S1505: Kombinationskemoterapi eller gemcitabinhydrochlorid og paclitaxel albuminstabiliseret nanopartikelformulering før kirurgi til behandling af patienter med kræft i bugspytkirtlen, der kan fjernes ved kirurgi
18. oktober 2022 opdateret af: Southwest Oncology Group
Et randomiseret fase II-studie af perioperativ mFOLFIRINOX versus Gemcitabin/Nab-Paclitaxel som terapi for resektabelt pancreasadenokarcinom
Dette randomiserede fase II-forsøg undersøger, hvor godt fluorouracil, irinotecanhydrochlorid og oxaliplatin (kombinationskemoterapi) virker og sammenlignes med gemcitabinhydrochlorid og paclitaxel albuminstabiliseret nanopartikelformulering før operation til behandling af patienter med bugspytkirtelkræft, som kan fjernes ved kirurgi.
Lægemidler, der bruges i kemoterapi, såsom fluorouracil, irinotecanhydrochlorid, oxaliplatin, gemcitabinhydrochlorid og paclitaxel albuminstabiliseret nanopartikelformulering, virker på forskellige måder for at stoppe væksten af tumorceller, enten ved at dræbe cellerne, ved at forhindre dem i at dele sig, eller ved at forhindre dem i at sprede sig.
At give mere end ét lægemiddel (kombinationskemoterapi) kan dræbe flere tumorceller.
Det vides endnu ikke, om kombinationskemoterapi er mere effektiv end gemcitabinhydrochlorid og paclitaxel albuminstabiliseret nanopartikelformulering før operation til behandling af bugspytkirtelkræft.
Studieoversigt
Status
Afsluttet
Detaljeret beskrivelse
PRIMÆRE MÅL:
I. At vurdere 2-års samlet overlevelse i hver behandlingsarm (fluorouracil, irinotecan hydrochlorid og oxaliplatin [modificeret (m)FOLFIRINOX] og gemcitabin [gemcitabin hydrochlorid]/nab-paclitaxel [paclitaxel albumin-stabiliseret nanopartikelformulering]) hos patienter med resecerbar bugspytkirtelkræft.
II. Hvis den angivne tærskel er opfyldt i en eller begge arme: at vælge det bedre regime med hensyn til 2-års samlet overlevelse.
SEKUNDÆRE MÅL:
I. At estimere, for alle patienter og inden for behandlingsarme: hyppighed og sværhedsgrad af uønskede hændelser forbundet med kemoterapi i det perioperative miljø.
II. For at estimere, for alle patienter og inden for behandlingsarme: andel af patienter, der skal til operation til resektion efter præoperativ kemoterapi.
III. For at estimere, for alle patienter og inden for behandlingsarme: andel af patienter, der opnår makroskopisk fuldstændig tumorfjernelse med negative mikroskopiske kirurgiske marginer (R0) resektion efter præoperativ kemoterapi.
IV. At estimere, for alle patienter og inden for behandlingsarme: samlet responsrate efter præoperativ kemoterapi, inklusive bekræftet og ubekræftet, fuldstændig og delvis respons, pr. responsevalueringskriterier i solide tumorer (RECIST) 1.1.
V. At estimere, for alle patienter og inden for behandlingsarme: patologiske responsrater efter R0 eller makroskopisk fuldstændig tumorfjernelse med enhver positiv mikroskopisk kirurgisk margin (R1) resektion.
VI. For at estimere, for alle patienter og inden for behandlingsarme: mønstre af tilbagefald (loko-regionalt, fjernt) efter R0 eller R1 resektion.
VII. For at estimere, for alle patienter og inden for behandlingsarme: sygdomsfri overlevelse fra tidspunktet for R0 eller R1 resektion.
OVERSIGT: Patienterne randomiseres til 1 ud af 2 behandlingsarme.
ARM I: Patienterne får oxaliplatin intravenøst (IV) over 2 timer og irinotecanhydrochlorid IV over 90 minutter på dag 1 og 15. Patienterne får også fluorouracil IV over 46 timer på dag 1-3 og 15-17. Behandlingen gentages hver 28. dag i 3 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter, der opnår stabil sygdom eller bedre, gennemgår pancreatektomi 4-8 uger efter afslutning af de første 3 behandlingsforløb. Inden for 4-8 uger efter pancreatektomi får patienterne yderligere 3 behandlinger med oxaliplatin, irinotecanhydrochlorid og fluorouracil i fravær af sygdomsprogression eller uacceptabel toksicitet.
ARM II: Patienter modtager paclitaxel albumin-stabiliseret nanopartikelformulering IV over 30 minutter og gemcitabinhydrochlorid IV over 30 minutter på dag 1, 8 og 15. Behandlingen gentages hver 28. dag i 3 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter, der opnår stabil sygdom eller bedre, gennemgår pancreatektomi 4-8 uger efter afslutning af de første 3 behandlingsforløb. Inden for 4-8 uger efter pancreatektomi får patienterne yderligere 3 forløb med paclitaxel albumin-stabiliseret nanopartikelformulering og gemcitabinhydrochloridbehandling i fravær af sygdomsprogression eller uacceptabel toksicitet.
Efter afsluttet undersøgelsesbehandling følges patienterne hver 3. måned i 2 år og derefter hver 6. måned i 2 år.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
147
Fase
- Fase 2
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Alabama
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Birmingham, Alabama, Forenede Stater, 35233
- University of Alabama at Birmingham Cancer Center
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Mobile, Alabama, Forenede Stater, 36688
- University of South Alabama Mitchell Cancer Institute
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Alaska
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Anchorage, Alaska, Forenede Stater, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, Forenede Stater, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, Forenede Stater, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Forenede Stater, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, Forenede Stater, 99504
- Anchorage Radiation Therapy Center
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Regional Hospital
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Arizona
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Phoenix, Arizona, Forenede Stater, 85004
- University of Arizona Cancer Center at Saint Joseph's
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Tucson, Arizona, Forenede Stater, 85704
- University of Arizona Cancer Center-Orange Grove Campus
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Tucson, Arizona, Forenede Stater, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, Forenede Stater, 85719
- University of Arizona Cancer Center-North Campus
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Arkansas
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Hot Springs, Arkansas, Forenede Stater, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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Jonesboro, Arkansas, Forenede Stater, 72401
- Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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California
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Anaheim, California, Forenede Stater, 92806
- Kaiser Permanente-Anaheim
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Antioch, California, Forenede Stater, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Auburn, California, Forenede Stater, 95602
- Sutter Auburn Faith Hospital
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Auburn, California, Forenede Stater, 95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
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Baldwin Park, California, Forenede Stater, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, Forenede Stater, 90706
- Kaiser Permanente-Bellflower
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Berkeley, California, Forenede Stater, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burbank, California, Forenede Stater, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Burlingame, California, Forenede Stater, 94010
- Mills-Peninsula Medical Center
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Cameron Park, California, Forenede Stater, 95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
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Castro Valley, California, Forenede Stater, 94546
- Eden Hospital Medical Center
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Davis, California, Forenede Stater, 95616
- Sutter Davis Hospital
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Dublin, California, Forenede Stater, 94568
- Epic Care-Dublin
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Emeryville, California, Forenede Stater, 94608
- Bay Area Breast Surgeons Inc
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Emeryville, California, Forenede Stater, 94608
- Epic Care Partners in Cancer Care
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Fontana, California, Forenede Stater, 92335
- Kaiser Permanente-Fontana
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Fremont, California, Forenede Stater, 94538
- Kaiser Permanente-Fremont
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Fremont, California, Forenede Stater, 94538
- Palo Alto Medical Foundation-Fremont
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Fresno, California, Forenede Stater, 93720
- Kaiser Permanente-Fresno
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Harbor City, California, Forenede Stater, 90710
- Kaiser Permanente - Harbor City
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Irvine, California, Forenede Stater, 92618
- Kaiser Permanente-Irvine
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La Jolla, California, Forenede Stater, 92093
- UC San Diego Moores Cancer Center
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Los Angeles, California, Forenede Stater, 90033
- USC / Norris Comprehensive Cancer Center
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Los Angeles, California, Forenede Stater, 90033
- Los Angeles County-USC Medical Center
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Los Angeles, California, Forenede Stater, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, Forenede Stater, 90034
- Kaiser Permanente-Cadillac
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Martinez, California, Forenede Stater, 94553-3156
- Contra Costa Regional Medical Center
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Modesto, California, Forenede Stater, 95355
- Memorial Medical Center
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Modesto, California, Forenede Stater, 95356
- Kaiser Permanente-Modesto
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Mountain View, California, Forenede Stater, 94040
- Palo Alto Medical Foundation-Camino Division
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Mountain View, California, Forenede Stater, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Newport Beach, California, Forenede Stater, 92663
- USC Norris Oncology/Hematology-Newport Beach
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Novato, California, Forenede Stater, 94945
- Sutter Cancer Research Consortium
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Oakland, California, Forenede Stater, 94611
- Kaiser Permanente-Oakland
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Oakland, California, Forenede Stater, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, Forenede Stater, 94609
- Bay Area Tumor Institute
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Orange, California, Forenede Stater, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
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Orange, California, Forenede Stater, 92868
- Saint Joseph Hospital - Orange
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Palo Alto, California, Forenede Stater, 94301
- Palo Alto Medical Foundation Health Care
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Panorama City, California, Forenede Stater, 91402
- Kaiser Permanente - Panorama City
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Pasadena, California, Forenede Stater, 91105
- Keck Medical Center of USC Pasadena
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Redwood City, California, Forenede Stater, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, Forenede Stater, 94801
- Kaiser Permanente-Richmond
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Riverside, California, Forenede Stater, 92505
- Kaiser Permanente-Riverside
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Roseville, California, Forenede Stater, 95661
- Kaiser Permanente-Roseville
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Roseville, California, Forenede Stater, 95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
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Roseville, California, Forenede Stater, 95661
- Sutter Roseville Medical Center
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Sacramento, California, Forenede Stater, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, Forenede Stater, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, Forenede Stater, 95825
- Kaiser Permanente - Sacramento
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San Diego, California, Forenede Stater, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, Forenede Stater, 92108
- Kaiser Permanente-San Diego Mission
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San Diego, California, Forenede Stater, 92103
- University of California San Diego
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San Francisco, California, Forenede Stater, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, Forenede Stater, 94115
- California Pacific Medical Center-Pacific Campus
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San Jose, California, Forenede Stater, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, Forenede Stater, 94577
- Kaiser Permanente San Leandro
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San Marcos, California, Forenede Stater, 92078
- Kaiser Permanente-San Marcos
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San Rafael, California, Forenede Stater, 94903
- Kaiser San Rafael-Gallinas
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San Rafael, California, Forenede Stater, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, Forenede Stater, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Cruz, California, Forenede Stater, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Rosa, California, Forenede Stater, 95403
- Kaiser Permanente-Santa Rosa
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Santa Rosa, California, Forenede Stater, 95403
- Sutter Pacific Medical Foundation
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South San Francisco, California, Forenede Stater, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, Forenede Stater, 95210
- Kaiser Permanente-Stockton
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Sunnyvale, California, Forenede Stater, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Vacaville, California, Forenede Stater, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vacaville, California, Forenede Stater, 95687
- Sutter Cancer Centers Radiation Oncology Services-Vacaville
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Vallejo, California, Forenede Stater, 94589
- Kaiser Permanente-Vallejo
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Vallejo, California, Forenede Stater, 94589
- Sutter Solano Medical Center/Cancer Center
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Walnut Creek, California, Forenede Stater, 94596
- Kaiser Permanente-Walnut Creek
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Woodland Hills, California, Forenede Stater, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, Forenede Stater, 80045
- University Of Colorado Hospital
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Colorado Springs, Colorado, Forenede Stater, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Forenede Stater, 80909
- UCHealth Memorial Hospital Central
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Colorado Springs, Colorado, Forenede Stater, 80907
- Rocky Mountain Cancer Centers-Penrose
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Denver, Colorado, Forenede Stater, 80210
- Porter Adventist Hospital
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Durango, Colorado, Forenede Stater, 81301
- Mercy Medical Center
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Durango, Colorado, Forenede Stater, 81301
- Southwest Oncology PC
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Fort Collins, Colorado, Forenede Stater, 80524
- Poudre Valley Hospital
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Golden, Colorado, Forenede Stater, 80401
- Mountain Blue Cancer Care Center
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Grand Junction, Colorado, Forenede Stater, 81505
- Grand Valley Oncology
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Lakewood, Colorado, Forenede Stater, 80228
- Saint Anthony Hospital
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Lakewood, Colorado, Forenede Stater, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Littleton, Colorado, Forenede Stater, 80122
- Littleton Adventist Hospital
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Longmont, Colorado, Forenede Stater, 80501
- Longmont United Hospital
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Longmont, Colorado, Forenede Stater, 80501
- Rocky Mountain Cancer Centers-Longmont
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Parker, Colorado, Forenede Stater, 80138
- Parker Adventist Hospital
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Parker, Colorado, Forenede Stater, 80138
- Rocky Mountain Cancer Centers-Parker
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Pueblo, Colorado, Forenede Stater, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, Forenede Stater, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, Forenede Stater, 80260
- Rocky Mountain Cancer Centers-Thornton
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Connecticut
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Hartford, Connecticut, Forenede Stater, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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West Haven, Connecticut, Forenede Stater, 06516
- Veterans Affairs Connecticut Healthcare System-West Haven Campus
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Delaware
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Lewes, Delaware, Forenede Stater, 19958
- Beebe Medical Center
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Newark, Delaware, Forenede Stater, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Forenede Stater, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Forenede Stater, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Forenede Stater, 19718
- Christiana Care Health System-Christiana Hospital
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Newark, Delaware, Forenede Stater, 19713
- Christiana Gynecologic Oncology LLC
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Rehoboth Beach, Delaware, Forenede Stater, 19971
- Beebe Health Campus
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Seaford, Delaware, Forenede Stater, 19973
- Nanticoke Memorial Hospital
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Wilmington, Delaware, Forenede Stater, 19801
- Christiana Care Health System-Wilmington Hospital
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Florida
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Coral Springs, Florida, Forenede Stater, 33065
- UM Sylvester Comprehensive Cancer Center at Coral Springs
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Deerfield Beach, Florida, Forenede Stater, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Fort Myers, Florida, Forenede Stater, 33905
- Regional Cancer Center-Lee Memorial Health System
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Hollywood, Florida, Forenede Stater, 33021
- UM Sylvester Comprehensive Cancer Center at Hollywood
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Lakeland, Florida, Forenede Stater, 33805
- The Watson Clinic
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Miami, Florida, Forenede Stater, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Miami, Florida, Forenede Stater, 33176
- UM Sylvester Comprehensive Cancer Center at Kendall
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Miami, Florida, Forenede Stater, 33136
- Jackson Memorial Hospital-Holtz Children's Hospital
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Plantation, Florida, Forenede Stater, 33324
- UM Sylvester Comprehensive Cancer Center at Plantation
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Weston, Florida, Forenede Stater, 33331
- Cleveland Clinic-Weston
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Georgia
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Atlanta, Georgia, Forenede Stater, 30308
- Emory University Hospital Midtown
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Atlanta, Georgia, Forenede Stater, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, Forenede Stater, 30342
- Emory Saint Joseph's Hospital
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Atlanta, Georgia, Forenede Stater, 30303
- Grady Health System
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Hawaii
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'Aiea, Hawaii, Forenede Stater, 96701
- Pali Momi Medical Center
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'Aiea, Hawaii, Forenede Stater, 96701
- The Cancer Center of Hawaii-Pali Momi
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'Aiea, Hawaii, Forenede Stater, 96701
- Hawaii Oncology Inc-Pali Momi
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Honolulu, Hawaii, Forenede Stater, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Forenede Stater, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Forenede Stater, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Forenede Stater, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Forenede Stater, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, Forenede Stater, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Forenede Stater, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, Forenede Stater, 96813
- Island Urology
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Honolulu, Hawaii, Forenede Stater, 96819
- Kaiser Permanente Moanalua Medical Center
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Honolulu, Hawaii, Forenede Stater, 96813
- Hawaii Cancer Care Inc-POB II
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Honolulu, Hawaii, Forenede Stater, 96813
- Hawaii Oncology Inc-POB I
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Honolulu, Hawaii, Forenede Stater, 96817
- Hawaii Oncology Inc-Kuakini
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Lihue, Hawaii, Forenede Stater, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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Idaho
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Boise, Idaho, Forenede Stater, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, Forenede Stater, 83712
- Saint Luke's Mountain States Tumor Institute
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Caldwell, Idaho, Forenede Stater, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, Forenede Stater, 83814
- Kootenai Medical Center
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Emmett, Idaho, Forenede Stater, 83617
- Walter Knox Memorial Hospital
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Fruitland, Idaho, Forenede Stater, 83619
- Saint Luke's Mountain States Tumor Institute - Fruitland
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Meridian, Idaho, Forenede Stater, 83642
- Idaho Urologic Institute-Meridian
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Meridian, Idaho, Forenede Stater, 83642
- Saint Luke's Mountain States Tumor Institute - Meridian
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Nampa, Idaho, Forenede Stater, 83686
- Saint Alphonsus Medical Center-Nampa
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Nampa, Idaho, Forenede Stater, 83686
- Saint Luke's Mountain States Tumor Institute - Nampa
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Post Falls, Idaho, Forenede Stater, 83854
- Kootenai Cancer Center
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Sandpoint, Idaho, Forenede Stater, 83864
- Kootenai Cancer Clinic
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Twin Falls, Idaho, Forenede Stater, 83301
- Saint Luke's Mountain States Tumor Institute-Twin Falls
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Illinois
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Aurora, Illinois, Forenede Stater, 60504
- Rush - Copley Medical Center
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Bloomington, Illinois, Forenede Stater, 61704
- Illinois CancerCare-Bloomington
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Bloomington, Illinois, Forenede Stater, 61701
- Saint Joseph Medical Center
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Canton, Illinois, Forenede Stater, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, Forenede Stater, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, Forenede Stater, 62918
- SIH Cancer Institute
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Carthage, Illinois, Forenede Stater, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Forenede Stater, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, Forenede Stater, 60637
- University of Chicago Comprehensive Cancer Center
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Danville, Illinois, Forenede Stater, 61832
- Carle on Vermilion
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DeKalb, Illinois, Forenede Stater, 60115
- Northwestern Medicine Cancer Center Kishwaukee
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Decatur, Illinois, Forenede Stater, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Forenede Stater, 62526
- Cancer Care Specialists of Illinois - Decatur
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Effingham, Illinois, Forenede Stater, 62401
- Crossroads Cancer Center
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Effingham, Illinois, Forenede Stater, 62401
- Carle Physician Group-Effingham
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Eureka, Illinois, Forenede Stater, 61530
- Illinois CancerCare-Eureka
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Galesburg, Illinois, Forenede Stater, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, Forenede Stater, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, Forenede Stater, 60134
- Northwestern Medicine Cancer Center Delnor
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Kewanee, Illinois, Forenede Stater, 61443
- Illinois CancerCare-Kewanee Clinic
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Macomb, Illinois, Forenede Stater, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, Forenede Stater, 61938
- Carle Physician Group-Mattoon/Charleston
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Moline, Illinois, Forenede Stater, 61265
- Garneau, Stewart C MD (UIA Investigator)
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Moline, Illinois, Forenede Stater, 61265
- Spector, David MD (UIA Investigator)
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Moline, Illinois, Forenede Stater, 61265
- Trinity Medical Center
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Mount Vernon, Illinois, Forenede Stater, 62864
- Good Samaritan Regional Health Center
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New Lenox, Illinois, Forenede Stater, 60451
- UC Comprehensive Cancer Center at Silver Cross
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Orland Park, Illinois, Forenede Stater, 60462
- University of Chicago Medicine-Orland Park
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Ottawa, Illinois, Forenede Stater, 61350
- Illinois CancerCare-Ottawa Clinic
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Ottawa, Illinois, Forenede Stater, 61350
- Radiation Oncology of Northern Illinois
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Pekin, Illinois, Forenede Stater, 61554
- Illinois CancerCare-Pekin
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Pekin, Illinois, Forenede Stater, 61554
- OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
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Peoria, Illinois, Forenede Stater, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, Forenede Stater, 61637
- OSF Saint Francis Medical Center
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Peoria, Illinois, Forenede Stater, 61615
- Illinois CancerCare-Peoria
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Peoria, Illinois, Forenede Stater, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
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Peru, Illinois, Forenede Stater, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, Forenede Stater, 61354
- Valley Radiation Oncology
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Princeton, Illinois, Forenede Stater, 61356
- Illinois CancerCare-Princeton
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Springfield, Illinois, Forenede Stater, 62781
- Memorial Medical Center
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Springfield, Illinois, Forenede Stater, 62702
- Southern Illinois University School of Medicine
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Springfield, Illinois, Forenede Stater, 62702
- Springfield Clinic
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Springfield, Illinois, Forenede Stater, 62702
- Central Illinois Hematology Oncology Center
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Swansea, Illinois, Forenede Stater, 62226
- Southwest Illinois Health Services LLP
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Swansea, Illinois, Forenede Stater, 62226
- Cancer Care Specialists of Illinois-Swansea
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Urbana, Illinois, Forenede Stater, 61801
- Carle Cancer Center
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Urbana, Illinois, Forenede Stater, 61801
- The Carle Foundation Hospital
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Warrenville, Illinois, Forenede Stater, 60555
- Northwestern Medicine Cancer Center Warrenville
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Yorkville, Illinois, Forenede Stater, 60560
- Rush-Copley Healthcare Center
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Indiana
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Evansville, Indiana, Forenede Stater, 47713
- Deaconess Clinic Downtown
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Fort Wayne, Indiana, Forenede Stater, 46805
- Parkview Hospital Randallia
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Fort Wayne, Indiana, Forenede Stater, 46804
- Radiation Oncology Associates PC
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Indianapolis, Indiana, Forenede Stater, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
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Indianapolis, Indiana, Forenede Stater, 46202
- Sidney and Lois Eskenazi Hospital
-
Michigan City, Indiana, Forenede Stater, 46360
- Franciscan Saint Anthony Health-Michigan City
-
Michigan City, Indiana, Forenede Stater, 46360
- Woodland Cancer Care Center
-
Newburgh, Indiana, Forenede Stater, 47630
- Chancellor Center for Oncology
-
Richmond, Indiana, Forenede Stater, 47374
- Reid Health
-
-
Iowa
-
Ames, Iowa, Forenede Stater, 50010
- McFarland Clinic PC - Ames
-
Ames, Iowa, Forenede Stater, 50010
- Mary Greeley Medical Center
-
Bettendorf, Iowa, Forenede Stater, 52722
- Constantinou, Costas L MD (UIA Investigator)
-
Boone, Iowa, Forenede Stater, 50036
- McFarland Clinic PC-Boone
-
Clive, Iowa, Forenede Stater, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Forenede Stater, 50325
- Medical Oncology and Hematology Associates-West Des Moines
-
Council Bluffs, Iowa, Forenede Stater, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, Forenede Stater, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, Forenede Stater, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Forenede Stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forenede Stater, 50309
- Medical Oncology and Hematology Associates-Des Moines
-
Des Moines, Iowa, Forenede Stater, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, Forenede Stater, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Forenede Stater, 50314
- Medical Oncology and Hematology Associates-Laurel
-
Fort Dodge, Iowa, Forenede Stater, 50501
- McFarland Clinic PC-Trinity Cancer Center
-
Jefferson, Iowa, Forenede Stater, 50129
- McFarland Clinic PC-Jefferson
-
Marshalltown, Iowa, Forenede Stater, 50158
- McFarland Clinic PC-Marshalltown
-
West Des Moines, Iowa, Forenede Stater, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Forenede Stater, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, Forenede Stater, 66720
- Cancer Center of Kansas - Chanute
-
Coffeyville, Kansas, Forenede Stater, 67337
- Coffeyville Regional Medical Center
-
Dodge City, Kansas, Forenede Stater, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Forenede Stater, 67042
- Cancer Center of Kansas - El Dorado
-
Fort Scott, Kansas, Forenede Stater, 66701
- Cancer Center of Kansas - Fort Scott
-
Garden City, Kansas, Forenede Stater, 67846
- Central Care Cancer Center - Garden City
-
Garden City, Kansas, Forenede Stater, 67846
- Saint Catherine Hospital
-
Great Bend, Kansas, Forenede Stater, 67530
- Central Care Cancer Center - Great Bend
-
Great Bend, Kansas, Forenede Stater, 67530
- Saint Rose Ambulatory and Surgery Center
-
Hays, Kansas, Forenede Stater, 67601
- Hays Medical Center
-
Independence, Kansas, Forenede Stater, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, Forenede Stater, 66160
- University of Kansas Cancer Center
-
Kansas City, Kansas, Forenede Stater, 66112
- University of Kansas Cancer Center-West
-
Kingman, Kansas, Forenede Stater, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Forenede Stater, 66044
- Lawrence Memorial Hospital
-
Lenexa, Kansas, Forenede Stater, 66219
- Kansas Institute of Medicine Cancer and Blood Center
-
Lenexa, Kansas, Forenede Stater, 66219
- Minimally Invasive Surgery Hospital
-
Liberal, Kansas, Forenede Stater, 67905
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, Forenede Stater, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, Forenede Stater, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, Forenede Stater, 67114
- Cancer Center of Kansas - Newton
-
Olathe, Kansas, Forenede Stater, 66061
- Olathe Medical Center
-
Overland Park, Kansas, Forenede Stater, 66210
- University of Kansas Cancer Center-Overland Park
-
Overland Park, Kansas, Forenede Stater, 66209
- Menorah Medical Center
-
Overland Park, Kansas, Forenede Stater, 66213
- Saint Luke's South Hospital
-
Parsons, Kansas, Forenede Stater, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, Forenede Stater, 66762
- Via Christi Hospital-Pittsburg
-
Prairie Village, Kansas, Forenede Stater, 66208
- Kansas City NCI Community Oncology Research Program
-
Pratt, Kansas, Forenede Stater, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Forenede Stater, 67401
- Salina Regional Health Center
-
Salina, Kansas, Forenede Stater, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, Forenede Stater, 66606
- Saint Francis Hospital and Medical Center - Topeka
-
Wellington, Kansas, Forenede Stater, 67152
- Cancer Center of Kansas - Wellington
-
Westwood, Kansas, Forenede Stater, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, Forenede Stater, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Forenede Stater, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Forenede Stater, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, Forenede Stater, 67208
- Associates In Womens Health
-
Winfield, Kansas, Forenede Stater, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Bardstown, Kentucky, Forenede Stater, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, Forenede Stater, 40701
- Baptist Health Corbin
-
Corbin, Kentucky, Forenede Stater, 40701
- Commonwealth Cancer Center-Corbin
-
Crestview Hills, Kentucky, Forenede Stater, 41017
- Oncology Hematology Care Inc-Crestview
-
Elizabethtown, Kentucky, Forenede Stater, 42701
- Hardin Memorial Hospital
-
Lexington, Kentucky, Forenede Stater, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, Forenede Stater, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Forenede Stater, 40509
- Saint Joseph Hospital East
-
Lexington, Kentucky, Forenede Stater, 40503
- Baptist Health Lexington
-
London, Kentucky, Forenede Stater, 40741
- Saint Joseph London
-
Louisville, Kentucky, Forenede Stater, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Forenede Stater, 40202
- Jewish Hospital
-
Louisville, Kentucky, Forenede Stater, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, Forenede Stater, 40215
- Saints Mary and Elizabeth Hospital
-
Louisville, Kentucky, Forenede Stater, 40245
- Jewish Hospital Medical Center Northeast
-
Madisonville, Kentucky, Forenede Stater, 42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
-
Paducah, Kentucky, Forenede Stater, 42003
- Baptist Health Paducah
-
Shepherdsville, Kentucky, Forenede Stater, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Ochsner Health Center-Summa
-
Baton Rouge, Louisiana, Forenede Stater, 70816
- Medical Center of Baton Rouge
-
Kenner, Louisiana, Forenede Stater, 70065
- Ochsner Medical Center Kenner
-
Monroe, Louisiana, Forenede Stater, 71202
- University Health-Conway
-
New Orleans, Louisiana, Forenede Stater, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, Forenede Stater, 70112
- University Medical Center New Orleans
-
New Orleans, Louisiana, Forenede Stater, 70112
- Louisiana State University Health Science Center
-
Shreveport, Louisiana, Forenede Stater, 71103
- Louisiana State University Health Sciences Center Shreveport
-
-
Maine
-
Augusta, Maine, Forenede Stater, 04330
- Harold Alfond Center for Cancer Care
-
Brewer, Maine, Forenede Stater, 04412
- Lafayette Family Cancer Center-EMMC
-
Rockport, Maine, Forenede Stater, 04856
- Penobscot Bay Medical Center
-
-
Maryland
-
Frederick, Maryland, Forenede Stater, 21701
- Frederick Memorial Hospital
-
-
Massachusetts
-
Boston, Massachusetts, Forenede Stater, 02118
- Boston Medical Center
-
Burlington, Massachusetts, Forenede Stater, 01805
- Lahey Hospital and Medical Center
-
Springfield, Massachusetts, Forenede Stater, 01199
- Baystate Medical Center
-
Winchester, Massachusetts, Forenede Stater, 01890
- Winchester Hospital
-
-
Michigan
-
Adrian, Michigan, Forenede Stater, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, Forenede Stater, 48109
- University Of Michigan Comprehensive Cancer Center
-
Ann Arbor, Michigan, Forenede Stater, 48106
- Saint Joseph Mercy Hospital
-
Battle Creek, Michigan, Forenede Stater, 49017
- Bronson Battle Creek
-
Brighton, Michigan, Forenede Stater, 48114
- Saint Joseph Mercy Brighton
-
Brighton, Michigan, Forenede Stater, 48114
- IHA Hematology Oncology Consultants-Brighton
-
Canton, Michigan, Forenede Stater, 48188
- Saint Joseph Mercy Canton
-
Canton, Michigan, Forenede Stater, 48188
- IHA Hematology Oncology Consultants-Canton
-
Caro, Michigan, Forenede Stater, 48723
- Caro Cancer Center
-
Chelsea, Michigan, Forenede Stater, 48118
- Saint Joseph Mercy Chelsea
-
Chelsea, Michigan, Forenede Stater, 48118
- IHA Hematology Oncology Consultants-Chelsea
-
Clarkston, Michigan, Forenede Stater, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, Forenede Stater, 48346
- Newland Medical Associates-Clarkston
-
Dearborn, Michigan, Forenede Stater, 48124
- Beaumont Hospital - Dearborn
-
Detroit, Michigan, Forenede Stater, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, Forenede Stater, 48236
- Ascension Saint John Hospital
-
East China Township, Michigan, Forenede Stater, 48054
- Great Lakes Cancer Management Specialists-Doctors Park
-
Farmington Hills, Michigan, Forenede Stater, 48334
- Weisberg Cancer Treatment Center
-
Farmington Hills, Michigan, Forenede Stater, 48336
- Beaumont Hospital - Farmington Hills
-
Flint, Michigan, Forenede Stater, 48503
- Hurley Medical Center
-
Flint, Michigan, Forenede Stater, 48503
- Genesee Cancer and Blood Disease Treatment Center
-
Flint, Michigan, Forenede Stater, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, Forenede Stater, 48503
- Genesys Hurley Cancer Institute
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Spectrum Health at Butterworth Campus
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Mercy Health Saint Mary's
-
Grosse Pointe, Michigan, Forenede Stater, 48230
- William Beaumont Hospital-Grosse Point
-
Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Academic Hematology Oncology Specialists
-
Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
-
Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Michigan Breast Specialists-Grosse Pointe Woods
-
Jackson, Michigan, Forenede Stater, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Forenede Stater, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Forenede Stater, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Forenede Stater, 49048
- Borgess Medical Center
-
Lansing, Michigan, Forenede Stater, 48912
- Sparrow Hospital
-
Livonia, Michigan, Forenede Stater, 48154
- Saint Mary Mercy Hospital
-
Livonia, Michigan, Forenede Stater, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, Forenede Stater, 48044
- Great Lakes Cancer Management Specialists-Macomb Medical Campus
-
Macomb, Michigan, Forenede Stater, 48044
- Michigan Breast Specialists-Macomb Township
-
Marlette, Michigan, Forenede Stater, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Monroe, Michigan, Forenede Stater, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Monroe, Michigan, Forenede Stater, 48162
- Monroe Cancer Center
-
Muskegon, Michigan, Forenede Stater, 49444
- Mercy Health Mercy Campus
-
Niles, Michigan, Forenede Stater, 49120
- Lakeland Hospital Niles
-
Pontiac, Michigan, Forenede Stater, 48341
- Saint Joseph Mercy Oakland
-
Pontiac, Michigan, Forenede Stater, 48341
- 21st Century Oncology-Pontiac
-
Pontiac, Michigan, Forenede Stater, 48341
- Hope Cancer Center
-
Pontiac, Michigan, Forenede Stater, 48341
- Newland Medical Associates-Pontiac
-
Reed City, Michigan, Forenede Stater, 49677
- Spectrum Health Reed City Hospital
-
Rochester Hills, Michigan, Forenede Stater, 48309
- Great Lakes Cancer Management Specialists-Rochester Hills
-
Roseville, Michigan, Forenede Stater, 48066
- Michigan Cancer Specialists
-
Royal Oak, Michigan, Forenede Stater, 48073
- William Beaumont Hospital-Royal Oak
-
Royal Oak, Michigan, Forenede Stater, 48067
- Oakland Colon and Rectal Association
-
Royal Oak, Michigan, Forenede Stater, 48073
- Cancer Care Associates PC
-
Royal Oak, Michigan, Forenede Stater, 48073
- Comprehensive Medical Center PLLC
-
Royal Oak, Michigan, Forenede Stater, 48073
- Hematology Oncology Consultants PC
-
Royal Oak, Michigan, Forenede Stater, 48073
- Oakland Medical Group
-
Saginaw, Michigan, Forenede Stater, 48601
- Ascension Saint Mary's Hospital
-
Saginaw, Michigan, Forenede Stater, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Lakeland Medical Center Saint Joseph
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Marie Yeager Cancer Center
-
Sterling Heights, Michigan, Forenede Stater, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Sterling Heights, Michigan, Forenede Stater, 48312
- Premier Hematology Oncology Care
-
Sterling Heights, Michigan, Forenede Stater, 48314
- Mitchell Folbe MD PC
-
Tawas City, Michigan, Forenede Stater, 48764
- Ascension Saint Joseph Hospital
-
Traverse City, Michigan, Forenede Stater, 49684
- Munson Medical Center
-
Troy, Michigan, Forenede Stater, 48085
- William Beaumont Hospital - Troy
-
Troy, Michigan, Forenede Stater, 48084
- Michigan Institute of Urology-Town Center
-
Troy, Michigan, Forenede Stater, 48085
- Claudia BR Herke MD PC
-
Troy, Michigan, Forenede Stater, 48098
- Hematology Oncology Consultants PC-Troy
-
Warren, Michigan, Forenede Stater, 48093
- Saint John Macomb-Oakland Hospital
-
Warren, Michigan, Forenede Stater, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, Forenede Stater, 48093
- Great Lakes Cancer Management Specialists-Macomb Professional Building
-
Warren, Michigan, Forenede Stater, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, Forenede Stater, 48093
- Michigan Breast Specialists-Warren
-
West Branch, Michigan, Forenede Stater, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyoming, Michigan, Forenede Stater, 49519
- Metro Health Hospital
-
Ypsilanti, Michigan, Forenede Stater, 48106
- Huron Gastroenterology PC
-
Ypsilanti, Michigan, Forenede Stater, 48197
- IHA Hematology Oncology Consultants-Ann Arbor
-
-
Minnesota
-
Bemidji, Minnesota, Forenede Stater, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Forenede Stater, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Forenede Stater, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Forenede Stater, 55433
- Mercy Hospital
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Forenede Stater, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Forenede Stater, 55435
- Fairview-Southdale Hospital
-
Fergus Falls, Minnesota, Forenede Stater, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, Forenede Stater, 55432
- Unity Hospital
-
Hibbing, Minnesota, Forenede Stater, 55746
- Essentia Health Hibbing Clinic
-
Maple Grove, Minnesota, Forenede Stater, 55369
- Fairview Maple Grove Medical Center
-
Maplewood, Minnesota, Forenede Stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forenede Stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forenede Stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Forenede Stater, 55454
- Health Partners Inc
-
New Ulm, Minnesota, Forenede Stater, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, Forenede Stater, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Forenede Stater, 55905
- Mayo Clinic
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Forenede Stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forenede Stater, 55102
- United Hospital
-
Shakopee, Minnesota, Forenede Stater, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Forenede Stater, 55082
- Lakeview Hospital
-
Virginia, Minnesota, Forenede Stater, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, Forenede Stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forenede Stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forenede Stater, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Wyoming, Minnesota, Forenede Stater, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Columbus, Mississippi, Forenede Stater, 39705
- Baptist Memorial Hospital and Cancer Center-Golden Triangle
-
Grenada, Mississippi, Forenede Stater, 38901
- Baptist Cancer Center-Grenada
-
Hattiesburg, Mississippi, Forenede Stater, 39401
- Hattiesburg Clinic - Hematology/Oncology Clinic
-
New Albany, Mississippi, Forenede Stater, 38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford, Mississippi, Forenede Stater, 38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Southhaven, Mississippi, Forenede Stater, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Ballwin, Missouri, Forenede Stater, 63011
- Saint Louis Cancer and Breast Institute-Ballwin
-
Bolivar, Missouri, Forenede Stater, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, Forenede Stater, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Forenede Stater, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Southeast Cancer Center
-
Columbia, Missouri, Forenede Stater, 65212
- University of Missouri - Ellis Fischel
-
Creve Coeur, Missouri, Forenede Stater, 63141
- Siteman Cancer Center at West County Hospital
-
Independence, Missouri, Forenede Stater, 64057
- Centerpoint Medical Center LLC
-
Jefferson City, Missouri, Forenede Stater, 65109
- Capital Region Southwest Campus
-
Joplin, Missouri, Forenede Stater, 64804
- Freeman Health System
-
Joplin, Missouri, Forenede Stater, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, Forenede Stater, 64128
- Kansas City Veterans Affairs Medical Center
-
Kansas City, Missouri, Forenede Stater, 64131
- The University of Kansas Cancer Center-South
-
Kansas City, Missouri, Forenede Stater, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, Forenede Stater, 64132
- Research Medical Center
-
Kansas City, Missouri, Forenede Stater, 64108
- Truman Medical Center
-
Kansas City, Missouri, Forenede Stater, 64118
- Heartland Hematology and Oncology Associates Incorporated
-
Kansas City, Missouri, Forenede Stater, 64154
- The University of Kansas Cancer Center-North
-
Lee's Summit, Missouri, Forenede Stater, 64086
- Saint Luke's East - Lee's Summit
-
Lee's Summit, Missouri, Forenede Stater, 64064
- The University of Kansas Cancer Center-Lee's Summit
-
Liberty, Missouri, Forenede Stater, 64068
- Liberty Radiation Oncology Center
-
Rolla, Missouri, Forenede Stater, 65401
- Delbert Day Cancer Institute at PCRMC
-
Rolla, Missouri, Forenede Stater, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Saint Joseph, Missouri, Forenede Stater, 64507
- Heartland Regional Medical Center
-
Saint Louis, Missouri, Forenede Stater, 63110
- Washington University School of Medicine
-
Saint Louis, Missouri, Forenede Stater, 63131
- Missouri Baptist Medical Center
-
Saint Louis, Missouri, Forenede Stater, 63141
- Mercy Hospital Saint Louis
-
Saint Louis, Missouri, Forenede Stater, 63129
- Siteman Cancer Center-South County
-
Saint Louis, Missouri, Forenede Stater, 63136
- Siteman Cancer Center at Christian Hospital
-
Saint Louis, Missouri, Forenede Stater, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Saint Peters, Missouri, Forenede Stater, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Sainte Genevieve, Missouri, Forenede Stater, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Forenede Stater, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Forenede Stater, 65804
- Mercy Hospital Springfield
-
Sullivan, Missouri, Forenede Stater, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, Forenede Stater, 63127
- Missouri Baptist Outpatient Center-Sunset Hills
-
Washington, Missouri, Forenede Stater, 63090
- Mercy Hospital Washington
-
-
Montana
-
Billings, Montana, Forenede Stater, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Forenede Stater, 59101
- Saint Vincent Healthcare
-
Bozeman, Montana, Forenede Stater, 59715
- Bozeman Deaconess Hospital
-
Butte, Montana, Forenede Stater, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Forenede Stater, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Helena, Montana, Forenede Stater, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Forenede Stater, 59901
- Kalispell Regional Medical Center
-
Missoula, Montana, Forenede Stater, 59804
- Community Medical Hospital
-
Missoula, Montana, Forenede Stater, 59802
- Saint Patrick Hospital - Community Hospital
-
-
Nebraska
-
Grand Island, Nebraska, Forenede Stater, 68803
- CHI Health Saint Francis
-
Kearney, Nebraska, Forenede Stater, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, Forenede Stater, 68845
- Heartland Hematology and Oncology
-
Lincoln, Nebraska, Forenede Stater, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, Forenede Stater, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, Forenede Stater, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, Forenede Stater, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Forenede Stater, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Forenede Stater, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Forenede Stater, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, Forenede Stater, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, Forenede Stater, 68046
- Midlands Community Hospital
-
-
New Hampshire
-
Lebanon, New Hampshire, Forenede Stater, 03756
- Dartmouth Hitchcock Medical Center
-
Manchester, New Hampshire, Forenede Stater, 03102
- Norris Cotton Cancer Center-Manchester
-
Nashua, New Hampshire, Forenede Stater, 03063
- Norris Cotton Cancer Center-Nashua
-
-
New Jersey
-
Englewood, New Jersey, Forenede Stater, 07631
- Englewood Hospital and Medical Center
-
Woodbury, New Jersey, Forenede Stater, 08096
- Inspira Medical Center Woodbury
-
-
New Mexico
-
Albuquerque, New Mexico, Forenede Stater, 87102
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, Forenede Stater, 87102
- Lovelace Medical Center-Saint Joseph Square
-
Las Cruces, New Mexico, Forenede Stater, 88011
- Memorial Medical Center - Las Cruces
-
-
New York
-
Auburn, New York, Forenede Stater, 13021
- Hematology Oncology Associates of Central New York-Auburn
-
Bronx, New York, Forenede Stater, 10461
- Montefiore Medical Center-Einstein Campus
-
Bronx, New York, Forenede Stater, 10467
- Montefiore Medical Center - Moses Campus
-
Bronx, New York, Forenede Stater, 10461
- Montefiore Medical Center-Weiler Hospital
-
East Syracuse, New York, Forenede Stater, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Glens Falls, New York, Forenede Stater, 12801
- Glens Falls Hospital
-
Middletown, New York, Forenede Stater, 10940
- Orange Regional Medical Center
-
Mineola, New York, Forenede Stater, 11501
- NYU Winthrop Hospital
-
Poughkeepsie, New York, Forenede Stater, 12601
- Vassar Brothers Medical Center
-
Rochester, New York, Forenede Stater, 14642
- University of Rochester
-
Syracuse, New York, Forenede Stater, 13210
- State University of New York Upstate Medical University
-
Syracuse, New York, Forenede Stater, 13215
- Hematology Oncology Associates of Central New York-Onondaga Hill
-
-
North Carolina
-
Asheboro, North Carolina, Forenede Stater, 27203
- Randolph Hospital
-
Asheville, North Carolina, Forenede Stater, 28803
- AdventHealth Infusion Center Asheville
-
Burlington, North Carolina, Forenede Stater, 27215
- Cone Health Cancer Center at Alamance Regional
-
Clinton, North Carolina, Forenede Stater, 28328
- Southeastern Medical Oncology Center-Clinton
-
Durham, North Carolina, Forenede Stater, 27710
- Duke University Medical Center
-
Goldsboro, North Carolina, Forenede Stater, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Forenede Stater, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, Forenede Stater, 27403
- Cone Health Cancer Center
-
Hendersonville, North Carolina, Forenede Stater, 28792
- AdventHealth Hendersonville
-
Jacksonville, North Carolina, Forenede Stater, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Jacksonville, North Carolina, Forenede Stater, 28546
- Onslow Memorial Hospital
-
Kinston, North Carolina, Forenede Stater, 28501
- Vidant Oncology-Kinston
-
Leland, North Carolina, Forenede Stater, 28451
- Cape Fear Cancer Specialists-Leland
-
Mebane, North Carolina, Forenede Stater, 27302
- Cone Heath Cancer Center at Mebane
-
Reidsville, North Carolina, Forenede Stater, 27320
- Annie Penn Memorial Hospital
-
Wilmington, North Carolina, Forenede Stater, 28401
- New Hanover Regional Medical Center/Zimmer Cancer Center
-
Wilmington, North Carolina, Forenede Stater, 28401
- Cape Fear Cancer Specialists
-
Winston-Salem, North Carolina, Forenede Stater, 27104
- Southeast Clinical Oncology Research Consortium NCORP
-
-
North Dakota
-
Bismarck, North Dakota, Forenede Stater, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Forenede Stater, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Broadway Medical Center
-
-
Ohio
-
Akron, Ohio, Forenede Stater, 44307
- Cleveland Clinic Akron General
-
Beachwood, Ohio, Forenede Stater, 44122
- UHHS-Chagrin Highlands Medical Center
-
Beavercreek, Ohio, Forenede Stater, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, Forenede Stater, 45714
- Strecker Cancer Center-Belpre
-
Centerville, Ohio, Forenede Stater, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Forenede Stater, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chardon, Ohio, Forenede Stater, 44024
- Geauga Hospital
-
Chillicothe, Ohio, Forenede Stater, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Forenede Stater, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Forenede Stater, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Forenede Stater, 45242
- Oncology Hematology Care Inc-Blue Ash
-
Cincinnati, Ohio, Forenede Stater, 45202
- Oncology Hematology Care Inc-Eden Park
-
Cincinnati, Ohio, Forenede Stater, 45211
- Oncology Hematology Care Inc-Mercy West
-
Cincinnati, Ohio, Forenede Stater, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, Forenede Stater, 45219
- University of Cincinnati/Barrett Cancer Center
-
Cincinnati, Ohio, Forenede Stater, 45230
- Oncology Hematology Care Inc - Anderson
-
Cincinnati, Ohio, Forenede Stater, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Forenede Stater, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Forenede Stater, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Forenede Stater, 44109
- MetroHealth Medical Center
-
Cleveland, Ohio, Forenede Stater, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, Forenede Stater, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Columbus, Ohio, Forenede Stater, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Forenede Stater, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Forenede Stater, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Forenede Stater, 43228
- Doctors Hospital
-
Columbus, Ohio, Forenede Stater, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, Forenede Stater, 43215
- Grant Medical Center
-
Columbus, Ohio, Forenede Stater, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, Forenede Stater, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Forenede Stater, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Forenede Stater, 45415
- Dayton Physician LLC-Miami Valley Hospital North
-
Dayton, Ohio, Forenede Stater, 45415
- Miami Valley Hospital North
-
Delaware, Ohio, Forenede Stater, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Forenede Stater, 43015
- Delaware Radiation Oncology
-
Delaware, Ohio, Forenede Stater, 43015
- Grady Memorial Hospital
-
Elyria, Ohio, Forenede Stater, 44035
- Mercy Cancer Center-Elyria
-
Fairfield, Ohio, Forenede Stater, 45014
- Oncology Hematology Care Inc-Healthplex
-
Findlay, Ohio, Forenede Stater, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Forenede Stater, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Forenede Stater, 45840
- Orion Cancer Care
-
Franklin, Ohio, Forenede Stater, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Forenede Stater, 45005
- Dayton Physicians LLC-Atrium
-
Greenville, Ohio, Forenede Stater, 45331
- Wayne Hospital
-
Greenville, Ohio, Forenede Stater, 45331
- Dayton Physicians LLC-Wayne
-
Independence, Ohio, Forenede Stater, 44131
- Cleveland Clinic Cancer Center Independence
-
Kettering, Ohio, Forenede Stater, 45429
- Kettering Medical Center
-
Kettering, Ohio, Forenede Stater, 45409
- Greater Dayton Cancer Center
-
Kettering, Ohio, Forenede Stater, 45420
- First Dayton Cancer Care
-
Lancaster, Ohio, Forenede Stater, 43130
- Fairfield Medical Center
-
Mansfield, Ohio, Forenede Stater, 44906
- Cleveland Clinic Cancer Center Mansfield
-
Mansfield, Ohio, Forenede Stater, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, Forenede Stater, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, Forenede Stater, 43302
- OhioHealth Marion General Hospital
-
Maumee, Ohio, Forenede Stater, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, Forenede Stater, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Mayfield Heights, Ohio, Forenede Stater, 44124
- Hillcrest Hospital Cancer Center
-
Mayfield Heights, Ohio, Forenede Stater, 44124
- UH Seidman Cancer Center at Landerbrook Health Center
-
Mentor, Ohio, Forenede Stater, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middleburg Heights, Ohio, Forenede Stater, 44130
- UH Seidman Cancer Center at Southwest General Hospital
-
Middletown, Ohio, Forenede Stater, 45042
- Dayton Physicians LLC-Signal Point
-
Mount Vernon, Ohio, Forenede Stater, 43050
- Knox Community Hospital
-
Newark, Ohio, Forenede Stater, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Forenede Stater, 43055
- Newark Radiation Oncology
-
Oregon, Ohio, Forenede Stater, 43616
- Saint Charles Hospital
-
Parma, Ohio, Forenede Stater, 44129
- University Hospitals Parma Medical Center
-
Perrysburg, Ohio, Forenede Stater, 43551
- Mercy Health Perrysburg Cancer Center
-
Portsmouth, Ohio, Forenede Stater, 45662
- Southern Ohio Medical Center
-
Sandusky, Ohio, Forenede Stater, 44870
- North Coast Cancer Care
-
Sandusky, Ohio, Forenede Stater, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Sidney, Ohio, Forenede Stater, 45365
- Dayton Physicians LLC-Wilson
-
Springfield, Ohio, Forenede Stater, 45505
- Springfield Regional Medical Center
-
Springfield, Ohio, Forenede Stater, 45504
- Springfield Regional Cancer Center
-
Strongsville, Ohio, Forenede Stater, 44136
- Cleveland Clinic Cancer Center Strongsville
-
Sylvania, Ohio, Forenede Stater, 43560
- ProMedica Flower Hospital
-
Toledo, Ohio, Forenede Stater, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Forenede Stater, 43606
- The Toledo Hospital/Toledo Children's Hospital
-
Toledo, Ohio, Forenede Stater, 43623
- Mercy Saint Anne Hospital
-
Troy, Ohio, Forenede Stater, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Forenede Stater, 45373
- Dayton Physicians LLC-Upper Valley
-
Wadsworth, Ohio, Forenede Stater, 44281
- University Hospitals Sharon Health Center
-
Warrensville Heights, Ohio, Forenede Stater, 44122
- South Pointe Hospital
-
West Chester, Ohio, Forenede Stater, 45069
- University Pointe
-
Westerville, Ohio, Forenede Stater, 43081
- Saint Ann's Hospital
-
Westlake, Ohio, Forenede Stater, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Westlake, Ohio, Forenede Stater, 44145
- UHHS-Westlake Medical Center
-
Wooster, Ohio, Forenede Stater, 44691
- Cleveland Clinic Wooster Family Health and Surgery Center
-
Zanesville, Ohio, Forenede Stater, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Forenede Stater, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Forenede Stater, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Forenede Stater, 73120
- Mercy Hospital Oklahoma City
-
-
Oregon
-
Baker City, Oregon, Forenede Stater, 97814
- Saint Alphonsus Medical Center-Baker City
-
Bend, Oregon, Forenede Stater, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Forenede Stater, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Forenede Stater, 97015
- Providence Oncology and Hematology Care Southeast
-
Coos Bay, Oregon, Forenede Stater, 97420
- Bay Area Hospital
-
Gresham, Oregon, Forenede Stater, 97030
- Legacy Mount Hood Medical Center
-
Newberg, Oregon, Forenede Stater, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Forenede Stater, 97914
- Saint Alphonsus Medical Center-Ontario
-
Oregon City, Oregon, Forenede Stater, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, Forenede Stater, 97210
- Legacy Good Samaritan Hospital and Medical Center
-
Portland, Oregon, Forenede Stater, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Forenede Stater, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Forenede Stater, 97227
- Kaiser Permanente Northwest
-
Salem, Oregon, Forenede Stater, 97301
- Salem Hospital
-
Tualatin, Oregon, Forenede Stater, 97062
- Legacy Meridian Park Hospital
-
-
Pennsylvania
-
Abington, Pennsylvania, Forenede Stater, 19001
- Abington Memorial Hospital
-
Allentown, Pennsylvania, Forenede Stater, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Forenede Stater, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bethlehem, Pennsylvania, Forenede Stater, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Bryn Mawr, Pennsylvania, Forenede Stater, 19010
- Bryn Mawr Hospital
-
Chadds Ford, Pennsylvania, Forenede Stater, 19317
- Christiana Care Health System-Concord Health Center
-
Danville, Pennsylvania, Forenede Stater, 17822
- Geisinger Medical Center
-
Hazleton, Pennsylvania, Forenede Stater, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hershey, Pennsylvania, Forenede Stater, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Lewisburg, Pennsylvania, Forenede Stater, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Forenede Stater, 17044
- Lewistown Hospital
-
Media, Pennsylvania, Forenede Stater, 19063
- Riddle Memorial Hospital
-
Paoli, Pennsylvania, Forenede Stater, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, Forenede Stater, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19140
- Temple University Hospital
-
Pottsville, Pennsylvania, Forenede Stater, 17901
- Geisinger Cancer Services-Pottsville
-
Sayre, Pennsylvania, Forenede Stater, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
Scranton, Pennsylvania, Forenede Stater, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, Forenede Stater, 17870
- Geisinger Medical Oncology-Selinsgrove
-
Sellersville, Pennsylvania, Forenede Stater, 18960
- Grand View Hospital
-
State College, Pennsylvania, Forenede Stater, 16801
- Geisinger Medical Group
-
West Reading, Pennsylvania, Forenede Stater, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Wynnewood, Pennsylvania, Forenede Stater, 19096
- Lankenau Medical Center
-
-
South Carolina
-
Charleston, South Carolina, Forenede Stater, 29425
- Medical University of South Carolina
-
Charleston, South Carolina, Forenede Stater, 29401
- Roper Hospital
-
Charleston, South Carolina, Forenede Stater, 29406
- Lowcountry Hematology Oncology PA-North Charleston
-
Charleston, South Carolina, Forenede Stater, 29414
- Bon Secours Saint Francis Hospital
-
Charleston, South Carolina, Forenede Stater, 29414
- Lowcountry Hematology Oncology PA-West Ashley
-
Charleston, South Carolina, Forenede Stater, 29403
- Charleston Oncology - Roper
-
Charleston, South Carolina, Forenede Stater, 29414
- Charleston Oncology - Saint Francis
-
Easley, South Carolina, Forenede Stater, 29640
- Prisma Health Cancer Institute - Easley
-
Greenville, South Carolina, Forenede Stater, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Forenede Stater, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Forenede Stater, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Forenede Stater, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Forenede Stater, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, Forenede Stater, 29605
- Prisma Health Greenville Memorial Hospital
-
Greenville, South Carolina, Forenede Stater, 29601
- Greenville Health System Cancer Institute-Andrews
-
Greenwood, South Carolina, Forenede Stater, 29646
- Self Regional Healthcare
-
Greer, South Carolina, Forenede Stater, 29650
- Prisma Health Cancer Institute - Greer
-
Mount Pleasant, South Carolina, Forenede Stater, 29464
- Lowcountry Hematology Oncology PA-Mount Pleasant
-
Seneca, South Carolina, Forenede Stater, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Forenede Stater, 29307
- Prisma Health Cancer Institute - Spartanburg
-
-
South Dakota
-
Sioux Falls, South Dakota, Forenede Stater, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Forenede Stater, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Bristol, Tennessee, Forenede Stater, 37620
- Wellmont Medical Associates Oncology and Hematology-Bristol
-
Bristol, Tennessee, Forenede Stater, 37620
- Wellmont Bristol Regional Medical Center
-
Chattanooga, Tennessee, Forenede Stater, 37404
- Memorial Hospital
-
Collierville, Tennessee, Forenede Stater, 38017
- Integrity Oncology PLLC-Collierville
-
Franklin, Tennessee, Forenede Stater, 37067
- Vanderbilt-Ingram Cancer Center Cool Springs
-
Hixson, Tennessee, Forenede Stater, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Johnson City, Tennessee, Forenede Stater, 37604
- Wellmont Medical Associates Oncology and Hematology-Johnson City
-
Kingsport, Tennessee, Forenede Stater, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Kingsport, Tennessee, Forenede Stater, 37660
- Regional Cancer Center at Indian Path Community Hospital
-
Memphis, Tennessee, Forenede Stater, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
Memphis, Tennessee, Forenede Stater, 38120
- Baptist Memorial Hospital for Women
-
Memphis, Tennessee, Forenede Stater, 38120
- Family Cancer Center-Memphis
-
Nashville, Tennessee, Forenede Stater, 37232
- Vanderbilt University/Ingram Cancer Center
-
Nashville, Tennessee, Forenede Stater, 37204
- Vanderbilt Breast Center at One Hundred Oaks
-
Nashville, Tennessee, Forenede Stater, 37208
- Meharry Medical College
-
Ooltewah, Tennessee, Forenede Stater, 37363
- Memorial GYN Plus
-
-
Texas
-
Austin, Texas, Forenede Stater, 78705
- Texas Oncology-Austin Midtown
-
Austin, Texas, Forenede Stater, 78731
- Texas Oncology - Central Austin Cancer Center
-
Austin, Texas, Forenede Stater, 78745
- Texas Oncology - South Austin Cancer Center
-
Bryan, Texas, Forenede Stater, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, Forenede Stater, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, Forenede Stater, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Fort Worth, Texas, Forenede Stater, 76104
- UT Southwestern/Simmons Cancer Center-Fort Worth
-
Houston, Texas, Forenede Stater, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Houston, Texas, Forenede Stater, 77030
- Ben Taub General Hospital
-
Round Rock, Texas, Forenede Stater, 78681
- Texas Oncology - Round Rock Cancer Center
-
San Antonio, Texas, Forenede Stater, 78229
- University Hospital
-
San Antonio, Texas, Forenede Stater, 78229
- University of Texas Health Science Center at San Antonio
-
San Antonio, Texas, Forenede Stater, 78229
- Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
-
-
Utah
-
Farmington, Utah, Forenede Stater, 84025
- Farmington Health Center
-
Salt Lake City, Utah, Forenede Stater, 84112
- Huntsman Cancer Institute/University of Utah
-
South Jordan, Utah, Forenede Stater, 84009
- South Jordan Health Center
-
-
Vermont
-
Berlin, Vermont, Forenede Stater, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Forenede Stater, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Forenede Stater, 05405
- University of Vermont and State Agricultural College
-
Saint Johnsbury, Vermont, Forenede Stater, 05819
- Norris Cotton Cancer Center-North
-
-
Virginia
-
Bristol, Virginia, Forenede Stater, 24201
- Wellmont Medical Associates-Bristol
-
Mechanicsville, Virginia, Forenede Stater, 23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian, Virginia, Forenede Stater, 23114
- Bon Secours Saint Francis Medical Center
-
Norton, Virginia, Forenede Stater, 24273
- Southwest VA Regional Cancer Center
-
Richmond, Virginia, Forenede Stater, 23226
- Bon Secours Saint Mary's Hospital
-
-
Washington
-
Aberdeen, Washington, Forenede Stater, 98520
- Providence Regional Cancer System-Aberdeen
-
Anacortes, Washington, Forenede Stater, 98221
- Cancer Care Center at Island Hospital
-
Bellevue, Washington, Forenede Stater, 98005
- Swedish Cancer Institute-Eastside Oncology Hematology
-
Bellingham, Washington, Forenede Stater, 98225
- PeaceHealth Saint Joseph Medical Center
-
Bremerton, Washington, Forenede Stater, 98310
- Harrison HealthPartners Hematology and Oncology-Bremerton
-
Bremerton, Washington, Forenede Stater, 98310
- Harrison Medical Center
-
Burien, Washington, Forenede Stater, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, Forenede Stater, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Forenede Stater, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, Forenede Stater, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Forenede Stater, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Forenede Stater, 98003
- Saint Francis Hospital
-
Issaquah, Washington, Forenede Stater, 98029
- Swedish Cancer Institute-Issaquah
-
Lacey, Washington, Forenede Stater, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Forenede Stater, 98499
- Saint Clare Hospital
-
Longview, Washington, Forenede Stater, 98632
- PeaceHealth Saint John Medical Center
-
Poulsbo, Washington, Forenede Stater, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Seattle, Washington, Forenede Stater, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Forenede Stater, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, Forenede Stater, 98104
- Minor and James Medical PLLC
-
Seattle, Washington, Forenede Stater, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, Forenede Stater, 98122-4307
- Swedish Medical Center-First Hill
-
Shelton, Washington, Forenede Stater, 98584
- Providence Regional Cancer System-Shelton
-
Spokane, Washington, Forenede Stater, 99204
- Rockwood Cancer Treatment Center-DHEC-Downtown
-
Spokane, Washington, Forenede Stater, 99218
- Rockwood North Cancer Treatment Center
-
Spokane Valley, Washington, Forenede Stater, 99216
- Rockwood Clinic Cancer Treatment Center-Valley
-
Tacoma, Washington, Forenede Stater, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Forenede Stater, 98431
- Madigan Army Medical Center
-
Tacoma, Washington, Forenede Stater, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, Forenede Stater, 98686
- Legacy Salmon Creek Hospital
-
Vancouver, Washington, Forenede Stater, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Forenede Stater, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Forenede Stater, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, Forenede Stater, 98597
- Providence Regional Cancer System-Yelm
-
-
West Virginia
-
Charleston, West Virginia, Forenede Stater, 25304
- West Virginia University Charleston Division
-
-
Wisconsin
-
Antigo, Wisconsin, Forenede Stater, 54409
- Langlade Hospital and Cancer Center
-
Ashland, Wisconsin, Forenede Stater, 54806
- Duluth Clinic Ashland
-
Burlington, Wisconsin, Forenede Stater, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, Forenede Stater, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- HSHS Sacred Heart Hospital
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Fond Du Lac, Wisconsin, Forenede Stater, 54937
- Aurora Health Center-Fond du Lac
-
Germantown, Wisconsin, Forenede Stater, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Forenede Stater, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Forenede Stater, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Forenede Stater, 54301
- Bellin Memorial Hospital
-
Kenosha, Wisconsin, Forenede Stater, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Forenede Stater, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, Forenede Stater, 53792
- University of Wisconsin Hospital and Clinics
-
Marinette, Wisconsin, Forenede Stater, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, Forenede Stater, 54143
- Bay Area Medical Center
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Medical Center-Marshfield
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Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Medical Center
-
Milwaukee, Wisconsin, Forenede Stater, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Forenede Stater, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Forenede Stater, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, Forenede Stater, 54548
- Marshfield Clinic-Minocqua Center
-
Mukwonago, Wisconsin, Forenede Stater, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Forenede Stater, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Forenede Stater, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oshkosh, Wisconsin, Forenede Stater, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
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Racine, Wisconsin, Forenede Stater, 53406
- Aurora Cancer Care-Racine
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Rice Lake, Wisconsin, Forenede Stater, 54868
- Marshfield Medical Center-Rice Lake
-
Rice Lake, Wisconsin, Forenede Stater, 54868
- Lakeview Medical Center-Marshfield Clinic
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
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Stevens Point, Wisconsin, Forenede Stater, 54482
- Marshfield Clinic Stevens Point Center
-
Stevens Point, Wisconsin, Forenede Stater, 54481
- Ascension Saint Michael's Hospital
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Summit, Wisconsin, Forenede Stater, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Forenede Stater, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
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Waukesha, Wisconsin, Forenede Stater, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, Forenede Stater, 53188
- ProHealth Waukesha Memorial Hospital
-
Waukesha, Wisconsin, Forenede Stater, 53188
- Aurora Cancer Care-Waukesha
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Wausau, Wisconsin, Forenede Stater, 54401
- Aspirus Regional Cancer Center
-
Wausau, Wisconsin, Forenede Stater, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, Forenede Stater, 53226
- Aurora Cancer Care-Milwaukee West
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West Allis, Wisconsin, Forenede Stater, 53227
- Aurora West Allis Medical Center
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Weston, Wisconsin, Forenede Stater, 54476
- Ascension Saint Clare's Hospital
-
Weston, Wisconsin, Forenede Stater, 54476
- Marshfield Clinic - Weston Center
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Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Aspirus UW Cancer Center
-
-
Wyoming
-
Cody, Wyoming, Forenede Stater, 82414
- Big Horn Basin Cancer Center
-
Cody, Wyoming, Forenede Stater, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Forenede Stater, 82801
- Welch Cancer Center
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år til 75 år (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Alle
Beskrivelse
Inklusionskriterier:
- Patienter skal have histologisk eller cytologisk bevist pancreas adenocarcinom; andre histologier end adenokarcinom eller enhver blandet histologi vil IKKE være berettiget
- Patienter skal have målbar sygdom i bugspytkirtlen; computertomografi (CT)-scanninger eller magnetisk resonansbilleddannelse (MRI), der bruges til at vurdere målbar sygdom, skal være gennemført inden for 28 dage før registrering; al sygdom skal vurderes og dokumenteres på baseline tumorvurderingsskemaet
Patienter skal have resektabel primær tumor baseret på kontrastforstærket CT eller MR (CT eller MR uden kontrast som en del af positronemissionstomografi [PET]/CT eller PET/MRI er IKKE acceptabelt; CT eller MR med kontrast som en del af PET/CT eller PET/MRI er acceptabelt) af brystet, maven og bækkenet, hvor resektabel er defineret som:
- Ingen involvering af cøliakiarterien, almindelig leverarterie og mesenterial arterie superior (og, hvis til stede, erstattet højre leverarterie)
- Ingen involvering, eller < 180° grænseflade mellem tumor og karvæg, af portvenen og/eller mesenterialvenen superior; og patent på sammenløb af portalvene/miltvene
- Ingen tegn på metastatisk sygdom
- Bemærk: for tumorer i kroppen og bugspytkirtlens hale betragtes involvering af miltarterie og vene af enhver grad som resektabel sygdom
- CT-scanninger eller MRI'er, der bruges til at vurdere sygdom ved baseline, skal indsendes til central gennemgang
- Patienter skal have kirurgisk konsultation for at bekræfte, at patienten er en kirurgisk kandidat inden for 21 dage før registrering
- Patienter må ikke have modtaget tidligere kirurgi, strålebehandling, kemoterapi, målrettet terapi eller nogen form for undersøgelsesbehandling for bugspytkirtelkræft
- Patienter skal have en Zubrod præstationsstatus på 0-1
- Absolut neutrofiltal (ANC) >= 1.500/mcL
- Blodplader >= 100.000/mcL
- Hæmoglobin >= 9 g/dL
- Total bilirubin =< 1,5 x institutionel øvre normalgrænse (IULN)
- Aspartataminotransferase (AST) og alaninaminotransferase (ALT) =< 2,5 x IULN
- Serumalbumin >= 3 g/dL
- Serumkreatinin =< IULN inden for 14 dage før registrering
- Patienter med ukontrolleret interkurrent sygdom, herunder, men ikke begrænset til, igangværende eller aktiv infektion, symptomatisk kongestiv hjerteinsufficiens, ustabil angina pectoris, hjertearytmi eller psykiatrisk sygdom/sociale situationer, der ville begrænse overholdelse af undersøgelseskrav, vil IKKE være kvalificerede
- Ingen tidligere malignitet er tilladt undtagen for tilstrækkeligt behandlet basal (eller pladecelle) hudkræft, in situ livmoderhalskræft, in situ brystkræft (ductal eller lobulær) eller anden cancer, for hvilken patienten har været sygdoms- og behandlingsfri i to år
- Patienter må ikke være gravide eller ammende; kvinder/mænd med reproduktionspotentiale skal have accepteret at bruge en effektiv præventionsmetode i op til 3 måneder efter den sidste indgivne dosis kemoterapi; en kvinde anses for at have "reproduktionspotentiale", hvis hun har haft menstruation på noget tidspunkt i de foregående 12 på hinanden følgende måneder; ud over rutinepræventionsmetoder omfatter "effektiv prævention" også heteroseksuel cølibat og kirurgi beregnet til at forhindre graviditet (eller med en bivirkning af graviditetsforebyggelse) defineret som en hysterektomi, bilateral oophorektomi eller bilateral tubal ligering; men hvis en tidligere cølibatpatient på noget tidspunkt vælger at blive heteroseksuelt aktiv i løbet af tidsperioden for brug af præventionsmidler, er han/hun ansvarlig for at påbegynde præventionsforanstaltninger
- Sites skal søge yderligere patientsamtykke til fremtidig brug af prøver
- Patienterne skal informeres om undersøgelsens karakter af denne undersøgelse og skal underskrive og give skriftligt informeret samtykke i overensstemmelse med institutionelle og føderale retningslinjer
- Som en del af OPEN-registreringsprocessen oplyses den behandlende institutions identitet for at sikre, at den aktuelle (inden for 365 dage) dato for institutionens bedømmelsesudvalgs godkendelse af denne undersøgelse er blevet indtastet i systemet
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: Arm I (mFOLFIRINOX, kirurgi)
Patienterne får oxaliplatin IV over 2 timer og irinotecanhydrochlorid IV over 90 minutter på dag 1 og 15.
Patienterne får også 5-fluorouracil IV over 46 timer på dag 1-3 og 15-17.
Behandlingen gentages hver 28. dag i 3 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.
Patienter, der opnår stabil sygdom eller bedre, gennemgår pancreatektomi 4-8 uger efter afslutning af de første 3 behandlingsforløb.
Inden for 4-8 uger efter pancreatektomi får patienterne yderligere 3 behandlinger med oxaliplatin, irinotecanhydrochlorid og fluorouracil i fravær af sygdomsprogression eller uacceptabel toksicitet.
|
Givet IV
Andre navne:
Givet IV
Andre navne:
Givet IV
Andre navne:
Gennemgå pancreatektomi
Andre navne:
|
|
Eksperimentel: Arm II (gemcitabin, nab-paclitaxel og kirurgi)
Patienter modtager paclitaxel albumin-stabiliseret nanopartikelformulering IV over 30 minutter og gemcitabinhydrochlorid IV over 30 minutter på dag 1, 8 og 15.
Behandlingen gentages hver 28. dag i 3 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.
Patienter, der opnår stabil sygdom eller bedre, gennemgår pancreatektomi 4-8 uger efter afslutning af de første 3 behandlingsforløb.
Inden for 4-8 uger efter pancreatektomi får patienterne yderligere 3 forløb med paclitaxel albumin-stabiliseret nanopartikelformulering og gemcitabinhydrochloridbehandling i fravær af sygdomsprogression eller uacceptabel toksicitet.
|
Givet IV
Andre navne:
Givet IV
Andre navne:
Gennemgå pancreatektomi
Andre navne:
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Samlet overlevelse (OS)
Tidsramme: Op til 4 år for estimater af median samlet overlevelse. Op til 2 år for statistisk analyse 1 og 2, der sammenligner den observerede 2-årige samlede overlevelse (OS) med nulhypotesen på 40 %, i hver arm.
|
OS er længden af tid mellem protokolregistrering og patientens død
|
Op til 4 år for estimater af median samlet overlevelse. Op til 2 år for statistisk analyse 1 og 2, der sammenligner den observerede 2-årige samlede overlevelse (OS) med nulhypotesen på 40 %, i hver arm.
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Antal patienter med grad 3 til grad 5 bivirkninger, der er relateret til undersøgelsesmedicin
Tidsramme: Behandlingsvarighed og opfølgning indtil død eller 4 år efter registrering.
|
Kun uønskede hændelser, der muligvis, sandsynligvis eller helt sikkert er relateret til præoperativ og postoperativ kemoterapi, er rapporteret.
|
Behandlingsvarighed og opfølgning indtil død eller 4 år efter registrering.
|
|
Antal patienter, der skal til operation for resektion efter præoperativ kemoterapi.
Tidsramme: Op til 8 måneder efter registrering (og inden for 4 til 8 uger efter den sidste dosis af cyklus 3 præoperativ kemoterapi).
|
Op til 8 måneder efter registrering (og inden for 4 til 8 uger efter den sidste dosis af cyklus 3 præoperativ kemoterapi).
|
|
|
Antal patienter, der opnår R0-resektion efter præoperativ kemoterapi.
Tidsramme: Op til 8 måneder efter registrering (og inden for 4 til 8 uger efter den sidste dosis af cyklus 3 præoperativ kemoterapi).
|
R0-resektionsklassificering er defineret som makroskopisk fuldstændig tumorfjernelse med negative mikroskopiske kirurgiske marginer (galdegang, pancreas-parenkym og mesenteriske arteriemargener).
|
Op til 8 måneder efter registrering (og inden for 4 til 8 uger efter den sidste dosis af cyklus 3 præoperativ kemoterapi).
|
|
Antal deltagere med respons efter præoperativ kemoterapi, inklusive bekræftet og ubekræftet, fuldstændig og delvis respons, pr. RECIST 1.1.
Tidsramme: Op til 6 måneder efter registrering (og inden for 2 til 4 uger efter den sidste dosis af cyklus 3 præoperativ kemoterapi).
|
Evalueringskriterier pr. respons i solide tumorer (RECIST v1.1) for mållæsioner og vurderet ved MR: Komplet respons (CR), forsvinden af alle mållæsioner; Delvis respons (PR), >=30 % fald i summen af den længste diameter af mållæsioner; Samlet respons (OR) = CR + PR.
|
Op til 6 måneder efter registrering (og inden for 2 til 4 uger efter den sidste dosis af cyklus 3 præoperativ kemoterapi).
|
|
Antal deltagere med fuldstændig respons, moderat respons, minimal respons og dårlig eller ingen respons efter resektion.
Tidsramme: Op til 8 måneder efter registrering (og inden for 4 til 8 uger efter den sidste dosis af cyklus 3 præoperativ kemoterapi).
|
Patologisk respons blev evalueret, efter at patienten var blevet opereret, og var baseret på lokal patologigennemgang af den resekerede kirurgiske prøve i henhold til følgende definitioner af tumorregressionsgrad: 0: Komplet respons - ingen resterende tumor
|
Op til 8 måneder efter registrering (og inden for 4 til 8 uger efter den sidste dosis af cyklus 3 præoperativ kemoterapi).
|
|
Antal deltagere med lokoregionalt og fjernt tilbagefald efter R0 eller R1 resektion.
Tidsramme: Op til 4 år
|
Loko-regionalt recidiv defineres som ethvert tegn på ny sygdom i bugspytkirtlens tumorleje baseret på overvågningsscanninger. Bugspytkirteltumorsengen inkluderer:
Fjernt tilbagefald defineres som ethvert tegn på ny sygdom uden for den primære tumorleje (lever, lunger osv.) baseret på overvågningsscanninger. |
Op til 4 år
|
|
Sygdomsfri overlevelse fra tidspunktet for R0 eller R1 resektion.
Tidsramme: Op til 4 år
|
Sygdomsfri overlevelse (DFS) beregnes for patienter, der gennemgår kirurgisk resektion (R0/R1).
DFS vil blive målt fra datoen for kirurgisk resektion til datoen for første dokumentation for recidiv (lokalregionalt eller fjernt) eller død på grund af en hvilken som helst årsag.
Patienter, der sidst er kendt for at være i live og fri for sygdom, vil blive censureret på datoen for sidste kontakt.
|
Op til 4 år
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Davendra Sohal, Southwest Oncology Group
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Sohal DPS, Duong M, Ahmad SA, Gandhi NS, Beg MS, Wang-Gillam A, Wade JL 3rd, Chiorean EG, Guthrie KA, Lowy AM, Philip PA, Hochster HS. Efficacy of Perioperative Chemotherapy for Resectable Pancreatic Adenocarcinoma: A Phase 2 Randomized Clinical Trial. JAMA Oncol. 2021 Mar 1;7(3):421-427. doi: 10.1001/jamaoncol.2020.7328. Erratum In: JAMA Oncol. 2021 Sep 23;:null.
- Ahmad SA, Duong M, Sohal DPS, Gandhi NS, Beg MS, Wang-Gillam A, Wade JL 3rd, Chiorean EG, Guthrie KA, Lowy AM, Philip PA, Hochster HS. Surgical Outcome Results From SWOG S1505: A Randomized Clinical Trial of mFOLFIRINOX Versus Gemcitabine/Nab-paclitaxel for Perioperative Treatment of Resectable Pancreatic Ductal Adenocarcinoma. Ann Surg. 2020 Sep 1;272(3):481-486. doi: 10.1097/SLA.0000000000004155.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
6. januar 2016
Primær færdiggørelse (Faktiske)
31. maj 2020
Studieafslutning (Faktiske)
26. september 2022
Datoer for studieregistrering
Først indsendt
25. september 2015
Først indsendt, der opfyldte QC-kriterier
25. september 2015
Først opslået (Skøn)
29. september 2015
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
19. oktober 2022
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
18. oktober 2022
Sidst verificeret
1. oktober 2022
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Sygdomme i fordøjelsessystemet
- Neoplasmer efter histologisk type
- Neoplasmer
- Neoplasmer efter sted
- Karcinom
- Neoplasmer, kirtel og epitel
- Sygdomme i det endokrine system
- Neoplasmer i fordøjelsessystemet
- Neoplasmer i endokrine kirtler
- Pancreassygdomme
- Adenocarcinom
- Bugspytkirtel neoplasmer
- Lægemidlers fysiologiske virkninger
- Molekylære mekanismer for farmakologisk virkning
- Anti-infektionsmidler
- Antivirale midler
- Enzymhæmmere
- Antimetabolitter, Antineoplastisk
- Antimetabolitter
- Antineoplastiske midler
- Immunsuppressive midler
- Immunologiske faktorer
- Tubulin modulatorer
- Antimitotiske midler
- Mitose modulatorer
- Gastrointestinale midler
- Antineoplastiske midler, fytogene
- Topoisomerasehæmmere
- Topoisomerase I-hæmmere
- Gemcitabin
- Paclitaxel
- Fluorouracil
- Oxaliplatin
- Irinotecan
- Albumin-bundet Paclitaxel
- Pancrelipase
- Camptothecin
- Pancreatin
Andre undersøgelses-id-numre
- S1505 (Anden identifikator: CTEP)
- U10CA180888 (U.S. NIH-bevilling/kontrakt)
- NCI-2015-01236 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .