Telerehabilitation Cognitive Impairments Following Chemotherapy Usability Study (TCIFCU)

At NJ Bioscience Center Healthy Volunteers

• Female
• Age 20 to 65;
• Good or corrected hearing;
• Good or corrected vision;
• No motor or cognitive impairments;
• English speakers;
• Those with low propensity for simulation sickness (as determined by the Simulation Sickness Questionnaire [Kennedy et al, 1993]).
• Either healthy or having had stage II or stage III breast cancer;
• Montreal Cognitive Assessment (MoCA) Score 10-25 indicating mild to moderate impairment [Chapman 2016] or 26-30 indicating normal cognition;

EXCLUSION CRITERIA

• Male;
• Female participants younger than 20 or older than 65;
• High propensity for simulation sickness (as determined by Simulation Sickness Questionnaire screening);
• Those with severe visual neglect or legally blind;
• Those with severe hearing loss or deafness;
• Those with uncontrolled hypertension (>190/100 mmHg);
• Those with severe cognitive impairment (MoCA score<10);
• Current diagnosis of moderate-severe depression (Beck Depression Inventory II score of 17-63);
• a history of psychiatric illness, defined as serious psychiatric illness such as bipolar mood disorder and schizophrenia, or requiring psychiatric hospitalization.
• a history of or current substance abuse;
• a previous head injury resulting in loss of consciousness;
• a prior diagnosis of neurological illness;
• a current or prior diagnosis of brain cancer;
• non-English speakers;
• Those unable to reliable participate in pre-study assessment due to any reason;
• Those with co-morbidities limiting arm and neck motor function (ex. lymphedema, chronic pain, severe arthritis);
• Less than 1 month post first chemotherapy regimen or starting chemotherapy during 16 weeks post screening (as chemotherapy during study participation is a confounding factor);
• Those with Stage IV (metastatic) breast cancer will be excluded;
• Those presenting with multiple cancers, such as breast and arm bone cancer, or breast and brain cancer;
• Those who are unwilling to allow a home inspection to ascertain Internet quality, determine best placement for the experimental or sham systems, for installation and removal of the systems and necessary repairs.