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Pegyleret liposomalt doxorubicinhydrochlorid med atezolizumab og/eller bevacizumab til behandling af patienter med tilbagevendende kræft i æggestokkene, æggelederen eller primær peritoneal cancer

29. maj 2026 opdateret af: National Cancer Institute (NCI)

Et randomiseret, fase II/III-studie af pegyleret liposomalt doxorubicin og CTEP-leveret atezolizumab versus pegyleret liposomalt doxorubicin, CTEP-leveret bevacizumab og CTEP-leveret atezolizumab versus pegyleret liposomalt liposomalt doxorubicin og CTEP-leveret bevacizumab og CTEP-leveret

Dette fase II/III-studie undersøger, hvor godt pegyleret liposomalt doxorubicinhydrochlorid med atezolizumab og/eller bevacizumab virker ved behandling af patienter med ovarie-, æggeleder- eller primær peritonealcancer, der er vendt tilbage (tilbagevendende). Kemoterapi-lægemidler, såsom pegyleret liposomalt doxorubicinhydrochlorid, virker på forskellige måder for at stoppe væksten af tumorceller, enten ved at dræbe cellerne, ved at stoppe dem i at dele sig eller ved at stoppe dem i at sprede sig. Immunterapi med monoklonale antistoffer, såsom atezolizumab, kan hjælpe kroppens immunsystem med at angribe kræften og kan forstyrre tumorcellernes evne til at vokse og sprede sig. Bevacizumab er et monoklonalt antistof, der kan forstyrre tumorcellernes evne til at vokse og sprede sig. Det vides endnu ikke, hvilken kombination der vil fungere bedre ved behandling af patienter med kræft i æggestokkene, æggelederen eller primær peritonealcancer.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆRE MÅL:

I. Estimer sandsynligheden for en dosisbegrænsende toksicitet (DLT) efter cyklus 1 af eksperimentelle regimer (pegyleret liposomal doxorubicin hydrochlorid [pegyleret liposomal doxorubicin] [PLD] og atezolizumab og PLD/bevacizumab og atezolizumab). (Sikkerhedsindføring) II. Estimer og sammenlign risikoen for første progression eller død (progressionsfri overlevelse [PFS]) for hvert forsøgsregime i forhold til referenceregimet, PLD og bevacizumab. (Fase II undersøgelse) III. Estimer og sammenlign risikoen for død og faren for første progression eller død (PFS) af det eksperimentelle regime i forhold til referenceregimet. (Fase III) (24-FEB-2021)

SEKUNDÆRE MÅL:

I. Estimer og sammenlign sandsynligheden for respons (objektiv responsrate [ORR], enten delvis eller fuldstændig respons) defineret af responsevalueringskriterier i solide tumorer (RECIST) version (v)1.1-kriterier for hvert undersøgelsesregime. (Fase II undersøgelse) (24-FEB-2021) II. Estimer hyppigheden og sværhedsgraden af bivirkninger som klassificeret og klassificeret med Common Terminology Criteria for Adverse Events (CTCAE) hos de patienter, der starter deres tilfældigt tildelte undersøgelsesbehandling. (Fase II undersøgelse) (19.03.2018) III. Estimer og sammenlign ORR i hver behandlingsgruppe. (Fase III undersøgelse) IV. Estimer hyppigheden og sværhedsgraden af bivirkninger hos de patienter, der påbegynder deres tilfældigt tildelte undersøgelsesbehandling. (Fase III-studie) V. Estimer og sammenlign gennemsnitlige patientrapporterede udfaldsscore (PRO'er) som målt af National Comprehensive Cancer Network (NCCN)-Functional Assessment of Cancer Therapy (FACT) ovariesymptomindeks (NFOSI)-18 sygdomsrelaterede symptomer ( DRS). (Fase III undersøgelse) VI. Estimer og sammenlign behandlingsgrupperne på baggrund af PRO'erne: behandlingsbivirkninger (TSE), funktion/velvære (FWB), træthed (Functional Assessment of Chronic Illness Therapy [FACIT]-fatigue subscale) og abdominalt ubehag (FACT/ Gynækologisk onkologisk gruppe [GOG]-abdominalt ubehag [AD] subskala). (Fase III undersøgelse) (16/10/2017)

OVERSÆTTELSESVidenskabelige MÅL:

I. At bestemme, om biomarkørniveauer i præ-behandlingsvæv og præ- eller under-behandling perifert blod og afføringsprøver er forbundet med ORR, PFS og/eller total overlevelse (OS).

II. Estimer præ-behandling PD-L1 ekspression på tumorceller målt ved kvantitativ immunhistokemi (IHC), og bestem, om det er forbundet med varigheden af PFS eller den samlede overlevelse. (Integreret biomarkør) III. Analyse af T-cellereceptor (TCR) repertoirer ved dyb sekventering af perifere blodprøver. (Exploratory Biomarkers [10/16/2017]) IV. Tumor-"immunogenicitet" som bestemt af neo-antigen-landskabet og karakterisering af tumormikromiljøet ved hjælp af næste generations sekventering, herunder, men ikke begrænset til, hel exom-sekventering og/eller RNA-sekventering. (Exploratory Biomarkers [10/16/2017]) V. Mikrobiom analyse via afføringsprøvetagning. (Exploratory Biomarkers [10/16/2017]) VI. For at bestemme, om ændringer i kvantitative biomarkørparametre efter de første 6 og 12 ugers behandling forudsiger ORR, PFS og/eller OS.

OVERSIGT: Patienterne vil blive randomiseret til 1 ud af 3 arme.

ARM I: Patienter får pegyleret liposomalt doxorubicinhydrochlorid intravenøst (IV) over 60 minutter på dag 1 og atezolizumab IV over 30-60 minutter på dag 1 og 15. (Lukket for optjening pr. 9. februar 2021)

ARM II: Patienter får pegyleret liposomalt doxorubicinhydrochlorid IV over 60 minutter på dag 1, bevacizumab IV over 30-90 minutter på dag 1 og 15 og atezolizumab IV over 30-60 minutter på dag 1 og 15. Patienter gennemgår også computertomografi (CT) ved undersøgelse.

ARM III: Patienter får pegyleret liposomalt doxorubicinhydrochlorid IV over 60 minutter på dag 1 og bevacizumab IV over 30-90 minutter på dag 1 og 15. Patienterne gennemgår også CT ved undersøgelse.

I alle arme gentages cyklusser hver 28. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.

Efter afsluttet undersøgelsesbehandling følges patienterne hver 3. måned i op til 2 år og derefter hver 6. måned i op til 3 år.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

444

Fase

Fase 2
Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Forenede Stater
- Alaska
  - Anchorage, Alaska, Forenede Stater, 98508
    - Anchorage Associates in Radiation Medicine
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Oncology and Hematology LLC
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Women's Cancer Care
  - Anchorage, Alaska, Forenede Stater, 99508
    - Anchorage Oncology Centre
  - Anchorage, Alaska, Forenede Stater, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, Forenede Stater, 99508
    - Providence Alaska Medical Center
  - Anchorage, Alaska, Forenede Stater, 99504
    - Anchorage Radiation Therapy Center
  - Fairbanks, Alaska, Forenede Stater, 99701
    - Fairbanks Memorial Hospital
- Arizona
  - Goodyear, Arizona, Forenede Stater, 85338
    - CTCA at Western Regional Medical Center
  - Kingman, Arizona, Forenede Stater, 86401
    - Kingman Regional Medical Center
  - Phoenix, Arizona, Forenede Stater, 85004
    - Cancer Center at Saint Joseph's
  - Tucson, Arizona, Forenede Stater, 85719
    - Banner University Medical Center - Tucson
- Arkansas
  - Fort Smith, Arkansas, Forenede Stater, 72903
    - Mercy Hospital Fort Smith
  - Hot Springs, Arkansas, Forenede Stater, 71913
    - CHI Saint Vincent Cancer Center Hot Springs
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    - University of Arkansas for Medical Sciences
- California
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    - PCR Oncology
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    - Mission Hope Medical Oncology - Arroyo Grande
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    - Mercy San Juan Medical Center
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    - Community Cancer Institute
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    - University Oncology Associates
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    - Mercy Cancer Center - Elk Grove
  - Emeryville, California, Forenede Stater, 94608
    - Bay Area Breast Surgeons Inc
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    - Epic Care Partners in Cancer Care
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    - Kaiser Permanente-Fontana
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    - Kaiser Permanente-Fremont
  - Fremont, California, Forenede Stater, 94538
    - Palo Alto Medical Foundation-Fremont
  - Fresno, California, Forenede Stater, 93720
    - Kaiser Permanente-Fresno
  - Fresno, California, Forenede Stater, 93720
    - Fresno Cancer Center
  - Greenbrae, California, Forenede Stater, 94904
    - Marin Cancer Care Inc
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    - Marin General Hospital
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    - Kaiser Permanente South Bay
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    - Kaiser Permanente-Irvine
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    - Loma Linda University Medical Center
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    - Kaiser Permanente Los Angeles Medical Center
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    - Contra Costa Regional Medical Center
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    - Memorial Medical Center
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    - Kaiser Permanente-Modesto
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    - Palo Alto Medical Foundation-Gynecologic Oncology
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    - Kaiser Permanente-Oakland
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    - Alta Bates Summit Medical Center - Summit Campus
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    - Bay Area Tumor Institute
  - Ontario, California, Forenede Stater, 91761
    - Kaiser Permanente-Ontario
  - Orange, California, Forenede Stater, 92868
    - UC Irvine Health/Chao Family Comprehensive Cancer Center
  - Palo Alto, California, Forenede Stater, 94301
    - Palo Alto Medical Foundation Health Care
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    - Kaiser Permanente - Panorama City
  - Rancho Cordova, California, Forenede Stater, 95670
    - Kaiser Permanente-Rancho Cordova Cancer Center
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    - Eisenhower Medical Center
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    - Kaiser Permanente-Redwood City
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    - Kaiser Permanente- Marshall Medical Offices
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    - Kaiser Permanente-Richmond
  - Riverside, California, Forenede Stater, 92505
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  - Rocklin, California, Forenede Stater, 95765
    - Mercy Cancer Center - Rocklin
  - Rohnert Park, California, Forenede Stater, 94928
    - Rohnert Park Cancer Center
  - Roseville, California, Forenede Stater, 95678
    - The Permanente Medical Group-Roseville Radiation Oncology
  - Roseville, California, Forenede Stater, 95661
    - Kaiser Permanente-Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Cancer Centers Radiation Oncology Services-Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forenede Stater, 95816
    - Sutter Medical Center Sacramento
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    - South Sacramento Cancer Center
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    - Kaiser Permanente Sacramento Medical Center
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    - Mercy Cancer Center - Sacramento
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    - UCSF Medical Center-Mission Bay
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    - California Pacific Medical Center-Pacific Campus
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    - Kaiser Permanente-Santa Teresa-San Jose
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    - Pacific Central Coast Health Center-San Luis Obispo
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    - Kaiser San Rafael-Gallinas
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    - Kaiser Permanente-San Rafael
  - Santa Clara, California, Forenede Stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Cruz, California, Forenede Stater, 95065
    - Palo Alto Medical Foundation-Santa Cruz
  - Santa Maria, California, Forenede Stater, 93444
    - Mission Hope Medical Oncology - Santa Maria
  - Santa Rosa, California, Forenede Stater, 95403
    - Kaiser Permanente-Santa Rosa
  - Santa Rosa, California, Forenede Stater, 95403
    - Sutter Pacific Medical Foundation
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente Cancer Treatment Center
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente-South San Francisco
  - Stockton, California, Forenede Stater, 95210
    - Kaiser Permanente-Stockton
  - Sunnyvale, California, Forenede Stater, 94086
    - Palo Alto Medical Foundation-Sunnyvale
  - Vacaville, California, Forenede Stater, 95688
    - Kaiser Permanente Medical Center-Vacaville
  - Vacaville, California, Forenede Stater, 95687
    - Northbay Cancer Center
  - Vallejo, California, Forenede Stater, 94589
    - Kaiser Permanente-Vallejo
  - Vallejo, California, Forenede Stater, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek, California, Forenede Stater, 94596
    - Kaiser Permanente-Walnut Creek
  - Walnut Creek, California, Forenede Stater, 94598
    - John Muir Medical Center-Walnut Creek
  - Walnut Creek, California, Forenede Stater, 94597
    - Epic Care Cyberknife Center
  - Woodland, California, Forenede Stater, 95695
    - Woodland Memorial Hospital
  - Woodland Hills, California, Forenede Stater, 91367
    - Kaiser Permanente-Woodland Hills
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Forenede Stater, 80012
    - The Medical Center of Aurora
  - Aurora, Colorado, Forenede Stater, 80045
    - UCHealth University of Colorado Hospital
  - Boulder, Colorado, Forenede Stater, 80303
    - Boulder Community Foothills Hospital
  - Boulder, Colorado, Forenede Stater, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Centennial, Colorado, Forenede Stater, 80112
    - Rocky Mountain Cancer Centers - Centennial
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Rocky Mountain Cancer Centers-Penrose
  - Colorado Springs, Colorado, Forenede Stater, 80923
    - Saint Francis Cancer Center
  - Denver, Colorado, Forenede Stater, 80205
    - Kaiser Permanente-Franklin
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Forenede Stater, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Forenede Stater, 80204
    - Denver Health Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Forenede Stater, 80204
    - Cancer Center of Colorado at Sloan's Lake
  - Denver, Colorado, Forenede Stater, 80209
    - The Women's Imaging Center
  - Denver, Colorado, Forenede Stater, 80206
    - National Jewish Health-Main Campus
  - Denver, Colorado, Forenede Stater, 80220
    - Western Surgical Care
  - Denver, Colorado, Forenede Stater, 80218
    - Saint Joseph Hospital - Cancer Centers of Colorado
  - Denver, Colorado, Forenede Stater, 80210
    - AdventHealth Porter
  - Durango, Colorado, Forenede Stater, 81301
    - Mercy Medical Center
  - Durango, Colorado, Forenede Stater, 81301
    - CommonSpirit Cancer Center Mercy
  - Englewood, Colorado, Forenede Stater, 80113
    - Mountain Blue Cancer Care Center - Swedish
  - Englewood, Colorado, Forenede Stater, 80113
    - Swedish Medical Center
  - Englewood, Colorado, Forenede Stater, 80113
    - Rocky Mountain Cancer Centers - Swedish
  - Englewood, Colorado, Forenede Stater, 80113
    - The Melanoma and Skin Cancer Institute
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Golden, Colorado, Forenede Stater, 80401
    - Mountain Blue Cancer Care Center
  - Golden, Colorado, Forenede Stater, 80401
    - National Jewish Health-Western Hematology Oncology
  - Grand Junction, Colorado, Forenede Stater, 81501
    - Saint Mary's Hospital and Regional Medical Center
  - Greeley, Colorado, Forenede Stater, 80631
    - Banner North Colorado Medical Center
  - Lafayette, Colorado, Forenede Stater, 80026
    - Kaiser Permanente-Rock Creek
  - Lafayette, Colorado, Forenede Stater, 80026
    - Good Samaritan Hospital - Cancer Centers of Colorado
  - Lakewood, Colorado, Forenede Stater, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Lakewood, Colorado, Forenede Stater, 80228
    - CommonSpirit Saint Anthony Hospital Cancer Center
  - Littleton, Colorado, Forenede Stater, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton, Colorado, Forenede Stater, 80122
    - AdventHealth Littleton
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Kaiser Permanente-Lone Tree
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Longmont, Colorado, Forenede Stater, 80501
    - Longmont United Hospital
  - Longmont, Colorado, Forenede Stater, 80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland, Colorado, Forenede Stater, 80539
    - Banner North Colorado Medical Center - Loveland Campus
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    - Rocky Mountain Cancer Centers-Parker
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    - AdventHealth Parker
  - Pueblo, Colorado, Forenede Stater, 81004
    - Saint Mary Corwin Medical Center
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    - Rocky Mountain Cancer Centers - Pueblo
  - Thornton, Colorado, Forenede Stater, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Thornton, Colorado, Forenede Stater, 80260
    - National Jewish Health-Northern Hematology Oncology
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- Delaware
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    - Helen F Graham Cancer Center
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    - Delaware Clinical and Laboratory Physicians PA
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    - Medical Oncology Hematology Consultants PA
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- District of Columbia
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    - Kaiser Permanente-Capitol Hill Medical Center
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    - Sibley Memorial Hospital
- Florida
  - Aventura, Florida, Forenede Stater, 33180
    - Mount Sinai Comprehensive Cancer Center at Aventura
  - Fort Lauderdale, Florida, Forenede Stater, 33308
    - Holy Cross Hospital
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    - Mount Sinai Medical Center
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    - Sacred Heart Hospital
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    - Sarasota Memorial Hospital
- Georgia
  - Atlanta, Georgia, Forenede Stater, 30308
    - Emory University Hospital Midtown
  - Atlanta, Georgia, Forenede Stater, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, Forenede Stater, 30342
    - Emory Saint Joseph's Hospital
  - Atlanta, Georgia, Forenede Stater, 30342
    - Northside Hospital
  - Augusta, Georgia, Forenede Stater, 30912
    - Augusta University Medical Center
  - Braselton, Georgia, Forenede Stater, 30517
    - Northeast Georgia Medical Center Braselton
  - Cumming, Georgia, Forenede Stater, 30041
    - Northside Hospital-Forsyth
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    - Emory Decatur Hospital
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    - Northeast Georgia Medical Center-Gainesville
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    - CTCA at Southeastern Regional Medical Center
  - Savannah, Georgia, Forenede Stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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    - Memorial Health University Medical Center
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    - Summit Cancer Care-Memorial
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    - Summit Cancer Care-Candler
  - Savannah, Georgia, Forenede Stater, 31404
    - Low Country Cancer Care
- Hawaii
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Medical Center
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    - The Cancer Center of Hawaii-Liliha
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    - Hawaii Cancer Care Inc - Waterfront Plaza
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Cancer Cenrer - POB I
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forenede Stater, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Hawaii Cancer Care Inc-Liliha
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Kuakini Medical Center
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    - Queen's Cancer Center - Kuakini
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    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Island Urology
  - Honolulu, Hawaii, Forenede Stater, 96819
    - Kaiser Permanente Moanalua Medical Center
  - Lihue, Hawaii, Forenede Stater, 96766
    - Wilcox Memorial Hospital and Kauai Medical Clinic
  - ‘Aiea, Hawaii, Forenede Stater, 96701
    - Hawaii Cancer Care - Westridge
  - ‘Aiea, Hawaii, Forenede Stater, 96701
    - Pali Momi Medical Center
  - ‘Aiea, Hawaii, Forenede Stater, 96701
    - Queen's Cancer Center - Pearlridge
  - ‘Aiea, Hawaii, Forenede Stater, 96701
    - The Cancer Center of Hawaii-Pali Momi
- Idaho
  - Boise, Idaho, Forenede Stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Forenede Stater, 83712
    - Saint Luke's Cancer Institute - Boise
  - Caldwell, Idaho, Forenede Stater, 83605
    - Saint Alphonsus Cancer Care Center-Caldwell
  - Coeur d'Alene, Idaho, Forenede Stater, 83814
    - Kootenai Health - Coeur d'Alene
  - Emmett, Idaho, Forenede Stater, 83617
    - Walter Knox Memorial Hospital
  - Fruitland, Idaho, Forenede Stater, 83619
    - Saint Luke's Cancer Institute - Fruitland
  - Meridian, Idaho, Forenede Stater, 83642
    - Idaho Urologic Institute-Meridian
  - Meridian, Idaho, Forenede Stater, 83642
    - Saint Luke's Cancer Institute - Meridian
  - Nampa, Idaho, Forenede Stater, 83687
    - Saint Alphonsus Cancer Care Center-Nampa
  - Nampa, Idaho, Forenede Stater, 83687
    - Saint Luke's Cancer Institute - Nampa
  - Post Falls, Idaho, Forenede Stater, 83854
    - Kootenai Clinic Cancer Services - Post Falls
  - Sandpoint, Idaho, Forenede Stater, 83864
    - Kootenai Clinic Cancer Services - Sandpoint
  - Twin Falls, Idaho, Forenede Stater, 83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Alton, Illinois, Forenede Stater, 62002
    - OSF Saint Anthony's Health Center
  - Aurora, Illinois, Forenede Stater, 60504
    - Rush-Copley Medical Center
  - Bloomington, Illinois, Forenede Stater, 61704
    - Illinois CancerCare-Bloomington
  - Canton, Illinois, Forenede Stater, 61520
    - Illinois CancerCare-Canton
  - Carbondale, Illinois, Forenede Stater, 62902
    - Memorial Hospital of Carbondale
  - Carterville, Illinois, Forenede Stater, 62918
    - SIH Cancer Institute
  - Carthage, Illinois, Forenede Stater, 62321
    - Illinois CancerCare-Carthage
  - Centralia, Illinois, Forenede Stater, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Forenede Stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forenede Stater, 60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago, Illinois, Forenede Stater, 60612
    - University of Illinois
  - Chicago, Illinois, Forenede Stater, 60612
    - John H Stroger Jr Hospital of Cook County
  - Chicago, Illinois, Forenede Stater, 60612
    - Rush MD Anderson Cancer Center
  - Danville, Illinois, Forenede Stater, 61832
    - Carle at The Riverfront
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forenede Stater, 62526
    - Cancer Care Specialists of Illinois - Decatur
  - Dixon, Illinois, Forenede Stater, 61021
    - Illinois CancerCare-Dixon
  - Effingham, Illinois, Forenede Stater, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Forenede Stater, 62401
    - Carle Physician Group-Effingham
  - Eureka, Illinois, Forenede Stater, 61530
    - Illinois CancerCare-Eureka
  - Evanston, Illinois, Forenede Stater, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare-Galesburg
  - Geneva, Illinois, Forenede Stater, 60134
    - Northwestern Medicine Cancer Center Delnor
  - Glenview, Illinois, Forenede Stater, 60026
    - NorthShore University HealthSystem-Glenbrook Hospital
  - Highland Park, Illinois, Forenede Stater, 60035
    - NorthShore University HealthSystem-Highland Park Hospital
  - Hinsdale, Illinois, Forenede Stater, 60521
    - Sudarshan K Sharma MD Limited-Gynecologic Oncology
  - Kewanee, Illinois, Forenede Stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Lake Forest, Illinois, Forenede Stater, 60045
    - Northwestern Medicine Lake Forest Hospital
  - Macomb, Illinois, Forenede Stater, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, Forenede Stater, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Maywood, Illinois, Forenede Stater, 60153
    - Loyola University Medical Center
  - Melrose Park, Illinois, Forenede Stater, 60160
    - Marjorie Weinberg Cancer Center at Loyola-Gottlieb
  - Mount Vernon, Illinois, Forenede Stater, 62864
    - SSM Health Good Samaritan
  - New Lenox, Illinois, Forenede Stater, 60451
    - UC Comprehensive Cancer Center at Silver Cross
  - O'Fallon, Illinois, Forenede Stater, 62269
    - Cancer Care Center of O'Fallon
  - Orland Park, Illinois, Forenede Stater, 60462
    - University of Chicago Medicine-Orland Park
  - Ottawa, Illinois, Forenede Stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Pekin, Illinois, Forenede Stater, 61554
    - Illinois CancerCare-Pekin
  - Peoria, Illinois, Forenede Stater, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forenede Stater, 61615
    - Illinois CancerCare-Peoria
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forenede Stater, 61354
    - Valley Radiation Oncology
  - Princeton, Illinois, Forenede Stater, 61356
    - Illinois CancerCare-Princeton
  - Skokie, Illinois, Forenede Stater, 60076
    - North Shore Medical Center
  - Springfield, Illinois, Forenede Stater, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Forenede Stater, 62702
    - Springfield Clinic
  - Springfield, Illinois, Forenede Stater, 62781
    - Springfield Memorial Hospital
  - Swansea, Illinois, Forenede Stater, 62226
    - Southwest Illinois Health Services LLP
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Forenede Stater, 61801
    - The Carle Foundation Hospital
  - Warrenville, Illinois, Forenede Stater, 60555
    - Northwestern Medicine Cancer Center Warrenville
  - Washington, Illinois, Forenede Stater, 61571
    - Illinois CancerCare - Washington
  - Yorkville, Illinois, Forenede Stater, 60560
    - Rush-Copley Healthcare Center
  - Zion, Illinois, Forenede Stater, 60099
    - Midwestern Regional Medical Center
- Indiana
  - Fort Wayne, Indiana, Forenede Stater, 46805
    - Parkview Hospital Randallia
  - Fort Wayne, Indiana, Forenede Stater, 46845
    - Parkview Regional Medical Center
  - Indianapolis, Indiana, Forenede Stater, 46237
    - Franciscan Health Indianapolis
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Forenede Stater, 46260
    - Ascension Saint Vincent Indianapolis Hospital
  - Lafayette, Indiana, Forenede Stater, 47905
    - Franciscan Saint Elizabeth Health - Lafayette East
  - Michigan City, Indiana, Forenede Stater, 46360
    - Woodland Cancer Care Center
  - Mooresville, Indiana, Forenede Stater, 46158
    - Franciscan Health Mooresville
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Health
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - Terre Haute, Indiana, Forenede Stater, 47804
    - Union Hospital
- Iowa
  - Clive, Iowa, Forenede Stater, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, Forenede Stater, 50325
    - UI Health Care Mission Cancer and Blood - West Des Moines Clinic
  - Council Bluffs, Iowa, Forenede Stater, 51503
    - Alegent Health Mercy Hospital
  - Creston, Iowa, Forenede Stater, 50801
    - Greater Regional Medical Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50314
    - UI Health Care Mission Cancer and Blood - Laurel Clinic
  - Iowa City, Iowa, Forenede Stater, 52242
    - University of Iowa/Holden Comprehensive Cancer Center
  - West Des Moines, Iowa, Forenede Stater, 50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Coffeyville, Kansas, Forenede Stater, 67337
    - Coffeyville Regional Medical Center
  - Garden City, Kansas, Forenede Stater, 67846
    - Central Care Cancer Center - Garden City
  - Great Bend, Kansas, Forenede Stater, 67530
    - Central Care Cancer Center - Great Bend
  - Hays, Kansas, Forenede Stater, 67601
    - HaysMed
  - Kansas City, Kansas, Forenede Stater, 66160
    - University of Kansas Cancer Center
  - Lawrence, Kansas, Forenede Stater, 66044
    - Lawrence Memorial Hospital
  - Olathe, Kansas, Forenede Stater, 66061
    - The University of Kansas Cancer Center - Olathe
  - Overland Park, Kansas, Forenede Stater, 66210
    - University of Kansas Cancer Center-Overland Park
  - Overland Park, Kansas, Forenede Stater, 66211
    - University of Kansas Hospital-Indian Creek Campus
  - Pittsburg, Kansas, Forenede Stater, 66762
    - Mercy Hospital Pittsburg
  - Salina, Kansas, Forenede Stater, 67401
    - Salina Regional Health Center
  - Topeka, Kansas, Forenede Stater, 66606
    - University of Kansas Health System Saint Francis Campus
  - Topeka, Kansas, Forenede Stater, 66606
    - Cotton O'Neil Cancer Center / Stormont Vail Health
  - Westwood, Kansas, Forenede Stater, 66205
    - University of Kansas Hospital-Westwood Cancer Center
  - Wichita, Kansas, Forenede Stater, 67208
    - Associates In Womens Health
- Kentucky
  - Bardstown, Kentucky, Forenede Stater, 40004
    - Flaget Memorial Hospital
  - Corbin, Kentucky, Forenede Stater, 40701
    - Baptist Health Corbin
  - Corbin, Kentucky, Forenede Stater, 40701
    - Commonwealth Cancer Center-Corbin
  - Edgewood, Kentucky, Forenede Stater, 41017
    - Saint Elizabeth Healthcare Edgewood
  - Lexington, Kentucky, Forenede Stater, 40504
    - Saint Joseph Radiation Oncology Resource Center
  - Lexington, Kentucky, Forenede Stater, 40509
    - Saint Joseph Hospital East
  - Lexington, Kentucky, Forenede Stater, 40503
    - Baptist Health Lexington
  - London, Kentucky, Forenede Stater, 40741
    - Saint Joseph London
  - Louisville, Kentucky, Forenede Stater, 40202
    - Norton Hospital Pavilion and Medical Campus
  - Louisville, Kentucky, Forenede Stater, 40241
    - Norton Brownsboro Hospital and Medical Campus
  - Louisville, Kentucky, Forenede Stater, 40202
    - Jewish Hospital
  - Louisville, Kentucky, Forenede Stater, 40207
    - Norton Suburban Hospital and Medical Campus
  - Louisville, Kentucky, Forenede Stater, 40245
    - UofL Health Medical Center Northeast
  - Louisville, Kentucky, Forenede Stater, 40207
    - Baptist Health Louisville
  - Louisville, Kentucky, Forenede Stater, 40215
    - Saints Mary and Elizabeth Hospital
  - Madisonville, Kentucky, Forenede Stater, 42431
    - Baptist Health Madisonville/Merle Mahr Cancer Center
  - Paducah, Kentucky, Forenede Stater, 42003
    - Baptist Health Paducah
  - Shepherdsville, Kentucky, Forenede Stater, 40165
    - Jewish Hospital Medical Center South
- Louisiana
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Forenede Stater, 70816
    - Medical Center of Baton Rouge
  - Baton Rouge, Louisiana, Forenede Stater, 70836
    - Ochsner High Grove
  - Baton Rouge, Louisiana, Forenede Stater, 70806
    - Baton Rouge General Medical Center
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Hematology/Oncology Clinic PLLC
  - Covington, Louisiana, Forenede Stater, 70433
    - Women's Cancer Care-Covington
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Tulane University School of Medicine
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Medical Center Jefferson
  - New Orleans, Louisiana, Forenede Stater, 70115
    - Ochsner Baptist Medical Center
- Maine
  - Bangor, Maine, Forenede Stater, 04401
    - Eastern Maine Medical Center
  - Brewer, Maine, Forenede Stater, 04412
    - Lafayette Family Cancer Center-EMMC
  - Scarborough, Maine, Forenede Stater, 04074
    - MaineHealth Maine Medical Center- Scarborough
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21204
    - Greater Baltimore Medical Center
  - Baltimore, Maryland, Forenede Stater, 21244
    - Kaiser Permanente-Woodlawn Medical Center
  - Easton, Maryland, Forenede Stater, 21601
    - University of Maryland Shore Medical Center at Easton
  - Gaithersburg, Maryland, Forenede Stater, 20879
    - Kaiser Permanente-Gaithersburg Medical Center
  - Kensington, Maryland, Forenede Stater, 20895
    - Kaiser Permanente - Kensington Medical Center
  - Largo, Maryland, Forenede Stater, 20774
    - Kaiser Permanente - Largo Medical Center
- Massachusetts
  - Burlington, Massachusetts, Forenede Stater, 01805
    - Lahey Hospital and Medical Center
  - Peabody, Massachusetts, Forenede Stater, 01960
    - Lahey Medical Center-Peabody
  - Springfield, Massachusetts, Forenede Stater, 01199
    - Baystate Medical Center
  - Winchester, Massachusetts, Forenede Stater, 01890
    - Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care
  - Worcester, Massachusetts, Forenede Stater, 01605
    - UMass Memorial Medical Center - Memorial Division
- Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48109
    - University of Michigan Rogel Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - Trinity Health Saint Joseph Mercy Hospital Ann Arbor
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Bronson Battle Creek
  - Brighton, Michigan, Forenede Stater, 48114
    - Trinity Health IHA Medical Group Hematology Oncology - Brighton
  - Brighton, Michigan, Forenede Stater, 48114
    - Trinity Health Medical Center - Brighton
  - Brownstown, Michigan, Forenede Stater, 48183
    - Henry Ford Cancer Institute-Downriver
  - Canton, Michigan, Forenede Stater, 48188
    - Trinity Health IHA Medical Group Hematology Oncology - Canton
  - Canton, Michigan, Forenede Stater, 48188
    - Trinity Health Medical Center - Canton
  - Caro, Michigan, Forenede Stater, 48723
    - Caro Cancer Center
  - Chelsea, Michigan, Forenede Stater, 48118
    - Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
  - Chelsea, Michigan, Forenede Stater, 48118
    - Chelsea Hospital
  - Clarkston, Michigan, Forenede Stater, 48346
    - Hematology Oncology Consultants-Clarkston
  - Clarkston, Michigan, Forenede Stater, 48346
    - Newland Medical Associates-Clarkston
  - Clinton Township, Michigan, Forenede Stater, 48038
    - Henry Ford Macomb Hospital-Clinton Township
  - Dearborn, Michigan, Forenede Stater, 48126
    - Henry Ford Medical Center-Fairlane
  - Detroit, Michigan, Forenede Stater, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Forenede Stater, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Detroit, Michigan, Forenede Stater, 48236
    - Henry Ford Health Saint John Hospital
  - East China Township, Michigan, Forenede Stater, 48054
    - Henry Ford River District Hospital
  - Farmington Hills, Michigan, Forenede Stater, 48334
    - Weisberg Cancer Treatment Center
  - Flint, Michigan, Forenede Stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesee Hematology Oncology PC
  - Flint, Michigan, Forenede Stater, 48503
    - Genesys Hurley Cancer Institute
  - Flint, Michigan, Forenede Stater, 48503
    - Cancer Hematology Centers - Flint
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Trinity Health Grand Rapids Hospital
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Corewell Health Grand Rapids Hospitals - Butterworth Hospital
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Henry Ford Saint John Hospital - Academic
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Henry Ford Saint John Hospital - Breast
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Henry Ford Saint John Hospital - Van Elslander
  - Jackson, Michigan, Forenede Stater, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49009
    - Beacon Kalamazoo Cancer Center
  - Kalamazoo, Michigan, Forenede Stater, 49048
    - Beacon Kalamazoo
  - Lansing, Michigan, Forenede Stater, 48912
    - University of Michigan Health - Sparrow Lansing
  - Livonia, Michigan, Forenede Stater, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Livonia, Michigan, Forenede Stater, 48154
    - Hope Cancer Clinic
  - Macomb, Michigan, Forenede Stater, 48044
    - Henry Ford Warren Hospital - Breast Macomb
  - Macomb, Michigan, Forenede Stater, 48044
    - Henry Ford Saint John Hospital - Macomb Medical
  - Marlette, Michigan, Forenede Stater, 48453
    - Saint Mary's Oncology/Hematology Associates of Marlette
  - Muskegon, Michigan, Forenede Stater, 49444
    - Trinity Health Muskegon Hospital
  - Niles, Michigan, Forenede Stater, 49120
    - Corewell Health Lakeland Hospitals - Niles Hospital
  - Norton Shores, Michigan, Forenede Stater, 49444
    - Cancer and Hematology Centers of Western Michigan - Norton Shores
  - Novi, Michigan, Forenede Stater, 48377
    - Henry Ford Medical Center-Columbus
  - Pontiac, Michigan, Forenede Stater, 48341
    - Hope Cancer Center
  - Pontiac, Michigan, Forenede Stater, 48341
    - Newland Medical Associates-Pontiac
  - Pontiac, Michigan, Forenede Stater, 48341
    - Trinity Health Saint Joseph Mercy Oakland Hospital
  - Pontiac, Michigan, Forenede Stater, 48341
    - Michigan Healthcare Professionals Pontiac
  - Port Huron, Michigan, Forenede Stater, 48060
    - Lake Huron Medical Center
  - Port Huron, Michigan, Forenede Stater, 48060
    - Huron Medical Center PC
  - Reed City, Michigan, Forenede Stater, 49677
    - Corewell Health Reed City Hospital
  - Saginaw, Michigan, Forenede Stater, 48604
    - Oncology Hematology Associates of Saginaw Valley PC
  - Saginaw, Michigan, Forenede Stater, 48601
    - MyMichigan Medical Center Saginaw
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Corewell Health Lakeland Hospitals - Saint Joseph Hospital
  - Shelby, Michigan, Forenede Stater, 48315
    - Henry Ford Macomb Health Center - Shelby Township
  - Sterling Heights, Michigan, Forenede Stater, 48312
    - Bhadresh Nayak MD PC-Sterling Heights
  - Tawas City, Michigan, Forenede Stater, 48764
    - MyMichigan Medical Center Tawas
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
  - Warren, Michigan, Forenede Stater, 48088
    - Advanced Breast Care Center PLLC
  - Warren, Michigan, Forenede Stater, 48093
    - Macomb Hematology Oncology PC
  - Warren, Michigan, Forenede Stater, 48093
    - Henry Ford Madison Heights Hospital - Breast
  - Warren, Michigan, Forenede Stater, 48093
    - Henry Ford Health Warren Hospital
  - Warren, Michigan, Forenede Stater, 48093
    - Henry Ford Warren Hospital - GLCMS
  - West Bloomfield, Michigan, Forenede Stater, 48322
    - Henry Ford West Bloomfield Hospital
  - West Branch, Michigan, Forenede Stater, 48661
    - Saint Mary's Oncology/Hematology Associates of West Branch
  - Wyoming, Michigan, Forenede Stater, 49519
    - University of Michigan Health - West
  - Ypsilanti, Michigan, Forenede Stater, 48197
    - Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
  - Ypsilanti, Michigan, Forenede Stater, 48106
    - Huron Gastroenterology PC
- Minnesota
  - Bemidji, Minnesota, Forenede Stater, 56601
    - Sanford Joe Lueken Cancer Center
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Minnesota Oncology - Burnsville
  - Cambridge, Minnesota, Forenede Stater, 55008
    - Cambridge Medical Center
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy Hospital
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview Southdale Hospital
  - Fridley, Minnesota, Forenede Stater, 55432
    - Unity Hospital
  - Maple Grove, Minnesota, Forenede Stater, 55369
    - Fairview Clinics and Surgery Center Maple Grove
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55454
    - Health Partners Inc
  - Monticello, Minnesota, Forenede Stater, 55362
    - Monticello Cancer Center
  - New Ulm, Minnesota, Forenede Stater, 56073
    - New Ulm Medical Center
  - Princeton, Minnesota, Forenede Stater, 55371
    - Fairview Northland Medical Center
  - Robbinsdale, Minnesota, Forenede Stater, 55422
    - North Memorial Medical Health Center
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Shakopee, Minnesota, Forenede Stater, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Forenede Stater, 55082
    - Lakeview Hospital
  - Thief River Falls, Minnesota, Forenede Stater, 56701
    - Sanford Thief River Falls Medical Center
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forenede Stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Worthington, Minnesota, Forenede Stater, 56187
    - Sanford Cancer Center Worthington
  - Wyoming, Minnesota, Forenede Stater, 55092
    - Fairview Lakes Medical Center
- Mississippi
  - Jackson, Mississippi, Forenede Stater, 39216
    - University of Mississippi Medical Center
- Missouri
  - Ballwin, Missouri, Forenede Stater, 63011
    - Mercy Oncology and Hematology - Clayton-Clarkson
  - Bolivar, Missouri, Forenede Stater, 65613
    - Central Care Cancer Center - Bolivar
  - Bonne Terre, Missouri, Forenede Stater, 63628
    - Parkland Health Center-Bonne Terre
  - Branson, Missouri, Forenede Stater, 65616
    - Cox Cancer Center Branson
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Mercy Cancer Center - Cape Girardeau
  - Farmington, Missouri, Forenede Stater, 63640
    - Parkland Health Center - Farmington
  - Jefferson City, Missouri, Forenede Stater, 65109
    - MU Health Care Goldschmidt Cancer Center
  - Joplin, Missouri, Forenede Stater, 64804
    - Freeman Health System
  - Joplin, Missouri, Forenede Stater, 64804
    - Mercy Hospital Joplin
  - Kansas City, Missouri, Forenede Stater, 64108
    - University Health Truman Medical Center
  - North Kansas City, Missouri, Forenede Stater, 64116
    - University of Kansas Cancer Center at North Kansas City Hospital
  - Rolla, Missouri, Forenede Stater, 65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Rolla, Missouri, Forenede Stater, 65401
    - Phelps Health Delbert Day Cancer Institute
  - Saint Joseph, Missouri, Forenede Stater, 64506
    - Heartland Regional Medical Center
  - Sainte Genevieve, Missouri, Forenede Stater, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Forenede Stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forenede Stater, 65804
    - Mercy Hospital Springfield
  - St Louis, Missouri, Forenede Stater, 63110
    - Washington University School of Medicine
  - St Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Medical Center
  - St Louis, Missouri, Forenede Stater, 63109
    - Mercy Infusion Center - Chippewa
  - St Louis, Missouri, Forenede Stater, 63141
    - Mercy Hospital Saint Louis
  - St Louis, Missouri, Forenede Stater, 63128
    - Mercy Hospital South
  - Sullivan, Missouri, Forenede Stater, 63080
    - Missouri Baptist Sullivan Hospital
  - Sunset Hills, Missouri, Forenede Stater, 63127
    - BJC Outpatient Center at Sunset Hills
  - Washington, Missouri, Forenede Stater, 63090
    - Mercy Hospital Washington
- Montana
  - Anaconda, Montana, Forenede Stater, 59711
    - Community Hospital of Anaconda
  - Billings, Montana, Forenede Stater, 59101
    - Billings Clinic Cancer Center
  - Billings, Montana, Forenede Stater, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Forenede Stater, 59102
    - Saint Vincent Frontier Cancer Center
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Health Deaconess Hospital
  - Butte, Montana, Forenede Stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Forenede Stater, 59405
    - Benefis Sletten Cancer Institute
  - Helena, Montana, Forenede Stater, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Forenede Stater, 59901
    - Logan Health Medical Center
  - Missoula, Montana, Forenede Stater, 59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula, Montana, Forenede Stater, 59804
    - Community Medical Center
- Nebraska
  - Grand Island, Nebraska, Forenede Stater, 68803
    - Nebraska Cancer Specialists/Oncology Hematology West PC
  - Kearney, Nebraska, Forenede Stater, 68847
    - CHI Health Good Samaritan
  - Kearney, Nebraska, Forenede Stater, 68845
    - Fred and Pamela Buffett Cancer Center - Kearney
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Saint Elizabeth Regional Medical Center
  - Omaha, Nebraska, Forenede Stater, 68114
    - Nebraska Methodist Hospital
  - Omaha, Nebraska, Forenede Stater, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Forenede Stater, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Forenede Stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Forenede Stater, 68131
    - Creighton University Medical Center
  - Omaha, Nebraska, Forenede Stater, 68122
    - Hematology and Oncology Consultants PC
  - Papillion, Nebraska, Forenede Stater, 68046
    - Midlands Community Hospital
- Nevada
  - Carson City, Nevada, Forenede Stater, 89703
    - Carson Tahoe Regional Medical Center
  - Henderson, Nevada, Forenede Stater, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, Forenede Stater, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Comprehensive Cancer Centers of Nevada-Horizon Ridge
  - Henderson, Nevada, Forenede Stater, 89074
    - Las Vegas Urology - Green Valley
  - Henderson, Nevada, Forenede Stater, 89074
    - Las Vegas Urology - Pebble
  - Henderson, Nevada, Forenede Stater, 89074
    - Urology Specialists of Nevada - Green Valley
  - Henderson, Nevada, Forenede Stater, 89074
    - Oncology Las Vegas - Henderson
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Summerlin Hospital Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89109
    - Sunrise Hospital and Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89102
    - OptumCare Cancer Care at Charleston
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, Forenede Stater, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, Forenede Stater, 89128
    - OptumCare Cancer Care at MountainView
  - Las Vegas, Nevada, Forenede Stater, 89135
    - Alliance for Childhood Diseases/Cure 4 the Kids Foundation
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Comprehensive Cancer Centers of Nevada - Town Center
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, Forenede Stater, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Forenede Stater, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Women's Cancer Center of Nevada
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Cancer and Blood Specialists-Shadow
  - Las Vegas, Nevada, Forenede Stater, 89109
    - HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
  - Las Vegas, Nevada, Forenede Stater, 89113
    - HealthCare Partners Medical Group Oncology/Hematology-San Martin
  - Las Vegas, Nevada, Forenede Stater, 89121
    - Cancer Therapy and Integrative Medicine
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Cancer and Blood Specialists-Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89128
    - HealthCare Partners Medical Group Oncology/Hematology-Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89149
    - HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Ann M Wierman MD LTD
  - Las Vegas, Nevada, Forenede Stater, 89074
    - Las Vegas Urology - Pecos
  - Las Vegas, Nevada, Forenede Stater, 89102
    - Desert West Surgery
  - Las Vegas, Nevada, Forenede Stater, 89103
    - Hope Cancer Care of Nevada
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Urology Specialists of Nevada - Central
  - Las Vegas, Nevada, Forenede Stater, 89113
    - Las Vegas Prostate Cancer Center
  - Las Vegas, Nevada, Forenede Stater, 89113
    - Las Vegas Urology - Sunset
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Las Vegas Urology - Cathedral Rock
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Las Vegas Urology - Smoke Ranch
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Urology Specialists of Nevada - Northwest
  - Las Vegas, Nevada, Forenede Stater, 89169
    - University Cancer Center
  - Las Vegas, Nevada, Forenede Stater, 89113
    - Urology Specialists of Nevada - Southwest
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Oncology Las Vegas - Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89183
    - OptumCare Cancer Care at Fort Apache
  - Pahrump, Nevada, Forenede Stater, 89048
    - Hope Cancer Care of Nevada-Pahrump
  - Reno, Nevada, Forenede Stater, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89503
    - Saint Mary's Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89509
    - Radiation Oncology Associates
- New Hampshire
  - Lebanon, New Hampshire, Forenede Stater, 03756
    - Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
  - Nashua, New Hampshire, Forenede Stater, 03063
    - Dartmouth Cancer Center - Nashua
- New Jersey
  - Basking Ridge, New Jersey, Forenede Stater, 07920
    - Memorial Sloan Kettering Basking Ridge
  - Cape May Court House, New Jersey, Forenede Stater, 08210
    - AtlantiCare Health Park-Cape May Court House
  - Egg Harbor, New Jersey, Forenede Stater, 08234
    - AtlantiCare Surgery Center
  - Hackensack, New Jersey, Forenede Stater, 07601
    - Hackensack University Medical Center
  - Hamilton, New Jersey, Forenede Stater, 08690
    - The Cancer Institute of New Jersey Hamilton
  - Lakewood, New Jersey, Forenede Stater, 08701
    - Monmouth Medical Center Southern Campus
  - Long Branch, New Jersey, Forenede Stater, 07740
    - Monmouth Medical Center
  - Middletown, New Jersey, Forenede Stater, 07748
    - Memorial Sloan Kettering Monmouth
  - Montvale, New Jersey, Forenede Stater, 07645
    - Memorial Sloan Kettering Bergen
  - New Brunswick, New Jersey, Forenede Stater, 08903
    - Rutgers Cancer Institute of New Jersey
  - Paramus, New Jersey, Forenede Stater, 07652
    - The Valley Hospital - Luckow Pavilion
  - Ridgewood, New Jersey, Forenede Stater, 07450
    - Neurosurgeons of New Jersey-Ridgewood
  - Ridgewood, New Jersey, Forenede Stater, 07450
    - Valley Health System Ridgewood Campus
  - Somerville, New Jersey, Forenede Stater, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Wayne, New Jersey, Forenede Stater, 07470
    - Valley Medical Group - Wayne Multispecialty Practice
  - Westwood, New Jersey, Forenede Stater, 07675
    - Valley Health System-Hematology/Oncology
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87106
    - Southwest Gynecologic Oncology Associates Inc
  - Albuquerque, New Mexico, Forenede Stater, 87106
    - University of New Mexico Cancer Center
  - Rio Rancho, New Mexico, Forenede Stater, 87124
    - Presbyterian Rust Medical Center/Jorgensen Cancer Center
- New York
  - Albany, New York, Forenede Stater, 12208
    - Women's Cancer Care Associates LLC
  - Buffalo, New York, Forenede Stater, 14263
    - Roswell Park Cancer Institute
  - Commack, New York, Forenede Stater, 11725
    - Memorial Sloan Kettering Commack
  - Harrison, New York, Forenede Stater, 10604
    - Memorial Sloan Kettering Westchester
  - Lake Success, New York, Forenede Stater, 11042
    - Northwell Health/Center for Advanced Medicine
  - New York, New York, Forenede Stater, 10065
    - Memorial Sloan Kettering Cancer Center
  - New York, New York, Forenede Stater, 10029
    - Mount Sinai Hospital
  - New York, New York, Forenede Stater, 10011
    - Mount Sinai Chelsea
  - New York, New York, Forenede Stater, 10016
    - Laura and Isaac Perlmutter Cancer Center at NYU Langone
  - New York, New York, Forenede Stater, 10075
    - Lenox Hill Hospital
  - New York, New York, Forenede Stater, 10065
    - Manhattan Eye Ear and Throat Hospital
  - Rochester, New York, Forenede Stater, 14642
    - University of Rochester
  - Syracuse, New York, Forenede Stater, 13210
    - State University of New York Upstate Medical University
  - Syracuse, New York, Forenede Stater, 13215
    - SUNY Upstate Medical Center-Community Campus
  - The Bronx, New York, Forenede Stater, 10461
    - Montefiore Medical Center-Einstein Campus
  - The Bronx, New York, Forenede Stater, 10467
    - Montefiore Medical Center - Moses Campus
  - The Bronx, New York, Forenede Stater, 10461
    - Montefiore Medical Center-Weiler Hospital
  - Uniondale, New York, Forenede Stater, 11553
    - Memorial Sloan Kettering Nassau
  - White Plains, New York, Forenede Stater, 10601
    - Dickstein Cancer Treatment Center
- North Carolina
  - Asheboro, North Carolina, Forenede Stater, 27203
    - Randolph Hospital
  - Asheville, North Carolina, Forenede Stater, 28816
    - Hope Women's Cancer Centers-Asheville
  - Burlington, North Carolina, Forenede Stater, 27215
    - Cone Health Cancer Center at Alamance Regional
  - Chapel Hill, North Carolina, Forenede Stater, 27599
    - UNC Lineberger Comprehensive Cancer Center
  - Charlotte, North Carolina, Forenede Stater, 28203
    - Carolinas Medical Center/Levine Cancer Institute
  - Charlotte, North Carolina, Forenede Stater, 28204
    - Novant Health Presbyterian Medical Center
  - Clinton, North Carolina, Forenede Stater, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Concord, North Carolina, Forenede Stater, 28025
    - Atrium Health Cabarrus/LCI-Concord
  - Durham, North Carolina, Forenede Stater, 27710
    - Duke University Medical Center
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Memorial Hospital
  - Greensboro, North Carolina, Forenede Stater, 27403
    - Cone Health Cancer Center
  - Hendersonville, North Carolina, Forenede Stater, 28791
    - Margaret R Pardee Memorial Hospital
  - Huntersville, North Carolina, Forenede Stater, 28078
    - Novant Health Presbyterian Medical Center Huntersville
  - Jacksonville, North Carolina, Forenede Stater, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Jacksonville, North Carolina, Forenede Stater, 28546
    - Onslow Memorial Hospital
  - Kernersville, North Carolina, Forenede Stater, 27284
    - Novant Health Cancer Institute - Kernersville
  - Mebane, North Carolina, Forenede Stater, 27302
    - Cone Heath Cancer Center at Mebane
  - Mount Airy, North Carolina, Forenede Stater, 27030
    - Novant Health Cancer Institute - Mount Airy
  - North Wilkesboro, North Carolina, Forenede Stater, 28659
    - Novant Health Cancer Institute - Wilkesboro
  - Raleigh, North Carolina, Forenede Stater, 27609
    - Duke Cancer Center Raleigh
  - Reidsville, North Carolina, Forenede Stater, 27320
    - Annie Penn Memorial Hospital
  - Statesville, North Carolina, Forenede Stater, 28625
    - Novant Health Cancer Institute - Statesville
  - Thomasville, North Carolina, Forenede Stater, 27360
    - Novant Health Cancer Institute - Thomasville
  - Wilmington, North Carolina, Forenede Stater, 28401
    - Novant Health New Hanover Regional Medical Center
  - Winston-Salem, North Carolina, Forenede Stater, 27103
    - Novant Health Forsyth Medical Center
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Sanford Bismarck Medical Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Roger Maris Cancer Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Broadway Medical Center
  - Fargo, North Dakota, Forenede Stater, 58103
    - Sanford South University Medical Center
- Ohio
  - Alliance, Ohio, Forenede Stater, 44601
    - Aultman Alliance Community Hospital
  - Beachwood, Ohio, Forenede Stater, 44122
    - UHHS-Chagrin Highlands Medical Center
  - Beavercreek, Ohio, Forenede Stater, 45431
    - Indu and Raj Soin Medical Center
  - Belpre, Ohio, Forenede Stater, 45714
    - Strecker Cancer Center-Belpre
  - Boardman, Ohio, Forenede Stater, 44512
    - Saint Elizabeth Boardman Hospital
  - Canton, Ohio, Forenede Stater, 44710
    - Aultman Health Foundation
  - Centerville, Ohio, Forenede Stater, 45459
    - Miami Valley Hospital South
  - Centerville, Ohio, Forenede Stater, 45459
    - Dayton Physicians LLC-Miami Valley South
  - Chardon, Ohio, Forenede Stater, 44024
    - Geauga Hospital
  - Chillicothe, Ohio, Forenede Stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45219
    - University of Cincinnati Cancer Center-UC Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, Forenede Stater, 45242
    - Bethesda North Hospital
  - Cincinnati, Ohio, Forenede Stater, 45236
    - Oncology Hematology Care Inc-Kenwood
  - Cincinnati, Ohio, Forenede Stater, 45247
    - TriHealth Cancer Institute-Westside
  - Cincinnati, Ohio, Forenede Stater, 45255
    - TriHealth Cancer Institute-Anderson
  - Cleveland, Ohio, Forenede Stater, 44106
    - Case Western Reserve University
  - Cleveland, Ohio, Forenede Stater, 44109
    - MetroHealth Medical Center
  - Cleveland, Ohio, Forenede Stater, 44195
    - Cleveland Clinic Foundation
  - Cleveland, Ohio, Forenede Stater, 44111
    - Cleveland Clinic Cancer Center/Fairview Hospital
  - Columbus, Ohio, Forenede Stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forenede Stater, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Forenede Stater, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Forenede Stater, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Forenede Stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forenede Stater, 43213
    - Mount Carmel East Hospital
  - Columbus, Ohio, Forenede Stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel Health Center West
  - Dayton, Ohio, Forenede Stater, 45406
    - Good Samaritan Hospital - Dayton
  - Dayton, Ohio, Forenede Stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Miami Valley Hospital North
  - Dayton, Ohio, Forenede Stater, 45405
    - Grandview Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Dayton Physician LLC - Englewood
  - Delaware, Ohio, Forenede Stater, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Forenede Stater, 43015
    - Delaware Radiation Oncology
  - Delaware, Ohio, Forenede Stater, 43015
    - Grady Memorial Hospital
  - Dublin, Ohio, Forenede Stater, 43016
    - Dublin Methodist Hospital
  - Elyria, Ohio, Forenede Stater, 44035
    - Mercy Cancer Center-Elyria
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Hospital
  - Findlay, Ohio, Forenede Stater, 45840
    - Armes Family Cancer Center
  - Findlay, Ohio, Forenede Stater, 45840
    - Orion Cancer Care
  - Franklin, Ohio, Forenede Stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Franklin, Ohio, Forenede Stater, 45005
    - Dayton Physicians LLC-Atrium
  - Greenville, Ohio, Forenede Stater, 45331
    - Wayne Hospital
  - Greenville, Ohio, Forenede Stater, 45331
    - Dayton Physicians LLC-Wayne
  - Grove City, Ohio, Forenede Stater, 43123
    - Mount Carmel Grove City Hospital
  - Kettering, Ohio, Forenede Stater, 45429
    - Kettering Medical Center
  - Kettering, Ohio, Forenede Stater, 45409
    - Greater Dayton Cancer Center
  - Kettering, Ohio, Forenede Stater, 45420
    - First Dayton Cancer Care
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Forenede Stater, 45801
    - Saint Rita's Medical Center
  - Mansfield, Ohio, Forenede Stater, 44903
    - OhioHealth Mansfield Hospital
  - Marietta, Ohio, Forenede Stater, 45750
    - Marietta Memorial Hospital
  - Marion, Ohio, Forenede Stater, 43302
    - OhioHealth Marion General Hospital
  - Mayfield Heights, Ohio, Forenede Stater, 44124
    - Hillcrest Hospital Cancer Center
  - Mentor, Ohio, Forenede Stater, 44060
    - UH Seidman Cancer Center at Lake Health Mentor Campus
  - Middleburg Heights, Ohio, Forenede Stater, 44130
    - UH Seidman Cancer Center at Southwest General Hospital
  - Mount Vernon, Ohio, Forenede Stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Newark Radiation Oncology
  - Perrysburg, Ohio, Forenede Stater, 43551
    - Mercy Health - Perrysburg Hospital
  - Portsmouth, Ohio, Forenede Stater, 45662
    - Southern Ohio Medical Center
  - Sandusky, Ohio, Forenede Stater, 44870
    - UH Seidman Cancer Center at Firelands Regional Medical Center
  - Springfield, Ohio, Forenede Stater, 45504
    - Springfield Regional Cancer Center
  - Springfield, Ohio, Forenede Stater, 45504
    - Springfield Regional Medical Center
  - Sylvania, Ohio, Forenede Stater, 43560
    - ProMedica Flower Hospital
  - Toledo, Ohio, Forenede Stater, 43606
    - ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
  - Toledo, Ohio, Forenede Stater, 43623
    - Mercy Health - Saint Anne Hospital
  - Toledo, Ohio, Forenede Stater, 43608
    - Mercy Health - Saint Vincent Hospital
  - Troy, Ohio, Forenede Stater, 45373
    - Upper Valley Medical Center
  - Troy, Ohio, Forenede Stater, 45373
    - Dayton Physicians LLC - Troy
  - Wadsworth, Ohio, Forenede Stater, 44281
    - University Hospitals Sharon Health Center
  - Warren, Ohio, Forenede Stater, 44484
    - Saint Joseph Warren Hospital
  - West Chester, Ohio, Forenede Stater, 45069
    - University of Cincinnati Cancer Center-West Chester
  - Westerville, Ohio, Forenede Stater, 43081
    - Saint Ann's Hospital
  - Westlake, Ohio, Forenede Stater, 44145
    - UH Seidman Cancer Center at Saint John Medical Center
  - Westlake, Ohio, Forenede Stater, 44145
    - UHHS-Westlake Medical Center
  - Youngstown, Ohio, Forenede Stater, 44501
    - Saint Elizabeth Youngstown Hospital
  - Zanesville, Ohio, Forenede Stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Mercy Hospital Oklahoma City
  - Tulsa, Oklahoma, Forenede Stater, 74146
    - Oklahoma Cancer Specialists and Research Institute-Tulsa
  - Tulsa, Oklahoma, Forenede Stater, 74133
    - Cancer Treatment Centers of America
- Oregon
  - Baker City, Oregon, Forenede Stater, 97814
    - Saint Alphonsus Cancer Care Center-Baker City
  - Bend, Oregon, Forenede Stater, 97701
    - Saint Charles Health System
  - Clackamas, Oregon, Forenede Stater, 97015
    - Clackamas Radiation Oncology Center
  - Clackamas, Oregon, Forenede Stater, 97015
    - Providence Cancer Institute Clackamas Clinic
  - Coos Bay, Oregon, Forenede Stater, 97420
    - Bay Area Hospital
  - Gresham, Oregon, Forenede Stater, 97030
    - Legacy Mount Hood Medical Center
  - Newberg, Oregon, Forenede Stater, 97132
    - Providence Newberg Medical Center
  - Ontario, Oregon, Forenede Stater, 97914
    - Saint Alphonsus Cancer Care Center-Ontario
  - Portland, Oregon, Forenede Stater, 97210
    - Legacy Good Samaritan Hospital and Medical Center
  - Portland, Oregon, Forenede Stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - Providence Saint Vincent Medical Center
  - Tualatin, Oregon, Forenede Stater, 97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Abington, Pennsylvania, Forenede Stater, 19001
    - Jefferson Abington Hospital
  - Allentown, Pennsylvania, Forenede Stater, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Bethlehem, Pennsylvania, Forenede Stater, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bethlehem, Pennsylvania, Forenede Stater, 18015
    - Saint Luke's University Hospital-Bethlehem Campus
  - Bryn Mawr, Pennsylvania, Forenede Stater, 19010
    - Bryn Mawr Hospital
  - Chadds Ford, Pennsylvania, Forenede Stater, 19317
    - Christiana Care Health System-Concord Health Center
  - Chambersburg, Pennsylvania, Forenede Stater, 17201
    - Chambersburg Hospital
  - Collegeville, Pennsylvania, Forenede Stater, 19426
    - Main Line Health Center-Collegeville
  - Danville, Pennsylvania, Forenede Stater, 17822
    - Geisinger Medical Center
  - East Stroudsburg, Pennsylvania, Forenede Stater, 18301
    - Pocono Medical Center
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Cancer Center
  - Exton, Pennsylvania, Forenede Stater, 19341
    - Main Line Health Center-Exton
  - Gettysburg, Pennsylvania, Forenede Stater, 17325
    - Adams Cancer Center
  - Hanover, Pennsylvania, Forenede Stater, 17331
    - WellSpan Medical Oncology and Hematology
  - Harrisburg, Pennsylvania, Forenede Stater, 17109
    - UPMC Pinnacle Cancer Center/Community Osteopathic Campus
  - Hazleton, Pennsylvania, Forenede Stater, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hazleton, Pennsylvania, Forenede Stater, 18201
    - Lehigh Valley Hospital-Hazleton
  - Jefferson Hills, Pennsylvania, Forenede Stater, 15025
    - Jefferson Hospital
  - Lancaster, Pennsylvania, Forenede Stater, 17601
    - Lancaster General Ann B Barshinger Cancer Institute
  - Lancaster, Pennsylvania, Forenede Stater, 17602
    - Lancaster General Hospital
  - Lebanon, Pennsylvania, Forenede Stater, 17042
    - Sechler Family Cancer Center
  - Lewisburg, Pennsylvania, Forenede Stater, 17837
    - Geisinger Medical Oncology-Lewisburg
  - Lewistown, Pennsylvania, Forenede Stater, 17044
    - Lewistown Hospital
  - Media, Pennsylvania, Forenede Stater, 19063
    - Riddle Memorial Hospital
  - Monroeville, Pennsylvania, Forenede Stater, 15146
    - Forbes Hospital
  - New Castle, Pennsylvania, Forenede Stater, 16105
    - Medical Center Clinic-New Castle Office
  - Paoli, Pennsylvania, Forenede Stater, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19104
    - University of Pennsylvania/Abramson Cancer Center
  - Pittsburgh, Pennsylvania, Forenede Stater, 15212
    - Allegheny General Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15224
    - West Penn Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - University of Pittsburgh Cancer Institute (UPCI)
  - Pottsville, Pennsylvania, Forenede Stater, 17901
    - Geisinger Cancer Services-Pottsville
  - Scranton, Pennsylvania, Forenede Stater, 18510
    - Community Medical Center
  - Selinsgrove, Pennsylvania, Forenede Stater, 17870
    - Geisinger Medical Oncology-Selinsgrove
  - State College, Pennsylvania, Forenede Stater, 16801
    - Geisinger Medical Group
  - West Chester, Pennsylvania, Forenede Stater, 19380
    - Chester County Hospital
  - West Reading, Pennsylvania, Forenede Stater, 19611
    - Reading Hospital
  - Wexford, Pennsylvania, Forenede Stater, 15090
    - Wexford Health and Wellness Pavilion
  - Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Willow Grove, Pennsylvania, Forenede Stater, 19090
    - Asplundh Cancer Pavilion
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Lankenau Medical Center
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Cancer Center
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Hospital
- Rhode Island
  - Providence, Rhode Island, Forenede Stater, 02905
    - Women and Infants Hospital
- South Carolina
  - Anderson, South Carolina, Forenede Stater, 29621
    - AnMed Health Cancer Center
  - Charleston, South Carolina, Forenede Stater, 29425
    - Medical University of South Carolina
  - Gaffney, South Carolina, Forenede Stater, 29341
    - Gibbs Cancer Center-Gaffney
  - Greenville, South Carolina, Forenede Stater, 29607
    - Saint Francis Cancer Center
  - Greenville, South Carolina, Forenede Stater, 29601
    - Saint Francis Hospital
  - Greer, South Carolina, Forenede Stater, 29651
    - Gibbs Cancer Center-Pelham
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Spartanburg Medical Center
  - Union, South Carolina, Forenede Stater, 29379
    - SMC Center for Hematology Oncology Union
- South Dakota
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sanford Cancer Center Oncology Clinic
- Tennessee
  - Bristol, Tennessee, Forenede Stater, 37620
    - Bristol Regional Medical Center
  - Chattanooga, Tennessee, Forenede Stater, 37404
    - Memorial Hospital
  - Franklin, Tennessee, Forenede Stater, 37067
    - Vanderbilt-Ingram Cancer Center Cool Springs
  - Hixson, Tennessee, Forenede Stater, 37343
    - Pulmonary Medicine Center of Chattanooga-Hixson
  - Johnson City, Tennessee, Forenede Stater, 37604
    - Wellmont Medical Associates Oncology and Hematology-Johnson City
  - Kingsport, Tennessee, Forenede Stater, 37660
    - Ballad Health Cancer Care - Kingsport
  - Kingsport, Tennessee, Forenede Stater, 37660
    - Wellmont Holston Valley Hospital and Medical Center
  - Knoxville, Tennessee, Forenede Stater, 37916
    - Covenant Health Cancer Centers
  - Knoxville, Tennessee, Forenede Stater, 37932
    - Covenant Health Cancer Centers - West
  - Nashville, Tennessee, Forenede Stater, 37232
    - Vanderbilt University/Ingram Cancer Center
  - Nashville, Tennessee, Forenede Stater, 37204
    - Vanderbilt Breast Center at One Hundred Oaks
  - Oak Ridge, Tennessee, Forenede Stater, 37830
    - Covenant Health Oncology Group - Oak Ridge
  - Ooltewah, Tennessee, Forenede Stater, 37363
    - Memorial GYN Plus
- Texas
  - Bryan, Texas, Forenede Stater, 77802
    - Saint Joseph Regional Cancer Center
  - Dallas, Texas, Forenede Stater, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, Forenede Stater, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - Fort Worth, Texas, Forenede Stater, 76104
    - UT Southwestern/Simmons Cancer Center-Fort Worth
  - Houston, Texas, Forenede Stater, 77030
    - Houston Methodist Hospital
  - Houston, Texas, Forenede Stater, 77030
    - Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
  - Houston, Texas, Forenede Stater, 77070
    - Methodist Willowbrook Hospital
  - Houston, Texas, Forenede Stater, 77030
    - Ben Taub General Hospital
  - Houston, Texas, Forenede Stater, 77094
    - Houston Methodist West Hospital
  - Sugar Land, Texas, Forenede Stater, 77479
    - Houston Methodist Sugar Land Hospital
  - The Woodlands, Texas, Forenede Stater, 77385
    - Houston Methodist The Woodlands Hospital
- Virginia
  - Bristol, Virginia, Forenede Stater, 24201
    - Ballad Health Cancer Care - Bristol
  - Burke, Virginia, Forenede Stater, 22015
    - Kaiser Permanente-Burke Medical Center
  - Charlottesville, Virginia, Forenede Stater, 22908
    - University of Virginia Cancer Center
  - Fairfax, Virginia, Forenede Stater, 22031
    - Inova Schar Cancer Institute
  - Falls Church, Virginia, Forenede Stater, 22042
    - Inova Fairfax Hospital
  - McLean, Virginia, Forenede Stater, 22102
    - Kaiser Permanente Tysons Corner Medical Center
  - Norton, Virginia, Forenede Stater, 24273
    - Ballad Health Cancer Care - Norton
  - Richmond, Virginia, Forenede Stater, 23229
    - Virginia Gynecologic Oncology
  - Richmond, Virginia, Forenede Stater, 23298
    - VCU Massey Comprehensive Cancer Center
  - Roanoke, Virginia, Forenede Stater, 24033
    - Carilion Roanoke Memorial Hospital
- Washington
  - Aberdeen, Washington, Forenede Stater, 98520
    - Providence Regional Cancer System-Aberdeen
  - Auburn, Washington, Forenede Stater, 98001
    - MultiCare Auburn Medical Center
  - Bainbridge Island, Washington, Forenede Stater, 98110
    - Virginia Mason Bainbridge Island Medical Center
  - Bellevue, Washington, Forenede Stater, 98004
    - Overlake Medical Center
  - Bellingham, Washington, Forenede Stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Burien, Washington, Forenede Stater, 98166
    - Highline Medical Center-Main Campus
  - Centralia, Washington, Forenede Stater, 98531
    - Providence Regional Cancer System-Centralia
  - Edmonds, Washington, Forenede Stater, 98026
    - Swedish Cancer Institute-Edmonds
  - Enumclaw, Washington, Forenede Stater, 98022
    - Saint Elizabeth Hospital
  - Everett, Washington, Forenede Stater, 98201
    - Providence Regional Cancer Partnership
  - Federal Way, Washington, Forenede Stater, 98002
    - Virginia Mason Federal Way Medical Center
  - Federal Way, Washington, Forenede Stater, 98003
    - Saint Francis Hospital
  - Gig Harbor, Washington, Forenede Stater, 98332
    - Tacoma/Valley Radiation Oncology Centers-Gig Harbor
  - Gig Harbor, Washington, Forenede Stater, 98335
    - MultiCare Gig Harbor Medical Park
  - Issaquah, Washington, Forenede Stater, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Forenede Stater, 99336
    - Kadlec Clinic Hematology and Oncology
  - Kennewick, Washington, Forenede Stater, 99336
    - Northwest Cancer Clinic
  - Lacey, Washington, Forenede Stater, 98503
    - Providence Regional Cancer System-Lacey
  - Lakewood, Washington, Forenede Stater, 98499
    - Saint Clare Hospital
  - Longview, Washington, Forenede Stater, 98632
    - PeaceHealth Saint John Medical Center
  - Lynnwood, Washington, Forenede Stater, 98036
    - Virginia Mason Lynnwood Medical Center
  - Port Townsend, Washington, Forenede Stater, 98368
    - Jefferson Healthcare
  - Poulsbo, Washington, Forenede Stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Poulsbo, Washington, Forenede Stater, 98370
    - Peninsula Cancer Center
  - Puyallup, Washington, Forenede Stater, 98372
    - MultiCare Good Samaritan Hospital
  - Puyallup, Washington, Forenede Stater, 98372
    - Tacoma/Valley Radiation Oncology Centers-Puyallup
  - Renton, Washington, Forenede Stater, 98055
    - Valley Medical Center
  - Seattle, Washington, Forenede Stater, 98101
    - Virginia Mason Medical Center
  - Seattle, Washington, Forenede Stater, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Forenede Stater, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forenede Stater, 98195
    - University of Washington Medical Center - Montlake
  - Seattle, Washington, Forenede Stater, 98112
    - Kaiser Permanente Washington
  - Seattle, Washington, Forenede Stater, 98104
    - Pacific Gynecology Specialists
  - Seattle, Washington, Forenede Stater, 98122-5711
    - Swedish Medical Center-Cherry Hill
  - Seattle, Washington, Forenede Stater, 98109
    - Fred Hutchinson Cancer Center
  - Shelton, Washington, Forenede Stater, 98584
    - Providence Regional Cancer System-Shelton
  - Silverdale, Washington, Forenede Stater, 98383
    - Saint Joseph Medical Center Hematology and Oncology - Silverdale
  - Spokane, Washington, Forenede Stater, 99204
    - MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
  - Spokane, Washington, Forenede Stater, 99218
    - MultiCare Deaconess Cancer and Blood Specialty Center - North
  - Spokane Valley, Washington, Forenede Stater, 99216
    - MultiCare Deaconess Cancer and Blood Specialty Center - Valley
  - Tacoma, Washington, Forenede Stater, 98405
    - Northwest Medical Specialties PLLC
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Tacoma General Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - Tacoma/Valley Radiation Oncology Centers-Saint Joe's
  - Tacoma, Washington, Forenede Stater, 97405
    - Tacoma/Valley Radiation Oncology Centers-Jackson Hall
  - Tacoma, Washington, Forenede Stater, 98405
    - Franciscan Research Center-Northwest Medical Plaza
  - Vancouver, Washington, Forenede Stater, 98686
    - Legacy Salmon Creek Hospital
  - Vancouver, Washington, Forenede Stater, 98664
    - PeaceHealth Southwest Medical Center
  - Walla Walla, Washington, Forenede Stater, 99362
    - Providence Saint Mary Regional Cancer Center
  - Yakima, Washington, Forenede Stater, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
  - Yelm, Washington, Forenede Stater, 98597
    - Providence Regional Cancer System-Yelm
- West Virginia
  - Bridgeport, West Virginia, Forenede Stater, 26330
    - United Hospital Center
  - Charleston, West Virginia, Forenede Stater, 25304
    - West Virginia University Charleston Division
  - Martinsburg, West Virginia, Forenede Stater, 25401
    - WVUH-Berkely Medical Center
  - Morgantown, West Virginia, Forenede Stater, 26506
    - West Virginia University Healthcare
  - Morgantown, West Virginia, Forenede Stater, 26505
    - Monongalia Hospital
  - Parkersburg, West Virginia, Forenede Stater, 26101
    - Camden Clark Medical Center
- Wisconsin
  - Burlington, Wisconsin, Forenede Stater, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Chippewa Falls, Wisconsin, Forenede Stater, 54729
    - Marshfield Clinic-Chippewa Center
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Medical Center-EC Cancer Center
  - Fond du Lac, Wisconsin, Forenede Stater, 54937
    - Aurora Health Center-Fond du Lac
  - Germantown, Wisconsin, Forenede Stater, 53022
    - Aurora Health Care Germantown Health Center
  - Grafton, Wisconsin, Forenede Stater, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Forenede Stater, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Forenede Stater, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Janesville, Wisconsin, Forenede Stater, 53548
    - Mercyhealth Hospital and Cancer Center - Janesville
  - Kenosha, Wisconsin, Forenede Stater, 53142
    - Aurora Cancer Care-Kenosha South
  - Ladysmith, Wisconsin, Forenede Stater, 54848
    - Marshfield Medical Center - Ladysmith
  - Madison, Wisconsin, Forenede Stater, 53792
    - University of Wisconsin Carbone Cancer Center - University Hospital
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Medical Center-Marshfield
  - Milwaukee, Wisconsin, Forenede Stater, 53226
    - Medical College of Wisconsin
  - Milwaukee, Wisconsin, Forenede Stater, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53233
    - Aurora Sinai Medical Center
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Medical Center - Minocqua
  - New Richmond, Wisconsin, Forenede Stater, 54017
    - Cancer Center of Western Wisconsin
  - Oconto Falls, Wisconsin, Forenede Stater, 54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Oshkosh, Wisconsin, Forenede Stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forenede Stater, 53406
    - Aurora Cancer Care-Racine
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Medical Center-Rice Lake
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Stevens Point, Wisconsin, Forenede Stater, 54482
    - Marshfield Medical Center-River Region at Stevens Point
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
    - Saint Vincent Hospital Cancer Center at Sturgeon Bay
  - Summit, Wisconsin, Forenede Stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forenede Stater, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Marshfield Clinic-Wausau Center
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - West Allis, Wisconsin, Forenede Stater, 53227
    - Aurora West Allis Medical Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Medical Center - Weston
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
- Wyoming
  - Cheyenne, Wyoming, Forenede Stater, 82001
    - Cheyenne Regional Medical Center-West
  - Cody, Wyoming, Forenede Stater, 82414
    - Billings Clinic-Cody
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center
Puerto Rico
- - Aguadilla, Puerto Rico, 00603
    - Advance Oncology Center
  - Arecibo, Puerto Rico, 00614
    - Doctor's Cancer Center-Arecibo
  - Bayamón, Puerto Rico, 00959-5060
    - Cancer Center-Metro Medical Center Bayamon
  - Bayamón, Puerto Rico, 00961
    - Hematologia Oncologia San Pablo
  - Caguas, Puerto Rico, 00726
    - HIMA San Pablo Oncologic Hospital
  - Manati, Puerto Rico, 00674
    - Doctors Cancer Center
  - Ponce, Puerto Rico, 00716
    - Instituto Oncologia Moderna Ponce
  - San Juan, Puerto Rico, 00917
    - San Juan Community Oncology Group
  - San Juan, Puerto Rico, 00927
    - Centro Comprensivo de Cancer de UPR
  - San Juan, Puerto Rico, 00936
    - San Juan City Hospital
  - San Juan, Puerto Rico, 00920
    - Primary Care Physician Group
  - Santa Isabel, Puerto Rico, 00757
    - Centro de Hematologia y Oncologia del Sur

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

Patienterne skal have den psykologiske evne og det generelle helbred, der tillader gennemførelse af undersøgelseskravene og påkrævet opfølgning
Administration af undersøgelseslægemidler (pegyleret liposomalt doxorubicin, bevacizumab, atezolizumab) kan have en negativ virkning på graviditet og udgøre en risiko for det menneskelige foster, herunder embryodødelighed; kvinder i den fødedygtige alder (WOCBP) skal acceptere at bruge passende prævention (hormonel prævention eller barrieremetode til prævention; abstinens) før studiestart, så længe undersøgelsesdeltagelsen varer, og i 5 måneder (150 dage) efter den sidste dosis af undersøgelse agent; Hvis en kvinde bliver gravid eller har mistanke om, at hun er gravid, mens hun deltager i denne undersøgelse, skal hun straks informere sin behandlende læge. (29/06/2017)
Indsendelse af tumorvæv er påkrævet for alle patienter; efterforskere bør tjekke med deres patologiske afdeling vedrørende frigivelse af bioprøver, før de henvender sig til patienter om deltagelse i forsøget
Højgradig ovariecancer, herunder højgradig serøs; klar celle; endometrioid, grad 3; og andre (adenokarcinom, ikke på anden måde specificeret [NOS]; blandet epitelcarcinom; udifferentieret carcinom); BEMÆRK: lavgradige serøse, mucinøse og carcinosarkom-histologier er udelukket på grund af deres forskellige underliggende genomiske træk og/eller klinisk adfærd; ovariecancer = ovarie-, æggeleder- eller primær peritoneal cancer; påkrævet dataelement: indsendelse af patologirapport
Tilbagevendende, platinresistent ovariecancer (defineret som progression inden for < 6 måneder fra afslutning af platinbaseret behandling; datoen skal beregnes ud fra den sidst administrerede dosis platinbehandling)
1-2 tidligere regimer (herunder primær terapi); hormonelle terapier (f.eks. tamoxifen, aromatasehæmmere) vil ikke tælle med i forhold til den tidligere regimegrænse; PARP-hæmmere givet i vedligeholdelsesindstillingen efter respons på platinbaseret behandling vil ikke tælle som et separat regime fra den foregående platinbaserede behandling. (30. OKT-2020)
Målbar sygdom (defineret af RECIST v1.1) eller evaluerbar sygdom (defineret som faste og/eller cystiske abnormiteter på røntgenbilleder, der ikke opfylder RECIST 1.1-definitioner for mållæsioner ELLER ascites og/eller pleural effusion, der er patologisk påvist at være sygdom relateret i forhold til cancerantigen [CA] 125 >= 2 x øvre grænse for normal [ULN])
Alder >= 18 år
Ydeevnestatus 0, 1 eller 2
Absolut neutrofiltal (ANC) >= 1.500/mcl (inden for 14 dage før registrering)
Blodplader >= 100.000/mcl (inden for 14 dage før registrering)
Hæmoglobin (Hgb) >= 8 g/dl (inden for 14 dage før registrering)
Kreatinin =< 1,5 x institutionel øvre normalgrænse (ULN) (inden for 14 dage før registrering)
Urinprotein kreatinin (UPC) forholdet skal være < 1,0 (inden for 14 dage før registrering); hvis UPC-forhold >= 1, anbefales indsamling af 24-timers urinmåling af urinprotein (24-timers urinproteinniveau skal være < 1000 mg for patientindskrivning); Hvis UPC-forholdet ikke kan beregnes, fordi urinproteinet er under den nedre grænse for detektion af analysen, vil dette ikke udelukke patienten (22/10/2018) (30-OCT-2020); UPC-forhold af pleturin er et estimat af 24-timers urinproteinudskillelse - et UPC-forhold på 1 svarer nogenlunde til et 24-timers urinprotein på 1 g
Total bilirubin =< 1,5 x ULN (patienter med kendt Gilbert-sygdom, som har serumbilirubinniveau =< 3 x ULN, kan tilmeldes) (inden for 14 dage før registrering)
Aspartataminotransferase (AST)/alaninaminotransferase (ALT) =< 3 x ULN (AST og/eller ALT =< 5 x ULN for patienter med leverpåvirkning) (inden for 14 dage før registrering)
International normaliseret ratio (INR) og aktiveret partiel tromboplastintid (aPTT) =< 1,5 x ULN (eller på stabil dosis af terapeutisk antikoagulering, såsom lavmolekylært heparin, warfarin eller rivaroxaban) (16/10/2017)
Skjoldbruskkirtelstimulerende hormon (TSH) inden for normale grænser (Euthyroidpatienter i thyreoidea-substitutionsterapi tilladt forudsat TSH < ULN) (20/02/2019)
Patienten eller den juridisk autoriserede repræsentant skal give undersøgelsesspecifikt informeret samtykke forud for undersøgelsens deltagelse og, for patienter behandlet i USA (USA), godkendelse, der tillader frigivelse af personlige helbredsoplysninger

Ekskluderingskriterier:

Patienter med tidligere allogen knoglemarvstransplantation eller tidligere solid organtransplantation
Patienter, der har haft systemisk anticancerterapi (f.eks. kemoterapi, målrettet behandling inklusive PARP-hæmmere eller bevacizumab) inden for 3 uger før indtræden i undersøgelsen (30. OKT-2020)
Patienter, der har haft hormonbehandling (f.eks. tamoxifen, aromatasehæmmer) inden for 1 uge før indtræden i undersøgelsen
Patienter med tidligere behandling med anti-programmeret celledød (PD)-1, anti-programmeret celledødsligand (PD-L)1 eller anti-cytotoksisk T-lymfocyt-associeret protein (CTLA)-4 terapeutisk antistof eller andre lignende midler ( 16/10/2017)
Patienter med tidligere behandling med bevacizumab (eller enhver anden antivaskulær terapi, f.eks. cediranib) for platinresistent tilbagefald; (Bemærk: tidligere bevacizumab i indledende behandling og/eller platinfølsomme tilbagevendende omgivelser er tilladt) (16/10/2017)
Patienter med tidligere behandling med PLD
Forudgående strålebehandling til mave eller bækken
Patienter, der ikke er kommet sig efter bivirkninger til =< grad 1 (ud over alopeci) på grund af midler administreret mere end 3 uger tidligere (16/10/2017); dog er følgende terapier tilladt:
- Hormonerstatningsterapi eller orale præventionsmidler
- Urtebehandling > 1 uge før cyklus 1, dag 1 (urtebehandling beregnet som kræftbehandling skal seponeres mindst 1 uge før cyklus 1, dag 1)
- Palliativ strålebehandling for knoglemetastaser > 2 uger før cyklus 1, dag 1
Behandling med ethvert andet forsøgsmiddel inden for 4 uger før cyklus 1, dag 1
Behandling med systemiske immunstimulerende midler (herunder, men ikke begrænset til, interferon [IFN]-alfa eller interleukin [IL]-2) inden for 6 uger før cyklus 1, dag 1
Behandling med systemisk immunsuppressiv medicin (herunder, men ikke begrænset til, prednison, cyclophosphamid, azathioprin, methotrexat, thalidomid og antitumornekrosefaktor [anti-TNF]-midler) inden for 2 uger før cyklus 1, dag 1
- Patienter, der har modtaget akut, lavdosis, systemisk immunsuppressiv medicin (f.eks. en engangsdosis af dexamethason mod kvalme eller steroider som computertomografi [CT]-scanningskontrastpræmedicinering) kan tilmeldes
- Brug af inhalerede kortikosteroider og mineralokortikoider (f.eks. fludrocortison) til patienter med ortostatisk hypotension eller binyrebarkinsufficiens er tilladt
Patienter, der tager bisfosfonatbehandling for symptomatisk hypercalcæmi inden for de seneste 28 dage; brug af bisfosfonatbehandling af andre årsager (f.eks. knoglemetastaser eller osteoporose) er tilladt
Patienter med kendt malignitet i det primære centralnervesystem (CNS) eller symptomatiske CNS-metastaser er udelukket med følgende undtagelser:
- Patienter med asymptomatisk ubehandlet CNS-sygdom kan tilmeldes, forudsat at alle følgende kriterier er opfyldt:
  - Evaluerbar eller målbar sygdom uden for CNS
  - Ingen metastaser til hjernestammen, mellemhjernen, pons, medulla, lillehjernen eller inden for 10 mm fra det optiske apparat (optiske nerver og chiasme)
  - Ingen historie med intrakraniel blødning eller rygmarvsblødning
  - Intet løbende krav om dexamethason til CNS-sygdom; patienter på en stabil dosis af antikonvulsiva er tilladt
  - Ingen neurokirurgisk resektion eller hjernebiopsi inden for 28 dage før cyklus 1, dag 1
- Patienter med asymptomatisk behandlede CNS-metastaser kan tilmeldes, forudsat at alle ovennævnte kriterier er opfyldt samt følgende:
  - Radiografisk demonstration af forbedring efter afslutning af CNS-styret terapi og ingen tegn på midlertidig progression mellem afslutningen af CNS-styret terapi og screening-radiografisk undersøgelse
  - Ingen stereotaktisk stråling eller helhjernestråling inden for 28 dage før cyklus 1, dag 1
  - Screening CNS radiografisk undersøgelse >= 4 uger fra afslutning af strålebehandling og >= 2 uger fra seponering af kortikosteroider
Kendt overfølsomhed over for ovariecelleprodukter fra kinesisk hamster eller andre rekombinante humane antistoffer
Anamnese med alvorlige allergiske, anafylaktiske eller andre overfølsomhedsreaktioner over for kimære eller humaniserede antistoffer eller fusionsproteiner
Patienter, der har behov for behandling med en receptoraktivator af nuklear faktor kappa-B-ligand (RANKL) hæmmer (f. denosumab), som ikke kan seponere det før behandling med atezolizumab
Kendt klinisk signifikant leversygdom, herunder aktiv viral, alkoholisk eller anden hepatitis; skrumpelever; fed lever; og arvelig leversygdom
- Patienter med tidligere eller løst hepatitis B-infektion (defineret som at have en negativ hepatitis B overfladeantigen [HBsAg] test og en positiv anti-HBc [antistof mod hepatitis B kerneantigen] antistoftest) er kvalificerede
- Patienter, der er positive for hepatitis C-virus (HCV)-antistof, er kun kvalificerede, hvis polymerasekædereaktion (PCR) er negativ for HCV-ribonukleinsyre (RNA)
Anamnese eller risiko for autoimmun sygdom, herunder men ikke begrænset til systemisk lupus erythematosus, reumatoid arthritis, inflammatorisk tarmsygdom, vaskulær trombose forbundet med antiphospholipid syndrom, Wegeners granulomatose, Sjogrens syndrom, Guillain-Barre syndrom, multipel sygdom, vaskulitis, autoimmun sygdom, vaskulitis, eller glomerulonefritis (20/02/2019)
- Patienter med en anamnese med autoimmun hypothyroidisme på en stabil dosis af thyreoideaerstatningshormon er kvalificerede
- Patienter med kontrolleret type 1-diabetes mellitus på en stabil insulinkur eller type 2-diabetes mellitus er kvalificerede
- Patienter med eksem, psoriasis, lichen simplex chronicus eller vitiligo med kun dermatologiske manifestationer (f.eks. vil patienter med psoriasisgigt blive udelukket) er tilladt, forudsat at de opfylder følgende betingelser:
  - Patienter med psoriasis skal have en baseline oftalmologisk undersøgelse for at udelukke okulære manifestationer
  - Udslæt skal dække mindre end 10 % af kropsoverfladen (BSA)
  - Sygdommen er velkontrolleret ved baseline og kræver kun topikale steroider med lav styrke (f.eks. hydrocortison 2,5 %, hydrocortisonbutyrat 0,1 %, fluocinolon 0,01 %, desonid 0,05 %, alclometasondipropionat 0,05 %)
  - Ingen akutte forværringer af den underliggende tilstand inden for de sidste 12 måneder (kræver ikke psoralen plus ultraviolet A-stråling [PUVA], methotrexat, retinoider, biologiske midler, orale calcineurinhæmmere; høj styrke eller orale steroider)
Anamnese med idiopatisk lungefibrose, lungebetændelse (herunder lægemiddelinduceret), organiserende lungebetændelse (dvs. bronchiolitis obliterans, kryptogene organiserende lungebetændelse osv.) eller tegn på aktiv lungebetændelse ved screening af brysttomografi (CT) scanning; anamnese med strålingspneumonitis i strålefeltet (fibrose) er tilladt
Patienter med aktiv tuberkulose (TB) er udelukket
Alvorlige infektioner inden for 4 uger før cyklus 1, dag 1, inklusive men ikke begrænset til hospitalsindlæggelse for komplikationer af infektion, bakteriæmi eller svær lungebetændelse
Tegn eller symptomer på infektion inden for 2 uger før cyklus 1, dag 1
Modtaget oral eller intravenøs (IV) antibiotika inden for 2 uger før cyklus 1, dag 1; patienter, der får profylaktisk antibiotika (f.eks. til forebyggelse af en urinvejsinfektion eller kronisk obstruktiv lungesygdom) er berettigede
Større kirurgisk indgreb inden for 28 dage før cyklus 1, dag 1 eller forventning om behov for et større kirurgisk indgreb i løbet af undersøgelsen
Administration af en levende, svækket vaccine inden for 4 uger før cyklus 1, dag 1 eller forventning om, at en sådan levende, svækket vaccine vil være påkrævet under undersøgelsen og op til 5 måneder efter den sidste dosis atezolizumab (29/06/2017)
- Influenzavaccination bør kun gives i influenzasæsonen (ca. oktober til marts); patienter må ikke modtage levende, svækket influenzavaccine inden for 4 uger før cyklus 1, dag 1 eller på noget tidspunkt under undersøgelsen
Ukontrolleret interkurrent sygdom, herunder, men ikke begrænset til, igangværende eller aktiv infektion, symptomatisk kongestiv hjertesvigt, ustabil angina pectoris, hjertearytmi eller psykiatrisk sygdom/sociale situationer, der ville begrænse overholdelse af undersøgelseskrav
Human immundefektvirus (HIV)-inficerede patienter i effektiv antiretroviral behandling med upåviselig viral belastning inden for 6 måneder er kvalificerede til dette forsøg (08-JAN-2021)
Tidligere invasiv malignitet (undtagen ikke-melanomatøs hudkræft), medmindre sygdomsfri i mindst 3 år, med undtagelse af dem med en ubetydelig risiko for metastaser eller død, såsom carcinom in situ i brystet eller livmoderhalsen
Alvorlig, aktiv komorbiditet defineret som følger:
- Aktuelle (inden for 28 dage efter cyklus 1, dag 1) tegn og/eller symptomer på tarmobstruktion
- Patienter, der har brug for forældrenes hydrering og/eller ernæring
- Patienter, der har behov for dræning af gastrostomisonde
- Tegn på blødende diatese eller klinisk signifikant koagulopati
- Alvorligt, ikke-helende eller afskrækkende sår, aktivt sår eller ubehandlet knoglebrud
- Anamnese med hæmoptyse (>= 1/2 teskefuld lyserødt blod pr. episode) inden for 1 måned efter studietilmelding
Betydelig kardiovaskulær eller cerebrovaskulær sygdom, herunder:
- Ukontrolleret hypertension (systolisk blodtryk [SBP] >= 150 og/eller diastolisk blodtryk [DBP] >= 90)
- Anamnese med myokardieinfarkt inden for 6 måneder
- Ustabil angina
- New York Heart Association funktionel klassifikation II, III eller IV
- Baseline ejektionsfraktion =< 50 % vurderet ved ekkokardiogram eller multi-gated acquisition (MUGA)
- Cerebral vaskulær ulykke (CVA) eller forbigående iskæmisk anfald (TIA) inden for 6 måneder
- Betydelig vaskulær sygdom (f.eks. aortaaneurisme, der kræver kirurgisk reparation eller perifer arteriel trombose) inden for 6 måneder
Anamnese med abdominal/bækken eller trakeøsofageal fistel eller gastrointestinal perforation og/eller abdominal/bækken absces inden for 6 måneder før påbegyndelse af behandling (20/02/2019)
Gravide eller ammende patienter

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Arm I (PLD, atezolizumab) Patienter modtager pegyleret liposomalt doxorubicinhydrochlorid IV over 60 minutter på dag 1 og atezolizumab IV over 30-60 minutter på dag 1 og 15. (Lukket for optjening fra den 9. februar 2021)	Andet: Livskvalitetsvurdering Hjælpestudier Andre navne: Livskvalitetsvurdering Medicin: Pegyleret liposomalt doxorubicinhydrochlorid Givet IV Andre navne: ATI-0918 Caelyx Doxil Doxilen Doxorubicin HCl liposom Duomeisu Evacet LipoDox Liposomal Adriamycin Liposomal-indkapslet doxorubicin Pegyleret doxorubicin HCl liposom S-liposomal doxorubicin Stealth Liposomal Doxorubicin TLC D-99 Dox-SL Doxorubicin HCl Liposomal Doxorubicin hydrochlorid liposom Lipodox 50 Liposomal doxorubicin hydrochlorid Pegyleret liposomalt doxorubicin Doxorubicin liposomal Procedure: Computertomografi Gennemgå CT Andre navne: CT KAT CAT-scanning Beregnet aksial tomografi Computerstyret aksial tomografi Computerstyret tomografi CT-scanning tomografi Computerstyret aksial tomografi (procedure) Computerstyret tomografi (CT) scanning Diagnostisk CAT -scanning Diagnostic CAT Scan Service Type Medicin: Atezolizumab Givet IV Andre navne: Tecentriq MPDL3280A RO5541267 RG7446 MPDL 3280A MPDL 328OA MPDL-3280A MPDL328OA RG-7446 RG 7446 RO 5541267 RO-5541267
Eksperimentel: Arm II (PLD, bevacizumab, atezolizumab) Patienterne får pegyleret liposomalt doxorubicinhydrochlorid IV over 60 minutter på dag 1, bevacizumab IV over 30-90 minutter på dag 1 og 15 og atezolizumab IV over 30-60 minutter på dag 1 og 15. Patienterne gennemgår også CT ved undersøgelse.	Andet: Livskvalitetsvurdering Hjælpestudier Andre navne: Livskvalitetsvurdering Medicin: Pegyleret liposomalt doxorubicinhydrochlorid Givet IV Andre navne: ATI-0918 Caelyx Doxil Doxilen Doxorubicin HCl liposom Duomeisu Evacet LipoDox Liposomal Adriamycin Liposomal-indkapslet doxorubicin Pegyleret doxorubicin HCl liposom S-liposomal doxorubicin Stealth Liposomal Doxorubicin TLC D-99 Dox-SL Doxorubicin HCl Liposomal Doxorubicin hydrochlorid liposom Lipodox 50 Liposomal doxorubicin hydrochlorid Pegyleret liposomalt doxorubicin Doxorubicin liposomal Procedure: Computertomografi Gennemgå CT Andre navne: CT KAT CAT-scanning Beregnet aksial tomografi Computerstyret aksial tomografi Computerstyret tomografi CT-scanning tomografi Computerstyret aksial tomografi (procedure) Computerstyret tomografi (CT) scanning Diagnostisk CAT -scanning Diagnostic CAT Scan Service Type Biologisk: Bevacizumab Givet IV Andre navne: Avastin ABP 215 Anti-VEGF Anti-VEGF humaniseret monoklonalt antistof Anti-VEGF monoklonalt antistof SIBP04 Anti-VEGF rhuMAb Bevacizumab awwb Bevacizumab Biosimilar ABP 215 Bevacizumab Biosimilar BEVZ92 Bevacizumab Biosimilar BI 695502 Bevacizumab Biosimilar CBT 124 Bevacizumab Biosimilar CT-P16 Bevacizumab Biosimilar FKB238 Bevacizumab Biosimilar GB-222 Bevacizumab Biosimilar HD204 Bevacizumab Biosimilar HLX04 Bevacizumab Biosimilar IBI305 Bevacizumab Biosimilar LY01008 Bevacizumab Biosimilar MIL60 Bevacizumab Biosimilar Mvasi Bevacizumab Biosimilar MYL-1402O Bevacizumab Biosimilar QL 1101 Bevacizumab Biosimilar RPH-001 Bevacizumab Biosimilar SCT501 Bevacizumab Biosimilar Zirabev Bevacizumab-awwb Bevacizumab-bvzr BP102 BP102 Biosimilar HD204 Immunoglobulin G1 (human-mus monoklonal rhuMab-VEGF gammakæde anti-human vaskulær endotelvækstfaktor), disulfid med human-mus monoklonal rhuMab-VEGF let kæde, dimer Mvasi MYL-1402O Rekombinant humaniseret anti-VEGF monoklonalt antistof rhuMab-VEGF SCT501 SIBP 04 SIBP-04 SIBP04 Zirabev QL1101 Bevacizumab Biosimilar QL1101 BAT1706 BAT 1706 BAT-1706 BAT1706 Biosimilar Bevacizumab Biosimilar BAT1706 Bevacizumab-adcd CT-P16 Vegzelma Alymsys ABP-215 ABP215 Aybintio Bevacizumab-aybi Bevacizumab-equi Bevacizumab-maly Bevacizumab-onbe CT P16 CTP16 Ensartet Onbevzi Avzivi Bevacizumab Biosimilar MB02 Bevacizumab-tnjn FKB 238 FKB-238 FKB238 MB 02 MB-02 MB02 Oyavas PF 06439535 PF-06439535 PF06439535 Medicin: Atezolizumab Givet IV Andre navne: Tecentriq MPDL3280A RO5541267 RG7446 MPDL 3280A MPDL 328OA MPDL-3280A MPDL328OA RG-7446 RG 7446 RO 5541267 RO-5541267
Aktiv komparator: Arm III (PLD, bevacizumab) Patienterne får pegyleret liposomalt doxorubicinhydrochlorid IV over 60 minutter på dag 1 og bevacizumab IV over 30-90 minutter på dag 1 og 15. Patienterne gennemgår også CT ved undersøgelse.	Andet: Livskvalitetsvurdering Hjælpestudier Andre navne: Livskvalitetsvurdering Medicin: Pegyleret liposomalt doxorubicinhydrochlorid Givet IV Andre navne: ATI-0918 Caelyx Doxil Doxilen Doxorubicin HCl liposom Duomeisu Evacet LipoDox Liposomal Adriamycin Liposomal-indkapslet doxorubicin Pegyleret doxorubicin HCl liposom S-liposomal doxorubicin Stealth Liposomal Doxorubicin TLC D-99 Dox-SL Doxorubicin HCl Liposomal Doxorubicin hydrochlorid liposom Lipodox 50 Liposomal doxorubicin hydrochlorid Pegyleret liposomalt doxorubicin Doxorubicin liposomal Procedure: Computertomografi Gennemgå CT Andre navne: CT KAT CAT-scanning Beregnet aksial tomografi Computerstyret aksial tomografi Computerstyret tomografi CT-scanning tomografi Computerstyret aksial tomografi (procedure) Computerstyret tomografi (CT) scanning Diagnostisk CAT -scanning Diagnostic CAT Scan Service Type Biologisk: Bevacizumab Givet IV Andre navne: Avastin ABP 215 Anti-VEGF Anti-VEGF humaniseret monoklonalt antistof Anti-VEGF monoklonalt antistof SIBP04 Anti-VEGF rhuMAb Bevacizumab awwb Bevacizumab Biosimilar ABP 215 Bevacizumab Biosimilar BEVZ92 Bevacizumab Biosimilar BI 695502 Bevacizumab Biosimilar CBT 124 Bevacizumab Biosimilar CT-P16 Bevacizumab Biosimilar FKB238 Bevacizumab Biosimilar GB-222 Bevacizumab Biosimilar HD204 Bevacizumab Biosimilar HLX04 Bevacizumab Biosimilar IBI305 Bevacizumab Biosimilar LY01008 Bevacizumab Biosimilar MIL60 Bevacizumab Biosimilar Mvasi Bevacizumab Biosimilar MYL-1402O Bevacizumab Biosimilar QL 1101 Bevacizumab Biosimilar RPH-001 Bevacizumab Biosimilar SCT501 Bevacizumab Biosimilar Zirabev Bevacizumab-awwb Bevacizumab-bvzr BP102 BP102 Biosimilar HD204 Immunoglobulin G1 (human-mus monoklonal rhuMab-VEGF gammakæde anti-human vaskulær endotelvækstfaktor), disulfid med human-mus monoklonal rhuMab-VEGF let kæde, dimer Mvasi MYL-1402O Rekombinant humaniseret anti-VEGF monoklonalt antistof rhuMab-VEGF SCT501 SIBP 04 SIBP-04 SIBP04 Zirabev QL1101 Bevacizumab Biosimilar QL1101 BAT1706 BAT 1706 BAT-1706 BAT1706 Biosimilar Bevacizumab Biosimilar BAT1706 Bevacizumab-adcd CT-P16 Vegzelma Alymsys ABP-215 ABP215 Aybintio Bevacizumab-aybi Bevacizumab-equi Bevacizumab-maly Bevacizumab-onbe CT P16 CTP16 Ensartet Onbevzi Avzivi Bevacizumab Biosimilar MB02 Bevacizumab-tnjn FKB 238 FKB-238 FKB238 MB 02 MB-02 MB02 Oyavas PF 06439535 PF-06439535 PF06439535

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Forekomst af dosisbegrænsende toksiciteter (DLT) af eksperimentelle regimer Tidsramme: Op til 28 dage	Vil blive klassificeret ved hjælp af fælles terminologikriterier for bivirkninger (CTCAE) version (V) 4.0 (CTCAE version 5.0 vil blive brugt fra 1. april 2018). DLT vurderes.	Op til 28 dage
Progression Free Survival (PFS) (fase II) Tidsramme: Fra studietilmelding til efterforskeren bestemte datoen for progression eller død på grund af enhver årsag, alt efter hvad der først sker, vurderet op til 5 år	Vil blive vurderet efter responsevalueringskriterier i faste tumorer (RECIST) V1.1-kriterier og vil omfatte estimater af fareforholdene og de tilsvarende konfidensintervaller for den eksperimentelle regime i forhold til referenceprogrammet såvel som Kaplan-Meier-estimater af overlevelsesfunktionen for hver behandlingsgruppe. Progression defineres med en stigning på 20% i summen af den længste diameter af mållæsioner og en 5 mm absolut stigning fra nadir eller en utvetydig stigning i en ikke-mållæsion eller udseendet af nye læsioner.	Fra studietilmelding til efterforskeren bestemte datoen for progression eller død på grund af enhver årsag, alt efter hvad der først sker, vurderet op til 5 år
PFS (fase III) Tidsramme: Fra undersøgelsesregistrering til efterforskeren bestemte datoen for progression eller død på grund af enhver årsag, alt efter hvad der først forekommer, vurderet op til 5 år.	Vil blive vurderet efter RECIST V1.1-kriterier og vil omfatte estimater af fareforholdene og de tilsvarende konfidensintervaller for det eksperimentelle regime i forhold til referencebeløbet såvel som Kaplan-Meier-estimater af overlevelsesfunktionen for hver behandlingsgruppe. Progression defineres med en stigning på 20% i summen af den længste diameter af mållæsioner og en 5 mm absolut stigning fra nadir eller en utvetydig stigning i en ikke-mållæsion eller udseendet af nye læsioner.	Fra undersøgelsesregistrering til efterforskeren bestemte datoen for progression eller død på grund af enhver årsag, alt efter hvad der først forekommer, vurderet op til 5 år.
Samlet overlevelse (OS) (fase III) Tidsramme: Fra undersøgelsesregistrering til dødsdatoen uanset årsagen, vurderet op til 5 år	OS evalueres ved Kaplan Meier -metoder. Medianoverlevelse og konfidensintervaller vil blive rapporteret.	Fra undersøgelsesregistrering til dødsdatoen uanset årsagen, vurderet op til 5 år

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Objektiv svarprocent (ORR) (delvis eller komplet respons) (fase II) Tidsramme: Op til 5 år	Vurderes efter RECIST V1.1 -kriterier. Vil blive tabuleret af behandlingsgruppen og 95% konfidensintervaller præsenteret ved hjælp af Wilsons score -metode. Behandlingsarme sammenlignes ved hjælp af en sandsynlighedsforhold Chi-square-test. Progression defineres med en stigning på 20% i summen af den længste diameter af mållæsioner og en 5 mm absolut stigning fra nadir eller en utvetydig stigning i en ikke-mållæsion eller udseende af nye læsioner. Til definitionen af respons: Svarene vurderes som den samlede bedste respons i løbet af terapien. For delvis respons (PR) skal summen af de længste diametre falde med mindst 30%. For en komplet respons (CR) skal alt bevis for sygdom være væk, og CA125 -niveauerne skal normalisere. Hvis en patient oplever en sygdomsprogression under behandlingen, klassificeres dette som progressiv sygdom (PD). Hvis patienten hverken skrider frem (PD) eller har en respons (CR eller PR), klassificeres patienten som stabil sygdom (SD).	Op til 5 år
Orr (delvis eller komplet respons) (fase III) Tidsramme: Op til 5 år	Vil blive vurderet af RECIST V1.1. Vil blive tabuleret af behandlingsgruppen, og 95% konfidensintervaller vil blive præsenteret ved hjælp af Wilsons score -metode. Behandlingsarme sammenlignes ved hjælp af en sandsynlighedsforhold Chi-square-test. Progression defineres med en stigning på 20% i summen af den længste diameter af mållæsioner og en 5 mm absolut stigning fra nadir eller en utvetydig stigning i en ikke-mållæsion eller udseendet af nye læsioner. Til definitionen af respons: Svarene vurderes som den samlede bedste respons i løbet af terapien. For delvis respons (PR) skal summen af de længste diametre falde med mindst 30%. For en komplet respons (CR) skal alt bevis for sygdom være væk, og CA125 -niveauerne skal normalisere. Hvis en patient oplever en sygdomsprogression under behandlingen, klassificeres dette som progressiv sygdom (PD). Hvis patienten hverken skrider frem (PD) eller har en respons (CR eller PR), klassificeres patienten som stabil sygdom (SD).	Op til 5 år
Antal patienter med en grad 3 (eller højere) bivirkning (fase II) Tidsramme: Op til 5 år	CTCAE V5.0 blev brugt til at klassificere bivirkninger. Dette slutpunkt vil tabulere antallet af patienter, der rapporterede mindst en bivirkning af en grad 3 (eller højere).	Op til 5 år
Antal patienter med en grad 3 (eller højere) bivirkning (fase III) Tidsramme: Op til 5 år	CTCAE V5.0 blev brugt til at klassificere bivirkninger. Dette slutpunkt vil tabulere antallet af patienter, der rapporterede mindst en bivirkning af en grad 3 (eller højere).	Op til 5 år
Patienten rapporterede resultater Tidsramme: Op til 2 år	Patientens rapporterede resultater måles med NFOSI-18 sygdomsrelaterede fysiske symptomer underskala (DRS-P). DRS-P-underskalaen omfatter 9 poster med hvert emne, der spænder fra 0 til 4. Den samlede score for DRS-P-underskalaen varierer 0-36 med en større score, der antyder foretrukne/bedre sundhedsstater.	Op til 2 år

Andre resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Ændringer i kvantitative biomarkørparametre i væv, blod og afføring Tidsramme: Baseline op til 12 uger	Ændringer i kvantitative biomarkørparametre i væv, blod og afføring vil blive vurderet.	Baseline op til 12 uger

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

National Cancer Institute (NCI)

Samarbejdspartnere

NRG Oncology

Efterforskere

Ledende efterforsker: Roisin E O'Cearbhaill, NRG Oncology

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Gaitskell K, Rogozinska E, Platt S, Chen Y, Abd El Aziz M, Tattersall A, Morrison J. Angiogenesis inhibitors for the treatment of epithelial ovarian cancer. Cochrane Database Syst Rev. 2023 Apr 18;4(4):CD007930. doi: 10.1002/14651858.CD007930.pub3.

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

23. juni 2017

Primær færdiggørelse (Faktiske)

9. maj 2023

Studieafslutning (Anslået)

11. maj 2027

Datoer for studieregistrering

Først indsendt

20. juli 2016

Først indsendt, der opfyldte QC-kriterier

20. juli 2016

Først opslået (Anslået)

21. juli 2016

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

1. juni 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

29. maj 2026

Sidst verificeret

1. maj 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

NCI-2016-01081 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
U10CA180868 (U.S. NIH-bevilling/kontrakt)
NRG-GY009 (Anden identifikator: CTEP)

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

produkt fremstillet i og eksporteret fra U.S.A.

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Livskvalitetsvurdering

Seoul National University Hospital

Trukket tilbage

Virkninger af præoperativ angst og depression på kortsigtet postoperativ restitution ved tidlig gastrisk cancer

Depression | Postoperative komplikationer | Angst | Mestringsadfærd

Korea, Republikken
Memorial Sloan Kettering Cancer Center

Afsluttet

Indvirkning af palliativ kateterplacering på livskvaliteten for patienter med refraktær ascites

Ascites

Forenede Stater
Latin American Cooperative Oncology Group
Roche Pharma AG; EVA - Grupo Brasileiro de Tumores Ginecológicos

Afsluttet

Prospektiv evaluering af patienter med livmoderhalskræft i brasilianske sundhedsinstitutioner - EVITA I-undersøgelsen

Livmoderhalskræft

Brasilien
Ankara University

Afsluttet

ValideringTurkishVersionQualityofRecovery-15 (ValidQoR-15)

Større abdominal kirurgi | Patientrapporteret resultat

Kalkun
Kutahya Health Sciences University

Afsluttet

Tyrkisk gyldighed og pålidelighed af smertekatastrofiserende scale-Child (PCS-C)

Kronisk smerte | Juvenil idiopatisk arthritis

Kalkun
University of Florida

Afsluttet

Medlidenhedstræthed hos ED-udbydere

Medfølelse Træthed

Forenede Stater
World Vision Canada
Ryerson University; World Health Organization; Global Affairs Canada; Ministry...

Afsluttet

Klinisk evaluering af brugen af en mHealth-intervention om plejekvalitet

Diarré | Malaria | Akut luftvejsinfektion
Maastricht University
TNO; Netherlands Instititute for Health Services Research; University of...

Afsluttet

Effektivitet og implementering af værktøjet til vurdering af byrde ved kroniske lidelser (ABCC)

Hjertefejl | Diabetes mellitus, type 2 | Kronisk obstruktiv lungesygdom | Astma

Holland
University Hospital, Strasbourg, France

Afsluttet

Validering af en pædiatrisk billedversion af QOR-15 Postoperatory Functional Recovery Scale - QoR-15 Pédiatric

Kirurgisk indgreb | Mindre

Frankrig
King's College London
Guy's and St Thomas' NHS Foundation Trust

Afsluttet

Livskvalitetsværktøj til IBD (QOLITI)

Inflammatorisk tarmsygdom

Det Forenede Kongerige

Pegyleret liposomalt doxorubicinhydrochlorid med atezolizumab og/eller bevacizumab til behandling af patienter med tilbagevendende kræft i æggestokkene, æggelederen eller primær peritoneal cancer

Et randomiseret, fase II/III-studie af pegyleret liposomalt doxorubicin og CTEP-leveret atezolizumab versus pegyleret liposomalt doxorubicin, CTEP-leveret bevacizumab og CTEP-leveret atezolizumab versus pegyleret liposomalt liposomalt doxorubicin og CTEP-leveret bevacizumab og CTEP-leveret

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Andre resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Publikationer og nyttige links

Generelle publikationer

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Faktiske)

Studieafslutning (Anslået)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Anslået)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

produkt fremstillet i og eksporteret fra U.S.A.

Kliniske forsøg med Livskvalitetsvurdering

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Mexico

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer