Duloxetin til forebyggelse af Oxaliplatin-induceret perifer neuropati hos patienter med trin II-III kolorektal cancer
23. januar 2026 opdateret af: Alliance for Clinical Trials in Oncology
Duloxetin til forebyggelse af Oxaliplatin-induceret kemoterapi-induceret perifer neuropati: et randomiseret, dobbeltblindt, placebo-kontrolleret fase II til fase III-studie
Dette fase II/III-studie undersøger den bedste dosis af duloxetin, og hvor godt det virker til at forebygge smerte, prikken og følelsesløshed (perifer neuropati) forårsaget af behandling med oxaliplatin hos patienter med stadium II-III kolorektal cancer.
Duloxetin øger mængden af visse kemikalier i hjernen, der hjælper med at lindre depression og smerte.
At give duloxetin til patienter, der er i behandling med oxaliplatin mod kolorektal cancer, kan hjælpe med at forhindre perifer neuropati.
Studieoversigt
Status
Aktiv, ikke rekrutterende
Detaljeret beskrivelse
Undersøgelsens primære og sekundære mål:
PRIMÆRE MÅL:
I. At bestemme den dosis af duloxetinhydrochlorid (duloxetin) (30 mg eller 60 mg dagligt), der virker mest lovende til forebyggelse af oxaliplatin-induceret perifer neuropati (OIPN). (Fase II)
II. For at demonstrere, at den mest lovende dosis af duloxetin identificeret i fase II-komponenten er mere effektiv end placebo til at forhindre OIPN-sensoriske symptomer. (Fase III)
III. For at demonstrere, at den mest lovende dosis af duloxetin identificeret i fase II-komponenten er mere effektiv end placebo til at forhindre oxaliplatin-induceret kronisk neuropatisk smerte. (Fase III)
SEKUNDÆRE MÅL:
I. At karakterisere toksicitet i hver arm, herunder duloxetin-bivirkninger af kvalme, mundtørhed, svimmelhed, somnolens, træthed og søvnløshed ved at bruge Common Terminology Criteria for Adverse Events (CTCAE) version (v) 5.0. (Fase II)
II. For at sammenligne de serielt målte OIPN total sensorisk neuropati-score beregnet ud fra de seks individuelle livskvalitetsspørgeskema - Kemoterapi-induceret perifer neuropati 20 (QLQ-CIPN20) spørgsmål, der kvantificerer følelsesløshed, prikken og smerter i fingre (eller hænder) og tæer ( eller fødder), målt på dag 1 i hver cyklus af oxaliplatin-behandling og 1 måned efter oxaliplatin-behandling mellem den mest lovende dosis af duloxetin identificeret i fase II-komponenten og placebo. (Fase III)
III. For at sammenligne den serielt målte Brief Pain Inventory Short Form (BPI-SF) patientrapporteret på de gennemsnitlige smertescore, målt på dag 1 i hver cyklus af oxaliplatin-behandling og 1 måned efter oxaliplatin-behandling mellem den mest lovende dosis af duloxetin identificeret i fase II-komponenten og placebo.
IV. At karakterisere toksicitet i hver arm, herunder duloxetin-bivirkninger af kvalme, mundtørhed, svimmelhed, somnolens, træthed og søvnløshed ved brug af CTCAE v 5.0. (Fase III)
OMRIDS:
FASE II: Patienterne randomiseres til 1 ud af 3 arme.
ARM I: Patienter i fase II får duloxetinhydrochlorid 30 mg (1 duloxetinkapsel) oralt (PO) én gang dagligt (QD) i uge 1, duloxetinhydrochlorid 30 mg (1 duloxetinkapsel) PO QD og placebo (1 placebokapsel) PO QD i uge 2-16, efterfulgt af duloxetinhydrochlorid 30 mg (1 duloxetinkapsel) PO QD i uge 17 i fravær af uacceptabel toksicitet.
ARM II: Patienter i fase II får duloxetinhydrochlorid 30 mg (1 duloxetinkapsel) oralt (PO) én gang dagligt (QD) i uge 1, duloxetinhydrochlorid 60 mg (2 duloxetinkapsler) PO QD i uge 2-16, efterfulgt af duloxetin hydrochlorid 30 mg (1 duloxetinkapsel) PO QD i uge 17 i fravær af uacceptabel toksicitet.
ARM III: Patienter i fase II får placebo (1 placebo kapsel) oralt (PO) en gang dagligt (QD) i uge 1, placebo (2 placebo kapsler) PO QD uge 2-16, efterfulgt af placebo (1 placebo kapsel) PO QD i uge 17 i fravær af uacceptabel toksicitet.
FASE III: Patienterne randomiseres til 1 ud af 2 arme.
ARM I: Patienter i fase III modtager den mest lovende dosis duloxetinhydrochlorid fra fase II PO QD i fravær af uacceptabel toksicitet.
ARM II: Patienter i fase III modtager placebo PO QD i fravær af uacceptabel toksicitet.
BEMÆRK: Patienter i alle arme modtager standardbehandling oxaliplatin i uge 1-12.
Efter afslutning af undersøgelsen følges patienterne op 30 dage og 3, 6, 12 og 18 måneder efter sidste oxaliplatinbehandling.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
220
Fase
- Fase 2
- Fase 3
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Alabama
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Birmingham, Alabama, Forenede Stater, 35233
- University of Alabama at Birmingham Cancer Center
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Mobile, Alabama, Forenede Stater, 36688
- University of South Alabama Mitchell Cancer Institute
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Alaska
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Anchorage, Alaska, Forenede Stater, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, Forenede Stater, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, Forenede Stater, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Forenede Stater, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, Forenede Stater, 99504
- Anchorage Radiation Therapy Center
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Arizona
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Kingman, Arizona, Forenede Stater, 86401
- Kingman Regional Medical Center
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Phoenix, Arizona, Forenede Stater, 85004
- Cancer Center at Saint Joseph's
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Arkansas
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Fort Smith, Arkansas, Forenede Stater, 72903
- Mercy Hospital Fort Smith
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Hot Springs, Arkansas, Forenede Stater, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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Little Rock, Arkansas, Forenede Stater, 72205
- University of Arkansas for Medical Sciences
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Little Rock, Arkansas, Forenede Stater, 72205
- CARTI Cancer Center
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Little Rock, Arkansas, Forenede Stater, 72205
- John L McClellan Memorial Veterans Hospital
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California
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Arroyo Grande, California, Forenede Stater, 93420
- PCR Oncology
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Arroyo Grande, California, Forenede Stater, 93420
- Mission Hope Medical Oncology - Arroyo Grande
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Burbank, California, Forenede Stater, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Carmichael, California, Forenede Stater, 95608
- Mercy San Juan Medical Center
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Carmichael, California, Forenede Stater, 95608
- Mercy Cancer Center - Carmichael
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Chico, California, Forenede Stater, 95973
- Adventist Health Cancer Care Center Chico
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Duarte, California, Forenede Stater, 91010
- City of Hope Comprehensive Cancer Center
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Dublin, California, Forenede Stater, 94568
- Epic Care-Dublin
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Elk Grove, California, Forenede Stater, 95758
- Mercy Cancer Center - Elk Grove
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Emeryville, California, Forenede Stater, 94608
- Bay Area Breast Surgeons Inc
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Emeryville, California, Forenede Stater, 94608
- Epic Care Partners in Cancer Care
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Fremont, California, Forenede Stater, 94538
- Washington Hospital
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Lancaster, California, Forenede Stater, 93534
- City of Hope Antelope Valley
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Martinez, California, Forenede Stater, 94553-3156
- Contra Costa Regional Medical Center
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Merced, California, Forenede Stater, 95340
- Mercy Cancer Center
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Napa, California, Forenede Stater, 94558
- Providence Queen of The Valley
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Oakland, California, Forenede Stater, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, Forenede Stater, 94609
- Bay Area Tumor Institute
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Rancho Mirage, California, Forenede Stater, 92270
- Eisenhower Medical Center
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Rocklin, California, Forenede Stater, 95765
- Mercy Cancer Center - Rocklin
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Sacramento, California, Forenede Stater, 95817
- University of California Davis Comprehensive Cancer Center
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Sacramento, California, Forenede Stater, 95816
- Mercy Cancer Center - Sacramento
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San Francisco, California, Forenede Stater, 94110
- Zuckerberg San Francisco General Hospital
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San Luis Obispo, California, Forenede Stater, 93401
- Pacific Central Coast Health Center-San Luis Obispo
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Santa Maria, California, Forenede Stater, 93444
- Mission Hope Medical Oncology - Santa Maria
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Santa Rosa, California, Forenede Stater, 95403
- Providence Medical Foundation - Santa Rosa
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South Pasadena, California, Forenede Stater, 91030
- City of Hope South Pasadena
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Truckee, California, Forenede Stater, 96161
- Gene Upshaw Memorial Tahoe Forest Cancer Center
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Upland, California, Forenede Stater, 91786
- City of Hope Upland
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Walnut Creek, California, Forenede Stater, 94597
- Epic Care Cyberknife Center
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Woodland, California, Forenede Stater, 95695
- Woodland Memorial Hospital
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Colorado
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Colorado Springs, Colorado, Forenede Stater, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Forenede Stater, 80909
- UCHealth Memorial Hospital Central
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Colorado Springs, Colorado, Forenede Stater, 80907
- Rocky Mountain Cancer Centers-Penrose
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Colorado Springs, Colorado, Forenede Stater, 80920
- Memorial Hospital North
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Colorado Springs, Colorado, Forenede Stater, 80923
- Saint Francis Cancer Center
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Denver, Colorado, Forenede Stater, 80210
- Porter Adventist Hospital
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Denver, Colorado, Forenede Stater, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, Forenede Stater, 80218
- SCL Health Saint Joseph Hospital
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Denver, Colorado, Forenede Stater, 80206
- National Jewish Health-Main Campus
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Durango, Colorado, Forenede Stater, 81301
- Mercy Medical Center
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Durango, Colorado, Forenede Stater, 81301
- Southwest Oncology PC
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Fort Collins, Colorado, Forenede Stater, 80524
- Poudre Valley Hospital
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Fort Collins, Colorado, Forenede Stater, 80528
- Cancer Care and Hematology-Fort Collins
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Golden, Colorado, Forenede Stater, 80401
- National Jewish Health-Western Hematology Oncology
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Golden, Colorado, Forenede Stater, 80401
- SCL Health Cancer Centers of Colorado - Lutheran Medical Center
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Grand Junction, Colorado, Forenede Stater, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, Forenede Stater, 80631
- UCHealth Greeley Hospital
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Greeley, Colorado, Forenede Stater, 80631
- Banner North Colorado Medical Center
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Lafayette, Colorado, Forenede Stater, 80026
- Kaiser Permanente-Rock Creek
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Lakewood, Colorado, Forenede Stater, 80228
- Saint Anthony Hospital
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Littleton, Colorado, Forenede Stater, 80122
- Littleton Adventist Hospital
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Lone Tree, Colorado, Forenede Stater, 80124
- Kaiser Permanente-Lone Tree
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Longmont, Colorado, Forenede Stater, 80501
- Longmont United Hospital
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Longmont, Colorado, Forenede Stater, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, Forenede Stater, 80538
- Medical Center of the Rockies
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Loveland, Colorado, Forenede Stater, 80539
- Banner McKee Medical Center
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Parker, Colorado, Forenede Stater, 80138
- Parker Adventist Hospital
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Pueblo, Colorado, Forenede Stater, 81004
- Saint Mary Corwin Medical Center
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Thornton, Colorado, Forenede Stater, 80260
- National Jewish Health-Northern Hematology Oncology
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Wheat Ridge, Colorado, Forenede Stater, 80033
- SCL Health Lutheran Medical Center
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Connecticut
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Hartford, Connecticut, Forenede Stater, 06102
- Hartford Hospital
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Meriden, Connecticut, Forenede Stater, 06451
- Midstate Medical Center
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New Britain, Connecticut, Forenede Stater, 06050
- The Hospital of Central Connecticut
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Stamford, Connecticut, Forenede Stater, 06904
- Stamford Hospital/Bennett Cancer Center
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Delaware
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Frankford, Delaware, Forenede Stater, 19945
- Beebe South Coastal Health Campus
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Lewes, Delaware, Forenede Stater, 19958
- Beebe Medical Center
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Newark, Delaware, Forenede Stater, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Forenede Stater, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Forenede Stater, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Forenede Stater, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, Forenede Stater, 19971
- Beebe Health Campus
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Seaford, Delaware, Forenede Stater, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, Forenede Stater, 19801
- Christiana Care Health System-Wilmington Hospital
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District of Columbia
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Washington D.C., District of Columbia, Forenede Stater, 20010
- Medstar Washington Hospital Center
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Washington D.C., District of Columbia, Forenede Stater, 20002
- Kaiser Permanente-Capitol Hill Medical Center
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Florida
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Altamonte Springs, Florida, Forenede Stater, 32701
- AdventHealth Altamonte
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Aventura, Florida, Forenede Stater, 33180
- Mount Sinai Comprehensive Cancer Center at Aventura
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Celebration, Florida, Forenede Stater, 34747
- AdventHealth Celebration
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Clearwater, Florida, Forenede Stater, 33756
- Morton Plant Hospital
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Coral Gables, Florida, Forenede Stater, 33146
- UM Sylvester Comprehensive Cancer Center at Coral Gables
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Deerfield Beach, Florida, Forenede Stater, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Fort Lauderdale, Florida, Forenede Stater, 33308
- Holy Cross Hospital
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Kissimmee, Florida, Forenede Stater, 34744
- AdventHealth Kissimmee
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Miami, Florida, Forenede Stater, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Miami Beach, Florida, Forenede Stater, 33140
- Mount Sinai Medical Center
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Orlando, Florida, Forenede Stater, 32803
- AdventHealth Orlando
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Orlando, Florida, Forenede Stater, 32803
- AdventHealth Medical Group Urology at Orlando
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Orlando, Florida, Forenede Stater, 32822
- AdventHealth East Orlando
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Plant City, Florida, Forenede Stater, 33563
- South Florida Baptist Hospital
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Safety Harbor, Florida, Forenede Stater, 34695
- Mease Countryside Hospital
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St. Petersburg, Florida, Forenede Stater, 33705
- Saint Anthony's Hospital Cancer Care Center
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Tampa, Florida, Forenede Stater, 33607
- Saint Joseph's Hospital/Children's Hospital-Tampa
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Winter Park, Florida, Forenede Stater, 32792
- AdventHealth Winter Park
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Georgia
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Albany, Georgia, Forenede Stater, 31701
- Phoebe Putney Memorial Hospital
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Augusta, Georgia, Forenede Stater, 30901
- Augusta Oncology Associates PC-D'Antignac
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Augusta, Georgia, Forenede Stater, 30909
- Augusta Oncology Associates PC-Wheeler
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Savannah, Georgia, Forenede Stater, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Hawaii
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Honolulu, Hawaii, Forenede Stater, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Forenede Stater, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Forenede Stater, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Forenede Stater, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, Forenede Stater, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Forenede Stater, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Forenede Stater, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, Forenede Stater, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Forenede Stater, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Forenede Stater, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, Forenede Stater, 96813
- Island Urology
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Honolulu, Hawaii, Forenede Stater, 96817
- Hawaii Diagnostic Radiology Services LLC
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Kahului, Hawaii, Forenede Stater, 96732
- Straub Medical Center - Kahului Clinic
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Kailua, Hawaii, Forenede Stater, 96734
- Castle Medical Center
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Lihue, Hawaii, Forenede Stater, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, Forenede Stater, 96701
- Hawaii Cancer Care - Westridge
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‘Aiea, Hawaii, Forenede Stater, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, Forenede Stater, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, Forenede Stater, 96701
- The Cancer Center of Hawaii-Pali Momi
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‘Aiea, Hawaii, Forenede Stater, 96701
- Straub Pearlridge Clinic
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‘Ewa Beach, Hawaii, Forenede Stater, 96706
- The Queen's Medical Center - West Oahu
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Idaho
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Boise, Idaho, Forenede Stater, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, Forenede Stater, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, Forenede Stater, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, Forenede Stater, 83814
- Kootenai Health - Coeur d'Alene
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Emmett, Idaho, Forenede Stater, 83617
- Walter Knox Memorial Hospital
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Fruitland, Idaho, Forenede Stater, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, Forenede Stater, 83642
- Idaho Urologic Institute-Meridian
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Meridian, Idaho, Forenede Stater, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, Forenede Stater, 83686
- Saint Luke's Cancer Institute - Nampa
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Nampa, Idaho, Forenede Stater, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Post Falls, Idaho, Forenede Stater, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, Forenede Stater, 83864
- Kootenai Clinic Cancer Services - Sandpoint
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Twin Falls, Idaho, Forenede Stater, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Alton, Illinois, Forenede Stater, 62002
- Saint Anthony's Health
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Aurora, Illinois, Forenede Stater, 60504
- Rush - Copley Medical Center
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Bloomington, Illinois, Forenede Stater, 61704
- Illinois CancerCare-Bloomington
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Burr Ridge, Illinois, Forenede Stater, 60527
- Loyola Center for Health at Burr Ridge
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Canton, Illinois, Forenede Stater, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, Forenede Stater, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, Forenede Stater, 62918
- SIH Cancer Institute
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Carthage, Illinois, Forenede Stater, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Forenede Stater, 62801
- Centralia Oncology Clinic
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Centralia, Illinois, Forenede Stater, 62801
- Saint Mary's Hospital
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Chicago, Illinois, Forenede Stater, 60611
- Northwestern University
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Chicago, Illinois, Forenede Stater, 60612
- John H Stroger Jr Hospital of Cook County
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Chicago, Illinois, Forenede Stater, 60612
- Jesse Brown Veterans Affairs Medical Center
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Danville, Illinois, Forenede Stater, 61832
- Carle at The Riverfront
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DeKalb, Illinois, Forenede Stater, 60115
- Northwestern Medicine Cancer Center Kishwaukee
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Decatur, Illinois, Forenede Stater, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Forenede Stater, 62526
- Cancer Care Specialists of Illinois - Decatur
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Dixon, Illinois, Forenede Stater, 61021
- Illinois CancerCare-Dixon
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Effingham, Illinois, Forenede Stater, 62401
- Crossroads Cancer Center
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Effingham, Illinois, Forenede Stater, 62401
- Carle Physician Group-Effingham
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Eureka, Illinois, Forenede Stater, 61530
- Illinois CancerCare-Eureka
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Evanston, Illinois, Forenede Stater, 60201
- NorthShore University HealthSystem-Evanston Hospital
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Galesburg, Illinois, Forenede Stater, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, Forenede Stater, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, Forenede Stater, 60134
- Northwestern Medicine Cancer Center Delnor
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Glenview, Illinois, Forenede Stater, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
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Harvey, Illinois, Forenede Stater, 60426
- Ingalls Memorial Hospital
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Highland Park, Illinois, Forenede Stater, 60035
- NorthShore University HealthSystem-Highland Park Hospital
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Homer Glen, Illinois, Forenede Stater, 60491
- Loyola Medicine Homer Glen
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Joliet, Illinois, Forenede Stater, 60435
- Duly Health and Care Joliet
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Kewanee, Illinois, Forenede Stater, 61443
- Illinois CancerCare-Kewanee Clinic
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Lake Forest, Illinois, Forenede Stater, 60045
- Northwestern Medicine Lake Forest Hospital
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Macomb, Illinois, Forenede Stater, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, Forenede Stater, 61938
- Carle Physician Group-Mattoon/Charleston
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Maywood, Illinois, Forenede Stater, 60153
- Loyola University Medical Center
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Melrose Park, Illinois, Forenede Stater, 60160
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb
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Moline, Illinois, Forenede Stater, 61265
- Trinity Medical Center
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Mount Vernon, Illinois, Forenede Stater, 62864
- Good Samaritan Regional Health Center
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O'Fallon, Illinois, Forenede Stater, 62269
- Cancer Care Center of O'Fallon
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O'Fallon, Illinois, Forenede Stater, 62269
- HSHS Saint Elizabeth's Hospital
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Ottawa, Illinois, Forenede Stater, 61350
- Illinois CancerCare-Ottawa Clinic
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Pekin, Illinois, Forenede Stater, 61554
- Illinois CancerCare-Pekin
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Peoria, Illinois, Forenede Stater, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, Forenede Stater, 61615
- Illinois CancerCare-Peoria
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Peru, Illinois, Forenede Stater, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, Forenede Stater, 61354
- Valley Radiation Oncology
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Princeton, Illinois, Forenede Stater, 61356
- Illinois CancerCare-Princeton
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River Forest, Illinois, Forenede Stater, 60305
- West Suburban Medical Center
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Rockford, Illinois, Forenede Stater, 61108
- OSF Saint Anthony Medical Center
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Shiloh, Illinois, Forenede Stater, 62269
- Memorial Hospital East
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Springfield, Illinois, Forenede Stater, 62781
- Memorial Medical Center
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Springfield, Illinois, Forenede Stater, 62702
- Southern Illinois University School of Medicine
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Springfield, Illinois, Forenede Stater, 62702
- Springfield Clinic
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Swansea, Illinois, Forenede Stater, 62226
- Southwest Illinois Health Services LLP
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Urbana, Illinois, Forenede Stater, 61801
- Carle Cancer Center
-
Urbana, Illinois, Forenede Stater, 61801
- The Carle Foundation Hospital
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Warrenville, Illinois, Forenede Stater, 60555
- Northwestern Medicine Cancer Center Warrenville
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Washington, Illinois, Forenede Stater, 61571
- Illinois CancerCare - Washington
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Yorkville, Illinois, Forenede Stater, 60560
- Rush-Copley Healthcare Center
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Indiana
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Crown Point, Indiana, Forenede Stater, 46307
- Northwest Cancer Center - Main Campus
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Dyer, Indiana, Forenede Stater, 46311
- Northwest Oncology LLC
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Hobart, Indiana, Forenede Stater, 46342
- Northwest Cancer Center - Hobart
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Hobart, Indiana, Forenede Stater, 46342
- Saint Mary Medical Center
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Indianapolis, Indiana, Forenede Stater, 46312
- Saint Catherine Hospital
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Munster, Indiana, Forenede Stater, 46321
- The Community Hospital
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Munster, Indiana, Forenede Stater, 46321
- Women's Diagnostic Center - Munster
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Richmond, Indiana, Forenede Stater, 47374
- Reid Health
-
South Bend, Indiana, Forenede Stater, 46601
- Memorial Hospital of South Bend
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Valparaiso, Indiana, Forenede Stater, 46383
- Northwest Cancer Center - Valparaiso
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Iowa
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Ames, Iowa, Forenede Stater, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Forenede Stater, 50010
- McFarland Clinic - Ames
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Ankeny, Iowa, Forenede Stater, 50023
- Mission Cancer and Blood - Ankeny
-
Boone, Iowa, Forenede Stater, 50036
- McFarland Clinic - Boone
-
Carroll, Iowa, Forenede Stater, 51401
- Saint Anthony Regional Hospital
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Oncology Associates at Mercy Medical Center
-
Cedar Rapids, Iowa, Forenede Stater, 52402
- Physicians' Clinic of Iowa PC
-
Clive, Iowa, Forenede Stater, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Forenede Stater, 50325
- Mission Cancer and Blood - West Des Moines
-
Council Bluffs, Iowa, Forenede Stater, 51503
- Alegent Health Mercy Hospital
-
Council Bluffs, Iowa, Forenede Stater, 51503
- Heartland Oncology and Hematology LLP
-
Council Bluffs, Iowa, Forenede Stater, 51503
- Methodist Jennie Edmundson Hospital
-
Creston, Iowa, Forenede Stater, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, Forenede Stater, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Forenede Stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forenede Stater, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, Forenede Stater, 50314
- Mission Cancer and Blood - Laurel
-
Des Moines, Iowa, Forenede Stater, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Forenede Stater, 50309
- Mission Cancer and Blood - Des Moines
-
Fort Dodge, Iowa, Forenede Stater, 50501
- Trinity Regional Medical Center
-
Fort Dodge, Iowa, Forenede Stater, 50501
- McFarland Clinic - Trinity Cancer Center
-
Jefferson, Iowa, Forenede Stater, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Forenede Stater, 50158
- McFarland Clinic - Marshalltown
-
West Des Moines, Iowa, Forenede Stater, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Forenede Stater, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, Forenede Stater, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, Forenede Stater, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Forenede Stater, 67042
- Cancer Center of Kansas - El Dorado
-
Garden City, Kansas, Forenede Stater, 67846
- Central Care Cancer Center - Garden City
-
Great Bend, Kansas, Forenede Stater, 67530
- Central Care Cancer Center - Great Bend
-
Hays, Kansas, Forenede Stater, 67601
- HaysMed
-
Independence, Kansas, Forenede Stater, 67301
- Cancer Center of Kansas-Independence
-
Kingman, Kansas, Forenede Stater, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Forenede Stater, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, Forenede Stater, 67905
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, Forenede Stater, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, Forenede Stater, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, Forenede Stater, 67114
- Cancer Center of Kansas - Newton
-
Olathe, Kansas, Forenede Stater, 66061
- Olathe Health Cancer Center
-
Parsons, Kansas, Forenede Stater, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, Forenede Stater, 66762
- Ascension Via Christi - Pittsburg
-
Pittsburg, Kansas, Forenede Stater, 66762
- Freeman Physician Group of Pittsburg
-
Pratt, Kansas, Forenede Stater, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Forenede Stater, 67401
- Salina Regional Health Center
-
Salina, Kansas, Forenede Stater, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, Forenede Stater, 66606
- University of Kansas Health System Saint Francis Campus
-
Wellington, Kansas, Forenede Stater, 67152
- Cancer Center of Kansas - Wellington
-
Wichita, Kansas, Forenede Stater, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Forenede Stater, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Forenede Stater, 67214
- Cancer Center of Kansas - Wichita
-
Winfield, Kansas, Forenede Stater, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Bardstown, Kentucky, Forenede Stater, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, Forenede Stater, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, Forenede Stater, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Forenede Stater, 40509
- Saint Joseph Hospital East
-
Lexington, Kentucky, Forenede Stater, 40504
- Saint Joseph Hospital
-
London, Kentucky, Forenede Stater, 40741
- Saint Joseph London
-
Louisville, Kentucky, Forenede Stater, 40202
- Jewish Hospital
-
Louisville, Kentucky, Forenede Stater, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Forenede Stater, 40215
- Saints Mary and Elizabeth Hospital
-
Mount Sterling, Kentucky, Forenede Stater, 40353
- Saint Joseph Mount Sterling
-
Shepherdsville, Kentucky, Forenede Stater, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Forenede Stater, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, Forenede Stater, 70816
- Medical Center of Baton Rouge
-
Baton Rouge, Louisiana, Forenede Stater, 70836
- Ochsner High Grove
-
Baton Rouge, Louisiana, Forenede Stater, 70808
- Our Lady of The Lake
-
Baton Rouge, Louisiana, Forenede Stater, 70808
- Our Lady of the Lake Physician Group
-
Covington, Louisiana, Forenede Stater, 70433
- Northshore Oncology Associates-Covington
-
Covington, Louisiana, Forenede Stater, 70433
- Ochsner Hematology Oncology North Shore - Covington (West Region)
-
Houma, Louisiana, Forenede Stater, 70360
- Terrebonne General Medical Center
-
Kenner, Louisiana, Forenede Stater, 70065
- Ochsner Medical Center Kenner
-
New Orleans, Louisiana, Forenede Stater, 70121
- Ochsner Medical Center Jefferson
-
Shreveport, Louisiana, Forenede Stater, 71103
- LSU Health Sciences Center at Shreveport
-
-
Maine
-
Augusta, Maine, Forenede Stater, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, Forenede Stater, 04401
- Eastern Maine Medical Center
-
Belfast, Maine, Forenede Stater, 04915
- Waldo County General Hospital
-
Biddeford, Maine, Forenede Stater, 04005
- MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
-
Brewer, Maine, Forenede Stater, 04412
- Lafayette Family Cancer Center-EMMC
-
Rockport, Maine, Forenede Stater, 04856
- Penobscot Bay Medical Center
-
Sanford, Maine, Forenede Stater, 04073
- MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
-
South Portland, Maine, Forenede Stater, 04106
- Maine Medical Partners - South Portland
-
-
Maryland
-
Aberdeen, Maryland, Forenede Stater, 21001
- UM Upper Chesapeake Hematology and Oncology - Aberdeen
-
Baltimore, Maryland, Forenede Stater, 21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
-
Baltimore, Maryland, Forenede Stater, 21204
- Greater Baltimore Medical Center
-
Baltimore, Maryland, Forenede Stater, 21244
- Kaiser Permanente-Woodlawn Medical Center
-
Baltimore, Maryland, Forenede Stater, 21239
- MedStar Good Samaritan Hospital
-
Bel Air, Maryland, Forenede Stater, 21014
- UM Upper Chesapeake Medical Center
-
Easton, Maryland, Forenede Stater, 21601
- University of Maryland Shore Medical Center at Easton
-
Elkton, Maryland, Forenede Stater, 21921
- Christiana Care - Union Hospital
-
Gaithersburg, Maryland, Forenede Stater, 20879
- Kaiser Permanente-Gaithersburg Medical Center
-
Kensington, Maryland, Forenede Stater, 20895
- Kaiser Permanente - Kensington Medical Center
-
Largo, Maryland, Forenede Stater, 20774
- Kaiser Permanente - Largo Medical Center
-
Lutherville, Maryland, Forenede Stater, 21093
- Kaiser Permanente Lutherville - Timonium Medical Center
-
-
Massachusetts
-
Boston, Massachusetts, Forenede Stater, 02111
- Tufts Medical Center
-
Plymouth, Massachusetts, Forenede Stater, 02360
- Beth Israel Deaconess Hospital-Plymouth
-
Springfield, Massachusetts, Forenede Stater, 01104
- Mercy Medical Center
-
-
Michigan
-
Ann Arbor, Michigan, Forenede Stater, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, Forenede Stater, 49017
- Bronson Battle Creek
-
Brighton, Michigan, Forenede Stater, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, Forenede Stater, 48114
- Trinity Health Medical Center - Brighton
-
Canton, Michigan, Forenede Stater, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, Forenede Stater, 48188
- Trinity Health Medical Center - Canton
-
Caro, Michigan, Forenede Stater, 48723
- Caro Cancer Center
-
Chelsea, Michigan, Forenede Stater, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, Forenede Stater, 48118
- Chelsea Hospital
-
Clarkston, Michigan, Forenede Stater, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, Forenede Stater, 48346
- Newland Medical Associates-Clarkston
-
Dearborn, Michigan, Forenede Stater, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, Forenede Stater, 48236
- Ascension Saint John Hospital
-
East China Township, Michigan, Forenede Stater, 48054
- Great Lakes Cancer Management Specialists-Doctors Park
-
Farmington Hills, Michigan, Forenede Stater, 48336
- Corewell Health Farmington Hills Hospital
-
Flint, Michigan, Forenede Stater, 48503
- Hurley Medical Center
-
Flint, Michigan, Forenede Stater, 48503
- Genesee Cancer and Blood Disease Treatment Center
-
Flint, Michigan, Forenede Stater, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, Forenede Stater, 48503
- Genesys Hurley Cancer Institute
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
-
Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Academic Hematology Oncology Specialists
-
Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
-
Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Michigan Breast Specialists-Grosse Pointe Woods
-
Kalamazoo, Michigan, Forenede Stater, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Forenede Stater, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Forenede Stater, 49048
- Borgess Medical Center
-
Kalamazoo, Michigan, Forenede Stater, 49009
- Ascension Borgess Cancer Center
-
Lansing, Michigan, Forenede Stater, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Forenede Stater, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, Forenede Stater, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, Forenede Stater, 48044
- Great Lakes Cancer Management Specialists-Macomb Medical Campus
-
Macomb, Michigan, Forenede Stater, 48044
- Michigan Breast Specialists-Macomb Township
-
Marlette, Michigan, Forenede Stater, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Muskegon, Michigan, Forenede Stater, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, Forenede Stater, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Norton Shores, Michigan, Forenede Stater, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Pontiac, Michigan, Forenede Stater, 48341
- Hope Cancer Center
-
Pontiac, Michigan, Forenede Stater, 48341
- Newland Medical Associates-Pontiac
-
Pontiac, Michigan, Forenede Stater, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Pontiac, Michigan, Forenede Stater, 48341
- Michigan Healthcare Professionals Pontiac
-
Reed City, Michigan, Forenede Stater, 49677
- Corewell Health Reed City Hospital
-
Rochester Hills, Michigan, Forenede Stater, 48309
- Great Lakes Cancer Management Specialists-Rochester Hills
-
Royal Oak, Michigan, Forenede Stater, 48073
- Cancer Care Associates PC
-
Royal Oak, Michigan, Forenede Stater, 48073
- Comprehensive Medical Center PLLC
-
Royal Oak, Michigan, Forenede Stater, 48073
- Hematology Oncology Consultants PC
-
Royal Oak, Michigan, Forenede Stater, 48073
- Oakland Medical Group
-
Royal Oak, Michigan, Forenede Stater, 48067
- Oakland Colon Rectal Associates
-
Royal Oak, Michigan, Forenede Stater, 48073
- Corewell Health William Beaumont University Hospital
-
Saginaw, Michigan, Forenede Stater, 48601
- Ascension Saint Mary's Hospital
-
Saginaw, Michigan, Forenede Stater, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saginaw, Michigan, Forenede Stater, 48604
- Covenant HealthCare Mackinaw
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Sterling Heights, Michigan, Forenede Stater, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Sterling Heights, Michigan, Forenede Stater, 48312
- Premier Hematology Oncology Care
-
Tawas City, Michigan, Forenede Stater, 48764
- Ascension Saint Joseph Hospital
-
Traverse City, Michigan, Forenede Stater, 49684
- Munson Medical Center
-
Troy, Michigan, Forenede Stater, 48084
- Michigan Institute of Urology-Town Center
-
Troy, Michigan, Forenede Stater, 48098
- Hematology Oncology Consultants PC-Troy
-
Troy, Michigan, Forenede Stater, 48085
- Corewell Health Beaumont Troy Hospital
-
Warren, Michigan, Forenede Stater, 48093
- Saint John Macomb-Oakland Hospital
-
Warren, Michigan, Forenede Stater, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, Forenede Stater, 48093
- Great Lakes Cancer Management Specialists-Macomb Professional Building
-
Warren, Michigan, Forenede Stater, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, Forenede Stater, 48093
- Michigan Breast Specialists-Warren
-
West Branch, Michigan, Forenede Stater, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyoming, Michigan, Forenede Stater, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, Forenede Stater, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, Forenede Stater, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Bemidji, Minnesota, Forenede Stater, 56601
- Sanford Joe Lueken Cancer Center
-
Burnsville, Minnesota, Forenede Stater, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, Forenede Stater, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, Forenede Stater, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, Forenede Stater, 55433
- Mercy Hospital
-
Edina, Minnesota, Forenede Stater, 55435
- Fairview Southdale Hospital
-
Fridley, Minnesota, Forenede Stater, 55432
- Unity Hospital
-
Mankato, Minnesota, Forenede Stater, 56001
- Mayo Clinic Health Systems-Mankato
-
Maple Grove, Minnesota, Forenede Stater, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Forenede Stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forenede Stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forenede Stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Forenede Stater, 55454
- Health Partners Inc
-
Minneapolis, Minnesota, Forenede Stater, 55417
- Minneapolis VA Medical Center
-
Monticello, Minnesota, Forenede Stater, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, Forenede Stater, 56073
- New Ulm Medical Center
-
Princeton, Minnesota, Forenede Stater, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, Forenede Stater, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Forenede Stater, 55905
- Mayo Clinic in Rochester
-
Saint Cloud, Minnesota, Forenede Stater, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Forenede Stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forenede Stater, 55102
- United Hospital
-
Shakopee, Minnesota, Forenede Stater, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Forenede Stater, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, Forenede Stater, 56701
- Sanford Thief River Falls Medical Center
-
Waconia, Minnesota, Forenede Stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forenede Stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forenede Stater, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, Forenede Stater, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, Forenede Stater, 55092
- Fairview Lakes Medical Center
-
-
Missouri
-
Ballwin, Missouri, Forenede Stater, 63011
- Saint Louis Cancer and Breast Institute-Ballwin
-
Bolivar, Missouri, Forenede Stater, 65613
- Central Care Cancer Center - Bolivar
-
Branson, Missouri, Forenede Stater, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Southeast Cancer Center
-
City of Saint Peters, Missouri, Forenede Stater, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Creve Coeur, Missouri, Forenede Stater, 63141
- Siteman Cancer Center at West County Hospital
-
Farmington, Missouri, Forenede Stater, 63640
- Parkland Health Center - Farmington
-
Jefferson City, Missouri, Forenede Stater, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Forenede Stater, 64804
- Freeman Health System
-
Joplin, Missouri, Forenede Stater, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, Forenede Stater, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, Forenede Stater, 64108
- University Health Truman Medical Center
-
Lee's Summit, Missouri, Forenede Stater, 64086
- Saint Luke's East - Lee's Summit
-
Osage Beach, Missouri, Forenede Stater, 65065
- Lake Regional Hospital
-
Rolla, Missouri, Forenede Stater, 65401
- Delbert Day Cancer Institute at PCRMC
-
Rolla, Missouri, Forenede Stater, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Saint Joseph, Missouri, Forenede Stater, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, Forenede Stater, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Forenede Stater, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Forenede Stater, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Forenede Stater, 63110
- Washington University School of Medicine
-
St Louis, Missouri, Forenede Stater, 63129
- Siteman Cancer Center-South County
-
St Louis, Missouri, Forenede Stater, 63136
- Siteman Cancer Center at Christian Hospital
-
St Louis, Missouri, Forenede Stater, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Forenede Stater, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, Forenede Stater, 63128
- Mercy Hospital South
-
St Louis, Missouri, Forenede Stater, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Sullivan, Missouri, Forenede Stater, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, Forenede Stater, 63127
- BJC Outpatient Center at Sunset Hills
-
Washington, Missouri, Forenede Stater, 63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda, Montana, Forenede Stater, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Forenede Stater, 59101
- Billings Clinic Cancer Center
-
Bozeman, Montana, Forenede Stater, 59715
- Bozeman Health Deaconess Hospital
-
Great Falls, Montana, Forenede Stater, 59405
- Great Falls Clinic
-
Great Falls, Montana, Forenede Stater, 59405
- Benefis Sletten Cancer Institute
-
Kalispell, Montana, Forenede Stater, 59901
- Kalispell Regional Medical Center
-
Missoula, Montana, Forenede Stater, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Forenede Stater, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, Forenede Stater, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Forenede Stater, 68847
- CHI Health Good Samaritan
-
Lincoln, Nebraska, Forenede Stater, 68510
- Saint Elizabeth Regional Medical Center
-
Lincoln, Nebraska, Forenede Stater, 68516
- Cancer Partners of Nebraska - Pine Lake
-
Lincoln, Nebraska, Forenede Stater, 68516
- Cancer Partners of Nebraska
-
Omaha, Nebraska, Forenede Stater, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, Forenede Stater, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Forenede Stater, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Forenede Stater, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Forenede Stater, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, Forenede Stater, 68114
- Oncology Associates PC
-
Omaha, Nebraska, Forenede Stater, 68114
- Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
-
Papillion, Nebraska, Forenede Stater, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, Forenede Stater, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, Forenede Stater, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- OptumCare Cancer Care at Seven Hills
-
Henderson, Nevada, Forenede Stater, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Forenede Stater, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Forenede Stater, 89074
- GenesisCare USA - Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, Forenede Stater, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, Forenede Stater, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, Forenede Stater, 89074
- Urology Specialists of Nevada - Green Valley
-
Las Vegas, Nevada, Forenede Stater, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Forenede Stater, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Forenede Stater, 89109
- GenesisCare USA - Las Vegas
-
Las Vegas, Nevada, Forenede Stater, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Forenede Stater, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Forenede Stater, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Forenede Stater, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Forenede Stater, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Forenede Stater, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Forenede Stater, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Forenede Stater, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, Forenede Stater, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Forenede Stater, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Forenede Stater, 89128
- GenesisCare USA - Vegas Tenaya
-
Las Vegas, Nevada, Forenede Stater, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89148
- GenesisCare USA - Fort Apache
-
Las Vegas, Nevada, Forenede Stater, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, Forenede Stater, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, Forenede Stater, 89102
- Desert West Surgery
-
Las Vegas, Nevada, Forenede Stater, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, Forenede Stater, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, Forenede Stater, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, Forenede Stater, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, Forenede Stater, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, Forenede Stater, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, Forenede Stater, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, Forenede Stater, 89169
- University Cancer Center
-
Las Vegas, Nevada, Forenede Stater, 89113
- Urology Specialists of Nevada - Southwest
-
Pahrump, Nevada, Forenede Stater, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, Forenede Stater, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Forenede Stater, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Forenede Stater, 89509
- Radiation Oncology Associates
-
-
New Jersey
-
Englewood, New Jersey, Forenede Stater, 07631
- Englewood Hospital and Medical Center
-
Mullica Hill, New Jersey, Forenede Stater, 08062
- Inspira Medical Center Mullica Hill
-
Paramus, New Jersey, Forenede Stater, 07652
- The Valley Hospital - Luckow Pavilion
-
Ridgewood, New Jersey, Forenede Stater, 07450
- Neurosurgeons of New Jersey-Ridgewood
-
Ridgewood, New Jersey, Forenede Stater, 07450
- Valley Health System Ridgewood Campus
-
Teaneck, New Jersey, Forenede Stater, 07666
- Holy Name Hospital
-
Westwood, New Jersey, Forenede Stater, 07675
- Valley Health System-Hematology/Oncology
-
-
New Mexico
-
Albuquerque, New Mexico, Forenede Stater, 87106
- University of New Mexico Cancer Center
-
-
New York
-
Auburn, New York, Forenede Stater, 13021
- Hematology Oncology Associates of Central New York-Auburn
-
Cooperstown, New York, Forenede Stater, 13326
- Mary Imogene Bassett Hospital
-
East Syracuse, New York, Forenede Stater, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Glens Falls, New York, Forenede Stater, 12801
- Glens Falls Hospital
-
New York, New York, Forenede Stater, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
Nyack, New York, Forenede Stater, 10960
- Nyack Hospital
-
Syracuse, New York, Forenede Stater, 13215
- Hematology Oncology Associates of Central New York-Onondaga Hill
-
The Bronx, New York, Forenede Stater, 10461
- Montefiore Medical Center-Einstein Campus
-
The Bronx, New York, Forenede Stater, 10467
- Montefiore Medical Center - Moses Campus
-
The Bronx, New York, Forenede Stater, 10461
- Montefiore Medical Center-Weiler Hospital
-
-
North Carolina
-
Asheville, North Carolina, Forenede Stater, 28803
- AdventHealth Infusion Center Asheville
-
Clinton, North Carolina, Forenede Stater, 28328
- Southeastern Medical Oncology Center-Clinton
-
Clyde, North Carolina, Forenede Stater, 28721
- AdventHealth Infusion Center Haywood
-
Goldsboro, North Carolina, Forenede Stater, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Hendersonville, North Carolina, Forenede Stater, 28791
- Margaret R Pardee Memorial Hospital
-
Hendersonville, North Carolina, Forenede Stater, 28792
- AdventHealth Hendersonville
-
Jacksonville, North Carolina, Forenede Stater, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Washington, North Carolina, Forenede Stater, 27889
- Marion L Shepard Cancer Center - ECU Health Beaufort Hospital
-
Weaverville, North Carolina, Forenede Stater, 28787
- AdventHealth Infusion Center Weaverville
-
-
North Dakota
-
Bismarck, North Dakota, Forenede Stater, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, Forenede Stater, 58103
- Sanford South University Medical Center
-
Fargo, North Dakota, Forenede Stater, 58103
- Southpointe-Sanford Medical Center Fargo
-
Fargo, North Dakota, Forenede Stater, 58104
- Sanford Medical Center Fargo
-
Grand Forks, North Dakota, Forenede Stater, 58201
- Altru Cancer Center
-
-
Ohio
-
Akron, Ohio, Forenede Stater, 44307
- Cleveland Clinic Akron General
-
Alliance, Ohio, Forenede Stater, 44601
- Aultman Alliance Community Hospital
-
Beavercreek, Ohio, Forenede Stater, 45431
- Indu and Raj Soin Medical Center
-
Boardman, Ohio, Forenede Stater, 44512
- Saint Elizabeth Boardman Hospital
-
Canton, Ohio, Forenede Stater, 44710
- Aultman Health Foundation
-
Centerville, Ohio, Forenede Stater, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Forenede Stater, 45459
- Dayton Physicians LLC-Miami Valley South
-
Cincinnati, Ohio, Forenede Stater, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Forenede Stater, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Forenede Stater, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Forenede Stater, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, Forenede Stater, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Forenede Stater, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Forenede Stater, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Dayton, Ohio, Forenede Stater, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Forenede Stater, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Forenede Stater, 45415
- Dayton Physician LLC - Englewood
-
Findlay, Ohio, Forenede Stater, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Forenede Stater, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Forenede Stater, 45840
- Orion Cancer Care
-
Franklin, Ohio, Forenede Stater, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Forenede Stater, 45005
- Dayton Physicians LLC-Atrium
-
Greenville, Ohio, Forenede Stater, 45331
- Wayne Hospital
-
Greenville, Ohio, Forenede Stater, 45331
- Dayton Physicians LLC-Wayne
-
Independence, Ohio, Forenede Stater, 44131
- Cleveland Clinic Cancer Center Independence
-
Kettering, Ohio, Forenede Stater, 45429
- Kettering Medical Center
-
Kettering, Ohio, Forenede Stater, 45409
- Greater Dayton Cancer Center
-
Kettering, Ohio, Forenede Stater, 45420
- First Dayton Cancer Care
-
Mansfield, Ohio, Forenede Stater, 44906
- Cleveland Clinic Cancer Center Mansfield
-
Mayfield Heights, Ohio, Forenede Stater, 44124
- Hillcrest Hospital Cancer Center
-
Sandusky, Ohio, Forenede Stater, 44870
- North Coast Cancer Care
-
Springfield, Ohio, Forenede Stater, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Forenede Stater, 45504
- Springfield Regional Medical Center
-
Steubenville, Ohio, Forenede Stater, 43952
- Trinity's Tony Teramana Cancer Center
-
Strongsville, Ohio, Forenede Stater, 44136
- Cleveland Clinic Cancer Center Strongsville
-
Sylvania, Ohio, Forenede Stater, 43560
- ProMedica Flower Hospital
-
Toledo, Ohio, Forenede Stater, 43606
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
-
Troy, Ohio, Forenede Stater, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Forenede Stater, 45373
- Dayton Physicians LLC - Troy
-
Warren, Ohio, Forenede Stater, 44484
- Saint Joseph Warren Hospital
-
Warrensville Heights, Ohio, Forenede Stater, 44122
- South Pointe Hospital
-
West Chester, Ohio, Forenede Stater, 45069
- University of Cincinnati Cancer Center-West Chester
-
Wooster, Ohio, Forenede Stater, 44691
- Cleveland Clinic Wooster Family Health and Surgery Center
-
Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433
- Wright-Patterson Medical Center
-
Youngstown, Ohio, Forenede Stater, 44501
- Saint Elizabeth Youngstown Hospital
-
-
Oklahoma
-
Lawton, Oklahoma, Forenede Stater, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Forenede Stater, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Forenede Stater, 73120
- Mercy Hospital Oklahoma City
-
Oklahoma City, Oklahoma, Forenede Stater, 73109
- Integris Southwest Medical Center
-
Oklahoma City, Oklahoma, Forenede Stater, 73142
- Integris Cancer Institute of Oklahoma
-
-
Oregon
-
Baker City, Oregon, Forenede Stater, 97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Bend, Oregon, Forenede Stater, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Forenede Stater, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Forenede Stater, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Forenede Stater, 97420
- Bay Area Hospital
-
Newberg, Oregon, Forenede Stater, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Forenede Stater, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Oregon City, Oregon, Forenede Stater, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, Forenede Stater, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Forenede Stater, 97225
- Providence Saint Vincent Medical Center
-
Redmond, Oregon, Forenede Stater, 97756
- Saint Charles Health System-Redmond
-
-
Pennsylvania
-
Allentown, Pennsylvania, Forenede Stater, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Altoona, Pennsylvania, Forenede Stater, 16601
- UPMC Altoona
-
Beaver, Pennsylvania, Forenede Stater, 15009
- UPMC-Heritage Valley Health System Beaver
-
Bethlehem, Pennsylvania, Forenede Stater, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Butler, Pennsylvania, Forenede Stater, 16001
- UPMC Hillman Cancer Center at Butler Health System
-
Camp Hill, Pennsylvania, Forenede Stater, 17011
- UPMC Camp Hill
-
Carlisle, Pennsylvania, Forenede Stater, 17015
- Carlisle Regional Cancer Center
-
Chadds Ford, Pennsylvania, Forenede Stater, 19317
- Christiana Care Health System-Concord Health Center
-
Coudersport, Pennsylvania, Forenede Stater, 16915
- Patterson Cancer Center at UPMC Cole
-
Danville, Pennsylvania, Forenede Stater, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, Forenede Stater, 18301
- Pocono Medical Center
-
Erie, Pennsylvania, Forenede Stater, 16505
- UPMC Hillman Cancer Center Erie
-
Farrell, Pennsylvania, Forenede Stater, 16121
- UPMC Cancer Center at UPMC Horizon
-
Greensburg, Pennsylvania, Forenede Stater, 15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Greenville, Pennsylvania, Forenede Stater, 16125
- Oncology Hematology Associates
-
Greenville, Pennsylvania, Forenede Stater, 16125
- UPMC Hillman Cancer Center in Greenville/UPMC Horizon
-
Harrisburg, Pennsylvania, Forenede Stater, 17109
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Harrisburg, Pennsylvania, Forenede Stater, 17101
- UPMC Pinnacle Harrisburg
-
Hazleton, Pennsylvania, Forenede Stater, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, Forenede Stater, 18201
- Lehigh Valley Hospital-Hazleton
-
Indiana, Pennsylvania, Forenede Stater, 15701
- IRMC Cancer Center
-
Johnstown, Pennsylvania, Forenede Stater, 15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lewisburg, Pennsylvania, Forenede Stater, 17837
- Geisinger Medical Oncology-Lewisburg
-
McKeesport, Pennsylvania, Forenede Stater, 15132
- UPMC Cancer Center at UPMC McKeesport
-
Mechanicsburg, Pennsylvania, Forenede Stater, 17050
- UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
-
Monroeville, Pennsylvania, Forenede Stater, 15146
- UPMC Hillman Cancer Center - Monroeville
-
Moon Township, Pennsylvania, Forenede Stater, 15108
- UPMC Hillman Cancer Center in Coraopolis
-
Mount Pleasant, Pennsylvania, Forenede Stater, 15666
- UPMC Hillman Cancer Center - Part of Frick Hospital
-
N. Huntingdon, Pennsylvania, Forenede Stater, 15642
- Arnold Palmer Cancer Center Medical Oncology Norwin
-
Natrona Heights, Pennsylvania, Forenede Stater, 15065
- UPMC Cancer Center-Natrona Heights
-
New Castle, Pennsylvania, Forenede Stater, 16105
- UPMC Hillman Cancer Center - New Castle
-
Pittsburgh, Pennsylvania, Forenede Stater, 15232
- University of Pittsburgh Cancer Institute (UPCI)
-
Pittsburgh, Pennsylvania, Forenede Stater, 15215
- UPMC-Saint Margaret
-
Pittsburgh, Pennsylvania, Forenede Stater, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pittsburgh, Pennsylvania, Forenede Stater, 15219
- UPMC-Mercy Hospital
-
Pottsville, Pennsylvania, Forenede Stater, 17901
- Geisinger Cancer Services-Pottsville
-
Sayre, Pennsylvania, Forenede Stater, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
Scranton, Pennsylvania, Forenede Stater, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, Forenede Stater, 17870
- Geisinger Medical Oncology-Selinsgrove
-
Seneca, Pennsylvania, Forenede Stater, 16346
- UPMC Cancer Center at UPMC Northwest
-
Uniontown, Pennsylvania, Forenede Stater, 15401
- UPMC Cancer Center-Uniontown
-
Washington, Pennsylvania, Forenede Stater, 15301
- UPMC Cancer Center-Washington
-
West Mifflin, Pennsylvania, Forenede Stater, 15122
- UPMC West Mifflin-Cancer Center Jefferson
-
Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport, Pennsylvania, Forenede Stater, 17754
- Divine Providence Hospital
-
Willow Grove, Pennsylvania, Forenede Stater, 19090
- Asplundh Cancer Pavilion
-
York, Pennsylvania, Forenede Stater, 17408
- UPMC Memorial
-
-
South Carolina
-
Beaufort, South Carolina, Forenede Stater, 29902
- Beaufort Memorial Hospital
-
Boiling Springs, South Carolina, Forenede Stater, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, Forenede Stater, 29425
- Medical University of South Carolina
-
Easley, South Carolina, Forenede Stater, 29640
- Prisma Health Cancer Institute - Easley
-
Georgetown, South Carolina, Forenede Stater, 29440
- Tidelands Georgetown Memorial Hospital
-
Greenville, South Carolina, Forenede Stater, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Forenede Stater, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Forenede Stater, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenwood, South Carolina, Forenede Stater, 29646
- Self Regional Healthcare
-
Greer, South Carolina, Forenede Stater, 29650
- Prisma Health Cancer Institute - Greer
-
Seneca, South Carolina, Forenede Stater, 29672
- Prisma Health Cancer Institute - Seneca
-
-
South Dakota
-
Aberdeen, South Dakota, Forenede Stater, 57401
- Avera Cancer Institute-Aberdeen
-
Sioux Falls, South Dakota, Forenede Stater, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Forenede Stater, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Forenede Stater, 57104
- Sanford Cancer Center Oncology Clinic
-
Yankton, South Dakota, Forenede Stater, 57078
- Avera Cancer Institute at Yankton
-
-
Tennessee
-
Bristol, Tennessee, Forenede Stater, 37620
- Bristol Regional Medical Center
-
Cookeville, Tennessee, Forenede Stater, 38501
- Cookeville Regional Medical Center
-
Kingsport, Tennessee, Forenede Stater, 37660
- Ballad Health Cancer Care - Kingsport
-
Kingsport, Tennessee, Forenede Stater, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
-
Texas
-
Austin, Texas, Forenede Stater, 78712
- University of Texas at Austin
-
Austin, Texas, Forenede Stater, 78701
- Dell Seton Medical Center at The University of Texas
-
Bryan, Texas, Forenede Stater, 77802
- Saint Joseph Regional Cancer Center
-
Houston, Texas, Forenede Stater, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Houston, Texas, Forenede Stater, 77030
- Michael E DeBakey VA Medical Center
-
Houston, Texas, Forenede Stater, 77030
- Ben Taub General Hospital
-
-
Vermont
-
Berlin Corners, Vermont, Forenede Stater, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Forenede Stater, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Forenede Stater, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Bristol, Virginia, Forenede Stater, 24201
- Wellmont Medical Associates-Bristol
-
Burke, Virginia, Forenede Stater, 22015
- Kaiser Permanente-Burke Medical Center
-
Fairfax, Virginia, Forenede Stater, 22031
- Inova Schar Cancer Institute
-
Fairfax, Virginia, Forenede Stater, 22033
- Inova Fair Oaks Hospital
-
Falls Church, Virginia, Forenede Stater, 22042
- Inova Fairfax Hospital
-
Lynchburg, Virginia, Forenede Stater, 24501
- Centra Alan B Pearson Regional Cancer Center
-
Martinsville, Virginia, Forenede Stater, 24112
- Sovah Health Martinsville
-
McLean, Virginia, Forenede Stater, 22102
- Kaiser Permanente Tysons Corner Medical Center
-
Mechanicsville, Virginia, Forenede Stater, 23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian, Virginia, Forenede Stater, 23114
- Bon Secours Saint Francis Medical Center
-
Midlothian, Virginia, Forenede Stater, 23113
- Bon Secours Westchester Emergency Center
-
Norfolk, Virginia, Forenede Stater, 23505
- Bon Secours DePaul Medical Center
-
Norton, Virginia, Forenede Stater, 24273
- Southwest VA Regional Cancer Center
-
Portsmouth, Virginia, Forenede Stater, 23707
- Bon Secours Maryview Medical Center
-
Richmond, Virginia, Forenede Stater, 23235
- VCU Massey Cancer Center at Stony Point
-
Richmond, Virginia, Forenede Stater, 23298
- Virginia Commonwealth University/Massey Cancer Center
-
Richmond, Virginia, Forenede Stater, 23229
- Virginia Cancer Institute
-
Richmond, Virginia, Forenede Stater, 23226
- Bon Secours Saint Mary's Hospital
-
Richmond, Virginia, Forenede Stater, 23230
- Bon Secours Cancer Institute at Reynolds Crossing
-
Richmond, Virginia, Forenede Stater, 23223
- Bon Secours Richmond Community Hospital
-
South Hill, Virginia, Forenede Stater, 23970
- VCU Community Memorial Health Center
-
Suffolk, Virginia, Forenede Stater, 23435
- Bon Secours Health Center at Harbour View
-
Winchester, Virginia, Forenede Stater, 22601
- Shenandoah Oncology PC
-
Woodbridge, Virginia, Forenede Stater, 22192
- Kaiser Permanente-Caton Hill Medical Center
-
-
Washington
-
Aberdeen, Washington, Forenede Stater, 98520
- Providence Regional Cancer System-Aberdeen
-
Bellevue, Washington, Forenede Stater, 98004
- Overlake Medical Center
-
Bellingham, Washington, Forenede Stater, 98225
- PeaceHealth Saint Joseph Medical Center
-
Bremerton, Washington, Forenede Stater, 98310
- Harrison HealthPartners Hematology and Oncology-Bremerton
-
Burien, Washington, Forenede Stater, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, Forenede Stater, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Forenede Stater, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, Forenede Stater, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Forenede Stater, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Forenede Stater, 98003
- Saint Francis Hospital
-
Issaquah, Washington, Forenede Stater, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Forenede Stater, 99336
- Kadlec Clinic Hematology and Oncology
-
Lacey, Washington, Forenede Stater, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Forenede Stater, 98499
- Saint Clare Hospital
-
Longview, Washington, Forenede Stater, 98632
- PeaceHealth Saint John Medical Center
-
Mount Vernon, Washington, Forenede Stater, 98274
- Skagit Regional Health Cancer Care Center
-
Poulsbo, Washington, Forenede Stater, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Renton, Washington, Forenede Stater, 98055
- Valley Medical Center
-
Seattle, Washington, Forenede Stater, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Forenede Stater, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Forenede Stater, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, Forenede Stater, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Sedro-Woolley, Washington, Forenede Stater, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, Forenede Stater, 98584
- Providence Regional Cancer System-Shelton
-
Silverdale, Washington, Forenede Stater, 98383
- Saint Michael Cancer Center
-
Tacoma, Washington, Forenede Stater, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Forenede Stater, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, Forenede Stater, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Forenede Stater, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Forenede Stater, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, Forenede Stater, 98597
- Providence Regional Cancer System-Yelm
-
-
West Virginia
-
Bridgeport, West Virginia, Forenede Stater, 26330
- United Hospital Center
-
Martinsburg, West Virginia, Forenede Stater, 25401
- WVUH-Berkely Medical Center
-
Morgantown, West Virginia, Forenede Stater, 26506
- West Virginia University Healthcare
-
Parkersburg, West Virginia, Forenede Stater, 26101
- Camden Clark Medical Center
-
Princeton, West Virginia, Forenede Stater, 24740
- Princeton Community Hospital
-
Wheeling, West Virginia, Forenede Stater, 26003
- Wheeling Hospital/Schiffler Cancer Center
-
-
Wisconsin
-
Appleton, Wisconsin, Forenede Stater, 54911
- ThedaCare Regional Cancer Center
-
Appleton, Wisconsin, Forenede Stater, 54915
- Ascension Saint Elizabeth Hospital
-
Brookfield, Wisconsin, Forenede Stater, 53045
- Ascension Southeast Wisconsin Hospital - Elmbrook Campus
-
Chilton, Wisconsin, Forenede Stater, 53014
- Ascension Calumet Hospital
-
Chippewa Falls, Wisconsin, Forenede Stater, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- Mayo Clinic Health System-Eau Claire Clinic
-
Fond du Lac, Wisconsin, Forenede Stater, 54935
- Saint Agnes Hospital/Agnesian Cancer Center
-
Franklin, Wisconsin, Forenede Stater, 53132
- Ascension Saint Francis - Reiman Cancer Center
-
Franklin, Wisconsin, Forenede Stater, 53132
- Ascension Southeast Wisconsin Hospital - Franklin
-
Green Bay, Wisconsin, Forenede Stater, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Forenede Stater, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Ladysmith, Wisconsin, Forenede Stater, 54848
- Marshfield Medical Center - Ladysmith
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Medical Center-Marshfield
-
Menomonee Falls, Wisconsin, Forenede Stater, 53051
- Froedtert Menomonee Falls Hospital
-
Mequon, Wisconsin, Forenede Stater, 53097
- Ascension Columbia Saint Mary's Hospital Ozaukee
-
Milwaukee, Wisconsin, Forenede Stater, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Forenede Stater, 53211
- Ascension Columbia Saint Mary's Hospital - Milwaukee
-
Milwaukee, Wisconsin, Forenede Stater, 53215
- Ascension Saint Francis Hospital
-
Minocqua, Wisconsin, Forenede Stater, 54548
- Marshfield Clinic-Minocqua Center
-
Mukwonago, Wisconsin, Forenede Stater, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Forenede Stater, 54017
- Cancer Center of Western Wisconsin
-
Oak Creek, Wisconsin, Forenede Stater, 53154
- Drexel Town Square Health Center
-
Oconomowoc, Wisconsin, Forenede Stater, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, Forenede Stater, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, Forenede Stater, 54904
- Ascension Mercy Hospital
-
Oshkosh, Wisconsin, Forenede Stater, 54904
- ThedaCare Cancer Care - Oshkosh
-
Racine, Wisconsin, Forenede Stater, 53405
- Ascension All Saints Hospital
-
Rhinelander, Wisconsin, Forenede Stater, 54501
- Ascension Saint Mary's Hospital
-
Rice Lake, Wisconsin, Forenede Stater, 54868
- Marshfield Medical Center-Rice Lake
-
Stevens Point, Wisconsin, Forenede Stater, 54481
- Ascension Saint Michael's Hospital
-
Stevens Point, Wisconsin, Forenede Stater, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Waukesha, Wisconsin, Forenede Stater, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, Forenede Stater, 53188
- ProHealth Waukesha Memorial Hospital
-
Wausau, Wisconsin, Forenede Stater, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, Forenede Stater, 53226
- Ascension Medical Group Southeast Wisconsin - Mayfair Road
-
West Bend, Wisconsin, Forenede Stater, 53095
- Froedtert West Bend Hospital/Kraemer Cancer Center
-
Weston, Wisconsin, Forenede Stater, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Cody, Wyoming, Forenede Stater, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Forenede Stater, 82801
- Welch Cancer Center
-
-
-
-
-
Tamuning, Guam, 96913
- FHP Health Center-Guam
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
21 år og ældre (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Beskrivelse
- Stadie II-III kolorektal cancerpatienter, der er planlagt til at modtage oxaliplatin 510 mg/m^2 (kumulativ dosis) over 12 uger som en komponent af adjuverende leucovorin calcium (calciumfolinat), 5-fluorouracil og oxaliplatin (FOLFOX) behandling, hvor patienter er planlagt til at modtage oxaliplatin 85 mg/m^2 hver anden uge i 12 uger (dvs. 6 cyklusser) eller adjuverende capecitabin- og oxaliplatin- (CAPOX) behandling, hvor patienterne er planlagt til at modtage oxaliplatin 135 mg/m^2 hver 3. uge i 12 uger (dvs. 4 cyklusser)
- Ingen forudgående neurotoksisk kemoterapi
- Ingen allerede eksisterende klinisk eller præklinisk perifer neuropati af nogen årsag.
- Ingen historie med anfaldsforstyrrelse,
- Ingen historie med snævervinklet glaukom.
- Ingen symptomer på eller historie med skizofreni, bipolar sygdom, selvmordstanker og/eller en alvorlig depression.
- Ingen alvorlig spiseforstyrrelse som bulimi eller anoreksi.
- Ingen kendt diagnose af ethanol (ETOH) afhængighed/afhængighed inden for de seneste 10 år.
Samtidig medicin:
- Ingen samtidig brug af andre adjuverende farmakologiske indgreb (f.eks. gabapentin, pregabalin, venlafaxin) med kendt eller antaget effekt for perifer neuropati. Skal seponeres mindst 7 dage før start af protokolbehandling
- Ingen forventet eller samtidig brug af antidepressiva eller serotonin-ændrende midler, der vides at interagere med duloxetin, på grund af bekymring vedrørende kumulativ toksicitet og potentielle lægemiddelinteraktioner.
- Brug af en monoaminoxidasehæmmer (MAOI) eller andre antidepressiva skal seponeres mindst 14 dage før påbegyndelse af protokolbehandling.
- Ingen samtidig behandling med stærke CYP1A2- og CYP2D6-hæmmere.
- Kronisk samtidig behandling med lægemidler, der i vid udstrækning metaboliseres af CYP2D6, og som har et snævert terapeutisk indeks, herunder visse antidepressiva, phenothiaziner og type 1C antiarytmika, bør behandles med forsigtighed. Samtidig administration af duloxetin og thioridazin bør undgås.
- Ingen brug af warfarin eller heparinprodukter.
- Ikke gravid og ikke ammende, fordi denne undersøgelse involverer et forsøgsmiddel, hvis genotoksiske, mutagene og teratogene virkninger på det udviklende foster og nyfødte er ukendte. For kvinder i den fødedygtige alder kræves derfor en negativ graviditetstest udført =< 7 dage før registrering.
- Eastern Cooperative Oncology Group (ECOG) præstationsstatus 0-2
- For at gennemføre den obligatoriske patientgennemførte foranstaltning skal patienterne kunne tale og læse engelsk
- Beregnet kreatininclearance > 30 ml/min
- Aspartataminotransferaser (AST)/serumglutamin-oxaloeddikesyretransaminase (SGOT) =< 3 x øvre normalgrænse (ULN)
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Støttende pleje
- Tildeling: Randomiseret
- Interventionel model: Sekventiel tildeling
- Maskning: Dobbelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: Fase II, arm I (duloxetinhydrochlorid, placebo)
Patienter i fase II får duloxetinhydrochlorid 30 mg (1 duloxetinkapsel) oralt (PO) én gang dagligt (QD) i uge 1, duloxetinhydrochlorid 30 mg (1 duloxetinkapsel) PO QD og placebo (1 placebokapsel) PO QD i uge 2 -16, efterfulgt af duloxetinhydrochlorid 30 mg (1 duloxetinkapsel) PO QD i uge 17 i fravær af uacceptabel toksicitet.
|
Hjælpestudier
Givet PO
Hjælpestudier
Givet standardbehandling oxaliplatin
Givet PO
Givet PO
|
|
Eksperimentel: Fase II, arm II (duloxetinhydrochlorid)
Patienter i fase II får duloxetinhydrochlorid 30 mg (1 duloxetinkapsel) oralt (PO) én gang dagligt (QD) i uge 1, duloxetinhydrochlorid 60 mg (2 duloxetinkapsler) PO QD i uge 2-16, efterfulgt af duloxetinhydrochlorid 30 mg (1 duloxetin kapsel) PO QD i uge 17 i fravær af uacceptabel toksicitet.
|
Hjælpestudier
Hjælpestudier
Givet standardbehandling oxaliplatin
Givet PO
Givet PO
|
|
Placebo komparator: Fase II, arm III (placebo)
Patienter i fase II får placebo (1 placebo kapsel) oralt (PO) en gang dagligt (QD) i uge 1, placebo (2 placebo kapsler) PO QD uge 2-16, efterfulgt af placebo (1 placebo kapsel) PO QD i uge 17 i fravær af uacceptabel toksicitet.
|
Hjælpestudier
Givet PO
Hjælpestudier
Givet standardbehandling oxaliplatin
|
|
Eksperimentel: Fase III, arm I (duloxetinhydrochlorid)
Patienter i fase III modtager den mest lovende dosis af duloxetinhydrochlorid fra fase II PO QD i fravær af uacceptabel toksicitet.
|
Hjælpestudier
Hjælpestudier
Givet standardbehandling oxaliplatin
Givet PO
Givet PO
|
|
Placebo komparator: Fase III, arm II (placebo)
Patienter i fase III modtager placebo PO QD i fravær af uacceptabel toksicitet.
|
Hjælpestudier
Givet PO
Hjælpestudier
Givet standardbehandling oxaliplatin
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Forebyggelse af sensorisk oxaliplatin-induceret perifer neuropati (OIPN) respons (fase II)
Tidsramme: Op til 1 måned efter oxaliplatinbehandling
|
Vil blive målt ved hjælp af 6 individuelle livskvalitetsspørgeskema - Kemoterapi-induceret perifer neuropati 20 (QLQ-CIPN20) spørgsmål, der kvantificerer følelsesløshed, prikken og smerter i fingre (eller hænder) og tæer (eller fødder).
For hvert af de 6 individuelle spørgsmål bliver patienterne bedt om at vælge 1 ud af 4 valg vedrørende, hvordan hvert af de sensoriske symptomer havde påvirket dem i løbet af den foregående uge: 1 = Slet ikke, 2 = Lidt, 3 = Ganske lidt, og 4 = Rigtig meget.
Respons vil blive defineret som en patient, der rapporterer en højeste score på ≤ 2 på et hvilket som helst tidspunkt under oxaliplatin-eksponering, inklusive 1 måned post-oxaliplatin-behandling uden at afbryde undersøgelsen på grund af sensorisk oxaliplatin-induceret perifer neuropati.
Andelen af respondere inden for hver arm vil blive estimeret ved antallet af respondere divideret med det samlede antal evaluerbare patienter.
Tosidede 90 % nøjagtige konfidensintervaller for den sande responsandel vil blive beregnet i henhold til Cloppers og Pearsons tilgang.
|
Op til 1 måned efter oxaliplatinbehandling
|
|
Forebyggelse af sensorisk oxaliplatin-induceret perifer neuropati (OIPN) respons (fase III)
Tidsramme: Op til 1 måned efter oxaliplatinbehandling
|
Vil blive målt ved hjælp af 6 individuelle livskvalitetsspørgeskema - Kemoterapi-induceret perifer neuropati 20 (QLQ-CIPN20) spørgsmål, der kvantificerer følelsesløshed, prikken og smerter i de distale ekstremiteter.
For hvert af de 6 spørgsmål bliver patienter bedt om at vælge 1 ud af 4 valg vedrørende, hvordan hvert af de sensoriske symptomer havde påvirket dem i løbet af den foregående uge: 1=Slet ikke, 2=Lidt, 3=Ganske lidt og 4 = Rigtig meget.
Respons vil blive defineret som en patient, der rapporterer en højeste score på ≤ 2 på et hvilket som helst tidspunkt under oxaliplatineksponering, inklusive 1 måned post-oxaliplatinbehandling uden at afbryde undersøgelsen på grund af sensorisk OIPN.
Analysepopulationen er defineret som alle randomiserede patienter, der modtog mindst 1 dosis oxaliplatin og har afsluttet de 6 QLQCIPN20 sensoriske symptomelementer ved mindst 1 lejlighed under oxaliplatinbehandling, inklusive 1 måned post-oxaliplatinbehandling.
Fishers eksakte test vil blive brugt til en sammenligning mellem armene af andelen af respondere.
|
Op til 1 måned efter oxaliplatinbehandling
|
|
Kronisk neuropatisk smerterespons (fase III)
Tidsramme: Op til 1 måned efter behandling med oxaliplatin
|
Respons vil blive defineret som et 7-dages gennemsnit af kroniske neuropatiske smerter (i gennemsnit) ≤ 3 på en 0 (ingen smerte) til 10 (smerte så slemt, som du kan forestille dig) 1 måned efter oxaliplatin-behandling, som opnås fra 7-dages kronisk neuropati smertedagbog.
Analysepopulationen er defineret som alle randomiserede patienter, der fik mindst 1 dosis oxaliplatin og har afsluttet 7-dages kronisk neuropati smertedagbog på mindst 3 af de 7 dage 1 måned efter den sidste oxaliplatin-dosis.
Fishers eksakte test vil blive brugt til en sammenligning mellem armene af andelen af respondere.
|
Op til 1 måned efter behandling med oxaliplatin
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Forekomst af uønskede hændelser, herunder duloxetin-bivirkninger af kvalme, mundtørhed, svimmelhed, somnolens, træthed og søvnløshed (fase II)
Tidsramme: Op til 1 måned efter oxaliplatinbehandling
|
Konstellationen af bivirkninger som scoret ved hjælp af National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) v 5.0 vil blive opsummeret i armene ved at rapportere antallet og procentdelen af patienter.
Andelen af hver af kvalme, mundtørhed, svimmelhed, somnolens, træthed og søvnløshed ved brug af NCI CTCAE v 5.0 vil blive estimeret inden for armene med det nøjagtige 90 % konfidensinterval.
|
Op til 1 måned efter oxaliplatinbehandling
|
|
Seriel målt total sensorisk neuropati score (fase III)
Tidsramme: Op til 1 måned efter oxaliplatinbehandling
|
Sekvensen af de totale sensoriske neuropati-scores for hver patient vil blive målt fra spørgeskemaet om livskvalitet - Kemoterapi-induceret perifer neuropati 20 (QLQ-CIPN20), målt på dag 1 i hver cyklus af oxaliplatin-behandling og 1 måned efter- behandling med oxaliplatin.
Det tilsvarende areal under kurven vil blive beregnet for hver arm baseret på estimerede parametre fra en gentagne målinger (middelværdier) blandet model og sammenlignet.
Analysepopulationen er defineret som alle randomiserede patienter, der modtog mindst 1 dosis oxaliplatin og har en total sensorisk neuropati-score ved mindst 1 lejlighed under oxaliplatinbehandling, inklusive 1 måned post-oxaliplatinbehandling.
|
Op til 1 måned efter oxaliplatinbehandling
|
|
Seriel målt patient rapporteret om de gennemsnitlige smertescores (fase III)
Tidsramme: Op til 1 måned efter oxaliplatinbehandling
|
For hver patient beregnes den samlede sensoriske neuropati score ved at summere de 6 individuelle livskvalitetsspørgeskema - Kemoterapi-induceret perifer neuropati 20 (QLQ-CIPN20) spørgsmål, der kvantificerer følelsesløshed, prikken og smerter i fingre (eller hænder) og tæer (eller fødder) og går fra 1 til 24, hvor højere tal indikerer mere alvorlige symptomer.
Sekvensen af de totale sensoriske neuropati-scores for hver patient vil blive målt på dag 1 i hver cyklus med oxaliplatin-behandling og 1 måned efter oxalipatin-behandling.
Det tilsvarende areal under kurven vil blive beregnet for hver arm baseret på estimerede parametre fra en gentagne målinger (middelværdier) blandet model og sammenlignet.
Analysepopulationen er defineret som alle randomiserede patienter, der modtog mindst 1 dosis oxaliplatin og har en total sensorisk neuropati-score ved mindst 1 lejlighed under oxaliplatinbehandling, inklusive 1 måned post-oxaliplatinbehandling.
|
Op til 1 måned efter oxaliplatinbehandling
|
|
Forekomst af uønskede hændelser, herunder duloxetin-bivirkninger af kvalme, mundtørhed, svimmelhed, somnolens, træthed og søvnløshed (Fase III)
Tidsramme: Op til 1 måned efter oxaliplatinbehandling
|
Konstellationen af bivirkninger som scoret ved hjælp af National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) v 5.0 vil blive opsummeret i armene ved at rapportere antallet og procentdelen af patienter.
Andelen af hver af kvalme, mundtørhed, svimmelhed, somnolens, træthed og søvnløshed ved brug af NCI CTCAE v5.0 vil blive estimeret inden for armene med det nøjagtige 95 % konfidensinterval.
|
Op til 1 måned efter oxaliplatinbehandling
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Samarbejdspartnere
Efterforskere
- Studiestol: Ellen M. Lavoie Smith, PhD, The University of Alabama at Birmingham School of Nursing
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Cho Y, Scott MR, Wilson CM, Daniel M, Odii CO, Wang HL, Carlee J, Kreider J, Smith EML. Nurse Liaison Support to Safeguard the Scientific Rigor of Multisite Clinical Trials: Qualitative Findings From Communications Between Clinical Research Professionals. Cancer Nurs. 2025 Jul 30:10.1097/NCC.0000000000001528. doi: 10.1097/NCC.0000000000001528. Online ahead of print.
- Cho Y, Lavoie Smith EM, Zahrieh D, Chow SL, Williams DA, Saint Arnault D, Jiang Y. Electronic Patient-Reported Outcome Data Collection Systems in Oncology Clinical Trials: A Survey of Clinical Research Professionals (an Alliance Study). JCO Clin Cancer Inform. 2023 Sep;7:e2300007. doi: 10.1200/CCI.23.00007.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
17. juni 2020
Primær færdiggørelse (Anslået)
28. februar 2026
Studieafslutning (Anslået)
31. december 2026
Datoer for studieregistrering
Først indsendt
22. oktober 2019
Først indsendt, der opfyldte QC-kriterier
22. oktober 2019
Først opslået (Faktiske)
23. oktober 2019
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
26. januar 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
23. januar 2026
Sidst verificeret
1. januar 2026
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Neoplasmer efter sted
- Neoplasmer
- Tarmsygdomme
- Gastrointestinale neoplasmer
- Neoplasmer i fordøjelsessystemet
- Sygdomme i fordøjelsessystemet
- Gastrointestinale sygdomme
- Intestinale neoplasmer
- Endetarmssygdomme
- Tyktarmssygdomme
- Kolorektale neoplasmer
- Svovlforbindelser
- Organiske kemikalier
- Heterocykliske forbindelser, 1-ring
- Heterocykliske forbindelser
- Koordinationskomplekser
- Thiophener
- Duloxetinhydrochlorid
- Oxaliplatin
Andre undersøgelses-id-numre
- A221805
- NCI-2019-04727 (Registry Identifier: NCI Clinical Trial Reporting Program)
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Ja
Studerer et amerikansk FDA-reguleret enhedsprodukt
Ingen
produkt fremstillet i og eksporteret fra U.S.A.
Ingen
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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