Afprøvning af tilføjelsen af et lægemiddel mod kræft, irinotecan, til standardkemoterapibehandlingen (FOLFOX) efter langvarig strålebehandling for avanceret rektalcancer for at forbedre graden af fuldstændig respons og langsigtede organkonserveringsrater (JANUS)
5. september 2025 opdateret af: Alliance for Clinical Trials in Oncology
Janus Rectal Cancer Trial: Et randomiseret fase II forsøg, der tester effektiviteten af triplet versus doublet kemoterapi for at opnå klinisk fuldstændig respons hos patienter med lokalt avanceret rektal cancer
Denne fase II-undersøgelse sammenligner effekten af irinotecan versus oxaliplatin efter langvarig kemoradiation hos patienter med stadium II-III rektalcancer.
Kombinationslægemidler til kemoterapi, såsom FOLFIRINOX (fluorouracil, irinotecan, leucovorin og oxaliplatin), FOLFOX (leucovorin, fluorouracil, oxaliplatin og irinotecan) og CAPOX (capecitabin og oxaliplatin) virker på forskellige måder for at stoppe tumorcellernes vækst. ved at dræbe cellerne, ved at stoppe dem i at dele sig eller ved at stoppe dem i at sprede sig.
FOLFOX eller CAPOX anvendes efter kemoradiation som sædvanlig behandling for endetarmskræft.
Indgivelse af FOLFIRINOX efter kemoradiation kan øge responsraten og føre til højere frekvenser af klinisk fuldstændig respons (med en chance for at undgå operation) sammenlignet med FOLFOX eller CAPOX efter kemoradiation hos patienter med lokalt fremskreden rektalcancer.
Studieoversigt
Status
Aktiv, ikke rekrutterende
Betingelser
Detaljeret beskrivelse
PRIMÆR MÅL:
I. At evaluere og sammenligne de kliniske fuldstændige respons (cCR)-rater hos patienter med lokalt fremskreden rektalcancer behandlet med neoadjuverende lang-kurs neoadjuverende strålebehandling (LCRT) efterfulgt af neoadjuverende modificeret fluorouracil, irinotecan, leucovorin og oxaliplatin (mFOLFIRINOX versus FOLFIRINOX) efterfulgt af neoadjuverende modificeret leucovorin, fluorouracil og oxaliplatin (mFOLFOX6).
SEKUNDÆRE MÅL:
I. At evaluere og sammenligne organbevarelsestid (OPT) mellem to behandlingsarme.
II. At evaluere og sammenligne den sygdomsfrie overlevelsestid (DFS) mellem de to behandlingsarme.
III. At evaluere og sammenligne tid til fjernmetastaser mellem to behandlingsarme.
IV. At evaluere og sammenligne overordnet overlevelse (OS) mellem to behandlingsarme. V. At evaluere og sammenligne toksicitetsprofiler for total neoadjuverende terapi (TNT) mellem to behandlingsarme.
UNDERSØGENDE MÅL:
I. Evaluering af cirkulerende tumor deoxyribonukleinsyre (ctDNA) kinetik under neoadjuverende terapi og overvågning og for at korrelere med radiografiske, patologiske og kliniske resultater.
OVERSIGT: Patienterne randomiseres til 1 ud af 2 arme.
GRUPPE I: Patienter modtager langtidsbehandling med kemoradiation på studiet og modtager derefter enten: FOLFOX-regimen bestående af leucovorin intravenøst (IV), fluorouracil IV og oxaliplatin IV eller CAPOX bestående af capecitabin oralt (PO) og oxaliplatin IV på undersøgelsen. Patienterne gennemgår computertomografi (CT) scanning, magnetisk resonansbilleddannelse (MRI) og bioprøvesamling under hele forsøget. Patienter gennemgår også sigmoidoskopi under hele forsøget og biopsi under screening.
GRUPPE II: Patienter modtager lang-forløb kemoradiationsterapi på studiet og modtager derefter FOLFIRINOX-regimen bestående af leucovorin IV, fluorouracil IV, irinotecan IV og oxaliplatin IV på studiet. Patienterne gennemgår CT-scanning, MR-scanning og blodprøvetagning under hele forsøget. Patienter gennemgår sigmoidoskopi under hele forsøget og biopsi under screening.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
783
Fase
- Fase 2
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Alabama
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Birmingham, Alabama, Forenede Stater, 35233
- University of Alabama at Birmingham Cancer Center
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Mobile, Alabama, Forenede Stater, 36688
- University of South Alabama Mitchell Cancer Institute
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Alaska
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Anchorage, Alaska, Forenede Stater, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, Forenede Stater, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, Forenede Stater, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Forenede Stater, 99508
- Providence Alaska Medical Center
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Arizona
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Kingman, Arizona, Forenede Stater, 86401
- Kingman Regional Medical Center
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Phoenix, Arizona, Forenede Stater, 85054
- Mayo Clinic Hospital in Arizona
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Phoenix, Arizona, Forenede Stater, 85004
- Cancer Center at Saint Joseph's
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Arkansas
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Fort Smith, Arkansas, Forenede Stater, 72903
- Mercy Hospital Fort Smith
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Jonesboro, Arkansas, Forenede Stater, 72401
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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Little Rock, Arkansas, Forenede Stater, 72205
- University of Arkansas for Medical Sciences
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California
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Arroyo Grande, California, Forenede Stater, 93420
- PCR Oncology
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Arroyo Grande, California, Forenede Stater, 93420
- Mission Hope Medical Oncology - Arroyo Grande
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Buena Park, California, Forenede Stater, 90621
- Keck Medicine of USC Buena Park
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Burbank, California, Forenede Stater, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Carmichael, California, Forenede Stater, 95608
- Mercy San Juan Medical Center
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Carmichael, California, Forenede Stater, 95608
- Mercy Cancer Center - Carmichael
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Duarte, California, Forenede Stater, 91010
- City of Hope Comprehensive Cancer Center
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Elk Grove, California, Forenede Stater, 95758
- Mercy Cancer Center - Elk Grove
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Fremont, California, Forenede Stater, 94538
- Washington Hospital
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Irvine, California, Forenede Stater, 92618
- City of Hope at Irvine Lennar
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Irvine, California, Forenede Stater, 92612
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
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Los Angeles, California, Forenede Stater, 90033
- USC / Norris Comprehensive Cancer Center
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Los Angeles, California, Forenede Stater, 90033
- Los Angeles General Medical Center
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Merced, California, Forenede Stater, 95340
- Mercy Cancer Center
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Napa, California, Forenede Stater, 94558
- Providence Queen of The Valley
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Newport Beach, California, Forenede Stater, 92663
- USC Norris Oncology/Hematology-Newport Beach
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Orange, California, Forenede Stater, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
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Orange, California, Forenede Stater, 92868
- Saint Joseph Hospital - Orange
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Rocklin, California, Forenede Stater, 95765
- Mercy Cancer Center - Rocklin
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Sacramento, California, Forenede Stater, 95817
- University of California Davis Comprehensive Cancer Center
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Sacramento, California, Forenede Stater, 95816
- Mercy Cancer Center - Sacramento
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Salinas, California, Forenede Stater, 93901
- Salinas Valley Memorial
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San Luis Obispo, California, Forenede Stater, 93401
- Pacific Central Coast Health Center-San Luis Obispo
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Santa Maria, California, Forenede Stater, 93444
- Mission Hope Medical Oncology - Santa Maria
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Santa Rosa, California, Forenede Stater, 95403
- Providence Medical Foundation - Santa Rosa
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South Pasadena, California, Forenede Stater, 91030
- City of Hope South Pasadena
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St. Helena, California, Forenede Stater, 94574
- Saint Helena Hospital
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Stockton, California, Forenede Stater, 95204
- Saint Joseph's Medical Center
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Torrance, California, Forenede Stater, 90503
- City of Hope South Bay
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Truckee, California, Forenede Stater, 96161
- Gene Upshaw Memorial Tahoe Forest Cancer Center
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Upland, California, Forenede Stater, 91786
- City of Hope Upland
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Walnut Creek, California, Forenede Stater, 94598
- John Muir Medical Center-Walnut Creek
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Woodland, California, Forenede Stater, 95695
- Woodland Memorial Hospital
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Colorado
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Aurora, Colorado, Forenede Stater, 80045
- UCHealth University of Colorado Hospital
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Colorado Springs, Colorado, Forenede Stater, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Forenede Stater, 80909
- UCHealth Memorial Hospital Central
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Colorado Springs, Colorado, Forenede Stater, 80907
- Rocky Mountain Cancer Centers-Penrose
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Colorado Springs, Colorado, Forenede Stater, 80920
- Memorial Hospital North
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Colorado Springs, Colorado, Forenede Stater, 80923
- Saint Francis Cancer Center
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Denver, Colorado, Forenede Stater, 80206
- UCHealth - Cherry Creek
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Denver, Colorado, Forenede Stater, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, Forenede Stater, 80210
- AdventHealth Porter
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Golden, Colorado, Forenede Stater, 80401
- Lutheran Hospital - Cancer Centers of Colorado
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Grand Junction, Colorado, Forenede Stater, 81501
- Saint Mary's Hospital and Regional Medical Center
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Highlands Ranch, Colorado, Forenede Stater, 80129
- UCHealth Highlands Ranch Hospital
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Lakewood, Colorado, Forenede Stater, 80228
- Saint Anthony Hospital
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Littleton, Colorado, Forenede Stater, 80122
- AdventHealth Littleton
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Longmont, Colorado, Forenede Stater, 80501
- Longmont United Hospital
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Parker, Colorado, Forenede Stater, 80138
- AdventHealth Parker
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Pueblo, Colorado, Forenede Stater, 81004
- Saint Mary Corwin Medical Center
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Westminster, Colorado, Forenede Stater, 80023
- Saint Anthony North Hospital
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Wheat Ridge, Colorado, Forenede Stater, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Hartford, Connecticut, Forenede Stater, 06102
- Hartford Hospital
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Meriden, Connecticut, Forenede Stater, 06451
- Midstate Medical Center
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New Britain, Connecticut, Forenede Stater, 06050
- The Hospital of Central Connecticut
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Delaware
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Lewes, Delaware, Forenede Stater, 19958
- Beebe Medical Center
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Millville, Delaware, Forenede Stater, 19967
- Beebe South Coastal Health Campus
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Newark, Delaware, Forenede Stater, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Forenede Stater, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Forenede Stater, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Forenede Stater, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, Forenede Stater, 19971
- Beebe Health Campus
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Wilmington, Delaware, Forenede Stater, 19801
- Christiana Care Health System-Wilmington Hospital
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District of Columbia
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Washington D.C., District of Columbia, Forenede Stater, 20037
- George Washington University Medical Center
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Washington D.C., District of Columbia, Forenede Stater, 20010
- Medstar Washington Hospital Center
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Washington D.C., District of Columbia, Forenede Stater, 20007
- MedStar Georgetown University Hospital
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Florida
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Altamonte Springs, Florida, Forenede Stater, 32701
- AdventHealth Altamonte
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Aventura, Florida, Forenede Stater, 33180
- Mount Sinai Comprehensive Cancer Center at Aventura
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Celebration, Florida, Forenede Stater, 34747
- AdventHealth Celebration
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Clearwater, Florida, Forenede Stater, 33756
- Morton Plant Hospital
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Fort Lauderdale, Florida, Forenede Stater, 33308
- Holy Cross Hospital
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Gainesville, Florida, Forenede Stater, 32610
- University of Florida Health Science Center - Gainesville
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Hollywood, Florida, Forenede Stater, 33021
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital
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Jacksonville, Florida, Forenede Stater, 32224-9980
- Mayo Clinic in Florida
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Kissimmee, Florida, Forenede Stater, 34744
- AdventHealth Kissimmee
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Lutz, Florida, Forenede Stater, 33558
- Saint Joseph's Hospital-North
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Miami Beach, Florida, Forenede Stater, 33140
- Mount Sinai Medical Center
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Orlando, Florida, Forenede Stater, 32803
- AdventHealth Orlando
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Orlando, Florida, Forenede Stater, 32822
- AdventHealth East Orlando
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Pembroke Pines, Florida, Forenede Stater, 33028
- Memorial Hospital West
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St. Petersburg, Florida, Forenede Stater, 33705
- Saint Anthony's Hospital Cancer Care Center
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Tampa, Florida, Forenede Stater, 33606
- Tampa General Hospital
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Tampa, Florida, Forenede Stater, 33607
- Saint Joseph's Hospital/Children's Hospital-Tampa
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Georgia
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Atlanta, Georgia, Forenede Stater, 30308
- Emory University Hospital Midtown
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Atlanta, Georgia, Forenede Stater, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, Forenede Stater, 30342
- Emory Saint Joseph's Hospital
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Decatur, Georgia, Forenede Stater, 30033
- Emory Decatur Hospital
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Johns Creek, Georgia, Forenede Stater, 30097
- Emory Johns Creek Hospital
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Savannah, Georgia, Forenede Stater, 31404
- Memorial Health University Medical Center
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Hawaii
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Honolulu, Hawaii, Forenede Stater, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Forenede Stater, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Forenede Stater, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Forenede Stater, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, Forenede Stater, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Forenede Stater, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Forenede Stater, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Forenede Stater, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Forenede Stater, 96826
- Kapiolani Medical Center for Women and Children
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Kailua, Hawaii, Forenede Stater, 96734
- Castle Medical Center
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Lihue, Hawaii, Forenede Stater, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, Forenede Stater, 96701
- Hawaii Cancer Care - Westridge
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‘Aiea, Hawaii, Forenede Stater, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, Forenede Stater, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, Forenede Stater, 96701
- The Cancer Center of Hawaii-Pali Momi
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‘Ewa Beach, Hawaii, Forenede Stater, 96706
- The Queen's Medical Center - West Oahu
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Idaho
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Boise, Idaho, Forenede Stater, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, Forenede Stater, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, Forenede Stater, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, Forenede Stater, 83814
- Kootenai Health - Coeur d'Alene
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Fruitland, Idaho, Forenede Stater, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, Forenede Stater, 83642
- Idaho Urologic Institute-Meridian
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Meridian, Idaho, Forenede Stater, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, Forenede Stater, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Nampa, Idaho, Forenede Stater, 83687
- Saint Luke's Cancer Institute - Nampa
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Post Falls, Idaho, Forenede Stater, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Twin Falls, Idaho, Forenede Stater, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Alton, Illinois, Forenede Stater, 62002
- OSF Saint Anthony's Health Center
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Aurora, Illinois, Forenede Stater, 60504
- Rush-Copley Medical Center
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Aurora, Illinois, Forenede Stater, 60506
- Advocate Outpatient Center - Aurora
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Barrington, Illinois, Forenede Stater, 60010
- Advocate Good Shepherd Hospital
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Bloomington, Illinois, Forenede Stater, 61704
- Illinois CancerCare-Bloomington
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Bloomington, Illinois, Forenede Stater, 61701
- OSF Saint Joseph Medical Center
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Canton, Illinois, Forenede Stater, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, Forenede Stater, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, Forenede Stater, 62918
- SIH Cancer Institute
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Carthage, Illinois, Forenede Stater, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Forenede Stater, 62801
- Centralia Oncology Clinic
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Centralia, Illinois, Forenede Stater, 62801
- Saint Mary's Hospital
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Chicago, Illinois, Forenede Stater, 60611
- Northwestern University
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Chicago, Illinois, Forenede Stater, 60637
- University of Chicago Comprehensive Cancer Center
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Chicago, Illinois, Forenede Stater, 60612
- John H Stroger Jr Hospital of Cook County
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Chicago, Illinois, Forenede Stater, 60657
- Advocate Illinois Masonic Medical Center
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Crystal Lake, Illinois, Forenede Stater, 60014
- AMG Crystal Lake - Oncology
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Danville, Illinois, Forenede Stater, 61832
- Carle at The Riverfront
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DeKalb, Illinois, Forenede Stater, 60115
- Northwestern Medicine Cancer Center Kishwaukee
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Decatur, Illinois, Forenede Stater, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Forenede Stater, 62526
- Cancer Care Specialists of Illinois - Decatur
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Dixon, Illinois, Forenede Stater, 61021
- Illinois CancerCare-Dixon
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Downers Grove, Illinois, Forenede Stater, 60515
- Advocate Good Samaritan Hospital
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Effingham, Illinois, Forenede Stater, 62401
- Crossroads Cancer Center
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Effingham, Illinois, Forenede Stater, 62401
- Carle Physician Group-Effingham
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Elgin, Illinois, Forenede Stater, 60123
- Advocate Sherman Hospital
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Elmhurst, Illinois, Forenede Stater, 60126
- Elmhurst Memorial Hospital
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Eureka, Illinois, Forenede Stater, 61530
- Illinois CancerCare-Eureka
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Galesburg, Illinois, Forenede Stater, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, Forenede Stater, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, Forenede Stater, 60134
- Northwestern Medicine Cancer Center Delnor
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Glenview, Illinois, Forenede Stater, 60026
- Northwestern Medicine Glenview Outpatient Center
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Grayslake, Illinois, Forenede Stater, 60030
- Northwestern Medicine Grayslake Outpatient Center
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Harvey, Illinois, Forenede Stater, 60426
- Ingalls Memorial Hospital
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Hazel Crest, Illinois, Forenede Stater, 60429
- Advocate South Suburban Hospital
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Kewanee, Illinois, Forenede Stater, 61443
- Illinois CancerCare-Kewanee Clinic
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Lake Forest, Illinois, Forenede Stater, 60045
- Northwestern Medicine Lake Forest Hospital
-
Libertyville, Illinois, Forenede Stater, 60048
- Condell Memorial Hospital
-
Libertyville, Illinois, Forenede Stater, 60048
- AMG Libertyville - Oncology
-
Macomb, Illinois, Forenede Stater, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, Forenede Stater, 61938
- Carle Physician Group-Mattoon/Charleston
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Mount Vernon, Illinois, Forenede Stater, 62864
- SSM Health Good Samaritan
-
Naperville, Illinois, Forenede Stater, 60540
- Edward Hospital/Cancer Center
-
New Lenox, Illinois, Forenede Stater, 60451
- UC Comprehensive Cancer Center at Silver Cross
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Normal, Illinois, Forenede Stater, 61761
- Carle Cancer Institute Normal
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Normal, Illinois, Forenede Stater, 61761
- Carle BroMenn Medical Center
-
O'Fallon, Illinois, Forenede Stater, 62269
- Cancer Care Center of O'Fallon
-
O'Fallon, Illinois, Forenede Stater, 62269
- HSHS Saint Elizabeth's Hospital
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Oak Lawn, Illinois, Forenede Stater, 60453-2699
- Advocate Christ Medical Center
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Orland Park, Illinois, Forenede Stater, 60462
- University of Chicago Medicine-Orland Park
-
Ottawa, Illinois, Forenede Stater, 61350
- Illinois CancerCare-Ottawa Clinic
-
Palos Heights, Illinois, Forenede Stater, 60463
- Advocate High Tech Medical Park
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Park Ridge, Illinois, Forenede Stater, 60068
- Advocate Lutheran General Hospital
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Pekin, Illinois, Forenede Stater, 61554
- Illinois CancerCare-Pekin
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Peoria, Illinois, Forenede Stater, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Forenede Stater, 61615
- Illinois CancerCare-Peoria
-
Peru, Illinois, Forenede Stater, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Forenede Stater, 61354
- Valley Radiation Oncology
-
Plainfield, Illinois, Forenede Stater, 60585
- Edward Hospital/Cancer Center?Plainfield
-
Princeton, Illinois, Forenede Stater, 61356
- Illinois CancerCare-Princeton
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Springfield, Illinois, Forenede Stater, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Forenede Stater, 62702
- Springfield Clinic
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Springfield, Illinois, Forenede Stater, 62781
- Springfield Memorial Hospital
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Urbana, Illinois, Forenede Stater, 61801
- Carle Cancer Center
-
Warrenville, Illinois, Forenede Stater, 60555
- Northwestern Medicine Cancer Center Warrenville
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Washington, Illinois, Forenede Stater, 61571
- Illinois CancerCare - Washington
-
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Indiana
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Crown Point, Indiana, Forenede Stater, 46307
- Northwest Cancer Center - Main Campus
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Dyer, Indiana, Forenede Stater, 46311
- Northwest Oncology LLC
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Fort Wayne, Indiana, Forenede Stater, 46845
- Parkview Regional Medical Center
-
Hobart, Indiana, Forenede Stater, 46342
- Northwest Cancer Center - Hobart
-
Hobart, Indiana, Forenede Stater, 46342
- Saint Mary Medical Center
-
Munster, Indiana, Forenede Stater, 46321
- The Community Hospital
-
Munster, Indiana, Forenede Stater, 46321
- Women's Diagnostic Center - Munster
-
New Albany, Indiana, Forenede Stater, 47150
- Baptist Health Floyd
-
Richmond, Indiana, Forenede Stater, 47374
- Reid Health
-
Valparaiso, Indiana, Forenede Stater, 46383
- Northwest Cancer Center - Valparaiso
-
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Iowa
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Ankeny, Iowa, Forenede Stater, 50023
- UI Health Care Mission Cancer and Blood - Ankeny Clinic
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Oncology Associates at Mercy Medical Center
-
Clive, Iowa, Forenede Stater, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Forenede Stater, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Creston, Iowa, Forenede Stater, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, Forenede Stater, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Forenede Stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forenede Stater, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Forenede Stater, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Waukee, Iowa, Forenede Stater, 50263
- UI Health Care Mission Cancer and Blood - Waukee Clinic
-
West Des Moines, Iowa, Forenede Stater, 50266
- Mercy Medical Center-West Lakes
-
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Kansas
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Garden City, Kansas, Forenede Stater, 67846
- Central Care Cancer Center - Garden City
-
Great Bend, Kansas, Forenede Stater, 67530
- Central Care Cancer Center - Great Bend
-
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Kentucky
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Corbin, Kentucky, Forenede Stater, 40701
- Baptist Health Corbin
-
Edgewood, Kentucky, Forenede Stater, 41017
- Saint Elizabeth Healthcare Edgewood
-
Fort Thomas, Kentucky, Forenede Stater, 41075
- Saint Elizabeth Healthcare Fort Thomas
-
Lexington, Kentucky, Forenede Stater, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, Forenede Stater, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Forenede Stater, 40509
- Saint Joseph Hospital East
-
Lexington, Kentucky, Forenede Stater, 40503
- Baptist Health Lexington
-
Lexington, Kentucky, Forenede Stater, 40504
- Saint Joseph Hospital
-
Lexington, Kentucky, Forenede Stater, 40509
- Baptist Health Hamburg
-
Louisville, Kentucky, Forenede Stater, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Forenede Stater, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Forenede Stater, 40207
- Baptist Health Louisville
-
Paducah, Kentucky, Forenede Stater, 42003
- Baptist Health Paducah
-
-
Louisiana
-
Covington, Louisiana, Forenede Stater, 70433
- Ochsner Hematology Oncology North Shore - Covington (West Region)
-
New Orleans, Louisiana, Forenede Stater, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, Forenede Stater, 70112
- University Medical Center New Orleans
-
-
Maine
-
Brewer, Maine, Forenede Stater, 04412
- Lafayette Family Cancer Center-EMMC
-
-
Maryland
-
Baltimore, Maryland, Forenede Stater, 21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
-
Baltimore, Maryland, Forenede Stater, 21215
- Sinai Hospital of Baltimore
-
Baltimore, Maryland, Forenede Stater, 21239
- MedStar Good Samaritan Hospital
-
Cumberland, Maryland, Forenede Stater, 21502
- UPMC Western Maryland
-
Westminster, Maryland, Forenede Stater, 21157
- William E Kahlert Regional Cancer Center/Sinai Hospital
-
-
Massachusetts
-
Boston, Massachusetts, Forenede Stater, 02215
- Beth Israel Deaconess Medical Center
-
Boston, Massachusetts, Forenede Stater, 02215
- Dana-Farber Cancer Institute
-
Boston, Massachusetts, Forenede Stater, 02118
- Boston Medical Center
-
Burlington, Massachusetts, Forenede Stater, 01805
- Lahey Hospital and Medical Center
-
Foxborough, Massachusetts, Forenede Stater, 02035
- Dana-Farber Cancer Institute at Foxborough
-
Methuen, Massachusetts, Forenede Stater, 01844
- Dana Farber-Merrimack Valley
-
Milford, Massachusetts, Forenede Stater, 01757
- Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
-
Peabody, Massachusetts, Forenede Stater, 01960
- Lahey Medical Center-Peabody
-
South Weymouth, Massachusetts, Forenede Stater, 02190
- Dana-Farber/Brigham and Women's Cancer Center at South Shore
-
-
Michigan
-
Ann Arbor, Michigan, Forenede Stater, 48109
- University of Michigan Comprehensive Cancer Center
-
Ann Arbor, Michigan, Forenede Stater, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Brighton, Michigan, Forenede Stater, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, Forenede Stater, 48116
- University of Michigan - Brighton Center for Specialty Care
-
Brighton, Michigan, Forenede Stater, 48114
- Trinity Health Medical Center - Brighton
-
Brownstown, Michigan, Forenede Stater, 48183
- Henry Ford Cancer Institute-Downriver
-
Canton, Michigan, Forenede Stater, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, Forenede Stater, 48188
- Trinity Health Medical Center - Canton
-
Caro, Michigan, Forenede Stater, 48723
- Caro Cancer Center
-
Chelsea, Michigan, Forenede Stater, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, Forenede Stater, 48118
- Chelsea Hospital
-
Clinton Township, Michigan, Forenede Stater, 48038
- Henry Ford Macomb Hospital-Clinton Township
-
Dearborn, Michigan, Forenede Stater, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, Forenede Stater, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Forenede Stater, 48236
- Henry Ford Health Saint John Hospital
-
Farmington Hills, Michigan, Forenede Stater, 48336
- Corewell Health Farmington Hills Hospital
-
Flint, Michigan, Forenede Stater, 48503
- Hurley Medical Center
-
Flint, Michigan, Forenede Stater, 48503
- Genesys Hurley Cancer Institute
-
Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Henry Ford Saint John Hospital - Van Elslander
-
Jackson, Michigan, Forenede Stater, 49201
- Allegiance Health
-
Lansing, Michigan, Forenede Stater, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Forenede Stater, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Macomb, Michigan, Forenede Stater, 48044
- Henry Ford Saint John Hospital - Macomb Medical
-
Marlette, Michigan, Forenede Stater, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Midland, Michigan, Forenede Stater, 48670
- MyMichigan Medical Center Midland
-
Novi, Michigan, Forenede Stater, 48377
- Henry Ford Medical Center-Columbus
-
Novi, Michigan, Forenede Stater, 48374
- Henry Ford Health Providence Novi Hospital
-
Pontiac, Michigan, Forenede Stater, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Pontiac, Michigan, Forenede Stater, 48341
- Michigan Healthcare Professionals Pontiac
-
Royal Oak, Michigan, Forenede Stater, 48073
- Corewell Health William Beaumont University Hospital
-
Saginaw, Michigan, Forenede Stater, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saginaw, Michigan, Forenede Stater, 48601
- MyMichigan Medical Center Saginaw
-
Southfield, Michigan, Forenede Stater, 48075
- Henry Ford Health Providence Southfield Hospital
-
Tawas City, Michigan, Forenede Stater, 48764
- MyMichigan Medical Center Tawas
-
Troy, Michigan, Forenede Stater, 48085
- Corewell Health Beaumont Troy Hospital
-
Warren, Michigan, Forenede Stater, 48093
- Henry Ford Health Warren Hospital
-
West Bloomfield, Michigan, Forenede Stater, 48322
- Henry Ford West Bloomfield Hospital
-
West Branch, Michigan, Forenede Stater, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Ypsilanti, Michigan, Forenede Stater, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
-
Minnesota
-
Bemidji, Minnesota, Forenede Stater, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Forenede Stater, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Forenede Stater, 55337
- Minnesota Oncology - Burnsville
-
Coon Rapids, Minnesota, Forenede Stater, 55433
- Mercy Hospital
-
Deer River, Minnesota, Forenede Stater, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, Forenede Stater, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Forenede Stater, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Forenede Stater, 55435
- Fairview Southdale Hospital
-
Fosston, Minnesota, Forenede Stater, 56542
- Essentia Health - Fosston
-
Hibbing, Minnesota, Forenede Stater, 55746
- Essentia Health Hibbing Clinic
-
Maple Grove, Minnesota, Forenede Stater, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Forenede Stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forenede Stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forenede Stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Forenede Stater, 55454
- Health Partners Inc
-
Monticello, Minnesota, Forenede Stater, 55362
- Monticello Cancer Center
-
Park Rapids, Minnesota, Forenede Stater, 56470
- Essentia Health - Park Rapids
-
Robbinsdale, Minnesota, Forenede Stater, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Forenede Stater, 55905
- Mayo Clinic in Rochester
-
Saint Cloud, Minnesota, Forenede Stater, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Forenede Stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forenede Stater, 55102
- United Hospital
-
Sandstone, Minnesota, Forenede Stater, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, Forenede Stater, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Forenede Stater, 55082
- Lakeview Hospital
-
Virginia, Minnesota, Forenede Stater, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, Forenede Stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forenede Stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forenede Stater, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Mississippi
-
Columbus, Mississippi, Forenede Stater, 39705
- Baptist Memorial Hospital and Cancer Center-Golden Triangle
-
Grenada, Mississippi, Forenede Stater, 38901
- Baptist Cancer Center-Grenada
-
New Albany, Mississippi, Forenede Stater, 38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford, Mississippi, Forenede Stater, 38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Southhaven, Mississippi, Forenede Stater, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Bolivar, Missouri, Forenede Stater, 65613
- Central Care Cancer Center - Bolivar
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Mercy Cancer Center - Cape Girardeau
-
Farmington, Missouri, Forenede Stater, 63640
- Parkland Health Center - Farmington
-
Jefferson City, Missouri, Forenede Stater, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Forenede Stater, 64804
- Freeman Health System
-
Joplin, Missouri, Forenede Stater, 64804
- Mercy Hospital Joplin
-
Osage Beach, Missouri, Forenede Stater, 65065
- Lake Regional Hospital
-
Rolla, Missouri, Forenede Stater, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Forenede Stater, 65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph, Missouri, Forenede Stater, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, Forenede Stater, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Forenede Stater, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Forenede Stater, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Forenede Stater, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Forenede Stater, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, Forenede Stater, 63128
- Mercy Hospital South
-
Sullivan, Missouri, Forenede Stater, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, Forenede Stater, 63127
- BJC Outpatient Center at Sunset Hills
-
-
Montana
-
Billings, Montana, Forenede Stater, 59101
- Billings Clinic Cancer Center
-
Bozeman, Montana, Forenede Stater, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Forenede Stater, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Forenede Stater, 59405
- Great Falls Clinic
-
Great Falls, Montana, Forenede Stater, 59405
- Benefis Sletten Cancer Institute
-
Havre, Montana, Forenede Stater, 59501
- Hi-Line Sletten Cancer Center
-
Kalispell, Montana, Forenede Stater, 59901
- Logan Health Medical Center
-
Missoula, Montana, Forenede Stater, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Forenede Stater, 59804
- Community Medical Center
-
-
Nebraska
-
Kearney, Nebraska, Forenede Stater, 68847
- CHI Health Good Samaritan
-
Omaha, Nebraska, Forenede Stater, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Forenede Stater, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Forenede Stater, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Forenede Stater, 68131
- Creighton University Medical Center
-
-
Nevada
-
Henderson, Nevada, Forenede Stater, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- OptumCare Cancer Care at Seven Hills
-
Las Vegas, Nevada, Forenede Stater, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Forenede Stater, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Forenede Stater, 89109
- GenesisCare USA - Las Vegas
-
Las Vegas, Nevada, Forenede Stater, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Forenede Stater, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Forenede Stater, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Forenede Stater, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Forenede Stater, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Forenede Stater, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Forenede Stater, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Forenede Stater, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, Forenede Stater, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Forenede Stater, 89148
- GenesisCare USA - Fort Apache
-
Reno, Nevada, Forenede Stater, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Forenede Stater, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Forenede Stater, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Concord, New Hampshire, Forenede Stater, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Lebanon, New Hampshire, Forenede Stater, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
Londonderry, New Hampshire, Forenede Stater, 03053
- The Dana-Farber Cancer Institute at Londonderry
-
Manchester, New Hampshire, Forenede Stater, 03103
- Solinsky Center for Cancer Care
-
-
New Jersey
-
Basking Ridge, New Jersey, Forenede Stater, 07920
- Memorial Sloan Kettering Basking Ridge
-
Camden, New Jersey, Forenede Stater, 08103
- Cooper Hospital University Medical Center
-
Cherry Hill, New Jersey, Forenede Stater, 08002
- Jefferson Cherry Hill Hospital
-
Middletown, New Jersey, Forenede Stater, 07748
- Memorial Sloan Kettering Monmouth
-
Montvale, New Jersey, Forenede Stater, 07645
- Memorial Sloan Kettering Bergen
-
Morristown, New Jersey, Forenede Stater, 07960
- Morristown Medical Center
-
Paramus, New Jersey, Forenede Stater, 07652
- The Valley Hospital - Luckow Pavilion
-
Pompton, New Jersey, Forenede Stater, 07444
- Chilton Medical Center
-
Ridgewood, New Jersey, Forenede Stater, 07450
- Valley Health System Ridgewood Campus
-
Sewell, New Jersey, Forenede Stater, 08080
- Sidney Kimmel Cancer Center Washington Township
-
Summit, New Jersey, Forenede Stater, 07902
- Overlook Hospital
-
Teaneck, New Jersey, Forenede Stater, 07666
- Holy Name Hospital
-
Westwood, New Jersey, Forenede Stater, 07675
- Valley Health System-Hematology/Oncology
-
-
New Mexico
-
Albuquerque, New Mexico, Forenede Stater, 87106
- University of New Mexico Cancer Center
-
-
New York
-
Brooklyn, New York, Forenede Stater, 11215
- New York-Presbyterian/Brooklyn Methodist Hospital
-
Brooklyn, New York, Forenede Stater, 11220
- NYU Langone Hospital - Brooklyn
-
Buffalo, New York, Forenede Stater, 14263
- Roswell Park Cancer Institute
-
Commack, New York, Forenede Stater, 11725
- Memorial Sloan Kettering Commack
-
Flushing, New York, Forenede Stater, 11355
- The New York Hospital Medical Center of Queens
-
Forest Hills, New York, Forenede Stater, 11375
- Northwell Health Physicians Partners Radiation Medicine at Queens
-
Glens Falls, New York, Forenede Stater, 12801
- Glens Falls Hospital
-
Greenlawn, New York, Forenede Stater, 11740
- Northwell Health Cancer Institute at Huntington
-
Harrison, New York, Forenede Stater, 10604
- Memorial Sloan Kettering Westchester
-
Lake Success, New York, Forenede Stater, 11042
- Northwell Health/Center for Advanced Medicine
-
Manhasset, New York, Forenede Stater, 11030
- North Shore University Hospital
-
Middletown, New York, Forenede Stater, 10940
- Garnet Health Medical Center
-
Mineola, New York, Forenede Stater, 11501
- NYU Langone Hospital - Long Island
-
Mount Kisco, New York, Forenede Stater, 10549
- Northern Westchester Hospital
-
New Hyde Park, New York, Forenede Stater, 11040
- Long Island Jewish Medical Center
-
New York, New York, Forenede Stater, 10065
- Memorial Sloan Kettering Cancer Center
-
New York, New York, Forenede Stater, 10019
- Mount Sinai West
-
New York, New York, Forenede Stater, 10029
- Mount Sinai Hospital
-
New York, New York, Forenede Stater, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
New York, New York, Forenede Stater, 10065
- NYP/Weill Cornell Medical Center
-
New York, New York, Forenede Stater, 10016
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
-
New York, New York, Forenede Stater, 10075
- Lenox Hill Hospital
-
New York, New York, Forenede Stater, 10065
- Manhattan Eye Ear and Throat Hospital
-
Oswego, New York, Forenede Stater, 13126
- Upstate Cancer Center at Oswego
-
Rego Park, New York, Forenede Stater, 11374
- Queens Cancer Center
-
Rochester, New York, Forenede Stater, 14642
- University of Rochester
-
Sleepy Hollow, New York, Forenede Stater, 10591
- Phelps Memorial Hospital Center
-
Syracuse, New York, Forenede Stater, 13210
- State University of New York Upstate Medical University
-
Syracuse, New York, Forenede Stater, 13215
- SUNY Upstate Medical Center-Community Campus
-
The Bronx, New York, Forenede Stater, 10461
- Montefiore Medical Center-Einstein Campus
-
The Bronx, New York, Forenede Stater, 10467
- Montefiore Medical Center - Moses Campus
-
The Bronx, New York, Forenede Stater, 10461
- Montefiore Medical Center-Weiler Hospital
-
Uniondale, New York, Forenede Stater, 11553
- Memorial Sloan Kettering Nassau
-
Verona, New York, Forenede Stater, 13478
- Upstate Cancer Center at Verona
-
Webster, New York, Forenede Stater, 14580
- Wilmot Cancer Institute at Webster
-
-
North Carolina
-
Albemarle, North Carolina, Forenede Stater, 28002
- Atrium Health Stanly/LCI-Albemarle
-
Cary, North Carolina, Forenede Stater, 27518
- Duke Cancer Center Cary
-
Chapel Hill, North Carolina, Forenede Stater, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Charlotte, North Carolina, Forenede Stater, 28203
- Carolinas Medical Center/Levine Cancer Institute
-
Charlotte, North Carolina, Forenede Stater, 28210
- Atrium Health Pineville/LCI-Pineville
-
Charlotte, North Carolina, Forenede Stater, 28262
- Atrium Health University City/LCI-University
-
Charlotte, North Carolina, Forenede Stater, 28211
- Levine Cancer Institute-SouthPark
-
Charlotte, North Carolina, Forenede Stater, 28277
- Levine Cancer Institute-Ballantyne
-
Clemmons, North Carolina, Forenede Stater, 27012
- Wake Forest University at Clemmons
-
Concord, North Carolina, Forenede Stater, 28025
- Atrium Health Cabarrus/LCI-Concord
-
Durham, North Carolina, Forenede Stater, 27710
- Duke University Medical Center
-
Forest City, North Carolina, Forenede Stater, 28043
- Levine Cancer Institute - Rutherford
-
Gastonia, North Carolina, Forenede Stater, 28054
- Levine Cancer Institute-Gaston
-
Greenville, North Carolina, Forenede Stater, 27834
- East Carolina University
-
High Point, North Carolina, Forenede Stater, 27262
- Hayworth Cancer Center
-
Hillsborough, North Carolina, Forenede Stater, 27278
- University of North Carolina-Hillsborough Campus
-
Lincolnton, North Carolina, Forenede Stater, 28092
- Atrium Health Lincoln/LCI-Lincolnton
-
Matthews, North Carolina, Forenede Stater, 28104
- Levine Cancer Institute - Union West
-
Monroe, North Carolina, Forenede Stater, 28112
- Atrium Health Union/LCI-Union
-
Raleigh, North Carolina, Forenede Stater, 27609
- Duke Cancer Center Raleigh
-
Shelby, North Carolina, Forenede Stater, 28150
- Atrium Health Cleveland/LCI-Cleveland
-
Wilkesboro, North Carolina, Forenede Stater, 28659
- Wake Forest Baptist Health - Wilkes Medical Center
-
Winston-Salem, North Carolina, Forenede Stater, 27157
- Wake Forest University Health Sciences
-
-
North Dakota
-
Bismarck, North Dakota, Forenede Stater, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Forenede Stater, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Broadway Medical Center
-
Jamestown, North Dakota, Forenede Stater, 58401
- Essentia Health - Jamestown Clinic
-
-
Ohio
-
Beavercreek, Ohio, Forenede Stater, 45431
- Indu and Raj Soin Medical Center
-
Boardman, Ohio, Forenede Stater, 44512
- Saint Elizabeth Boardman Hospital
-
Canton, Ohio, Forenede Stater, 44710
- Aultman Health Foundation
-
Centerville, Ohio, Forenede Stater, 45459
- Dayton Physicians LLC-Miami Valley South
-
Cincinnati, Ohio, Forenede Stater, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Forenede Stater, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Forenede Stater, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cleveland, Ohio, Forenede Stater, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, Forenede Stater, 43210
- Ohio State University Comprehensive Cancer Center
-
Dayton, Ohio, Forenede Stater, 45415
- Dayton Physician LLC - Englewood
-
Findlay, Ohio, Forenede Stater, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Forenede Stater, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Forenede Stater, 45840
- Orion Cancer Care
-
Franklin, Ohio, Forenede Stater, 45005
- Dayton Physicians LLC-Atrium
-
Greenville, Ohio, Forenede Stater, 45331
- Wayne Hospital
-
Greenville, Ohio, Forenede Stater, 45331
- Dayton Physicians LLC-Wayne
-
Kettering, Ohio, Forenede Stater, 45429
- Kettering Medical Center
-
Kettering, Ohio, Forenede Stater, 45409
- Greater Dayton Cancer Center
-
Troy, Ohio, Forenede Stater, 45373
- Dayton Physicians LLC - Troy
-
Warren, Ohio, Forenede Stater, 44484
- Saint Joseph Warren Hospital
-
Youngstown, Ohio, Forenede Stater, 44501
- Saint Elizabeth Youngstown Hospital
-
-
Oklahoma
-
Oklahoma City, Oklahoma, Forenede Stater, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Forenede Stater, 73120
- Mercy Hospital Oklahoma City
-
-
Oregon
-
Bend, Oregon, Forenede Stater, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Forenede Stater, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Forenede Stater, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Forenede Stater, 97420
- Bay Area Hospital
-
Gresham, Oregon, Forenede Stater, 97030
- Legacy Mount Hood Medical Center
-
Newberg, Oregon, Forenede Stater, 97132
- Providence Newberg Medical Center
-
Oregon City, Oregon, Forenede Stater, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, Forenede Stater, 97210
- Legacy Good Samaritan Hospital and Medical Center
-
Portland, Oregon, Forenede Stater, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Forenede Stater, 97225
- Providence Saint Vincent Medical Center
-
Tualatin, Oregon, Forenede Stater, 97062
- Legacy Meridian Park Hospital
-
-
Pennsylvania
-
Allentown, Pennsylvania, Forenede Stater, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Altoona, Pennsylvania, Forenede Stater, 16601
- UPMC Altoona
-
Beaver, Pennsylvania, Forenede Stater, 15009
- UPMC-Heritage Valley Health System Beaver
-
Bethlehem, Pennsylvania, Forenede Stater, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Camp Hill, Pennsylvania, Forenede Stater, 17011
- UPMC Camp Hill
-
Carlisle, Pennsylvania, Forenede Stater, 17015
- Carlisle Regional Cancer Center
-
Chadds Ford, Pennsylvania, Forenede Stater, 19317
- Christiana Care Health System-Concord Health Center
-
East Stroudsburg, Pennsylvania, Forenede Stater, 18301
- Pocono Medical Center
-
Erie, Pennsylvania, Forenede Stater, 16505
- UPMC Hillman Cancer Center Erie
-
Erie, Pennsylvania, Forenede Stater, 16544
- Saint Vincent Hospital
-
Farrell, Pennsylvania, Forenede Stater, 16121
- UPMC Cancer Center at UPMC Horizon
-
Greensburg, Pennsylvania, Forenede Stater, 15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Greenville, Pennsylvania, Forenede Stater, 16125
- UPMC Hillman Cancer Center in Greenville/UPMC Horizon
-
Harrisburg, Pennsylvania, Forenede Stater, 17109
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Hershey, Pennsylvania, Forenede Stater, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Indiana, Pennsylvania, Forenede Stater, 15701
- IRMC Cancer Center
-
Jefferson Hills, Pennsylvania, Forenede Stater, 15025
- Jefferson Hospital
-
Johnstown, Pennsylvania, Forenede Stater, 15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
McKeesport, Pennsylvania, Forenede Stater, 15132
- UPMC Cancer Center at UPMC McKeesport
-
Mechanicsburg, Pennsylvania, Forenede Stater, 17050
- UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
-
Monroeville, Pennsylvania, Forenede Stater, 15146
- Forbes Hospital
-
Monroeville, Pennsylvania, Forenede Stater, 15146
- UPMC Hillman Cancer Center - Monroeville
-
Monroeville, Pennsylvania, Forenede Stater, 15146
- UPMC Cancer Center - Monroeville
-
Moon Township, Pennsylvania, Forenede Stater, 15108
- UPMC Hillman Cancer Center in Coraopolis
-
Mount Pleasant, Pennsylvania, Forenede Stater, 15666
- UPMC Hillman Cancer Center - Part of Frick Hospital
-
N. Huntingdon, Pennsylvania, Forenede Stater, 15642
- Arnold Palmer Cancer Center Medical Oncology Norwin
-
Natrona Heights, Pennsylvania, Forenede Stater, 15065
- UPMC Cancer Center-Natrona Heights
-
New Castle, Pennsylvania, Forenede Stater, 16105
- UPMC Hillman Cancer Center - New Castle
-
Philadelphia, Pennsylvania, Forenede Stater, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19114
- Jefferson Torresdale Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15212
- Allegheny General Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15224
- West Penn Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15213
- UPMC-Magee Womens Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15232
- University of Pittsburgh Cancer Institute (UPCI)
-
Pittsburgh, Pennsylvania, Forenede Stater, 15232
- UPMC-Shadyside Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15215
- UPMC-Saint Margaret
-
Pittsburgh, Pennsylvania, Forenede Stater, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pittsburgh, Pennsylvania, Forenede Stater, 15219
- UPMC-Mercy Hospital
-
Seneca, Pennsylvania, Forenede Stater, 16346
- UPMC Cancer Center at UPMC Northwest
-
Uniontown, Pennsylvania, Forenede Stater, 15401
- UPMC Uniontown Hospital Radiation Oncology
-
Uniontown, Pennsylvania, Forenede Stater, 15401
- UPMC Cancer Center-Uniontown
-
Washington, Pennsylvania, Forenede Stater, 15301
- UPMC Washington Hospital Radiation Oncology
-
Washington, Pennsylvania, Forenede Stater, 15301
- UPMC Cancer Center-Washington
-
West Chester, Pennsylvania, Forenede Stater, 19380
- Chester County Hospital
-
West Reading, Pennsylvania, Forenede Stater, 19611
- Reading Hospital
-
Wexford, Pennsylvania, Forenede Stater, 15090
- Wexford Health and Wellness Pavilion
-
Williamsport, Pennsylvania, Forenede Stater, 17754
- Divine Providence Hospital
-
Willow Grove, Pennsylvania, Forenede Stater, 19090
- Asplundh Cancer Pavilion
-
York, Pennsylvania, Forenede Stater, 17408
- UPMC Memorial
-
-
South Carolina
-
Anderson, South Carolina, Forenede Stater, 29621
- AnMed Health Cancer Center
-
Charleston, South Carolina, Forenede Stater, 29425
- Medical University of South Carolina
-
Gaffney, South Carolina, Forenede Stater, 29341
- Gibbs Cancer Center-Gaffney
-
Georgetown, South Carolina, Forenede Stater, 29440
- Tidelands Georgetown Memorial Hospital
-
Greenville, South Carolina, Forenede Stater, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Forenede Stater, 29615
- Prisma Health Cancer Institute - Eastside
-
Greer, South Carolina, Forenede Stater, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Forenede Stater, 29651
- Gibbs Cancer Center-Pelham
-
Murrells Inlet, South Carolina, Forenede Stater, 29576
- MUSC Health Tidelands Health Radiation Therapy Center
-
Rock Hill, South Carolina, Forenede Stater, 29732
- Levine Cancer Institute-Rock Hill
-
Rock Hill, South Carolina, Forenede Stater, 29730
- Rock Hill Radiation Therapy Center
-
Seneca, South Carolina, Forenede Stater, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Forenede Stater, 29303
- Spartanburg Medical Center
-
Union, South Carolina, Forenede Stater, 29379
- SMC Center for Hematology Oncology Union
-
West Columbia, South Carolina, Forenede Stater, 29169
- Lexington Medical Center
-
-
South Dakota
-
Aberdeen, South Dakota, Forenede Stater, 57401
- Avera Cancer Institute-Aberdeen
-
Mitchell, South Dakota, Forenede Stater, 57301
- Avera Cancer Institute - Mitchell
-
Pierre, South Dakota, Forenede Stater, 57501
- Avera Cancer Institute at Pierre
-
Sioux Falls, South Dakota, Forenede Stater, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Forenede Stater, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Forenede Stater, 57104
- Sanford Cancer Center Oncology Clinic
-
Yankton, South Dakota, Forenede Stater, 57078
- Avera Cancer Institute at Yankton
-
-
Tennessee
-
Collierville, Tennessee, Forenede Stater, 38017
- Baptist Memorial Hospital and Cancer Center-Collierville
-
Germantown, Tennessee, Forenede Stater, 38138
- The West Clinic - Wolf River
-
Memphis, Tennessee, Forenede Stater, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
Nashville, Tennessee, Forenede Stater, 37232
- Vanderbilt University/Ingram Cancer Center
-
Nashville, Tennessee, Forenede Stater, 37204
- Vanderbilt Breast Center at One Hundred Oaks
-
-
Texas
-
Amarillo, Texas, Forenede Stater, 79106
- The Don and Sybil Harrington Cancer Center
-
Conroe, Texas, Forenede Stater, 77384
- MD Anderson in The Woodlands
-
Dallas, Texas, Forenede Stater, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, Forenede Stater, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Dallas, Texas, Forenede Stater, 75237
- UT Southwestern Simmons Cancer Center - RedBird
-
Fort Worth, Texas, Forenede Stater, 76104
- UT Southwestern/Simmons Cancer Center-Fort Worth
-
Fort Worth, Texas, Forenede Stater, 76104
- Tarrant County Hospital District/JPS Health Network
-
Houston, Texas, Forenede Stater, 77030
- M D Anderson Cancer Center
-
Houston, Texas, Forenede Stater, 77026-1967
- Lyndon Baines Johnson General Hospital
-
Houston, Texas, Forenede Stater, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Houston, Texas, Forenede Stater, 77030
- Ben Taub General Hospital
-
Houston, Texas, Forenede Stater, 77079
- MD Anderson West Houston
-
League City, Texas, Forenede Stater, 77573
- MD Anderson League City
-
Richardson, Texas, Forenede Stater, 75080
- UT Southwestern Clinical Center at Richardson/Plano
-
Round Rock, Texas, Forenede Stater, 78665
- Scott and White Healthcare Round Rock
-
San Antonio, Texas, Forenede Stater, 78229
- University of Texas Health Science Center at San Antonio
-
Sugar Land, Texas, Forenede Stater, 77478
- MD Anderson in Sugar Land
-
Temple, Texas, Forenede Stater, 76508
- Scott and White Memorial Hospital
-
-
Utah
-
Farmington, Utah, Forenede Stater, 84025
- Farmington Health Center
-
Salt Lake City, Utah, Forenede Stater, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, Forenede Stater, 84106
- University of Utah Sugarhouse Health Center
-
-
Vermont
-
Berlin Corners, Vermont, Forenede Stater, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Forenede Stater, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Forenede Stater, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Charlottesville, Virginia, Forenede Stater, 22908
- University of Virginia Cancer Center
-
Fairfax, Virginia, Forenede Stater, 22031
- Inova Schar Cancer Institute
-
Fairfax, Virginia, Forenede Stater, 22033
- Inova Fair Oaks Hospital
-
Falls Church, Virginia, Forenede Stater, 22042
- Inova Fairfax Hospital
-
Leesburg, Virginia, Forenede Stater, 20176
- Inova Loudoun Hospital
-
Martinsville, Virginia, Forenede Stater, 24112
- Sovah Health Martinsville
-
Richmond, Virginia, Forenede Stater, 23235
- VCU Massey Cancer Center at Stony Point
-
Richmond, Virginia, Forenede Stater, 23229
- Virginia Cancer Institute
-
Richmond, Virginia, Forenede Stater, 23298
- VCU Massey Comprehensive Cancer Center
-
-
Washington
-
Aberdeen, Washington, Forenede Stater, 98520
- Providence Regional Cancer System-Aberdeen
-
Bellingham, Washington, Forenede Stater, 98225
- PeaceHealth Saint Joseph Medical Center
-
Centralia, Washington, Forenede Stater, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Forenede Stater, 98026
- Swedish Cancer Institute-Edmonds
-
Everett, Washington, Forenede Stater, 98201
- Providence Regional Cancer Partnership
-
Issaquah, Washington, Forenede Stater, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Forenede Stater, 99336
- Kadlec Clinic Hematology and Oncology
-
Kirkland, Washington, Forenede Stater, 98034
- FHCC at EvergreenHealth
-
Lacey, Washington, Forenede Stater, 98503
- Providence Regional Cancer System-Lacey
-
Longview, Washington, Forenede Stater, 98632
- PeaceHealth Saint John Medical Center
-
Mount Vernon, Washington, Forenede Stater, 98274
- Skagit Regional Health Cancer Care Center
-
Renton, Washington, Forenede Stater, 98055
- Valley Medical Center
-
Seattle, Washington, Forenede Stater, 98101
- Virginia Mason Medical Center
-
Seattle, Washington, Forenede Stater, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Forenede Stater, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Forenede Stater, 98195
- University of Washington Medical Center - Montlake
-
Seattle, Washington, Forenede Stater, 98109
- Fred Hutchinson Cancer Center
-
Sedro-Woolley, Washington, Forenede Stater, 98284
- PeaceHealth United General Medical Center
-
Silverdale, Washington, Forenede Stater, 98383
- Saint Michael Cancer Center
-
Vancouver, Washington, Forenede Stater, 98686
- Legacy Salmon Creek Hospital
-
Vancouver, Washington, Forenede Stater, 98664
- PeaceHealth Southwest Medical Center
-
Vancouver, Washington, Forenede Stater, 98684
- Legacy Cancer Institute Medical Oncology and Day Treatment
-
Walla Walla, Washington, Forenede Stater, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Forenede Stater, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
-
West Virginia
-
Bridgeport, West Virginia, Forenede Stater, 26330
- United Hospital Center
-
Morgantown, West Virginia, Forenede Stater, 26506
- West Virginia University Healthcare
-
Parkersburg, West Virginia, Forenede Stater, 26101
- Camden Clark Medical Center
-
-
Wisconsin
-
Antigo, Wisconsin, Forenede Stater, 54409
- Langlade Hospital and Cancer Center
-
Ashland, Wisconsin, Forenede Stater, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, Forenede Stater, 54806
- Northwest Wisconsin Cancer Center
-
Burlington, Wisconsin, Forenede Stater, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- Marshfield Medical Center-EC Cancer Center
-
Germantown, Wisconsin, Forenede Stater, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Forenede Stater, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Forenede Stater, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Forenede Stater, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Forenede Stater, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Hayward, Wisconsin, Forenede Stater, 54843
- Essentia Health-Hayward Clinic
-
Kenosha, Wisconsin, Forenede Stater, 53142
- Aurora Cancer Care-Kenosha South
-
Marinette, Wisconsin, Forenede Stater, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Medical Center-Marshfield
-
Medford, Wisconsin, Forenede Stater, 54451
- Aspirus Medford Hospital
-
Menomonee Falls, Wisconsin, Forenede Stater, 53051
- Froedtert Menomonee Falls Hospital
-
Milwaukee, Wisconsin, Forenede Stater, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Forenede Stater, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Forenede Stater, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Forenede Stater, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, Forenede Stater, 54548
- Marshfield Medical Center - Minocqua
-
Mukwonago, Wisconsin, Forenede Stater, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Forenede Stater, 54017
- Cancer Center of Western Wisconsin
-
Oak Creek, Wisconsin, Forenede Stater, 53154
- Drexel Town Square Health Center
-
Oconomowoc, Wisconsin, Forenede Stater, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oshkosh, Wisconsin, Forenede Stater, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Forenede Stater, 53406
- Aurora Cancer Care-Racine
-
Rhinelander, Wisconsin, Forenede Stater, 54501
- Aspirus Cancer Care - James Beck Cancer Center
-
Rice Lake, Wisconsin, Forenede Stater, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- Saint Vincent Hospital Cancer Center at Sheboygan
-
Spooner, Wisconsin, Forenede Stater, 54801
- Essentia Health-Spooner Clinic
-
Stevens Point, Wisconsin, Forenede Stater, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Stevens Point, Wisconsin, Forenede Stater, 54481
- Aspirus Cancer Care - Stevens Point
-
Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit, Wisconsin, Forenede Stater, 53066
- Aurora Medical Center in Summit
-
Superior, Wisconsin, Forenede Stater, 54880
- Essentia Health Saint Mary's Hospital - Superior
-
Two Rivers, Wisconsin, Forenede Stater, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Forenede Stater, 53188
- UW Cancer Center at ProHealth Care
-
Wausau, Wisconsin, Forenede Stater, 54401
- Aspirus Regional Cancer Center
-
Wauwatosa, Wisconsin, Forenede Stater, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, Forenede Stater, 53227
- Aurora West Allis Medical Center
-
West Bend, Wisconsin, Forenede Stater, 53095
- Froedtert West Bend Hospital/Kraemer Cancer Center
-
Weston, Wisconsin, Forenede Stater, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
-
Wyoming
-
Sheridan, Wyoming, Forenede Stater, 82801
- Welch Cancer Center
-
-
-
-
-
Bayamón, Puerto Rico, 00959-5060
- Cancer Center-Metro Medical Center Bayamon
-
Manatí, Puerto Rico, 00674
- Doctors Cancer Center
-
San Juan, Puerto Rico, 00917
- San Juan Community Oncology Group
-
San Juan, Puerto Rico, 00927
- Centro Comprensivo de Cancer de UPR
-
San Juan, Puerto Rico, 00936
- San Juan City Hospital
-
San Juan, Puerto Rico, 00902
- Pan American Center for Oncology Trials LLC
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år og ældre (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Beskrivelse
Inklusionskriterier:
- Stadium: Klinisk fase II eller III rektalt adenokarcinom defineret som T4N0 eller ethvert T med knudepositiv sygdom (enhver T, N+); også T3N0, der kræver abdominal perineal resektion (APR) eller coloanal anastomose
- Tumorsted: Rectum; =< 12 cm fra analkanten
- Ingen tidligere systemisk kemoterapi, målrettet terapi eller immunterapi; eller strålebehandling administreret som behandling for tyktarmskræft inden for de seneste 5 år er tilladt
Ikke gravid og ikke ammende, fordi denne undersøgelse involverer et middel, der har kendt genotoksiske, mutagene og teratogene virkninger
* Kun for kvinder i den fødedygtige alder kræves derfor en negativ graviditetstest (urin eller serum i henhold til institutionelle retningslinjer) udført =< 14 dage før registrering. Kvindelige forsøgspersoner er enige om at bruge højeffektiv prævention kombineret med en yderligere barrieremetode (f.eks. mellemgulv, med et sæddræbende middel), mens de er i undersøgelsen og i >= 9 måneder efter sidste dosis af undersøgelseslægemidlet, og de samme kriterier gælder for mandlige forsøgspersoner, hvis de har en partner med fødselspotentiale. Mandlig forsøgsperson indvilliger i at bruge kondom og ikke donere sæd i denne undersøgelse og i >= 6 måneder efter sidste behandling
- Alder >= 18 år
- Eastern Cooperative Oncology Group (ECOG) præstationsstatus =< 2 (eller Karnofsky >= 60 %)
- Absolut neutrofiltal (ANC) >= 1.500/mm^3
- Blodpladetal >= 100.000/mm
Kreatinin =< 1,5 x øvre normalgrænse (ULN) ELLER beregnet (beregnet) kreatininclearance >= 50 ml/min
^3
- Total bilirubin =< 1,5 x øvre normalgrænse (ULN)
- Aspartataminotransferase (AST)/alaninaminotransferase (ALT) =< 3 x øvre normalgrænse (ULN)
- Ingen øvre rektale tumorer (tumorens distale margin > 12 cm fra analkanten)
- Ingen tilbagevendende endetarmskræft; forudgående transanal excision, tidligere distal sigmoidcancer med lav anastomose
- Ingen kendt mismatch reparation mangelfuld rektal adenokarcinom
- Humant immundefektvirus HIV-inficerede patienter i effektiv anti-retroviral behandling med upåviselig viral belastning inden for 6 måneder er kvalificerede til dette forsøg
- Patienter med kendt historie eller aktuelle symptomer på hjertesygdom, eller historie med behandling med kardiotoksiske midler, bør have en klinisk risikovurdering af hjertefunktionen ved hjælp af New York Heart Association Functional Classification1. For at være berettiget til dette forsøg skal patienter være klasse 2B eller bedre
- Kronisk samtidig behandling med stærke hæmmere af CYP3A4 er ikke tilladt i denne undersøgelse. Patienter på stærke CYP3A4-hæmmere skal seponere lægemidlet i 14 dage før registrering i undersøgelsen * Kronisk samtidig behandling med stærke CYP3A4-inducere er ikke tilladt. Patienter skal seponere lægemidlet 14 dage før starten af undersøgelsesbehandlingen
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Sekventiel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Aktiv komparator: Gruppe I (LCRT, FOLFOX eller CAPOX)
Patienter modtager lang-forløb kemoradiationsterapi på studiet og modtager derefter enten: FOLFOX-regimen bestående af leucovorin IV, fluorouracil IV og oxaliplatin IV eller CAPOX bestående af capecitabin PO og oxaliplatin IV på undersøgelsen.
Patienterne gennemgår CT-scanning, MR-scanning og indsamling af bioprøver under hele forsøget.
Patienter gennemgår også sigmoidoskopi under hele forsøget og biopsi under screening.
|
Givet IV
Givet PO
Givet IV
Givet IV
Modtag LCRT
gennemgå CT
gennemgå MR
gennemgå sigmoidoskopi
gennemgå biopsi
|
|
Eksperimentel: Gruppe II (LCRT, FOLFIRINOX)
Patienterne modtager langtidsbehandling med kemoradiation i undersøgelsen og får derefter FOLFIRINOX-regimen bestående af leucovorin IV, fluorouracil IV, irinotecan IV og oxaliplatin IV i undersøgelsen.
Patienterne gennemgår CT-scanning, MR-scanning og blodprøvetagning under hele forsøget.
Patienter gennemgår sigmoidoskopi under hele forsøget og biopsi under screening.
|
Givet IV
Givet IV
Givet PO
Givet IV
Givet IV
Modtag LCRT
gennemgå CT
gennemgå MR
gennemgå sigmoidoskopi
gennemgå biopsi
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Clincal Complete Response (cCR) rater
Tidsramme: Op til 5 år
|
efineret som antallet af patienter, der opnåede cCR ved slutningen af total neoadjuverende terapi (TNT) divideret med antallet af patienter inkluderet i analysepopulationen. Dette endepunkt vil blive vurderet inden for 8-12 uger efter afslutning af TNT. Hvis der er en cCR, vil patienten blive talt i tælleren. Hvis der er et næsten fuldstændigt svar (nCR), vil der blive foretaget en re-evaluering inden for 4-8 uger. Hvis tumoren har udviklet sig til en cCR, vil patienten blive talt i tælleren. Ellers vil patienten blive anset for IKKE at have opnået cCR-status. divideret med antallet af patienter inkluderet i analysepopulationen. |
Op til 5 år
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Sygdomsfri overlevelse (DFS) rate
Tidsramme: rom dato for randomisering, vurderet op til 5 år
|
Defineret som tiden fra datoen for randomisering til datoen for første forekomst af følgende hændelser: død på grund af alle årsager, tumor, der gentager sig lokalt efter en R0 total mesorektal excision (TME), tumor, der vokser tilbage efter en indledende tilsyneladende klinisk og radiologisk CR og kan ikke fjernes kirurgisk med en R0 TME og M1 sygdom diagnosticeret på noget tidspunkt efter påbegyndelse af behandlingen.
|
rom dato for randomisering, vurderet op til 5 år
|
|
Organ-bevarelsestid (OPT)
Tidsramme: Fra dato for randomisering, vurderet op til 5 år
|
Defineret som tiden fra datoen for randomisering til datoen for den første forekomst af følgende hændelser: TME udført eller forsøgt, tumor, der vokser tilbage efter en indledende tilsyneladende klinisk og radiologisk fuldstændig respons (CR) og død på grund af alle årsager.
|
Fra dato for randomisering, vurderet op til 5 år
|
|
Tid til fjernmetastase (TDM)
Tidsramme: Fra datoen for randomisering til datoen for første dokumenterede fjernmetastase, vurderet op til 5 år
|
Vil blive estimeret i hver arm ved hjælp af metoden fra Kaplan-Meier og sammenlignet med en stratificeret Cox-regressionsmodel.
|
Fra datoen for randomisering til datoen for første dokumenterede fjernmetastase, vurderet op til 5 år
|
|
Samlet overlevelse (OS)
Tidsramme: Fra datoen for randomisering til datoen for dødsfald på grund af alle årsager, vurderet op til 5 år
|
Vil blive estimeret i hver arm ved hjælp af metoden fra Kaplan-Meier og sammenlignet med en stratificeret Cox-regressionsmodel.
|
Fra datoen for randomisering til datoen for dødsfald på grund af alle årsager, vurderet op til 5 år
|
|
Forekomst af bivirkninger (AE'er)
Tidsramme: Op til 5 år
|
Defineret som andelen af patienter, der oplevede mindst én grad 3, grad 4 eller grad 5 af hver type AE.
De overordnede uønskede hændelser for grad 3 eller højere hændelser vil blive sammenlignet mellem to behandlingsgrupper ved hjælp af Chi-square test (eller Fishers eksakte test, hvis dataene i beredskabstabellen er sparsomme).
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Op til 5 år
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Samarbejdspartnere
Efterforskere
- Studiestol: J. Joshua Smith, MD, Memorial Sloan Kettering Cancer Center
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Scott AJ, Kennedy EB, Berlin J, Brown G, Chalabi M, Cho MT, Cusnir M, Dorth J, George M, Kachnic LA, Kennecke HF, Loree JM, Morris VK, Perez RO, Smith JJ, Strickland MR, Gholami S. Management of Locally Advanced Rectal Cancer: ASCO Guideline. J Clin Oncol. 2024 Oct;42(28):3355-3375. doi: 10.1200/JCO.24.01160. Epub 2024 Aug 8.
- Alvarez JA, Shi Q, Dasari A, Garcia-Aguilar J, Sanoff H, George TJ, Hong T, Yothers G, Philip P, Nelson G, Al Baghdadi T, Alese OB, Zambare W, Omer D, Verheij FS, Bercz A, Kim MJ, Buckley J, Williams H, George M, Garcia R, Gallagher P, O'Reilly EM, Meyerhardt JA, Crawley J, Shergill A, Horvat N, Romesser PB, Hall W, Smith JJ. Alliance A022104/NRG-GI010: The Janus Rectal Cancer Trial: a randomized phase II/III trial testing the efficacy of triplet versus doublet chemotherapy regarding clinical complete response and disease-free survival in patients with locally advanced rectal cancer. BMC Cancer. 2024 Jul 26;24(1):901. doi: 10.1186/s12885-024-12529-7.
- Alvarez J, Shi Q, Dasari A, Garcia-Aguilar J, Sanoff H, George TJ, Hong TS, Yothers G, Philip PA, Nelson GD, Al Baghdadi T, Alese O, Zambare W, Omer DM, Verheij FS, Buckley J, Williams H, George M, Garcia R, O'Reilly EM, Meyerhardt JA, Shergill A, Horvat N, Romesser PB, Hall WA, Smith JJ. ALLIANCE A022104/NRG-GI010: The Janus Rectal Cancer Trial: a randomized phase II/III trial testing the efficacy of triplet versus doublet chemotherapy regarding clinical complete response and disease-free survival in patients with locally advanced rectal cancer. medRxiv [Preprint]. 2024 Apr 27:2024.04.25.24306396. doi: 10.1101/2024.04.25.24306396.
- Langenfeld SJ, Davis BR, Vogel JD, Davids JS, Temple LKF, Cologne KG, Hendren S, Hunt S, Garcia Aguilar J, Feingold DL, Lightner AL, Paquette IM; Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Rectal Cancer 2023 Supplement. Dis Colon Rectum. 2024 Jan 1;67(1):18-31. doi: 10.1097/DCR.0000000000003057. Epub 2023 Aug 20. No abstract available.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
8. december 2022
Primær færdiggørelse (Anslået)
30. september 2026
Studieafslutning (Anslået)
30. september 2033
Datoer for studieregistrering
Først indsendt
1. november 2022
Først indsendt, der opfyldte QC-kriterier
2. november 2022
Først opslået (Faktiske)
9. november 2022
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Anslået)
8. september 2025
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
5. september 2025
Sidst verificeret
1. september 2025
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Neoplasmer efter sted
- Neoplasmer
- Tarmsygdomme
- Gastrointestinale neoplasmer
- Neoplasmer i fordøjelsessystemet
- Sygdomme i fordøjelsessystemet
- Gastrointestinale sygdomme
- Kolorektale neoplasmer
- Intestinale neoplasmer
- Endetarmssygdomme
- Rektale neoplasmer
- Organiske kemikalier
- Heterocykliske forbindelser, 1-ring
- Heterocykliske forbindelser
- Heterocykliske forbindelser, 2-ring
- Heterocykliske forbindelser, smeltet ring
- Undersøgelsesteknikker
- Håndtering af eksemplar
- Kliniske laboratorieteknikker
- Diagnostiske teknikker og procedurer
- Diagnose
- Kirurgiske procedurer, operative
- Minimalt invasive kirurgiske procedurer
- Cytologiske teknikker
- Nukleinsyrer, nukleotider og nukleosider
- Cytodiagnose
- Camptothecin
- Alkaloider
- Koordinationskomplekser
- Deoxycytidin
- Cytidin
- Pyrimidin -nukleosider
- Pyrimidiner
- Diagnostiske teknikker, kirurgisk
- Endoskopi, gastrointestinal
- Endoskopi, fordøjelsessystem
- Diagnostiske teknikker, fordøjelsessystem
- Endoskopi
- Kirurgiske procedurer for fordøjelsessystem
- Kemiteknikker, analytisk
- Spektrumanalyse
- Nukleosider
- Leucovorin
- Formyltetrahydrofolater
- Tetrahydrofolater
- Folinsyre
- Pterins
- Pteridiner
- Uracil
- Pyrimidinoner
- Deoxyribonucleosider
- Kolonoskopi
- Capecitabin
- Oxaliplatin
- Irinotecan
- Fluorouracil
- Levoleucovorin
- Biopsi
- Magnetisk resonansspektroskopi
- Sigmoidoskopi
Andre undersøgelses-id-numre
- A022104
- U10CA180821 (U.S. NIH-bevilling/kontrakt)
- NCI-2022-07800 (Anden identifikator: NCI)
- NRG-GI010 (Anden identifikator: NRG Oncology)
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
JA
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Ingen
Studerer et amerikansk FDA-reguleret enhedsprodukt
Ingen
produkt fremstillet i og eksporteret fra U.S.A.
Ingen
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
Kliniske forsøg med Oxaliplatin
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Xijing HospitalUkendt
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Lin ChenUkendtGastrisk AdenocarcinomKina
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University of California, DavisNational Cancer Institute (NCI)AfsluttetStadie IV brystkræftForenede Stater
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Gynecologic Oncology GroupNational Cancer Institute (NCI)AfsluttetLivmoderhalskræft | Primær peritoneal kræftForenede Stater, Canada
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Gynecologic Oncology GroupNational Cancer Institute (NCI)AfsluttetLivmoderhalskræftForenede Stater, Canada
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Ohio State University Comprehensive Cancer CenterNational Cancer Institute (NCI)AfsluttetHoved- og halskræftForenede Stater
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St. Jude Children's Research HospitalNational Cancer Institute (NCI)AfsluttetUspecificeret fast tumor i barndommen, protokolspecifikForenede Stater
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Jenny DrottAfsluttetKolorektale neoplasmerSverige
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SanofiAfsluttet
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Gustave Roussy, Cancer Campus, Grand ParisNational Cancer Institute, FranceAfsluttet