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Lung-MAP: AZD4547 som andenlinjeterapi til behandling af FGFR-positive patienter med tilbagevendende trin IV planocellulær lungekræft

25. maj 2021 opdateret af: Southwest Oncology Group

Et fase II-studie af AZD4547 for tidligere behandlede FGFR-positive patienter med trin IV planocellulært lungekræft (Lung-Map Sub-studie)

Dette fase II/III-forsøg undersøger, hvor godt FGFR-hæmmeren AZD4547 (AZD4547) virker ved behandling af patienter med stadium IV planocellulær lungekræft, som er kommet tilbage efter tidligere behandling. Dette er et delstudie, der omfatter alle screenede patienter, der er positive for biomarkøren for fibroblast growth factor receptor (FGFR). FGFR kan få tumorceller til at vokse hurtigere. AZD4547 kan nedsætte aktiviteten af FGFR og kan være i stand til at formindske tumorer.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆRE MÅL:

I. At evaluere, om der er tilstrækkelig evidens for at fortsætte til fase III-komponenten ved at evaluere den objektive responsrate (ORR) med AZD4547 hos FGFR-positive patienter. (Fase II) II. Hvis undersøgelsen opfylder kriterierne specificeret i S1400, vil undersøgelsen blive ændret til at omfatte et opfølgende randomiseret fase III-forsøg. (Fase III)

SEKUNDÆRE MÅL:

I. At evaluere investigator-vurderet progressionsfri overlevelse (IA-PFS) og samlet overlevelse (OS) hos FGFR-positive patienter behandlet med AZD4547. (Fase II) II. For at evaluere varigheden af respons (DoR) blandt FGFR-positive patienter behandlet med AZD4547, som opnår et komplet respons (CR) eller delvis respons (PR) (bekræftet og ubekræftet) ved responsevalueringskriterier i solide tumorer (RECIST) 1.1. (Fase II) III. At evaluere hyppigheden og sværhedsgraden af toksiciteter forbundet med AZD4547 hos FGFR-positive patienter. (Fase II)

MÅL FOR TRANSLATIONEL MEDICIN:

I. At identificere yderligere prædiktive tumor-/blod-biomarkører, der kan modificere respons eller definere resistens over for AZD4547 ud over den valgte biomarkør til biomarkør-drevne delstudier.

II. At identificere potentielle resistensbiomarkører ved sygdomsprogression. III. At etablere et vævs-/blodlager fra patienter med refraktært planocellulært karcinom (SCCA) i lungen.

OVERSIGT: Fra 18.12.2015 er patienterne tildelt Arm I.

ARM I: Patienter får FGFR-hæmmer AZD4547 oralt (PO) to gange dagligt (BID) på dag 1-21. Kurser gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.

ARM II (LUKKET FOR OPDATERING 12/18/2015): Patienter får docetaxel intravenøst (IV) på dag 1. Kurser gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet. Efter progression kan patienter være berettiget til at omregistrere sig til arm III.

ARM III: Patienter i Arm II, der er kvalificeret til genregistrering, modtager FGFR-hæmmer AZD4547 PO BID på dag 1-21. Kurser gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.

Efter afsluttet studiebehandling følges alle patienter op hver 6. måned i de første 2 år og derefter i slutningen af år 3 fra dato for delstudie/genregistrering.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

Fase

Fase 2
Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Canada
- Ontario
  - Toronto, Ontario, Canada, M5G 2M9
    - University Health Network-Princess Margaret Hospital
Forenede Stater
- Alabama
  - Birmingham, Alabama, Forenede Stater, 35233
    - University of Alabama at Birmingham Cancer Center
- Alaska
  - Anchorage, Alaska, Forenede Stater, 98508
    - Anchorage Associates in Radiation Medicine
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Oncology and Hematology LLC
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Women's Cancer Care
  - Anchorage, Alaska, Forenede Stater, 99508
    - Anchorage Oncology Centre
  - Anchorage, Alaska, Forenede Stater, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, Forenede Stater, 99508
    - Providence Alaska Medical Center
  - Anchorage, Alaska, Forenede Stater, 99504
    - Anchorage Radiation Therapy Center
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Regional Hospital
  - Fairbanks, Alaska, Forenede Stater, 99701
    - Fairbanks Memorial Hospital
- Arizona
  - Tucson, Arizona, Forenede Stater, 85719
    - University of Arizona Cancer Center-North Campus
  - Tucson, Arizona, Forenede Stater, 85724
    - The University of Arizona Medical Center-University Campus
  - Yuma, Arizona, Forenede Stater, 85364
    - Yuma Cancer Center
- Arkansas
  - Hot Springs, Arkansas, Forenede Stater, 71913
    - Mercy Cancer Center-Hot Springs
  - Jonesboro, Arkansas, Forenede Stater, 72401
    - Fowler Family Center for Cancer Care
  - Little Rock, Arkansas, Forenede Stater, 72205
    - University of Arkansas for Medical Sciences
- California
  - Anaheim, California, Forenede Stater, 92807
    - Kaiser Permanente-Anaheim
  - Antioch, California, Forenede Stater, 94531
    - Kaiser Permanente-Deer Valley Medical Center
  - Auburn, California, Forenede Stater, 95602
    - Sutter Auburn Faith Hospital
  - Auburn, California, Forenede Stater, 95603
    - Sutter Cancer Centers Radiation Oncology Services-Auburn
  - Bakersfield, California, Forenede Stater, 93301
    - AIS Cancer Center at San Joaquin Community Hospital
  - Baldwin Park, California, Forenede Stater, 91706
    - Kaiser Permanente-Baldwin Park
  - Bellflower, California, Forenede Stater, 90706
    - Kaiser Permanente-Bellflower
  - Berkeley, California, Forenede Stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burbank, California, Forenede Stater, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Burlingame, California, Forenede Stater, 94010
    - Mills-Peninsula Medical Center
  - Cameron Park, California, Forenede Stater, 95682
    - Sutter Cancer Centers Radiation Oncology Services-Cameron Park
  - Castro Valley, California, Forenede Stater, 94546
    - Eden Hospital Medical Center
  - Corona, California, Forenede Stater, 92879
    - City of Hope Corona
  - Davis, California, Forenede Stater, 95616
    - Sutter Davis Hospital
  - Duarte, California, Forenede Stater, 91010
    - City of Hope Comprehensive Cancer Center
  - Fontana, California, Forenede Stater, 92335
    - Kaiser Permanente Hospital
  - Fremont, California, Forenede Stater, 94538
    - Kaiser Permanente-Fremont
  - Fresno, California, Forenede Stater, 93720
    - Kaiser Permanente
  - Fullerton, California, Forenede Stater, 92835
    - Saint Jude Medical Center
  - Harbor City, California, Forenede Stater, 90710
    - Kaiser Permanente - Harbor City
  - Irvine, California, Forenede Stater, 92618
    - Kaiser Permanente-Irvine
  - La Jolla, California, Forenede Stater, 92093
    - UC San Diego Moores Cancer Center
  - Lancaster, California, Forenede Stater, 93534
    - City of Hope Antelope Valley
  - Loma Linda, California, Forenede Stater, 92354
    - Loma Linda University Medical Center
  - Los Angeles, California, Forenede Stater, 90033
    - USC / Norris Comprehensive Cancer Center
  - Los Angeles, California, Forenede Stater, 90033
    - Los Angeles County-USC Medical Center
  - Los Angeles, California, Forenede Stater, 90027
    - Kaiser Permanente Los Angeles Medical Center
  - Los Angeles, California, Forenede Stater, 90034
    - Kaiser Permanente-Cadillac
  - Modesto, California, Forenede Stater, 95355
    - Memorial Medical Center
  - Modesto, California, Forenede Stater, 95356
    - Kaiser Permanente-Modesto
  - Monterey, California, Forenede Stater, 93940
    - Community Hospital of Monterey Peninsula
  - Monterey, California, Forenede Stater, 93940
    - Pacific Cancer Care-Monterey
  - Mountain View, California, Forenede Stater, 94040
    - Palo Alto Medical Foundation-Camino Division
  - Mountain View, California, Forenede Stater, 94040
    - Palo Alto Medical Foundation-Gynecologic Oncology
  - Novato, California, Forenede Stater, 94945
    - Sutter Cancer Research Consortium
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente-Oakland
  - Orange, California, Forenede Stater, 92868
    - Saint Joseph Hospital - Orange
  - Panorama City, California, Forenede Stater, 91402
    - Kaiser Permanente - Panorama City
  - Paradise, California, Forenede Stater, 95969
    - Feather River Cancer Center
  - Pismo Beach, California, Forenede Stater, 93449
    - PCR Oncology
  - Rancho Cucamonga, California, Forenede Stater, 91730
    - City of Hope Rancho Cucamonga
  - Rancho Mirage, California, Forenede Stater, 92270
    - Eisenhower Medical Center
  - Redwood City, California, Forenede Stater, 94063
    - Kaiser Permanente-Redwood City
  - Richmond, California, Forenede Stater, 94801
    - Kaiser Permanente-Richmond
  - Riverside, California, Forenede Stater, 92505
    - Kaiser Permanente-Riverside
  - Roseville, California, Forenede Stater, 95661
    - Kaiser Permanente-Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Cancer Centers Radiation Oncology Services-Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forenede Stater, 95816
    - Sutter Medical Center Sacramento
  - Sacramento, California, Forenede Stater, 95817
    - University of California Davis Comprehensive Cancer Center
  - Sacramento, California, Forenede Stater, 95823
    - Kaiser Permanente-South Sacramento
  - Sacramento, California, Forenede Stater, 95825
    - Kaiser Permanente - Sacramento
  - Saint Helena, California, Forenede Stater, 94574
    - Saint Helena Hospital
  - San Diego, California, Forenede Stater, 92120
    - Kaiser Permanente-San Diego Zion
  - San Diego, California, Forenede Stater, 92108
    - Kaiser Permanente-San Diego Mission
  - San Francisco, California, Forenede Stater, 94115
    - Kaiser Permanente-San Francisco
  - San Francisco, California, Forenede Stater, 94115
    - California Pacific Medical Center-Pacific Campus
  - San Jose, California, Forenede Stater, 95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Leandro, California, Forenede Stater, 94577
    - Kaiser Permanente San Leandro
  - San Marcos, California, Forenede Stater, 92069
    - Kaiser Permanente-San Marcos
  - San Rafael, California, Forenede Stater, 94903
    - Kaiser Permanente-San Rafael
  - Santa Clara, California, Forenede Stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Rosa, California, Forenede Stater, 95403
    - Kaiser Permanente-Santa Rosa
  - Santa Rosa, California, Forenede Stater, 95403
    - Sutter Pacific Medical Foundation
  - South Pasadena, California, Forenede Stater, 91030
    - City of Hope South Pasadena
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente-South San Francisco
  - Stockton, California, Forenede Stater, 95210
    - Kaiser Permanente-Stockton
  - Vacaville, California, Forenede Stater, 95688
    - Kaiser Permanente Medical Center-Vacaville
  - Vacaville, California, Forenede Stater, 95687
    - Northbay Cancer Center
  - Vacaville, California, Forenede Stater, 95687
    - Sutter Cancer Centers Radiation Oncology Services-Vacaville
  - Vallejo, California, Forenede Stater, 94589
    - Kaiser Permanente-Vallejo
  - Vallejo, California, Forenede Stater, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek, California, Forenede Stater, 94596
    - Kaiser Permanente-Walnut Creek
  - Whittier, California, Forenede Stater, 90602
    - Presbyterian Intercommunity Hospital
  - Woodland Hills, California, Forenede Stater, 91367
    - Kaiser Permanente
- Colorado
  - Aurora, Colorado, Forenede Stater, 80045
    - University of Colorado Hospital
  - Aurora, Colorado, Forenede Stater, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Forenede Stater, 80012
    - The Medical Center of Aurora
  - Boulder, Colorado, Forenede Stater, 80301
    - Boulder Community Hospital
  - Boulder, Colorado, Forenede Stater, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Rocky Mountain Cancer Centers-Penrose
  - Colorado Springs, Colorado, Forenede Stater, 80909
    - Memorial Hospital Central
  - Denver, Colorado, Forenede Stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forenede Stater, 80205
    - Kaiser Permanente-Franklin
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forenede Stater, 80218
    - SCL Health Saint Joseph Hospital
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Forenede Stater, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Forenede Stater, 80204
    - Denver Health Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Forenede Stater, 80222
    - Colorado Cancer Research Program NCORP
  - Durango, Colorado, Forenede Stater, 81301
    - Mercy Medical Center
  - Durango, Colorado, Forenede Stater, 81301
    - Southwest Oncology PC
  - Englewood, Colorado, Forenede Stater, 80113
    - Swedish Medical Center
  - Englewood, Colorado, Forenede Stater, 80113
    - Comprehensive Cancer Care and Research Institute of Colorado LLC
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Golden, Colorado, Forenede Stater, 80401
    - Mountain Blue Cancer Care Center
  - Golden, Colorado, Forenede Stater, 80401
    - National Jewish Health-Western Hematology Oncology
  - Greeley, Colorado, Forenede Stater, 80631
    - North Colorado Medical Center
  - Greenwood Village, Colorado, Forenede Stater, 80111
    - Rocky Mountain Cancer Centers-Greenwood Village
  - Lafayette, Colorado, Forenede Stater, 80026
    - Kaiser Permanente-Rock Creek
  - Lakewood, Colorado, Forenede Stater, 80228
    - Saint Anthony Hospital
  - Lakewood, Colorado, Forenede Stater, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Littleton, Colorado, Forenede Stater, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton, Colorado, Forenede Stater, 80122
    - Littleton Adventist Hospital
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Kaiser Permanente-Lone Tree
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Longmont, Colorado, Forenede Stater, 80501
    - Longmont United Hospital
  - Longmont, Colorado, Forenede Stater, 80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland, Colorado, Forenede Stater, 80539
    - McKee Medical Center
  - Parker, Colorado, Forenede Stater, 80138
    - Parker Adventist Hospital
  - Parker, Colorado, Forenede Stater, 80138
    - Rocky Mountain Cancer Centers-Parker
  - Pueblo, Colorado, Forenede Stater, 81004
    - Saint Mary Corwin Medical Center
  - Pueblo, Colorado, Forenede Stater, 81008
    - Rocky Mountain Cancer Centers - Pueblo
  - Thornton, Colorado, Forenede Stater, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Wheat Ridge, Colorado, Forenede Stater, 80033
    - SCL Health Lutheran Medical Center
- Connecticut
  - Danbury, Connecticut, Forenede Stater, 06810
    - Danbury Hospital
  - Derby, Connecticut, Forenede Stater, 06418
    - Smilow Cancer Hospital-Derby Care Center
  - Fairfield, Connecticut, Forenede Stater, 06824
    - Smilow Cancer Hospital Care Center-Fairfield
  - Guilford, Connecticut, Forenede Stater, 06437
    - Medical Oncology and Hematology Group PC-Guilford
  - Hartford, Connecticut, Forenede Stater, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Hartford, Connecticut, Forenede Stater, 06102
    - Hartford Hospital
  - Meriden, Connecticut, Forenede Stater, 06451
    - Midstate Medical Center
  - New Britain, Connecticut, Forenede Stater, 06050
    - The Hospital of Central Connecticut
  - New Haven, Connecticut, Forenede Stater, 06520
    - Yale University
  - New Haven, Connecticut, Forenede Stater, 06510
    - Smilow Cancer Center/Yale-New Haven Hospital
  - New Haven, Connecticut, Forenede Stater, 06511
    - Yale-New Haven Hospital Saint Raphael Campus
  - North Haven, Connecticut, Forenede Stater, 06473
    - Yale-New Haven Hospital North Haven Medical Center
  - Norwich, Connecticut, Forenede Stater, 06360
    - Eastern Connecticut Hematology and Oncology Associates
  - Orange, Connecticut, Forenede Stater, 06477
    - Smilow Cancer Hospital-Orange Care Center
  - Torrington, Connecticut, Forenede Stater, 06790
    - Charlotte Hungerford Hospital Center for Cancer Care
  - Trumbull, Connecticut, Forenede Stater, 06611
    - Smilow Cancer Hospital Care Center-Trumbull
  - Waterbury, Connecticut, Forenede Stater, 06708
    - Smilow Cancer Hospital-Waterbury Care Center
  - West Haven, Connecticut, Forenede Stater, 06516
    - Veterans Affairs Connecticut Healthcare System-West Haven Campus
- Delaware
  - Lewes, Delaware, Forenede Stater, 19958
    - Beebe Medical Center
  - Newark, Delaware, Forenede Stater, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Forenede Stater, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, Forenede Stater, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Forenede Stater, 19718
    - Christiana Care Health System-Christiana Hospital
  - Newark, Delaware, Forenede Stater, 19713
    - Christiana Gynecologic Oncology LLC
  - Newark, Delaware, Forenede Stater, 19713
    - Regional Hematology and Oncology PA
  - Rehoboth Beach, Delaware, Forenede Stater, 19971
    - Beebe Health Campus
  - Seaford, Delaware, Forenede Stater, 19973
    - Nanticoke Memorial Hospital
  - Wilmington, Delaware, Forenede Stater, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington, District of Columbia, Forenede Stater, 20007
    - MedStar Georgetown University Hospital
  - Washington, District of Columbia, Forenede Stater, 20016
    - Sibley Memorial Hospital
- Florida
  - Deerfield Beach, Florida, Forenede Stater, 33442
    - UM Sylvester Comprehensive Cancer Center at Deerfield Beach
  - Fort Lauderdale, Florida, Forenede Stater, 33308
    - Holy Cross Hospital
  - Hollywood, Florida, Forenede Stater, 33021
    - Memorial Regional Hospital/Joe DiMaggio Children's Hospital
  - Miami, Florida, Forenede Stater, 33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami Beach, Florida, Forenede Stater, 33140
    - Mount Sinai Medical Center
  - Ocala, Florida, Forenede Stater, 34471
    - Ocala Oncology Center
  - Pembroke Pines, Florida, Forenede Stater, 33028
    - Memorial Hospital West
  - Pensacola, Florida, Forenede Stater, 32504
    - Sacred Heart Hospital
  - Tampa, Florida, Forenede Stater, 33612
    - Moffitt Cancer Center
- Georgia
  - Albany, Georgia, Forenede Stater, 31701
    - Phoebe Putney Memorial Hospital
  - Athens, Georgia, Forenede Stater, 30607
    - University Cancer and Blood Center LLC
  - Atlanta, Georgia, Forenede Stater, 30308
    - Emory University Hospital Midtown
  - Atlanta, Georgia, Forenede Stater, 30309
    - Piedmont Hospital
  - Atlanta, Georgia, Forenede Stater, 30322
    - Emory University/Winship Cancer Institute
  - Atlanta, Georgia, Forenede Stater, 30342
    - Northside Hospital
  - Atlanta, Georgia, Forenede Stater, 30342
    - Saint Joseph's Hospital of Atlanta
  - Augusta, Georgia, Forenede Stater, 30912
    - Augusta University Medical Center
  - Columbus, Georgia, Forenede Stater, 31904
    - John B Amos Cancer Center
  - Cumming, Georgia, Forenede Stater, 30041
    - Northside Hospital-Forsyth
  - Decatur, Georgia, Forenede Stater, 30033
    - Dekalb Medical Center
  - Gainesville, Georgia, Forenede Stater, 30501
    - Northeast Georgia Medical Center-Gainesville
  - Macon, Georgia, Forenede Stater, 31201
    - Medical Center of Central Georgia
  - Rome, Georgia, Forenede Stater, 30165
    - Harbin Clinic Medical Oncology and Clinical Research
  - Savannah, Georgia, Forenede Stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Savannah, Georgia, Forenede Stater, 31404
    - Memorial University Medical Center
  - Savannah, Georgia, Forenede Stater, 31404
    - Summit Cancer Care-Memorial
  - Savannah, Georgia, Forenede Stater, 31405
    - Low Country Cancer Care Associates PC
  - Valdosta, Georgia, Forenede Stater, 31602
    - South Georgia Medical Center/Pearlman Cancer Center
- Hawaii
  - 'Aiea, Hawaii, Forenede Stater, 96701
    - Pali Momi Medical Center
  - 'Aiea, Hawaii, Forenede Stater, 96701
    - Hawaii Oncology Inc-Pali Momi
  - 'Ewa Beach, Hawaii, Forenede Stater, 96706
    - The Cancer Center of Hawaii-Leeward
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - The Cancer Center of Hawaii-Liliha
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forenede Stater, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Hawaii Cancer Care Inc-Liliha
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Kuakini Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Island Urology
  - Honolulu, Hawaii, Forenede Stater, 96819
    - Kaiser Permanente Moanalua Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Hawaii Cancer Care Inc-POB II
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Hawaii Oncology Inc-POB I
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Hawaii Oncology Inc-Kuakini
  - Lihue, Hawaii, Forenede Stater, 96766
    - Wilcox Memorial Hospital and Kauai Medical Clinic
- Idaho
  - Boise, Idaho, Forenede Stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Forenede Stater, 83712
    - Saint Luke's Mountain States Tumor Institute
  - Coeur d'Alene, Idaho, Forenede Stater, 83814
    - Kootenai Medical Center
  - Fruitland, Idaho, Forenede Stater, 83619
    - Saint Luke's Mountain States Tumor Institute - Fruitland
  - Lewiston, Idaho, Forenede Stater, 83501
    - Saint Joseph Regional Medical Center
  - Meridian, Idaho, Forenede Stater, 83642
    - Saint Luke's Mountain States Tumor Institute - Meridian
  - Nampa, Idaho, Forenede Stater, 83686
    - Saint Luke's Mountain States Tumor Institute - Nampa
  - Post Falls, Idaho, Forenede Stater, 83854
    - Kootenai Cancer Center
  - Sandpoint, Idaho, Forenede Stater, 83864
    - Kootenai Cancer Clinic
  - Twin Falls, Idaho, Forenede Stater, 83301
    - Saint Luke's Mountain States Tumor Institute-Twin Falls
- Illinois
  - Aurora, Illinois, Forenede Stater, 60504
    - Rush - Copley Medical Center
  - Bloomington, Illinois, Forenede Stater, 61704
    - Illinois CancerCare-Bloomington
  - Bloomington, Illinois, Forenede Stater, 61701
    - Saint Joseph Medical Center
  - Canton, Illinois, Forenede Stater, 61520
    - Illinois CancerCare-Canton
  - Carthage, Illinois, Forenede Stater, 62321
    - Illinois CancerCare-Carthage
  - Centralia, Illinois, Forenede Stater, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Forenede Stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forenede Stater, 60612
    - Rush University Medical Center
  - Chicago, Illinois, Forenede Stater, 60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago, Illinois, Forenede Stater, 60612
    - John H Stroger Jr Hospital of Cook County
  - Chicago, Illinois, Forenede Stater, 60608
    - Mount Sinai Hospital Medical Center
  - Chicago, Illinois, Forenede Stater, 60625
    - Swedish Covenant Hospital
  - Danville, Illinois, Forenede Stater, 61832
    - Carle on Vermilion
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forenede Stater, 62526
    - Cancer Care Center of Decatur
  - Effingham, Illinois, Forenede Stater, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Forenede Stater, 62401
    - Carle Physician Group-Effingham
  - Eureka, Illinois, Forenede Stater, 61530
    - Illinois CancerCare-Eureka
  - Evanston, Illinois, Forenede Stater, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Evanston, Illinois, Forenede Stater, 60202
    - Saint Francis Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare-Galesburg
  - Geneva, Illinois, Forenede Stater, 60134
    - Northwestern Medicine Cancer Center Delnor
  - Glenview, Illinois, Forenede Stater, 60026
    - NorthShore University HealthSystem-Glenbrook Hospital
  - Harvey, Illinois, Forenede Stater, 60426
    - Ingalls Memorial Hospital
  - Highland Park, Illinois, Forenede Stater, 60035
    - NorthShore University HealthSystem-Highland Park Hospital
  - Highland Park, Illinois, Forenede Stater, 60035
    - Hematology Oncology Associates of Illinois-Highland Park
  - Hines, Illinois, Forenede Stater, 60141
    - Hines Veterans Administration Hospital
  - Kankakee, Illinois, Forenede Stater, 60901
    - Presence Saint Mary's Hospital
  - Kewanee, Illinois, Forenede Stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Libertyville, Illinois, Forenede Stater, 60048
    - NorthShore Hematology Oncology-Libertyville
  - Macomb, Illinois, Forenede Stater, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, Forenede Stater, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Maywood, Illinois, Forenede Stater, 60153
    - Loyola University Medical Center
  - Moline, Illinois, Forenede Stater, 61265
    - Trinity Medical Center
  - Mount Vernon, Illinois, Forenede Stater, 62864
    - Good Samaritan Regional Health Center
  - Naperville, Illinois, Forenede Stater, 60540
    - Hematology Oncology Consultants Limited
  - New Lenox, Illinois, Forenede Stater, 60451
    - UC Comprehensive Cancer Center at Silver Cross
  - Niles, Illinois, Forenede Stater, 60714
    - Illinois Cancer Specialists-Niles
  - Normal, Illinois, Forenede Stater, 61761
    - Community Cancer Center Foundation
  - Ottawa, Illinois, Forenede Stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Ottawa, Illinois, Forenede Stater, 61350
    - Radiation Oncology of Northern Illinois
  - Pekin, Illinois, Forenede Stater, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Forenede Stater, 61554
    - OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
  - Peoria, Illinois, Forenede Stater, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Forenede Stater, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Forenede Stater, 61615
    - OSF Saint Francis Radiation Oncology at Peoria Cancer Center
  - Peoria, Illinois, Forenede Stater, 61603
    - Methodist Medical Center of Illinois
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forenede Stater, 61354
    - Valley Radiation Oncology
  - Princeton, Illinois, Forenede Stater, 61356
    - Illinois CancerCare-Princeton
  - Skokie, Illinois, Forenede Stater, 60076
    - Hematology Oncology Associates of Illinois - Skokie
  - Skokie, Illinois, Forenede Stater, 60076
    - North Shore Medical Center
  - Springfield, Illinois, Forenede Stater, 62781
    - Memorial Medical Center
  - Springfield, Illinois, Forenede Stater, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Forenede Stater, 62702
    - Springfield Clinic
  - Springfield, Illinois, Forenede Stater, 62702
    - Central Illinois Hematology Oncology Center
  - Swansea, Illinois, Forenede Stater, 62226
    - Cancer Care Specialists of Illinois-Swansea
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Forenede Stater, 61801
    - The Carle Foundation Hospital
  - Warrenville, Illinois, Forenede Stater, 60555
    - Northwestern Medicine Cancer Center Warrenville
  - Yorkville, Illinois, Forenede Stater, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Crown Point, Indiana, Forenede Stater, 46307
    - Michiana Hematology Oncology PC-Crown Point
  - Elkhart, Indiana, Forenede Stater, 46514
    - Michiana Hematology Oncology PC-Elkhart
  - Fishers, Indiana, Forenede Stater, 46037
    - IU Health Central Indiana Cancer Centers-Fishers
  - Indianapolis, Indiana, Forenede Stater, 46237
    - Franciscan Health Indianapolis
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Sidney and Lois Eskenazi Hospital
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Richard L. Roudebush Veterans Affairs Medical Center
  - Indianapolis, Indiana, Forenede Stater, 46219
    - IU Health Central Indiana Cancer Centers-East
  - Indianapolis, Indiana, Forenede Stater, 46290
    - Springmill Medical Center
  - Lafayette, Indiana, Forenede Stater, 47904
    - IU Health Arnett Cancer Care
  - Michigan City, Indiana, Forenede Stater, 46360
    - Franciscan Saint Anthony Health-Michigan City
  - Michigan City, Indiana, Forenede Stater, 46360
    - Woodland Cancer Care Center
  - Mishawaka, Indiana, Forenede Stater, 46545
    - Memorial Regional Cancer Center Day Road
  - Mishawaka, Indiana, Forenede Stater, 46545
    - Michiana Hematology Oncology PC-Mishawaka
  - Mooresville, Indiana, Forenede Stater, 46158
    - Franciscan Health Mooresville
  - Munster, Indiana, Forenede Stater, 46321
    - The Community Hospital
  - Plymouth, Indiana, Forenede Stater, 46563
    - Michiana Hematology Oncology PC-Plymouth
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Health
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forenede Stater, 46601
    - Michiana Hematology Oncology PC-South Bend
  - South Bend, Indiana, Forenede Stater, 46628
    - Northern Indiana Cancer Research Consortium
  - Terre Haute, Indiana, Forenede Stater, 47804
    - Union Hospital
  - Westville, Indiana, Forenede Stater, 46391
    - Michiana Hematology Oncology PC-Westville
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - Mary Greeley Medical Center
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic PC-William R Bliss Cancer Center
  - Bettendorf, Iowa, Forenede Stater, 52722
    - University of Iowa Healthcare Cancer Services Quad Cities
  - Boone, Iowa, Forenede Stater, 50036
    - McFarland Clinic PC-Boone
  - Clive, Iowa, Forenede Stater, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, Forenede Stater, 50325
    - Medical Oncology and Hematology Associates-West Des Moines
  - Council Bluffs, Iowa, Forenede Stater, 51503
    - Alegent Health Mercy Hospital
  - Creston, Iowa, Forenede Stater, 50801
    - Greater Regional Medical Center
  - Davenport, Iowa, Forenede Stater, 52803
    - Genesis Medical Center - East Campus
  - Des Moines, Iowa, Forenede Stater, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50309
    - Medical Oncology and Hematology Associates-Des Moines
  - Des Moines, Iowa, Forenede Stater, 50316
    - Iowa Lutheran Hospital
  - Des Moines, Iowa, Forenede Stater, 50309
    - Iowa-Wide Oncology Research Coalition NCORP
  - Des Moines, Iowa, Forenede Stater, 50314
    - Medical Oncology and Hematology Associates-Laurel
  - Fairfield, Iowa, Forenede Stater, 52556
    - JCHC McCreery Cancer Center
  - Fort Dodge, Iowa, Forenede Stater, 50501
    - McFarland Clinic PC-Trinity Cancer Center
  - Iowa City, Iowa, Forenede Stater, 52242
    - University of Iowa/Holden Comprehensive Cancer Center
  - Jefferson, Iowa, Forenede Stater, 50129
    - McFarland Clinic PC-Jefferson
  - Marshalltown, Iowa, Forenede Stater, 50158
    - McFarland Clinic PC-Marshalltown
  - Ottumwa, Iowa, Forenede Stater, 52501
    - Ottumwa Regional Health Center
  - Sioux City, Iowa, Forenede Stater, 51101
    - Siouxland Regional Cancer Center
  - Waterloo, Iowa, Forenede Stater, 50702
    - Covenant Medical Center
  - West Des Moines, Iowa, Forenede Stater, 50266-7700
    - Methodist West Hospital
  - West Des Moines, Iowa, Forenede Stater, 50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Chanute, Kansas, Forenede Stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forenede Stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas - El Dorado
  - Emporia, Kansas, Forenede Stater, 66801
    - Newman Regional Health
  - Fort Scott, Kansas, Forenede Stater, 66701
    - Cancer Center of Kansas - Fort Scott
  - Garden City, Kansas, Forenede Stater, 67846
    - Saint Catherine Hospital
  - Great Bend, Kansas, Forenede Stater, 67530
    - Saint Rose Ambulatory and Surgery Center
  - Hays, Kansas, Forenede Stater, 67601
    - Hays Medical Center
  - Independence, Kansas, Forenede Stater, 67301
    - Cancer Center of Kansas-Independence
  - Kansas City, Kansas, Forenede Stater, 66160
    - University of Kansas Cancer Center
  - Kansas City, Kansas, Forenede Stater, 66112
    - University of Kansas Cancer Center-West
  - Kingman, Kansas, Forenede Stater, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Forenede Stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forenede Stater, 67905
    - Cancer Center of Kansas-Liberal
  - Newton, Kansas, Forenede Stater, 67114
    - Cancer Center of Kansas - Newton
  - Olathe, Kansas, Forenede Stater, 66061
    - Olathe Medical Center
  - Overland Park, Kansas, Forenede Stater, 66210
    - University of Kansas Cancer Center-Overland Park
  - Overland Park, Kansas, Forenede Stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forenede Stater, 66213
    - Saint Luke's South Hospital
  - Parsons, Kansas, Forenede Stater, 67357
    - Cancer Center of Kansas - Parsons
  - Pittsburg, Kansas, Forenede Stater, 66762
    - Via Christi Hospital-Pittsburg
  - Prairie Village, Kansas, Forenede Stater, 66208
    - Kansas City NCI Community Oncology Research Program
  - Pratt, Kansas, Forenede Stater, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Forenede Stater, 67401
    - Salina Regional Health Center
  - Salina, Kansas, Forenede Stater, 67401
    - Cancer Center of Kansas - Salina
  - Topeka, Kansas, Forenede Stater, 66606
    - Cotton O'Neil Cancer Center / Stormont Vail Health
  - Topeka, Kansas, Forenede Stater, 66606
    - Saint Francis Hospital and Medical Center - Topeka
  - Wellington, Kansas, Forenede Stater, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Forenede Stater, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas - Wichita
  - Wichita, Kansas, Forenede Stater, 67208
    - Associates In Womens Health
  - Wichita, Kansas, Forenede Stater, 67214
    - Wichita NCI Community Oncology Research Program
  - Wichita, Kansas, Forenede Stater, 67214
    - Via Christi Regional Medical Center
  - Winfield, Kansas, Forenede Stater, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Ashland, Kentucky, Forenede Stater, 41101
    - King's Daughter's Medical Center
  - Bardstown, Kentucky, Forenede Stater, 40004
    - Flaget Memorial Hospital
  - Corbin, Kentucky, Forenede Stater, 40701
    - Baptist Health Corbin
  - Corbin, Kentucky, Forenede Stater, 40701
    - Commonwealth Cancer Center-Corbin
  - Crestview Hills, Kentucky, Forenede Stater, 41017
    - Oncology Hematology Care Inc-Crestview
  - Elizabethtown, Kentucky, Forenede Stater, 42701
    - Hardin Memorial Hospital
  - Lexington, Kentucky, Forenede Stater, 40536
    - University of Kentucky/Markey Cancer Center
  - Lexington, Kentucky, Forenede Stater, 40504
    - Saint Joseph Radiation Oncology Resource Center
  - Lexington, Kentucky, Forenede Stater, 40509
    - Saint Joseph Hospital East
  - Lexington, Kentucky, Forenede Stater, 40503
    - Baptist Health Lexington
  - Louisville, Kentucky, Forenede Stater, 40202
    - Norton Hospital Pavilion and Medical Campus
  - Louisville, Kentucky, Forenede Stater, 40241
    - Norton Brownsboro Hospital and Medical Campus
  - Louisville, Kentucky, Forenede Stater, 40202
    - Jewish Hospital
  - Louisville, Kentucky, Forenede Stater, 40207
    - Norton Suburban Hospital and Medical Campus
  - Louisville, Kentucky, Forenede Stater, 40207
    - Baptist Health Louisville
  - Louisville, Kentucky, Forenede Stater, 40215
    - Saints Mary and Elizabeth Hospital
  - Louisville, Kentucky, Forenede Stater, 40217
    - Norton Audubon Hospital and Medical Campus
  - Louisville, Kentucky, Forenede Stater, 40245
    - Jewish Hospital Medical Center Northeast
  - Madisonville, Kentucky, Forenede Stater, 42431
    - Baptist Health Madisonville/Merle Mahr Cancer Center
  - Paducah, Kentucky, Forenede Stater, 42003
    - Baptist Health Paducah
  - Shepherdsville, Kentucky, Forenede Stater, 40165
    - Jewish Hospital Medical Center South
- Louisiana
  - Baton Rouge, Louisiana, Forenede Stater, 70805
    - LSU Health Baton Rouge-North Clinic
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Louisiana Hematology Oncology Associates LLC
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Ochsner Health Center-Summa
  - Baton Rouge, Louisiana, Forenede Stater, 70806
    - Baton Rouge General Medical Center
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Hematology/Oncology Clinic LLP
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Medical Oncology LLC
  - Covington, Louisiana, Forenede Stater, 70433
    - Mary Bird Cancer Center/Saint Tammany Parish
  - Houma, Louisiana, Forenede Stater, 70360
    - Mary Bird Perkins Cancer Center/Terrebonne General Medical Center
  - Kenner, Louisiana, Forenede Stater, 70065
    - Ochsner Medical Center Kenner
  - Marrero, Louisiana, Forenede Stater, 70072
    - West Jefferson Medical Center
  - Metairie, Louisiana, Forenede Stater, 70006
    - East Jefferson General Hospital
  - Metairie, Louisiana, Forenede Stater, 70006
    - Robert Veith MD LLC
  - Monroe, Louisiana, Forenede Stater, 71202
    - University Health-Conway
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Medical Center Jefferson
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Tulane University Health Sciences Center
  - New Orleans, Louisiana, Forenede Stater, 70112
    - University Medical Center New Orleans
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Louisiana State University Health Science Center
  - New Orleans, Louisiana, Forenede Stater, 70115
    - LSU Healthcare Network/Saint Charles
  - Shreveport, Louisiana, Forenede Stater, 71103
    - Louisiana State University Health Sciences Center Shreveport
- Maine
  - Augusta, Maine, Forenede Stater, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Forenede Stater, 04401
    - Eastern Maine Medical Center
  - Brewer, Maine, Forenede Stater, 04412
    - Lafayette Family Cancer Center-EMMC
  - Portland, Maine, Forenede Stater, 04101
    - Mercy Hospital
  - Rockport, Maine, Forenede Stater, 04856
    - Penobscot Bay Medical Center
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21237
    - MedStar Franklin Square Medical Center/Weinberg Cancer Institute
  - Baltimore, Maryland, Forenede Stater, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Forenede Stater, 21204
    - Greater Baltimore Medical Center
  - Baltimore, Maryland, Forenede Stater, 21201
    - University of Maryland/Greenebaum Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21218
    - MedStar Union Memorial Hospital
  - Baltimore, Maryland, Forenede Stater, 21229
    - Saint Agnes Hospital
  - Bel Air, Maryland, Forenede Stater, 21014
    - Upper Chesapeake Medical Center
  - Bethesda, Maryland, Forenede Stater, 20889-5600
    - Walter Reed National Military Medical Center
  - Cumberland, Maryland, Forenede Stater, 21502
    - Western Maryland Regional Medical Center
  - Frederick, Maryland, Forenede Stater, 21701
    - Frederick Memorial Hospital
  - Olney, Maryland, Forenede Stater, 20832
    - Montgomery General Hospital-Olney
  - Randallstown, Maryland, Forenede Stater, 21133
    - Northwest Hospital Center
  - Salisbury, Maryland, Forenede Stater, 21801
    - Peninsula Regional Medical Center
- Massachusetts
  - Beverly, Massachusetts, Forenede Stater, 01915
    - Beverly Hospital
  - Boston, Massachusetts, Forenede Stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forenede Stater, 02118
    - Boston Medical Center
  - Boston, Massachusetts, Forenede Stater, 02114
    - Massachusetts General Hospital Cancer Center
  - Burlington, Massachusetts, Forenede Stater, 01805
    - Lahey Hospital and Medical Center
  - Fitchburg, Massachusetts, Forenede Stater, 01420
    - Simonds-Sinon Regional Cancer Center
  - Gloucester, Massachusetts, Forenede Stater, 01930
    - Addison Gilbert Hospital
  - Lowell, Massachusetts, Forenede Stater, 01854
    - Lowell General Hospital
  - Springfield, Massachusetts, Forenede Stater, 01199
    - Baystate Medical Center
  - Winchester, Massachusetts, Forenede Stater, 01890
    - Winchester Hospital
  - Worcester, Massachusetts, Forenede Stater, 01655
    - University of Massachusetts Medical School
- Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48106-0995
    - Saint Joseph Mercy Hospital
  - Ann Arbor, Michigan, Forenede Stater, 48109
    - University of Michigan Comprehensive Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48105
    - Veteran's Administration Medical Center - Ann Arbor
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Bronson Battle Creek
  - Dearborn, Michigan, Forenede Stater, 48124
    - Beaumont Hospital-Dearborn
  - Detroit, Michigan, Forenede Stater, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Forenede Stater, 48236
    - Saint John Hospital and Medical Center
  - Detroit, Michigan, Forenede Stater, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Escanaba, Michigan, Forenede Stater, 49829
    - Green Bay Oncology - Escanaba
  - Farmington, Michigan, Forenede Stater, 48334
    - Botsford General Hospital
  - Farmington Hills, Michigan, Forenede Stater, 48334
    - Weisberg Cancer Treatment Center
  - Flint, Michigan, Forenede Stater, 48502
    - Hurley Medical Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Spectrum Health at Butterworth Campus
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Mercy Health Saint Mary's
  - Grosse Pointe, Michigan, Forenede Stater, 48230
    - William Beaumont Hospital-Grosse Point
  - Jackson, Michigan, Forenede Stater, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forenede Stater, 49001
    - Borgess Medical Center
  - Lansing, Michigan, Forenede Stater, 48912
    - Sparrow Hospital
  - Livonia, Michigan, Forenede Stater, 48154
    - Saint Mary Mercy Hospital
  - Midland, Michigan, Forenede Stater, 48670
    - Mid-Michigan Medical Center - Midland
  - Monroe, Michigan, Forenede Stater, 48162
    - Monroe Cancer Center
  - Muskegon, Michigan, Forenede Stater, 49444
    - Mercy Health Mercy Campus
  - Niles, Michigan, Forenede Stater, 49120
    - Lakeland Community Hospital
  - Novi, Michigan, Forenede Stater, 48374-1236
    - Assarian Cancer Center
  - Pontiac, Michigan, Forenede Stater, 48341
    - Saint Joseph Mercy Oakland
  - Port Huron, Michigan, Forenede Stater, 48060
    - Lake Huron Medical Center
  - Reed City, Michigan, Forenede Stater, 49677
    - Spectrum Health Reed City Hospital
  - Roseville, Michigan, Forenede Stater, 48066
    - Michigan Cancer Specialists
  - Royal Oak, Michigan, Forenede Stater, 48073
    - William Beaumont Hospital-Royal Oak
  - Royal Oak, Michigan, Forenede Stater, 48067
    - Oakland Colon and Rectal Association
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Cancer Care Associates PC
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Comprehensive Medical Center PLLC
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Hematology Oncology Consultants PC
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Oakland Medical Group
  - Saginaw, Michigan, Forenede Stater, 48601
    - Saint Mary's of Michigan
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Marie Yeager Cancer Center
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Lakeland Hospital
  - Southfield, Michigan, Forenede Stater, 48075
    - Providence Hospital-Southfield Cancer Center
  - Sterling Heights, Michigan, Forenede Stater, 48312
    - Premier Hematology Oncology Care
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
  - Troy, Michigan, Forenede Stater, 48098
    - William Beaumont Hospital - Troy
  - Troy, Michigan, Forenede Stater, 48084
    - Michigan Institute of Urology-Town Center
  - Troy, Michigan, Forenede Stater, 48085
    - Claudia BR Herke MD PC
  - Troy, Michigan, Forenede Stater, 48098
    - Hematology Oncology Consultants PC-Troy
  - Warren, Michigan, Forenede Stater, 48093
    - Saint John Macomb-Oakland Hospital
  - Wyoming, Michigan, Forenede Stater, 49519
    - Metro Health Hospital
- Minnesota
  - Bemidji, Minnesota, Forenede Stater, 56601
    - Sanford Clinic North-Bemidgi
  - Brainerd, Minnesota, Forenede Stater, 56401
    - Essentia Health Saint Joseph's Medical Center
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy Hospital
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview-Southdale Hospital
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fridley, Minnesota, Forenede Stater, 55432
    - Unity Hospital
  - Hutchinson, Minnesota, Forenede Stater, 55350
    - Hutchinson Area Health Care
  - Maple Grove, Minnesota, Forenede Stater, 55369
    - Fairview Maple Grove Medical Center
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55454
    - Health Partners Inc
  - New Ulm, Minnesota, Forenede Stater, 56073
    - New Ulm Medical Center
  - Robbinsdale, Minnesota, Forenede Stater, 55422
    - North Memorial Medical Health Center
  - Rochester, Minnesota, Forenede Stater, 55905
    - Mayo Clinic
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Metro Minnesota Community Oncology Research Consortium
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Shakopee, Minnesota, Forenede Stater, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Forenede Stater, 55082
    - Lakeview Hospital
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forenede Stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Wyoming, Minnesota, Forenede Stater, 55092
    - Fairview Lakes Medical Center
- Mississippi
  - Columbus, Mississippi, Forenede Stater, 39705
    - Baptist Cancer Center-Golden Triangle
  - Grenada, Mississippi, Forenede Stater, 38901
    - Boston Baskin Cancer Center-Grenada
  - Jackson, Mississippi, Forenede Stater, 39216
    - University of Mississippi Medical Center
  - Oxford, Mississippi, Forenede Stater, 38655
    - Family Cancer Center-Oxford
  - Southaven, Mississippi, Forenede Stater, 38671
    - Family Cancer Center-Southhaven
  - Southhaven, Mississippi, Forenede Stater, 38671
    - Baptist Memorial Hospital-Desoto
  - Starkville, Mississippi, Forenede Stater, 39759
    - Baptist Cancer Institute-Starkville
- Missouri
  - Bolivar, Missouri, Forenede Stater, 65613
    - Central Care Cancer Center-Carrie J Babb Cancer Center
  - Bonne Terre, Missouri, Forenede Stater, 63628
    - Parkland Health Center-Bonne Terre
  - Branson, Missouri, Forenede Stater, 65616
    - CoxHealth Cancer Center
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Southeast Cancer Center
  - Chesterfield, Missouri, Forenede Stater, 63017
    - Saint Luke's Hospital
  - Columbia, Missouri, Forenede Stater, 65212
    - University of Missouri - Ellis Fischel
  - Creve Coeur, Missouri, Forenede Stater, 63141
    - Siteman Cancer Center at West County Hospital
  - Independence, Missouri, Forenede Stater, 64057
    - Centerpoint Medical Center LLC
  - Jefferson City, Missouri, Forenede Stater, 65109
    - Capital Region Medical Center-Goldschmidt Cancer Center
  - Joplin, Missouri, Forenede Stater, 64804
    - Freeman Health System
  - Joplin, Missouri, Forenede Stater, 64804
    - Mercy Hospital-Joplin
  - Kansas City, Missouri, Forenede Stater, 64128
    - Kansas City Veterans Affairs Medical Center
  - Kansas City, Missouri, Forenede Stater, 64131
    - The University of Kansas Cancer Center-South
  - Kansas City, Missouri, Forenede Stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forenede Stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forenede Stater, 64108
    - Truman Medical Center
  - Kansas City, Missouri, Forenede Stater, 64118
    - Heartland Hematology and Oncology Associates Incorporated
  - Kansas City, Missouri, Forenede Stater, 64154
    - The University of Kansas Cancer Center-North
  - Lee's Summit, Missouri, Forenede Stater, 64086
    - Saint Luke's East - Lee's Summit
  - Lee's Summit, Missouri, Forenede Stater, 64064
    - The University of Kansas Cancer Center-Lee's Summit
  - Liberty, Missouri, Forenede Stater, 64068
    - Liberty Radiation Oncology Center
  - Rolla, Missouri, Forenede Stater, 65401
    - Delbert Day Cancer Institute at PCRMC
  - Rolla, Missouri, Forenede Stater, 65401
    - Saint John's Clinic-Rolla-Cancer and Hematology
  - Saint Joseph, Missouri, Forenede Stater, 64506
    - Heartland Regional Medical Center
  - Saint Louis, Missouri, Forenede Stater, 63110
    - Washington University School of Medicine
  - Saint Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Medical Center
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Mercy Hospital Saint Louis
  - Saint Louis, Missouri, Forenede Stater, 63109
    - Saint Louis Cancer and Breast Institute-South City
  - Saint Peters, Missouri, Forenede Stater, 63376
    - Siteman Cancer Center at Saint Peters Hospital
  - Sainte Genevieve, Missouri, Forenede Stater, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Forenede Stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forenede Stater, 65804
    - Mercy Hospital Springfield
  - Sullivan, Missouri, Forenede Stater, 63080
    - Missouri Baptist Sullivan Hospital
  - Sunset Hills, Missouri, Forenede Stater, 63127
    - Missouri Baptist Outpatient Center-Sunset Hills
- Montana
  - Anaconda, Montana, Forenede Stater, 59711
    - Community Hospital of Anaconda
  - Billings, Montana, Forenede Stater, 59101
    - Billings Clinic Cancer Center
  - Billings, Montana, Forenede Stater, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Forenede Stater, 59102
    - Montana Cancer Consortium NCORP
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Deaconess Hospital
  - Butte, Montana, Forenede Stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Forenede Stater, 59405
    - Benefis Healthcare- Sletten Cancer Institute
  - Helena, Montana, Forenede Stater, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Regional Medical Center
  - Missoula, Montana, Forenede Stater, 59804
    - Community Medical Hospital
  - Missoula, Montana, Forenede Stater, 59802
    - Saint Patrick Hospital - Community Hospital
- Nebraska
  - Grand Island, Nebraska, Forenede Stater, 68803
    - CHI Health Saint Francis
  - Kearney, Nebraska, Forenede Stater, 68847
    - CHI Health Good Samaritan
  - Kearney, Nebraska, Forenede Stater, 68845
    - Heartland Hematology and Oncology
  - Lincoln, Nebraska, Forenede Stater, 68506
    - Nebraska Hematology and Oncology
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Nebraska Cancer Research Center
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Saint Elizabeth Regional Medical Center
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Southeast Nebraska Cancer Center
  - Norfolk, Nebraska, Forenede Stater, 68701
    - Faith Regional Medical Offices West
  - North Platte, Nebraska, Forenede Stater, 69103
    - Great Plains Regional Medical Center
  - Omaha, Nebraska, Forenede Stater, 68114
    - Nebraska Methodist Hospital
  - Omaha, Nebraska, Forenede Stater, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Forenede Stater, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Forenede Stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Forenede Stater, 68131
    - Creighton University Medical Center
  - Omaha, Nebraska, Forenede Stater, 68106
    - Missouri Valley Cancer Consortium
  - Omaha, Nebraska, Forenede Stater, 68130
    - Oncology Hematology West PC
  - Omaha, Nebraska, Forenede Stater, 68122
    - Hemotology and Oncology Consultants PC
  - Omaha, Nebraska, Forenede Stater, 68124
    - Oncology Hematology West
  - Papillion, Nebraska, Forenede Stater, 68046
    - Midlands Community Hospital
  - Scottsbluff, Nebraska, Forenede Stater, 69361
    - Regional West Medical Center
- Nevada
  - Carson City, Nevada, Forenede Stater, 89703
    - Carson Tahoe Regional Medical Center
  - Henderson, Nevada, Forenede Stater, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, Forenede Stater, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, Forenede Stater, 89074
    - 21st Century Oncology - Henderson
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Summerlin Hospital Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, Forenede Stater, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, Forenede Stater, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Forenede Stater, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Cancer and Blood Specialists-Shadow
  - Las Vegas, Nevada, Forenede Stater, 89109
    - HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
  - Las Vegas, Nevada, Forenede Stater, 89113
    - HealthCare Partners Medical Group Oncology/Hematology-San Martin
  - Las Vegas, Nevada, Forenede Stater, 89121
    - Cancer Therapy and Integrative Medicine
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Cancer and Blood Specialists-Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89128
    - HealthCare Partners Medical Group Oncology/Hematology-Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89149
    - HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
  - Las Vegas, Nevada, Forenede Stater, 89109
    - 21st Century Oncology
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Nevada Cancer Research Foundation CCOP
  - Las Vegas, Nevada, Forenede Stater, 89148
    - 21st Century Oncology - Fort Apache
  - Las Vegas, Nevada, Forenede Stater, 89148
    - Nevada Cancer Specialists-Fort Apache
  - Las Vegas, Nevada, Forenede Stater, 89182
    - 21st Century Oncology - Vegas Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Ann M Wierman MD LTD
  - Reno, Nevada, Forenede Stater, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89503
    - Saint Mary's Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89509
    - Radiation Oncology Associates
  - Reno, Nevada, Forenede Stater, 89503
    - Alpine Hematology-Oncology
  - Reno, Nevada, Forenede Stater, 89519
    - Reno Oncology Consultants
- New Hampshire
  - Concord, New Hampshire, Forenede Stater, 03301
    - New Hampshire Oncology Hematology PA-Concord
  - Hooksett, New Hampshire, Forenede Stater, 03106
    - New Hampshire Oncology Hematology PA-Hooksett
  - Laconia, New Hampshire, Forenede Stater, 03246
    - LRGHealthcare-Lakes Region General Hospital
  - Lebanon, New Hampshire, Forenede Stater, 03756
    - Dartmouth Hitchcock Medical Center
  - Manchester, New Hampshire, Forenede Stater, 03102
    - Norris Cotton Cancer Center-Manchester
- New Jersey
  - Brick, New Jersey, Forenede Stater, 08724
    - Ocean Medical Center
  - East Orange, New Jersey, Forenede Stater, 07018-1095
    - Veterans Adminstration New Jersey Health Care System
  - Manahawkin, New Jersey, Forenede Stater, 08050
    - Southern Ocean County Medical Center
  - Morristown, New Jersey, Forenede Stater, 07960
    - Morristown Medical Center
  - Mount Holly, New Jersey, Forenede Stater, 08060
    - Virtua Memorial
  - Neptune, New Jersey, Forenede Stater, 07753
    - Jersey Shore Medical Center
  - Newark, New Jersey, Forenede Stater, 07112
    - Newark Beth Israel Medical Center
  - Red Bank, New Jersey, Forenede Stater, 07701
    - Riverview Medical Center/Booker Cancer Center
  - Somerville, New Jersey, Forenede Stater, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Summit, New Jersey, Forenede Stater, 07902
    - Overlook Hospital
  - Voorhees, New Jersey, Forenede Stater, 08043
    - Virtua Voorhees
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - Lovelace Medical Center-Downtown
  - Albuquerque, New Mexico, Forenede Stater, 87109
    - New Mexico Oncology Hematology Consultants
  - Las Cruces, New Mexico, Forenede Stater, 88011
    - Memorial Medical Center - Las Cruces
- New York
  - Albany, New York, Forenede Stater, 12208
    - New York Oncology Hematology PC -Albany Medical Center
  - Bronx, New York, Forenede Stater, 10461
    - Montefiore Medical Center-Einstein Campus
  - Bronx, New York, Forenede Stater, 10461
    - Montefiore Medical Center-Weiler Hospital
  - Bronx, New York, Forenede Stater, 10467-2490
    - Montefiore Medical Center - Moses Campus
  - Brooklyn, New York, Forenede Stater, 11203
    - State University of New York Downstate Medical Center
  - Buffalo, New York, Forenede Stater, 14263
    - Roswell Park Cancer Institute
  - Cooperstown, New York, Forenede Stater, 13326
    - Mary Imogene Bassett Hospital
  - Elmira, New York, Forenede Stater, 14905
    - Arnot Ogden Medical Center/Falck Cancer Center
  - Glens Falls, New York, Forenede Stater, 12801
    - Glens Falls Hospital
  - Middletown, New York, Forenede Stater, 10940
    - Orange Regional Medical Center
  - New Hyde Park, New York, Forenede Stater, 11040
    - Northwell Health/Center for Advanced Medicine
  - New York, New York, Forenede Stater, 10003
    - Beth Israel Medical Center
  - New York, New York, Forenede Stater, 10032
    - Columbia University/Herbert Irving Cancer Center
  - Rochester, New York, Forenede Stater, 14642
    - University of Rochester
  - Rochester, New York, Forenede Stater, 14620
    - Highland Hospital
  - Syracuse, New York, Forenede Stater, 13210
    - State University of New York Upstate Medical University
  - Utica, New York, Forenede Stater, 13502
    - Faxton-Saint Luke's Healthcare
- North Carolina
  - Asheboro, North Carolina, Forenede Stater, 27203
    - Randolph Hospital
  - Asheville, North Carolina, Forenede Stater, 28801
    - Cancer Care of Western North Carolina
  - Asheville, North Carolina, Forenede Stater, 28801
    - Mission Hospital-Memorial Campus
  - Asheville, North Carolina, Forenede Stater, 28803
    - Asheville Hematology-Oncology Associates
  - Burlington, North Carolina, Forenede Stater, 27215
    - Cone Health Cancer Center at Alamance Regional
  - Charlotte, North Carolina, Forenede Stater, 28204
    - Novant Health Presbyterian Medical Center
  - Charlotte, North Carolina, Forenede Stater, 28207
    - Oncology Specialists of Charlotte
  - Charlotte, North Carolina, Forenede Stater, 28262
    - Southern Oncology Specialists-Charlotte
  - Clinton, North Carolina, Forenede Stater, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Clinton, North Carolina, Forenede Stater, 28328
    - Sampson Radiation Oncology
  - Durham, North Carolina, Forenede Stater, 27710
    - Duke University Medical Center
  - Fayetteville, North Carolina, Forenede Stater, 28304
    - Cape Fear Valley Health System
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Memorial Hospital
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Radiation Oncology
  - Greensboro, North Carolina, Forenede Stater, 27403
    - Cone Health Cancer Center
  - Hendersonville, North Carolina, Forenede Stater, 28791
    - Hendersonville Hematology and Oncology at Pardee
  - Hendersonville, North Carolina, Forenede Stater, 28791
    - Margaret R Pardee Memorial Hospital
  - Hendersonville, North Carolina, Forenede Stater, 28792
    - Park Ridge Hospital Breast Health Center
  - High Point, North Carolina, Forenede Stater, 27262
    - Hayworth Cancer Center
  - High Point, North Carolina, Forenede Stater, 27262
    - High Point Regional Hospital
  - Huntersville, North Carolina, Forenede Stater, 28078
    - Southern Oncology Specialists-Huntersville
  - Huntersville, North Carolina, Forenede Stater, 28078
    - Lake Norman Hematology Oncology Specialists-Huntersville
  - Jacksonville, North Carolina, Forenede Stater, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Jacksonville, North Carolina, Forenede Stater, 28546
    - Onslow Memorial Hospital
  - Kinston, North Carolina, Forenede Stater, 28501
    - Kinston Medical Specialists PA
  - Matthews, North Carolina, Forenede Stater, 28105
    - Novant Health Cancer Specialists-Matthews
  - Matthews, North Carolina, Forenede Stater, 28105
    - Matthews Radiation Oncology Center
  - Mebane, North Carolina, Forenede Stater, 27302
    - Cone Heath Cancer Center at Mebane
  - Mooresville, North Carolina, Forenede Stater, 28117
    - Lake Norman Hematology Oncology Specialists-Mooresville
  - Pinehurst, North Carolina, Forenede Stater, 28374
    - FirstHealth of the Carolinas-Moore Regional Hosiptal
  - Raleigh, North Carolina, Forenede Stater, 27609
    - Duke Raleigh Hospital
  - Reidsville, North Carolina, Forenede Stater, 27320
    - Annie Penn Memorial Hospital
  - Wilson, North Carolina, Forenede Stater, 27893
    - Southeastern Medical Oncology Center-Wilson
  - Winston-Salem, North Carolina, Forenede Stater, 27157
    - Wake Forest University Health Sciences
  - Winston-Salem, North Carolina, Forenede Stater, 27104
    - Southeast Clinical Oncology Research (SCOR) Consortium NCORP
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Sanford Bismarck Medical Center
  - Fargo, North Dakota, Forenede Stater, 58103
    - Essentia Health Cancer Center-South University Clinic
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Broadway Medical Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Clinic North-Fargo
  - Fargo, North Dakota, Forenede Stater, 58122
    - Roger Maris Cancer Center
  - Minot, North Dakota, Forenede Stater, 58701
    - Trinity Cancer Care Center
- Ohio
  - Beachwood, Ohio, Forenede Stater, 44122
    - UHHS-Chagrin Highlands Medical Center
  - Beachwood, Ohio, Forenede Stater, 44122
    - Cleveland Clinic Cancer Center Beachwood
  - Belpre, Ohio, Forenede Stater, 45714
    - Strecker Cancer Center-Belpre
  - Canton, Ohio, Forenede Stater, 44710
    - Aultman Health Foundation
  - Canton, Ohio, Forenede Stater, 44708
    - Mercy Medical Center
  - Centerville, Ohio, Forenede Stater, 45459
    - Miami Valley Hospital South
  - Centerville, Ohio, Forenede Stater, 45459
    - Dayton Physicians LLC-Miami Valley South
  - Chardon, Ohio, Forenede Stater, 44024
    - Geauga Hospital
  - Chillicothe, Ohio, Forenede Stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, Forenede Stater, 45242
    - Bethesda North Hospital
  - Cincinnati, Ohio, Forenede Stater, 45242
    - Oncology Hematology Care Inc-Blue Ash
  - Cincinnati, Ohio, Forenede Stater, 45202
    - Oncology Hematology Care Inc-Eden Park
  - Cincinnati, Ohio, Forenede Stater, 45211
    - Oncology Hematology Care Inc-Mercy West
  - Cincinnati, Ohio, Forenede Stater, 45236
    - Oncology Hematology Care Inc-Kenwood
  - Cincinnati, Ohio, Forenede Stater, 45219
    - University of Cincinnati/Barrett Cancer Center
  - Cincinnati, Ohio, Forenede Stater, 45230
    - Oncology Hematology Care Inc - Anderson
  - Cincinnati, Ohio, Forenede Stater, 45247
    - TriHealth Cancer Institute-Westside
  - Cincinnati, Ohio, Forenede Stater, 45255
    - TriHealth Cancer Institute-Anderson
  - Cleveland, Ohio, Forenede Stater, 44106
    - Case Western Reserve University
  - Cleveland, Ohio, Forenede Stater, 44109
    - MetroHealth Medical Center
  - Cleveland, Ohio, Forenede Stater, 44195
    - Cleveland Clinic Foundation
  - Cleveland, Ohio, Forenede Stater, 44111
    - Cleveland Clinic Cancer Center/Fairview Hospital
  - Columbus, Ohio, Forenede Stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forenede Stater, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Forenede Stater, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Forenede Stater, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Forenede Stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forenede Stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel Health Center West
  - Columbus, Ohio, Forenede Stater, 43215
    - Columbus NCI Community Oncology Research Program
  - Dayton, Ohio, Forenede Stater, 45406
    - Good Samaritan Hospital - Dayton
  - Dayton, Ohio, Forenede Stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Dayton Physicians LLC-Samaritan North
  - Dayton, Ohio, Forenede Stater, 45415
    - Samaritan North Health Center
  - Dayton, Ohio, Forenede Stater, 45420
    - Dayton NCI Community Oncology Research Program
  - Delaware, Ohio, Forenede Stater, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Forenede Stater, 43015
    - Delaware Radiation Oncology
  - Delaware, Ohio, Forenede Stater, 43015
    - Grady Memorial Hospital
  - Elyria, Ohio, Forenede Stater, 44035
    - Mercy Cancer Center-Elyria
  - Fairfield, Ohio, Forenede Stater, 45014
    - Oncology Hematology Care Inc-Healthplex
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Hospital
  - Findlay, Ohio, Forenede Stater, 45840
    - Armes Family Cancer Center
  - Findlay, Ohio, Forenede Stater, 45840
    - Orion Cancer Care
  - Franklin, Ohio, Forenede Stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Franklin, Ohio, Forenede Stater, 45005
    - Dayton Physicians LLC-Atrium
  - Greenville, Ohio, Forenede Stater, 45331
    - Wayne Hospital
  - Greenville, Ohio, Forenede Stater, 45331
    - Dayton Physicians LLC-Wayne
  - Independence, Ohio, Forenede Stater, 44131
    - Cleveland Clinic Cancer Center Independence
  - Kettering, Ohio, Forenede Stater, 45429
    - Kettering Medical Center
  - Kettering, Ohio, Forenede Stater, 45409
    - Greater Dayton Cancer Center
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Lancaster, Ohio, Forenede Stater, 43130
    - Lancaster Radiation Oncology
  - Mansfield, Ohio, Forenede Stater, 44906
    - Cleveland Clinic Cancer Center Mansfield
  - Marietta, Ohio, Forenede Stater, 45750
    - Marietta Memorial Hospital
  - Marion, Ohio, Forenede Stater, 43302
    - OneHealth Marion General Hospital
  - Mayfield Heights, Ohio, Forenede Stater, 44124
    - Hillcrest Hospital Cancer Center
  - Mayfield Heights, Ohio, Forenede Stater, 44124
    - Ireland Cancer Center Landerbrook Health Center
  - Mentor, Ohio, Forenede Stater, 44060
    - Lake University Ireland Cancer Center
  - Middleburg Heights, Ohio, Forenede Stater, 44130
    - Southwest General Health Center Ireland Cancer Center
  - Middletown, Ohio, Forenede Stater, 45042
    - Dayton Physicians LLC-Signal Point
  - Mount Vernon, Ohio, Forenede Stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Newark Radiation Oncology
  - Portsmouth, Ohio, Forenede Stater, 45662
    - Southern Ohio Medical Center
  - Sandusky, Ohio, Forenede Stater, 44870
    - North Coast Cancer Care
  - Sandusky, Ohio, Forenede Stater, 44870
    - Ireland Cancer Center at Firelands Regional Medical Center
  - Sidney, Ohio, Forenede Stater, 45365
    - Dayton Physicians LLC-Wilson
  - Springfield, Ohio, Forenede Stater, 45505
    - Springfield Regional Medical Center
  - Springfield, Ohio, Forenede Stater, 45504
    - Springfield Regional Cancer Center
  - Strongsville, Ohio, Forenede Stater, 44136
    - Cleveland Clinic Cancer Center Strongsville
  - Sylvania, Ohio, Forenede Stater, 43560
    - Flower Hospital
  - Toledo, Ohio, Forenede Stater, 43614
    - University of Toledo
  - Troy, Ohio, Forenede Stater, 45373
    - Upper Valley Medical Center
  - Troy, Ohio, Forenede Stater, 45373
    - Dayton Physicians LLC-Upper Valley
  - Wadsworth, Ohio, Forenede Stater, 44281
    - University Hospitals Sharon Health Center
  - Warrensville Heights, Ohio, Forenede Stater, 44122
    - South Pointe Hospital
  - West Chester, Ohio, Forenede Stater, 45069
    - University Pointe
  - Westerville, Ohio, Forenede Stater, 43081
    - Saint Ann's Hospital
  - Westlake, Ohio, Forenede Stater, 44145
    - UHHS-Westlake Medical Center
  - Westlake, Ohio, Forenede Stater, 44145
    - UH-Seidman Cancer Center at Saint John Medical Center
  - Wooster, Ohio, Forenede Stater, 44691
    - Cleveland Clinic Wooster Family Health and Surgery Center
  - Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433-5529
    - Wright-Patterson Medical Center
  - Zanesville, Ohio, Forenede Stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Lawton, Oklahoma, Forenede Stater, 73505
    - Cancer Centers of Southwest Oklahoma Research
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - University of Oklahoma Health Sciences Center
  - Tulsa, Oklahoma, Forenede Stater, 74146
    - Oklahoma Cancer Specialists and Research Institute-Tulsa
- Oregon
  - Bend, Oregon, Forenede Stater, 97701
    - Saint Charles Health System
  - Clackamas, Oregon, Forenede Stater, 97015
    - Clackamas Radiation Oncology Center
  - Clackamas, Oregon, Forenede Stater, 97015
    - Providence Oncology and Hematology Care Southeast
  - Coos Bay, Oregon, Forenede Stater, 97420
    - Bay Area Hospital
  - Gresham, Oregon, Forenede Stater, 97030
    - Legacy Mount Hood Medical Center
  - Newberg, Oregon, Forenede Stater, 97132
    - Providence Newberg Medical Center
  - Oregon City, Oregon, Forenede Stater, 97045
    - Providence Willamette Falls Medical Center
  - Portland, Oregon, Forenede Stater, 97239
    - Oregon Health and Science University
  - Portland, Oregon, Forenede Stater, 97210
    - Legacy Good Samaritan Hospital and Medical Center
  - Portland, Oregon, Forenede Stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - Providence Saint Vincent Medical Center
  - Portland, Oregon, Forenede Stater, 97227
    - Kaiser Permanente Northwest
  - Salem, Oregon, Forenede Stater, 97301
    - Salem Hospital
  - Tualatin, Oregon, Forenede Stater, 97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Beaver, Pennsylvania, Forenede Stater, 15009
    - UPMC-Heritage Valley Health System Beaver
  - Bryn Mawr, Pennsylvania, Forenede Stater, 19010
    - Bryn Mawr Hospital
  - Chadds Ford, Pennsylvania, Forenede Stater, 19317
    - Christiana Care Health System-Concord Health Center
  - Danville, Pennsylvania, Forenede Stater, 17822
    - Geisinger Medical Center
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Cancer Center
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Community Hospital
  - Gettysburg, Pennsylvania, Forenede Stater, 17325
    - Adams Cancer Center
  - Greensburg, Pennsylvania, Forenede Stater, 15601
    - UPMC Cancer Centers - Arnold Palmer Pavilion
  - Hanover, Pennsylvania, Forenede Stater, 17331
    - Cherry Tree Cancer Center
  - Harrisburg, Pennsylvania, Forenede Stater, 17109
    - PinnacleHealth Cancer Center-Community Campus
  - Hazleton, Pennsylvania, Forenede Stater, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hershey, Pennsylvania, Forenede Stater, 17033-0850
    - Penn State Milton S Hershey Medical Center
  - Jefferson Hills, Pennsylvania, Forenede Stater, 15025
    - Jefferson Hospital
  - Johnstown, Pennsylvania, Forenede Stater, 15901
    - UPMC-Johnstown/John P. Murtha Regional Cancer Center
  - Kittanning, Pennsylvania, Forenede Stater, 16201
    - Armstrong Center for Medicine and Health
  - Lewisburg, Pennsylvania, Forenede Stater, 17837
    - Geisinger Medical Oncology-Lewisburg
  - Lewistown, Pennsylvania, Forenede Stater, 17044
    - Lewistown Hospital
  - McKeesport, Pennsylvania, Forenede Stater, 15132
    - UPMC Cancer Center at UPMC McKeesport
  - Media, Pennsylvania, Forenede Stater, 19063
    - Riddle Memorial Hospital
  - Monroeville, Pennsylvania, Forenede Stater, 15146
    - Forbes Hospital
  - Moon, Pennsylvania, Forenede Stater, 15108
    - UPMC-Coraopolis/Heritage Valley Radiation Oncology
  - Natrona Heights, Pennsylvania, Forenede Stater, 15065
    - Allegheny Valley Hospital
  - Paoli, Pennsylvania, Forenede Stater, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19104
    - University of Pennsylvania/Abramson Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19140
    - Temple University Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15212
    - Allegheny General Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15224
    - West Penn Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15213
    - UPMC-Magee Womens Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - University of Pittsburgh Cancer Institute (UPCI)
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - UPMC-Shadyside Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15213
    - UPMC-Presbyterian Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15215
    - UPMC-Saint Margaret
  - Pittsburgh, Pennsylvania, Forenede Stater, 15236
    - UPMC Jefferson Regional Radiation Oncology
  - Pittsburgh, Pennsylvania, Forenede Stater, 15237
    - UPMC-Passavant Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15243
    - UPMC-Saint Clair Hospital Cancer Center
  - Pottstown, Pennsylvania, Forenede Stater, 19464
    - Pottstown Memorial Medical Center
  - Pottsville, Pennsylvania, Forenede Stater, 17901
    - Geisinger Medical Oncology-Pottsville
  - Reading, Pennsylvania, Forenede Stater, 19605
    - Penn State Health Saint Joseph Medical Center
  - Sayre, Pennsylvania, Forenede Stater, 18840
    - Guthrie Medical Group PC-Robert Packer Hospital
  - Selinsgrove, Pennsylvania, Forenede Stater, 17870
    - Geisinger Medical Oncology-Selinsgrove
  - Seneca, Pennsylvania, Forenede Stater, 16346
    - UPMC Cancer Center at UPMC Northwest
  - State College, Pennsylvania, Forenede Stater, 16801
    - Geisinger Medical Group
  - Uniontown, Pennsylvania, Forenede Stater, 15401
    - UPMC Uniontown Hospital Radiation Oncology
  - Washington, Pennsylvania, Forenede Stater, 15301
    - UPMC Washington Hospital Radiation Oncology
  - West Chester, Pennsylvania, Forenede Stater, 19380
    - Chester County Hospital
  - West Reading, Pennsylvania, Forenede Stater, 19611
    - Reading Hospital
  - Wexford, Pennsylvania, Forenede Stater, 15090
    - Wexford Health and Wellness Pavilion
  - Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Williamsport, Pennsylvania, Forenede Stater, 17701
    - UPMC Susquehanna
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Lankenau Medical Center
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Cancer Center
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Hospital
- South Carolina
  - Anderson, South Carolina, Forenede Stater, 29621
    - AnMed Health Cancer Center
  - Charleston, South Carolina, Forenede Stater, 29401
    - Roper Hospital
  - Charleston, South Carolina, Forenede Stater, 29403
    - Charleston Hematology Oncology Associates-Roper
  - Charleston, South Carolina, Forenede Stater, 29406
    - Lowcountry Hematology Oncology PA-North Charleston
  - Charleston, South Carolina, Forenede Stater, 29414
    - Bon Secours Saint Francis Hospital
  - Charleston, South Carolina, Forenede Stater, 29414
    - Charleston Hematology Oncology Associates PA-St. Francis
  - Charleston, South Carolina, Forenede Stater, 29414
    - Lowcountry Hematology Oncology PA-West Ashley
  - Easley, South Carolina, Forenede Stater, 29640
    - Greenville Health System Cancer Institute-Easley
  - Gaffney, South Carolina, Forenede Stater, 29341
    - Gibbs Cancer Center-Gaffney
  - Georgetown, South Carolina, Forenede Stater, 29440
    - Georgetown Hospital System
  - Greenville, South Carolina, Forenede Stater, 29607
    - Saint Francis Cancer Center
  - Greenville, South Carolina, Forenede Stater, 29601
    - Saint Francis Hospital
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Health System Cancer Institute-Andrews
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Health System Cancer Institute-Faris
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Memorial Hospital
  - Greenville, South Carolina, Forenede Stater, 29615
    - Greenville Health System Cancer Institute-Eastside
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Health System Cancer Institute-Butternut
  - Greer, South Carolina, Forenede Stater, 29651
    - Gibbs Cancer Center-Pelham
  - Lancaster, South Carolina, Forenede Stater, 29720
    - Carolina Blood and Cancer Care Associates PA-Lancaster
  - Mount Pleasant, South Carolina, Forenede Stater, 29464
    - Lowcountry Hematology Oncology PA-Mount Pleasant
  - Seneca, South Carolina, Forenede Stater, 29672
    - Greenville Health System Cancer Institute-Seneca
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Spartanburg Medical Center
  - Spartanburg, South Carolina, Forenede Stater, 29307
    - Greenville Health System Cancer Institute-Spartanburg
  - Union, South Carolina, Forenede Stater, 29379
    - MGC Hematology Oncology-Union
  - West Columbia, South Carolina, Forenede Stater, 29169
    - Lexington Medical Center
- South Dakota
  - Aberdeen, South Dakota, Forenede Stater, 57401
    - Avera Cancer Institute-Aberdeen
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sanford Cancer Center-Oncology Clinic
- Tennessee
  - Bartlett, Tennessee, Forenede Stater, 38133
    - Boston Baskin Cancer Center-Bartlett
  - Chattanooga, Tennessee, Forenede Stater, 37404
    - Memorial Hospital
  - Cookeville, Tennessee, Forenede Stater, 38501
    - Cookeville Regional Medical Center
  - Franklin, Tennessee, Forenede Stater, 37067
    - Vanderbilt-Ingram Cancer Center Cool Springs
  - Hixson, Tennessee, Forenede Stater, 37343
    - Pulmonary Medicine Center of Chattanooga-Hixson
  - Knoxville, Tennessee, Forenede Stater, 37916
    - Thompson Cancer Survival Center
  - Memphis, Tennessee, Forenede Stater, 38120
    - Baptist Memorial Hospital and Cancer Center-Memphis
  - Memphis, Tennessee, Forenede Stater, 38120
    - Baptist Memorial Hospital for Women
  - Memphis, Tennessee, Forenede Stater, 38120
    - Family Cancer Center-Memphis
  - Nashville, Tennessee, Forenede Stater, 37232
    - Vanderbilt University/Ingram Cancer Center
  - Nashville, Tennessee, Forenede Stater, 37204
    - Vanderbilt Breast Center at One Hundred Oaks
  - Nashville, Tennessee, Forenede Stater, 37208
    - Meharry Medical College
  - Ooltewah, Tennessee, Forenede Stater, 37363
    - Memorial GYN Plus
- Texas
  - Amarillo, Texas, Forenede Stater, 79106
    - The Don and Sybil Harrington Cancer Center
  - Dallas, Texas, Forenede Stater, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, Forenede Stater, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - Dallas, Texas, Forenede Stater, 75246
    - Texas Oncology at Baylor Charles A Sammons Cancer Center
  - Fort Sam Houston, Texas, Forenede Stater, 78234
    - Brooke Army Medical Center
  - Galveston, Texas, Forenede Stater, 77555-0565
    - University of Texas Medical Branch
  - Houston, Texas, Forenede Stater, 77030
    - M D Anderson Cancer Center
  - Houston, Texas, Forenede Stater, 77026-1967
    - Lyndon Baines Johnson General Hospital
  - Houston, Texas, Forenede Stater, 77030
    - Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
  - Houston, Texas, Forenede Stater, 77030
    - Memorial Hermann Texas Medical Center
  - Houston, Texas, Forenede Stater, 77030
    - Michael E DeBakey VA Medical Center
  - Houston, Texas, Forenede Stater, 77030
    - The Methodist Hospital System
  - Houston, Texas, Forenede Stater, 77094
    - MD Anderson Regional Care Center-Katy
  - Houston, Texas, Forenede Stater, 77030
    - Ben Taub General Hospital
  - League City, Texas, Forenede Stater, 77573
    - UTMB Cancer Center at Victory Lakes
  - Lubbock, Texas, Forenede Stater, 79410
    - Covenant Medical Center-Lakeside
  - Lubbock, Texas, Forenede Stater, 79430
    - Texas Tech University Health Sciences Center-Lubbock
  - Nassau Bay, Texas, Forenede Stater, 77058
    - MD Anderson Regional Care Center-Bay Area
  - San Antonio, Texas, Forenede Stater, 78229
    - University of Texas Health Science Center at San Antonio
  - Sugar Land, Texas, Forenede Stater, 77478
    - MD Anderson Regional Care Center-Sugar Land
  - The Woodlands, Texas, Forenede Stater, 77384
    - MD Anderson Regional Care Center-The Woodlands
- Utah
  - American Fork, Utah, Forenede Stater, 84003
    - American Fork Hospital / Huntsman Intermountain Cancer Center
  - Cedar City, Utah, Forenede Stater, 84720
    - Sandra L Maxwell Cancer Center
  - Logan, Utah, Forenede Stater, 84321
    - Logan Regional Hospital
  - Murray, Utah, Forenede Stater, 84107
    - Intermountain Medical Center
  - Ogden, Utah, Forenede Stater, 84403
    - McKay-Dee Hospital Center
  - Provo, Utah, Forenede Stater, 84604
    - Utah Valley Regional Medical Center
  - Saint George, Utah, Forenede Stater, 84770
    - Dixie Medical Center Regional Cancer Center
  - Salt Lake City, Utah, Forenede Stater, 84112
    - Huntsman Cancer Institute/University of Utah
  - Salt Lake City, Utah, Forenede Stater, 84106
    - Utah Cancer Specialists-Salt Lake City
  - Salt Lake City, Utah, Forenede Stater, 84143
    - LDS Hospital
  - South Jordan, Utah, Forenede Stater, 84009
    - South Jordan Health Center
- Vermont
  - Berlin, Vermont, Forenede Stater, 05602
    - Central Vermont Medical Center/National Life Cancer Treatment
  - Burlington, Vermont, Forenede Stater, 05401
    - University of Vermont Medical Center
  - Burlington, Vermont, Forenede Stater, 05405
    - University of Vermont College of Medicine
- Virginia
  - Charlottesville, Virginia, Forenede Stater, 22908
    - University of Virginia Cancer Center
  - Fredericksburg, Virginia, Forenede Stater, 22408
    - Hematology Oncology Associates of Fredericksburg Inc
  - Lynchburg, Virginia, Forenede Stater, 24501
    - Lynchburg Hematology-Oncology Clinic
  - Martinsville, Virginia, Forenede Stater, 24115
    - Memorial Hospital Of Martinsville
  - Mechanicsville, Virginia, Forenede Stater, 23116
    - Bon Secours Memorial Regional Medical Center
  - Midlothian, Virginia, Forenede Stater, 23114
    - Bon Secours Saint Francis Medical Center
  - Richmond, Virginia, Forenede Stater, 23298
    - Virginia Commonwealth University/Massey Cancer Center
  - Richmond, Virginia, Forenede Stater, 23230
    - Virginia Cancer Institute
  - Richmond, Virginia, Forenede Stater, 23226
    - Bon Secours Saint Mary's Hospital
  - South Hill, Virginia, Forenede Stater, 23970
    - VCU Community Memorial Health Center
  - Winchester, Virginia, Forenede Stater, 22601
    - Shenandoah Oncology Associates PC
- Washington
  - Aberdeen, Washington, Forenede Stater, 98520
    - Providence Regional Cancer System-Aberdeen
  - Anacortes, Washington, Forenede Stater, 98221
    - Cancer Care Center at Island Hospital
  - Auburn, Washington, Forenede Stater, 98001
    - MultiCare Auburn Medical Center
  - Bainbridge Island, Washington, Forenede Stater, 98110
    - Virginia Mason Bainbridge Island Medical Center
  - Bellevue, Washington, Forenede Stater, 98005
    - Swedish Cancer Institute-Eastside Oncology Hematology
  - Bellevue, Washington, Forenede Stater, 98004
    - Overlake Hospital Medical Center
  - Bellingham, Washington, Forenede Stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Bremerton, Washington, Forenede Stater, 98310
    - Harrison HealthPartners Hematology and Oncology-Bremerton
  - Bremerton, Washington, Forenede Stater, 98310
    - Harrison Medical Center
  - Burien, Washington, Forenede Stater, 98166
    - Highline Medical Center-Main Campus
  - Centralia, Washington, Forenede Stater, 98531
    - Providence Regional Cancer System-Centralia
  - Edmonds, Washington, Forenede Stater, 98026
    - Swedish Medical Center-Edmonds
  - Enumclaw, Washington, Forenede Stater, 98022
    - Saint Elizabeth Hospital
  - Everett, Washington, Forenede Stater, 98201
    - Providence Regional Cancer Partnership
  - Federal Way, Washington, Forenede Stater, 98002
    - Virginia Mason Federal Way Medical Center
  - Federal Way, Washington, Forenede Stater, 98003
    - Saint Francis Hospital
  - Gig Harbor, Washington, Forenede Stater, 98332
    - Tacoma/Valley Radiation Oncology Centers-Gig Harbor
  - Gig Harbor, Washington, Forenede Stater, 98335
    - MultiCare Gig Harbor Medical Park
  - Issaquah, Washington, Forenede Stater, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Forenede Stater, 99336
    - Kadlec Clinic Hematology and Oncology
  - Kennewick, Washington, Forenede Stater, 99336
    - Northwest Cancer Clinic
  - Kirkland, Washington, Forenede Stater, 98034
    - Seattle Cancer Care Alliance at EvergreenHealth
  - Lacey, Washington, Forenede Stater, 98503
    - Providence Regional Cancer System-Lacey
  - Lakewood, Washington, Forenede Stater, 98499
    - Saint Clare Hospital
  - Longview, Washington, Forenede Stater, 98632
    - PeaceHealth Saint John Medical Center
  - Lynnwood, Washington, Forenede Stater, 98036
    - Virginia Mason Lynnwood Medical Center
  - Mount Vernon, Washington, Forenede Stater, 98273
    - Skagit Valley Hospital Regional Cancer Care Center
  - Mount Vernon, Washington, Forenede Stater, 98274
    - Skagit Valley Hospital
  - Olympia, Washington, Forenede Stater, 98506-5166
    - Providence - Saint Peter Hospital
  - Olympia, Washington, Forenede Stater, 98507
    - Capital Medical Center
  - Port Townsend, Washington, Forenede Stater, 98368
    - Jefferson Healthcare
  - Poulsbo, Washington, Forenede Stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Poulsbo, Washington, Forenede Stater, 98370
    - Peninsula Cancer Center
  - Puyallup, Washington, Forenede Stater, 98372
    - MultiCare Good Samaritan Hospital
  - Puyallup, Washington, Forenede Stater, 98372
    - Tacoma/Valley Radiation Oncology Centers-Puyallup
  - Seattle, Washington, Forenede Stater, 98109
    - Fred Hutchinson Cancer Research Center
  - Seattle, Washington, Forenede Stater, 98109
    - Seattle Cancer Care Alliance
  - Seattle, Washington, Forenede Stater, 98195
    - University of Washington Medical Center
  - Seattle, Washington, Forenede Stater, 98101
    - Virginia Mason Medical Center
  - Seattle, Washington, Forenede Stater, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Forenede Stater, 98112
    - Kaiser Permanente Washington
  - Seattle, Washington, Forenede Stater, 98104
    - Minor and James Medical PLLC
  - Seattle, Washington, Forenede Stater, 98104
    - Pacific Gynecology Specialists
  - Seattle, Washington, Forenede Stater, 98122-4307
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forenede Stater, 98133
    - Seattle Cancer Care Alliance at Northwest Hospital
  - Shelton, Washington, Forenede Stater, 98584
    - Providence Regional Cancer System-Shelton
  - Spokane, Washington, Forenede Stater, 99204
    - Rockwood Cancer Treatment Center-DHEC-Downtown
  - Spokane, Washington, Forenede Stater, 99202
    - Cancer Care Northwest - Spokane South
  - Spokane, Washington, Forenede Stater, 99208
    - Spokane Valley Cancer Center-Mayfair
  - Spokane, Washington, Forenede Stater, 99216
    - Cancer Care Northwest-Valley
  - Spokane, Washington, Forenede Stater, 99218
    - Cancer Care Northwest-North Spokane
  - Spokane, Washington, Forenede Stater, 99218
    - Rockwood North Cancer Treatment Center
  - Spokane Valley, Washington, Forenede Stater, 99216
    - Rockwood Clinic Cancer Treatment Center-Valley
  - Tacoma, Washington, Forenede Stater, 98405
    - Northwest Medical Specialties PLLC
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Tacoma General Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - Tacoma/Valley Radiation Oncology Centers-Saint Joe's
  - Tacoma, Washington, Forenede Stater, 97405
    - Tacoma/Valley Radiation Oncology Centers-Jackson Hall
  - Tacoma, Washington, Forenede Stater, 98405
    - Franciscan Research Center-Northwest Medical Plaza
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Allenmore Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - Northwest NCI Community Oncology Research Program
  - Tacoma, Washington, Forenede Stater, 98405
    - Saint Joseph Medical Center
  - Vancouver, Washington, Forenede Stater, 98686
    - Legacy Salmon Creek Hospital
  - Vancouver, Washington, Forenede Stater, 98664
    - PeaceHealth Southwest Medical Center
  - Vancouver, Washington, Forenede Stater, 98684
    - Compass Oncology Vancouver
  - Walla Walla, Washington, Forenede Stater, 99362
    - Providence Saint Mary Regional Cancer Center
  - Wenatchee, Washington, Forenede Stater, 98801
    - Wenatchee Valley Hospital and Clinics
  - Yakima, Washington, Forenede Stater, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
  - Yelm, Washington, Forenede Stater, 98597
    - Providence Regional Cancer System-Yelm
- West Virginia
  - Bridgeport, West Virginia, Forenede Stater, 26330
    - United Hospital Center
  - Charleston, West Virginia, Forenede Stater, 25304
    - West Virginia University Charleston
  - Huntington, West Virginia, Forenede Stater, 25702
    - Saint Mary's Medical Center
  - Martinsburg, West Virginia, Forenede Stater, 25401
    - WVUH-East City Hospital
  - Morgantown, West Virginia, Forenede Stater, 26506
    - West Virginia University Healthcare
  - Parkersburg, West Virginia, Forenede Stater, 26101
    - Camden-Clark Memorial Hospital
- Wisconsin
  - Antigo, Wisconsin, Forenede Stater, 54409
    - Langlade Hospital and Cancer Center
  - Appleton, Wisconsin, Forenede Stater, 54913
    - Fox Valley Hematology and Oncology SC-Appleton
  - Burlington, Wisconsin, Forenede Stater, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Chippewa Falls, Wisconsin, Forenede Stater, 54729
    - Marshfield Clinic-Chippewa Center
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Sacred Heart Hospital
  - Fond Du Lac, Wisconsin, Forenede Stater, 54937
    - Aurora Health Center-Fond du Lac
  - Germantown, Wisconsin, Forenede Stater, 53022
    - Aurora Health Care Germantown Health Center
  - Grafton, Wisconsin, Forenede Stater, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Forenede Stater, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Forenede Stater, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Green Bay Oncology Limited at Saint Mary's Hospital
  - Green Bay, Wisconsin, Forenede Stater, 54301-3526
    - Green Bay Oncology at Saint Vincent Hospital
  - Janesville, Wisconsin, Forenede Stater, 53547
    - Mercy Health System
  - Johnson Creek, Wisconsin, Forenede Stater, 53038
    - UW Cancer Center Johnson Creek
  - Kenosha, Wisconsin, Forenede Stater, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Medical Center
  - Ladysmith, Wisconsin, Forenede Stater, 54848
    - Marshfield Clinic - Ladysmith Center
  - Madison, Wisconsin, Forenede Stater, 53792
    - University of Wisconsin Hospital and Clinics
  - Manitowoc, Wisconsin, Forenede Stater, 54221
    - Holy Family Memorial Hospital
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Bay Area Medical Center
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Vince Lombardi Cancer Clinic-Marinette
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Clinic
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Medical Center
  - Menomonee Falls, Wisconsin, Forenede Stater, 53051
    - Community Memorial Hospital
  - Milwaukee, Wisconsin, Forenede Stater, 53226
    - Froedtert and The Medical College of Wisconsin
  - Milwaukee, Wisconsin, Forenede Stater, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53233
    - Aurora Sinai Medical Center
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Clinic-Minocqua Center
  - Mukwonago, Wisconsin, Forenede Stater, 53149
    - ProHealth D N Greenwald Center
  - New Richmond, Wisconsin, Forenede Stater, 54017
    - Cancer Center of Western Wisconsin
  - Oconomowoc, Wisconsin, Forenede Stater, 53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oconto Falls, Wisconsin, Forenede Stater, 54154
    - Green Bay Oncology - Oconto Falls
  - Oshkosh, Wisconsin, Forenede Stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forenede Stater, 53406
    - Aurora Cancer Care-Racine
  - Rhinelander, Wisconsin, Forenede Stater, 54501
    - Saint Mary's Hospital
  - Rhinelander, Wisconsin, Forenede Stater, 54501
    - Marshfield Clinic at James Beck Cancer Center
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Lakeview Medical Center-Marshfield Clinic
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Clinic-Rice Lake Center
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - HSHS Saint Nicholas Hospital
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Saint Michael's Hospital
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Marshfield Clinic Cancer Care at Saint Michael's Hospital
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
    - Saint Vincent Hospital Cancer Center at Sturgeon Bay
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235
    - Green Bay Oncology - Sturgeon Bay
  - Summit, Wisconsin, Forenede Stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forenede Stater, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - UW Cancer Center at ProHealth Care
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - ProHealth Waukesha Memorial Hospital
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - Aurora Cancer Care-Waukesha
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Aspirus Regional Cancer Center
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Marshfield Clinic-Wausau Center
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - West Allis, Wisconsin, Forenede Stater, 53227
    - Aurora West Allis Medical Center
  - West Bend, Wisconsin, Forenede Stater, 53095
    - The Alyce and Elmore Kraemer Cancer Care Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Diagnostic and Treatment Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Clinic - Weston Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Saint Clare's Hospital
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Aspirus UW Cancer Center
- Wyoming
  - Casper, Wyoming, Forenede Stater, 82609
    - Rocky Mountain Oncology
  - Cheyenne, Wyoming, Forenede Stater, 82001
    - Cheyenne Regional Medical Center-West
  - Cody, Wyoming, Forenede Stater, 82414
    - Big Horn Basin Cancer Center
  - Cody, Wyoming, Forenede Stater, 82414
    - Billings Clinic-Cody
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

25 år og ældre (VOKSEN, OLDER_ADULT)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inklusionskriterier:

Patienter skal opfylde alle SCREENING/FØR-SCREENING og DELUNDERSØGELSESREGISTRERING FÆLLES KVALIFIKATIONSKRITERIER som specificeret i S1400: Fase II/III biomarkørdrevet masterprotokol for tidligere behandlet planocellulært lungekræft (lungekort)
Patienter skal tildeles S1400D
Patienter må ikke tage, eller planlægge at tage, mens de er i protokolbehandling og i 14 dage efter den sidste dosis af undersøgelsesbehandling, lægemidler, naturlægemidler eller fødevarer, der er kendt for at være stærke/moderate CYP3A4- eller CYP2D6-hæmmere og/eller inducere.
Patienter må ikke have fået nitrosourea eller mitomycin C inden for 42 dage før registrering af delstudiet
Patienter må ikke tidligere have været udsat for et middel med FGFR-hæmning som dets primære farmakologi
Patienter må ikke have et gennemsnitligt hvilekorrigeret QT-interval (QTc) > 450 msek opnået fra 3 på hinanden følgende elektrokardiogrammer (EKG'er); udført inden for 28 dage før delstudieregistrering; patienter må ikke have nogen klinisk vigtige abnormiteter i rytme, overledning eller morfologi af hvile-EKG (f. komplet venstre grenblok, tredje grads hjerteblok); patienter må ikke have nogen faktorer, der øger risikoen for QTc-forlængelse eller risiko for arytmiske hændelser såsom hjertesvigt, hypokaliæmi, medfødt langt QT-syndrom, familiehistorie med langt QT-syndrom eller uforklarlig pludselig død under 40 år
Patienter må ikke planlægge at modtage samtidig medicin, der vides at forlænge QT-intervallet
Patienter skal kunne tage oral medicin; patienten må ikke have nogen svækkelse af mave-tarmfunktionen eller mave-tarmsygdom, der kan ændre absorptionen af AZD4547 væsentligt (f. ulcerosa, ukontrolleret kvalme, opkastning, diarré, malabsorptionssyndrom eller tyndtarmsresektion)
Patienter må ikke have en historie med overfølsomhed over for aktive eller inaktive hjælpestoffer af AZD4547 eller lægemidler med en lignende kemisk struktur eller klasse som AZD4547
Patienter må ikke have nogen af følgende oftalmologiske kriterier: aktuelle beviser eller tidligere historie med retinal pigmenteret epitelløsning (RPED); tidligere laserbehandling eller intraokulær injektion til behandling af makuladegeneration; aktuelle beviser eller tidligere historie med tør eller våd aldersrelateret makuladegeneration; nuværende bevis eller tidligere historie med retinal veneokklusion (RVO); aktuelle beviser eller tidligere historie med retinale degenerative sygdomme (f. arvelig); eller aktuelle beviser eller tidligere historie om enhver anden klinisk relevant chorioretinal defekt
Patienter skal have en øjenundersøgelse udført inden for 28 dage før registrering af delstudiet; patienter med ukontrolleret glaukom eller intraokulært tryk >= 21 mm Hg ved screening bør henvises til oftalmologisk behandling og tilstanden kontrolleres før registrering
Patienterne skal have albumin, urinanalyse og Troponin I opnået inden for 7 dage før registrering af delstudiet
Patienter skal have korrigeret calcium og fosfat < øvre grænse eller normal (ULN) opnået inden for 7 dage før registrering af delstudiet
Patienter skal have udført multigated acquisition (MUGA)/ekkokardiogram inden for 28 dage før registrering af delstudiet
Patienter skal også tilbydes deltagelse i bankvirksomhed til fremtidig brug af prøver
TRIN 2 TIL AZD4547 REGISTRERING:
Patienterne skal have udviklet sig på arm 2 (docetaxel) i denne delundersøgelse
Patienter må ikke have modtaget nogen tidligere systemisk behandling (systemisk kemoterapi, immunterapi eller forsøgslægemiddel) inden for 21 dage før genregistrering; patienter skal være kommet sig (=< grad 1) fra eventuelle bivirkninger fra tidligere behandling
Patienter skal have målbar sygdom dokumenteret ved computertomografi (CT) eller magnetisk resonansbilleddannelse (MRI); CT'en fra en kombineret positronemissionstomografi (PET)/CT kan kun bruges til at dokumentere ikke-målbar sygdom, medmindre den er af diagnostisk kvalitet; målbar sygdom skal vurderes inden for 28 dage før genregistrering; pleurale effusioner, ascites og laboratorieparametre er ikke acceptable som det eneste tegn på sygdom; ikke-målbar sygdom skal vurderes inden for 42 dage før genregistrering; al sygdom skal vurderes og dokumenteres på Baseline Tumor Assessment Form; patienter, hvis eneste målbare sygdom er inden for en tidligere stråleterapiport, skal demonstrere klart fremadskridende sygdom (efter den behandlende investigators mening) før registrering
Patienter skal have en CT- eller MR-scanning af hjernen for at evaluere for sygdom i centralnervesystemet (CNS) inden for 42 dage før trin 2 genregistrering; patienten må ikke have leptomeningeal sygdom, rygmarvskompression eller hjernemetastaser, medmindre: (1) metastaser er blevet lokalt behandlet og er forblevet klinisk kontrollerede og asymptomatiske i mindst 14 dage efter behandling før genregistrering, OG (2) patienten ikke har nogen resterende neurologisk dysfunktion og har været ude af kortikosteroider i mindst 24 timer før genregistrering
Patienter må ikke planlægge at modtage samtidig kemoterapi, immunterapi, biologisk eller hormonbehandling til cancerbehandling; Samtidig brug af hormoner til ikke-kræftrelaterede tilstande (f.eks. insulin til diabetes og hormonsubstitutionsterapi) er acceptabel
Patienter skal have albumin, urinanalyse og Troponin I opnået inden for 7 dage før registrering af delstudie
Patienterne skal have korrigeret calcium og fosfat < ULN opnået inden for 7 dage før registrering af delstudiet
Patienter skal have udført MUGA/ekkokardiogram inden for 28 dage før delstudieregistrering
Patienter må ikke have nogen af følgende oftalmologiske kriterier: aktuelle beviser eller tidligere historie med retinal pigmenteret epitelløsning (RPED); tidligere laserbehandling eller intraokulær injektion til behandling af makuladegeneration; aktuelle beviser eller tidligere historie med tør eller våd aldersrelateret makuladegeneration; nuværende bevis eller tidligere historie med retinal veneokklusion (RVO); aktuelle beviser eller tidligere historie med retinale degenerative sygdomme (f. arvelig); eller aktuelle beviser eller tidligere historie om enhver anden klinisk relevant chorioretinal defekt; patienter skal have en øjenundersøgelse udført inden for 28 dage før trin 2 genregistrering; patienter med ukontrolleret glaukom eller intraokulært tryk >= 21 mm Hg ved screening bør henvises til oftalmologisk behandling og tilstanden kontrolleres før crossover-registrering
Patienter må ikke tage, eller planlægge at tage, mens de er i protokolbehandling og i 14 dage efter den sidste dosis af undersøgelsesbehandling, lægemidler, naturlægemidler eller fødevarer, der er kendt for at være stærke/moderat CYP3A4- eller CYP2D6-substrater
Patienter må ikke have et gennemsnitligt hvilekorrigeret QT-interval (QTc) > 450 msek opnået fra 3 på hinanden følgende elektrokardiogrammer (EKG'er); udført inden for 28 dage før trin 2 genregistrering; patienter må ikke have nogen klinisk vigtige abnormiteter i rytme, overledning eller morfologi af hvile-EKG (f. komplet venstre grenblok, tredje grads hjerteblok); patienter må ikke have nogen faktorer, der øger risikoen for QTc-forlængelse eller risiko for arytmiske hændelser såsom hjertesvigt, hypokaliæmi, medfødt langt QT-syndrom, familiehistorie med langt QT-syndrom eller uforklarlig pludselig død under 40 år
Absolut neutrofiltal (ANC) >= 1.500/mcl opnået inden for 28 dage før trin 2 genregistrering
Blodpladetal >= 100.000 mcl opnået inden for 28 dage før trin 2 genregistrering
Hæmoglobin >= 9 g/dL opnået inden for 28 dage før trin 2 genregistrering
Serumbilirubin =< institutionel øvre normalgrænse (IULN); for patienter med levermetastaser skal bilirubin være =< 5 x IULN inden for 28 dage før trin 2 genregistrering
Enten alaninaminotransferase (ALT) eller aspartataminotransferase (AST) =< 2 x IULN inden for 28 dage før trin 2 genregistrering (hvis både ALT og ASAT udføres, skal begge være =< 2 IULN); for patienter med levermetastaser skal enten ALAT eller ASAT være =< 5 x IULN (hvis både ALAT og ASAT udføres, skal begge være =< 5 x IULN)
Patienter skal have en serumkreatinin =< IULN ELLER målt eller beregnet kreatininclearance >= 50 ml/min ved hjælp af Cockroft-Gault-formlen
Patienter skal have Zubrod præstationsstatus på 0-1 dokumenteret inden for 28 dage før trin 2 genregistrering
Patienter må ikke have nogen grad III/IV hjertesygdom som defineret af New York Heart Association Criteria (dvs. patienter med hjertesygdom, der resulterer i markant begrænsning af fysisk aktivitet eller resulterer i manglende evne til at udøve fysisk aktivitet uden ubehag), ustabil angina pectoris og myokardieinfarkt inden for 6 måneder eller alvorlig ukontrolleret hjertearytmi
Patienter må ikke have dokumenteret tegn på akut hepatitis eller have en aktiv eller ukontrolleret infektion
Patienter med en kendt anamnese med human immundefektvirus (HIV) seropositivitet: 1. Skal have en upåviselig viral belastning ved brug af standard HIV-assays i klinisk praksis; 2. Skal have cluster of differentiation (CD)4 count >= 400/mcL; 3. Må ikke kræve profylakse for nogen opportunistiske infektioner (dvs. svampe-, mycobacterium avium-kompleks [mAC] eller pneumocystis pneumoni [PCP]-profylakse); 4. Må ikke være nydiagnosticeret inden for 12 måneder før genregistrering
Forstudiehistorie og fysisk eksamen skal indhentes inden for 28 dage før genregistrering
Ingen anden tidligere malignitet er tilladt med undtagelse af følgende: tilstrækkeligt behandlet basalcelle- eller planocellulær hudcancer, in situ livmoderhalskræft, tilstrækkeligt behandlet stadium I eller II cancer, hvorfra patienten i øjeblikket er i fuldstændig remission, eller enhver anden cancer, hvorfra patienten har været sygdomsfri i fem år
Patienter må ikke være gravide eller ammende; kvinder/mænd med reproduktionspotentiale skal have accepteret at bruge en effektiv præventionsmetode; en kvinde anses for at have "reproduktionspotentiale", hvis hun har haft menstruation på noget tidspunkt i de foregående 12 på hinanden følgende måneder; ud over rutinepræventionsmetoder omfatter "effektiv prævention" også heteroseksuel cølibat og kirurgi beregnet til at forhindre graviditet (eller med en bivirkning af graviditetsforebyggelse) defineret som en hysterektomi, bilateral ooforektomi eller bilateral tubal ligering; men hvis en tidligere cølibatpatient på noget tidspunkt vælger at blive heteroseksuelt aktiv i løbet af tidsperioden for brug af præventionsforanstaltninger, der er beskrevet i protokollen, er han/hun ansvarlig for at påbegynde præventionsforanstaltninger
Som en del af registreringsprocessen for Oncology Patient Enrollment Network (OPEN) oplyses den behandlende institutions identitet for at sikre, at den aktuelle (inden for 365 dage) dato for institutionsbedømmelsesudvalgets godkendelse af denne undersøgelse er blevet indtastet i systemet
Patienter med nedsat beslutningsevne er kvalificerede, så længe deres neurologiske eller psykologiske tilstand ikke udelukker deres sikre deltagelse i undersøgelsen (f.eks. sporing af pilleforbrug og rapportering af uønskede hændelser til investigator)
Patienterne skal informeres om undersøgelsens karakter af denne undersøgelse og skal underskrive og give skriftligt informeret samtykke i overensstemmelse med institutionelle og føderale retningslinjer

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: BEHANDLING
Tildeling: NON_RANDOMIZED
Interventionel model: PARALLEL
Maskning: INGEN

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
EKSPERIMENTEL: Arm I - AZD4547 Deltagerne modtager FGFR-hæmmer AZD4547 PO BID på dag 1-21. Kurser gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.	Andet: Laboratoriebiomarkøranalyse Korrelative undersøgelser Medicin: FGFR-hæmmer AZD4547 Givet PO Andre navne: AZD4547
EKSPERIMENTEL: Arm II - Docetaxel Deltagerne modtager docetaxel IV på dag 1. Kurser gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet. Efter progression kan deltagere være berettiget til at omregistrere sig til Arm III. -lukket for optjening 18.12.2015	Andet: Laboratoriebiomarkøranalyse Korrelative undersøgelser Medicin: Docetaxel Givet IV Andre navne: Taxotere Docecad RP56976 Taxotere injektionskoncentrat
EKSPERIMENTEL: Arm III - AZD4547 omregistrering Deltagere i Arm II, der er kvalificeret til genregistrering, modtager FGFR-hæmmer AZD4547 PO BID på dag 1-21. Kurser gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.	Andet: Laboratoriebiomarkøranalyse Korrelative undersøgelser Medicin: FGFR-hæmmer AZD4547 Givet PO Andre navne: AZD4547

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Objektiv svarprocent (bekræftet og ubekræftet, fuldstændig og delvis) Tidsramme: Fra registreringsdato til maksimalt 2 år og 4 måneder eller død.	Procentdelen af deltagere med bekræftet og ubekræftet, delvis respons og fuldstændig respons på behandling med AZD4547 pr. responsevalueringskriterier i solide tumorer (RECIST 1.1). Evalueringskriterier pr. respons i solide tumorer (RECIST v1.1) for mållæsioner og vurderet ved MR: Komplet respons (CR), forsvinden af alle mållæsioner; Delvis respons (PR), >=30 % fald i summen af den længste diameter af mållæsioner; Samlet respons (OR) = CR + PR. Det var forudspecificeret, at kun AZD4547-armen ville blive analyseret på grund af fjernelse af docetaxel som standardbehandlingsbehandling	Fra registreringsdato til maksimalt 2 år og 4 måneder eller død.

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Varighed af respons blandt patienter, der opnår en fuldstændig respons eller delvis respons ved responsevalueringskriterier i solide tumorer 1.1 Tidsramme: Fra registreringsdato til maksimalt 2 år og 4 måneder eller død.	Fra datoen for første dokumentation af respons (komplet eller delvis) til dato for første dokumentation for progression vurderet ved lokal gennemgang, eller symptomatisk forværring eller død på grund af en hvilken som helst årsag blandt patienter, der opnår fuldstændig eller delvis respons i henhold til RECIST v1.1. Evalueringskriterier pr. respons i solide tumorer (RECIST v1.1) for mållæsioner og vurderet ved MR: Komplet respons (CR), forsvinden af alle mållæsioner; Delvis respons (PR), >=30 % fald i summen af den længste diameter af mållæsioner; Samlet respons (OR) = CR + PR. Progression defineres ved hjælp af Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1), som en stigning på 20 % i summen af den længste diameter af mållæsioner eller en målbar stigning i en ikke-mållæsion eller forekomsten af nye læsioner. Det var forudspecificeret, at kun AZD4547-armen ville blive analyseret på grund af fjernelse af docetaxel som standardbehandlingsbehandling	Fra registreringsdato til maksimalt 2 år og 4 måneder eller død.
Samlet overlevelse Tidsramme: Fra registreringsdato til maksimalt 2 år og 4 måneder eller død	Fra datoen for delstudieregistrering på studiet til dødsfald uanset årsag. Observationer for deltagere, der sidst vidstes for at være i live, blev censureret. Det var forudspecificeret, at kun AZD4547-armen ville blive analyseret på grund af fjernelse af docetaxel som standardbehandlingsbehandling	Fra registreringsdato til maksimalt 2 år og 4 måneder eller død
Progressionsfri overlevelse Tidsramme: Fra registreringsdato til maksimalt 2 år og 4 måneder eller død.	Fra dato for delstudieregistrering til dato for første dokumentation for progression eller symptomatisk forværring eller død på grund af en hvilken som helst årsag. Per responsevalueringskriterier i solide tumorer (RECIST v1.1) defineres progression ved hjælp af responsevalueringskriterier i solide tumorer (RECIST v1.1), som en stigning på 20 % i summen af den længste diameter af mållæsioner, eller en målbar stigning i en ikke-mållæsion eller fremkomsten af nye læsioner. Det var forudspecificeret, at kun AZD4547-armen ville blive analyseret på grund af fjernelse af docetaxel som standardbehandlingsbehandling	Fra registreringsdato til maksimalt 2 år og 4 måneder eller død.
Antal deltagere med gr 3 til 5 uønskede hændelser, der er relateret til undersøgelsesstoffer Tidsramme: Varighed af behandling og opfølgning, op til 2 år og 4 måneder efter registrering eller død.	Bivirkninger (AE'er) rapporteres i henhold til CTCAE version 5.0. Kun uønskede hændelser, der muligvis, sandsynligvis eller helt sikkert er relateret til undersøgelseslægemidlet, er rapporteret. Det var forudspecificeret, at kun AZD4547-armen ville blive analyseret på grund af fjernelse af docetaxel som standardbehandlingsbehandling	Varighed af behandling og opfølgning, op til 2 år og 4 måneder efter registrering eller død.

Andre resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Skærmens succesrate Tidsramme: Op til 3 år	Vil blive overvåget af procentdelen af screenede patienter, der tilmelder sig et terapeutisk delstudie.	Op til 3 år
Behandlingsarm Randomisering Acceptrate Tidsramme: Op til 3 år	Vil blive overvåget af procentdelen af patienter, der modtager mindst én dosis af den behandling, de er randomiseret til at modtage.	Op til 3 år

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Southwest Oncology Group

Samarbejdspartnere

National Cancer Institute (NCI)

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (FAKTISKE)

1. oktober 2014

Primær færdiggørelse (FAKTISKE)

1. januar 2017

Studieafslutning (FAKTISKE)

1. oktober 2019

Datoer for studieregistrering

Først indsendt

14. november 2016

Først indsendt, der opfyldte QC-kriterier

14. november 2016

Først opslået (SKØN)

16. november 2016

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (FAKTISKE)

27. maj 2021

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

25. maj 2021

Sidst verificeret

1. maj 2021

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

S1400D (CTEP)
U10CA180888 (U.S. NIH-bevilling/kontrakt)
NCI-2014-01381 (REGISTRERING: CTRP (Clinical Trial Reporting Program))

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Tilbagevendende planocellulært lungekarcinom

AHS Cancer Control Alberta
Cross Cancer Institute

Afsluttet

Fase II-forsøg med konsoliderende thoraxstrålebehandling for småcellet lungekræft i omfattende stadier

Omfattende Stage Small Cel Lung Cancer

Canada
National Cancer Institute (NCI)

Afsluttet

Navitoclax og Vistusertib til behandling af patienter med recidiverende småcellet lungekræft og andre solide tumorer

Ildfast malignt fast neoplasma | Tilbagevendende malignt fast neoplasma | Metastatisk malignt fast neoplasma | Uoprettelig fast neoplasma | Tilbagevendende småcellet lungekarcinom | Stadie IIIA Lunge småcellet karcinom AJCC v7 | Stadie IIIB Lunge småcellet karcinom AJCC v7 | Stadie IV lunge småcellet... og andre forhold

Forenede Stater

Kliniske forsøg med Laboratoriebiomarkøranalyse

Liao Jian An

Rekruttering

Meridianenergiændringer hos patienter med hoved- og nakkekræft efter kemoterapi eller strålebehandling

Hoved- og halskræft

Taiwan
Fondation Lenval

Trukket tilbage

Indflydelse af træthed på gangmønsteret hos patienter med cerebral parese.

Cerebral Parese

Frankrig
Progenity, Inc.

Afsluttet

Udvidet ikke-invasiv genomisk medicinsk vurdering: Enigma-undersøgelsen

Downs syndrom | Aneuploidi | DiGeorges syndrom | Turners syndrom | Klinefelters syndrom | Kromosom sletning | Edwards syndrom | Patau syndrom

Forenede Stater
IRCCS Eugenio Medea

Rekruttering

Biomarkørers baner for tidlig intervention hos søskende til børn med autismespektrumforstyrrelse

Autismespektrumforstyrrelse | Tidlig indsats

Italien
Oregon Health and Science University
4DMedical

Tilmelding efter invitation

Ventilationsubalancer ved let til moderat kronisk obstruktiv lungesygdom (VAPOR)

Lungesygdomme | KOL | Luftvejssygdom | Dyspnø

Forenede Stater
IRCCS Eugenio Medea

Rekruttering

Bekræft præstationen i klinisk praksis af den fordybende Virtual Reality Platform GRAIL (Gait Real-time Analysis Interactive Lab)

Cerebral Parese | Erhvervet hjerneskade

Italien
Modarres Hospital

Afsluttet

Renal parenkymal kernenålbiopsi

Komplikationer | Billedstyret biopsi | Nyre Glomerulus

Iran, Islamisk Republik
Healthy.io Ltd.

Afsluttet

[Prøvning af enhed, der ikke er godkendt eller godkendt af U.S. FDA]

Albuminuri

Forenede Stater
Medwave Estudios Limitada
Asociación Chilena de Seguridad

Ukendt

Diagnostisk værdi af arbejdsbelastningsanalyseinstrument til at påvise erhvervsmæssige risici ved muskel- og skelettilstande i øvre lemmer (ACT-ACHS)

Erhvervsmæssig eksponering | Muskuloskeletal sygdom

Chile
Duke University

Trukket tilbage

Point of Care-test for at forbedre overvågningen af LVAD-patienter

Antikoagulation og trombose Point of Care Test (AT-POCT)

Forenede Stater

Lung-MAP: AZD4547 som andenlinjeterapi til behandling af FGFR-positive patienter med tilbagevendende trin IV planocellulær lungekræft

Et fase II-studie af AZD4547 for tidligere behandlede FGFR-positive patienter med trin IV planocellulært lungekræft (Lung-Map Sub-studie)

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Køn, der er berettiget til at studere

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Andre resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Datoer for undersøgelser

Studer store datoer

Studiestart (FAKTISKE)

Primær færdiggørelse (FAKTISKE)

Studieafslutning (FAKTISKE)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (SKØN)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (FAKTISKE)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Kliniske forsøg med Tilbagevendende planocellulært lungekarcinom

Kliniske forsøg med Laboratoriebiomarkøranalyse

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Lebanon

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer