Atropine Eye Drops for Watery Eyes (Excessive Tearing)

You may be able to join if you:

• Are 18 years or older
• Have vision of 20/200 or better in at least one eye
• Have watery eyes (epiphora) bad enough to need wiping or dabbing at least twice a day
• Have watering caused by a functional/idiopathic, gustatory ("crocodile tears"), environmentally triggered (reflex), or obstructive cause - in one or both eyes
• Have a healthy eye surface, with no significant dry eye, active eye infection, or active eye inflammation
• Have adequate eyelid position and tone, where surgery is not the main treatment needed and reducing tear production is likely to help
• Are willing and able to put drops in your eye(s) once each night for 7 days and attend the study visits
• Can understand and follow the study procedures and communicate with study staff (an interpreter is allowed)

You will not be able to join if you:

• Have significant dry eye disease
• Have had an active eye infection within the past 30 days
• Have an active tear-sac infection, or a blocked tear duct that needs urgent surgery (a blocked tear duct that does not need surgery is allowed)
• Currently use eye drops that affect tear production or eye-surface testing, unless you are willing to stop them for the study
• Are allergic to, or should not take, atropine, similar (anticholinergic) medicines, or any ingredient in the study drops
• Have narrow-angle or angle-closure glaucoma, where dilating the pupil would not be safe for you
• Are pregnant or breastfeeding
• Are taking part in another interventional study, or took part in one within 30 days before screening
• Have any condition that, in the doctor's judgment, would make it unsafe for you to join or hard to follow the study