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Forenklet patientbehandlingsstrategi til at reducere tidlig død hos patienter med akut promyelocytisk leukæmi

12. maj 2026 opdateret af: ECOG-ACRIN Cancer Research Group

En forenklet patientbehandlingsstrategi for at reducere tidlige dødsfald ved akut promyelocytisk leukæmi (APL)

Dette kliniske forsøg undersøger, hvor godt forenklet patientbehandlingsstrategi virker til at mindske tidlig død hos patienter med akut promyelocytisk leukæmi. Implementering af forenklede retningslinjer for akut promyelocytisk leukæmi sammen med støtte fra eksperter i akut promyelocytisk leukæmi kan reducere dødsfald og forbedre overlevelsen.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆRE MÅL:

I. For at vurdere, om den foreslåede patientbehandlingsstrategi, der inkluderer brug af forenklede retningslinjer sammen med akut promyelocytisk leukæmi (APL) ekspertstøtte, reducerer en måneds induktionsdødelighed fra 30 % til under 15 %.

SEKUNDÆRE MÅL:

I. At vurdere den samlede overlevelse 1 år efter optjening er gennemført. II. At vurdere forekomst og sværhedsgrad af differentieringssyndrom. III. At korrelere resultater med tid til påbegyndelse af all-trans retinsyre (ATRA) fra diagnose eller mistanke om diagnose.

IV. At sammenligne resultater mellem akademiske og samfundscentre separat. V. At evaluere faktorer forbundet med resultatet.

OMRIDS:

Patienter modtager standardbehandling for APL. Patienter? læger diskuterer regelmæssigt med en APL-ekspert for at identificere og behandle behandling.

Efter diagnosen følges patienterne op i 1 år.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

202

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Forenede Stater
    • Alaska
      • Fairbanks, Alaska, Forenede Stater, 99701
        • Fairbanks Memorial Hospital
    • California
      • Anaheim, California, Forenede Stater, 92806
        • Kaiser Permanente-Anaheim
      • Antioch, California, Forenede Stater, 94531
        • Kaiser Permanente-Deer Valley Medical Center
      • Baldwin Park, California, Forenede Stater, 91706
        • Kaiser Permanente-Baldwin Park
      • Bellflower, California, Forenede Stater, 90706
        • Kaiser Permanente-Bellflower
      • Fontana, California, Forenede Stater, 92335
        • Kaiser Permanente-Fontana
      • Fremont, California, Forenede Stater, 94538
        • Kaiser Permanente-Fremont
      • Fresno, California, Forenede Stater, 93720
        • Kaiser Permanente-Fresno
      • Fresno, California, Forenede Stater, 93720
        • Fresno Cancer Center
      • Harbor City, California, Forenede Stater, 90710
        • Kaiser Permanente - Harbor City
      • Irvine, California, Forenede Stater, 92618
        • Kaiser Permanente-Irvine
      • Los Angeles, California, Forenede Stater, 90027
        • Kaiser Permanente Los Angeles Medical Center
      • Los Angeles, California, Forenede Stater, 90034
        • Kaiser Permanente-Cadillac
      • Modesto, California, Forenede Stater, 95356
        • Kaiser Permanente-Modesto
      • Oakland, California, Forenede Stater, 94611
        • Kaiser Permanente-Oakland
      • Oakland, California, Forenede Stater, 94611
        • Kaiser Permanente Oakland-Broadway
      • Ontario, California, Forenede Stater, 91761
        • Kaiser Permanente-Ontario
      • Panorama City, California, Forenede Stater, 91402
        • Kaiser Permanente - Panorama City
      • Rancho Cordova, California, Forenede Stater, 95670
        • Kaiser Permanente-Rancho Cordova Cancer Center
      • Redwood City, California, Forenede Stater, 94063
        • Kaiser Permanente-Redwood City
      • Richmond, California, Forenede Stater, 94801
        • Kaiser Permanente-Richmond
      • Riverside, California, Forenede Stater, 92505
        • Kaiser Permanente-Riverside
      • Rohnert Park, California, Forenede Stater, 94928
        • Rohnert Park Cancer Center
      • Roseville, California, Forenede Stater, 95678
        • The Permanente Medical Group-Roseville Radiation Oncology
      • Roseville, California, Forenede Stater, 95661
        • Kaiser Permanente-Roseville
      • Sacramento, California, Forenede Stater, 95814
        • Kaiser Permanente Downtown Commons
      • Sacramento, California, Forenede Stater, 95823
        • Kaiser Permanente-South Sacramento
      • Sacramento, California, Forenede Stater, 95823
        • South Sacramento Cancer Center
      • Sacramento, California, Forenede Stater, 95825
        • Kaiser Permanente - Sacramento
      • San Diego, California, Forenede Stater, 92120
        • Kaiser Permanente-San Diego Zion
      • San Diego, California, Forenede Stater, 92108
        • Kaiser Permanente-San Diego Mission
      • San Francisco, California, Forenede Stater, 94115
        • Kaiser Permanente-San Francisco
      • San Jose, California, Forenede Stater, 95119
        • Kaiser Permanente-Santa Teresa-San Jose
      • San Leandro, California, Forenede Stater, 94577
        • Kaiser Permanente San Leandro
      • San Marcos, California, Forenede Stater, 92078
        • Kaiser Permanente-San Marcos
      • San Rafael, California, Forenede Stater, 94903
        • Kaiser San Rafael-Gallinas
      • Santa Clara, California, Forenede Stater, 95051
        • Kaiser Permanente Medical Center - Santa Clara
      • Santa Rosa, California, Forenede Stater, 95403
        • Kaiser Permanente-Santa Rosa
      • South San Francisco, California, Forenede Stater, 94080
        • Kaiser Permanente Cancer Treatment Center
      • South San Francisco, California, Forenede Stater, 94080
        • Kaiser Permanente-South San Francisco
      • Stockton, California, Forenede Stater, 95210
        • Kaiser Permanente-Stockton
      • Vacaville, California, Forenede Stater, 95688
        • Kaiser Permanente Medical Center-Vacaville
      • Vallejo, California, Forenede Stater, 94589
        • Kaiser Permanente-Vallejo
      • Walnut Creek, California, Forenede Stater, 94596
        • Kaiser Permanente-Walnut Creek
      • Woodland Hills, California, Forenede Stater, 91367
        • Kaiser Permanente-Woodland Hills
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80012
        • Rocky Mountain Cancer Centers-Aurora
      • Aurora, Colorado, Forenede Stater, 80012
        • The Medical Center of Aurora
      • Boulder, Colorado, Forenede Stater, 80301
        • Boulder Community Hospital
      • Boulder, Colorado, Forenede Stater, 80304
        • Rocky Mountain Cancer Centers-Boulder
      • Centennial, Colorado, Forenede Stater, 80112
        • Rocky Mountain Cancer Centers - Centennial
      • Denver, Colorado, Forenede Stater, 80218
        • Presbyterian - Saint Lukes Medical Center - Health One
      • Denver, Colorado, Forenede Stater, 80218
        • SCL Health Saint Joseph Hospital
      • Denver, Colorado, Forenede Stater, 80220
        • Rose Medical Center
      • Denver, Colorado, Forenede Stater, 80218
        • Rocky Mountain Cancer Centers-Midtown
      • Denver, Colorado, Forenede Stater, 80220
        • Rocky Mountain Cancer Centers-Rose
      • Denver, Colorado, Forenede Stater, 80204
        • Denver Health Medical Center
      • Denver, Colorado, Forenede Stater, 80218
        • Colorado Blood Cancer Institute
      • Denver, Colorado, Forenede Stater, 80204
        • Cancer Center of Colorado at Sloan's Lake
      • Denver, Colorado, Forenede Stater, 80209
        • The Women's Imaging Center
      • Denver, Colorado, Forenede Stater, 80206
        • National Jewish Health-Main Campus
      • Englewood, Colorado, Forenede Stater, 80113
        • Mountain Blue Cancer Care Center - Swedish
      • Englewood, Colorado, Forenede Stater, 80113
        • Swedish Medical Center
      • Golden, Colorado, Forenede Stater, 80401
        • National Jewish Health-Western Hematology Oncology
      • Grand Junction, Colorado, Forenede Stater, 81501
        • Saint Mary's Hospital and Regional Medical Center
      • Greeley, Colorado, Forenede Stater, 80631
        • North Colorado Medical Center
      • Greenwood Village, Colorado, Forenede Stater, 80111
        • Rocky Mountain Cancer Centers-Greenwood Village
      • Lafayette, Colorado, Forenede Stater, 80026
        • Good Samaritan Medical Center
      • Littleton, Colorado, Forenede Stater, 80120
        • Rocky Mountain Cancer Centers-Littleton
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Sky Ridge Medical Center
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Rocky Mountain Cancer Centers-Sky Ridge
      • Loveland, Colorado, Forenede Stater, 80539
        • McKee Medical Center
      • Thornton, Colorado, Forenede Stater, 80260
        • National Jewish Health-Northern Hematology Oncology
      • Wheat Ridge, Colorado, Forenede Stater, 80033
        • SCL Health Lutheran Medical Center
    • Florida
      • Jacksonville, Florida, Forenede Stater, 32224-9980
        • Mayo Clinic in Florida
    • Georgia
      • Albany, Georgia, Forenede Stater, 31701
        • Phoebe Putney Memorial Hospital
      • Athens, Georgia, Forenede Stater, 30607
        • University Cancer and Blood Center LLC
      • Augusta, Georgia, Forenede Stater, 30912
        • Augusta University Medical Center
      • Decatur, Georgia, Forenede Stater, 30033
        • Dekalb Medical Center
      • Savannah, Georgia, Forenede Stater, 31405
        • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
      • Savannah, Georgia, Forenede Stater, 31405
        • Low Country Cancer Care Associates PC
      • Savannah, Georgia, Forenede Stater, 31405
        • Summit Cancer Care-Candler
    • Hawaii
      • Honolulu, Hawaii, Forenede Stater, 96819
        • Kaiser Permanente Moanalua Medical Center
    • Illinois
      • Bloomington, Illinois, Forenede Stater, 61704
        • Illinois CancerCare-Bloomington
      • Canton, Illinois, Forenede Stater, 61520
        • Illinois CancerCare-Canton
      • Carbondale, Illinois, Forenede Stater, 62902
        • Memorial Hospital of Carbondale
      • Carterville, Illinois, Forenede Stater, 62918
        • SIH Cancer Institute
      • Carthage, Illinois, Forenede Stater, 62321
        • Illinois CancerCare-Carthage
      • Centralia, Illinois, Forenede Stater, 62801
        • Centralia Oncology Clinic
      • Chicago, Illinois, Forenede Stater, 60611
        • Northwestern University
      • Chicago, Illinois, Forenede Stater, 60612
        • John H Stroger Jr Hospital of Cook County
      • Decatur, Illinois, Forenede Stater, 62526
        • Decatur Memorial Hospital
      • Decatur, Illinois, Forenede Stater, 62526
        • Cancer Care Specialists of Illinois - Decatur
      • Dixon, Illinois, Forenede Stater, 61021
        • Illinois CancerCare-Dixon
      • Effingham, Illinois, Forenede Stater, 62401
        • Crossroads Cancer Center
      • Eureka, Illinois, Forenede Stater, 61530
        • Illinois CancerCare-Eureka
      • Galesburg, Illinois, Forenede Stater, 61401
        • Western Illinois Cancer Treatment Center
      • Galesburg, Illinois, Forenede Stater, 61401
        • Illinois CancerCare-Galesburg
      • Kewanee, Illinois, Forenede Stater, 61443
        • Illinois CancerCare-Kewanee Clinic
      • Macomb, Illinois, Forenede Stater, 61455
        • Illinois CancerCare-Macomb
      • O'Fallon, Illinois, Forenede Stater, 62269
        • Cancer Care Center of O'Fallon
      • Ottawa, Illinois, Forenede Stater, 61350
        • Illinois CancerCare-Ottawa Clinic
      • Pekin, Illinois, Forenede Stater, 61554
        • Illinois CancerCare-Pekin
      • Pekin, Illinois, Forenede Stater, 61554
        • OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
      • Peoria, Illinois, Forenede Stater, 61636
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, Forenede Stater, 61637
        • OSF Saint Francis Medical Center
      • Peoria, Illinois, Forenede Stater, 61615
        • Illinois CancerCare-Peoria
      • Peoria, Illinois, Forenede Stater, 61615
        • OSF Saint Francis Radiation Oncology at Peoria Cancer Center
      • Peru, Illinois, Forenede Stater, 61354
        • Illinois CancerCare-Peru
      • Peru, Illinois, Forenede Stater, 61354
        • Valley Radiation Oncology
      • Princeton, Illinois, Forenede Stater, 61356
        • Illinois CancerCare-Princeton
      • Springfield, Illinois, Forenede Stater, 62781
        • Memorial Medical Center
      • Springfield, Illinois, Forenede Stater, 62702
        • Southern Illinois University School of Medicine
      • Springfield, Illinois, Forenede Stater, 62702
        • Springfield Clinic
      • Swansea, Illinois, Forenede Stater, 62226
        • Southwest Illinois Health Services LLP
    • Iowa
      • Ames, Iowa, Forenede Stater, 50010
        • McFarland Clinic PC - Ames
      • Ames, Iowa, Forenede Stater, 50010
        • Mary Greeley Medical Center
      • Boone, Iowa, Forenede Stater, 50036
        • McFarland Clinic PC-Boone
      • Fort Dodge, Iowa, Forenede Stater, 50501
        • McFarland Clinic PC-Trinity Cancer Center
      • Jefferson, Iowa, Forenede Stater, 50129
        • McFarland Clinic PC-Jefferson
      • Marshalltown, Iowa, Forenede Stater, 50158
        • McFarland Clinic PC-Marshalltown
      • Sioux City, Iowa, Forenede Stater, 51101
        • Siouxland Regional Cancer Center
    • Kansas
      • Chanute, Kansas, Forenede Stater, 66720
        • Cancer Center of Kansas - Chanute
      • Dodge City, Kansas, Forenede Stater, 67801
        • Cancer Center of Kansas - Dodge City
      • El Dorado, Kansas, Forenede Stater, 67042
        • Cancer Center of Kansas - El Dorado
      • Fort Scott, Kansas, Forenede Stater, 66701
        • Cancer Center of Kansas - Fort Scott
      • Garden City, Kansas, Forenede Stater, 67846
        • Central Care Cancer Center - Garden City
      • Great Bend, Kansas, Forenede Stater, 67530
        • Central Care Cancer Center - Great Bend
      • Independence, Kansas, Forenede Stater, 67301
        • Cancer Center of Kansas-Independence
      • Kingman, Kansas, Forenede Stater, 67068
        • Cancer Center of Kansas-Kingman
      • Lawrence, Kansas, Forenede Stater, 66044
        • Lawrence Memorial Hospital
      • Lenexa, Kansas, Forenede Stater, 66219
        • Kansas Institute of Medicine Cancer and Blood Center
      • Lenexa, Kansas, Forenede Stater, 66219
        • Minimally Invasive Surgery Hospital
      • Liberal, Kansas, Forenede Stater, 67905
        • Cancer Center of Kansas-Liberal
      • Manhattan, Kansas, Forenede Stater, 66502
        • Cancer Center of Kansas-Manhattan
      • McPherson, Kansas, Forenede Stater, 67460
        • Cancer Center of Kansas - McPherson
      • Newton, Kansas, Forenede Stater, 67114
        • Cancer Center of Kansas - Newton
      • Overland Park, Kansas, Forenede Stater, 66209
        • Menorah Medical Center
      • Parsons, Kansas, Forenede Stater, 67357
        • Cancer Center of Kansas - Parsons
      • Pratt, Kansas, Forenede Stater, 67124
        • Cancer Center of Kansas - Pratt
      • Salina, Kansas, Forenede Stater, 67401
        • Cancer Center of Kansas - Salina
      • Wellington, Kansas, Forenede Stater, 67152
        • Cancer Center of Kansas - Wellington
      • Wichita, Kansas, Forenede Stater, 67214
        • Ascension Via Christi Hospitals Wichita
      • Wichita, Kansas, Forenede Stater, 67208
        • Cancer Center of Kansas-Wichita Medical Arts Tower
      • Wichita, Kansas, Forenede Stater, 67214
        • Cancer Center of Kansas - Wichita
      • Wichita, Kansas, Forenede Stater, 67208
        • Associates In Womens Health
      • Wichita, Kansas, Forenede Stater, 67214
        • Wesley Medical Center
      • Winfield, Kansas, Forenede Stater, 67156
        • Cancer Center of Kansas - Winfield
    • Louisiana
      • New Orleans, Louisiana, Forenede Stater, 70121
        • Ochsner Medical Center Jefferson
    • Minnesota
      • Aitkin, Minnesota, Forenede Stater, 56431
        • Riverwood Healthcare Center
      • Bemidji, Minnesota, Forenede Stater, 56601
        • Sanford Joe Lueken Cancer Center
      • Brainerd, Minnesota, Forenede Stater, 56401
        • Essentia Health Saint Joseph's Medical Center
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Fairview Ridges Hospital
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Minnesota Oncology - Burnsville
      • Cambridge, Minnesota, Forenede Stater, 55008
        • Cambridge Medical Center
      • Coon Rapids, Minnesota, Forenede Stater, 55433
        • Mercy Hospital
      • Deer River, Minnesota, Forenede Stater, 56636
        • Essentia Health - Deer River Clinic
      • Detroit Lakes, Minnesota, Forenede Stater, 56501
        • Essentia Health Saint Mary's - Detroit Lakes Clinic
      • Duluth, Minnesota, Forenede Stater, 55805
        • Essentia Health Cancer Center
      • Duluth, Minnesota, Forenede Stater, 55805
        • Essentia Health Saint Mary's Medical Center
      • Duluth, Minnesota, Forenede Stater, 55805
        • Miller-Dwan Hospital
      • Edina, Minnesota, Forenede Stater, 55435
        • Fairview Southdale Hospital
      • Fergus Falls, Minnesota, Forenede Stater, 56537
        • Lake Region Healthcare Corporation-Cancer Care
      • Fosston, Minnesota, Forenede Stater, 56542
        • Essentia Health - Fosston
      • Fridley, Minnesota, Forenede Stater, 55432
        • Unity Hospital
      • Hibbing, Minnesota, Forenede Stater, 55746
        • Essentia Health Hibbing Clinic
      • Maple Grove, Minnesota, Forenede Stater, 55369
        • Fairview Clinics and Surgery Center Maple Grove
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Saint John's Hospital - Healtheast
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Minnesota Oncology Hematology PA-Maplewood
      • Minneapolis, Minnesota, Forenede Stater, 55415
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Abbott-Northwestern Hospital
      • Minneapolis, Minnesota, Forenede Stater, 55454
        • Health Partners Inc
      • Monticello, Minnesota, Forenede Stater, 55362
        • Monticello Cancer Center
      • New Ulm, Minnesota, Forenede Stater, 56073
        • New Ulm Medical Center
      • Park Rapids, Minnesota, Forenede Stater, 56470
        • Essentia Health - Park Rapids
      • Princeton, Minnesota, Forenede Stater, 55371
        • Fairview Northland Medical Center
      • Robbinsdale, Minnesota, Forenede Stater, 55422
        • North Memorial Medical Health Center
      • Rochester, Minnesota, Forenede Stater, 55905
        • Mayo Clinic in Rochester
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Paul, Minnesota, Forenede Stater, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • United Hospital
      • Sandstone, Minnesota, Forenede Stater, 55072
        • Essentia Health Sandstone
      • Shakopee, Minnesota, Forenede Stater, 55379
        • Saint Francis Regional Medical Center
      • Stillwater, Minnesota, Forenede Stater, 55082
        • Lakeview Hospital
      • Thief River Falls, Minnesota, Forenede Stater, 56701
        • Sanford Thief River Falls Medical Center
      • Virginia, Minnesota, Forenede Stater, 55792
        • Essentia Health Virginia Clinic
      • Waconia, Minnesota, Forenede Stater, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, Forenede Stater, 56201
        • Rice Memorial Hospital
      • Woodbury, Minnesota, Forenede Stater, 55125
        • Minnesota Oncology Hematology PA-Woodbury
      • Worthington, Minnesota, Forenede Stater, 56187
        • Sanford Cancer Center Worthington
      • Wyoming, Minnesota, Forenede Stater, 55092
        • Fairview Lakes Medical Center
    • Missouri
      • Bolivar, Missouri, Forenede Stater, 65613
        • Central Care Cancer Center - Bolivar
      • Bonne Terre, Missouri, Forenede Stater, 63628
        • Parkland Health Center-Bonne Terre
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Saint Francis Medical Center
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Southeast Cancer Center
      • Farmington, Missouri, Forenede Stater, 63640
        • Parkland Health Center - Farmington
      • Independence, Missouri, Forenede Stater, 64057
        • Centerpoint Medical Center LLC
      • Jefferson City, Missouri, Forenede Stater, 65109
        • Capital Region Southwest Campus
      • Kansas City, Missouri, Forenede Stater, 64132
        • Research Medical Center
      • Sainte Genevieve, Missouri, Forenede Stater, 63670
        • Sainte Genevieve County Memorial Hospital
      • St Louis, Missouri, Forenede Stater, 63131
        • Missouri Baptist Medical Center
      • Sullivan, Missouri, Forenede Stater, 63080
        • Missouri Baptist Sullivan Hospital
      • Sunset Hills, Missouri, Forenede Stater, 63127
        • Missouri Baptist Outpatient Center-Sunset Hills
    • Montana
      • Billings, Montana, Forenede Stater, 59101
        • Saint Vincent Healthcare
      • Billings, Montana, Forenede Stater, 59102
        • Saint Vincent Frontier Cancer Center
      • Butte, Montana, Forenede Stater, 59701
        • Saint James Community Hospital and Cancer Treatment Center
    • New York
      • New York, New York, Forenede Stater, 10065
        • Memorial Sloan Kettering Cancer Center
    • North Carolina
      • Asheville, North Carolina, Forenede Stater, 28803
        • AdventHealth Infusion Center Asheville
      • Clyde, North Carolina, Forenede Stater, 28721
        • AdventHealth Infusion Center Haywood
      • Hendersonville, North Carolina, Forenede Stater, 28792
        • AdventHealth Hendersonville
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Sanford Bismarck Medical Center
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Roger Maris Cancer Center
      • Fargo, North Dakota, Forenede Stater, 58103
        • Essentia Health Cancer Center-South University Clinic
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Broadway Medical Center
      • Fargo, North Dakota, Forenede Stater, 58103
        • Sanford South University Medical Center
      • Jamestown, North Dakota, Forenede Stater, 58401
        • Essentia Health - Jamestown Clinic
    • Pennsylvania
      • Bryn Mawr, Pennsylvania, Forenede Stater, 19010
        • Bryn Mawr Hospital
      • Collegeville, Pennsylvania, Forenede Stater, 19426
        • Main Line Health Center-Collegeville
      • Danville, Pennsylvania, Forenede Stater, 17822
        • Geisinger Medical Center
      • Exton, Pennsylvania, Forenede Stater, 19341
        • Main Line Health Center-Exton
      • Media, Pennsylvania, Forenede Stater, 19063
        • Riddle Memorial Hospital
      • Paoli, Pennsylvania, Forenede Stater, 19301
        • Paoli Memorial Hospital
      • Philadelphia, Pennsylvania, Forenede Stater, 19104
        • University of Pennsylvania/Abramson Cancer Center
      • Wynnewood, Pennsylvania, Forenede Stater, 19096
        • Lankenau Medical Center
    • South Carolina
      • Gaffney, South Carolina, Forenede Stater, 29341
        • Gibbs Cancer Center-Gaffney
      • Greenville, South Carolina, Forenede Stater, 29607
        • Saint Francis Cancer Center
      • Greenville, South Carolina, Forenede Stater, 29601
        • Saint Francis Hospital
      • Greer, South Carolina, Forenede Stater, 29651
        • Gibbs Cancer Center-Pelham
      • Spartanburg, South Carolina, Forenede Stater, 29303
        • Spartanburg Medical Center
      • Union, South Carolina, Forenede Stater, 29379
        • MGC Hematology Oncology-Union
    • South Dakota
      • Sioux Falls, South Dakota, Forenede Stater, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
      • Sioux Falls, South Dakota, Forenede Stater, 57104
        • Sanford Cancer Center Oncology Clinic
    • Tennessee
      • Memphis, Tennessee, Forenede Stater, 38120
        • Baptist Memorial Hospital and Cancer Center-Memphis
    • Utah
      • American Fork, Utah, Forenede Stater, 84003
        • American Fork Hospital / Huntsman Intermountain Cancer Center
      • Cedar City, Utah, Forenede Stater, 84720
        • Sandra L Maxwell Cancer Center
      • Logan, Utah, Forenede Stater, 84321
        • Logan Regional Hospital
      • Murray, Utah, Forenede Stater, 84107
        • Intermountain Medical Center
      • Ogden, Utah, Forenede Stater, 84403
        • McKay-Dee Hospital Center
      • Provo, Utah, Forenede Stater, 84604
        • Utah Valley Regional Medical Center
      • Riverton, Utah, Forenede Stater, 84065
        • Riverton Hospital
      • Salt Lake City, Utah, Forenede Stater, 84106
        • Utah Cancer Specialists-Salt Lake City
      • Salt Lake City, Utah, Forenede Stater, 84143
        • LDS Hospital
      • St. George, Utah, Forenede Stater, 84770
        • Dixie Medical Center Regional Cancer Center
    • Washington
      • Auburn, Washington, Forenede Stater, 98001
        • MultiCare Auburn Medical Center
      • Gig Harbor, Washington, Forenede Stater, 98335
        • MultiCare Gig Harbor Medical Park
      • Port Townsend, Washington, Forenede Stater, 98368
        • Jefferson Healthcare
      • Puyallup, Washington, Forenede Stater, 98372
        • MultiCare Good Samaritan Hospital
      • Spokane, Washington, Forenede Stater, 99204
        • MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
      • Spokane, Washington, Forenede Stater, 99218
        • MultiCare Deaconess Cancer and Blood Specialty Center - North
      • Spokane Valley, Washington, Forenede Stater, 99216
        • MultiCare Deaconess Cancer and Blood Specialty Center - Valley
      • Tacoma, Washington, Forenede Stater, 98405
        • Mary Bridge Children's Hospital and Health Center
      • Tacoma, Washington, Forenede Stater, 98405
        • MultiCare Tacoma General Hospital
    • Wisconsin
      • Appleton, Wisconsin, Forenede Stater, 54911
        • ThedaCare Regional Cancer Center
      • Ashland, Wisconsin, Forenede Stater, 54806
        • Duluth Clinic Ashland
      • Ashland, Wisconsin, Forenede Stater, 54806
        • Northwest Wisconsin Cancer Center
      • Burlington, Wisconsin, Forenede Stater, 53105
        • Aurora Cancer Care-Southern Lakes VLCC
      • Cudahy, Wisconsin, Forenede Stater, 53110
        • Aurora Saint Luke's South Shore
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Marshfield Medical Center-EC Cancer Center
      • Fond du Lac, Wisconsin, Forenede Stater, 54937
        • Aurora Health Center-Fond du Lac
      • Germantown, Wisconsin, Forenede Stater, 53022
        • Aurora Health Care Germantown Health Center
      • Grafton, Wisconsin, Forenede Stater, 53024
        • Aurora Cancer Care-Grafton
      • Green Bay, Wisconsin, Forenede Stater, 54311
        • Aurora BayCare Medical Center
      • Kenosha, Wisconsin, Forenede Stater, 53142
        • Aurora Cancer Care-Kenosha South
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Gundersen Lutheran Medical Center
      • Marinette, Wisconsin, Forenede Stater, 54143
        • Aurora Bay Area Medical Group-Marinette
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Marshfield Medical Center-Marshfield
      • Milwaukee, Wisconsin, Forenede Stater, 53209
        • Aurora Cancer Care-Milwaukee
      • Milwaukee, Wisconsin, Forenede Stater, 53215
        • Aurora Saint Luke's Medical Center
      • Milwaukee, Wisconsin, Forenede Stater, 53233
        • Aurora Sinai Medical Center
      • Minocqua, Wisconsin, Forenede Stater, 54548
        • Marshfield Clinic-Minocqua Center
      • New Richmond, Wisconsin, Forenede Stater, 54017
        • Cancer Center of Western Wisconsin
      • Oshkosh, Wisconsin, Forenede Stater, 54904
        • Vince Lombardi Cancer Clinic - Oshkosh
      • Racine, Wisconsin, Forenede Stater, 53406
        • Aurora Cancer Care-Racine
      • Rice Lake, Wisconsin, Forenede Stater, 54868
        • Marshfield Medical Center-Rice Lake
      • Rice Lake, Wisconsin, Forenede Stater, 54868
        • Lakeview Medical Center-Marshfield Clinic
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • Vince Lombardi Cancer Clinic-Sheboygan
      • Stevens Point, Wisconsin, Forenede Stater, 54482
        • Marshfield Clinic Stevens Point Center
      • Summit, Wisconsin, Forenede Stater, 53066
        • Aurora Medical Center in Summit
      • Two Rivers, Wisconsin, Forenede Stater, 54241
        • Vince Lombardi Cancer Clinic-Two Rivers
      • Wauwatosa, Wisconsin, Forenede Stater, 53226
        • Aurora Cancer Care-Milwaukee West
      • West Allis, Wisconsin, Forenede Stater, 53227
        • Aurora West Allis Medical Center
      • Weston, Wisconsin, Forenede Stater, 54476
        • Marshfield Medical Center - Weston
    • Wyoming
      • Cheyenne, Wyoming, Forenede Stater, 82001
        • Cheyenne Regional Medical Center-West
  • Puerto Rico
      • Aguadilla, Puerto Rico, 00603
        • Advance Oncology Center
      • Arecibo, Puerto Rico, 00614
        • Doctor's Cancer Center-Arecibo
      • Bayamón, Puerto Rico, 00959-5060
        • Cancer Center-Metro Medical Center Bayamon
      • Bayamón, Puerto Rico, 00961
        • Hematologia Oncologia San Pablo
      • Caguas, Puerto Rico, 00726
        • HIMA San Pablo Oncologic Hospital
      • Manati, Puerto Rico, 00674
        • Doctors Cancer Center
      • Ponce, Puerto Rico, 00716
        • Instituto Oncologia Moderna Ponce
      • San Juan, Puerto Rico, 00917
        • San Juan Community Oncology Group
      • San Juan, Puerto Rico, 00927
        • Centro Comprensivo de Cancer de UPR
      • San Juan, Puerto Rico, 00936
        • San Juan City Hospital
      • San Juan, Puerto Rico, 00920
        • Primary Care Physician Group
      • Santa Isabel, Puerto Rico, 00757
        • Centro de Hematologia y Oncologia del Sur

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Studiebefolkning

Patienter med bekræftet APL 18 år og derover.

Beskrivelse

Inklusionskriterier:

  • Bekræftet at have en diagnose APL, som er defineret som:

    • Positiv t(15:17) ved fluorescens in situ hybridisering (FISH) eller konventionel karyotype
    • Positiv promyelocytisk leukæmi/retinsyrereceptor PML/RAR alfa ved polymerasekædereaktion (PCR)
  • Patienter skal acceptere retningslinjer for behandling og støttende pleje
  • Henvisninger skal ske så tidligt som muligt, men senest 5 kalenderdage efter, at ATRA-behandling er påbegyndt; samtykke kan indhentes indtil dag 7 eller tidligere
  • Co-management kan påbegyndes så snart henvisning er foretaget inklusive weekender; lægen på den yderliggende facilitet bør gøre alt for at ringe til APL-eksperten ved den første mistanke om APL

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Andet
  • Tildeling: N/A
  • Interventionel model: Enkelt gruppeopgave
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: Forenklet patientplejestrategi plus APL -ekspertstøtte
Patienter får standard for plejebehandling for APL. Behandling af læger diskuterer regelmæssigt med en APL -ekspert for at identificere og vekke behandling.
Andet: Laboratoriebiomarkøranalyse
Korrelative undersøgelser
Andet: Forenklet patientplejestrategi
Behandling pr. Akut promyelocytisk leukæmi (APL) behandlingsretningslinjer plus diskussion mellem læger og APL -ekspert

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
En måneders dødelighed
Tidsramme: Vurderet efter en måned
Andelen af ​​patienter døde inden for en måned fra den første dato for induktionsterapi.
Vurderet efter en måned

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Overlevelsesrate på et år
Tidsramme: Vurderet på et år
Den samlede overlevelse defineres som tiden fra den første dato for induktionsterapi til død eller dato sidst kendt levende. Andelen af ​​patienter, der var i live på et år, blev estimeret ved anvendelse af metoden i forhold til Kaplan og Meier.
Vurderet på et år
En-måneders overlevelsesrate af hovedakademiske steder og samfundssteder
Tidsramme: Vurderet efter en måned
Andel af patienter, der er i live på en måned siden den første dato for induktionsterapi af hovedakademiske steder og samfundssteder
Vurderet efter en måned
Differentieringssyndrom
Tidsramme: Vurderet op til 1 år
Andelen af ​​patienter med differentieringssyndrom (målt baseret på CTC version 4.0) evalueres.
Vurderet op til 1 år
Forbindelse mellem en måneders dødelighed og tid fra diagnose til påbegyndelse af retinsyre med all-trans retinsyre (ATRA)
Tidsramme: Vurderet efter en måned
Tiden fra diagnose og initiering af ATRA vurderes og dikotomiseres som "kort 'vs." lang "ved hjælp af medianværdien. En måneders dødelighed sammenlignes i disse to grupper (kort vs. lang) ved hjælp af Fishers nøjagtige test.
Vurderet efter en måned
Forbindelse mellem en måneders overlevelse og baselinefaktorer
Tidsramme: Vurderet ved baseline og en måned
Forbindelserne mellem overlevelse på en måned og baseline-faktorer vil blive evalueret.
Vurderet ved baseline og en måned

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

ECOG-ACRIN Cancer Research Group

Samarbejdspartnere

National Cancer Institute (NCI)

Efterforskere

  • Ledende efterforsker: Anand Jillella, ECOG-ACRIN Cancer Research Group

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

26. september 2017

Primær færdiggørelse (Faktiske)

27. april 2023

Studieafslutning (Anslået)

31. december 2027

Datoer for studieregistrering

Først indsendt

16. august 2017

Først indsendt, der opfyldte QC-kriterier

16. august 2017

Først opslået (Faktiske)

18. august 2017

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

29. maj 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

12. maj 2026

Sidst verificeret

1. maj 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • EA9131 (Anden identifikator: CTEP)
  • UG1CA189828 (U.S. NIH-bevilling/kontrakt)
  • NCI-2016-01123 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
  • U10CA037403 (U.S. NIH-bevilling/kontrakt)

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

JA

IPD-planbeskrivelse

Individuelle deltagerdata kan stilles til rådighed efter anmodning i henhold til ECOG-acrin-datadelingspolitikken.

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ingen

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Laboratoriebiomarkøranalyse

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Spain

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

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