- ICH GCP
- Yhdysvaltain kliinisten tutkimusten rekisteri
- Kliininen tutkimus NCT00034554
Study of gp75 Vaccine in Patients With Stage III and IV Melanoma
torstai 8. huhtikuuta 2010 päivittänyt: Eli Lilly and Company
Phase I Study of gp75 DNA Vaccine in Patients With AJCC Stage III and IV Melanoma
Up to 24 patients with stage III or stage IV melanoma will be enrolled.
Patients who are currently disease-free but at high risk for relapse are also eligible.
Patients will receive vaccinations of gp75 at assigned dose levels.
Patients who exhibit serologic and stable/clinical response are eligible to receive booster vaccinations.
Patients will be evaluated for safety and efficacy throughout the duration of the study.
In this study, the optimal biologically effective dose is defined as the lowest dose of gp75 that results in the production of anti-gp75 antibodies.
Tutkimuksen yleiskatsaus
Yksityiskohtainen kuvaus
This study is designed to evaluate the safety and feasibility of intramuscular vaccination with gp75 DNA in patients with stage III or IV melanoma.
Secondary objectives are to observe the patient for any evidence of anti-tumor response and to establish the optimal biologically effective dose.
Up to 24 evaluable patients with stage III or IV metastatic melanoma or with stage III melanoma, currently disease-free, but at high risk for recurrence will be enrolled.
Patients will be be enrolled into an assigned dose group and will receive five vaccinations of gp75.
In order for dose escalation to proceed, only one patient in the current dose group may have demonstrated a dose limiting toxicity (DLT).
If a second patient experiences such toxicity then both patients will move down to the previous dose level, and the previous dose level will be considered to be the MTD.
If no DLTs are encountered, patients will continue on study at the assigned dose level.
Any patient experiencing a DLT will not receive further vaccination until the toxicity has resolved.
Patients exhibiting both serological and stable/clinical response after receiving the fifth vaccination will be eligible to receive booster vaccinations.
An additional patient will be accrued to the dose level for every patient that progresses prior to the fifth vaccination.
Opintotyyppi
Interventio
Ilmoittautuminen (Todellinen)
31
Vaihe
- Vaihe 1
Yhteystiedot ja paikat
Tässä osiossa on tutkimuksen suorittajien yhteystiedot ja tiedot siitä, missä tämä tutkimus suoritetaan.
Opiskelupaikat
-
-
New York
-
New York, New York, Yhdysvallat, 10021
- ImClone Investigational Site
-
-
Osallistumiskriteerit
Tutkijat etsivät ihmisiä, jotka sopivat tiettyyn kuvaukseen, jota kutsutaan kelpoisuuskriteereiksi. Joitakin esimerkkejä näistä kriteereistä ovat henkilön yleinen terveydentila tai aiemmat hoidot.
Kelpoisuusvaatimukset
Opintokelpoiset iät
18 vuotta ja vanhemmat (Aikuinen, Vanhempi Aikuinen)
Hyväksyy terveitä vapaaehtoisia
Ei
Sukupuolet, jotka voivat opiskella
Kaikki
Kuvaus
Inclusion Criteria:
- The patient has a diagnosis of American Joint Commission on Cancer (AJCC) stage 111 or IV malignant melanoma. A patient who is free of disease after surgical resection of stage 111 or IV disease, but at high risk (defined as a primary tumor >4 rnm, satellite or in-transit lesions, one or more positive lymph nodes or distant metastases) for recurrence is also eligible. A patient with metastatic disease may have no more than five sites of disease. The skin represents one site regardless of the number of lesions. Stage 111 melanoma is defined as a pT4 primary tumor (>4m in depth or Clark level 5) in-transit metastases, satellites lesions or regional lymph nodes involved with melanoma.Pathology slides must be reviewed by the investigational site's Department of Pathology.
- The patient's Karnofsky performance status is 280 at study entry.
- The patient has given signed informed consent.
- The patient has had surgery for their melanoma at least 6 months prior to study entry, or has had prior interferon therapy, or developed unacceptable toxicities to interferon therapy, or has a pre-existing condition(s) that precludes the patient fkom receiving interferon treatment.
- The patient is 21 8 years of age.
- The patient must have completed any prior irradiation, chemotherapy, or systemic immunotherapy (interferon-alpha, or interleukin-2) at least 30 days prior to study entry.
- The patient has adequate hematologic function as defined as a platelet count 2100,000/mm3 and white blood cell (WBC) level 23,000/mm3.
- The patient has serum lactose dehydrogenase (LDH) within normal range and a serum creatinine level <2.0 mg/dL.
- The patient agrees to use effective contraception if procreative potential exists.
Exclusion Criteria:
- The patient has stage I11 disease otherwise eligible to receive standard of care melanoma therapy.
- The patient has a medical condition or use of medication (eg, corticosteroids) that might make it difficult for the patient to complete the full course of treatments or to respond immunologically to them, in the opinion of the investigator.
- The patient has received irradiation, chemotherapy, or systemic immunotherapy (interferon-alpha, or interleukin-2) within 30 days prior to study entry.
- The patient is pregnant (confirmed by serum beta human chorionic gonadotropin [PHCG], if applicable) or is breast feeding.
- The patient has received any investigational agents within 30 days of study entry.
- The patient has received prior cancer vaccine therapy.
- The patient has evidence of central nervous system (CNS) metastasis.
- The patient has evidence of an ocular abnormality, as detected by a slit-lamp ophthalmologic examination, within 4 weeks prior to study entry.
Opintosuunnitelma
Tässä osiossa on tietoja tutkimussuunnitelmasta, mukaan lukien kuinka tutkimus on suunniteltu ja mitä tutkimuksella mitataan.
Miten tutkimus on suunniteltu?
Suunnittelun yksityiskohdat
- Ensisijainen käyttötarkoitus: Hoito
- Jako: Ei satunnaistettu
- Inventiomalli: Yksittäinen ryhmätehtävä
- Naamiointi: Ei mitään (avoin tarra)
Aseet ja interventiot
Osallistujaryhmä / Arm |
Interventio / Hoito |
|---|---|
|
Kokeellinen: 1
0.1mg
|
6 patients will be enrolled in each of the 5 vaccination groups.
Patients in vaccination groups 1-3 will receive a total of 5(1 mL) vaccinations.
Patients assigned to vaccination group 4 will receive a total of 5 (2.0 mL) vaccinations administered as 2 1 mL injections.
Patients assigned to vaccination group 5 will receive a total of 5 (4.0 mL or 8.0 mg)vaccinations administered as 4 1 mL injections per vaccination treatment Patients will receive gp75 DNA vaccinations every 3 weeks for 5 vaccinations.
Injection sites will be given intramuscularly and rotated for each dose using all 4 limbs with the exception of a site that had the removal of lymph nodes.
Progression to next higher dose level will be based on the 5* patient safely completing the 2nd vaccination at the lower dose level.
|
|
Kokeellinen: 2
0.5mg
|
6 patients will be enrolled in each of the 5 vaccination groups.
Patients in vaccination groups 1-3 will receive a total of 5(1 mL) vaccinations.
Patients assigned to vaccination group 4 will receive a total of 5 (2.0 mL) vaccinations administered as 2 1 mL injections.
Patients assigned to vaccination group 5 will receive a total of 5 (4.0 mL or 8.0 mg)vaccinations administered as 4 1 mL injections per vaccination treatment Patients will receive gp75 DNA vaccinations every 3 weeks for 5 vaccinations.
Injection sites will be given intramuscularly and rotated for each dose using all 4 limbs with the exception of a site that had the removal of lymph nodes.
Progression to next higher dose level will be based on the 5* patient safely completing the 2nd vaccination at the lower dose level.
|
|
Kokeellinen: 3
2.0mg
|
6 patients will be enrolled in each of the 5 vaccination groups.
Patients in vaccination groups 1-3 will receive a total of 5(1 mL) vaccinations.
Patients assigned to vaccination group 4 will receive a total of 5 (2.0 mL) vaccinations administered as 2 1 mL injections.
Patients assigned to vaccination group 5 will receive a total of 5 (4.0 mL or 8.0 mg)vaccinations administered as 4 1 mL injections per vaccination treatment Patients will receive gp75 DNA vaccinations every 3 weeks for 5 vaccinations.
Injection sites will be given intramuscularly and rotated for each dose using all 4 limbs with the exception of a site that had the removal of lymph nodes.
Progression to next higher dose level will be based on the 5* patient safely completing the 2nd vaccination at the lower dose level.
|
|
Kokeellinen: 4
4.0mg
|
6 patients will be enrolled in each of the 5 vaccination groups.
Patients in vaccination groups 1-3 will receive a total of 5(1 mL) vaccinations.
Patients assigned to vaccination group 4 will receive a total of 5 (2.0 mL) vaccinations administered as 2 1 mL injections.
Patients assigned to vaccination group 5 will receive a total of 5 (4.0 mL or 8.0 mg)vaccinations administered as 4 1 mL injections per vaccination treatment Patients will receive gp75 DNA vaccinations every 3 weeks for 5 vaccinations.
Injection sites will be given intramuscularly and rotated for each dose using all 4 limbs with the exception of a site that had the removal of lymph nodes.
Progression to next higher dose level will be based on the 5* patient safely completing the 2nd vaccination at the lower dose level.
|
|
Kokeellinen: 5
8.0mg
|
6 patients will be enrolled in each of the 5 vaccination groups.
Patients in vaccination groups 1-3 will receive a total of 5(1 mL) vaccinations.
Patients assigned to vaccination group 4 will receive a total of 5 (2.0 mL) vaccinations administered as 2 1 mL injections.
Patients assigned to vaccination group 5 will receive a total of 5 (4.0 mL or 8.0 mg)vaccinations administered as 4 1 mL injections per vaccination treatment Patients will receive gp75 DNA vaccinations every 3 weeks for 5 vaccinations.
Injection sites will be given intramuscularly and rotated for each dose using all 4 limbs with the exception of a site that had the removal of lymph nodes.
Progression to next higher dose level will be based on the 5* patient safely completing the 2nd vaccination at the lower dose level.
|
Mitä tutkimuksessa mitataan?
Ensisijaiset tulostoimenpiteet
Tulosmittaus |
|---|
|
Evaluate the safety and feasibility of intramuscular vaccination with gp75 DNA in patients with stage III or IV melanoma.
|
Toissijaiset tulostoimenpiteet
Tulosmittaus |
|---|
|
Observe patients for any evidence of anti-tumor response, which is generated after vaccination.
|
|
Establish the optimal biologically effective dose, defined as the lowest dose that correlates the production of anti-gp75 antibodies.
|
Yhteistyökumppanit ja tutkijat
Täältä löydät tähän tutkimukseen osallistuvat ihmiset ja organisaatiot.
Sponsori
Yhteistyökumppanit
Julkaisuja ja hyödyllisiä linkkejä
Tutkimusta koskevien tietojen syöttämisestä vastaava henkilö toimittaa nämä julkaisut vapaaehtoisesti. Nämä voivat koskea mitä tahansa tutkimukseen liittyvää.
Yleiset julkaisut
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- Vijayasaradhi S, Doskoch PM, Wolchok J, Houghton AN. Melanocyte differentiation marker gp75, the brown locus protein, can be regulated independently of tyrosinase and pigmentation. J Invest Dermatol. 1995 Jul;105(1):113-9. doi: 10.1111/1523-1747.ep12313414.
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Opintojen ennätyspäivät
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Tähän tutkimukseen liittyvät termit
Muita asiaankuuluvia MeSH-ehtoja
Muut tutkimustunnusnumerot
- CP09-0001
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