Test af brugen af målrettet behandling (AMG 510) for KRAS G12C muteret avanceret ikke-pladecellet ikke-småcellet lungekræft (A Lung-MAP Treatment Trial)
4. december 2025 opdateret af: SWOG Cancer Research Network
Et fase II-studie af AMG 510 i deltagere med tidligere behandlet trin IV eller tilbagevendende KRAS G12C-muteret ikke-pladecellet ikke-småcellet lungekræft (ECOG-ACRIN LUNG-MAP SUB-STUDY)
Dette fase II Lung-MAP behandlingsforsøg studerer effekten af AMG 510 til behandling af ikke-pladecellet ikke-småcellet lungekræft, der er stadium IV eller er kommet tilbage (tilbagevendende) og har en specifik mutation i KRAS-genet, kendt som KRAS G12C .
Mutationer i dette gen kan få kræften til at vokse.
AMG 510, en målrettet behandling mod KRAS G12C-mutationen, kan hjælpe med at stoppe væksten af tumorceller.
Studieoversigt
Status
Aktiv, ikke rekrutterende
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
PRIMÆR MÅL:
I. At evaluere responsraten (bekræftet, fuldstændig eller delvis) af AMG 510 hos deltagere med KRAS^G12C-muteret stadium IV eller tilbagevendende ikke-pladecellet ikke-småcellet lungecancer (NSCLC).
SEKUNDÆRE MÅL:
I. At evaluere investigator vurderet progressionsfri overlevelse (IA-PFS) inden for hver kohorte.
II. At evaluere den samlede overlevelse (OS) inden for hver kohorte. III. At evaluere varigheden af respons (DOR) blandt respondere inden for hver kohorte.
IV. At evaluere hyppigheden og sværhedsgraden af toksiciteter inden for hele undersøgelsespopulationen (alle kohorter kombineret).
MÅL FOR TRANSLATIONEL MEDICIN:
I. At evaluere sammenhængen mellem kliniske resultater (respons, IA-PFS, OS) og andre kommutationer (f.eks. CDKN2A/B/C, ATM, PIK3CA) identificeret af Foundation Medicine Inc (FMI) FoundationOne CDx fra LUNGMAP, inden for kohorter og på tværs af hele undersøgelsespopulationen af KRAS^G12C-positive deltagere.
II. At evaluere sammenhængen mellem kliniske resultater (respons, IA-PFS, OS) og PD-L1 total andelsscore bestemt ved screening i LUNGMAP, inden for kohorter og på tværs af hele undersøgelsespopulationen af KRAS^G12C positive deltagere.
III. At evaluere sammenhængen mellem kliniske resultater (respons, IA-PFS, OS) og Tumor Mutational Burden Score bestemt af FMI FoundationOne CDx fra LUNGMAP, inden for kohorter og på tværs af hele undersøgelsespopulationen af KRAS^G12C positive deltagere.
IV. At indsamle, behandle og banke cellefri deoxyribonukleinsyre (cfDNA) ved forbehandling på cyklus 1 dag 1, cyklus 2 dag 1, cyklus 3 dag 1 og ved progression til fremtidig udvikling af et forslag til evaluering af omfattende næste generation sekventering af cirkulerende tumor-DNA (ctDNA) og sammenhæng med kliniske resultater.
Bemærk: Det translationelle lægemiddelforslag til brug af disse prøver vil blive indsendt som en revision til CTEP til godkendelse, før SWOG Statistical and Data Management Center (SDMC) gennemgang af analyseresultater.
OMRIDS:
Patienterne får AMG 510 oralt (PO) én gang dagligt (QD) på dag 1-21. Cykler gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.
Efter afsluttet undersøgelsesbehandling følges patienterne hver 3. måned i 3 år, hvis sygdommen ikke er blevet værre på tidspunktet for afsluttet undersøgelsesbehandling. Hvis sygdommen er blevet værre, følges patienterne hver 6. måned i 2 år, derefter i slutningen af de 3 år fra det tidspunkt, de går på undersøgelse.
Undersøgelsestype
Interventionel
Tilmelding (Anslået)
116
Fase
- Fase 2
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Alabama
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Birmingham, Alabama, Forenede Stater, 35233
- Veterans Administration Medical Center - Birmingham
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Alaska
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Anchorage, Alaska, Forenede Stater, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, Forenede Stater, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, Forenede Stater, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Forenede Stater, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, Forenede Stater, 99504
- Anchorage Radiation Therapy Center
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Fairbanks, Alaska, Forenede Stater, 99701
- Fairbanks Memorial Hospital
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Arizona
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Kingman, Arizona, Forenede Stater, 86401
- Kingman Regional Medical Center
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Phoenix, Arizona, Forenede Stater, 85004
- Cancer Center at Saint Joseph's
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Tucson, Arizona, Forenede Stater, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, Forenede Stater, 85719
- University of Arizona Cancer Center-North Campus
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Arkansas
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Fort Smith, Arkansas, Forenede Stater, 72903
- Mercy Hospital Fort Smith
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Hot Springs, Arkansas, Forenede Stater, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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Jonesboro, Arkansas, Forenede Stater, 72401
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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Little Rock, Arkansas, Forenede Stater, 72205
- University of Arkansas for Medical Sciences
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California
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Anaheim, California, Forenede Stater, 92806
- Kaiser Permanente-Anaheim
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Arroyo Grande, California, Forenede Stater, 93420
- PCR Oncology
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Arroyo Grande, California, Forenede Stater, 93420
- Mission Hope Medical Oncology - Arroyo Grande
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Auburn, California, Forenede Stater, 95602
- Sutter Auburn Faith Hospital
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Auburn, California, Forenede Stater, 95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
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Baldwin Park, California, Forenede Stater, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, Forenede Stater, 90706
- Kaiser Permanente-Bellflower
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Berkeley, California, Forenede Stater, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Beverly Hills, California, Forenede Stater, 90211
- Tower Cancer Research Foundation
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Burbank, California, Forenede Stater, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Cameron Park, California, Forenede Stater, 95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
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Castro Valley, California, Forenede Stater, 94546
- Eden Hospital Medical Center
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Davis, California, Forenede Stater, 95616
- Sutter Davis Hospital
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Duarte, California, Forenede Stater, 91010
- City of Hope Comprehensive Cancer Center
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Fontana, California, Forenede Stater, 92335
- Kaiser Permanente-Fontana
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Fremont, California, Forenede Stater, 94538
- Palo Alto Medical Foundation-Fremont
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Fresno, California, Forenede Stater, 93720
- Kaiser Permanente-Fresno
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Harbor City, California, Forenede Stater, 90710
- Kaiser Permanente South Bay
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Irvine, California, Forenede Stater, 92618
- Kaiser Permanente-Irvine
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La Jolla, California, Forenede Stater, 92093
- UC San Diego Moores Cancer Center
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Long Beach, California, Forenede Stater, 90822
- Tibor Rubin VA Medical Center
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Los Angeles, California, Forenede Stater, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, Forenede Stater, 90048
- Cedars Sinai Medical Center
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Los Angeles, California, Forenede Stater, 90034
- Kaiser Permanente West Los Angeles
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Marysville, California, Forenede Stater, 95901
- Fremont - Rideout Cancer Center
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Modesto, California, Forenede Stater, 95355
- Memorial Medical Center
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Mountain View, California, Forenede Stater, 94040
- Palo Alto Medical Foundation-Camino Division
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Mountain View, California, Forenede Stater, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Oakland, California, Forenede Stater, 94611
- Kaiser Permanente-Oakland
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Ontario, California, Forenede Stater, 91761
- Kaiser Permanente-Ontario
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Palo Alto, California, Forenede Stater, 94304
- Stanford Cancer Institute Palo Alto
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Palo Alto, California, Forenede Stater, 94301
- Palo Alto Medical Foundation Health Care
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Panorama City, California, Forenede Stater, 91402
- Kaiser Permanente - Panorama City
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Rancho Mirage, California, Forenede Stater, 92270
- Eisenhower Medical Center
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Riverside, California, Forenede Stater, 92505
- Kaiser Permanente-Riverside
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Roseville, California, Forenede Stater, 95661
- Kaiser Permanente-Roseville
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Roseville, California, Forenede Stater, 95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
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Roseville, California, Forenede Stater, 95661
- Sutter Roseville Medical Center
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Sacramento, California, Forenede Stater, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, Forenede Stater, 95817
- University of California Davis Comprehensive Cancer Center
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Sacramento, California, Forenede Stater, 95814
- Kaiser Permanente Downtown Commons
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San Diego, California, Forenede Stater, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, Forenede Stater, 92108
- Kaiser Permanente-San Diego Mission
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San Francisco, California, Forenede Stater, 94121
- Veterans Affairs Medical Center - San Francisco
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San Francisco, California, Forenede Stater, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, Forenede Stater, 94115
- California Pacific Medical Center-Pacific Campus
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San Jose, California, Forenede Stater, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, Forenede Stater, 94577
- Kaiser Permanente San Leandro
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San Luis Obispo, California, Forenede Stater, 93401
- Pacific Central Coast Health Center-San Luis Obispo
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San Marcos, California, Forenede Stater, 92078
- Kaiser Permanente-San Marcos
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San Mateo, California, Forenede Stater, 94401
- Mills Health Center
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San Rafael, California, Forenede Stater, 94903
- Kaiser San Rafael-Gallinas
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Santa Clara, California, Forenede Stater, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Cruz, California, Forenede Stater, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Maria, California, Forenede Stater, 93444
- Mission Hope Medical Oncology - Santa Maria
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Santa Rosa, California, Forenede Stater, 95403
- Sutter Pacific Medical Foundation
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South San Francisco, California, Forenede Stater, 94080
- Kaiser Permanente-South San Francisco
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St. Helena, California, Forenede Stater, 94574
- Saint Helena Hospital
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Sunnyvale, California, Forenede Stater, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Tarzana, California, Forenede Stater, 91356
- Cedars-Sinai Cancer - Tarzana
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Torrance, California, Forenede Stater, 90505
- Torrance Memorial Physician Network - Cancer Care
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Truckee, California, Forenede Stater, 96161
- Gene Upshaw Memorial Tahoe Forest Cancer Center
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Upland, California, Forenede Stater, 91786
- City of Hope Upland
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Vallejo, California, Forenede Stater, 94589
- Kaiser Permanente-Vallejo
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Vallejo, California, Forenede Stater, 94589
- Sutter Solano Medical Center/Cancer Center
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Walnut Creek, California, Forenede Stater, 94596
- Kaiser Permanente-Walnut Creek
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Whittier, California, Forenede Stater, 90602
- Presbyterian Intercommunity Hospital
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Woodland Hills, California, Forenede Stater, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, Forenede Stater, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, Forenede Stater, 80012
- The Medical Center of Aurora
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Boulder, Colorado, Forenede Stater, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, Forenede Stater, 80304
- Rocky Mountain Cancer Centers-Boulder
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Centennial, Colorado, Forenede Stater, 80112
- Rocky Mountain Cancer Centers - Centennial
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Colorado Springs, Colorado, Forenede Stater, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Forenede Stater, 80907
- Rocky Mountain Cancer Centers-Penrose
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Denver, Colorado, Forenede Stater, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Forenede Stater, 80220
- Rose Medical Center
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Denver, Colorado, Forenede Stater, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, Forenede Stater, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, Forenede Stater, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, Forenede Stater, 80209
- The Women's Imaging Center
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Denver, Colorado, Forenede Stater, 80220
- Western Surgical Care
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Denver, Colorado, Forenede Stater, 80210
- AdventHealth Porter
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Durango, Colorado, Forenede Stater, 81301
- Mercy Medical Center
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Durango, Colorado, Forenede Stater, 81301
- CommonSpirit Cancer Center Mercy
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Englewood, Colorado, Forenede Stater, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, Forenede Stater, 80113
- Swedish Medical Center
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Englewood, Colorado, Forenede Stater, 80113
- Rocky Mountain Cancer Centers - Swedish
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Englewood, Colorado, Forenede Stater, 80113
- The Melanoma and Skin Cancer Institute
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Greeley, Colorado, Forenede Stater, 80631
- Banner North Colorado Medical Center
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Lakewood, Colorado, Forenede Stater, 80228
- Saint Anthony Hospital
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Lakewood, Colorado, Forenede Stater, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Littleton, Colorado, Forenede Stater, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, Forenede Stater, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, Forenede Stater, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, Forenede Stater, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, Forenede Stater, 80501
- Longmont United Hospital
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Longmont, Colorado, Forenede Stater, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, Forenede Stater, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Parker, Colorado, Forenede Stater, 80138
- AdventHealth Parker
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Pueblo, Colorado, Forenede Stater, 81004
- Saint Mary Corwin Medical Center
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Thornton, Colorado, Forenede Stater, 80260
- Rocky Mountain Cancer Centers-Thornton
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Connecticut
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Derby, Connecticut, Forenede Stater, 06418
- Smilow Cancer Hospital-Derby Care Center
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Fairfield, Connecticut, Forenede Stater, 06824
- Smilow Cancer Hospital Care Center-Fairfield
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Glastonbury, Connecticut, Forenede Stater, 06033
- Smilow Cancer Hospital Care Center at Glastonbury
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Greenwich, Connecticut, Forenede Stater, 06830
- Smilow Cancer Hospital Care Center at Greenwich
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Guilford, Connecticut, Forenede Stater, 06437
- Smilow Cancer Hospital Care Center - Guilford
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Hartford, Connecticut, Forenede Stater, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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Hartford, Connecticut, Forenede Stater, 06102
- Hartford Hospital
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Meriden, Connecticut, Forenede Stater, 06451
- Midstate Medical Center
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New Britain, Connecticut, Forenede Stater, 06050
- The Hospital of Central Connecticut
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New Haven, Connecticut, Forenede Stater, 06520
- Yale University
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North Haven, Connecticut, Forenede Stater, 06473
- Yale-New Haven Hospital North Haven Medical Center
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Orange, Connecticut, Forenede Stater, 06477
- Smilow Cancer Hospital-Orange Care Center
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Stamford, Connecticut, Forenede Stater, 06902
- Smilow Cancer Hospital Care Center at Long Ridge
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Torrington, Connecticut, Forenede Stater, 06790
- Smilow Cancer Hospital-Torrington Care Center
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Trumbull, Connecticut, Forenede Stater, 06611
- Smilow Cancer Hospital Care Center-Trumbull
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Waterbury, Connecticut, Forenede Stater, 06708
- Smilow Cancer Hospital-Waterbury Care Center
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Waterford, Connecticut, Forenede Stater, 06385
- Smilow Cancer Hospital Care Center - Waterford
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West Haven, Connecticut, Forenede Stater, 06516
- Veterans Affairs Connecticut Healthcare System-West Haven Campus
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Delaware
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Dover, Delaware, Forenede Stater, 19901
- Bayhealth Hospital Kent Campus
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Lewes, Delaware, Forenede Stater, 19958
- Beebe Medical Center
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Milford, Delaware, Forenede Stater, 19963
- Bayhealth Hospital Sussex Campus
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Millville, Delaware, Forenede Stater, 19967
- Beebe South Coastal Health Campus
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Newark, Delaware, Forenede Stater, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Forenede Stater, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Forenede Stater, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Forenede Stater, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, Forenede Stater, 19971
- Beebe Health Campus
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Seaford, Delaware, Forenede Stater, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, Forenede Stater, 19801
- Christiana Care Health System-Wilmington Hospital
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District of Columbia
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Washington D.C., District of Columbia, Forenede Stater, 20002
- Kaiser Permanente-Capitol Hill Medical Center
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Florida
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Aventura, Florida, Forenede Stater, 33180
- Mount Sinai Comprehensive Cancer Center at Aventura
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Fort Lauderdale, Florida, Forenede Stater, 33308
- Holy Cross Hospital
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Hollywood, Florida, Forenede Stater, 33021
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital
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Miami Beach, Florida, Forenede Stater, 33140
- Mount Sinai Medical Center
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Tampa, Florida, Forenede Stater, 33612
- Moffitt Cancer Center
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Tampa, Florida, Forenede Stater, 33607
- Moffitt Cancer Center-International Plaza
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Tampa, Florida, Forenede Stater, 33612
- Moffitt Cancer Center - McKinley Campus
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Weston, Florida, Forenede Stater, 33331
- Cleveland Clinic-Weston
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Georgia
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Atlanta, Georgia, Forenede Stater, 30342
- Northside Hospital
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Braselton, Georgia, Forenede Stater, 30517
- Northeast Georgia Medical Center Braselton
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Decatur, Georgia, Forenede Stater, 30033
- Atlanta VA Medical Center
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Duluth, Georgia, Forenede Stater, 30096
- Northside Hospital - Duluth
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Gainesville, Georgia, Forenede Stater, 30501
- Northeast Georgia Medical Center-Gainesville
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Lawrenceville, Georgia, Forenede Stater, 30046
- Northside Hospital - Gwinnett
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Savannah, Georgia, Forenede Stater, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Snellville, Georgia, Forenede Stater, 30078
- Suburban Hematology Oncology Associates - Snellville
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Valdosta, Georgia, Forenede Stater, 31602
- South Georgia Medical Center/Pearlman Cancer Center
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Hawaii
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Honolulu, Hawaii, Forenede Stater, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Forenede Stater, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Forenede Stater, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Forenede Stater, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, Forenede Stater, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Forenede Stater, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Forenede Stater, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, Forenede Stater, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Forenede Stater, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Forenede Stater, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, Forenede Stater, 96817
- Hawaii Diagnostic Radiology Services LLC
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Kahului, Hawaii, Forenede Stater, 96732
- Straub Medical Center - Kahului Clinic
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Kailua, Hawaii, Forenede Stater, 96734
- Castle Medical Center
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Lihue, Hawaii, Forenede Stater, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, Forenede Stater, 96701
- Hawaii Cancer Care - Westridge
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‘Aiea, Hawaii, Forenede Stater, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, Forenede Stater, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, Forenede Stater, 96701
- The Cancer Center of Hawaii-Pali Momi
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‘Ewa Beach, Hawaii, Forenede Stater, 96706
- The Queen's Medical Center - West Oahu
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Idaho
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Boise, Idaho, Forenede Stater, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, Forenede Stater, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, Forenede Stater, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, Forenede Stater, 83814
- Kootenai Health - Coeur d'Alene
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Emmett, Idaho, Forenede Stater, 83617
- Walter Knox Memorial Hospital
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Fruitland, Idaho, Forenede Stater, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, Forenede Stater, 83642
- Idaho Urologic Institute-Meridian
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Meridian, Idaho, Forenede Stater, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, Forenede Stater, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Nampa, Idaho, Forenede Stater, 83687
- Saint Luke's Cancer Institute - Nampa
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Post Falls, Idaho, Forenede Stater, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, Forenede Stater, 83864
- Kootenai Clinic Cancer Services - Sandpoint
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Twin Falls, Idaho, Forenede Stater, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Alton, Illinois, Forenede Stater, 62002
- OSF Saint Anthony's Health Center
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Aurora, Illinois, Forenede Stater, 60504
- Rush-Copley Medical Center
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Barrington, Illinois, Forenede Stater, 60010
- Advocate Good Shepherd Hospital
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Bloomington, Illinois, Forenede Stater, 61704
- Illinois CancerCare-Bloomington
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Canton, Illinois, Forenede Stater, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, Forenede Stater, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, Forenede Stater, 62918
- SIH Cancer Institute
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Carthage, Illinois, Forenede Stater, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Forenede Stater, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, Forenede Stater, 60657
- Advocate Illinois Masonic Medical Center
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Crystal Lake, Illinois, Forenede Stater, 60014
- AMG Crystal Lake - Oncology
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Danville, Illinois, Forenede Stater, 61832
- Carle at The Riverfront
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Decatur, Illinois, Forenede Stater, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Forenede Stater, 62526
- Cancer Care Specialists of Illinois - Decatur
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Dixon, Illinois, Forenede Stater, 61021
- Illinois CancerCare-Dixon
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Downers Grove, Illinois, Forenede Stater, 60515
- Advocate Good Samaritan Hospital
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Effingham, Illinois, Forenede Stater, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, Forenede Stater, 62401
- Carle Physician Group-Effingham
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Elgin, Illinois, Forenede Stater, 60123
- Advocate Sherman Hospital
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Eureka, Illinois, Forenede Stater, 61530
- Illinois CancerCare-Eureka
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Evanston, Illinois, Forenede Stater, 60201
- NorthShore University HealthSystem-Evanston Hospital
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Galesburg, Illinois, Forenede Stater, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, Forenede Stater, 61401
- Illinois CancerCare-Galesburg
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Glenview, Illinois, Forenede Stater, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
-
Harvey, Illinois, Forenede Stater, 60426
- Ingalls Memorial Hospital
-
Hazel Crest, Illinois, Forenede Stater, 60429
- Advocate South Suburban Hospital
-
Highland Park, Illinois, Forenede Stater, 60035
- NorthShore University HealthSystem-Highland Park Hospital
-
Hines, Illinois, Forenede Stater, 60141
- Edward Hines Jr VA Hospital
-
Kewanee, Illinois, Forenede Stater, 61443
- Illinois CancerCare-Kewanee Clinic
-
Libertyville, Illinois, Forenede Stater, 60048
- Condell Memorial Hospital
-
Libertyville, Illinois, Forenede Stater, 60048
- AMG Libertyville - Oncology
-
Macomb, Illinois, Forenede Stater, 61455
- Illinois CancerCare-Macomb
-
Mattoon, Illinois, Forenede Stater, 61938
- Carle Physician Group-Mattoon/Charleston
-
Mount Vernon, Illinois, Forenede Stater, 62864
- SSM Health Good Samaritan
-
O'Fallon, Illinois, Forenede Stater, 62269
- Cancer Care Center of O'Fallon
-
Oak Lawn, Illinois, Forenede Stater, 60453-2699
- Advocate Christ Medical Center
-
Ottawa, Illinois, Forenede Stater, 61350
- Illinois CancerCare-Ottawa Clinic
-
Park Ridge, Illinois, Forenede Stater, 60068
- Advocate Lutheran General Hospital
-
Pekin, Illinois, Forenede Stater, 61554
- Illinois CancerCare-Pekin
-
Peoria, Illinois, Forenede Stater, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Forenede Stater, 61615
- Illinois CancerCare-Peoria
-
Peru, Illinois, Forenede Stater, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Forenede Stater, 61354
- Valley Radiation Oncology
-
Princeton, Illinois, Forenede Stater, 61356
- Illinois CancerCare-Princeton
-
Rockford, Illinois, Forenede Stater, 61108
- OSF Saint Anthony Medical Center
-
Silvis, Illinois, Forenede Stater, 61282
- MercyOne Genesis Silvis Cancer Center
-
Springfield, Illinois, Forenede Stater, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Forenede Stater, 62702
- Springfield Clinic
-
Springfield, Illinois, Forenede Stater, 62781
- Springfield Memorial Hospital
-
Urbana, Illinois, Forenede Stater, 61801
- Carle Cancer Center
-
Urbana, Illinois, Forenede Stater, 61801
- The Carle Foundation Hospital
-
Washington, Illinois, Forenede Stater, 61571
- Illinois CancerCare - Washington
-
Yorkville, Illinois, Forenede Stater, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Fort Wayne, Indiana, Forenede Stater, 46845
- Parkview Regional Medical Center
-
Indianapolis, Indiana, Forenede Stater, 46237
- Franciscan Health Indianapolis
-
Indianapolis, Indiana, Forenede Stater, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
-
Indianapolis, Indiana, Forenede Stater, 46202
- Richard L. Roudebush Veterans Affairs Medical Center
-
Michigan City, Indiana, Forenede Stater, 46360
- Woodland Cancer Care Center
-
Mooresville, Indiana, Forenede Stater, 46158
- Franciscan Health Mooresville
-
Richmond, Indiana, Forenede Stater, 47374
- Reid Health
-
South Bend, Indiana, Forenede Stater, 46601
- Memorial Hospital of South Bend
-
Terre Haute, Indiana, Forenede Stater, 47804
- Union Hospital
-
-
Iowa
-
Ames, Iowa, Forenede Stater, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Forenede Stater, 50010
- McFarland Clinic - Ames
-
Ankeny, Iowa, Forenede Stater, 50023
- UI Health Care Mission Cancer and Blood - Ankeny Clinic
-
Boone, Iowa, Forenede Stater, 50036
- McFarland Clinic - Boone
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Oncology Associates at Mercy Medical Center
-
Clive, Iowa, Forenede Stater, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Forenede Stater, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Council Bluffs, Iowa, Forenede Stater, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, Forenede Stater, 50801
- Greater Regional Medical Center
-
Davenport, Iowa, Forenede Stater, 52807
- Iowa Cancer Specialists
-
Davenport, Iowa, Forenede Stater, 52804
- MercyOne Genesis Davenport Cancer Center
-
Davenport, Iowa, Forenede Stater, 52803
- MercyOne Genesis Davenport Medical Center
-
Des Moines, Iowa, Forenede Stater, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Forenede Stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forenede Stater, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Forenede Stater, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, Forenede Stater, 50501
- McFarland Clinic - Trinity Cancer Center
-
Jefferson, Iowa, Forenede Stater, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Forenede Stater, 50158
- McFarland Clinic - Marshalltown
-
West Des Moines, Iowa, Forenede Stater, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Garden City, Kansas, Forenede Stater, 67846
- Central Care Cancer Center - Garden City
-
Great Bend, Kansas, Forenede Stater, 67530
- Central Care Cancer Center - Great Bend
-
Hays, Kansas, Forenede Stater, 67601
- HaysMed
-
Lawrence, Kansas, Forenede Stater, 66044
- Lawrence Memorial Hospital
-
Olathe, Kansas, Forenede Stater, 66061
- The University of Kansas Cancer Center - Olathe
-
Pittsburg, Kansas, Forenede Stater, 66762
- Freeman Physician Group of Pittsburg
-
Pittsburg, Kansas, Forenede Stater, 66762
- Mercy Hospital Pittsburg
-
Salina, Kansas, Forenede Stater, 67401
- Salina Regional Health Center
-
Topeka, Kansas, Forenede Stater, 66606
- University of Kansas Health System Saint Francis Campus
-
Topeka, Kansas, Forenede Stater, 66606
- Cotton O'Neil Cancer Center / Stormont Vail Health
-
-
Kentucky
-
Bardstown, Kentucky, Forenede Stater, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, Forenede Stater, 40701
- Baptist Health Corbin
-
Corbin, Kentucky, Forenede Stater, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, Forenede Stater, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, Forenede Stater, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Forenede Stater, 40509
- Saint Joseph Hospital East
-
Lexington, Kentucky, Forenede Stater, 40503
- Baptist Health Lexington
-
Lexington, Kentucky, Forenede Stater, 40509
- Baptist Health Hamburg
-
London, Kentucky, Forenede Stater, 40741
- Saint Joseph London
-
Louisville, Kentucky, Forenede Stater, 40202
- Jewish Hospital
-
Louisville, Kentucky, Forenede Stater, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Forenede Stater, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, Forenede Stater, 40215
- Saints Mary and Elizabeth Hospital
-
Shepherdsville, Kentucky, Forenede Stater, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Forenede Stater, 70816
- Medical Center of Baton Rouge
-
Baton Rouge, Louisiana, Forenede Stater, 70836
- Ochsner High Grove
-
Kenner, Louisiana, Forenede Stater, 70065
- Ochsner Medical Center Kenner
-
New Orleans, Louisiana, Forenede Stater, 70121
- Ochsner Medical Center Jefferson
-
-
Maine
-
Bangor, Maine, Forenede Stater, 04401
- Eastern Maine Medical Center
-
Brewer, Maine, Forenede Stater, 04412
- Lafayette Family Cancer Center-EMMC
-
-
Maryland
-
Baltimore, Maryland, Forenede Stater, 21215
- Sinai Hospital of Baltimore
-
Baltimore, Maryland, Forenede Stater, 21229
- Saint Agnes Hospital
-
Baltimore, Maryland, Forenede Stater, 21244
- Kaiser Permanente-Woodlawn Medical Center
-
Cumberland, Maryland, Forenede Stater, 21502
- UPMC Western Maryland
-
Gaithersburg, Maryland, Forenede Stater, 20879
- Kaiser Permanente-Gaithersburg Medical Center
-
Largo, Maryland, Forenede Stater, 20774
- Kaiser Permanente - Largo Medical Center
-
Lutherville, Maryland, Forenede Stater, 21093
- Kaiser Permanente Lutherville - Timonium Medical Center
-
-
Massachusetts
-
Beverly, Massachusetts, Forenede Stater, 01915
- Beverly Hospital
-
Burlington, Massachusetts, Forenede Stater, 01805
- Lahey Hospital and Medical Center
-
Gloucester, Massachusetts, Forenede Stater, 01930
- Addison Gilbert Hospital
-
Jamaica Plain, Massachusetts, Forenede Stater, 02130
- Boston Veteran's Affairs Medical Center
-
Peabody, Massachusetts, Forenede Stater, 01960
- Lahey Medical Center-Peabody
-
Springfield, Massachusetts, Forenede Stater, 01199
- Baystate Medical Center
-
Worcester, Massachusetts, Forenede Stater, 01655
- UMass Memorial Medical Center - University Campus
-
-
Michigan
-
Ann Arbor, Michigan, Forenede Stater, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, Forenede Stater, 49017
- Bronson Battle Creek
-
Brighton, Michigan, Forenede Stater, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, Forenede Stater, 48114
- Trinity Health Medical Center - Brighton
-
Canton, Michigan, Forenede Stater, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, Forenede Stater, 48188
- Trinity Health Medical Center - Canton
-
Caro, Michigan, Forenede Stater, 48723
- Caro Cancer Center
-
Chelsea, Michigan, Forenede Stater, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, Forenede Stater, 48118
- Chelsea Hospital
-
Clarkston, Michigan, Forenede Stater, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, Forenede Stater, 48346
- Newland Medical Associates-Clarkston
-
Detroit, Michigan, Forenede Stater, 48236
- Henry Ford Health Saint John Hospital
-
East China Township, Michigan, Forenede Stater, 48054
- Henry Ford River District Hospital
-
Flint, Michigan, Forenede Stater, 48503
- Hurley Medical Center
-
Flint, Michigan, Forenede Stater, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, Forenede Stater, 48503
- Genesys Hurley Cancer Institute
-
Flint, Michigan, Forenede Stater, 48503
- Cancer Hematology Centers - Flint
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
-
Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Henry Ford Saint John Hospital - Academic
-
Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Henry Ford Saint John Hospital - Breast
-
Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Henry Ford Saint John Hospital - Van Elslander
-
Kalamazoo, Michigan, Forenede Stater, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Forenede Stater, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Forenede Stater, 49009
- Beacon Kalamazoo Cancer Center
-
Kalamazoo, Michigan, Forenede Stater, 49048
- Beacon Kalamazoo
-
Lansing, Michigan, Forenede Stater, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Forenede Stater, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, Forenede Stater, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, Forenede Stater, 48044
- Henry Ford Warren Hospital - Breast Macomb
-
Macomb, Michigan, Forenede Stater, 48044
- Henry Ford Saint John Hospital - Macomb Medical
-
Marlette, Michigan, Forenede Stater, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Muskegon, Michigan, Forenede Stater, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, Forenede Stater, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Norton Shores, Michigan, Forenede Stater, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Pontiac, Michigan, Forenede Stater, 48341
- Hope Cancer Center
-
Pontiac, Michigan, Forenede Stater, 48341
- Newland Medical Associates-Pontiac
-
Pontiac, Michigan, Forenede Stater, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Pontiac, Michigan, Forenede Stater, 48341
- Michigan Healthcare Professionals Pontiac
-
Reed City, Michigan, Forenede Stater, 49677
- Corewell Health Reed City Hospital
-
Saginaw, Michigan, Forenede Stater, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saginaw, Michigan, Forenede Stater, 48601
- MyMichigan Medical Center Saginaw
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Sterling Heights, Michigan, Forenede Stater, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Tawas City, Michigan, Forenede Stater, 48764
- MyMichigan Medical Center Tawas
-
Traverse City, Michigan, Forenede Stater, 49684
- Munson Medical Center
-
Warren, Michigan, Forenede Stater, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, Forenede Stater, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, Forenede Stater, 48093
- Henry Ford Madison Heights Hospital - Breast
-
Warren, Michigan, Forenede Stater, 48093
- Henry Ford Health Warren Hospital
-
Warren, Michigan, Forenede Stater, 48093
- Henry Ford Warren Hospital - GLCMS
-
West Branch, Michigan, Forenede Stater, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyoming, Michigan, Forenede Stater, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, Forenede Stater, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, Forenede Stater, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Aitkin, Minnesota, Forenede Stater, 56431
- Riverwood Healthcare Center
-
Bemidji, Minnesota, Forenede Stater, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Forenede Stater, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Forenede Stater, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, Forenede Stater, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, Forenede Stater, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, Forenede Stater, 55433
- Mercy Hospital
-
Deer River, Minnesota, Forenede Stater, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, Forenede Stater, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Forenede Stater, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Forenede Stater, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Forenede Stater, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston, Minnesota, Forenede Stater, 56542
- Essentia Health - Fosston
-
Fridley, Minnesota, Forenede Stater, 55432
- Unity Hospital
-
Hibbing, Minnesota, Forenede Stater, 55746
- Essentia Health Hibbing Clinic
-
Maple Grove, Minnesota, Forenede Stater, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Forenede Stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forenede Stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forenede Stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Forenede Stater, 55454
- Health Partners Inc
-
Minneapolis, Minnesota, Forenede Stater, 55417
- Minneapolis VA Medical Center
-
Monticello, Minnesota, Forenede Stater, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, Forenede Stater, 56073
- New Ulm Medical Center
-
Park Rapids, Minnesota, Forenede Stater, 56470
- Essentia Health - Park Rapids
-
Princeton, Minnesota, Forenede Stater, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, Forenede Stater, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Forenede Stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forenede Stater, 55102
- United Hospital
-
Sandstone, Minnesota, Forenede Stater, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, Forenede Stater, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Forenede Stater, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, Forenede Stater, 56701
- Sanford Thief River Falls Medical Center
-
Virginia, Minnesota, Forenede Stater, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, Forenede Stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forenede Stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forenede Stater, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, Forenede Stater, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, Forenede Stater, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Columbus, Mississippi, Forenede Stater, 39705
- Baptist Memorial Hospital and Cancer Center-Golden Triangle
-
Grenada, Mississippi, Forenede Stater, 38901
- Baptist Cancer Center-Grenada
-
Jackson, Mississippi, Forenede Stater, 39216
- University of Mississippi Medical Center
-
New Albany, Mississippi, Forenede Stater, 38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford, Mississippi, Forenede Stater, 38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Southhaven, Mississippi, Forenede Stater, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Ballwin, Missouri, Forenede Stater, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar, Missouri, Forenede Stater, 65613
- Central Care Cancer Center - Bolivar
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Mercy Cancer Center - Cape Girardeau
-
Farmington, Missouri, Forenede Stater, 63640
- Parkland Health Center - Farmington
-
Jefferson City, Missouri, Forenede Stater, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Forenede Stater, 64804
- Freeman Health System
-
Joplin, Missouri, Forenede Stater, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, Forenede Stater, 64111
- Saint Luke's Hospital of Kansas City
-
Kansas City, Missouri, Forenede Stater, 64108
- University Health Truman Medical Center
-
Lee's Summit, Missouri, Forenede Stater, 64086
- Saint Luke's East - Lee's Summit
-
Rolla, Missouri, Forenede Stater, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Forenede Stater, 65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph, Missouri, Forenede Stater, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, Forenede Stater, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Forenede Stater, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Forenede Stater, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Forenede Stater, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Forenede Stater, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Forenede Stater, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, Forenede Stater, 63128
- Mercy Hospital South
-
St Louis, Missouri, Forenede Stater, 63125
- Veteran's Affairs Medical Center - Saint Louis
-
Sullivan, Missouri, Forenede Stater, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, Forenede Stater, 63127
- BJC Outpatient Center at Sunset Hills
-
Washington, Missouri, Forenede Stater, 63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda, Montana, Forenede Stater, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Forenede Stater, 59101
- Billings Clinic Cancer Center
-
Bozeman, Montana, Forenede Stater, 59715
- Bozeman Health Deaconess Hospital
-
Great Falls, Montana, Forenede Stater, 59405
- Great Falls Clinic
-
Great Falls, Montana, Forenede Stater, 59405
- Benefis Sletten Cancer Institute
-
Kalispell, Montana, Forenede Stater, 59901
- Logan Health Medical Center
-
Missoula, Montana, Forenede Stater, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Forenede Stater, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, Forenede Stater, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Forenede Stater, 68847
- CHI Health Good Samaritan
-
Lincoln, Nebraska, Forenede Stater, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, Forenede Stater, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Forenede Stater, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Forenede Stater, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Forenede Stater, 68131
- Creighton University Medical Center
-
Papillion, Nebraska, Forenede Stater, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, Forenede Stater, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, Forenede Stater, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- OptumCare Cancer Care at Seven Hills
-
Henderson, Nevada, Forenede Stater, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Forenede Stater, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, Forenede Stater, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, Forenede Stater, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, Forenede Stater, 89074
- Urology Specialists of Nevada - Green Valley
-
Henderson, Nevada, Forenede Stater, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, Forenede Stater, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Forenede Stater, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Forenede Stater, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Forenede Stater, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Forenede Stater, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Forenede Stater, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Forenede Stater, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Forenede Stater, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Forenede Stater, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Forenede Stater, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, Forenede Stater, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Forenede Stater, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Forenede Stater, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, Forenede Stater, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, Forenede Stater, 89102
- Desert West Surgery
-
Las Vegas, Nevada, Forenede Stater, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, Forenede Stater, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, Forenede Stater, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, Forenede Stater, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, Forenede Stater, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, Forenede Stater, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, Forenede Stater, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, Forenede Stater, 89169
- University Cancer Center
-
Las Vegas, Nevada, Forenede Stater, 89113
- Urology Specialists of Nevada - Southwest
-
Las Vegas, Nevada, Forenede Stater, 89128
- Oncology Las Vegas - Tenaya
-
Pahrump, Nevada, Forenede Stater, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, Forenede Stater, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Forenede Stater, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Forenede Stater, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Concord, New Hampshire, Forenede Stater, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Lebanon, New Hampshire, Forenede Stater, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
Manchester, New Hampshire, Forenede Stater, 03103
- Solinsky Center for Cancer Care
-
-
New Jersey
-
Brick, New Jersey, Forenede Stater, 08724
- Ocean University Medical Center
-
Manahawkin, New Jersey, Forenede Stater, 08050
- Southern Ocean County Medical Center
-
Moorestown, New Jersey, Forenede Stater, 08057
- Virtua Samson Cancer Center
-
Mount Holly, New Jersey, Forenede Stater, 08060
- Virtua Memorial
-
Neptune City, New Jersey, Forenede Stater, 07753
- Jersey Shore Medical Center
-
Red Bank, New Jersey, Forenede Stater, 07701
- Riverview Medical Center/Booker Cancer Center
-
Voorhees Township, New Jersey, Forenede Stater, 08043
- Virtua Voorhees
-
-
New Mexico
-
Albuquerque, New Mexico, Forenede Stater, 87106
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, Forenede Stater, 87110
- Presbyterian Kaseman Hospital
-
Rio Rancho, New Mexico, Forenede Stater, 87124
- Presbyterian Rust Medical Center/Jorgensen Cancer Center
-
-
New York
-
Buffalo, New York, Forenede Stater, 14263
- Roswell Park Cancer Institute
-
Cooperstown, New York, Forenede Stater, 13326
- Mary Imogene Bassett Hospital
-
East Hills, New York, Forenede Stater, 11548
- The Cancer Institute at Saint Francis Hospital
-
Elmira, New York, Forenede Stater, 14905
- Arnot Ogden Medical Center/Falck Cancer Center
-
Glens Falls, New York, Forenede Stater, 12801
- Glens Falls Hospital
-
Rochester, New York, Forenede Stater, 14642
- University of Rochester
-
The Bronx, New York, Forenede Stater, 10468
- James J Peters VA Medical Center
-
West Islip, New York, Forenede Stater, 11795
- Good Samaritan University Hospital
-
-
North Carolina
-
Asheboro, North Carolina, Forenede Stater, 27203
- Randolph Hospital
-
Asheboro, North Carolina, Forenede Stater, 27203
- Cone Health Cancer Center at Asheboro
-
Asheboro, North Carolina, Forenede Stater, 27205
- Cone Health MedCenter Asheboro
-
Asheville, North Carolina, Forenede Stater, 28803
- AdventHealth Infusion Center Asheville
-
Burlington, North Carolina, Forenede Stater, 27215
- Cone Health Cancer Center at Alamance Regional
-
Clyde, North Carolina, Forenede Stater, 28721
- AdventHealth Infusion Center Haywood
-
Durham, North Carolina, Forenede Stater, 27705
- Durham VA Medical Center
-
Greensboro, North Carolina, Forenede Stater, 27403
- Cone Health Cancer Center
-
Greensboro, North Carolina, Forenede Stater, 27410
- Cone Health Cancer Center at Drawbridge Parkway
-
Hendersonville, North Carolina, Forenede Stater, 28792
- AdventHealth Hendersonville
-
Mebane, North Carolina, Forenede Stater, 27302
- Cone Heath Cancer Center at Mebane
-
Reidsville, North Carolina, Forenede Stater, 27320
- Annie Penn Memorial Hospital
-
Weaverville, North Carolina, Forenede Stater, 28787
- AdventHealth Infusion Center Weaverville
-
-
North Dakota
-
Bismarck, North Dakota, Forenede Stater, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Forenede Stater, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, Forenede Stater, 58103
- Sanford South University Medical Center
-
Fargo, North Dakota, Forenede Stater, 58103
- Southpointe-Sanford Medical Center Fargo
-
Fargo, North Dakota, Forenede Stater, 58104
- Sanford Medical Center Fargo
-
Jamestown, North Dakota, Forenede Stater, 58401
- Essentia Health - Jamestown Clinic
-
-
Ohio
-
Alliance, Ohio, Forenede Stater, 44601
- Aultman Alliance Community Hospital
-
Beavercreek, Ohio, Forenede Stater, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, Forenede Stater, 45714
- Strecker Cancer Center-Belpre
-
Boardman, Ohio, Forenede Stater, 44512
- Saint Elizabeth Boardman Hospital
-
Canton, Ohio, Forenede Stater, 44708
- Cleveland Clinic Mercy Hospital
-
Canton, Ohio, Forenede Stater, 44710
- Aultman Health Foundation
-
Centerville, Ohio, Forenede Stater, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Forenede Stater, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, Forenede Stater, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Forenede Stater, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Forenede Stater, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Forenede Stater, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, Forenede Stater, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Forenede Stater, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Forenede Stater, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, Forenede Stater, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Cleveland, Ohio, Forenede Stater, 44106
- Louis Stokes Cleveland VA Medical Center
-
Columbus, Ohio, Forenede Stater, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Forenede Stater, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Forenede Stater, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Forenede Stater, 43228
- Doctors Hospital
-
Columbus, Ohio, Forenede Stater, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, Forenede Stater, 43215
- Grant Medical Center
-
Columbus, Ohio, Forenede Stater, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, Forenede Stater, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Forenede Stater, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Forenede Stater, 45415
- Dayton Physician LLC - Englewood
-
Dayton, Ohio, Forenede Stater, 45409
- Premier Blood and Cancer Center
-
Delaware, Ohio, Forenede Stater, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Forenede Stater, 43015
- Grady Memorial Hospital
-
Dublin, Ohio, Forenede Stater, 43016
- Dublin Methodist Hospital
-
Findlay, Ohio, Forenede Stater, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Forenede Stater, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Forenede Stater, 45840
- Orion Cancer Care
-
Franklin, Ohio, Forenede Stater, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Forenede Stater, 45005
- Dayton Physicians LLC-Atrium
-
Gahanna, Ohio, Forenede Stater, 43230
- Central Ohio Breast and Endocrine Surgery
-
Greenville, Ohio, Forenede Stater, 45331
- Wayne Hospital
-
Greenville, Ohio, Forenede Stater, 45331
- Dayton Physicians LLC-Wayne
-
Greenville, Ohio, Forenede Stater, 45331
- Miami Valley Cancer Care and Infusion
-
Grove City, Ohio, Forenede Stater, 43123
- Mount Carmel Grove City Hospital
-
Kettering, Ohio, Forenede Stater, 45429
- Kettering Medical Center
-
Kettering, Ohio, Forenede Stater, 45409
- Greater Dayton Cancer Center
-
Lancaster, Ohio, Forenede Stater, 43130
- Fairfield Medical Center
-
Lima, Ohio, Forenede Stater, 45801
- Saint Rita's Medical Center
-
Mansfield, Ohio, Forenede Stater, 44906
- Cleveland Clinic Cancer Center Mansfield
-
Mansfield, Ohio, Forenede Stater, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, Forenede Stater, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, Forenede Stater, 43302
- OhioHealth Marion General Hospital
-
Marysville, Ohio, Forenede Stater, 43040
- Memorial Hospital
-
Mayfield Heights, Ohio, Forenede Stater, 44124
- Hillcrest Hospital Cancer Center
-
Mount Vernon, Ohio, Forenede Stater, 43050
- Knox Community Hospital
-
Newark, Ohio, Forenede Stater, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Forenede Stater, 43055
- Newark Radiation Oncology
-
Perrysburg, Ohio, Forenede Stater, 43551
- Mercy Health - Perrysburg Hospital
-
Portsmouth, Ohio, Forenede Stater, 45662
- Southern Ohio Medical Center
-
Sandusky, Ohio, Forenede Stater, 44870
- North Coast Cancer Care
-
Springfield, Ohio, Forenede Stater, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Forenede Stater, 45504
- Springfield Regional Medical Center
-
Steubenville, Ohio, Forenede Stater, 43952
- Trinity's Tony Teramana Cancer Center
-
Strongsville, Ohio, Forenede Stater, 44136
- Cleveland Clinic Cancer Center Strongsville
-
Sylvania, Ohio, Forenede Stater, 43560
- ProMedica Flower Hospital
-
Toledo, Ohio, Forenede Stater, 43606
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
-
Toledo, Ohio, Forenede Stater, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, Forenede Stater, 43608
- Mercy Health - Saint Vincent Hospital
-
Troy, Ohio, Forenede Stater, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Forenede Stater, 45373
- Dayton Physicians LLC - Troy
-
Warren, Ohio, Forenede Stater, 44484
- Saint Joseph Warren Hospital
-
Warrensville Heights, Ohio, Forenede Stater, 44122
- South Pointe Hospital
-
Westerville, Ohio, Forenede Stater, 43081
- Saint Ann's Hospital
-
Wooster, Ohio, Forenede Stater, 44691
- Cleveland Clinic Wooster Family Health and Surgery Center
-
Youngstown, Ohio, Forenede Stater, 44501
- Saint Elizabeth Youngstown Hospital
-
Zanesville, Ohio, Forenede Stater, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Forenede Stater, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Forenede Stater, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Forenede Stater, 73120
- Mercy Hospital Oklahoma City
-
-
Oregon
-
Baker City, Oregon, Forenede Stater, 97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Bend, Oregon, Forenede Stater, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Forenede Stater, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Forenede Stater, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Forenede Stater, 97420
- Bay Area Hospital
-
Newberg, Oregon, Forenede Stater, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Forenede Stater, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Oregon City, Oregon, Forenede Stater, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, Forenede Stater, 97239
- Oregon Health and Science University
-
Portland, Oregon, Forenede Stater, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Forenede Stater, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Forenede Stater, 97227
- Kaiser Permanente Northwest
-
Redmond, Oregon, Forenede Stater, 97756
- Saint Charles Health System-Redmond
-
Salem, Oregon, Forenede Stater, 97301
- Salem Hospital
-
-
Pennsylvania
-
Allentown, Pennsylvania, Forenede Stater, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Altoona, Pennsylvania, Forenede Stater, 16601
- UPMC Altoona
-
Beaver, Pennsylvania, Forenede Stater, 15009
- UPMC-Heritage Valley Health System Beaver
-
Bethlehem, Pennsylvania, Forenede Stater, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Butler, Pennsylvania, Forenede Stater, 16001
- UPMC Hillman Cancer Center at Butler Health System
-
Camp Hill, Pennsylvania, Forenede Stater, 17011
- UPMC Camp Hill
-
Carlisle, Pennsylvania, Forenede Stater, 17015
- Carlisle Regional Cancer Center
-
Chadds Ford, Pennsylvania, Forenede Stater, 19317
- Christiana Care Health System-Concord Health Center
-
Chambersburg, Pennsylvania, Forenede Stater, 17201
- Chambersburg Hospital
-
Chambersburg, Pennsylvania, Forenede Stater, 17201
- WellSpan Medical Oncology and Hematology
-
East Norriton, Pennsylvania, Forenede Stater, 19401
- Fox Chase Cancer Center - East Norriton Hospital Outpatient Center
-
East Stroudsburg, Pennsylvania, Forenede Stater, 18301
- Pocono Medical Center
-
Ephrata, Pennsylvania, Forenede Stater, 17522
- Ephrata Cancer Center
-
Ephrata, Pennsylvania, Forenede Stater, 17522
- Ephrata Community Hospital
-
Erie, Pennsylvania, Forenede Stater, 16505
- UPMC Hillman Cancer Center Erie
-
Farrell, Pennsylvania, Forenede Stater, 16121
- UPMC Cancer Center at UPMC Horizon
-
Gettysburg, Pennsylvania, Forenede Stater, 17325
- Adams Cancer Center
-
Greensburg, Pennsylvania, Forenede Stater, 15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Greenville, Pennsylvania, Forenede Stater, 16125
- UPMC Hillman Cancer Center in Greenville/UPMC Horizon
-
Hanover, Pennsylvania, Forenede Stater, 17331
- WellSpan Medical Oncology and Hematology
-
Harrisburg, Pennsylvania, Forenede Stater, 17109
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Hazleton, Pennsylvania, Forenede Stater, 18201
- Lehigh Valley Hospital-Hazleton
-
Indiana, Pennsylvania, Forenede Stater, 15701
- IRMC Cancer Center
-
Johnstown, Pennsylvania, Forenede Stater, 15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lebanon, Pennsylvania, Forenede Stater, 17042
- Sechler Family Cancer Center
-
McKeesport, Pennsylvania, Forenede Stater, 15132
- UPMC Cancer Center at UPMC McKeesport
-
Mechanicsburg, Pennsylvania, Forenede Stater, 17050
- UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
-
Monroeville, Pennsylvania, Forenede Stater, 15146
- UPMC Hillman Cancer Center - Monroeville
-
Moon Township, Pennsylvania, Forenede Stater, 15108
- UPMC Hillman Cancer Center in Coraopolis
-
Mount Pleasant, Pennsylvania, Forenede Stater, 15666
- UPMC Hillman Cancer Center - Part of Frick Hospital
-
N. Huntingdon, Pennsylvania, Forenede Stater, 15642
- Arnold Palmer Cancer Center Medical Oncology Norwin
-
Natrona Heights, Pennsylvania, Forenede Stater, 15065
- UPMC Cancer Center-Natrona Heights
-
New Castle, Pennsylvania, Forenede Stater, 16105
- UPMC Hillman Cancer Center - New Castle
-
Philadelphia, Pennsylvania, Forenede Stater, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, Forenede Stater, 19140
- Temple University Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15232
- University of Pittsburgh Cancer Institute (UPCI)
-
Pittsburgh, Pennsylvania, Forenede Stater, 15215
- UPMC-Saint Margaret
-
Pittsburgh, Pennsylvania, Forenede Stater, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottstown, Pennsylvania, Forenede Stater, 19464
- Pottstown Hospital
-
Seneca, Pennsylvania, Forenede Stater, 16346
- UPMC Cancer Center at UPMC Northwest
-
Uniontown, Pennsylvania, Forenede Stater, 15401
- UPMC Cancer Center-Uniontown
-
Washington, Pennsylvania, Forenede Stater, 15301
- UPMC Cancer Center-Washington
-
West Mifflin, Pennsylvania, Forenede Stater, 15122
- UPMC West Mifflin-Cancer Center Jefferson
-
Williamsport, Pennsylvania, Forenede Stater, 17701
- UPMC Susquehanna
-
Williamsport, Pennsylvania, Forenede Stater, 17754
- Divine Providence Hospital
-
York, Pennsylvania, Forenede Stater, 17403
- WellSpan Health-York Cancer Center
-
York, Pennsylvania, Forenede Stater, 17403
- WellSpan Health-York Hospital
-
York, Pennsylvania, Forenede Stater, 17403
- Cancer Care Associates of York
-
York, Pennsylvania, Forenede Stater, 17408
- UPMC Memorial
-
-
Rhode Island
-
Providence, Rhode Island, Forenede Stater, 02908
- Providence Veterans Administration Hospital
-
Westerly, Rhode Island, Forenede Stater, 02891
- Smilow Cancer Hospital Care Center - Westerly
-
-
South Carolina
-
Anderson, South Carolina, Forenede Stater, 29621
- AnMed Health Cancer Center
-
Bluffton, South Carolina, Forenede Stater, 29910
- Saint Joseph's/Candler - Bluffton Campus
-
Boiling Springs, South Carolina, Forenede Stater, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, Forenede Stater, 29425
- Medical University of South Carolina
-
Charleston, South Carolina, Forenede Stater, 29401
- Ralph H Johnson VA Medical Center
-
Easley, South Carolina, Forenede Stater, 29640
- Prisma Health Cancer Institute - Easley
-
Greenville, South Carolina, Forenede Stater, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Forenede Stater, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Forenede Stater, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Forenede Stater, 29605
- Prisma Health Greenville Memorial Hospital
-
Greer, South Carolina, Forenede Stater, 29650
- Prisma Health Cancer Institute - Greer
-
Seneca, South Carolina, Forenede Stater, 29672
- Prisma Health Cancer Institute - Seneca
-
-
South Dakota
-
Rapid City, South Dakota, Forenede Stater, 57701
- Rapid City Regional Hospital
-
Sioux Falls, South Dakota, Forenede Stater, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Forenede Stater, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Collierville, Tennessee, Forenede Stater, 38017
- Baptist Memorial Hospital and Cancer Center-Collierville
-
Memphis, Tennessee, Forenede Stater, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
-
Texas
-
Amarillo, Texas, Forenede Stater, 79106
- The Don and Sybil Harrington Cancer Center
-
Bryan, Texas, Forenede Stater, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, Forenede Stater, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, Forenede Stater, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Fort Worth, Texas, Forenede Stater, 76104
- UT Southwestern/Simmons Cancer Center-Fort Worth
-
Richardson, Texas, Forenede Stater, 75080
- UT Southwestern Clinical Center at Richardson/Plano
-
-
Vermont
-
Berlin Corners, Vermont, Forenede Stater, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Forenede Stater, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Forenede Stater, 05405
- University of Vermont and State Agricultural College
-
White River Junction, Vermont, Forenede Stater, 05009
- White River Junction Veteran Administration Medical Center
-
-
Virginia
-
Burke, Virginia, Forenede Stater, 22015
- Kaiser Permanente-Burke Medical Center
-
Lynchburg, Virginia, Forenede Stater, 24501
- Centra Alan B Pearson Regional Cancer Center
-
McLean, Virginia, Forenede Stater, 22102
- Kaiser Permanente Tysons Corner Medical Center
-
Mechanicsville, Virginia, Forenede Stater, 23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian, Virginia, Forenede Stater, 23114
- Bon Secours Saint Francis Medical Center
-
Midlothian, Virginia, Forenede Stater, 23113
- Bon Secours Westchester Emergency Center
-
Norfolk, Virginia, Forenede Stater, 23505
- Bon Secours DePaul Medical Center
-
Portsmouth, Virginia, Forenede Stater, 23707
- Bon Secours Maryview Medical Center
-
Richmond, Virginia, Forenede Stater, 23235
- VCU Massey Cancer Center at Stony Point
-
Richmond, Virginia, Forenede Stater, 23229
- Virginia Cancer Institute
-
Richmond, Virginia, Forenede Stater, 23226
- Bon Secours Saint Mary's Hospital
-
Richmond, Virginia, Forenede Stater, 23230
- Bon Secours Cancer Institute at Reynolds Crossing
-
Richmond, Virginia, Forenede Stater, 23249
- Hunter Holmes McGuire Veterans Administration Medical Center
-
Richmond, Virginia, Forenede Stater, 23298
- VCU Massey Comprehensive Cancer Center
-
South Hill, Virginia, Forenede Stater, 23970
- VCU Community Memorial Health Center
-
Suffolk, Virginia, Forenede Stater, 23435
- Bon Secours Health Center at Harbour View
-
Woodbridge, Virginia, Forenede Stater, 22192
- Kaiser Permanente-Caton Hill Medical Center
-
-
Washington
-
Aberdeen, Washington, Forenede Stater, 98520
- Providence Regional Cancer System-Aberdeen
-
Bellevue, Washington, Forenede Stater, 98004
- Overlake Medical Center
-
Bellingham, Washington, Forenede Stater, 98225
- PeaceHealth Saint Joseph Medical Center
-
Burien, Washington, Forenede Stater, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, Forenede Stater, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Forenede Stater, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, Forenede Stater, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Forenede Stater, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Forenede Stater, 98003
- Saint Francis Hospital
-
Issaquah, Washington, Forenede Stater, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Forenede Stater, 99336
- Kadlec Clinic Hematology and Oncology
-
Lacey, Washington, Forenede Stater, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Forenede Stater, 98499
- Saint Clare Hospital
-
Longview, Washington, Forenede Stater, 98632
- PeaceHealth Saint John Medical Center
-
Port Townsend, Washington, Forenede Stater, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, Forenede Stater, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Renton, Washington, Forenede Stater, 98055
- Valley Medical Center
-
Seattle, Washington, Forenede Stater, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Forenede Stater, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Forenede Stater, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, Forenede Stater, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Sedro-Woolley, Washington, Forenede Stater, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, Forenede Stater, 98584
- Providence Regional Cancer System-Shelton
-
Silverdale, Washington, Forenede Stater, 98383
- Saint Michael Cancer Center
-
Tacoma, Washington, Forenede Stater, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, Forenede Stater, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Forenede Stater, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Forenede Stater, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, Forenede Stater, 98597
- Providence Regional Cancer System-Yelm
-
-
West Virginia
-
Huntington, West Virginia, Forenede Stater, 25701
- Edwards Comprehensive Cancer Center
-
Huntington, West Virginia, Forenede Stater, 25702
- Saint Mary's Medical Center
-
Morgantown, West Virginia, Forenede Stater, 26506
- West Virginia University Healthcare
-
-
Wisconsin
-
Antigo, Wisconsin, Forenede Stater, 54409
- Langlade Hospital and Cancer Center
-
Appleton, Wisconsin, Forenede Stater, 54915
- Ascension Saint Elizabeth Hospital
-
Ashland, Wisconsin, Forenede Stater, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, Forenede Stater, 54806
- Northwest Wisconsin Cancer Center
-
Brookfield, Wisconsin, Forenede Stater, 53045
- Ascension Southeast Wisconsin Hospital - Elmbrook Campus
-
Burlington, Wisconsin, Forenede Stater, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chilton, Wisconsin, Forenede Stater, 53014
- Ascension Calumet Hospital
-
Cudahy, Wisconsin, Forenede Stater, 53110
- Aurora Saint Luke's South Shore
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- Marshfield Medical Center-EC Cancer Center
-
Franklin, Wisconsin, Forenede Stater, 53132
- Ascension Saint Francis - Reiman Cancer Center
-
Franklin, Wisconsin, Forenede Stater, 53132
- Ascension Southeast Wisconsin Hospital - Franklin
-
Germantown, Wisconsin, Forenede Stater, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Forenede Stater, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Forenede Stater, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Forenede Stater, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Forenede Stater, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Kenosha, Wisconsin, Forenede Stater, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Forenede Stater, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, Forenede Stater, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Marinette, Wisconsin, Forenede Stater, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Medical Center-Marshfield
-
Medford, Wisconsin, Forenede Stater, 54451
- Aspirus Medford Hospital
-
Mequon, Wisconsin, Forenede Stater, 53097
- Ascension Columbia Saint Mary's Hospital Ozaukee
-
Milwaukee, Wisconsin, Forenede Stater, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Forenede Stater, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Forenede Stater, 53233
- Aurora Sinai Medical Center
-
Milwaukee, Wisconsin, Forenede Stater, 53210
- Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
-
Milwaukee, Wisconsin, Forenede Stater, 53211
- Ascension Columbia Saint Mary's Hospital - Milwaukee
-
Milwaukee, Wisconsin, Forenede Stater, 53215
- Ascension Saint Francis Hospital
-
Minocqua, Wisconsin, Forenede Stater, 54548
- Marshfield Medical Center - Minocqua
-
New Richmond, Wisconsin, Forenede Stater, 54017
- Cancer Center of Western Wisconsin
-
Oconto Falls, Wisconsin, Forenede Stater, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, Forenede Stater, 54904
- Ascension Mercy Hospital
-
Oshkosh, Wisconsin, Forenede Stater, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Forenede Stater, 53406
- Aurora Cancer Care-Racine
-
Racine, Wisconsin, Forenede Stater, 53405
- Ascension All Saints Hospital
-
Rhinelander, Wisconsin, Forenede Stater, 54501
- Aspirus Cancer Care - James Beck Cancer Center
-
Rice Lake, Wisconsin, Forenede Stater, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, Forenede Stater, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Stevens Point, Wisconsin, Forenede Stater, 54481
- Aspirus Cancer Care - Stevens Point
-
Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit, Wisconsin, Forenede Stater, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Forenede Stater, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Wausau, Wisconsin, Forenede Stater, 54401
- Aspirus Regional Cancer Center
-
Wauwatosa, Wisconsin, Forenede Stater, 53226
- Aurora Cancer Care-Milwaukee West
-
Wauwatosa, Wisconsin, Forenede Stater, 53226
- Ascension Medical Group Southeast Wisconsin - Mayfair Road
-
West Allis, Wisconsin, Forenede Stater, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Forenede Stater, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
-
Wyoming
-
Cheyenne, Wyoming, Forenede Stater, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, Forenede Stater, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Forenede Stater, 82801
- Welch Cancer Center
-
-
-
-
-
Tamuning, Guam, 96913
- FHP Health Center-Guam
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
14 år og ældre (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Beskrivelse
Inklusionskriterier:
- Deltagere skal tildeles S1900E. Tildeling til S1900E bestemmes af LUNGMAP-protokollens genomiske profilering ved hjælp af FoundationOne-analysen. Biomarkør berettigelse til S1900E er baseret på identifikation af en KRAS^G12C mutation
- Deltagerne skal have bekræftet stadie IV eller tilbagevendende ikke-pladeeplade ikke-småcellet lungekræft (NSCLC). Blandet histologisk NSCLC med mindre end 50 % pladebeholder er tilladt
- Deltagerne skal have målbar sygdom dokumenteret ved computertomografi (CT) eller magnetisk resonansbilleddannelse (MRI). CT'en fra en kombineret positronemissionstomografi (PET)/CT kan kun bruges til at dokumentere ikke-målbar sygdom, medmindre den er af diagnostisk kvalitet. Målbar sygdom skal vurderes inden for 28 dage før delstudieregistrering. Pleural effusion, ascites og laboratorieparametre er ikke acceptable som det eneste tegn på sygdom. Ikke-målbar sygdom skal vurderes inden for 42 dage før delstudieregistrering. Deltagere, hvis eneste målbare sygdom er inden for en tidligere stråleterapiport, skal demonstrere klart fremadskridende sygdom (efter den behandlende investigators mening) før registrering
- Deltagerne skal have en CT- eller MR-scanning af hjernen for at evaluere for sygdom i centralnervesystemet (CNS) inden for 42 dage før registrering af delstudiet
- Deltagere med kendt human immundefektvirus (HIV)-infektion skal modtage antiretroviral behandling og have en upåviselig virusbelastning ved deres seneste virusbelastningstest inden for 6 måneder før registrering af delstudiet
- Deltagere med EGFR-sensibiliserende mutationer, EGFR T790M-mutation, ALK-genfusion, ROS1-genomlejring eller BRAF V600E-mutation skal have udviklet sig efter al standardbehandling målrettet terapi
- Deltagere med rygmarvskompression eller hjernemetastaser skal have modtaget lokal behandling af disse metastaser og forblevet klinisk kontrollerede og asymptomatiske i mindst 7 dage efter stereotaktisk stråling og/eller 14 dage efter helhjernebestråling og før registrering af delstudiet
- Deltagerne skal have modtaget mindst én linje af systemisk behandling for stadium IV eller tilbagevendende NSCLC
- Deltagerne skal have gjort fremskridt (efter den behandlende læges mening) efter den seneste linje af systemisk terapi for NSCLC
- Deltagerne skal være kommet sig (=< grad 1) efter bivirkninger fra tidligere behandling. Undtagelsen er, hvis en bivirkning fra en tidligere behandling vides at være permanent uden forventet yderligere bedring eller opløsning (dvs. endokrinopati fra immunterapi eller cisplatin-neurotoksicitet)
- Deltagerne skal kunne sluge tabletter hele
- Forstudiehistorie og fysisk eksamen skal indhentes inden for 28 dage før delstudieregistrering
- Absolut neutrofiltal (ANC) >= 1.500/uL opnået inden for 28 dage før delstudieregistrering
- Blodpladetal >= 75.000/uL opnået inden for 28 dage før registrering af delstudie
- Hæmoglobin >= 9 g/dL opnået inden for 28 dage før registrering af delstudiet
- Serumbilirubin =< institutionel øvre normalgrænse (IULN) inden for 28 dage før registrering af delstudiet
- Alaninaminotransferase (ALT) og aspartataminotransferase (AST) =< 2 x IULN inden for 28 dage før registrering af delstudiet. For deltagere med levermetastaser, og ALAT og ASAT skal være =< 5 x IULN
- Deltagerne skal have en serumkreatinin =< 1,5 x IULN eller beregnet kreatininclearance >= 50 ml/min ved hjælp af følgende Cockcroft-Gault-formel. Denne prøve skal være tegnet og behandlet inden for 28 dage før registrering af delstudiet
- Deltagere skal have Zubrod præstationsstatus 0-1 dokumenteret inden for 28 dage før delstudieregistrering
- Deltagere med reproduktionspotentiale skal have en negativ serumgraviditetstest inden for 28 dage før registrering af delstudiet
- Deltagerne skal acceptere at få indsendt blodprøver til cirkulerende tumor-DNA (ctDNA)
- Deltagerne skal tilbydes mulighed for at deltage i prøvebanking og i korrelative undersøgelser med henblik på indsamling og fremtidig brug af prøver. Med deltagerens samtykke skal prøver indsamles og indsendes via Southwest Oncology Group (SWOG) prøvesporingssystem
Deltagerne skal informeres om undersøgelsens karakter af denne undersøgelse og skal underskrive og give informeret samtykke i overensstemmelse med institutionelle og føderale retningslinjer
- BEMÆRK: Som en del af registreringsprocessen for Oncology Patient Enrollment Network (OPEN) oplyses den behandlende institutions identitet for at sikre, at den aktuelle (inden for 365 dage) dato for institutionelle revisionsnævns godkendelse af denne undersøgelse er blevet indtastet i systemet
- Som en del af registreringsprocessen for Oncology Patient Enrollment Network (OPEN) oplyses den behandlende institutions identitet for at sikre, at den aktuelle (inden for 365 dage) dato for institutionsbedømmelsesudvalgets godkendelse af denne undersøgelse er blevet indtastet i systemet
- Deltagere med nedsat beslutningsevne er kvalificerede, så længe deres neurologiske eller psykologiske tilstand ikke udelukker deres sikre deltagelse i undersøgelsen (f.eks. sporing af pilleforbrug og rapportering af uønskede hændelser til investigator). For deltagere med svækkede beslutningsevner kan lovligt autoriserede repræsentanter underskrive og give informeret samtykke på vegne af undersøgelsesdeltagere i overensstemmelse med gældende føderale, lokale og Central Institutional Review Board (CIRB) regulativer
Ekskluderingskriterier:
- Deltagere med rygmarvskompression eller hjernemetastaser må ikke have resterende neurologisk dysfunktion, medmindre der ikke forventes yderligere bedring, og deltageren har været stabil på fravænningsdoser af kortikosteroider før delstudieregistrering
- Deltagerne må ikke have leptomeningeal sygdom, medmindre: (1) asymptomatisk og (2) kun påvises ved røntgenbillede (dvs. ikke til stede i cytologi fra cerebral spinalvæske [CSF], hvis CSF udtages)
- Deltagerne må ikke have modtaget nogen tidligere systemisk terapi (systemisk kemoterapi, immunterapi eller forsøgslægemiddel) inden for 21 dage før registrering af delstudiet
- Deltagerne må ikke have modtaget strålebehandling inden for 14 dage før delstudieregistrering, med undtagelse af stereotaktisk stråling til CNS-metastaser, som skal være afsluttet mindst 7 dage før delstudieregistrering
- Deltagerne må ikke have modtaget tidligere AMG 510 eller anden KRAS^G12C-specifik hæmmer
- Deltagerne må ikke planlægge at modtage nogen samtidig kemoterapi, immunterapi, biologisk eller hormonbehandling til cancerbehandling, mens de modtager behandling i denne undersøgelse
- Deltagerne må ikke have gennemgået en større operation inden for 14 dage før delstudieregistrering. Deltageren skal efter den behandlende investigator være fuldt ud restitueret efter virkningerne af en tidligere operation
- Deltagerne må ikke have nogen grad III/IV hjertesygdom som defineret af New York Heart Associations kriterier (dvs. deltagere med hjertesygdom, der resulterer i markant begrænsning af fysisk aktivitet eller resulterer i manglende evne til at udføre fysisk aktivitet uden ubehag), ustabil angina pectoris og myokardieinfarkt inden for 6 måneder eller alvorlig ukontrolleret hjertearytmi
- Deltagerne må ikke have en tidligere eller samtidig malignitet, hvis naturlige historie eller behandling har potentiale til at interferere med sikkerheds- eller effektivitetsvurderingen af undersøgelsesregimet
- Deltagerne må ikke have gastrointestinale lidelser, der kan påvirke lægemiddelabsorptionen
- Deltagerne må ikke have modtaget stærke inducere af CYP3A4 (herunder naturlægemidler såsom perikon) inden for 14 dage før registrering af delstudiet og må ikke planlægge at bruge stærke inducere af CYP3A4 under hele protokolbehandlingen
- Deltagerne må ikke have modtaget CYP3A4-følsomme substrater (med et snævert terapeutisk vindue) inden for 14 dage før delstudieregistrering og må ikke planlægge at bruge CYP3A4-følsomme substrater (med et snævert terapeutisk vindue) under hele protokolbehandlingen
- Deltagerne må ikke være gravide eller ammende. Deltagere med livmoder skal have accepteret at bruge en effektiv præventionsmetode i mindst en måned efter den sidste dosis AMG 510. Deltagere med sæd skal have accepteret at bruge en effektiv præventionsmetode i mindst 3 måneder efter den sidste dosis AMG 510. Deltagerne anses for at være af "reproduktionspotentiale", hvis de har haft menstruation på et hvilket som helst tidspunkt i de foregående 12 på hinanden følgende måneder og ingen tidligere oophorektomi og/eller hysterektomi. Ud over rutinepræventionsmetoder omfatter "effektiv prævention" for deltagere med livmoder også heteroseksuel cølibat og kirurgi beregnet til at forhindre graviditet (eller med en bivirkning af graviditetsforebyggelse) defineret som en hysterektomi, bilateral oophorektomi eller bilateral tubal ligering. Acceptable metoder til prævention for deltagere med sæd omfatter seksuel afholdenhed (afstå fra heteroseksuelt samleje); vasektomi med test, der viser, at der ikke er sæd i sæden; bilateral tubal ligering eller okklusion i partneren; eller et kondom (den kvindelige partner bør også overveje en form for prævention). Men hvis en tidligere cølibatdeltager på noget tidspunkt vælger at blive heteroseksuelt aktiv i løbet af tidsperioden for brug af præventionsforanstaltninger, der er beskrevet i protokollen, er han/hun ansvarlig for at påbegynde præventionsforanstaltninger
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: N/A
- Interventionel model: Enkelt gruppeopgave
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: Behandling (AMG 510)
Patienter modtager AMG 510 PO QD på dag 1-21.
Cykler gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.
|
Givet PO
Andre navne:
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
Svarprocent (bekræftet, fuldstændig eller delvis)
Tidsramme: Op til 3 år
|
Op til 3 år
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Forekomst af uønskede hændelser
Tidsramme: Op til 3 år
|
Hyppigheden og graden af individuelle toksiciteter, der kan tilskrives behandlingen, vil blive estimeret.
|
Op til 3 år
|
|
Progressionsfri overlevelse
Tidsramme: Op til 3 år
|
Vil blive estimeret ved hjælp af metoden fra Kaplan-Meier.
Konfidensintervaller omkring medianer vil blive estimeret ved hjælp af Brookmeyer-Crowley metoden, og omkring skelsættende tidspunkter vil blive beregnet ved hjælp af Greenwoods formel og baseret på en log-log transformation anvendt på overlevelsesfunktionen.
Binære proportioner og tilhørende konfidensintervaller vil blive estimeret inden for kohortemål.
Med deltagere i kohorte 1 og 3 og deltagere i kohorte 2 kan binære proportioner estimeres til inden for henholdsvis 16 % og 20 % med 95 % konfidens.
|
Op til 3 år
|
|
Samlet overlevelse
Tidsramme: Op til 3 år
|
Vil blive estimeret ved hjælp af metoden fra Kaplan-Meier.
Konfidensintervaller omkring medianer vil blive estimeret ved hjælp af Brookmeyer-Crowley metoden, og omkring skelsættende tidspunkter vil blive beregnet ved hjælp af Greenwoods formel og baseret på en log-log transformation anvendt på overlevelsesfunktionen.
Binære proportioner og tilhørende konfidensintervaller vil blive estimeret inden for kohortemål.
Med deltagere i kohorte 1 og 3 og deltagere i kohorte 2 kan binære proportioner estimeres til inden for henholdsvis 16 % og 20 % med 95 % konfidens.
|
Op til 3 år
|
|
Varighed af svar
Tidsramme: Op til 3 år
|
Vil blive estimeret ved hjælp af metoden fra Kaplan-Meier.
Konfidensintervaller omkring medianer vil blive estimeret ved hjælp af Brookmeyer-Crowley metoden, og omkring skelsættende tidspunkter vil blive beregnet ved hjælp af Greenwoods formel og baseret på en log-log transformation anvendt på overlevelsesfunktionen.
Binære proportioner og tilhørende konfidensintervaller vil blive estimeret inden for kohortemål.
Med deltagere i kohorte 1 og 3 og deltagere i kohorte 2 kan binære proportioner estimeres til inden for henholdsvis 16 % og 20 % med 95 % konfidens.
|
Op til 3 år
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Sukhmani K Padda, SWOG Cancer Research Network
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
16. april 2021
Primær færdiggørelse (Anslået)
31. december 2026
Studieafslutning (Anslået)
31. december 2027
Datoer for studieregistrering
Først indsendt
6. november 2020
Først indsendt, der opfyldte QC-kriterier
6. november 2020
Først opslået (Faktiske)
12. november 2020
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Anslået)
5. december 2025
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
4. december 2025
Sidst verificeret
1. december 2025
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Neoplasmer efter sted
- Neoplasmer
- Luftvejssygdomme
- Neoplasmer efter histologisk type
- Lungesygdomme
- Neoplasmer, kirtel og epitel
- Adenocarcinom
- Neoplasmer i luftvejene
- Thoracale neoplasmer
- Karcinom
- Karcinom, bronkogent
- Bronkiale neoplasmer
- Adenocarcinom i lunge
- Lungeneoplasmer
- Karcinom, ikke-småcellet lunge
- Antineoplastiske midler, immunologiske
- Immune Checkpoint-hæmmere
- Antineoplastiske midler
- Molekylære mekanismer for farmakologisk virkning
- Sotorasib
Andre undersøgelses-id-numre
- S1900E (Anden identifikator: CTEP)
- U10CA180888 (U.S. NIH-bevilling/kontrakt)
- NCI-2020-08103 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Ja
Studerer et amerikansk FDA-reguleret enhedsprodukt
Ingen
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
Kliniske forsøg med Lunge Adenocarcinom
-
Seoul National University HospitalAfsluttet
-
Seoul National University HospitalAfsluttet
-
Yonsei UniversityAfsluttetOne Lung VentilationKorea, Republikken
-
Sichuan UniversityWest China HospitalMidlertidigt ikke tilgængeligOne Lung Ventilation
-
Chinese Chronic Respiratory Disease Research NetworkRekruttering
-
Mansoura UniversityAfsluttetOne Lung VentilationEgypten
-
Dokuz Eylul UniversityAfsluttetOne Lung VentilationKalkun
-
Luca BrazziA.O.U. Città della Salute e della Scienza - Molinette HospitalIkke rekrutterer endnuIntubationskomplikation | One Lung Ventilation
-
Ankara Ataturk Sanatorium Training and Research...Ikke rekrutterer endnuOne-lung Ventilation (OLV)Tyrkiet (Türkiye)
-
Joseph D. TobiasAfsluttetOne-lung Ventilation (OLV)Forenede Stater
Kliniske forsøg med Sotorasib
-
Yonsei UniversityIkke rekrutterer endnu
-
AmgenAfsluttetIkke-småcellet lungekræftKina
-
Vestre Viken Hospital TrustOdense University Hospital; Karolinska University Hospital; Oslo University... og andre samarbejdspartnereRekrutteringKræft | Lungekræft | NSCLC trin IV | Mutation | NSCLC, trin III | Lungekræft fase IV | Kræft, lungeNorge
-
Navire Pharma Inc., a BridgeBio companyAmgenAfsluttetIkke småcellet lungekræft | Metastatisk fast tumor | Solid tumor, voksen | Metastatisk NSCLCFrankrig, Spanien, Holland, Australien, Danmark, Grækenland, Italien
-
Gustave Roussy, Cancer Campus, Grand ParisRekrutteringIkke småcellet lungekræft | KRAS P.G12CFrankrig
-
Verastem, Inc.AmgenAktiv, ikke rekrutterendeIkke småcellet lungekræft | KRAS Aktiverende MutationForenede Stater, Spanien, Belgien, Frankrig, Det Forenede Kongerige, Holland
-
Medical University of South CarolinaRain Oncology IncAfsluttetIkke-småcellet lungekræftForenede Stater
-
Vitrac Therapeutics, LLCWestatAfsluttetIkke-småcellet lungekræftForenede Stater
-
Korea University Anam HospitalAktiv, ikke rekrutterende
-
Federation Francophone de Cancerologie DigestiveSpanish Cooperative Group for the Treatment of Digestive Tumours (TTD); Arbeitsgemeinschaft fur Internistische Onkologie og andre samarbejdspartnereIkke rekrutterer endnuKolorektalt karcinom | KRAS G12C mutation | Uansættelig kolorektal kræftSpanien, Italien, Frankrig, Tyskland