, 32806
    - UF Cancer Center at Orlando Health
  - Pensacola, Florida, Forenede Stater, 32504
    - Sacred Heart Hospital
- Georgia
  - Atlanta, Georgia, Forenede Stater, 30342
    - Northside Hospital
  - Columbus, Georgia, Forenede Stater, 31904
    - John B Amos Cancer Center
  - Decatur, Georgia, Forenede Stater, 30033
    - Atlanta VA Medical Center
  - Macon, Georgia, Forenede Stater, 31201
    - Medical Center of Central Georgia
  - Savannah, Georgia, Forenede Stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Valdosta, Georgia, Forenede Stater, 31602
    - South Georgia Medical Center/Pearlman Cancer Center
- Hawaii
  - 'Aiea, Hawaii, Forenede Stater, 96701
    - Pali Momi Medical Center
  - 'Aiea, Hawaii, Forenede Stater, 96701
    - Hawaii Oncology Inc-Pali Momi
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forenede Stater, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Hawaii Cancer Care Inc-Liliha
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Kuakini Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Island Urology
  - Honolulu, Hawaii, Forenede Stater, 96819
    - Kaiser Permanente Moanalua Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Hawaii Cancer Care Inc-POB II
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Hawaii Oncology Inc-POB I
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Hawaii Oncology Inc-Kuakini
  - Honolulu, Hawaii, Forenede Stater, 96859
    - Tripler Army Medical Center
  - Lihue, Hawaii, Forenede Stater, 96766
    - Wilcox Memorial Hospital and Kauai Medical Clinic
- Idaho
  - Boise, Idaho, Forenede Stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Post Falls, Idaho, Forenede Stater, 83854
    - Kootenai Cancer Center
- Illinois
  - Aurora, Illinois, Forenede Stater, 60504
    - Rush - Copley Medical Center
  - Bloomington, Illinois, Forenede Stater, 61704
    - Illinois CancerCare-Bloomington
  - Chicago, Illinois, Forenede Stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forenede Stater, 60612
    - Rush University Medical Center
  - Chicago, Illinois, Forenede Stater, 60608
    - Mount Sinai Hospital Medical Center
  - Chicago, Illinois, Forenede Stater, 60640
    - Weiss Memorial Hospital
  - Chicago, Illinois, Forenede Stater, 60657
    - Advocate Illinois Masonic Medical Center
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forenede Stater, 62526
    - Cancer Care Center of Decatur
  - Effingham, Illinois, Forenede Stater, 62401
    - Crossroads Cancer Center
  - Evanston, Illinois, Forenede Stater, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare-Galesburg
  - Geneva, Illinois, Forenede Stater, 60134
    - Northwestern Medicine Cancer Center Delnor
  - Glenview, Illinois, Forenede Stater, 60026
    - NorthShore University HealthSystem-Glenbrook Hospital
  - Harvey, Illinois, Forenede Stater, 60426
    - Ingalls Memorial Hospital
  - Highland Park, Illinois, Forenede Stater, 60035
    - NorthShore University HealthSystem-Highland Park Hospital
  - Hines, Illinois, Forenede Stater, 60141
    - Hines Veterans Administration Hospital
  - Maywood, Illinois, Forenede Stater, 60153
    - Loyola University Medical Center
  - Peoria, Illinois, Forenede Stater, 61615
    - Illinois CancerCare-Peoria
  - Quincy, Illinois, Forenede Stater, 62301
    - Quincy Medical Group-Clinic
  - River Forest, Illinois, Forenede Stater, 60305
    - West Suburban Medical Center
  - Rockford, Illinois, Forenede Stater, 61108
    - OSF Saint Anthony Medical Center
  - Springfield, Illinois, Forenede Stater, 62781
    - Memorial Medical Center
  - Springfield, Illinois, Forenede Stater, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Forenede Stater, 62702
    - Central Illinois Hematology Oncology Center
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center
  - Warrenville, Illinois, Forenede Stater, 60555
    - Northwestern Medicine Cancer Center Warrenville
- Indiana
  - Fort Wayne, Indiana, Forenede Stater, 46845
    - Fort Wayne Medical Oncology and Hematology Inc-Parkview
  - Fort Wayne, Indiana, Forenede Stater, 46804
    - Fort Wayne Medical Oncology and Hematology Inc - Jefferson Boulevard
  - Mishawaka, Indiana, Forenede Stater, 46545
    - Michiana Hematology Oncology PC-Mishawaka
  - Munster, Indiana, Forenede Stater, 46321
    - The Community Hospital
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - Westville, Indiana, Forenede Stater, 46391
    - Michiana Hematology Oncology PC-Westville
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic PC-William R Bliss Cancer Center
  - Bettendorf, Iowa, Forenede Stater, 52722
    - Hematology Oncology Associates-Quad Cities
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Oncology Associates at Mercy Medical Center
  - Clive, Iowa, Forenede Stater, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, Forenede Stater, 50325
    - Medical Oncology and Hematology Associates-West Des Moines
  - Davenport, Iowa, Forenede Stater, 52803
    - Genesis Medical Center - East Campus
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50314
    - Medical Oncology and Hematology Associates-Laurel
  - Iowa City, Iowa, Forenede Stater, 52242
    - University of Iowa/Holden Comprehensive Cancer Center
  - Iowa City, Iowa, Forenede Stater, 52246
    - Iowa City VA Healthcare System
  - Mason City, Iowa, Forenede Stater, 50401
    - Mercy Medical Center - North Iowa
  - Sioux City, Iowa, Forenede Stater, 51101
    - Siouxland Regional Cancer Center
  - West Des Moines, Iowa, Forenede Stater, 50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Chanute, Kansas, Forenede Stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forenede Stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas - El Dorado
  - Emporia, Kansas, Forenede Stater, 66801
    - Newman Regional Health
  - Fort Scott, Kansas, Forenede Stater, 66701
    - Cancer Center of Kansas - Fort Scott
  - Garden City, Kansas, Forenede Stater, 67846
    - Saint Catherine Hospital
  - Great Bend, Kansas, Forenede Stater, 67530
    - Saint Rose Ambulatory and Surgery Center
  - Hays, Kansas, Forenede Stater, 67601
    - Hays Medical Center
  - Independence, Kansas, Forenede Stater, 67301
    - Cancer Center of Kansas-Independence
  - Kansas City, Kansas, Forenede Stater, 66160
    - University of Kansas Cancer Center
  - Kansas City, Kansas, Forenede Stater, 66112
    - University of Kansas Cancer Center-West
  - Kingman, Kansas, Forenede Stater, 67068
    - Cancer Center of Kansas-Kingman
  - Liberal, Kansas, Forenede Stater, 67905
    - Cancer Center of Kansas-Liberal
  - Newton, Kansas, Forenede Stater, 67114
    - Cancer Center of Kansas - Newton
  - Olathe, Kansas, Forenede Stater, 66061
    - Olathe Medical Center
  - Overland Park, Kansas, Forenede Stater, 66210
    - University of Kansas Cancer Center-Overland Park
  - Overland Park, Kansas, Forenede Stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forenede Stater, 66213
    - Saint Luke's South Hospital
  - Parsons, Kansas, Forenede Stater, 67357
    - Cancer Center of Kansas - Parsons
  - Pittsburg, Kansas, Forenede Stater, 66762
    - Via Christi Hospital-Pittsburg
  - Pratt, Kansas, Forenede Stater, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Forenede Stater, 67401
    - Salina Regional Health Center
  - Salina, Kansas, Forenede Stater, 67401
    - Cancer Center of Kansas - Salina
  - Topeka, Kansas, Forenede Stater, 66606
    - Saint Francis Hospital and Medical Center - Topeka
  - Wellington, Kansas, Forenede Stater, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Forenede Stater, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas - Wichita
  - Winfield, Kansas, Forenede Stater, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Lexington, Kentucky, Forenede Stater, 40509
    - Saint Joseph Hospital East
- Louisiana
  - Alexandria, Louisiana, Forenede Stater, 71301
    - Christus Saint Frances Cabrini Hospital
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Ochsner Health Center-Summa
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Hematology/Oncology Clinic LLP
  - Kenner, Louisiana, Forenede Stater, 70065
    - Ochsner Medical Center Kenner
  - Metairie, Louisiana, Forenede Stater, 70006
    - East Jefferson General Hospital
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Medical Center Jefferson
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Tulane University Health Sciences Center
- Maine
  - Augusta, Maine, Forenede Stater, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Forenede Stater, 04401
    - Eastern Maine Medical Center
  - Brewer, Maine, Forenede Stater, 04412
    - Lafayette Family Cancer Center-EMMC
  - Rockport, Maine, Forenede Stater, 04856
    - Penobscot Bay Medical Center
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Forenede Stater, 21201
    - University of Maryland/Greenebaum Cancer Center
  - Frederick, Maryland, Forenede Stater, 21701
    - Frederick Memorial Hospital
  - Olney, Maryland, Forenede Stater, 20832
    - Montgomery General Hospital-Olney
  - Westminster, Maryland, Forenede Stater, 21157
    - William E Kahlert Regional Cancer Center/Sinai Hospital
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02111
    - Tufts Medical Center
  - Fitchburg, Massachusetts, Forenede Stater, 01420
    - Simonds-Sinon Regional Cancer Center
  - Newton, Massachusetts, Forenede Stater, 02462
    - Newton-Wellesley Hospital
  - Springfield, Massachusetts, Forenede Stater, 01199
    - Baystate Medical Center
  - Worcester, Massachusetts, Forenede Stater, 01655
    - University of Massachusetts Medical School
- Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48106-0995
    - Saint Joseph Mercy Hospital
  - Ann Arbor, Michigan, Forenede Stater, 48109
    - University of Michigan Comprehensive Cancer Center
  - Detroit, Michigan, Forenede Stater, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Forenede Stater, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Escanaba, Michigan, Forenede Stater, 49829
    - Green Bay Oncology - Escanaba
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Spectrum Health at Butterworth Campus
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Mercy Health Saint Mary's
  - Iron Mountain, Michigan, Forenede Stater, 49801
    - Green Bay Oncology - Iron Mountain
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - West Michigan Cancer Center
  - Lansing, Michigan, Forenede Stater, 48912
    - Sparrow Hospital
  - Livonia, Michigan, Forenede Stater, 48154
    - Saint Mary Mercy Hospital
  - Reed City, Michigan, Forenede Stater, 49677
    - Spectrum Health Reed City Hospital
  - Saginaw, Michigan, Forenede Stater, 48601
    - Saint Mary's of Michigan
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
- Minnesota
  - Bemidji, Minnesota, Forenede Stater, 56601
    - Sanford Clinic North-Bemidgi
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy Hospital
  - Duluth, Minnesota, Forenede Stater, 55805
    - Saint Luke's Hospital of Duluth
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Cancer Center
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview-Southdale Hospital
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fridley, Minnesota, Forenede Stater, 55432
    - Unity Hospital
  - Mankato, Minnesota, Forenede Stater, 56001
    - Mayo Clinic Health Systems-Mankato
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55454
    - Health Partners Inc
  - Minneapolis, Minnesota, Forenede Stater, 55417
    - Minneapolis Veterans Medical Center
  - Rochester, Minnesota, Forenede Stater, 55905
    - Mayo Clinic
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Coborn Cancer Center at Saint Cloud Hospital
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital
  - Shakopee, Minnesota, Forenede Stater, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Forenede Stater, 55082
    - Lakeview Hospital
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
- Mississippi
  - Corinth, Mississippi, Forenede Stater, 38834
    - The West Clinic - Corinth
- Missouri
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Southeast Cancer Center
  - Chesterfield, Missouri, Forenede Stater, 63017
    - Saint Luke's Hospital
  - Columbia, Missouri, Forenede Stater, 65212
    - University of Missouri - Ellis Fischel
  - Creve Coeur, Missouri, Forenede Stater, 63141
    - Barnes-Jewish West County Hospital
  - Jefferson City, Missouri, Forenede Stater, 65109
    - Capital Region Medical Center-Goldschmidt Cancer Center
  - Kansas City, Missouri, Forenede Stater, 64128
    - Kansas City Veterans Affairs Medical Center
  - Kansas City, Missouri, Forenede Stater, 64131
    - The University of Kansas Cancer Center-South
  - Kansas City, Missouri, Forenede Stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forenede Stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forenede Stater, 64108
    - Truman Medical Center
  - Kansas City, Missouri, Forenede Stater, 64154
    - The University of Kansas Cancer Center-North
  - Lee's Summit, Missouri, Forenede Stater, 64086
    - Saint Luke's East - Lee's Summit
  - Lee's Summit, Missouri, Forenede Stater, 64064
    - The University of Kansas Cancer Center-Lee's Summit
  - Saint Louis, Missouri, Forenede Stater, 63110
    - Washington University School of Medicine
  - Saint Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Medical Center
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Mercy Hospital Saint Louis
  - Springfield, Missouri, Forenede Stater, 65804
    - Mercy Hospital Springfield
- Montana
  - Anaconda, Montana, Forenede Stater, 59711
    - Community Hospital of Anaconda
  - Billings, Montana, Forenede Stater, 59101
    - Saint Vincent Healthcare
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Deaconess Hospital
  - Butte, Montana, Forenede Stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Forenede Stater, 59405
    - Benefis Healthcare- Sletten Cancer Institute
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Regional Medical Center
- Nebraska
  - Grand Island, Nebraska, Forenede Stater, 68803
    - CHI Health Saint Francis
  - Kearney, Nebraska, Forenede Stater, 68847
    - CHI Health Good Samaritan
  - Lincoln, Nebraska, Forenede Stater, 68506
    - Nebraska Hematology and Oncology
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Southeast Nebraska Cancer Center
  - Omaha, Nebraska, Forenede Stater, 68114
    - Nebraska Methodist Hospital
- Nevada
  - Las Vegas, Nevada, Forenede Stater, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Forenede Stater, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Forenede Stater, 89113
    - HealthCare Partners Medical Group Oncology/Hematology-San Martin
  - Las Vegas, Nevada, Forenede Stater, 89128
    - HealthCare Partners Medical Group Oncology/Hematology-Tenaya
- New Hampshire
  - Concord, New Hampshire, Forenede Stater, 03301
    - New Hampshire Oncology Hematology PA-Concord
  - Dover, New Hampshire, Forenede Stater, 03820
    - Wentworth-Douglass Hospital
  - Hooksett, New Hampshire, Forenede Stater, 03106
    - New Hampshire Oncology Hematology PA-Hooksett
  - Laconia, New Hampshire, Forenede Stater, 03246
    - LRGHealthcare-Lakes Region General Hospital
  - Lebanon, New Hampshire, Forenede Stater, 03756
    - Dartmouth Hitchcock Medical Center
  - Manchester, New Hampshire, Forenede Stater, 03102
    - Norris Cotton Cancer Center-Manchester
  - Nashua, New Hampshire, Forenede Stater, 03063
    - Norris Cotton Cancer Center-Nashua
  - Nashua, New Hampshire, Forenede Stater, 03060
    - Saint Joseph Hospital
  - Portsmouth, New Hampshire, Forenede Stater, 03802
    - Portsmouth Regional Hospital
- New Jersey
  - Basking Ridge, New Jersey, Forenede Stater, 07920
    - Memorial Sloan Kettering Cancer Center at Basking Ridge
  - East Orange, New Jersey, Forenede Stater, 07018-1095
    - Veterans Adminstration New Jersey Health Care System
  - Hackensack, New Jersey, Forenede Stater, 07601
    - Hackensack University Medical Center
  - Mount Holly, New Jersey, Forenede Stater, 08060
    - Virtua Memorial
  - Paramus, New Jersey, Forenede Stater, 07652
    - The Valley Hospital-Luckow Pavilion
  - Voorhees, New Jersey, Forenede Stater, 08043
    - Virtua Voorhees
  - Westwood, New Jersey, Forenede Stater, 07675
    - Valley Health System-Hematology/Oncology
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - University of New Mexico Cancer Center
  - Las Cruces, New Mexico, Forenede Stater, 88011
    - Memorial Medical Center - Las Cruces
  - Santa Fe, New Mexico, Forenede Stater, 87505
    - Christus Saint Vincent Regional Cancer Center
- New York
  - Bronx, New York, Forenede Stater, 10461
    - Montefiore Medical Center-Einstein Campus
  - Bronx, New York, Forenede Stater, 10467-2490
    - Montefiore Medical Center - Moses Campus
  - Bronx, New York, Forenede Stater, 10468
    - Bronx Veterans Administration Medical Center
  - Brooklyn, New York, Forenede Stater, 11219
    - Maimonides Medical Center
  - Brooklyn, New York, Forenede Stater, 11203
    - Kings County Hospital
  - Buffalo, New York, Forenede Stater, 14263
    - Roswell Park Cancer Institute
  - Buffalo, New York, Forenede Stater, 14215
    - Veterans Affairs Western New York Health Care System-Buffalo
  - Commack, New York, Forenede Stater, 11725
    - Memorial Sloan Kettering Cancer Center Commack
  - Elmira, New York, Forenede Stater, 14905
    - Arnot Ogden Medical Center/Falck Cancer Center
  - Harrison, New York, Forenede Stater, 10604
    - Memorial Sloan-Kettering Cancer Center West Harrison
  - New Hyde Park, New York, Forenede Stater, 11040
    - North Shore-LIJ Health System/Center for Advanced Medicine
  - New York, New York, Forenede Stater, 10065
    - Memorial Sloan-Kettering Cancer Center
  - New York, New York, Forenede Stater, 10065
    - Weill Medical College of Cornell University
  - New York, New York, Forenede Stater, 10016
    - Laura and Isaac Perlmutter Cancer Center at NYU Langone
  - New York, New York, Forenede Stater, 10032
    - Columbia University/Herbert Irving Cancer Center
  - Rochester, New York, Forenede Stater, 14642
    - University of Rochester
  - Rockville Centre, New York, Forenede Stater, 11570
    - Memorial Sloan Kettering Cancer Center Rockville Centre
  - Sleepy Hollow, New York, Forenede Stater, 10591
    - Memorial Sloan Kettering Cancer Center Sleepy Hollow
  - Stony Brook, New York, Forenede Stater, 11794
    - Stony Brook University Medical Center
  - Syracuse, New York, Forenede Stater, 13210
    - State University of New York Upstate Medical University
  - Syracuse, New York, Forenede Stater, 13210
    - Syracuse Veterans Administration Medical Center
- North Carolina
  - Asheboro, North Carolina, Forenede Stater, 27203
    - Randolph Hospital
  - Burlington, North Carolina, Forenede Stater, 27215
    - Cone Health Cancer Center at Alamance Regional
  - Chapel Hill, North Carolina, Forenede Stater, 27599
    - UNC Lineberger Comprehensive Cancer Center
  - Charlotte, North Carolina, Forenede Stater, 28204
    - Novant Health Presbyterian Medical Center
  - Charlotte, North Carolina, Forenede Stater, 28207
    - Oncology Specialists of Charlotte
  - Charlotte, North Carolina, Forenede Stater, 28262
    - Southern Oncology Specialists-Charlotte
  - Durham, North Carolina, Forenede Stater, 27710
    - Duke University Medical Center
  - Durham, North Carolina, Forenede Stater, 27705
    - Durham Veterans Affairs Medical Center
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Memorial Hospital
  - Greensboro, North Carolina, Forenede Stater, 27403
    - Cone Health Cancer Center
  - Huntersville, North Carolina, Forenede Stater, 28078
    - Southern Oncology Specialists-Huntersville
  - Huntersville, North Carolina, Forenede Stater, 28078
    - Lake Norman Hematology Oncology Specialists-Huntersville
  - Kernersville, North Carolina, Forenede Stater, 27284
    - Novant Health Oncology Specialists-Kernersville
  - Kinston, North Carolina, Forenede Stater, 28501
    - Kinston Medical Specialists PA
  - Matthews, North Carolina, Forenede Stater, 28105
    - Novant Health Cancer Specialists-Matthews
  - Mooresville, North Carolina, Forenede Stater, 28117
    - Lake Norman Hematology Oncology Specialists-Mooresville
  - Mount Airy, North Carolina, Forenede Stater, 27030
    - Novant Health Oncology Specialists-Mount Airy
  - Reidsville, North Carolina, Forenede Stater, 27320
    - Annie Penn Memorial Hospital
  - Salisbury, North Carolina, Forenede Stater, 28144
    - Carolina Oncology Associates PA
  - Salisbury, North Carolina, Forenede Stater, 28144
    - Veterans Administration Medical Center
  - Statesville, North Carolina, Forenede Stater, 28625
    - Novant Health Oncology Specialists-Statesville
  - Thomasville, North Carolina, Forenede Stater, 27360
    - Novant Health Oncology Specialists-Davidson County
  - Washington, North Carolina, Forenede Stater, 27889
    - Marion L Shepard Cancer Center at Vidant Beaufort Hospital
  - Wilkesboro, North Carolina, Forenede Stater, 28659
    - Novant Health Oncology Specialists-Wilkesboro
  - Winston-Salem, North Carolina, Forenede Stater, 27157
    - Wake Forest University Health Sciences
  - Winston-Salem, North Carolina, Forenede Stater, 27103
    - Novant Health Forsyth Medical Center
  - Winston-Salem, North Carolina, Forenede Stater, 27103
    - Novant Health Oncology Specialists
  - Winston-Salem, North Carolina, Forenede Stater, 27103
    - Winston-Salem Health Care
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Sanford Bismarck Medical Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Clinic North-Fargo
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Medical Center-Fargo
  - Grand Forks, North Dakota, Forenede Stater, 58201
    - Altru Cancer Center
  - Minot, North Dakota, Forenede Stater, 58701
    - Trinity Cancer Care Center
- Ohio
  - Akron, Ohio, Forenede Stater, 44304
    - Summa Akron City Hospital/Cooper Cancer Center
  - Barberton, Ohio, Forenede Stater, 44203
    - Summa Barberton Hospital
  - Beachwood, Ohio, Forenede Stater, 44122
    - UHHS-Chagrin Highlands Medical Center
  - Canton, Ohio, Forenede Stater, 44708
    - Mercy Medical Center
  - Centerville, Ohio, Forenede Stater, 45459
    - Dayton Physicians LLC-Miami Valley South
  - Chardon, Ohio, Forenede Stater, 44024
    - Geaugra Hospital
  - Cincinnati, Ohio, Forenede Stater, 45219
    - University of Cincinnati/Barrett Cancer Center
  - Cleveland, Ohio, Forenede Stater, 44106
    - Case Western Reserve University
  - Cleveland, Ohio, Forenede Stater, 44109
    - MetroHealth Medical Center
  - Cleveland, Ohio, Forenede Stater, 44195
    - Cleveland Clinic Foundation
  - Cleveland, Ohio, Forenede Stater, 44111
    - Cleveland Clinic Cancer Center/Fairview Hospital
  - Columbus, Ohio, Forenede Stater, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Forenede Stater, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel Health Center West
  - Dayton, Ohio, Forenede Stater, 45406
    - Good Samaritan Hospital - Dayton
  - Dayton, Ohio, Forenede Stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Samaritan North Health Center
  - Elyria, Ohio, Forenede Stater, 44035
    - Mercy Cancer Center-Elyria
  - Elyria, Ohio, Forenede Stater, 44035
    - Hematology Oncology Center Incorporated
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Hospital
  - Findlay, Ohio, Forenede Stater, 45840
    - Armes Family Cancer Center
  - Findlay, Ohio, Forenede Stater, 45840
    - Orion Cancer Care
  - Independence, Ohio, Forenede Stater, 44131
    - Cleveland Clinic Cancer Center Independence
  - Kettering, Ohio, Forenede Stater, 45409
    - Greater Dayton Cancer Center
  - Mansfield, Ohio, Forenede Stater, 44906
    - Cleveland Clinic Cancer Center Mansfield
  - Maumee, Ohio, Forenede Stater, 43537
    - Toledo Clinic Cancer Centers-Maumee
  - Mayfield Heights, Ohio, Forenede Stater, 44124
    - Hillcrest Hospital Cancer Center
  - Mayfield Heights, Ohio, Forenede Stater, 44124
    - Ireland Cancer Center Landerbrook Health Center
  - Medina, Ohio, Forenede Stater, 44256
    - Summa Health Center at Lake Medina
  - Mentor, Ohio, Forenede Stater, 44060
    - Lake University Ireland Cancer Center
  - Middleburg Heights, Ohio, Forenede Stater, 44130
    - Southwest General Health Center Ireland Cancer Center
  - Parma, Ohio, Forenede Stater, 44129
    - University Hospitals Parma Medical Center
  - Portsmouth, Ohio, Forenede Stater, 45662
    - Southern Ohio Medical Center
  - Sandusky, Ohio, Forenede Stater, 44870
    - North Coast Cancer Care
  - Sandusky, Ohio, Forenede Stater, 44870
    - Ireland Cancer Center at Firelands Regional Medical Center
  - Strongsville, Ohio, Forenede Stater, 44136
    - Cleveland Clinic Cancer Center Strongsville
  - Toledo, Ohio, Forenede Stater, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Toledo, Ohio, Forenede Stater, 43614
    - University of Toledo
  - Wadsworth, Ohio, Forenede Stater, 44281
    - University Hospitals Sharon Health Center
  - Warrensville Heights, Ohio, Forenede Stater, 44122
    - South Pointe Hospital
  - West Chester, Ohio, Forenede Stater, 45069
    - University Pointe
  - Westerville, Ohio, Forenede Stater, 43081
    - Saint Ann's Hospital
  - Westlake, Ohio, Forenede Stater, 44145
    - UHHS-Westlake Medical Center
  - Westlake, Ohio, Forenede Stater, 44145
    - UH-Seidman Cancer Center at Saint John Medical Center
  - Wooster, Ohio, Forenede Stater, 44691
    - Cleveland Clinic Wooster Family Health and Surgery Center
  - Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433-5529
    - Wright-Patterson Medical Center
- Oklahoma
  - Lawton, Oklahoma, Forenede Stater, 73505
    - Cancer Centers of Southwest Oklahoma Research
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Mercy Hospital Oklahoma City
  - Tulsa, Oklahoma, Forenede Stater, 74146
    - Oklahoma Cancer Specialists and Research Institute-Tulsa
- Oregon
  - Corvallis, Oregon, Forenede Stater, 97330
    - Good Samaritan Hospital
  - Milwaukie, Oregon, Forenede Stater, 97222
    - Providence Milwaukie Hospital
  - Newberg, Oregon, Forenede Stater, 97132
    - Providence Newberg Medical Center
  - Oregon City, Oregon, Forenede Stater, 97045
    - Providence Willamette Falls Medical Center
  - Portland, Oregon, Forenede Stater, 97210
    - Legacy Good Samaritan Hospital and Medical Center
  - Portland, Oregon, Forenede Stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - Providence Saint Vincent Medical Center
  - Portland, Oregon, Forenede Stater, 97227
    - Kaiser Permanente Northwest
- Pennsylvania
  - Abington, Pennsylvania, Forenede Stater, 19001
    - Abington Memorial Hospital
  - Allentown, Pennsylvania, Forenede Stater, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Bethlehem, Pennsylvania, Forenede Stater, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Danville, Pennsylvania, Forenede Stater, 17822
    - Geisinger Medical Center
  - Gettysburg, Pennsylvania, Forenede Stater, 17325
    - Adams Cancer Center
  - Langhorne, Pennsylvania, Forenede Stater, 19047
    - Saint Mary Medical and Regional Cancer Center
  - Natrona Heights, Pennsylvania, Forenede Stater, 15065
    - Allegheny Valley Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15212
    - Allegheny General Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - University of Pittsburgh Cancer Institute (UPCI)
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Hospital
- Rhode Island
  - Providence, Rhode Island, Forenede Stater, 02908
    - Roger Williams Medical Center
- South Carolina
  - Charleston, South Carolina, Forenede Stater, 29401
    - Roper Hospital
  - Charleston, South Carolina, Forenede Stater, 29403
    - Charleston Hematology Oncology Associates-Roper
  - Charleston, South Carolina, Forenede Stater, 29406
    - Lowcountry Hematology Oncology PA-North Charleston
  - Charleston, South Carolina, Forenede Stater, 29414
    - Bon Secours Saint Francis Hospital
  - Charleston, South Carolina, Forenede Stater, 29414
    - Charleston Hematology Oncology Associates PA-St. Francis
  - Charleston, South Carolina, Forenede Stater, 29414
    - Lowcountry Hematology Oncology PA-West Ashley
  - Easley, South Carolina, Forenede Stater, 29640
    - Greenville Health System Cancer Institute-Easley
  - Greenville, South Carolina, Forenede Stater, 29607
    - Saint Francis Cancer Center
  - Greenville, South Carolina, Forenede Stater, 29601
    - Saint Francis Hospital
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Health System Cancer Institute-Faris
  - Greenville, South Carolina, Forenede Stater, 29615
    - Greenville Health System Cancer Institute-Eastside
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Health System Cancer Institute-Butternut
  - Greer, South Carolina, Forenede Stater, 29650
    - Greenville Health System Cancer Institute-Greer
  - Lancaster, South Carolina, Forenede Stater, 29720
    - Carolina Blood and Cancer Care Associates PA-Lancaster
  - Mount Pleasant, South Carolina, Forenede Stater, 29464
    - Lowcountry Hematology Oncology PA-Mount Pleasant
  - Seneca, South Carolina, Forenede Stater, 29672
    - Greenville Health System Cancer Institute-Seneca
  - Spartanburg, South Carolina, Forenede Stater, 29307
    - Greenville Health System Cancer Institute-Spartanburg
- South Dakota
  - Aberdeen, South Dakota, Forenede Stater, 57401
    - Avera Cancer Institute-Aberdeen
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sanford Cancer Center-Oncology Clinic
- Tennessee
  - Germantown, Tennessee, Forenede Stater, 38138
    - The West Clinic - Wolf River
  - Memphis, Tennessee, Forenede Stater, 38163
    - University of Tennessee Health Science Center
- Texas
  - Dallas, Texas, Forenede Stater, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, Forenede Stater, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - Fort Worth, Texas, Forenede Stater, 76104
    - UT Southwestern/Simmons Cancer Center-Fort Worth
  - Galveston, Texas, Forenede Stater, 77555-0565
    - University of Texas Medical Branch
  - Houston, Texas, Forenede Stater, 77030
    - Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
  - Houston, Texas, Forenede Stater, 77030
    - Ben Taub General Hospital
  - League City, Texas, Forenede Stater, 77573
    - UTMB Cancer Center at Victory Lakes
  - San Antonio, Texas, Forenede Stater, 78229
    - University of Texas Health Science Center at San Antonio
- Vermont
  - Burlington, Vermont, Forenede Stater, 05405
    - University of Vermont College of Medicine
  - White River Junction, Vermont, Forenede Stater, 05009
    - White River Junction Veteran Administration Medical Center
- Virginia
  - Charlottesville, Virginia, Forenede Stater, 22908
    - University of Virginia Cancer Center
  - Hampton, Virginia, Forenede Stater, 23666
    - Virginia Oncology Associates-Hampton
  - Lynchburg, Virginia, Forenede Stater, 24501
    - Lynchburg Hematology-Oncology Clinic
  - Martinsville, Virginia, Forenede Stater, 24115
    - Memorial Hospital Of Martinsville
  - Mechanicsville, Virginia, Forenede Stater, 23116
    - Bon Secours Memorial Regional Medical Center
  - Midlothian, Virginia, Forenede Stater, 23114
    - Bon Secours Saint Francis Medical Center
  - Richmond, Virginia, Forenede Stater, 23298
    - Virginia Commonwealth University/Massey Cancer Center
  - Richmond, Virginia, Forenede Stater, 23230
    - Virginia Cancer Institute
  - Winchester, Virginia, Forenede Stater, 22601
    - Shenandoah Oncology Associates PC
- Washington
  - Bellingham, Washington, Forenede Stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Everett, Washington, Forenede Stater, 98201
    - Providence Regional Cancer Partnership
  - Issaquah, Washington, Forenede Stater, 98029
    - Swedish Cancer Institute-Issaquah
  - Poulsbo, Washington, Forenede Stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Seattle, Washington, Forenede Stater, 98104
    - Minor and James Medical PLLC
  - Seattle, Washington, Forenede Stater, 98122-4307
    - Swedish Medical Center-First Hill
- West Virginia
  - Charleston, West Virginia, Forenede Stater, 25304
    - West Virginia University Charleston
  - Huntington, West Virginia, Forenede Stater, 25702
    - Saint Mary's Medical Center
- Wisconsin
  - Antigo, Wisconsin, Forenede Stater, 54409
    - Langlade Hospital and Cancer Center
  - Burlington, Wisconsin, Forenede Stater, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Mayo Clinic Health System-Eau Claire Clinic
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Sacred Heart Hospital
  - Fond Du Lac, Wisconsin, Forenede Stater, 54935
    - Saint Agnes Hospital/Agnesian Cancer Center
  - Germantown, Wisconsin, Forenede Stater, 53022
    - Aurora Health Care Germantown Health Center
  - Grafton, Wisconsin, Forenede Stater, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Forenede Stater, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Forenede Stater, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Green Bay Oncology Limited at Saint Mary's Hospital
  - Green Bay, Wisconsin, Forenede Stater, 54301-3526
    - Green Bay Oncology at Saint Vincent Hospital
  - Janesville, Wisconsin, Forenede Stater, 53547
    - Mercy Health System
  - Kenosha, Wisconsin, Forenede Stater, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Medical Center
  - Madison, Wisconsin, Forenede Stater, 53792
    - University of Wisconsin Hospital and Clinics
  - Madison, Wisconsin, Forenede Stater, 53705
    - William S Middleton VA Medical Center
  - Manitowoc, Wisconsin, Forenede Stater, 54221
    - Holy Family Memorial Hospital
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Vince Lombardi Cancer Clinic-Marinette
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Clinic
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Saint Joseph's Hospital
  - Milwaukee, Wisconsin, Forenede Stater, 53226
    - Froedtert and the Medical College of Wisconsin
  - Milwaukee, Wisconsin, Forenede Stater, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53233
    - Aurora Sinai Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53295
    - Zablocki Veterans Administration Medical Center
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Clinic-Minocqua Center
  - Mukwonago, Wisconsin, Forenede Stater, 53149
    - ProHealth D N Greenwald Center
  - Oconomowoc, Wisconsin, Forenede Stater, 53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oconto Falls, Wisconsin, Forenede Stater, 54154
    - Green Bay Oncology - Oconto Falls
  - Oshkosh, Wisconsin, Forenede Stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forenede Stater, 53406
    - Aurora Cancer Care-Racine
  - Racine, Wisconsin, Forenede Stater, 53405
    - Wheaton Franciscan Cancer Care - All Saints
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Clinic-Rice Lake Center
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - HSHS Saint Nicholas Hospital
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Saint Michael's Hospital
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Marshfield Clinic Cancer Care at Saint Michael's Hospital
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235
    - Green Bay Oncology - Sturgeon Bay
  - Summit, Wisconsin, Forenede Stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forenede Stater, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - ProHealth Waukesha Memorial Hospital
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - Aurora Cancer Care-Waukesha
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Aspirus Regional Cancer Center
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - West Allis, Wisconsin, Forenede Stater, 53227
    - Aurora West Allis Medical Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Diagnostic and Treatment Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Clinic - Weston Center
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Aspirus UW Cancer Center
Puerto Rico
- - San Juan, Puerto Rico, 00936
    - San Juan City Hospital
  - San Juan, Puerto Rico, 00927
    - Fundacion De Investigacion de Diego
  - San Juan, Puerto Rico, 00921-3201
    - San Juan Veterans Affairs Medical Center

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Kvalifikationskriterier:

Dokumentation af sygdom - Progressiv kastrationsresistent metastatisk prostatacancer med histologisk eller cytologisk bekræftet adenocarcinom i prostata uden neuroendokrin differentiering eller småcellede træk
Patienter skal have målbar eller ikke-målbar sygdom:
1. Målbar sygdom - For at viscerale eller ekstra nodale læsioner kan betragtes som målbare, skal de være ≥ 10 mm i én dimension ved brug af spiral-CT. For at lymfeknuder kan betragtes som målbare (dvs. mål- eller evaluerbare læsioner), skal de være ≥ 20 mm i mindst én dimension ved brug af spiral-CT.
2. Ikke-målbar sygdom - Alle andre læsioner, inklusive små læsioner (længste diameter < 20 mm med konventionelle teknikker eller < 10 mm med spiral CT-scanning) og virkelig ikke-målbare læsioner. Læsioner, der anses for ikke-målbare, omfatter (kun) knoglelæsioner.
3. Patienter med kun node-sygdom (dvs. ingen tilstedeværelse af viscerale, ekstra nodale læsioner eller knoglelæsioner) skal have node(r), der måler ≥ 15 mm i kort akse.
Progressiv sygdom - Patienter skal have progressiv sygdom ved studiestart defineret som et eller flere af følgende tre kriterier, der opstod, mens patienten var i behandling med androgendeprivation. For patienter, der indskrives på basis af bløddels- eller knogleprogression, skal baseline-scanningen vise progression i forhold til en sammenligningsscanning. Hvis sammenligningsscanningen ikke er tilgængelig, skal basisscanningsrapporten referere til den tidligere scanning for at dokumentere progression.
1. PSA-progression defineret ved minimum to stigende PSA-niveauer med et interval på ≥ 1 uge mellem hver bestemmelse. Patienter, der fik et anti-androgen, skal have progression dokumenteret ved minimum to stigende PSA-niveauer med et interval på ≥ 1 uge mellem hver bestemmelse, således at mindst den anden af disse stigninger er ≥ 4 uger siden sidste flutamid, bicalutamid eller nilutamid.
  PSA-værdien ved screeningen bør være ≥ 2 µg/L (2 ng/mL).
2. Progression af bløddelssygdom defineret af protokollen
3. Knoglesygdomsprogression defineret af Prostate Cancer Working Group 2 (PCWG2) med to eller flere nye læsioner på knoglescanning
Forudgående behandling
1. Ingen behandling med tidligere taxan-baseret kemoterapi for metastatisk sygdom
  - Patienter, der tidligere har modtaget taxan-baseret kemoterapi som neoadjuverende eller adjuverende terapi for lokal sygdom, eller som modtog taxan-baseret terapi i PSA-klinisk (ikke-metastatisk) tilstand, er tilladt, forudsat at den samlede eksponeringsvarighed var seks cyklusser eller mindre og kemoterapi blev afsluttet mere end 6 måneder før registrering
  - Taxan-baseret kemoterapi, der blev afbrudt på grund af allergiske reaktioner eller intolerance over for kemoterapi og derfor har modtaget én cyklus med forudgående behandling, er tilladt
2. Ingen tidligere enzalutamid, abirateron eller andre nye antiandrogen- eller androgensyntesehæmmere
3. Ingen behandling med nogen af følgende for prostatacancer inden for 4 uger før indskrivning:
  - Hormonbehandling (f.eks. androgenreceptor [AR]-antagonister, 5 alfa-reduktasehæmmere, østrogener) Bemærk: Behandling med bicalutamid og nilutamid inden for 4 uger før tilmelding er ikke tilladt. Behandling med flutamid inden for 4 uger før tilmelding er ikke tilladt. Behandling med alle andre gonadotropin-releasing hormon (GnRH) analoger eller antagonister er tilladt.
  - Kemoterapi
  - Biologisk terapi
  - Udredningsterapi
  - Immunterapi
4. Ingen brug af urteprodukter, der kan reducere PSA-niveauer inden for 4 uger før tilmelding
5. Ingen brug af systemiske steroider, der er større end hvad der svarer til 10 mg prednison/prednisolon om dagen inden for 4 uger før indskrivning
6. Ingen tidligere brug af ketoconazol i mere end 7 dage
7. Ingen forudgående strålebehandling eller radionuklidbehandling til behandling af metastaser inden for fire uger før indskrivning
8. Patienter, der får bisphosphonatbehandling eller denosumab, skal have været på en stabil dosis i mindst 4 uger før indskrivning
9. Patienter skal opretholde igangværende androgen-deprivationsterapi med en GnRH-analog, antagonist eller bilateral orkiektomi (dvs. kirurgisk eller medicinsk kastration)
Patienthistorie
1. Ingen kendte eller mistænkte hjernemetastaser (BEMÆRK: patienter med behandlet epidural sygdom er tilladt)
2. Ingen planlagte palliative procedurer til lindring af knoglesmerter såsom strålebehandling eller kirurgi
3. Ingen strukturelt ustabile knoglelæsioner, der tyder på forestående fraktur
4. Ingen historie med anfald eller nogen tilstand, der kan øge patientens risiko for anfald (f.eks. tidligere kortikalt slagtilfælde, betydelig hjernetraume). Ingen historie med forbigående iskæmisk anfald (TIA) inden for 12 måneder efter indskrivning
5. Ingen klinisk signifikant kardiovaskulær sygdom, herunder:
  - Myokardieinfarkt (MI) inden for 6 måneder
  - Ukontrolleret angina inden for 3 måneder
  - Kongestiv hjertesvigt (CHF) med New York Heart Association (NYHA) klasse 3 eller 4, eller patienter med NYHA klasse 3 eller 4 tidligere, medmindre et screeningekkokardiogram (ekko) eller multigated acquisition scan (MUGA) udført inden for tre måneder viser en ejektionsfraktion (EF) > 45 %
  - Anamnese med klinisk signifikante ventrikulære arytmier (f.eks. ventrikulær takykardi, ventrikulær fibrillation, torsades de pointes)
  - Anamnese med Mobitz II andengrads eller tredjegrads hjerteblokade uden en permanent pacemaker på plads
  - Hypotension (systolisk blodtryk [BP] < 86 mmHg) eller bradykardi (< 50 bpm) ved screening
  - Ukontrolleret hypertension (systolisk BP > 170 mmHg eller diastolisk BP > 105 mmHg ved screening)
6. Ingen gastrointestinal (GI) lidelse, der negativt påvirker absorptionen
7. Ingen større operation inden for 4 uger før tilmelding
Alder og præstationsstatus
1. Alder ≥ 18 år
2. Eastern Cooperative Oncology Group (ECOG) præstationsstatus 0-1
3. Asymptomatisk eller let symptomatisk fra prostatacancer
Påkrævede indledende laboratorieværdier
1. Granulocytter ≥ 1.500/µL
2. Blodpladeantal ≥ 100.000/µL
3. Hæmoglobin ≥ 9 g/dL
4. Kreatinin ≤ 2 x øvre normalgrænse (ULN)
5. Bilirubin ≤ 1,5 x ULN
6. Aspartataminotransferase (AST) eller alaninaminotransferase (ALT) ≤ 2 x ULN
7. Albumin ≥ 3 g/dl
8. Total testosteron ≤ 50 ng/dL (1,7 nmol/L)

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Arm A: (enzalutamid) Patienterne får enzalutamid 160 mg PO QD. Behandlingen vil fortsætte indtil bekræftet sygdomsprogression eller uacceptabel toksicitet.	Medicin: enzalutamid Enzalutamid 160 mg dagligt, oralt
Eksperimentel: Arm B: (enzalutamid, abirateron, prednison) Patienterne får enzalutamid 160 mg PO QD, abirateron 1000 mg PO QD og prednison 5 mg PO BID. Behandlingen vil fortsætte indtil bekræftet sygdomsprogression eller uacceptabel toksicitet.	Medicin: enzalutamid Enzalutamid 160 mg dagligt, oralt Medicin: abirateron abirateron 1000 mg dagligt, oralt Medicin: prednison prednison 5 mg to gange dagligt, oralt

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Samlet overlevelse (OS) Tidsramme: Op til 5 år efter behandling	Samlet overlevelse er defineret som tiden fra undersøgelsesregistrering til død på grund af en hvilken som helst årsag.	Op til 5 år efter behandling

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Antal deltagere, der har oplevet mindst én toksicitet (defineret som en grad 3 eller højere uønsket hændelse, der anses for at være mindst muligt relateret til behandling) Tidsramme: Op til 5 år efter behandling	Antallet af deltagere, der har oplevet mindst én toksicitet (defineret som en uønsket hændelse af grad 3 eller højere, der som minimum anses for at være relateret til behandling)	Op til 5 år efter behandling
Fald i prostataspecifikt antigen (PSA) Tidsramme: Op til 5 år efter behandling		Op til 5 år efter behandling
Progressionsfri overlevelse (PFS) Tidsramme: Op til 5 år efter behandling		Op til 5 år efter behandling
Objektiv svarprocent Tidsramme: Op til 5 år efter behandling		Op til 5 år efter behandling
Radiografisk progressionsfri overlevelse (rPFS) Tidsramme: Op til 5 år efter behandling		Op til 5 år efter behandling
Tumorbelastning og knogleaktivitet Tidsramme: Op til 5 år efter behandling		Op til 5 år efter behandling

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Alliance for Clinical Trials in Oncology

Samarbejdspartnere

National Cancer Institute (NCI)

Astellas Pharma US, Inc.

Medivation, Inc.

Biologics, Inc.

Efterforskere

Studiestol: Michael Morris, M.D., Memorial Sloan Kettering Cancer Center

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

22. januar 2014

Primær færdiggørelse (Faktiske)

2. november 2018

Studieafslutning (Anslået)

31. august 2024

Datoer for studieregistrering

Først indsendt

20. september 2013

Først indsendt, der opfyldte QC-kriterier

20. september 2013

Først opslået (Anslået)

24. september 2013

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

28. september 2023

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

13. september 2023

Sidst verificeret

1. september 2023

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

A031201
U10CA031946 (U.S. NIH-bevilling/kontrakt)
NCI-2013-01737 (Registry Identifier: Clinical Trial Reporting Program)

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Tilbagevendende prostatakræft

Ohio State University
Merck Sharp & Dohme LLC

Ikke rekrutterer endnu

Effektiviteten af en boosterinjektion med Gardasil-9-vaccinen på intersurgicalt interval* hos voksne med recidiverende respiratorisk papillomatose* (*ISI *RRP)

Recurrent Respiratory Papillomatosis (RRP)

Forenede Stater
National Cancer Institute (NCI)

Ikke rekrutterer endnu

Sacituzumab Govitecan med Bevacizumab sammenlignet med sædvanlig kemoterapi (Carboplatin, pegyleret liposomal Doxorubicin og Bevacizumab) til behandling af tilbagevendende platinfølsom æggestokkræft efter PARP-hæmmer vedligeholdelsesterapi

Recidiverende platinfølsomt tuba fallopii højgradigt serøst adenokarcinom | Recidiverende Platinfølsom Ovarie Højgradigt Serøs Adenokarcinom | Recurrent Platinum-Sensitive Primary Peritoneal High Grade Serous Adenocarcinoma | Recurrent Platinum-Sensitive Endometrioid Adenokarcinom i Æggelederen og andre forhold

Kliniske forsøg med enzalutamid

ESSA Pharmaceuticals

Afsluttet

EPI-7386 i kombination med enzalutamid sammenlignet med enzalutamid alene hos forsøgspersoner med mCRPC

Prostatakræft

Forenede Stater, Canada, Australien
Alessa Therapeutics Inc.
National Cancer Institute (NCI)

Rekruttering

Enzalutamidimplantater (Enolen) hos patienter med prostatakræft

Prostata Adenocarcinom

Forenede Stater
Astellas Pharma Europe B.V.
Medivation, Inc.

Afsluttet

Relativ biotilgængelighedsundersøgelse af enzalutamid hos prostatacancerpatienter

Prostatakræft | Enzalutamids farmakokinetik

Forenede Stater
Cancer Trials Ireland

Afsluttet

Radium-223 i kombination med enzalutamid

Prostatakræft

Irland
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI); Astellas Pharma US, Inc.

Aktiv, ikke rekrutterende

Enzalutamid til patienter med androgenreceptorpositiv spytkræft

Spytkræft

Forenede Stater
Groupe Hospitalier Pitie-Salpetriere

Afsluttet

en Vigibase Pharmacovigilance undersøgelse af ENzalutamid-lægemiddelinduceret neurotoksicitet (VENDY)

Epilepsi | Prostatakræft | Neuropati | Encefalopati

Frankrig
Radboud University Medical Center

Afsluttet

Effekt af en reduceret dosis enzalutamid hos svage (m)CRPC-patienter på kognitive bivirkninger (REDOSE)

Prostatiske neoplasmer, kastrationsresistente

Holland
Fundación Canaria de Investigación Sanitaria
Hospital Universitario de Canarias

Ukendt

Enzalutamid og ekstern strålehypofraktioneret strålebehandling til lokaliseret prostatakræft med middel risiko (ENZART)

Prostata karcinom

Spanien
CHU de Quebec-Universite Laval
Astellas Pharma Europe Ltd.

Aktiv, ikke rekrutterende

Påvisning af metastaser ved PyL PET/CT hos forsøgspersoner, der starter med enzalutamid til ubehandlet kastrationsresistent prostatakræft. (PROSTEP-002)

Prostatakræft

Canada
Translational Research Center for Medical Innovation...
Kagawa University

Afsluttet

Japansk forskning for patienter med ikke-metastatisk kastrationsresistent prostatakræft - Enzalutamid (JCASTRE-Zero)

Prostatakræft

Japan

Enzalutamid med eller uden abirateron og prednison til behandling af patienter med kastrationsresistent metastatisk prostatakræft

Fase III-forsøg med Enzalutamid (NSC# 766085) versus Enzalutamid, Abiraterone og Prednison til kastrationsresistent metastatisk prostatakræft

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Faktiske)

Studieafslutning (Anslået)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Anslået)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Kliniske forsøg med Tilbagevendende prostatakræft

Kliniske forsøg med enzalutamid

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Panama

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer