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Undersøgelse for at vurdere effektiviteten og sikkerheden af ​​PT010 i forhold til PT003 og PT009 hos forsøgspersoner med moderat til meget svær KOL (Ethos)

1. februar 2021 opdateret af: Pearl Therapeutics, Inc.

Et randomiseret, dobbeltblindt, multicenter, parallelgruppestudie for at vurdere effektiviteten og sikkerheden af ​​PT010 i forhold til PT003 og PT009 om KOL-eksacerbationer over en 52-ugers behandlingsperiode hos forsøgspersoner med moderat til meget svær KOL (etos)

Dette er et randomiseret, dobbeltblindt, multicenter, parallelgruppestudie til at vurdere effektiviteten og sikkerheden af ​​PT010 i forhold til PT003 og PT009 på KOL-eksacerbationspersoner med moderat til meget svær KOL.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Et randomiseret, dobbeltblindt, multicenter, parallelgruppestudie til vurdering af effektiviteten og sikkerheden af ​​PT010 i forhold til PT003 og PT009 på KOL-eksacerbationer over en 52-ugers behandlingsperiode hos forsøgspersoner med moderat til meget svær KOL.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

8588

Fase

  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Argentina
      • Buenos Aires, Argentina, C1414AIF
        • Research Site
      • Buenos Aires, Argentina, C1121ABE
        • Research Site
      • Buenos Aires, Argentina, C1425BEN
        • Research Site
      • Buenos Aires, Argentina, 1015
        • Research Site
      • Caba, Argentina, C1056ABJ
        • Research Site
      • Capital Federal, Argentina, C1122AAK
        • Research Site
      • Ciudad Autonoma de Buenos Aire, Argentina, C1120AAC
        • Research Site
      • Ciudad Autonoma de Buenos Aire, Argentina, C1028AAP
        • Research Site
      • Ciudad Autonomade Buenos Aires, Argentina, 1426
        • Research Site
      • Ciudad Autónoma de Bs. As., Argentina, 1426
        • Research Site
      • Ciudad Capital, Argentina, 5500
        • Research Site
      • Ciudad de Buenos Aire, Argentina, C1425BEN
        • Research Site
      • Cordoba, Argentina, X5008HHW
        • Research Site
      • Córdoba, Argentina, X5003DCE
        • Research Site
      • Florencio Varela, Argentina, 1888
        • Research Site
      • Florida, Argentina, B1602DQD
        • Research Site
      • La Plata, Argentina, 1900
        • Research Site
      • Lanus, Argentina, B1824KAJ
        • Research Site
      • Mar del Plata, Argentina, 7600
        • Research Site
      • Mar del Plata, Argentina, B7600FZN
        • Research Site
      • Mendoza, Argentina, 5500
        • Research Site
      • Mendoza, Argentina, M5500GIP
        • Research Site
      • Mendoza, Argentina, M5500GPD
        • Research Site
      • Monte Grande, Argentina, 1842
        • Research Site
      • Paraná, Argentina, E3100XAI
        • Research Site
      • Quilmes, Argentina, B1878FNR
        • Research Site
      • Rosario, Argentina, 2000
        • Research Site
      • Rosario, Argentina, S2000DEJ
        • Research Site
      • Rosario, Argentina, 2002
        • Research Site
      • San Fernando, Argentina, 1646
        • Research Site
      • San Miguel de Tucuman, Argentina, 4000
        • Research Site
      • San Miguel de Tucumán, Argentina, T4000IAR
        • Research Site
      • Santa Fe, Argentina, S3000FWO
        • Research Site
      • Santa Fe, Argentina, S3000ASF
        • Research Site
      • Santa Rosa, Argentina, L6300EAN
        • Research Site
  • Australien
      • Adelaide, Australien, 5000
        • Research Site
      • Bedford Park, Australien, 5042
        • Research Site
      • Box Hill, Australien, 3128
        • Research Site
      • Cairns, Australien, 4870
        • Research Site
      • Concord, Australien, 2139
        • Research Site
      • Everton Park, Australien, 4053
        • Research Site
      • Kent Town, Australien, 5067
        • Research Site
      • Murdoch, Australien, 6150
        • Research Site
      • Nedlands, Australien, 6009
        • Research Site
      • South Brisbane, Australien, 4101
        • Research Site
      • Westmead, Australien, 2145
        • Research Site
  • Belgien
      • Bruxelles, Belgien, 1200
        • Research Site
      • Erpent, Belgien, 5101
        • Research Site
      • Genk, Belgien, 03600
        • Research Site
      • Gilly, Belgien, 6060
        • Research Site
      • Halen, Belgien, 03545
        • Research Site
      • Ham, Belgien, 03945
        • Research Site
      • Lebbeke, Belgien
        • Research Site
      • Montigny Le Tilleul, Belgien, BE-6110
        • Research Site
      • Wetteren, Belgien, 9230
        • Research Site
  • Canada
      • Quebec, Canada, G1G 3Y8
        • Research Site
      • Quebec, Canada, G1V 4G5
        • Research Site
    • Alberta
      • Edmonton, Alberta, Canada, T5A 4L8
        • Research Site
      • Sherwood Park, Alberta, Canada, T8L 0N2
        • Research Site
    • British Columbia
      • Vancouver, British Columbia, Canada, V5X04
        • Research Site
    • CA
      • Vancouver, CA, Canada, V5Z 4E1
        • Research Site
    • Manitoba
      • Winnipeg, Manitoba, Canada, R2K 3S8
        • Research Site
    • Nova Scotia
      • Truro, Nova Scotia, Canada, B2N 1L2
        • Research Site
    • Ontario
      • Ajax, Ontario, Canada, L1S 2J5
        • Research Site
      • Burlington, Ontario, Canada, L7N 3V2
        • Research Site
      • Hamilton, Ontario, Canada, L8N 4A6
        • Research Site
      • Mississauga, Ontario, Canada, L4V 1P1
        • Research Site
      • Sarnia, Ontario, Canada, N7T4X3
        • Research Site
      • Sudbury, Ontario, Canada, P3A 1W8
        • Research Site
      • Windsor, Ontario, Canada, N8X 1T3
        • Research Site
    • Quebec
      • Gatineau, Quebec, Canada, J8Y 6S8
        • Research Site
      • Levis, Quebec, Canada, G6W 0M5
        • Research Site
      • Mirabel, Quebec, Canada, J7J 2K8
        • Research Site
      • Montreal, Quebec, Canada, H1M 1B1
        • Research Site
      • Montreal, Quebec, Canada, H2X 1P1
        • Research Site
      • Pointe-Claire, Quebec, Canada, H9R 3J1
        • Research Site
      • Saint-Jerome, Quebec, Canada, J7Z 5T3
        • Research Site
      • St Charles Borromee, Quebec, Canada, J6E 2B4
        • Research Site
    • Saskatchewan
      • Saskatoon, Saskatchewan, Canada, S7N 0W8
        • Research Site
  • Chile
      • Concepción, Chile, 4070038
        • Research Site
      • Curico, Chile, 3341643
        • Research Site
      • Quillota, Chile, 2260877
        • Research Site
      • Santiago, Chile, 7500698
        • Research Site
      • Santiago, Chile, 8910131
        • Research Site
      • Santiago, Chile, 8207257
        • Research Site
      • Santiago, Chile, 7750495
        • Research Site
      • Santiago, Chile, 8053095
        • Research Site
      • Santiago, Chile, 7500588
        • Research Site
      • Santiago, Chile, 7500692
        • Research Site
      • Talca, Chile, 3465584
        • Research Site
      • Valparaiso, Chile, 2341131
        • Research Site
      • Viña del Mar, Chile, 2520024
        • Research Site
  • Den Russiske Føderation
      • Arkhangelsk, Den Russiske Føderation, 163001
        • Research Site
      • Ekaterinburg, Den Russiske Føderation, 620039
        • Research Site
      • Gatchina, Den Russiske Føderation, 188300
        • Research Site
      • Moscow, Den Russiske Føderation, 119991
        • Research Site
      • Moscow, Den Russiske Føderation, 125315
        • Research Site
      • Moscow, Den Russiske Føderation, 129090
        • Research Site
      • Moscow, Den Russiske Føderation, 117997
        • Research Site
      • Moscow, Den Russiske Føderation, 105229
        • Research Site
      • Moscow, Den Russiske Føderation, 115682
        • Research Site
      • Moscow, Den Russiske Føderation, 121309
        • Research Site
      • Moscow, Den Russiske Føderation, 119002
        • Research Site
      • Saint Petersburg, Den Russiske Føderation
        • Research Site
      • St. Petersburg, Den Russiske Føderation, 197022
        • Research Site
      • St. Petersburg, Den Russiske Føderation, 194356
        • Research Site
  • Det Forenede Kongerige
      • Belfast, Det Forenede Kongerige, BT7 2EB
        • Research Site
      • Birmingham, Det Forenede Kongerige, B9 5SS
        • Research Site
      • Birmingham, Det Forenede Kongerige, B15 2WB
        • Research Site
      • Blackpool, Det Forenede Kongerige, FY3 7EN
        • Research Site
      • Blackpool, Det Forenede Kongerige, FY4 3AD
        • Research Site
      • Bradford, Det Forenede Kongerige, BND9 6RJ
        • Research Site
      • Chesterfield, Det Forenede Kongerige, S40 4AA
        • Research Site
      • Corby, Det Forenede Kongerige, NN17 2UR
        • Research Site
      • Edinburgh, Det Forenede Kongerige, EH16 4SA
        • Research Site
      • Glasgow, Det Forenede Kongerige, G69 7AD
        • Research Site
      • Kenilworth, Det Forenede Kongerige, CV8 1JD
        • Research Site
      • Liverpool, Det Forenede Kongerige, L14 3PE
        • Research Site
      • London, Det Forenede Kongerige, EC1M 6BQ
        • Research Site
      • London, Det Forenede Kongerige, NW3 2PF
        • Research Site
      • Middlesex, Det Forenede Kongerige, HA2 2RN
        • Research Site
      • Norwich, Det Forenede Kongerige, NR4 7TJ
        • Research Site
      • Peterborough, Det Forenede Kongerige, PE8 6PL
        • Research Site
      • Romford, Det Forenede Kongerige, RM1 3PJ
        • Research Site
      • Shipley, Det Forenede Kongerige, BD18 3SA
        • Research Site
      • Sidcup, Det Forenede Kongerige, DA14 6LT
        • Research Site
      • Wokingham, Det Forenede Kongerige, RG40 1XS
        • Research Site
  • Forenede Stater
    • Alabama
      • Andalusia, Alabama, Forenede Stater, 36420
        • Research Site
      • Athens, Alabama, Forenede Stater, 35611
        • Research Site
      • Birmingham, Alabama, Forenede Stater, 35209
        • Research Site
      • Birmingham, Alabama, Forenede Stater, 35243
        • Research Site
      • Birmingham, Alabama, Forenede Stater, 35235
        • Research Site
      • Dothan, Alabama, Forenede Stater, 36303
        • Research Site
      • Florence, Alabama, Forenede Stater, 35630
        • Research Site
      • Foley, Alabama, Forenede Stater, 36535
        • Research Site
      • Gulf Shores, Alabama, Forenede Stater, 36542
        • Research Site
      • Jasper, Alabama, Forenede Stater, 35501
        • Research Site
      • Mobile, Alabama, Forenede Stater, 36608
        • Research Site
      • Montgomery, Alabama, Forenede Stater, 36106
        • Research Site
      • Scottsboro, Alabama, Forenede Stater, 35768
        • Research Site
      • Sheffield, Alabama, Forenede Stater, 35660
        • Research Site
    • Arizona
      • Peoria, Arizona, Forenede Stater, 85381
        • Research Site
      • Phoenix, Arizona, Forenede Stater, 85018
        • Research Site
      • Phoenix, Arizona, Forenede Stater, 85020
        • Research Site
      • Phoenix, Arizona, Forenede Stater, 85012
        • Research Site
      • Scottsdale, Arizona, Forenede Stater, 85258
        • Research Site
    • Arkansas
      • Conway, Arkansas, Forenede Stater, 72032
        • Research Site
      • Little Rock, Arkansas, Forenede Stater, 72209
        • Research Site
      • Little Rock, Arkansas, Forenede Stater, 72205
        • Research Site
      • North Little Rock, Arkansas, Forenede Stater, 72117
        • Research Site
    • California
      • Bakersfield, California, Forenede Stater, 93301
        • Research Site
      • Beverly Hills, California, Forenede Stater, 90212
        • Research Site
      • Cerritos, California, Forenede Stater, 90703
        • Research Site
      • El Cajon, California, Forenede Stater, 92020
        • Research Site
      • Escondido, California, Forenede Stater, 92025
        • Research Site
      • Fresno, California, Forenede Stater, 93702
        • Research Site
      • Gold River, California, Forenede Stater, 95670
        • Research Site
      • Hawaiian Gardens, California, Forenede Stater, 90716
        • Research Site
      • Huntington Beach, California, Forenede Stater, 92647
        • Research Site
      • Huntington Park, California, Forenede Stater, 90255-6046
        • Research Site
      • La Mirada, California, Forenede Stater, 90638
        • Research Site
      • Lakewood, California, Forenede Stater, 90712
        • Research Site
      • Los Angeles, California, Forenede Stater, 90025
        • Research Site
      • Los Angeles, California, Forenede Stater, 90017
        • Research Site
      • Los Angeles, California, Forenede Stater, 90036
        • Research Site
      • Los Angeles, California, Forenede Stater, 90048
        • Research Site
      • Newport Beach, California, Forenede Stater, 92663
        • Research Site
      • Northridge, California, Forenede Stater, 91324
        • Research Site
      • Palm Springs, California, Forenede Stater, 92262
        • Research Site
      • Poway, California, Forenede Stater, 92064
        • Research Site
      • Quartz Hill, California, Forenede Stater, 93536
        • Research Site
      • Rancho Mirage, California, Forenede Stater, 92270
        • Research Site
      • Riverside, California, Forenede Stater, 92506
        • Research Site
      • Rolling Hills Estates, California, Forenede Stater, 90274
        • Research Site
      • Sacramento, California, Forenede Stater, 95821
        • Research Site
      • Sacramento, California, Forenede Stater, 95823
        • Research Site
      • Sacramento, California, Forenede Stater, 95831
        • Research Site
      • San Diego, California, Forenede Stater, 92120
        • Research Site
      • San Diego, California, Forenede Stater, 92117
        • Research Site
      • Santa Ana, California, Forenede Stater, 92705
        • Research Site
      • Santa Ana, California, Forenede Stater, 92704
        • Research Site
      • Santa Monica, California, Forenede Stater, 90404
        • Research Site
      • Stockton, California, Forenede Stater, 95207
        • Research Site
      • Torrance, California, Forenede Stater, 90503
        • Research Site
      • Tustin, California, Forenede Stater, 92780
        • Research Site
      • Upland, California, Forenede Stater, 91786
        • Research Site
      • Westminster, California, Forenede Stater, 92683
        • Research Site
      • Wildomar, California, Forenede Stater, 92595
        • Research Site
    • Colorado
      • Colorado Springs, Colorado, Forenede Stater, 80922
        • Research Site
      • Colorado Springs, Colorado, Forenede Stater, 80910
        • Research Site
      • Fort Collins, Colorado, Forenede Stater, 80525
        • Research Site
      • Lafayette, Colorado, Forenede Stater, 80026
        • Research Site
    • Florida
      • Boynton Beach, Florida, Forenede Stater, 33435
        • Research Site
      • Brandon, Florida, Forenede Stater, 33511
        • Research Site
      • Clearwater, Florida, Forenede Stater, 33765
        • Research Site
      • Clearwater, Florida, Forenede Stater, 33756
        • Research Site
      • Clermont, Florida, Forenede Stater, 34711
        • Research Site
      • Coral Gables, Florida, Forenede Stater, 33134
        • Research Site
      • Daytona Beach, Florida, Forenede Stater, 32117
        • Research Site
      • Fort Lauderdale, Florida, Forenede Stater, 33308
        • Research Site
      • Gainesville, Florida, Forenede Stater, 32607
        • Research Site
      • Hialeah, Florida, Forenede Stater, 33012
        • Research Site
      • Hialeah, Florida, Forenede Stater, 33029
        • Research Site
      • Hollywood, Florida, Forenede Stater, 33024
        • Research Site
      • Homestead, Florida, Forenede Stater, 33030
        • Research Site
      • Kissimmee, Florida, Forenede Stater, 34741
        • Research Site
      • Kissimmee, Florida, Forenede Stater, 34744
        • Research Site
      • Leesburg, Florida, Forenede Stater, 34748
        • Research Site
      • Loxahatchee Groves, Florida, Forenede Stater, 33470
        • Research Site
      • Miami, Florida, Forenede Stater, 33126
        • Research Site
      • Miami, Florida, Forenede Stater, 33186
        • Research Site
      • Miami, Florida, Forenede Stater, 33165
        • Research Site
      • Miami, Florida, Forenede Stater, 33175
        • Research Site
      • Miami, Florida, Forenede Stater, 33144
        • Research Site
      • Miami, Florida, Forenede Stater, 33125
        • Research Site
      • Miami, Florida, Forenede Stater, 33155
        • Research Site
      • Miami, Florida, Forenede Stater, 33174
        • Research Site
      • Miami, Florida, Forenede Stater, 33012
        • Research Site
      • Miami Lakes, Florida, Forenede Stater, 33014
        • Research Site
      • Ormond Beach, Florida, Forenede Stater, 32174
        • Research Site
      • Panama City, Florida, Forenede Stater, 32405
        • Research Site
      • Pembroke Pines, Florida, Forenede Stater, 33029
        • Research Site
      • Pensacola, Florida, Forenede Stater, 32503
        • Research Site
      • Port Charlotte, Florida, Forenede Stater, 33952
        • Research Site
      • Saint Petersburg, Florida, Forenede Stater, 33704
        • Research Site
      • Saint Petersburg, Florida, Forenede Stater, 33710
        • Research Site
      • Saint Petersburg, Florida, Forenede Stater, 33707
        • Research Site
      • Sarasota, Florida, Forenede Stater, 34239
        • Research Site
      • Tampa, Florida, Forenede Stater, 33603
        • Research Site
      • Tampa, Florida, Forenede Stater, 33607
        • Research Site
      • Winter Park, Florida, Forenede Stater, 32789
        • Research Site
    • Georgia
      • Atlanta, Georgia, Forenede Stater, 30328
        • Research Site
      • Atlanta, Georgia, Forenede Stater, 30308
        • Research Site
      • Atlanta, Georgia, Forenede Stater, 30345
        • Research Site
      • Atlanta, Georgia, Forenede Stater, 30331
        • Research Site
      • Blue Ridge, Georgia, Forenede Stater, 30513
        • Research Site
      • Columbus, Georgia, Forenede Stater, 31904
        • Research Site
      • Dacula, Georgia, Forenede Stater, 30019
        • Research Site
      • Duluth, Georgia, Forenede Stater, 30096
        • Research Site
      • Lawrenceville, Georgia, Forenede Stater, 30046
        • Research Site
      • Norcross, Georgia, Forenede Stater, 30071
        • Research Site
      • Rincon, Georgia, Forenede Stater, 31326
        • Research Site
      • Riverdale, Georgia, Forenede Stater, 30274
        • Research Site
      • Savannah, Georgia, Forenede Stater, 31406
        • Research Site
      • Woodstock, Georgia, Forenede Stater, 30189
        • Research Site
    • Illinois
      • Belleville, Illinois, Forenede Stater, 62220
        • Research Site
      • Champaign, Illinois, Forenede Stater, 61820
        • Research Site
      • Chicago, Illinois, Forenede Stater, 60607
        • Research Site
      • O'Fallon, Illinois, Forenede Stater, 62269
        • Research Site
      • Skokie, Illinois, Forenede Stater, 60076
        • Research Site
    • Indiana
      • Michigan City, Indiana, Forenede Stater, 46360
        • Research Site
      • Valparaiso, Indiana, Forenede Stater, 46383
        • Research Site
    • Iowa
      • Council Bluffs, Iowa, Forenede Stater, 51503
        • Research Site
      • West Des Moines, Iowa, Forenede Stater, 50266
        • Research Site
    • Kentucky
      • Fort Mitchell, Kentucky, Forenede Stater, 41017
        • Research Site
      • Owensboro, Kentucky, Forenede Stater, 42303
        • Research Site
      • Paducah, Kentucky, Forenede Stater, 42003
        • Research Site
    • Louisiana
      • Crowley, Louisiana, Forenede Stater, 70526
        • Research Site
      • Lafayette, Louisiana, Forenede Stater, 70508
        • Research Site
      • Lake Charles, Louisiana, Forenede Stater, 70601
        • Research Site
      • New Orleans, Louisiana, Forenede Stater, 70115
        • Research Site
      • Opelousas, Louisiana, Forenede Stater, 70570
        • Research Site
      • Sunset, Louisiana, Forenede Stater, 70584
        • Research Site
      • Zachary, Louisiana, Forenede Stater, 70791
        • Research Site
    • Maine
      • Bangor, Maine, Forenede Stater, 04401
        • Research Site
    • Maryland
      • Baltimore, Maryland, Forenede Stater, 21237
        • Research Site
      • Baltimore, Maryland, Forenede Stater, 21224
        • Research Site
      • Baltimore, Maryland, Forenede Stater, 21236
        • Research Site
      • Columbia, Maryland, Forenede Stater, 21044
        • Research Site
      • White Marsh, Maryland, Forenede Stater, 21162
        • Research Site
    • Massachusetts
      • Marlborough, Massachusetts, Forenede Stater, 01752
        • Research Site
      • Methuen, Massachusetts, Forenede Stater, 01844
        • Research Site
      • North Dartmouth, Massachusetts, Forenede Stater, 02747
        • Research Site
    • Michigan
      • Buckley, Michigan, Forenede Stater, 49620
        • Research Site
      • Cadillac, Michigan, Forenede Stater, 49601
        • Research Site
      • Canton, Michigan, Forenede Stater, 48187
        • Research Site
      • Caro, Michigan, Forenede Stater, 48723
        • Research Site
      • Farmington Hills, Michigan, Forenede Stater, 48336
        • Research Site
      • Flint, Michigan, Forenede Stater, 48504
        • Research Site
      • Port Huron, Michigan, Forenede Stater, 48060
        • Research Site
      • Rochester, Michigan, Forenede Stater, 48307
        • Research Site
      • Southfield, Michigan, Forenede Stater, 48034
        • Research Site
      • Troy, Michigan, Forenede Stater, 48085
        • Research Site
    • Minnesota
      • Edina, Minnesota, Forenede Stater, 55435
        • Research Site
      • Fridley, Minnesota, Forenede Stater, 55432
        • Research Site
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Research Site
      • Woodbury, Minnesota, Forenede Stater, 55125
        • Research Site
    • Mississippi
      • Biloxi, Mississippi, Forenede Stater, 39531
        • Research Site
    • Missouri
      • Belton, Missouri, Forenede Stater, 64012
        • Research Site
      • Chesterfield, Missouri, Forenede Stater, 63017
        • Research Site
      • Saint Charles, Missouri, Forenede Stater, 63301
        • Research Site
      • Saint Louis, Missouri, Forenede Stater, 63141
        • Research Site
      • Saint Louis, Missouri, Forenede Stater, 63143
        • Research Site
    • Montana
      • Billings, Montana, Forenede Stater, 59102
        • Research Site
    • Nebraska
      • Bellevue, Nebraska, Forenede Stater, 68005
        • Research Site
      • Bellevue, Nebraska, Forenede Stater, 68123
        • Research Site
    • Nevada
      • Las Vegas, Nevada, Forenede Stater, 89106
        • Research Site
      • Reno, Nevada, Forenede Stater, 89519
        • Research Site
    • New Hampshire
      • Portsmouth, New Hampshire, Forenede Stater, 03801
        • Research Site
    • New Jersey
      • Marlton, New Jersey, Forenede Stater, 08053
        • Research Site
      • Toms River, New Jersey, Forenede Stater, 08755
        • Research Site
    • New York
      • Bronx, New York, Forenede Stater, 10459
        • Research Site
      • Bronx, New York, Forenede Stater, 10457
        • Research Site
      • Bronx, New York, Forenede Stater, 10461
        • Research Site
      • Bronx, New York, Forenede Stater, 10455
        • Research Site
      • Bronx, New York, Forenede Stater, 10468
        • Research Site
      • Bronxville, New York, Forenede Stater, 10708
        • Research Site
      • Brooklyn, New York, Forenede Stater, 11229
        • Research Site
      • Jamaica, New York, Forenede Stater, 11435
        • Research Site
      • New Windsor, New York, Forenede Stater, 12553
        • Research Site
      • New York, New York, Forenede Stater, 10016
        • Research Site
    • North Carolina
      • Asheville, North Carolina, Forenede Stater, 28801
        • Research Site
      • Burlington, North Carolina, Forenede Stater, 27215
        • Research Site
      • Charlotte, North Carolina, Forenede Stater, 28277
        • Research Site
      • Charlotte, North Carolina, Forenede Stater, 28207
        • Research Site
      • Charlotte, North Carolina, Forenede Stater, 28210
        • Research Site
      • Elizabeth City, North Carolina, Forenede Stater, 27909
        • Research Site
      • Gastonia, North Carolina, Forenede Stater, 28054
        • Research Site
      • Greensboro, North Carolina, Forenede Stater, 27408
        • Research Site
      • Hendersonville, North Carolina, Forenede Stater, 28739
        • Research Site
      • Hickory, North Carolina, Forenede Stater, 28601
        • Research Site
      • Huntersville, North Carolina, Forenede Stater, 28078
        • Research Site
      • Lenoir, North Carolina, Forenede Stater, 28645
        • Research Site
      • Monroe, North Carolina, Forenede Stater, 28112
        • Research Site
      • Mooresville, North Carolina, Forenede Stater, 28117
        • Research Site
      • Morganton, North Carolina, Forenede Stater, 28655
        • Research Site
      • Mount Airy, North Carolina, Forenede Stater, 27030
        • Research Site
      • New Bern, North Carolina, Forenede Stater, 28562
        • Research Site
      • Raleigh, North Carolina, Forenede Stater, 27612
        • Research Site
      • Shelby, North Carolina, Forenede Stater, 28150
        • Research Site
      • Whiteville, North Carolina, Forenede Stater, 28472
        • Research Site
      • Wilmington, North Carolina, Forenede Stater, 28401
        • Research Site
      • Winston-Salem, North Carolina, Forenede Stater, 27103
        • Research Site
    • North Dakota
      • Fargo, North Dakota, Forenede Stater, 58104
        • Research Site
    • Ohio
      • Blue Ash, Ohio, Forenede Stater, 45242
        • Research Site
      • Cincinnati, Ohio, Forenede Stater, 45231
        • Research Site
      • Cincinnati, Ohio, Forenede Stater, 45245
        • Research Site
      • Columbus, Ohio, Forenede Stater, 43123
        • Research Site
      • Dayton, Ohio, Forenede Stater, 45459
        • Research Site
      • Dayton, Ohio, Forenede Stater, 45419
        • Research Site
      • Dublin, Ohio, Forenede Stater, 43016
        • Research Site
      • Kettering, Ohio, Forenede Stater, 45429
        • Research Site
      • Maumee, Ohio, Forenede Stater, 43537
        • Research Site
      • Toledo, Ohio, Forenede Stater, 43617
        • Research Site
    • Oklahoma
      • Edmond, Oklahoma, Forenede Stater, 73034
        • Research Site
      • Oklahoma City, Oklahoma, Forenede Stater, 73103
        • Research Site
      • Tulsa, Oklahoma, Forenede Stater, 74136
        • Research Site
    • Oregon
      • Medford, Oregon, Forenede Stater, 97504
        • Research Site
      • Portland, Oregon, Forenede Stater, 97202
        • Research Site
    • Pennsylvania
      • Altoona, Pennsylvania, Forenede Stater, 16602
        • Research Site
      • Erie, Pennsylvania, Forenede Stater, 16508
        • Research Site
      • Monroeville, Pennsylvania, Forenede Stater, 15665
        • Research Site
      • Philadelphia, Pennsylvania, Forenede Stater, 19114
        • Research Site
      • Phoenixville, Pennsylvania, Forenede Stater, 19460
        • Research Site
      • Pittsburgh, Pennsylvania, Forenede Stater, 15241
        • Research Site
      • Pittsburgh, Pennsylvania, Forenede Stater, 15243
        • Research Site
      • Pittsburgh, Pennsylvania, Forenede Stater, 15236
        • Research Site
      • Scottdale, Pennsylvania, Forenede Stater, 15683
        • Research Site
      • Uniontown, Pennsylvania, Forenede Stater, 15401
        • Research Site
    • Rhode Island
      • East Providence, Rhode Island, Forenede Stater, 02914
        • Research Site
      • Providence, Rhode Island, Forenede Stater, 02908
        • Research Site
    • South Carolina
      • Anderson, South Carolina, Forenede Stater, 29621
        • Research Site
      • Charleston, South Carolina, Forenede Stater, 29406
        • Research Site
      • Charleston, South Carolina, Forenede Stater, 29412
        • Research Site
      • Columbia, South Carolina, Forenede Stater, 29201
        • Research Site
      • Easley, South Carolina, Forenede Stater, 29640
        • Research Site
      • Gaffney, South Carolina, Forenede Stater, 29340
        • Research Site
      • Gaffney, South Carolina, Forenede Stater, 29341
        • Research Site
      • Greenville, South Carolina, Forenede Stater, 29615
        • Research Site
      • Greer, South Carolina, Forenede Stater, 29651
        • Research Site
      • Greer, South Carolina, Forenede Stater, 29650
        • Research Site
      • Hodges, South Carolina, Forenede Stater, 29653
        • Research Site
      • Indian Land, South Carolina, Forenede Stater, 29707
        • Research Site
      • Lancaster, South Carolina, Forenede Stater, 29720
        • Research Site
      • Mount Pleasant, South Carolina, Forenede Stater, 29464
        • Research Site
      • Rock Hill, South Carolina, Forenede Stater, 29732
        • Research Site
      • Seneca, South Carolina, Forenede Stater, 29678
        • Research Site
      • Spartanburg, South Carolina, Forenede Stater, 29303
        • Research Site
      • Spartanburg, South Carolina, Forenede Stater, 29301
        • Research Site
      • Union, South Carolina, Forenede Stater, 29379
        • Research Site
    • South Dakota
      • Rapid City, South Dakota, Forenede Stater, 57702
        • Research Site
    • Tennessee
      • Chattanooga, Tennessee, Forenede Stater, 37404
        • Research Site
      • Hendersonville, Tennessee, Forenede Stater, 37075
        • Research Site
      • Johnson City, Tennessee, Forenede Stater, 37601
        • Research Site
      • Knoxville, Tennessee, Forenede Stater, 37912
        • Research Site
    • Texas
      • Arlington, Texas, Forenede Stater, 76012
        • Research Site
      • Arlington, Texas, Forenede Stater, 76014
        • Research Site
      • Boerne, Texas, Forenede Stater, 78006
        • Research Site
      • Carrollton, Texas, Forenede Stater, 75007
        • Research Site
      • Corsicana, Texas, Forenede Stater, 75110
        • Research Site
      • Cypress, Texas, Forenede Stater, 77429
        • Research Site
      • Duncanville, Texas, Forenede Stater, 75116
        • Research Site
      • El Paso, Texas, Forenede Stater, 79903
        • Research Site
      • Fort Worth, Texas, Forenede Stater, 76109
        • Research Site
      • Fort Worth, Texas, Forenede Stater, 76104
        • Research Site
      • Houston, Texas, Forenede Stater, 77074
        • Research Site
      • Houston, Texas, Forenede Stater, 77058
        • Research Site
      • Houston, Texas, Forenede Stater, 77070
        • Research Site
      • Houston, Texas, Forenede Stater, 77084
        • Research Site
      • Houston, Texas, Forenede Stater, 77099
        • Research Site
      • Houston, Texas, Forenede Stater, 77079
        • Research Site
      • Houston, Texas, Forenede Stater, 77089
        • Research Site
      • Houston, Texas, Forenede Stater, 77008
        • Research Site
      • Houston, Texas, Forenede Stater, 77043
        • Research Site
      • Huntsville, Texas, Forenede Stater, 77340
        • Research Site
      • Katy, Texas, Forenede Stater, 77450
        • Research Site
      • Kerrville, Texas, Forenede Stater, 78028
        • Research Site
      • Killeen, Texas, Forenede Stater, 76543
        • Research Site
      • Kingwood, Texas, Forenede Stater, 77339
        • Research Site
      • Lampasas, Texas, Forenede Stater, 76550
        • Research Site
      • Lewisville, Texas, Forenede Stater, 75067
        • Research Site
      • Longview, Texas, Forenede Stater, 75605
        • Research Site
      • Lufkin, Texas, Forenede Stater, 75904
        • Research Site
      • McKinney, Texas, Forenede Stater, 75069
        • Research Site
      • McKinney, Texas, Forenede Stater, 75071
        • Research Site
      • Pearland, Texas, Forenede Stater, 77584
        • Research Site
      • Pflugerville, Texas, Forenede Stater, 78660
        • Research Site
      • Plano, Texas, Forenede Stater, 75093
        • Research Site
      • San Antonio, Texas, Forenede Stater, 78229
        • Research Site
      • San Antonio, Texas, Forenede Stater, 78258
        • Research Site
      • Sealy, Texas, Forenede Stater, 77474
        • Research Site
      • Sherman, Texas, Forenede Stater, 75092
        • Research Site
      • Splendora, Texas, Forenede Stater, 77372
        • Research Site
      • The Woodlands, Texas, Forenede Stater, 77380
        • Research Site
      • Webster, Texas, Forenede Stater, 77598
        • Research Site
    • Utah
      • Midvale, Utah, Forenede Stater, 84047
        • Research Site
      • Salt Lake City, Utah, Forenede Stater, 84102
        • Research Site
    • Virginia
      • Abingdon, Virginia, Forenede Stater, 24210
        • Research Site
      • Burke, Virginia, Forenede Stater, 22015
        • Research Site
      • Newport News, Virginia, Forenede Stater, 23606
        • Research Site
      • Richmond, Virginia, Forenede Stater, 23225
        • Research Site
      • Richmond, Virginia, Forenede Stater, 23220
        • Research Site
      • Richmond, Virginia, Forenede Stater, 23235
        • Research Site
      • Richmond, Virginia, Forenede Stater, 23230
        • Research Site
      • Richmond, Virginia, Forenede Stater, 23219
        • Research Site
      • Richmond, Virginia, Forenede Stater, 23114
        • Research Site
      • Virginia Beach, Virginia, Forenede Stater, 23454
        • Research Site
      • Williamsburg, Virginia, Forenede Stater, 23188
        • Research Site
    • Washington
      • Bellevue, Washington, Forenede Stater, 98007
        • Research Site
      • Richland, Washington, Forenede Stater, 99352
        • Research Site
      • Spokane, Washington, Forenede Stater, 99202
        • Research Site
      • Spokane, Washington, Forenede Stater, 99216
        • Research Site
      • Tacoma, Washington, Forenede Stater, 98405
        • Research Site
    • West Virginia
      • Morgantown, West Virginia, Forenede Stater, 26505
        • Research Site
    • Wisconsin
      • Greenfield, Wisconsin, Forenede Stater, 53228
        • Research Site
  • Frankrig
      • Lyon Cedex 4, Frankrig, 69317
        • Research Site
      • Marseille, Frankrig, 13003
        • Research Site
      • Nantes, Frankrig, 44277
        • Research Site
      • Nimes Cedex 09, Frankrig, 30029
        • Research Site
      • Vandoeuvre les Nancy, Frankrig, 54500
        • Research Site
  • Holland
      • Almelo, Holland, 7609 PP
        • Research Site
      • Almere, Holland, 1311 RL
        • Research Site
      • Almere, Holland, 3562KX
        • Research Site
      • Beek, Holland, 6191 JW
        • Research Site
      • Breda, Holland, 4818 CK
        • Research Site
      • Capelle aan den IJssel, Holland, 2906 ZC
        • Research Site
      • Eindhoven, Holland, 5623EJ
        • Research Site
      • Enschede, Holland, 7512 KZ
        • Research Site
      • Harderwijk, Holland, 3844 DG
        • Research Site
      • Heerlen, Holland, 6419 PC
        • Research Site
      • Hoorn NH, Holland, 1624 NP
        • Research Site
      • Voerendaal, Holland, 6367
        • Research Site
      • Zutphen, Holland, 7207 AE
        • Research Site
      • Zwolle, Holland, 8025 AB
        • Research Site
  • Italien
      • Bologna, Italien, 40138
        • Research Site
      • Foggia, Italien, 71100
        • Research Site
      • Genova, Italien, 16132
        • Research Site
      • Messina, Italien, 98125
        • Research Site
      • Milan, Italien, 20122
        • Research Site
      • Modena, Italien, 41124
        • Research Site
      • Napoli, Italien, 80131
        • Research Site
      • Palermo, Italien, 90127
        • Research Site
      • Parma, Italien, 43100
        • Research Site
      • Pisa, Italien, 56124
        • Research Site
      • Pordenone, Italien, 33170
        • Research Site
      • Roma, Italien, 00128
        • Research Site
      • Roma, Italien, 00133
        • Research Site
      • Roma, Italien, 00185
        • Research Site
      • Tradate, Italien, 21049
        • Research Site
  • Japan
      • Osakasayama-shi, Japan, 589-8511
        • Research Site
      • Sakaide-shi, Japan, 762-8550
        • Research Site
      • Seto-shi, Japan, 489-8642
        • Research Site
      • Shinagawa-ku, Japan, 142-8666
        • Research Site
      • Yanagawa-shi, Japan, 832-0059
        • Research Site
  • Kina
      • Baotou, Kina, 14010
        • Research Site
      • Beijing, Kina, 100020
        • Research Site
      • Beijing, Kina, 100034
        • Research Site
      • Beijing, Kina, 100050
        • Research Site
      • Beijing, Kina, CN-100029
        • Research Site
      • Changsha, Kina, 410004
        • Research Site
      • Changsha, Kina, 410005
        • Research Site
      • Changsha, Kina, 410078
        • Research Site
      • Chengdu, Kina, 610041
        • Research Site
      • Guangzhou, Kina, 510150
        • Research Site
      • Guangzhou, Kina, 510080
        • Research Site
      • Guangzhou, Kina, 510220
        • Research Site
      • Guiyang, Kina, 550004
        • Research Site
      • Haikou, Kina, 570208
        • Research Site
      • Hangzhou, Kina, 310006
        • Research Site
      • Hangzhou, Kina, 310003
        • Research Site
      • Hohhot, Kina, 010017
        • Research Site
      • Hohhot, Kina, 610078
        • Research Site
      • Huhehaote, Kina, 010050
        • Research Site
      • Lanzhou, Kina, 730000
        • Research Site
      • Linhai, Kina, 317000
        • Research Site
      • Nanchang, Kina, 330006
        • Research Site
      • Nanjing, Kina, 210006
        • Research Site
      • Nanjing, Kina, CN-210000
        • Research Site
      • Nanjing, Kina, 210000
        • Research Site
      • Pingxiang, Kina, 337055
        • Research Site
      • Shanghai, Kina, 201199
        • Research Site
      • Shanghai, Kina, 200135
        • Research Site
      • Shenyang, Kina, 110001
        • Research Site
      • Shenzhen, Kina, 518020
        • Research Site
      • Shenzhen, Kina, 518029
        • Research Site
      • Shijiazhuang, Kina, 050051
        • Research Site
      • Shijiazhuang, Kina, 50051
        • Research Site
      • Wuhan, Kina, 430033
        • Research Site
      • Xi'an, Kina, 710004
        • Research Site
      • Xiangtan, Kina, 411100
        • Research Site
      • Xuzhou, Kina, 221006
        • Research Site
      • Yanji, Kina, 133000
        • Research Site
      • Zhanjiang, Kina, 524001
        • Research Site
  • Mexico
      • Cuautitlan Izcalli, Mexico, 54769
        • Research Site
      • Guadalajara, Mexico, 44670
        • Research Site
      • Guadalajara, Mexico, 44100
        • Research Site
      • Mexico, Mexico, 14050
        • Research Site
      • Monterrey, Mexico, 64060
        • Research Site
      • Monterrey, Mexico, 64718
        • Research Site
  • New Zealand
      • Auckland, New Zealand, 0626
        • Research Site
      • Christchurch, New Zealand, 8024
        • Research Site
      • Christchurch, New Zealand, 8140
        • Research Site
      • Dunedin, New Zealand, 9016
        • Research Site
      • Greenlane, New Zealand, 1051
        • Research Site
      • Greenlane East, New Zealand, 1051
        • Research Site
      • Hamilton, New Zealand, 3240
        • Research Site
      • Havelock North, New Zealand, 4130
        • Research Site
      • Newtown, New Zealand, 6242
        • Research Site
      • Papatoetoe, New Zealand, 2025
        • Research Site
      • Tauranga, New Zealand, 3143
        • Research Site
  • Peru
      • Cusco, Peru
        • Research Site
      • Lima, Peru, 15033
        • Research Site
      • Lima, Peru, LIMA 27
        • Research Site
      • Lima, Peru, LIMA 41
        • Research Site
      • Lima, Peru, Lima 18
        • Research Site
      • Lima, Peru, Lima 32
        • Research Site
      • Lima, Peru, 15102
        • Research Site
      • Lima, Peru, LIMA 21
        • Research Site
      • Lima, Peru, L 41
        • Research Site
      • Lima, Peru, Lima-33
        • Research Site
      • Miraflores, Peru, 15046
        • Research Site
      • Piura, Peru, 51
        • Research Site
      • Santa Beatriz, Peru, LIMA 14
        • Research Site
  • Polen
      • Białystok, Polen, 15-003
        • Research Site
      • Białystok, Polen, 15-044
        • Research Site
      • Bydgoszcz, Polen, 85-863
        • Research Site
      • Poznań, Polen, 60-823
        • Research Site
      • Ruda Śląska, Polen, 41-707
        • Research Site
      • Rzeszow, Polen, 35-301
        • Research Site
      • Rzeszów, Polen, 35-205
        • Research Site
      • Skarżysko-Kamienna, Polen, 26-110
        • Research Site
      • Szczecin, Polen, 70-111
        • Research Site
      • Tarnów, Polen, 33-100
        • Research Site
      • Warszawa, Polen, 01-518
        • Research Site
      • Wrocław, Polen, 54-239
        • Research Site
      • Zabrze, Polen, 41-807
        • Research Site
  • Serbien
      • Belgrade, Serbien, 11000
        • Research Site
      • Belgrade, Serbien, 11070
        • Research Site
      • Kragujevac, Serbien, 34000
        • Research Site
      • Nis, Serbien, 18000
        • Research Site
      • Sremska Kamenica, Serbien, 21204
        • Research Site
      • Valjevo, Serbien, 14000
        • Research Site
  • Spanien
      • Alcobendas, Spanien, 28100
        • Research Site
      • Alicante, Spanien, 03004
        • Research Site
      • Alzira, Spanien, 46410
        • Research Site
      • Badalona(Barcelona), Spanien, 08916
        • Research Site
      • Barcelona, Spanien, 08028
        • Research Site
      • Barcelona, Spanien, 08041
        • Research Site
      • Barcelona, Spanien, 08003
        • Research Site
      • Barcelona, Spanien, 08006
        • Research Site
      • Barcelona, Spanien, 08023
        • Research Site
      • Barcelona, Spanien, 08550
        • Research Site
      • Cartagena, Spanien, 30202
        • Research Site
      • Coruna, Spanien, 15011A
        • Research Site
      • Girona, Spanien, 17005
        • Research Site
      • Laredo, Spanien, 39770
        • Research Site
      • Lleida, Spanien, 25198
        • Research Site
      • Madrid, Spanien, 28040
        • Research Site
      • Madrid, Spanien, 28007
        • Research Site
      • Malaga, Spanien, 29010
        • Research Site
      • Marbella (Málaga), Spanien, 29603
        • Research Site
      • Mataro, Spanien, 08303
        • Research Site
      • Mérida (Badajoz), Spanien, 06800
        • Research Site
      • Pamplona, Spanien, 31008
        • Research Site
      • Peralada, Spanien, 17491
        • Research Site
      • Ponferrada, Spanien, 24411
        • Research Site
      • Sabadell, Spanien, 08208
        • Research Site
      • Salamanca, Spanien, 37007
        • Research Site
      • Sant Boi de Llobregat, Spanien, 08830
        • Research Site
      • Valencia, Spanien, 46015
        • Research Site
      • Zaragoza, Spanien, 50009
        • Research Site
  • Sverige
      • Helsingborg, Sverige, 25220
        • Research Site
      • Karlskrona, Sverige, 37171
        • Research Site
      • Lund, Sverige, 22222
        • Research Site
      • Malmo, Sverige, 21152
        • Research Site
      • Stockholm, Sverige, SE-181 58
        • Research Site
      • Stockholm, Sverige, 114 46
        • Research Site
  • Sydafrika
      • Benoni, Sydafrika, 1500
        • Research Site
      • Bloemfontein, Sydafrika, 9301
        • Research Site
      • Boksburg, Sydafrika, 1459
        • Research Site
      • Boksburg, Sydafrika, 1460
        • Research Site
      • Cape Town, Sydafrika, 7700
        • Research Site
      • Cape Town, Sydafrika, 7764
        • Research Site
      • Cape Town, Sydafrika, 7570
        • Research Site
      • Cape Town, Sydafrika, 7500
        • Research Site
      • Cape Town, Sydafrika, 7550
        • Research Site
      • Cape Town, Sydafrika, 08000
        • Research Site
      • Cape Town, Sydafrika, 7780
        • Research Site
      • Durban, Sydafrika, 4001
        • Research Site
      • Durban, Sydafrika, 4071
        • Research Site
      • Johannesburg, Sydafrika, 1724
        • Research Site
      • Johannesburg, Sydafrika, 2188
        • Research Site
      • Port Elizabeth, Sydafrika, 6014
        • Research Site
      • Pretoria, Sydafrika, 0002
        • Research Site
      • Pretoria, Sydafrika, 0183
        • Research Site
      • Pretoria, Sydafrika, 0014
        • Research Site
      • Umhlanga, Sydafrika, 4319
        • Research Site
  • Taiwan
      • Kaohsiung, Taiwan, 83301
        • Research Site
      • Kaohsiung, Taiwan, 00807
        • Research Site
      • Kaohsiung City, Taiwan, 82445
        • Research Site
      • Keelung City, Taiwan, 20401
        • Research Site
      • New-Taipei, Taiwan, 22056
        • Research Site
      • Taichung, Taiwan, 40447
        • Research Site
      • Taichung, Taiwan, 00407
        • Research Site
      • Taipei, Taiwan, 10002
        • Research Site
      • Taoyuan, Taiwan, 00333
        • Research Site
  • Tjekkiet
      • Benešov, Tjekkiet, 256 01
        • Research Site
      • Beroun, Tjekkiet, 26601
        • Research Site
      • Jindrichuv Hradec, Tjekkiet, 37701
        • Research Site
      • Liberec, Tjekkiet, 525947
        • Research Site
      • Liberec 1, Tjekkiet, 46063
        • Research Site
      • Melnik, Tjekkiet, 250 63
        • Research Site
      • Moravsky Krumlov, Tjekkiet, 67201
        • Research Site
      • Praha 1, Tjekkiet, 110 00
        • Research Site
      • Praha 10, Tjekkiet, 10800
        • Research Site
      • Teplice, Tjekkiet, 415 01
        • Research Site
      • Zatec, Tjekkiet, 43801
        • Research Site
  • Tyskland
      • Aschaffenburg, Tyskland, 63739
        • Research Site
      • Augsburg, Tyskland, 86150
        • Research Site
      • Bad Wörishofen, Tyskland, 86825
        • Research Site
      • Bamberg, Tyskland, 96049
        • Research Site
      • Bergisch Gladbach, Tyskland, 51429
        • Research Site
      • Berlin, Tyskland, 14059
        • Research Site
      • Berlin, Tyskland, 10117
        • Research Site
      • Berlin, Tyskland, 10367
        • Research Site
      • Berlin, Tyskland, 10717
        • Research Site
      • Berlin, Tyskland, 10969
        • Research Site
      • Berlin, Tyskland, 10119
        • Research Site
      • Berlin, Tyskland, 10787
        • Research Site
      • Berlin, Tyskland, 12157
        • Research Site
      • Berlin, Tyskland, 12203
        • Research Site
      • Berlin, Tyskland, 13187
        • Research Site
      • Berlin, Tyskland, 12159
        • Research Site
      • Bonn, Tyskland, 53123
        • Research Site
      • Bonn, Tyskland, 53119
        • Research Site
      • Cottbus, Tyskland, 03044
        • Research Site
      • Darmstadt, Tyskland, 64283
        • Research Site
      • Deggendorf, Tyskland, 94469
        • Research Site
      • Deggingen, Tyskland, 73326
        • Research Site
      • Dortmund, Tyskland, 44263
        • Research Site
      • Düren, Tyskland, 52349
        • Research Site
      • Erlangen, Tyskland, 91052
        • Research Site
      • Essen, Tyskland, 45355
        • Research Site
      • Essen, Tyskland, 45359
        • Research Site
      • Frankfurt, Tyskland, 60596
        • Research Site
      • Frankfurt am Main, Tyskland, 60596
        • Research Site
      • Frankfurt am Main, Tyskland, 60389
        • Research Site
      • Gelsenkirchen, Tyskland, 45879
        • Research Site
      • Grosshansdof, Tyskland, 22927
        • Research Site
      • Halle, Tyskland, 06108
        • Research Site
      • Hamburg, Tyskland, 20354
        • Research Site
      • Hamburg, Tyskland, 22299
        • Research Site
      • Hannover, Tyskland, 30625
        • Research Site
      • Hannover, Tyskland, D-30173
        • Research Site
      • Hannover, Tyskland, 30167
        • Research Site
      • Ibbenbüren, Tyskland, 49477
        • Research Site
      • Kiel, Tyskland, 24105
        • Research Site
      • Koblenz, Tyskland, 56068
        • Research Site
      • Köln, Tyskland, 51069
        • Research Site
      • Landsberg, Tyskland, 86899
        • Research Site
      • Leipzig, Tyskland, 04357
        • Research Site
      • Leipzig, Tyskland, 04103
        • Research Site
      • Leipzig, Tyskland, 04207
        • Research Site
      • Leipzig, Tyskland, 04275
        • Research Site
      • Leipzig, Tyskland, 04107
        • Research Site
      • Leipzig, Tyskland, 04157
        • Research Site
      • Lübeck, Tyskland, 23552
        • Research Site
      • Magdeburg, Tyskland, 39120
        • Research Site
      • Mainz, Tyskland, 55131
        • Research Site
      • Marburg, Tyskland, 35037
        • Research Site
      • München, Tyskland, 80339
        • Research Site
      • München, Tyskland, 80539
        • Research Site
      • Münster, Tyskland, 48145
        • Research Site
      • Neu-Isenburg, Tyskland, 63263
        • Research Site
      • Peine, Tyskland, 31224
        • Research Site
      • Potsdam, Tyskland, 14469
        • Research Site
      • Radebeul, Tyskland, 01445
        • Research Site
      • Rosenheim, Tyskland, 83022
        • Research Site
      • Ruesselsheim, Tyskland, D-65428
        • Research Site
      • Rüdersdorf, Tyskland, 15562
        • Research Site
      • Schleswig, Tyskland, 24837
        • Research Site
      • Schwedt, Tyskland, 16303
        • Research Site
      • Wardenburg, Tyskland, 26203
        • Research Site
      • Weinheim, Tyskland, 69469
        • Research Site
      • Wiesbaden, Tyskland, 65189
        • Research Site
      • Wiesloch, Tyskland, 69168
        • Research Site
      • Witten, Tyskland, 58452
        • Research Site
      • Zerbst, Tyskland, 39261
        • Research Site
  • Ungarn
      • Balassagyarmat, Ungarn, 2660
        • Research Site
      • Budapest, Ungarn, 1134
        • Research Site
      • Csorna, Ungarn, 9300
        • Research Site
      • Debrecen, Ungarn, H-4031
        • Research Site
      • Gödöllő, Ungarn, 2100
        • Research Site
      • Kaposvár, Ungarn, H-7400
        • Research Site
      • Kapuvar, Ungarn, 09330
        • Research Site
      • Komarom, Ungarn, 2900
        • Research Site
      • Komló, Ungarn, 7300
        • Research Site
      • Miskolc, Ungarn, 3529
        • Research Site
      • Nyíregyháza, Ungarn, 4400
        • Research Site
      • Siófok, Ungarn, 08600
        • Research Site
      • Szigetszentmiklós, Ungarn, 2310
        • Research Site
      • Százhalombatta, Ungarn, 2440
        • Research Site
      • Törökbálint, Ungarn, 2045
        • Research Site
  • Østrig
      • Feldbach, Østrig, A-8330
        • Research Site
      • Grieskirchen, Østrig, 4710
        • Research Site
      • Hallein, Østrig, 5400
        • Research Site
      • Linz, Østrig, 04020
        • Research Site
      • Salzburg, Østrig, 5020
        • Research Site
      • Thalheim, Østrig, 4600
        • Research Site
      • Vienna, Østrig, 1190
        • Research Site
      • Wels, Østrig, 4600
        • Research Site

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

40 år til 80 år (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inklusionskriterier

  • Ikke-fertilitetspotentiale (dvs. fysiologisk ude af stand til at blive gravid, inklusive enhver kvinde, der er 2 år efter overgangsalderen); eller i den fødedygtige alder, har en negativ serumgraviditetstest ved besøg 1 og accepterer acceptable præventionsmetoder, der anvendes konsekvent og korrekt i hele undersøgelsens varighed.
  • Forsøgspersoner med en etableret klinisk historie med KOL som defineret af American Thoracic Society (ATS)/European Respiratory Society (ERS),
  • Nuværende eller tidligere rygere med en historie på mindst 10 pakkeår med cigaretrygning.
  • Forceret ekspiratorisk volumen på 1 sekund (FEV1)/Forced vital kapacitet (FVC)-forhold skal være <0,70, og FEV1 skal være <65 % af den forventede normalværdi beregnet ved hjælp af NHANES III-referenceligninger (eller referencenormer, der gælder for andre regioner).
  • Emner med historie med eksacerbationer.

Se venligst undersøgelsesprotokollen for den komplette liste over inklusionskriterier.

Eksklusionskriterier

  • Væsentlige sygdomme eller tilstande ud over KOL, som efter Investigators vurdering kan bringe forsøgspersonen i fare på grund af deltagelse i undersøgelsen eller kan påvirke enten undersøgelsens resultater eller forsøgspersonens mulighed for at deltage i undersøgelsen.
  • Kvinder, der er gravide eller ammer, eller planlægger at blive gravide i løbet af undersøgelsen, eller kvinder i den fødedygtige alder, som ikke bruger en acceptabel præventionsmetode.
  • Forsøgspersoner, som efter efterforskerens opfattelse har en aktuel diagnose astma.
  • Forsøgspersoner, der har været indlagt på grund af dårligt kontrolleret KOL inden for 3 måneder før besøg 1 (screening)
  • Forsøgspersoner, der har dårligt kontrolleret KOL, defineret som akut forværring af KOL, der kræver behandling med orale kortikosteroider eller antibiotika inden for 6 uger før besøg 1 (screening)
  • Immunsuppression eller alvorlige neurologiske lidelser, der påvirker kontrollen af ​​de øvre luftveje eller andre risikofaktorer, som efter investigatorens mening ville sætte forsøgspersonen i betydelig risiko for lungebetændelse.
  • Forsøgspersoner med diagnosen snævervinklet glaukom, som efter undersøgerens vurdering ikke er blevet tilstrækkeligt behandlet.
  • Personer, der har en historie med overfølsomhed over for β2-agonister, budesonid eller andre kortikosteroidkomponenter, glycopyrronium eller andre muskarine antikolinergika eller enhver anden komponent i IMP'erne.

Se venligst undersøgelsesprotokollen for den komplette liste over inklusionskriterier.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Firedobbelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: BGF (PT010) MDI 320/14,4/9,6 μg
BGF MDI 320/14,4/9,6 μg, Budesonid, Glycopyrronium, Formoterol Fumarate Aerosol (PT010, BGF afmålt dosis inhalator [MDI])
Medicin: BGF MDI 320/14,4/9,6 μg
Budensonid, Glycopyrronium og Formoterol Fumarate
Andre navne:
  • BGF
Eksperimentel: BGF (PT010) MDI 160/14,4/9,6 μg
BGF MDI 160/14,4/9,6 μg, Budesonid, Glycopyrronium, Formoterol Fumarate Aerosol (PT010, BGF afmålt dosis inhalator [MDI])
Medicin: BGF MDI 160/14,4/9,6 μg
Budensonid, Glycopyrronium og Formoterol Fumarate
Andre navne:
  • BGF
Eksperimentel: BFF (PT009) MDI 320/9,6 μg
BFF MDI 320/9,6 μg Budesonid, Formoterol Fumarate Aerosol Glycopyrronium og Formoterol Fumarate Inhalation Aerosol (PT009)
Medicin: BFF MDI 320/9,6 μg
Budensonid og formoterolfumarat
Andre navne:
  • BFF
Eksperimentel: GFF (PT003) MDI 14,4/9,6 μg
GFF MDI 14,4/9,6 μg Glycopyrronium, Formoterol Fumarate Aerosol Budesonide og Formoterol Fumarate Inhalation Aerosol (PT003)
Medicin: GFF MDI 14,4/9,6 μg
Glycopyrronium og formoterolfumarat
Andre navne:
  • GFF

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Justeret forekomst af moderate eller svære eksacerbationer
Tidsramme: 52 ugers behandlingsperiode
Justeret forekomst af moderate eller svære eksacerbationer
52 ugers behandlingsperiode

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Tid til første moderat eller svær KOL-eksacerbation
Tidsramme: 52 uger
Tid til den første moderate eller svære KOL-eksacerbation (andel med hændelsen rapporteret som mediantid blev ikke nået, statistiske analyser er baseret på tid til hændelse)
52 uger
Ændring fra baseline i gennemsnitlig daglig brug af Ventolin HFA over 24 uger
Tidsramme: 24 uger
Ændring fra baseline i den gennemsnitlige daglige brug af Ventolin HFA i løbet af 24 uger
24 uger
Procentdel af forsøgspersoner, der opnår et MCID på 4 enheder eller mere i SGRQ Total Score
Tidsramme: i uge 24
Procentdel af forsøgspersoner, der opnår en minimal klinisk vigtig forskel (MCID) på 4 enheder eller mere i SGRQ (St. George's Respiratory Questionnaire) samlet score i uge 24
i uge 24
Tid til døden (alle årsager)
Tidsramme: 52 uger
Emnedødsfald (alle årsager)
52 uger
Hyppighed af alvorlige KOL-eksacerbationer
Tidsramme: 52 uger
Hyppighed af alvorlige KOL-eksacerbationer
52 uger

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Pearl Therapeutics, Inc.

Efterforskere

  • Studieleder: Paul M Dorinsky, MD, Pearl Therapeutics

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

30. juni 2015

Primær færdiggørelse (Faktiske)

26. juli 2019

Studieafslutning (Faktiske)

26. juli 2019

Datoer for studieregistrering

Først indsendt

29. maj 2015

Først indsendt, der opfyldte QC-kriterier

5. juni 2015

Først opslået (Skøn)

8. juni 2015

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

2. februar 2021

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

1. februar 2021

Sidst verificeret

1. januar 2021

Mere information

Begreber relateret til denne undersøgelse

Andre undersøgelses-id-numre

  • PT010005

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ja

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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