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Olanzapin med eller uden Fosaprepitant Dimeglumine til forebyggelse af kemoterapi-induceret kvalme og opkastning hos kræftpatienter, der modtager stærkt emetogen kemoterapi

4. maj 2023 opdateret af: Alliance for Clinical Trials in Oncology

Olanzapin med eller uden fosaprepitant til forebyggelse af kemoterapi-induceret kvalme og opkastning (CINV) hos patienter, der modtager stærkt emetogen kemoterapi (HEC): Et fase III randomiseret, dobbeltblindt, placebokontrolleret forsøg

Dette randomiserede fase III-studie undersøger, hvor godt olanzapin med eller uden fosaprepitant virker til at forebygge kemoterapi-induceret kvalme og opkastning hos cancerpatienter, der får kemoterapi, der forårsager opkastning. Olanzapin og fosaprepitant dimeglumin kan hjælpe med at kontrollere kvalme og opkastning hos patienter under kemoterapi. Olanzapin gives normalt i kombination med andre lægemidler, herunder fosaprepitant dimeglumin. Det vides endnu ikke, om olanzapin, når det gives sammen med andre lægemidler, stadig er effektivt uden brug af fosaprepitant dimeglumin til at kontrollere kvalme og opkastning.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆRE MÅL:

I. For at sammenligne mellem de to undersøgelsesarme andelen af ​​patienter uden kvalme i den samlede (0-120 timer efter kemoterapi), akutte (0-24 timer efter kemoterapi) og forsinkede perioder (24-120 timer efter kemoterapi). kemoterapi) til patienter, der modtager højemetogen kemoterapi (HEC).

SEKUNDÆRE MÅL:

I. For at sammenligne mellem de to undersøgelsesarme den fuldstændige respons (CR) rater (ingen emetiske episoder og ingen brug af redningsmedicin) i de akutte, forsinkede og overordnede perioder.

II. For at sammenligne mellem de to undersøgelsesarme, forekomsten af ​​potentielle toksiciteter, der er blevet tilskrevet olanzapin.

III. At udføre en økonomisk evaluering af olanzapin og fosaprepitant dimeglumin (fosaprepitant) versus (vs.) olanzapin hos patienter, der får HEC (bemærk, at alle patienter også vil modtage dexamethason og en 5HT3-receptorantagonist).

IV. At udforske effektiviteten af ​​olanzapin i kemoterapicyklusser to til fire, for patienter, der vælger at fortsætte på det samme antiemetiske regime modtaget i cyklus et, i kemoterapicyklusser to til fire (fortsættelsesfase), ved at dokumentere kvalme og fuldstændig respons.

V. At udforske sikkerheden af ​​olanzapin i kemoterapicyklusser to til fire, for patienter, der vælger at fortsætte på det samme antiemetiske regime modtaget i cyklus et, i kemoterapicyklusser to til fire (fortsættelsesfase), ved at registrere eventuelle bivirkninger eller lægemiddelrelaterede toksiciteter.

OVERSIGT: Patienterne randomiseres til 1 af 2 arme.

ARM I: Patienterne får palonosetronhydrochlorid intravenøst ​​(IV) over 30 sekunder eller ondansetronhydrochlorid IV over 2-5 minutter eller oralt (PO) på dag 1, dexamethason PO på dag 1-4, fosaprepitant dimeglumin IV over 20-30 minutter på dagen 1, og olanzapin PO på dag 1-4. Behandlingen kan gentages hver 4. dag i op til 3 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.

ARM II: Patienter får palonosetronhydrochlorid IV over 30 sekunder eller ondansetronhydrochlorid IV over 2-5 minutter eller PO på dag 1, dexamethason PO på dag 1-4, placebo IV over 20-30 minutter på dag 1 og olanzapin PO på dage 1-4. Behandling (uden placebo) kan gentages hver 4. dag i op til 3 kure i fravær af sygdomsprogression eller uacceptabel toksicitet.

Efter afslutning af undersøgelsen følges patienterne periodisk op.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

690

Fase

  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Forenede Stater
    • Alabama
      • Birmingham, Alabama, Forenede Stater, 35233
        • University of Alabama at Birmingham Cancer Center
    • Alaska
      • Fairbanks, Alaska, Forenede Stater, 99701
        • Fairbanks Memorial Hospital
    • Arizona
      • Kingman, Arizona, Forenede Stater, 86401
        • Kingman Regional Medical Center
      • Phoenix, Arizona, Forenede Stater, 85054
        • Mayo Clinic Hospital in Arizona
      • Scottsdale, Arizona, Forenede Stater, 85259
        • Mayo Clinic in Arizona
    • Arkansas
      • Fort Smith, Arkansas, Forenede Stater, 72903
        • Mercy Hospital Fort Smith
      • Jonesboro, Arkansas, Forenede Stater, 72401
        • Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
    • California
      • Arroyo Grande, California, Forenede Stater, 93420
        • PCR Oncology
      • Dublin, California, Forenede Stater, 94568
        • Epic Care-Dublin
      • Emeryville, California, Forenede Stater, 94608
        • Bay Area Breast Surgeons Inc
      • Emeryville, California, Forenede Stater, 94608
        • Epic Care Partners in Cancer Care
      • Long Beach, California, Forenede Stater, 90822
        • Tibor Rubin VA Medical Center
      • Martinez, California, Forenede Stater, 94553-3156
        • Contra Costa Regional Medical Center
      • Oakland, California, Forenede Stater, 94609
        • Alta Bates Summit Medical Center - Summit Campus
      • Oakland, California, Forenede Stater, 94609
        • Bay Area Tumor Institute
      • Palm Springs, California, Forenede Stater, 92262
        • Desert Regional Medical Center
      • Walnut Creek, California, Forenede Stater, 94597
        • Epic Care Cyberknife Center
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80012
        • Rocky Mountain Cancer Centers-Aurora
      • Aurora, Colorado, Forenede Stater, 80012
        • The Medical Center of Aurora
      • Boulder, Colorado, Forenede Stater, 80301
        • Boulder Community Hospital
      • Boulder, Colorado, Forenede Stater, 80303
        • Boulder Community Foothills Hospital
      • Boulder, Colorado, Forenede Stater, 80304
        • Rocky Mountain Cancer Centers-Boulder
      • Centennial, Colorado, Forenede Stater, 80112
        • Rocky Mountain Cancer Centers - Centennial
      • Denver, Colorado, Forenede Stater, 80218
        • Presbyterian - Saint Lukes Medical Center - Health One
      • Denver, Colorado, Forenede Stater, 80218
        • SCL Health Saint Joseph Hospital
      • Denver, Colorado, Forenede Stater, 80220
        • Rose Medical Center
      • Denver, Colorado, Forenede Stater, 80218
        • Rocky Mountain Cancer Centers-Midtown
      • Denver, Colorado, Forenede Stater, 80220
        • Rocky Mountain Cancer Centers-Rose
      • Denver, Colorado, Forenede Stater, 80204
        • Denver Health Medical Center
      • Denver, Colorado, Forenede Stater, 80218
        • Colorado Blood Cancer Institute
      • Denver, Colorado, Forenede Stater, 80204
        • Cancer Center of Colorado at Sloan's Lake
      • Denver, Colorado, Forenede Stater, 80209
        • The Women's Imaging Center
      • Denver, Colorado, Forenede Stater, 80206
        • National Jewish Health-Main Campus
      • Denver, Colorado, Forenede Stater, 80220
        • Western Surgical Care
      • Englewood, Colorado, Forenede Stater, 80113
        • Mountain Blue Cancer Care Center - Swedish
      • Englewood, Colorado, Forenede Stater, 80113
        • Swedish Medical Center
      • Golden, Colorado, Forenede Stater, 80401
        • National Jewish Health-Western Hematology Oncology
      • Grand Junction, Colorado, Forenede Stater, 81501
        • Saint Mary's Hospital and Regional Medical Center
      • Grand Junction, Colorado, Forenede Stater, 81505
        • Grand Valley Oncology
      • Greeley, Colorado, Forenede Stater, 80631
        • North Colorado Medical Center
      • Lafayette, Colorado, Forenede Stater, 80026
        • Good Samaritan Medical Center
      • Littleton, Colorado, Forenede Stater, 80120
        • Rocky Mountain Cancer Centers-Littleton
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Sky Ridge Medical Center
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Rocky Mountain Cancer Centers-Sky Ridge
      • Loveland, Colorado, Forenede Stater, 80539
        • McKee Medical Center
      • Thornton, Colorado, Forenede Stater, 80260
        • National Jewish Health-Northern Hematology Oncology
      • Wheat Ridge, Colorado, Forenede Stater, 80033
        • SCL Health Lutheran Medical Center
    • Connecticut
      • Middletown, Connecticut, Forenede Stater, 06457
        • Middlesex Hospital
    • Florida
      • Fort Lauderdale, Florida, Forenede Stater, 33308
        • Holy Cross Hospital
      • Jacksonville, Florida, Forenede Stater, 32224-9980
        • Mayo Clinic in Florida
    • Hawaii
      • 'Aiea, Hawaii, Forenede Stater, 96701
        • Hawaii Cancer Care - Savio
      • 'Aiea, Hawaii, Forenede Stater, 96701
        • Pali Momi Medical Center
      • 'Aiea, Hawaii, Forenede Stater, 96701
        • Queen's Cancer Center - Pearlridge
      • 'Aiea, Hawaii, Forenede Stater, 96701
        • The Cancer Center of Hawaii-Pali Momi
      • 'Ewa Beach, Hawaii, Forenede Stater, 96706
        • The Queen's Medical Center - West Oahu
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Queen's Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96817
        • The Cancer Center of Hawaii-Liliha
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Hawaii Cancer Care Inc - Waterfront Plaza
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Queen's Cancer Cenrer - POB I
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Straub Clinic and Hospital
      • Honolulu, Hawaii, Forenede Stater, 96813
        • University of Hawaii Cancer Center
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Hawaii Cancer Care Inc-Liliha
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Kuakini Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Queen's Cancer Center - Kuakini
      • Honolulu, Hawaii, Forenede Stater, 96826
        • Kapiolani Medical Center for Women and Children
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Island Urology
      • Honolulu, Hawaii, Forenede Stater, 96859
        • Tripler Army Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Hawaii Diagnostic Radiology Services LLC
      • Kahului, Hawaii, Forenede Stater, 96732
        • Straub Medical Center - Kahului Clinic
      • Kailua, Hawaii, Forenede Stater, 96734
        • Castle Medical Center
      • Lihue, Hawaii, Forenede Stater, 96766
        • Wilcox Memorial Hospital and Kauai Medical Clinic
    • Idaho
      • Boise, Idaho, Forenede Stater, 83706
        • Saint Alphonsus Cancer Care Center-Boise
      • Caldwell, Idaho, Forenede Stater, 83605
        • Saint Alphonsus Cancer Care Center-Caldwell
      • Coeur d'Alene, Idaho, Forenede Stater, 83814
        • Kootenai Health - Coeur d'Alene
      • Emmett, Idaho, Forenede Stater, 83617
        • Walter Knox Memorial Hospital
      • Meridian, Idaho, Forenede Stater, 83642
        • Idaho Urologic Institute-Meridian
      • Nampa, Idaho, Forenede Stater, 83686
        • Saint Alphonsus Medical Center-Nampa
      • Post Falls, Idaho, Forenede Stater, 83854
        • Kootenai Clinic Cancer Services - Post Falls
      • Sandpoint, Idaho, Forenede Stater, 83864
        • Kootenai Cancer Clinic
    • Illinois
      • Alton, Illinois, Forenede Stater, 62002
        • Saint Anthony's Health
      • Bloomington, Illinois, Forenede Stater, 61704
        • Illinois CancerCare-Bloomington
      • Burr Ridge, Illinois, Forenede Stater, 60527
        • Loyola Center for Health at Burr Ridge
      • Canton, Illinois, Forenede Stater, 61520
        • Illinois CancerCare-Canton
      • Carbondale, Illinois, Forenede Stater, 62902
        • Memorial Hospital of Carbondale
      • Carterville, Illinois, Forenede Stater, 62918
        • SIH Cancer Institute
      • Carthage, Illinois, Forenede Stater, 62321
        • Illinois CancerCare-Carthage
      • Centralia, Illinois, Forenede Stater, 62801
        • Centralia Oncology Clinic
      • Danville, Illinois, Forenede Stater, 61832
        • Carle on Vermilion
      • DeKalb, Illinois, Forenede Stater, 60115
        • Northwestern Medicine Cancer Center Kishwaukee
      • Decatur, Illinois, Forenede Stater, 62526
        • Decatur Memorial Hospital
      • Decatur, Illinois, Forenede Stater, 62526
        • Cancer Care Specialists of Illinois - Decatur
      • Dixon, Illinois, Forenede Stater, 61021
        • Illinois CancerCare-Dixon
      • Effingham, Illinois, Forenede Stater, 62401
        • Crossroads Cancer Center
      • Effingham, Illinois, Forenede Stater, 62401
        • Carle Physician Group-Effingham
      • Eureka, Illinois, Forenede Stater, 61530
        • Illinois CancerCare-Eureka
      • Evanston, Illinois, Forenede Stater, 60201
        • NorthShore University HealthSystem-Evanston Hospital
      • Galesburg, Illinois, Forenede Stater, 61401
        • Western Illinois Cancer Treatment Center
      • Galesburg, Illinois, Forenede Stater, 61401
        • Illinois CancerCare-Galesburg
      • Geneva, Illinois, Forenede Stater, 60134
        • Northwestern Medicine Cancer Center Delnor
      • Glenview, Illinois, Forenede Stater, 60026
        • NorthShore University HealthSystem-Glenbrook Hospital
      • Highland Park, Illinois, Forenede Stater, 60035
        • NorthShore University HealthSystem-Highland Park Hospital
      • Homer Glen, Illinois, Forenede Stater, 60491
        • Loyola Medicine Homer Glen
      • Kewanee, Illinois, Forenede Stater, 61443
        • Illinois CancerCare-Kewanee Clinic
      • Macomb, Illinois, Forenede Stater, 61455
        • Illinois CancerCare-Macomb
      • Mattoon, Illinois, Forenede Stater, 61938
        • Carle Physician Group-Mattoon/Charleston
      • Maywood, Illinois, Forenede Stater, 60153
        • Loyola University Medical Center
      • Melrose Park, Illinois, Forenede Stater, 60160
        • Marjorie Weinberg Cancer Center at Loyola-Gottlieb
      • Mount Vernon, Illinois, Forenede Stater, 62864
        • Good Samaritan Regional Health Center
      • O'Fallon, Illinois, Forenede Stater, 62269
        • Cancer Care Center of O'Fallon
      • Ottawa, Illinois, Forenede Stater, 61350
        • Illinois CancerCare-Ottawa Clinic
      • Pekin, Illinois, Forenede Stater, 61554
        • Illinois CancerCare-Pekin
      • Peoria, Illinois, Forenede Stater, 61636
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, Forenede Stater, 61615
        • Illinois CancerCare-Peoria
      • Peru, Illinois, Forenede Stater, 61354
        • Illinois CancerCare-Peru
      • Peru, Illinois, Forenede Stater, 61354
        • Valley Radiation Oncology
      • Princeton, Illinois, Forenede Stater, 61356
        • Illinois CancerCare-Princeton
      • Rockford, Illinois, Forenede Stater, 61108
        • OSF Saint Anthony Medical Center
      • Springfield, Illinois, Forenede Stater, 62781
        • Memorial Medical Center
      • Springfield, Illinois, Forenede Stater, 62702
        • Southern Illinois University School of Medicine
      • Springfield, Illinois, Forenede Stater, 62702
        • Springfield Clinic
      • Swansea, Illinois, Forenede Stater, 62226
        • Southwest Illinois Health Services LLP
      • Urbana, Illinois, Forenede Stater, 61801
        • Carle Cancer Center
      • Urbana, Illinois, Forenede Stater, 61801
        • The Carle Foundation Hospital
      • Warrenville, Illinois, Forenede Stater, 60555
        • Northwestern Medicine Cancer Center Warrenville
      • Washington, Illinois, Forenede Stater, 61571
        • Illinois CancerCare - Washington
    • Indiana
      • Anderson, Indiana, Forenede Stater, 46016
        • Saint Vincent Anderson Regional Hospital/Cancer Center
      • Mishawaka, Indiana, Forenede Stater, 46545
        • Memorial Regional Cancer Center Day Road
      • New Albany, Indiana, Forenede Stater, 47150
        • Baptist Health Floyd
      • Richmond, Indiana, Forenede Stater, 47374
        • Reid Health
      • South Bend, Indiana, Forenede Stater, 46601
        • Memorial Hospital of South Bend
    • Iowa
      • Ames, Iowa, Forenede Stater, 50010
        • McFarland Clinic PC - Ames
      • Ames, Iowa, Forenede Stater, 50010
        • Mary Greeley Medical Center
      • Bettendorf, Iowa, Forenede Stater, 52722
        • University of Iowa Healthcare Cancer Services Quad Cities
      • Boone, Iowa, Forenede Stater, 50036
        • McFarland Clinic PC-Boone
      • Carroll, Iowa, Forenede Stater, 51401
        • Saint Anthony Regional Hospital
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Mercy Hospital
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Oncology Associates at Mercy Medical Center
      • Des Moines, Iowa, Forenede Stater, 50309
        • Iowa Methodist Medical Center
      • Des Moines, Iowa, Forenede Stater, 50309
        • Medical Oncology and Hematology Associates-Des Moines
      • Des Moines, Iowa, Forenede Stater, 50314
        • Broadlawns Medical Center
      • Des Moines, Iowa, Forenede Stater, 50316
        • Iowa Lutheran Hospital
      • Fairfield, Iowa, Forenede Stater, 52556
        • JCHC McCreery Cancer Center
      • Fort Dodge, Iowa, Forenede Stater, 50501
        • McFarland Clinic PC-Trinity Cancer Center
      • Fort Dodge, Iowa, Forenede Stater, 50501
        • Trinity Regional Medical Center
      • Iowa City, Iowa, Forenede Stater, 52242
        • University of Iowa/Holden Comprehensive Cancer Center
      • Jefferson, Iowa, Forenede Stater, 50129
        • McFarland Clinic PC-Jefferson
      • Marshalltown, Iowa, Forenede Stater, 50158
        • McFarland Clinic PC-Marshalltown
      • Ottumwa, Iowa, Forenede Stater, 52501
        • Ottumwa Regional Health Center
      • Waterloo, Iowa, Forenede Stater, 50702
        • MercyOne Waterloo Medical Center
      • West Des Moines, Iowa, Forenede Stater, 50266-7700
        • Methodist West Hospital
    • Kansas
      • Chanute, Kansas, Forenede Stater, 66720
        • Cancer Center of Kansas - Chanute
      • Dodge City, Kansas, Forenede Stater, 67801
        • Cancer Center of Kansas - Dodge City
      • Garden City, Kansas, Forenede Stater, 67846
        • Central Care Cancer Center - Garden City
      • Great Bend, Kansas, Forenede Stater, 67530
        • Central Care Cancer Center - Great Bend
      • Lawrence, Kansas, Forenede Stater, 66044
        • Lawrence Memorial Hospital
      • Lenexa, Kansas, Forenede Stater, 66219
        • Kansas Institute of Medicine Cancer and Blood Center
      • Lenexa, Kansas, Forenede Stater, 66219
        • Minimally Invasive Surgery Hospital
      • Liberal, Kansas, Forenede Stater, 67905
        • Cancer Center of Kansas-Liberal
      • Newton, Kansas, Forenede Stater, 67114
        • Cancer Center of Kansas - Newton
      • Overland Park, Kansas, Forenede Stater, 66209
        • Menorah Medical Center
      • Topeka, Kansas, Forenede Stater, 66606
        • Cotton O'Neil Cancer Center / Stormont Vail Health
      • Wichita, Kansas, Forenede Stater, 67214
        • Ascension Via Christi Hospitals Wichita
      • Wichita, Kansas, Forenede Stater, 67208
        • Cancer Center of Kansas-Wichita Medical Arts Tower
      • Wichita, Kansas, Forenede Stater, 67214
        • Cancer Center of Kansas - Wichita
      • Wichita, Kansas, Forenede Stater, 67208
        • Associates In Womens Health
    • Kentucky
      • Corbin, Kentucky, Forenede Stater, 40701
        • Baptist Health Corbin
      • Elizabethtown, Kentucky, Forenede Stater, 42701
        • Baptist Health Hardin
      • Lexington, Kentucky, Forenede Stater, 40503
        • Baptist Health Lexington
      • Louisville, Kentucky, Forenede Stater, 40207
        • Baptist Health Louisville
      • Madisonville, Kentucky, Forenede Stater, 42431
        • Baptist Health Madisonville/Merle Mahr Cancer Center
      • Morehead, Kentucky, Forenede Stater, 40351
        • Saint Claire Regional Medical Center
      • Owensboro, Kentucky, Forenede Stater, 42303
        • Owensboro Health Mitchell Memorial Cancer Center
      • Paducah, Kentucky, Forenede Stater, 42003
        • Baptist Health Paducah
    • Louisiana
      • Baton Rouge, Louisiana, Forenede Stater, 70805
        • LSU Health Baton Rouge-North Clinic
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Louisiana Hematology Oncology Associates LLC
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Mary Bird Perkins Cancer Center
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Our Lady of the Lake Physicians Group - Medical Oncology
      • Baton Rouge, Louisiana, Forenede Stater, 70816
        • Medical Center of Baton Rouge
      • Baton Rouge, Louisiana, Forenede Stater, 70836
        • Ochsner High Grove
      • Baton Rouge, Louisiana, Forenede Stater, 70817
        • Woman's Hospital
      • Baton Rouge, Louisiana, Forenede Stater, 70817
        • Our Lady of the Lake Medical Oncology
      • Baton Rouge, Louisiana, Forenede Stater, 70817
        • Louisiana Hematology Oncology Associates
      • Covington, Louisiana, Forenede Stater, 70433
        • Northshore Oncology Associates-Covington
      • Covington, Louisiana, Forenede Stater, 70433
        • Ochsner Hematology Oncology North Shore - Covington (West Region)
      • Houma, Louisiana, Forenede Stater, 70360
        • Terrebonne General Medical Center
      • Houma, Louisiana, Forenede Stater, 70360
        • Oncology Center of The South Incorporated
      • Kenner, Louisiana, Forenede Stater, 70065
        • Ochsner Medical Center Kenner
      • Monroe, Louisiana, Forenede Stater, 71202
        • Ochsner LSU Health Monroe Medical Center
      • New Orleans, Louisiana, Forenede Stater, 70121
        • Ochsner Medical Center Jefferson
      • Shreveport, Louisiana, Forenede Stater, 71103
        • LSU Health Sciences Center at Shreveport
      • Shreveport, Louisiana, Forenede Stater, 71101
        • Ochsner LSU Health Saint Mary's Medical Center
    • Maryland
      • Annapolis, Maryland, Forenede Stater, 21401
        • Anne Arundel Medical Center
      • Baltimore, Maryland, Forenede Stater, 21215
        • Sinai Hospital of Baltimore
      • Bethesda, Maryland, Forenede Stater, 20889-5600
        • Walter Reed National Military Medical Center
      • Randallstown, Maryland, Forenede Stater, 21133
        • Northwest Hospital Center
      • Towson, Maryland, Forenede Stater, 21204
        • UM Saint Joseph Medical Center
      • Westminster, Maryland, Forenede Stater, 21157
        • William E Kahlert Regional Cancer Center/Sinai Hospital
    • Massachusetts
      • Pittsfield, Massachusetts, Forenede Stater, 01201
        • Berkshire Medical Center - Cancer Center
      • Springfield, Massachusetts, Forenede Stater, 01104
        • Mercy Medical Center
    • Michigan
      • Ann Arbor, Michigan, Forenede Stater, 48106
        • Saint Joseph Mercy Hospital
      • Battle Creek, Michigan, Forenede Stater, 49017
        • Bronson Battle Creek
      • Brighton, Michigan, Forenede Stater, 48114
        • Saint Joseph Mercy Brighton
      • Brighton, Michigan, Forenede Stater, 48114
        • IHA Hematology Oncology Consultants-Brighton
      • Canton, Michigan, Forenede Stater, 48188
        • Saint Joseph Mercy Canton
      • Canton, Michigan, Forenede Stater, 48188
        • IHA Hematology Oncology Consultants-Canton
      • Caro, Michigan, Forenede Stater, 48723
        • Caro Cancer Center
      • Chelsea, Michigan, Forenede Stater, 48118
        • Saint Joseph Mercy Chelsea
      • Chelsea, Michigan, Forenede Stater, 48118
        • IHA Hematology Oncology Consultants-Chelsea
      • Clarkston, Michigan, Forenede Stater, 48346
        • Hematology Oncology Consultants-Clarkston
      • Clarkston, Michigan, Forenede Stater, 48346
        • Newland Medical Associates-Clarkston
      • Detroit, Michigan, Forenede Stater, 48236
        • Ascension Saint John Hospital
      • East China Township, Michigan, Forenede Stater, 48054
        • Great Lakes Cancer Management Specialists-Doctors Park
      • Escanaba, Michigan, Forenede Stater, 49829
        • Green Bay Oncology - Escanaba
      • Flint, Michigan, Forenede Stater, 48503
        • Hurley Medical Center
      • Flint, Michigan, Forenede Stater, 48503
        • Genesee Cancer and Blood Disease Treatment Center
      • Flint, Michigan, Forenede Stater, 48503
        • Genesee Hematology Oncology PC
      • Flint, Michigan, Forenede Stater, 48503
        • Genesys Hurley Cancer Institute
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Spectrum Health at Butterworth Campus
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Helen DeVos Children's Hospital at Spectrum Health
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Mercy Health Saint Mary's
      • Grosse Pointe Woods, Michigan, Forenede Stater, 48236
        • Academic Hematology Oncology Specialists
      • Grosse Pointe Woods, Michigan, Forenede Stater, 48236
        • Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
      • Grosse Pointe Woods, Michigan, Forenede Stater, 48236
        • Michigan Breast Specialists-Grosse Pointe Woods
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • West Michigan Cancer Center
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • Bronson Methodist Hospital
      • Kalamazoo, Michigan, Forenede Stater, 49048
        • Borgess Medical Center
      • Lansing, Michigan, Forenede Stater, 48912
        • Sparrow Hospital
      • Livonia, Michigan, Forenede Stater, 48154
        • Saint Mary Mercy Hospital
      • Livonia, Michigan, Forenede Stater, 48154
        • Hope Cancer Clinic
      • Macomb, Michigan, Forenede Stater, 48044
        • Great Lakes Cancer Management Specialists-Macomb Medical Campus
      • Macomb, Michigan, Forenede Stater, 48044
        • Michigan Breast Specialists-Macomb Township
      • Marlette, Michigan, Forenede Stater, 48453
        • Saint Mary's Oncology/Hematology Associates of Marlette
      • Muskegon, Michigan, Forenede Stater, 49444
        • Mercy Health Mercy Campus
      • Niles, Michigan, Forenede Stater, 49120
        • Lakeland Hospital Niles
      • Norton Shores, Michigan, Forenede Stater, 49444
        • Cancer and Hematology Centers of Western Michigan - Norton Shores
      • Pontiac, Michigan, Forenede Stater, 48341
        • Saint Joseph Mercy Oakland
      • Pontiac, Michigan, Forenede Stater, 48341
        • 21st Century Oncology-Pontiac
      • Pontiac, Michigan, Forenede Stater, 48341
        • Hope Cancer Center
      • Pontiac, Michigan, Forenede Stater, 48341
        • Newland Medical Associates-Pontiac
      • Reed City, Michigan, Forenede Stater, 49677
        • Spectrum Health Reed City Hospital
      • Rochester Hills, Michigan, Forenede Stater, 48309
        • Great Lakes Cancer Management Specialists-Rochester Hills
      • Saginaw, Michigan, Forenede Stater, 48601
        • Ascension Saint Mary's Hospital
      • Saginaw, Michigan, Forenede Stater, 48604
        • Oncology Hematology Associates of Saginaw Valley PC
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Lakeland Medical Center Saint Joseph
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Marie Yeager Cancer Center
      • Sterling Heights, Michigan, Forenede Stater, 48312
        • Bhadresh Nayak MD PC-Sterling Heights
      • Tawas City, Michigan, Forenede Stater, 48764
        • Ascension Saint Joseph Hospital
      • Traverse City, Michigan, Forenede Stater, 49684
        • Munson Medical Center
      • Warren, Michigan, Forenede Stater, 48093
        • Saint John Macomb-Oakland Hospital
      • Warren, Michigan, Forenede Stater, 48088
        • Advanced Breast Care Center PLLC
      • Warren, Michigan, Forenede Stater, 48093
        • Great Lakes Cancer Management Specialists-Macomb Professional Building
      • Warren, Michigan, Forenede Stater, 48093
        • Macomb Hematology Oncology PC
      • Warren, Michigan, Forenede Stater, 48093
        • Michigan Breast Specialists-Warren
      • West Branch, Michigan, Forenede Stater, 48661
        • Saint Mary's Oncology/Hematology Associates of West Branch
      • Wyoming, Michigan, Forenede Stater, 49519
        • Metro Health Hospital
      • Ypsilanti, Michigan, Forenede Stater, 48106
        • Huron Gastroenterology PC
      • Ypsilanti, Michigan, Forenede Stater, 48197
        • IHA Hematology Oncology Consultants-Ann Arbor
    • Minnesota
      • Bemidji, Minnesota, Forenede Stater, 56601
        • Sanford Joe Lueken Cancer Center
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Fairview Ridges Hospital
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Minnesota Oncology - Burnsville
      • Cambridge, Minnesota, Forenede Stater, 55008
        • Cambridge Medical Center
      • Coon Rapids, Minnesota, Forenede Stater, 55433
        • Mercy Hospital
      • Edina, Minnesota, Forenede Stater, 55435
        • Fairview Southdale Hospital
      • Fridley, Minnesota, Forenede Stater, 55432
        • Unity Hospital
      • Mankato, Minnesota, Forenede Stater, 56001
        • Mayo Clinic Health Systems-Mankato
      • Maple Grove, Minnesota, Forenede Stater, 55369
        • Fairview Clinics and Surgery Center Maple Grove
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Saint John's Hospital - Healtheast
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Minnesota Oncology Hematology PA-Maplewood
      • Minneapolis, Minnesota, Forenede Stater, 55415
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Abbott-Northwestern Hospital
      • Minneapolis, Minnesota, Forenede Stater, 55454
        • Health Partners Inc
      • Minneapolis, Minnesota, Forenede Stater, 55417
        • Minneapolis VA Medical Center
      • Monticello, Minnesota, Forenede Stater, 55362
        • Monticello Cancer Center
      • New Ulm, Minnesota, Forenede Stater, 56073
        • New Ulm Medical Center
      • Princeton, Minnesota, Forenede Stater, 55371
        • Fairview Northland Medical Center
      • Robbinsdale, Minnesota, Forenede Stater, 55422
        • North Memorial Medical Health Center
      • Rochester, Minnesota, Forenede Stater, 55905
        • Mayo Clinic in Rochester
      • Saint Cloud, Minnesota, Forenede Stater, 56303
        • Coborn Cancer Center at Saint Cloud Hospital
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Paul, Minnesota, Forenede Stater, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • United Hospital
      • Shakopee, Minnesota, Forenede Stater, 55379
        • Saint Francis Regional Medical Center
      • Stillwater, Minnesota, Forenede Stater, 55082
        • Lakeview Hospital
      • Thief River Falls, Minnesota, Forenede Stater, 56701
        • Sanford Thief River Falls Medical Center
      • Waconia, Minnesota, Forenede Stater, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, Forenede Stater, 56201
        • Rice Memorial Hospital
      • Woodbury, Minnesota, Forenede Stater, 55125
        • Minnesota Oncology Hematology PA-Woodbury
      • Worthington, Minnesota, Forenede Stater, 56187
        • Sanford Cancer Center Worthington
      • Wyoming, Minnesota, Forenede Stater, 55092
        • Fairview Lakes Medical Center
    • Mississippi
      • Columbus, Mississippi, Forenede Stater, 39705
        • Baptist Memorial Hospital and Cancer Center-Golden Triangle
      • Grenada, Mississippi, Forenede Stater, 38901
        • Baptist Cancer Center-Grenada
      • Hattiesburg, Mississippi, Forenede Stater, 39401
        • Hattiesburg Clinic - Hematology/Oncology Clinic
      • Hattiesburg, Mississippi, Forenede Stater, 39404
        • Forrest General Hospital / Cancer Center
      • New Albany, Mississippi, Forenede Stater, 38652
        • Baptist Memorial Hospital and Cancer Center-Union County
      • Oxford, Mississippi, Forenede Stater, 38655
        • Baptist Memorial Hospital and Cancer Center-Oxford
      • Southhaven, Mississippi, Forenede Stater, 38671
        • Baptist Memorial Hospital and Cancer Center-Desoto
    • Missouri
      • Ballwin, Missouri, Forenede Stater, 63011
        • Saint Louis Cancer and Breast Institute-Ballwin
      • Bolivar, Missouri, Forenede Stater, 65613
        • Central Care Cancer Center - Bolivar
      • Bonne Terre, Missouri, Forenede Stater, 63628
        • Parkland Health Center-Bonne Terre
      • Branson, Missouri, Forenede Stater, 65616
        • Cox Cancer Center Branson
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Saint Francis Medical Center
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Southeast Cancer Center
      • Chesterfield, Missouri, Forenede Stater, 63017
        • Saint Luke's Hospital
      • Columbia, Missouri, Forenede Stater, 65212
        • University of Missouri - Ellis Fischel
      • Farmington, Missouri, Forenede Stater, 63640
        • Parkland Health Center - Farmington
      • Independence, Missouri, Forenede Stater, 64057
        • Centerpoint Medical Center LLC
      • Jefferson City, Missouri, Forenede Stater, 65109
        • Capital Region Southwest Campus
      • Joplin, Missouri, Forenede Stater, 64804
        • Freeman Health System
      • Joplin, Missouri, Forenede Stater, 64804
        • Mercy Hospital Joplin
      • Kansas City, Missouri, Forenede Stater, 64132
        • Research Medical Center
      • Rolla, Missouri, Forenede Stater, 65401
        • Delbert Day Cancer Institute at PCRMC
      • Rolla, Missouri, Forenede Stater, 65401
        • Mercy Clinic-Rolla-Cancer and Hematology
      • Saint Joseph, Missouri, Forenede Stater, 64506
        • Heartland Regional Medical Center
      • Saint Louis, Missouri, Forenede Stater, 63131
        • Missouri Baptist Medical Center
      • Saint Louis, Missouri, Forenede Stater, 63141
        • Mercy Hospital Saint Louis
      • Saint Louis, Missouri, Forenede Stater, 63128
        • Mercy Hospital South
      • Saint Louis, Missouri, Forenede Stater, 63109
        • Saint Louis Cancer and Breast Institute-South City
      • Sainte Genevieve, Missouri, Forenede Stater, 63670
        • Sainte Genevieve County Memorial Hospital
      • Springfield, Missouri, Forenede Stater, 65807
        • CoxHealth South Hospital
      • Springfield, Missouri, Forenede Stater, 65804
        • Mercy Hospital Springfield
      • Sullivan, Missouri, Forenede Stater, 63080
        • Missouri Baptist Sullivan Hospital
      • Sunset Hills, Missouri, Forenede Stater, 63127
        • Missouri Baptist Outpatient Center-Sunset Hills
      • Washington, Missouri, Forenede Stater, 63090
        • Mercy Hospital Washington
    • Montana
      • Anaconda, Montana, Forenede Stater, 59711
        • Community Hospital of Anaconda
      • Billings, Montana, Forenede Stater, 59101
        • Billings Clinic Cancer Center
      • Billings, Montana, Forenede Stater, 59101
        • Saint Vincent Healthcare
      • Billings, Montana, Forenede Stater, 59102
        • Saint Vincent Frontier Cancer Center
      • Bozeman, Montana, Forenede Stater, 59715
        • Bozeman Deaconess Hospital
      • Butte, Montana, Forenede Stater, 59701
        • Saint James Community Hospital and Cancer Treatment Center
      • Great Falls, Montana, Forenede Stater, 59405
        • Great Falls Clinic
      • Great Falls, Montana, Forenede Stater, 59405
        • Benefis Healthcare- Sletten Cancer Institute
      • Helena, Montana, Forenede Stater, 59601
        • Saint Peter's Community Hospital
      • Kalispell, Montana, Forenede Stater, 59901
        • Kalispell Regional Medical Center
      • Missoula, Montana, Forenede Stater, 59804
        • Community Medical Hospital
    • Nebraska
      • Lincoln, Nebraska, Forenede Stater, 68506
        • Nebraska Hematology and Oncology
      • Lincoln, Nebraska, Forenede Stater, 68516
        • Southeast Nebraska Cancer Center - 68th Street Place
      • Lincoln, Nebraska, Forenede Stater, 68516
        • Cancer Partners of Nebraska - Pine Lake
      • Norfolk, Nebraska, Forenede Stater, 68701
        • Faith Regional Health Services Carson Cancer Center
      • North Platte, Nebraska, Forenede Stater, 69101
        • Great Plains Health Callahan Cancer Center
      • Omaha, Nebraska, Forenede Stater, 68124
        • Nebraska Cancer Specialists - Omaha
      • Omaha, Nebraska, Forenede Stater, 68130
        • Oncology Hematology West PC
      • Scottsbluff, Nebraska, Forenede Stater, 69361
        • Regional West Medical Center Cancer Center
    • Nevada
      • Carson City, Nevada, Forenede Stater, 89703
        • Carson Tahoe Regional Medical Center
      • Henderson, Nevada, Forenede Stater, 89052
        • Comprehensive Cancer Centers of Nevada - Henderson
      • Henderson, Nevada, Forenede Stater, 89052
        • OptumCare Cancer Care at Seven Hills
      • Henderson, Nevada, Forenede Stater, 89052
        • Cancer and Blood Specialists-Henderson
      • Henderson, Nevada, Forenede Stater, 89052
        • Las Vegas Cancer Center-Henderson
      • Henderson, Nevada, Forenede Stater, 89074
        • Comprehensive Cancer Centers of Nevada-Southeast Henderson
      • Henderson, Nevada, Forenede Stater, 89074
        • 21st Century Oncology-Henderson
      • Henderson, Nevada, Forenede Stater, 89052
        • Comprehensive Cancer Centers of Nevada-Horizon Ridge
      • Henderson, Nevada, Forenede Stater, 89074
        • Las Vegas Urology - Green Valley
      • Henderson, Nevada, Forenede Stater, 89074
        • Las Vegas Urology - Pebble
      • Henderson, Nevada, Forenede Stater, 89074
        • Urology Specialists of Nevada - Green Valley
      • Las Vegas, Nevada, Forenede Stater, 89144
        • Summerlin Hospital Medical Center
      • Las Vegas, Nevada, Forenede Stater, 89109
        • Sunrise Hospital and Medical Center
      • Las Vegas, Nevada, Forenede Stater, 89102
        • OptumCare Cancer Care at Charleston
      • Las Vegas, Nevada, Forenede Stater, 89106
        • Radiation Oncology Centers of Nevada Central
      • Las Vegas, Nevada, Forenede Stater, 89119
        • Radiation Oncology Centers of Nevada Southeast
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Comprehensive Cancer Centers of Nevada - Northwest
      • Las Vegas, Nevada, Forenede Stater, 89128
        • OptumCare Cancer Care at MountainView
      • Las Vegas, Nevada, Forenede Stater, 89135
        • Alliance for Childhood Diseases/Cure 4 the Kids Foundation
      • Las Vegas, Nevada, Forenede Stater, 89144
        • Comprehensive Cancer Centers of Nevada - Town Center
      • Las Vegas, Nevada, Forenede Stater, 89144
        • Comprehensive Cancer Centers of Nevada-Summerlin
      • Las Vegas, Nevada, Forenede Stater, 89148
        • Comprehensive Cancer Centers of Nevada
      • Las Vegas, Nevada, Forenede Stater, 89148
        • OptumCare Cancer Care at Fort Apache
      • Las Vegas, Nevada, Forenede Stater, 89169
        • Comprehensive Cancer Centers of Nevada - Central Valley
      • Las Vegas, Nevada, Forenede Stater, 89102
        • University Medical Center of Southern Nevada
      • Las Vegas, Nevada, Forenede Stater, 89109
        • HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
      • Las Vegas, Nevada, Forenede Stater, 89113
        • HealthCare Partners Medical Group Oncology/Hematology-San Martin
      • Las Vegas, Nevada, Forenede Stater, 89128
        • HealthCare Partners Medical Group Oncology/Hematology-Tenaya
      • Las Vegas, Nevada, Forenede Stater, 89148-2405
        • Las Vegas Cancer Center-Medical Center
      • Las Vegas, Nevada, Forenede Stater, 89149
        • HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
      • Las Vegas, Nevada, Forenede Stater, 89109
        • 21st Century Oncology
      • Las Vegas, Nevada, Forenede Stater, 89128
        • 21st Century Oncology-Vegas Tenaya
      • Las Vegas, Nevada, Forenede Stater, 89148
        • 21st Century Oncology-Fort Apache
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Ann M Wierman MD LTD
      • Las Vegas, Nevada, Forenede Stater, 89074
        • Las Vegas Urology - Pecos
      • Las Vegas, Nevada, Forenede Stater, 89102
        • Desert West Surgery
      • Las Vegas, Nevada, Forenede Stater, 89103
        • Hope Cancer Care of Nevada
      • Las Vegas, Nevada, Forenede Stater, 89106
        • Urology Specialists of Nevada - Central
      • Las Vegas, Nevada, Forenede Stater, 89113
        • Las Vegas Prostate Cancer Center
      • Las Vegas, Nevada, Forenede Stater, 89113
        • Las Vegas Urology - Sunset
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Las Vegas Urology - Cathedral Rock
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Las Vegas Urology - Smoke Ranch
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Urology Specialists of Nevada - Northwest
      • Las Vegas, Nevada, Forenede Stater, 89148
        • Urology Specialists of Nevada - Southwest
      • Las Vegas, Nevada, Forenede Stater, 89169
        • University Cancer Center
      • Pahrump, Nevada, Forenede Stater, 89048
        • Hope Cancer Care of Nevada-Pahrump
      • Reno, Nevada, Forenede Stater, 89502
        • Renown Regional Medical Center
      • Reno, Nevada, Forenede Stater, 89503
        • Saint Mary's Regional Medical Center
      • Reno, Nevada, Forenede Stater, 89509
        • Radiation Oncology Associates
    • New York
      • Auburn, New York, Forenede Stater, 13021
        • Hematology Oncology Associates of Central New York-Auburn
      • Bay Shore, New York, Forenede Stater, 11706
        • Northwell Health Imbert Cancer Center
      • Bronx, New York, Forenede Stater, 10468
        • James J Peters VA Medical Center
      • Brooklyn, New York, Forenede Stater, 11215
        • New York-Presbyterian/Brooklyn Methodist Hospital
      • East Syracuse, New York, Forenede Stater, 13057
        • Hematology Oncology Associates of Central New York-East Syracuse
      • Elmira, New York, Forenede Stater, 14905
        • Arnot Ogden Medical Center/Falck Cancer Center
      • Glens Falls, New York, Forenede Stater, 12801
        • Glens Falls Hospital
      • Lake Success, New York, Forenede Stater, 11042
        • Northwell Health/Center for Advanced Medicine
      • New York, New York, Forenede Stater, 10065
        • NYP/Weill Cornell Medical Center
      • Syracuse, New York, Forenede Stater, 13215
        • Hematology Oncology Associates of Central New York-Onondaga Hill
    • North Carolina
      • Asheville, North Carolina, Forenede Stater, 28803
        • AdventHealth Infusion Center Asheville
      • Clyde, North Carolina, Forenede Stater, 28721
        • AdventHealth Infusion Center Haywood
      • Fayetteville, North Carolina, Forenede Stater, 28304
        • Cape Fear Valley Health System
      • Gastonia, North Carolina, Forenede Stater, 28054
        • CaroMont Regional Medical Center
      • Hendersonville, North Carolina, Forenede Stater, 28792
        • AdventHealth Hendersonville
      • New Bern, North Carolina, Forenede Stater, 28561
        • CarolinaEast Medical Center
      • New Bern, North Carolina, Forenede Stater, 28562
        • CarolinaEast Oncology and Hematology Associates
      • Washington, North Carolina, Forenede Stater, 27889
        • Marion L Shepard Cancer Center at Vidant Beaufort Hospital
      • Weaverville, North Carolina, Forenede Stater, 28787
        • AdventHealth Infusion Center Weaverville
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Sanford Bismarck Medical Center
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Roger Maris Cancer Center
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Broadway Medical Center
      • Fargo, North Dakota, Forenede Stater, 58103
        • Sanford South University Medical Center
      • Grand Forks, North Dakota, Forenede Stater, 58201
        • Altru Cancer Center
    • Ohio
      • Alliance, Ohio, Forenede Stater, 44601
        • Aultman Alliance Community Hospital
      • Beavercreek, Ohio, Forenede Stater, 45431
        • Indu and Raj Soin Medical Center
      • Boardman, Ohio, Forenede Stater, 44512
        • Saint Elizabeth Boardman Hospital
      • Canton, Ohio, Forenede Stater, 44710
        • Aultman Health Foundation
      • Centerville, Ohio, Forenede Stater, 45459
        • Miami Valley Hospital South
      • Centerville, Ohio, Forenede Stater, 45459
        • Dayton Physicians LLC-Miami Valley South
      • Cincinnati, Ohio, Forenede Stater, 45236
        • Oncology Hematology Care Inc-Kenwood
      • Dayton, Ohio, Forenede Stater, 45406
        • Good Samaritan Hospital - Dayton
      • Dayton, Ohio, Forenede Stater, 45409
        • Miami Valley Hospital
      • Dayton, Ohio, Forenede Stater, 45415
        • Dayton Physician LLC-Miami Valley Hospital North
      • Dayton, Ohio, Forenede Stater, 45415
        • Miami Valley Hospital North
      • Dayton, Ohio, Forenede Stater, 45428
        • Dayton Veterans Affairs Medical Center
      • Findlay, Ohio, Forenede Stater, 45840
        • Blanchard Valley Hospital
      • Findlay, Ohio, Forenede Stater, 45840
        • Armes Family Cancer Center
      • Findlay, Ohio, Forenede Stater, 45840
        • Orion Cancer Care
      • Franklin, Ohio, Forenede Stater, 45005-1066
        • Atrium Medical Center-Middletown Regional Hospital
      • Franklin, Ohio, Forenede Stater, 45005
        • Dayton Physicians LLC-Atrium
      • Greenville, Ohio, Forenede Stater, 45331
        • Wayne Hospital
      • Greenville, Ohio, Forenede Stater, 45331
        • Dayton Physicians LLC-Wayne
      • Kettering, Ohio, Forenede Stater, 45429
        • Kettering Medical Center
      • Kettering, Ohio, Forenede Stater, 45409
        • Greater Dayton Cancer Center
      • Kettering, Ohio, Forenede Stater, 45420
        • First Dayton Cancer Care
      • Springfield, Ohio, Forenede Stater, 45505
        • Springfield Regional Medical Center
      • Springfield, Ohio, Forenede Stater, 45504
        • Springfield Regional Cancer Center
      • Troy, Ohio, Forenede Stater, 45373
        • Upper Valley Medical Center
      • Troy, Ohio, Forenede Stater, 45373
        • Dayton Physicians LLC-Upper Valley
      • Warren, Ohio, Forenede Stater, 44484
        • Saint Joseph Warren Hospital
      • Youngstown, Ohio, Forenede Stater, 44501
        • Saint Elizabeth Youngstown Hospital
    • Oklahoma
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • University of Oklahoma Health Sciences Center
      • Oklahoma City, Oklahoma, Forenede Stater, 73120
        • Mercy Hospital Oklahoma City
    • Oregon
      • Baker City, Oregon, Forenede Stater, 97814
        • Saint Alphonsus Medical Center-Baker City
      • Gresham, Oregon, Forenede Stater, 97030
        • Legacy Mount Hood Medical Center
      • Ontario, Oregon, Forenede Stater, 97914
        • Saint Alphonsus Medical Center-Ontario
      • Portland, Oregon, Forenede Stater, 97210
        • Legacy Good Samaritan Hospital and Medical Center
      • Tualatin, Oregon, Forenede Stater, 97062
        • Legacy Meridian Park Hospital
    • Pennsylvania
      • Allentown, Pennsylvania, Forenede Stater, 18103
        • Lehigh Valley Hospital-Cedar Crest
      • Bethlehem, Pennsylvania, Forenede Stater, 18017
        • Lehigh Valley Hospital - Muhlenberg
      • Danville, Pennsylvania, Forenede Stater, 17822
        • Geisinger Medical Center
      • East Stroudsburg, Pennsylvania, Forenede Stater, 18301
        • Pocono Medical Center
      • Hazleton, Pennsylvania, Forenede Stater, 18201
        • Geisinger Medical Center-Cancer Center Hazleton
      • Hazleton, Pennsylvania, Forenede Stater, 18201
        • Lehigh Valley Hospital-Hazleton
      • Lewisburg, Pennsylvania, Forenede Stater, 17837
        • Geisinger Medical Oncology-Lewisburg
      • Lewistown, Pennsylvania, Forenede Stater, 17044
        • Lewistown Hospital
      • Phoenixville, Pennsylvania, Forenede Stater, 19460
        • Phoenixville Hospital
      • Pottstown, Pennsylvania, Forenede Stater, 19464
        • Pottstown Hospital
      • Pottsville, Pennsylvania, Forenede Stater, 17901
        • Geisinger Cancer Services-Pottsville
      • Sayre, Pennsylvania, Forenede Stater, 18840
        • Guthrie Medical Group PC-Robert Packer Hospital
      • Scranton, Pennsylvania, Forenede Stater, 18510
        • Community Medical Center
      • Selinsgrove, Pennsylvania, Forenede Stater, 17870
        • Geisinger Medical Oncology-Selinsgrove
      • State College, Pennsylvania, Forenede Stater, 16801
        • Geisinger Medical Group
      • Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
        • Geisinger Wyoming Valley/Henry Cancer Center
    • South Carolina
      • Boiling Springs, South Carolina, Forenede Stater, 29316
        • Prisma Health Cancer Institute - Spartanburg
      • Charleston, South Carolina, Forenede Stater, 29401
        • Ralph H Johnson VA Medical Center
      • Clinton, South Carolina, Forenede Stater, 29325
        • Prisma Health Cancer Institute - Laurens
      • Easley, South Carolina, Forenede Stater, 29640
        • Prisma Health Cancer Institute - Easley
      • Georgetown, South Carolina, Forenede Stater, 29440
        • Tidelands Georgetown Memorial Hospital
      • Greenville, South Carolina, Forenede Stater, 29605
        • Prisma Health Cancer Institute - Faris
      • Greenville, South Carolina, Forenede Stater, 29615
        • Prisma Health Cancer Institute - Eastside
      • Greenville, South Carolina, Forenede Stater, 29605
        • Prisma Health Cancer Institute - Butternut
      • Greenville, South Carolina, Forenede Stater, 29605
        • Prisma Health Greenville Memorial Hospital
      • Greenwood, South Carolina, Forenede Stater, 29646
        • Self Regional Healthcare
      • Greer, South Carolina, Forenede Stater, 29650
        • Prisma Health Cancer Institute - Greer
      • Seneca, South Carolina, Forenede Stater, 29672
        • Prisma Health Cancer Institute - Seneca
    • South Dakota
      • Rapid City, South Dakota, Forenede Stater, 57701
        • Rapid City Regional Hospital
      • Sioux Falls, South Dakota, Forenede Stater, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
      • Sioux Falls, South Dakota, Forenede Stater, 57104
        • Sanford Cancer Center Oncology Clinic
    • Tennessee
      • Collierville, Tennessee, Forenede Stater, 38017
        • Baptist Memorial Hospital and Cancer Center-Collierville
      • Memphis, Tennessee, Forenede Stater, 38120
        • Baptist Memorial Hospital and Cancer Center-Memphis
    • Texas
      • Baytown, Texas, Forenede Stater, 77521
        • Houston Methodist San Jacinto Hospital
      • Houston, Texas, Forenede Stater, 77030
        • Houston Methodist Hospital
      • Houston, Texas, Forenede Stater, 77070
        • Methodist Willowbrook Hospital
      • Houston, Texas, Forenede Stater, 77094
        • Houston Methodist West Hospital
      • Nassau Bay, Texas, Forenede Stater, 77058
        • Houston Methodist Saint John Hospital
      • Sugar Land, Texas, Forenede Stater, 77479
        • Houston Methodist Sugar Land Hospital
      • The Woodlands, Texas, Forenede Stater, 77385
        • Houston Methodist The Woodlands Hospital
    • Utah
      • American Fork, Utah, Forenede Stater, 84003
        • American Fork Hospital / Huntsman Intermountain Cancer Center
      • Cedar City, Utah, Forenede Stater, 84720
        • Sandra L Maxwell Cancer Center
      • Logan, Utah, Forenede Stater, 84321
        • Logan Regional Hospital
      • Murray, Utah, Forenede Stater, 84107
        • Intermountain Medical Center
      • Ogden, Utah, Forenede Stater, 84403
        • McKay-Dee Hospital Center
      • Provo, Utah, Forenede Stater, 84604
        • Utah Valley Regional Medical Center
      • Riverton, Utah, Forenede Stater, 84065
        • Riverton Hospital
      • Saint George, Utah, Forenede Stater, 84770
        • Dixie Medical Center Regional Cancer Center
      • Salt Lake City, Utah, Forenede Stater, 84106
        • Utah Cancer Specialists-Salt Lake City
      • Salt Lake City, Utah, Forenede Stater, 84143
        • LDS Hospital
    • Vermont
      • Berlin, Vermont, Forenede Stater, 05602
        • Central Vermont Medical Center/National Life Cancer Treatment
      • Burlington, Vermont, Forenede Stater, 05401
        • University of Vermont Medical Center
      • Burlington, Vermont, Forenede Stater, 05405
        • University of Vermont and State Agricultural College
    • Virginia
      • Fishersville, Virginia, Forenede Stater, 22939
        • Augusta Health Center for Cancer and Blood Disorders
    • Washington
      • Auburn, Washington, Forenede Stater, 98001
        • MultiCare Auburn Medical Center
      • Bellevue, Washington, Forenede Stater, 98004
        • Overlake Medical Center
      • Gig Harbor, Washington, Forenede Stater, 98335
        • MultiCare Gig Harbor Medical Park
      • Port Townsend, Washington, Forenede Stater, 98368
        • Jefferson Healthcare
      • Puyallup, Washington, Forenede Stater, 98372
        • MultiCare Good Samaritan Hospital
      • Renton, Washington, Forenede Stater, 98055
        • Valley Medical Center
      • Spokane, Washington, Forenede Stater, 99204
        • MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
      • Spokane, Washington, Forenede Stater, 99218
        • MultiCare Deaconess Cancer and Blood Specialty Center - North
      • Spokane Valley, Washington, Forenede Stater, 99216
        • MultiCare Deaconess Cancer and Blood Specialty Center - Valley
      • Tacoma, Washington, Forenede Stater, 98405
        • Mary Bridge Children's Hospital and Health Center
      • Tacoma, Washington, Forenede Stater, 98405
        • MultiCare Tacoma General Hospital
      • Vancouver, Washington, Forenede Stater, 98686
        • Legacy Salmon Creek Hospital
      • Vancouver, Washington, Forenede Stater, 98684
        • Legacy Cancer Institute Medical Oncology and Day Treatment
      • Yakima, Washington, Forenede Stater, 98902
        • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
    • West Virginia
      • Huntington, West Virginia, Forenede Stater, 25701
        • Edwards Comprehensive Cancer Center
      • Huntington, West Virginia, Forenede Stater, 25702
        • Saint Mary's Medical Center
    • Wisconsin
      • Burlington, Wisconsin, Forenede Stater, 53105
        • Aurora Cancer Care-Southern Lakes VLCC
      • Chippewa Falls, Wisconsin, Forenede Stater, 54729
        • Marshfield Clinic-Chippewa Center
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Marshfield Medical Center-EC Cancer Center
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Mayo Clinic Health System-Eau Claire Clinic
      • Eau Claire, Wisconsin, Forenede Stater, 54703
        • Mayo Clinic Health System Eau Claire Hospital-Luther Campus
      • Fond Du Lac, Wisconsin, Forenede Stater, 54937
        • Aurora Health Center-Fond du Lac
      • Germantown, Wisconsin, Forenede Stater, 53022
        • Aurora Health Care Germantown Health Center
      • Grafton, Wisconsin, Forenede Stater, 53024
        • Aurora Cancer Care-Grafton
      • Green Bay, Wisconsin, Forenede Stater, 54311
        • Aurora BayCare Medical Center
      • Green Bay, Wisconsin, Forenede Stater, 54301
        • Saint Vincent Hospital Cancer Center Green Bay
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • Saint Vincent Hospital Cancer Center at Saint Mary's
      • Kenosha, Wisconsin, Forenede Stater, 53142
        • Aurora Cancer Care-Kenosha South
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Mayo Clinic Health System-Franciscan Healthcare
      • Ladysmith, Wisconsin, Forenede Stater, 54848
        • Marshfield Clinic - Ladysmith Center
      • Manitowoc, Wisconsin, Forenede Stater, 54221
        • Holy Family Memorial Hospital
      • Marinette, Wisconsin, Forenede Stater, 54143
        • Aurora Bay Area Medical Group-Marinette
      • Marinette, Wisconsin, Forenede Stater, 54143
        • Saint Vincent Hospital Cancer Center at Marinette
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Marshfield Medical Center-Marshfield
      • Milwaukee, Wisconsin, Forenede Stater, 53209
        • Aurora Cancer Care-Milwaukee
      • Milwaukee, Wisconsin, Forenede Stater, 53215
        • Aurora Saint Luke's Medical Center
      • Milwaukee, Wisconsin, Forenede Stater, 53233
        • Aurora Sinai Medical Center
      • Minocqua, Wisconsin, Forenede Stater, 54548
        • Marshfield Clinic-Minocqua Center
      • Mukwonago, Wisconsin, Forenede Stater, 53149
        • ProHealth D N Greenwald Center
      • New Richmond, Wisconsin, Forenede Stater, 54017
        • Cancer Center of Western Wisconsin
      • Oconomowoc, Wisconsin, Forenede Stater, 53066
        • ProHealth Oconomowoc Memorial Hospital
      • Oconto Falls, Wisconsin, Forenede Stater, 54154
        • Saint Vincent Hospital Cancer Center at Oconto Falls
      • Oshkosh, Wisconsin, Forenede Stater, 54904
        • Vince Lombardi Cancer Clinic - Oshkosh
      • Racine, Wisconsin, Forenede Stater, 53406
        • Aurora Cancer Care-Racine
      • Rice Lake, Wisconsin, Forenede Stater, 54868
        • Marshfield Medical Center-Rice Lake
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • Vince Lombardi Cancer Clinic-Sheboygan
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • HSHS Saint Nicholas Hospital
      • Stevens Point, Wisconsin, Forenede Stater, 54482
        • Marshfield Clinic Stevens Point Center
      • Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
        • Saint Vincent Hospital Cancer Center at Sturgeon Bay
      • Summit, Wisconsin, Forenede Stater, 53066
        • Aurora Medical Center in Summit
      • Two Rivers, Wisconsin, Forenede Stater, 54241
        • Vince Lombardi Cancer Clinic-Two Rivers
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • UW Cancer Center at ProHealth Care
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • ProHealth Waukesha Memorial Hospital
      • Wausau, Wisconsin, Forenede Stater, 54401
        • Marshfield Clinic-Wausau Center
      • Wauwatosa, Wisconsin, Forenede Stater, 53226
        • Aurora Cancer Care-Milwaukee West
      • West Allis, Wisconsin, Forenede Stater, 53227
        • Aurora West Allis Medical Center
      • Weston, Wisconsin, Forenede Stater, 54476
        • Marshfield Medical Center - Weston
      • Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
        • Marshfield Clinic - Wisconsin Rapids Center
    • Wyoming
      • Cheyenne, Wyoming, Forenede Stater, 82001
        • Cheyenne Regional Medical Center-West
      • Cody, Wyoming, Forenede Stater, 82414
        • Billings Clinic-Cody
      • Sheridan, Wyoming, Forenede Stater, 82801
        • Welch Cancer Center
  • Guam
      • Tamuning, Guam, 96913
        • FHP Health Center-Guam

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

  • Diagnose af ondartet sygdom på ethvert stadium; (trin I til trin IV)
  • Ingen tidligere historie med kemoterapi for nogen malignitet
  • Planlagt at modtage intravenøs HEC (meget emetogen kemoterapi) (enten cisplatinholdigt regime eller doxorubicin og cyclophosphamid [AC]); cisplatin givet på en enkelt dag i en dosis på >= 70 mg/m^2, med eller uden andre kemoterapimidler ELLER doxorubicin (60 mg/m^2) plus cyclophosphamid (600 mg/m^2)
  • Ingen kvalme eller opkastning =< 24 timer før tilmelding

  • Negativ graviditetstest (serum eller urin) udført =< 7 dage før registrering, kun for kvinder i den fødedygtige alder

    * En kvinde i den fødedygtige alder er en kønsmoden kvinde, der: 1) ikke har gennemgået en hysterektomi eller bilateral ooforektomi; eller 2) ikke har været naturligt postmenopausal i mindst 12 på hinanden følgende måneder (dvs. har haft menstruation på noget tidspunkt i de foregående 12 på hinanden følgende måneder)

  • Ingen kendt diagnose af demens; patienter med stabile behandlede hjernemetastaser er berettiget til at deltage
  • Ingen kendt historie med sygdom i centralnervesystemet (f.eks. anfaldsforstyrrelse)
  • Ingen behandling med et andet antipsykotisk middel såsom olanzapin, risperidon, quetiapin, clozapin, phenothiazin eller butyrophenon =< 30 dage før registrering
  • Ingen kronisk phenothiazin-administration som et antipsykotisk middel (patienter kan modtage prochlorperazin og andre phenothiaziner som rednings-anti-emetikum, men ikke inden for 24 timer før registrering)
  • Ingen brug af amifostin inden for 7 dage før registrering
  • Ingen strålebehandling inden for 7 dage før registrering eller planlagt i en uge efter den aktuelle dosis kemoterapi
  • Ingen brug af quinolon-antibiotisk behandling inden for 7 dage før registrering
  • Ingen kronisk alkoholisme (som bestemt af efterforskeren)
  • Ingen kendt overfølsomhed over for olanzapin
  • Ingen kendt ukontrolleret hjertearytmi, ingen kendt ukontrolleret kongestiv hjerteinsufficiens eller ingen akut myokardieinfarkt inden for de foregående seks måneder
  • Ingen historie med ukontrolleret diabetes mellitus, dvs. ingen diabetisk ketoacidose; inden for 6 måneder før registrering; patienter er berettigede, hvis de har kontrolleret diabetes på diæt, orale midler og/eller insulin
  • Eastern Cooperative Oncology Group (ECOG) præstationsstatus 0, 1 eller 2
  • Patienterne skal kunne læse og forstå engelsk; lokal oversættelse, herunder verbal oversættelse af patientrapporterede resultater (PRO'er), er ikke tilladt
  • Serumkreatinin =< 2,0 mg/dL =< 120 dage før registrering
  • Aspartataminotransferase (AST) eller alaninaminotransferase (ALT) =< 3 x øvre normalgrænse (ULN) =< 120 dage før registrering

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Støttende pleje
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Dobbelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: Arm I (fosaprepitant dimeglumin, olanzapin)
Patienterne får palonosetronhydrochlorid IV over 30 sekunder eller ondansetronhydrochlorid IV over 2-5 minutter eller PO på dag 1, dexamethason PO på dag 1-4, fosaprepitant dimeglumine IV over 20-30 minutter på dag 1, og olanzapin PO på dag 1- 4. Behandlingen kan gentages hver 4. dag i op til 3 forløb i fravær af sygdomsprogression eller uacceptabel toksicitet.
Medicin: Dexamethason
Givet PO
Medicin: Olanzapin
Givet PO
Medicin: Fosaprepitant Dimeglumine
Givet IV
Medicin: Palonosetron Hydrochlorid
Givet IV
Medicin: Ondansetron Hydrochlorid
Givet IV eller PO
Aktiv komparator: Arm II (placebo, olanzapin)
Patienterne får palonosetronhydrochlorid IV over 30 sekunder eller ondansetronhydrochlorid IV over 2-5 minutter eller PO på dag 1, dexamethason PO på dag 1-4, placebo IV over 20-30 minutter på dag 1 og olanzapin PO på dag 1-4 . Behandling (uden placebo) kan gentages hver 4. dag i op til 3 kure i fravær af sygdomsprogression eller uacceptabel toksicitet.
Medicin: Dexamethason
Givet PO
Andet: Placebo
Givet IV
Medicin: Olanzapin
Givet PO
Medicin: Palonosetron Hydrochlorid
Givet IV
Medicin: Ondansetron Hydrochlorid
Givet IV eller PO

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Ingen kvalmefrekvens Defineret som et svar på 0 i kvalmeposten i dagbog/spørgeskema for kvalme og opkastning i de samlede (0-120 timer), akutte (0-24 timer) og forsinkede (24-120 timer) perioder
Tidsramme: Op til 120 timer
Det specifikke mål vil være baseret på andelen af ​​patienter med en værdi på 0, målt ved det enkelte kvalmepunkt (skala 0-10, 0 er ingen symptomer, 10 er værste symptomer) i spørgeskemaet. Et modificeret intention-to-treat princip vil blive anvendt til statistisk analyse af effektivitet hos evaluerbare patienter. Andelene af patienter uden kvalme i den samlede, akutte og forsinkede periode vil blive opsummeret efter behandlingsarm. De vil blive testet på en sekventiel måde ved at bruge en Simes gatekeeping-procedure for at opretholde det overordnede signifikansniveau på det specificerede af Lan-DeMets-familiens alfa-forbrugsfunktion. Forskellen i proportioner uden kvalme mellem arme vil blive estimeret sammen med et ensidigt 95 % konfidensinterval. Testene og konfidensintervallerne vil blive konstrueret ved brug af normal tilnærmelse af binomialfordelingen justeret for ikke-mindreværdsmarginen.
Op til 120 timer

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Fuldstændig respons (CR) (ingen emetiske episoder og ingen brug af redningsmedicin) under de akutte, forsinkede og de overordnede perioder målt ved kvalme og opkastning daglig dagbog/spørgeskema
Tidsramme: Op til 120 timer
Den specifikke foranstaltning vil være baseret på andelen af ​​patienter, der svarede "Ingen" på både spørgsmål vedrørende opkastningsepisoden (ingen, én gang, to gange, mere end to gange) og antallet af ekstra kvalme-/opkastningspiller taget (ingen, én, to, mere end to) i den daglige dagbog/spørgeskema for kvalme og opkastning. CR-raten for den samlede, akutte og forsinkede periode vil blive opsummeret efter behandlingsarm og vil blive sammenlignet ved hjælp af en Chi-kvadrat-test. Forskellen i CR-rater mellem arme vil blive estimeret sammen med et 95 % konfidensinterval.
Op til 120 timer
Potentielle toksiciteter som tilskrevet olanzapin målt ved kvalme og opkastning daglig dagbog/spørgeskema
Tidsramme: Op til 120 timer
Potentielle toksiciteter omfatter kvalme, uønsket sedation og uønsket appetit, målt ved tre individuelle punkter (kvalme, uønsket sedation, uønsket appetit) i kvalme- og opkastnings daglige mejeri/spørgeskema (skala 0-10, 0 er ingen symptomer, 10 er de værste symptomer ). Forekomster af toksicitet vil blive opsummeret efter type og efter behandlingsarm. Forekomster af toksicitet vil blive sammenlignet mellem arme ved hjælp af en Chi-kvadrat-test eller Fishers eksakte test, alt efter hvad der er relevant. Derudover vil uønsket sedation og appetitforøgelse, som indsamlet i den daglige kvalme- og opkastningsdagbog/spørgeskemaet, blive analyseret ved hjælp af analyser med gentagne mål, herunder beskrivende statistikker, grafiske tilgange og vækstkurvemodeller for at tage højde for faktoren dag- og tidstendens.
Op til 120 timer
Gennemsnitlig kvalme-score (0-10) Gentagne gange målt ved kvalme- og opkastningsdagbog/spørgeskema
Tidsramme: Op til 1 år
Den specifikke foranstaltning vil være baseret på den enkelte kvalmepost (skala 0-10, 0 er ingen symptomer, 10 er de værste symptomer) i den daglige dagbog/spørgeskema for kvalme og opkastning. Kvalme-scorer (0-10) gentagne gange målt af kvalme- og opkastningsdagbogen/spørgeskemaet vil blive analyseret ved hjælp af gentagne målinger og vækstkurvemodeller som beskrevet ovenfor for uønsket sedation og øget appetit.
Op til 1 år
Samlet hyppighed af redningsmedicin målt ved den daglige dagbog/spørgeskema for kvalme og opkastning
Tidsramme: Over 5 dage pr. hver af de 4 cyklusser
Den specifikke foranstaltning vil være baseret på det enkelte punkt: antal ekstra kvalme-/opkastningspiller taget (ingen, én, to gange, mere end to gange) i dagbogen/spørgeskemaet for kvalme og opkastning.
Over 5 dage pr. hver af de 4 cyklusser

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Alliance for Clinical Trials in Oncology

Samarbejdspartnere

National Cancer Institute (NCI)

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

15. oktober 2018

Primær færdiggørelse (Faktiske)

8. november 2021

Studieafslutning (Faktiske)

1. maj 2023

Datoer for studieregistrering

Først indsendt

25. juni 2018

Først indsendt, der opfyldte QC-kriterier

25. juni 2018

Først opslået (Faktiske)

5. juli 2018

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

8. maj 2023

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

4. maj 2023

Sidst verificeret

1. maj 2023

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • A221602
  • UG1CA189823 (U.S. NIH-bevilling/kontrakt)
  • NCI-2017-02410 (Registry Identifier: NCI Clinical Trial Reporting Program)

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ja

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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Kliniske forsøg med Dexamethason

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Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Egypt

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

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