Tämä sivu käännettiin automaattisesti, eikä käännösten tarkkuutta voida taata. Katso englanninkielinen versio lähdetekstiä varten.

The SAVOR Study: Appetite and Physiological Responses (SAVOR)

keskiviikko 3. kesäkuuta 2026 päivittänyt: Darel Toh, Singapore Institute of Food and Biotechnology Innovation

Seniors' Appetite: Vibrant Opportunities for Revitalization (SAVOR)

The study aims to identify key physiological factors that differentiate older adults with healthy appetites from those experiencing appetite decline. The investigators hypothesize that seniors experiencing appetite decline will exhibit distinct oro-sensory, gastrointestinal, and hormonal profiles compared to seniors with healthy appetites, suggesting underlying biological mechanisms contributing to reduced appetite.

Tutkimuksen yleiskatsaus

Tila

Ei vielä rekrytointia

Ehdot

Interventio / Hoito

Yksityiskohtainen kuvaus

Appetite decline in older adults, or anorexia of aging, is a prevalent geriatric syndrome associated with decreased quality of life, increased risk of malnutrition, and accelerated decline in health. While current nutritional guidelines often emphasize increasing nutrient density, these strategies often fail to address the root causes of diminished appetite. Emerging research highlights the critical role of age-related physiological changes, particularly dysregulation of the gut-brain axis, altered sensory perception, and hormonal imbalances, in suppressing appetite. Notably, existing evidence is largely derived from Western populations, which may not fully reflect the influence of cultural and lifestyle factors on appetite in Asian seniors. This leaves a significant gap in understanding and addressing appetite loss within this specific demographic. This study aims to address this gap by comprehensively investigating the physiological mechanisms underlying appetite regulation in Asian seniors, to identify key determinants that differentiate individuals with healthy appetites from those experiencing a decline. By assessing the relationships between oro-sensory function, gastric dynamics, neuro-hormonal regulation, gut microbiome composition and subjective appetite, this study seeks to provide a deeper understanding of the biological pathways driving appetite differences in this population. The findings of this study will lay the groundwork for future research aimed at developing culturally sensitive and effective interventions that can restore appetite, improve nutritional status, and ultimately enhance the health span and quality of life for older adults in Singapore and beyond. Furthermore, this work has the potential to drive innovation in the food and nutrition industry, leading to the development of tailored products and dietary strategies that effectively address the unique nutritional needs of aging populations, ultimately impacting public health recommendations and policies related to senior nutrition.

Opintotyyppi

Interventio

Ilmoittautuminen (Arvioitu)

20

Vaihe

  • Ei sovellettavissa

Yhteystiedot ja paikat

Tässä osiossa on tutkimuksen suorittajien yhteystiedot ja tiedot siitä, missä tämä tutkimus suoritetaan.

Opiskeluyhteys

Tutki yhteystietojen varmuuskopiointi

Opiskelupaikat

Osallistumiskriteerit

Tutkijat etsivät ihmisiä, jotka sopivat tiettyyn kuvaukseen, jota kutsutaan kelpoisuuskriteereiksi. Joitakin esimerkkejä näistä kriteereistä ovat henkilön yleinen terveydentila tai aiemmat hoidot.

Kelpoisuusvaatimukset

Opintokelpoiset iät

  • Vanhempi Aikuinen

Hyväksyy terveitä vapaaehtoisia

Joo

Kuvaus

Inclusion Criteria:

  • Postmenopausal female
  • Aged 65-74 years
  • Habitual breakfast consumer (consumes breakfast between 7am to 10am)
  • Willingness to consume meals and follow intervention protocol
  • English speaking

Exclusion Criteria:

  • BMI ≥ 27.5
  • Diagnosed with medical condition that may influence appetite or microbiome (e.g. diabetes, thyroid disorders, gastrointestinal diseases)
  • Currently taking any medications or supplements that may influence appetite or the microbiome (e.g. probiotics, antibiotics, appetite stimulants/suppressants) one month prior to their first visit in consultation with study physician, PI and study team
  • Following a special diet for weight management (e.g. low-calorie, low carbohydrate)
  • History of bariatrics surgery
  • Intentional attempt to change body weight or composition
  • History of severe vasovagal syncope (blackouts or near faints) following blood draw
  • Drug abuse within last 5 years
  • Excessive alcoholic beverage consumption > 2 servings per day (1 serving defined as 360 mL beer, 150 mL wine or 45 mL distilled spirits)
  • Smoking (cigarette, e-cigarette, cigar, pipe, vape)
  • Engaging in habitual vigorous physical activity (as defined by physical activity questionnaire-PAQ)
  • Loose teeth or jaw pain
  • Not missing > 2 non-wisdom molars
  • Involvement in other clinical studies that may influence the outcome of the study
  • A study team member or their immediate family member

Opintosuunnitelma

Tässä osiossa on tietoja tutkimussuunnitelmasta, mukaan lukien kuinka tutkimus on suunniteltu ja mitä tutkimuksella mitataan.

Miten tutkimus on suunniteltu?

Suunnittelun yksityiskohdat

  • Ensisijainen käyttötarkoitus: Muut
  • Jako: Ei käytössä
  • Inventiomalli: Yksittäinen ryhmätehtävä
  • Naamiointi: Ei mitään (avoin tarra)

Aseet ja interventiot

Osallistujaryhmä / Arm
Interventio / Hoito
Kokeellinen: Chicken porridge
Rice congee with shredded chicken and vegetable oil
Muut: Shredded Chicken Congee
This is a mixed meal tolerance test intended to elicit gut hormone responses reflective of real-world dietary patterns.

Mitä tutkimuksessa mitataan?

Ensisijaiset tulostoimenpiteet

Tulosmittaus
Toimenpiteen kuvaus
Aikaikkuna
Ad Libitum Lunch
Aikaikkuna: Participants will be given 30 minutes to consume the meal until they are comfortably full, 180 minutes after the start of the intervention.
Participants will be asked to eat as much of the stir-fried beehoon as they want until they are comfortably full, to measure the exact calorie intake by weighing the food before and after eating.
Participants will be given 30 minutes to consume the meal until they are comfortably full, 180 minutes after the start of the intervention.

Toissijaiset tulostoimenpiteet

Tulosmittaus
Toimenpiteen kuvaus
Aikaikkuna
Palatability questionnaire
Aikaikkuna: Administered after consuming test meal and after consuming the ad libitum meal.
Palatability appetite questionnaire, rated on a visual analogue scale is a psychometric assessment tool where participants rate their subjective sensory experience-such as taste, smell, or pleasantness-by marking a point along a continuous 100 mm line anchored by opposing extremes (e.g., "extremely unpleasant" to "extremely pleasant").
Administered after consuming test meal and after consuming the ad libitum meal.
Appetite hormones
Aikaikkuna: Blood samples will be collected at timepoints (t = -15 minute (baseline), 30, 60, 90, 120 and 180 minutes)
GLP-1, PYY and Acyl-ghrelin will be used to measure hormones related to appetite.
Blood samples will be collected at timepoints (t = -15 minute (baseline), 30, 60, 90, 120 and 180 minutes)
Subjective Appetite Questionnaire
Aikaikkuna: Measurement is taken at t = -15 minute (baseline), 10, 30, 60, 90, 120 and 180 minutes
A subjective appetite questionnaire utilizes a Visual Analogue Scale to quantify a person's current metabolic state by measuring four key sensations: hunger, fullness, desire to eat, and prospective food consumption.
Measurement is taken at t = -15 minute (baseline), 10, 30, 60, 90, 120 and 180 minutes
Gastric Ultrasound
Aikaikkuna: Measurements will be taken at t = -15 minute (baseline), 15, 45, 105 and 165 minutes
Gastric ultrasound will measure the gastric emptying rate postprandially.
Measurements will be taken at t = -15 minute (baseline), 15, 45, 105 and 165 minutes
Stool collected using the OMNIgene and OMNImet
Aikaikkuna: Baseline stool sample will be collected once between screening and intervention day.
Stool sample will be collected in the OMNIgene-GUT and OMNImet-GUT tube for measurements that may include microbiome profiling, untargeted and targeted metabolome (e.g. bile acids and short-chain fatty acids profiling).
Baseline stool sample will be collected once between screening and intervention day.
Olfactory Acuity (SCENTinel)
Aikaikkuna: Baseline measurement administered once during screening, takes approximately 5-10 minutes
Olfactory acuity will be assessed using a simple, non-invasive SCENTinel rapid smell test. Participants will be presented with test cards containing various odors, and will be asked to detect, rate, and identify the odors. The test assesses the participant's ability to perceive and recognize smells, providing information on their overall sense of smell.
Baseline measurement administered once during screening, takes approximately 5-10 minutes
Taste Acuity Test (WETT)
Aikaikkuna: Baseline measurement administered once during screening, takes approximately 10-15 minutes
The Waterless Empirical Taste Test (WETT) is a sensory method for assessing how well participants can recognise and detect basic tastes. Participants will taste pre-moistened, paper-based test strips for the five basic tastes: sweet, sour, salty, bitter, and umami.
Baseline measurement administered once during screening, takes approximately 10-15 minutes
Blood plasma (Cytokines)
Aikaikkuna: t = -15 minute (baseline), 30, 60, 90, 120, 180 minutes
Blood samples may also be analyzed for indicators of inflammation including cytokines testing
t = -15 minute (baseline), 30, 60, 90, 120, 180 minutes
Blood plasma (Bile acids and short-chain fatty acids profiling)
Aikaikkuna: t= -15 minute (baseline), 30, 60, 90, 120, 180 minutes
Blood samples collected may be used to analyse biomarkers related to nutrition and digestive health e.g. bile acid and short-chain fatty acids profiling
t= -15 minute (baseline), 30, 60, 90, 120, 180 minutes
Bite Strength
Aikaikkuna: Baseline measurement that may be administered once during screening or test session, as schedule and equipment permits. Takes only a few minutes.
Bite strength will be measured using a bite force device (non-invasive) that records the maximum force a participant can exert while biting. Multiple measurements will be taken with rest periods in between to prevent fatigue.
Baseline measurement that may be administered once during screening or test session, as schedule and equipment permits. Takes only a few minutes.
Tongue Strength (Tongue Pressure)
Aikaikkuna: Baseline measurement that may be administered once during screening or test session, as schedule and equipment permits. Takes approximately 5 minutes.
Tongue pressure will be measured using a device equipped with a disposable air-filled bulb placed between the tongue and the hard palate. Participants will be instructed to press the bulb with their tongue as firmly as possible for a few seconds. Multiple measurements will be taken with rest periods in between to ensure accuracy and prevent fatigue.
Baseline measurement that may be administered once during screening or test session, as schedule and equipment permits. Takes approximately 5 minutes.

Muut tulostoimenpiteet

Tulosmittaus
Toimenpiteen kuvaus
Aikaikkuna
Health and Lifestyle questionnaire
Aikaikkuna: Baseline measurement that is completed during screening visit
This questionnaire is to evaluate the participant's eligibility for the study. It consist of participant information, medical and health history, lifestyle and diet, physical activity.
Baseline measurement that is completed during screening visit
3-day food record
Aikaikkuna: Administered between screening and actual test session, to be completed on 2 weekdays and 1 weekend.
A 3-day food record is a detailed diary where participants document everything they eat and drink over two weekdays and one weekend day to provide an accurate snapshot of their typical nutritional intake. This is done using household measures (or digital scales), where exact portion sizes, cooking methods and brand names of all items are used.
Administered between screening and actual test session, to be completed on 2 weekdays and 1 weekend.
Gastrointestinal Symptom Rating Scale (GSRS)
Aikaikkuna: Baseline measurement administered once during screening.
The Gastrointestinal Symptom Rating Scale (GSRS) is a validated 15-item questionnaire used to assess the presence and severity of common digestive issues across five key areas: abdominal pain, reflux, diarrhea, constipation, and indigestion. Participants rate each symptom on a 7-point Likert scale-ranging from "no discomfort" to "very severe discomfort"-to provide a quantifiable measurement of their gastrointestinal well-being.
Baseline measurement administered once during screening.
Council on Nutrition Appetite Questionnaire (CNAQ)
Aikaikkuna: Baseline measurement administered once during screening, takes approximately 5-10 minutes
The Council on Nutrition Appetite Questionnaire (CNAQ) is a brief, 8-item screening tool designed to predict future weight loss by assessing a participant's appetite and dietary habits. It asks about sensations like hunger, how quickly a participant feel full, and how food tastes to determine if a participant is at risk for nutritional deficiencies or significant weight changes over the coming months.
Baseline measurement administered once during screening, takes approximately 5-10 minutes
Pittsburgh Sleep Quality Index (PSQI)
Aikaikkuna: Baseline measurement administered once during screening, takes approximately 5-10 minutes
The Pittsburgh Sleep Quality Index (PSQI) is a validated 19-item questionnaire used to measure sleep quality and disturbances over a one-month timeframe. It evaluates seven key areas-including sleep duration, how long it takes to fall asleep, sleep disruptions, and daytime tiredness-to generate a single overall score that differentiates between "good" and "poor" sleepers in clinical research.
Baseline measurement administered once during screening, takes approximately 5-10 minutes
Geriatric Depression Scale (GDS)
Aikaikkuna: Administered once during screening, takes approximately 5 minutes
The Geriatric Depression Scale (GDS) is a 30-item questionnaire-often shortened to a 15-item version-specifically designed to screen for depression in older adults. Unlike general depression scales, it uses a simple "yes" or "no" format and focuses primarily on psychological and mood-related symptoms rather than physical complaints (like aches or fatigue), which can often overlap with normal aging or other medical conditions.
Administered once during screening, takes approximately 5 minutes
Dutch Eating Behavior Questionnaire (DEBQ)
Aikaikkuna: Baseline measurement administered once during screening, takes approximately 10 minutes
The Dutch Eating Behavior Questionnaire (DEBQ) is a 33-item psychometric scale used to assess the distinct psychological factors and eating styles that can lead to overeating or weight gain. It breaks eating behaviors down into three core subscales - emotional eating, external eating and restrained eating.
Baseline measurement administered once during screening, takes approximately 10 minutes
Leeds Food Preference Questionnaire (LFPQ)
Aikaikkuna: Baseline measurement administered once during screening, takes approximately 10-15 minutes
The Leeds Food Preference Questionnaire (LFPQ) is a computer-based tool used in behavioral research to measure different psychological components of food preference and appetite. It uses a series of food images to evaluate two distinct aspects of food reward: explicit liking and implicit wanting. The tool categorizes these preferences across different food characteristics, specifically comparing high-fat vs. low-fat foods, and sweet vs. savory tastes.
Baseline measurement administered once during screening, takes approximately 10-15 minutes
Three-Factor Eating Questionnaire (TFEQ)
Aikaikkuna: Baseline measurement administered once during screening, takes approximately 10 minutes
The Three-Factor Eating Questionnaire (TFEQ) is a validated psychometric tool used to measure three distinct dimensions of human eating behavior and cognitive dietary control. It evaluates eating habits across three primary subscales: cognitive restraint, disinhibition and hunger
Baseline measurement administered once during screening, takes approximately 10 minutes
International Physical Activity Questionnaire (IPAQ)
Aikaikkuna: Baseline measurement administered once during screening, takes approximately 10 minutes
The International Physical Activity Questionnaire (IPAQ) is a validated tool that measures a person's physical activity levels over a 7-day period. It records the total time spent across four distinct intensities: vigorous activity (like running or heavy lifting), moderate activity (like steady cycling), walking, and weekday sitting time. These tracked minutes are converted into a standard metabolic score (MET-minutes/week), which is then used to classify an individual's overall physical activity level into one of three distinct categories: Low, Moderate, or High.
Baseline measurement administered once during screening, takes approximately 10 minutes

Yhteistyökumppanit ja tutkijat

Täältä löydät tähän tutkimukseen osallistuvat ihmiset ja organisaatiot.

Sponsori

Singapore Institute of Food and Biotechnology Innovation

Tutkijat

  • Päätutkija: Darel Toh, PhD, Clinical Nutrition Research Centre

Julkaisuja ja hyödyllisiä linkkejä

Tutkimusta koskevien tietojen syöttämisestä vastaava henkilö toimittaa nämä julkaisut vapaaehtoisesti. Nämä voivat koskea mitä tahansa tutkimukseen liittyvää.

Yleiset julkaisut

Opintojen ennätyspäivät

Nämä päivämäärät seuraavat ClinicalTrials.gov-sivustolle lähetettyjen tutkimustietueiden ja yhteenvetojen edistymistä. National Library of Medicine (NLM) tarkistaa tutkimustiedot ja raportoidut tulokset varmistaakseen, että ne täyttävät tietyt laadunvalvontastandardit, ennen kuin ne julkaistaan ​​julkisella verkkosivustolla.

Opi tärkeimmät päivämäärät

Opiskelun aloitus (Arvioitu)

Maanantai 1. kesäkuuta 2026

Ensisijainen valmistuminen (Arvioitu)

Lauantai 1. elokuuta 2026

Opintojen valmistuminen (Arvioitu)

Torstai 1. lokakuuta 2026

Opintoihin ilmoittautumispäivät

Ensimmäinen lähetetty

Keskiviikko 20. toukokuuta 2026

Ensimmäinen toimitettu, joka täytti QC-kriteerit

Keskiviikko 3. kesäkuuta 2026

Ensimmäinen Lähetetty (Todellinen)

Tiistai 9. kesäkuuta 2026

Tutkimustietojen päivitykset

Viimeisin päivitys julkaistu (Todellinen)

Tiistai 9. kesäkuuta 2026

Viimeisin lähetetty päivitys, joka täytti QC-kriteerit

Keskiviikko 3. kesäkuuta 2026

Viimeksi vahvistettu

Maanantai 1. kesäkuuta 2026

Lisää tietoa

Tähän tutkimukseen liittyvät termit

Avainsanat

Muita asiaankuuluvia MeSH-ehtoja

Muut tutkimustunnusnumerot

  • 2025-133

Yksittäisten osallistujien tietojen suunnitelma (IPD)

Aiotko jakaa yksittäisten osallistujien tietoja (IPD)?

EI

Lääke- ja laitetiedot, tutkimusasiakirjat

Tutkii yhdysvaltalaista FDA sääntelemää lääkevalmistetta

Ei

Tutkii yhdysvaltalaista FDA sääntelemää laitetuotetta

Ei

Nämä tiedot haettiin suoraan verkkosivustolta clinicaltrials.gov ilman muutoksia. Jos sinulla on pyyntöjä muuttaa, poistaa tai päivittää tutkimustietojasi, ota yhteyttä register@clinicaltrials.gov. Heti kun muutos on otettu käyttöön osoitteessa clinicaltrials.gov, se päivitetään automaattisesti myös verkkosivustollemme .

Tilaa