Effects of Adaptive Difficulty Computerized Cognitive Training on Cognitive Function Improvement in Older Adults With Mild Cognitive Impairment
Tutkimuksen yleiskatsaus
Tila
Yksityiskohtainen kuvaus
With the rapid aging of the global population, mild cognitive impairment (MCI) has become a critical stage for dementia prevention and early intervention. Cognitive training is recognized as one of the most effective non-pharmacological interventions for individuals with MCI. Among various approaches, adaptive computerized cognitive training (CCT) can dynamically adjust task difficulty according to an individual's performance, thereby improving training personalization, engagement, and adherence. However, evidence regarding the optimal maintenance training frequency and the long-term sustainability of cognitive benefits remains limited.
This study adopts a quasi-experimental design and will recruit community-dwelling adults aged 60 years and older with MCI from three communities in Shenyang, Liaoning Province, China. All participants will complete a 12-week adaptive computerized cognitive training program using the Heling Brain Planet WeChat mini-program, with training sessions lasting 30 minutes, three times per week. After the initial intervention, participants will be assigned to either a high-frequency maintenance training group, which will continue training three times per week, or a training discontinuation group, which will receive routine community health management only. Follow-up cognitive assessments will be conducted after the intervention and during the follow-up period.
The primary outcome will be global cognitive function assessed by the Montreal Cognitive Assessment (MoCA). Secondary outcomes will include memory (Auditory Verbal Learning Test, AVLT), attention (Trail Making Test Part A, TMT-A), executive function (Stroop Color-Word Test), language (Boston Naming Test, BNT), visuospatial ability (Clock Drawing Test, CDT), and activities of daily living (ADL). The effects of different maintenance training frequencies on cognitive improvement and the persistence of intervention benefits will be compared.
This study is expected to evaluate the effectiveness of adaptive computerized cognitive training for improving cognitive function in community-dwelling older adults with MCI and to determine whether continued maintenance training can prolong cognitive benefits. The findings will provide evidence for optimizing community-based digital cognitive training programs and developing sustainable intervention strategies for the long-term management of older adults with MCI.
Opintotyyppi
Ilmoittautuminen (Arvioitu)
Vaihe
- Ei sovellettavissa
Yhteystiedot ja paikat
Opiskeluyhteys
- Nimi: Ziyi Zhang
- Puhelinnumero: +8613314010321
- Sähköposti: zhangziyi202058@163.com
Opiskelupaikat
-
-
Liaoning
-
Shenyang, Liaoning, Kiina, 110000
- Ren'ai Changwan Community Elderly Care Service Station, Dadong
-
Ottaa yhteyttä:
- Yu Liu, PhD
- Puhelinnumero: +8618193218315
- Sähköposti: 2968500699@qq.com
-
-
Osallistumiskriteerit
Kelpoisuusvaatimukset
Opintokelpoiset iät
- Aikuinen
- Vanhempi Aikuinen
Hyväksyy terveitä vapaaehtoisia
Kuvaus
Inclusion Criteria:
- Age >= 60 years;
- Planning to reside in the community for at least 12 months, with no intention to move into a nursing home;
- No clinical diagnosis of dementia;
- Meeting the diagnostic criteria for mild cognitive impairment (MCI) as defined in the Chinese Expert Consensus on the Diagnosis and Treatment of Alzheimer's Disease-Related Mild Cognitive Impairment (2021), The cut-off scores for the Beijing version of the Montreal Cognitive Assessment (MoCA) were adjusted for educational level: <=13 for junior high school or below, <=19 for high school, and <=24 for college education or above. Mini-Mental State Examination (MMSE) score >= 24; Activities of Daily Living (ADL) score <23.
- Able to use a mobile application (mini program) to perform cognitive training.
Exclusion Criteria:
- Individuals unable to complete the questionnaires due to hearing or visual impairments;
- Those with other organic diseases of the central nervous system, such as brain tumors, epilepsy, or Parkinson's disease;
- Those diagnosed with severe mental disorders, such as schizophrenia, depression, or anxiety disorders.
Opintosuunnitelma
Miten tutkimus on suunniteltu?
Suunnittelun yksityiskohdat
- Ensisijainen käyttötarkoitus: Hoito
- Jako: Ei satunnaistettu
- Inventiomalli: Rinnakkaistehtävä
- Naamiointi: Yksittäinen
Aseet ja interventiot
Osallistujaryhmä / Arm |
Interventio / Hoito |
|---|---|
|
Kokeellinen: High-Frequency Maintenance Training
Participants will receive adaptive computerized cognitive training using the Heling Brain Planet WeChat mini-program.
During the initial intervention phase, participants will complete training sessions three times per week for 30 minutes per session over 12 weeks.
After the initial intervention, participants will continue maintenance training three times per week until the end of the follow-up period.
The training program automatically adjusts task difficulty according to individual performance and includes exercises targeting attention, memory, executive function, language, visuospatial ability, and other cognitive domains.
|
Participants receive adaptive computerized cognitive training delivered through the Heling Brain Planet WeChat mini- program.
The intervention consists of individualized cognitive exercises targeting multiple cognitive domains, including attention, memory, executive function, language, visuospatial ability, perceptual-motor function, and social cognition.
The training difficulty is automatically adjusted according to each participant's performance to provide personalized cognitive stimulation.
During the initial intervention phase, all participants complete 30-minute training sessions three times per week for 3 months.
After the initial intervention, participants choose to continue training receive maintenance adaptive computerized cognitive training.
Participants receive adaptive computerized cognitive training delivered through the Heling Brain Planet WeChat mini- program.
The intervention consists of individualized cognitive exercises targeting multiple cognitive domains, including attention, memory, executive function, language, visuospatial ability, perceptual-motor function, and social cognition.
The training difficulty is automatically adjusted according to each participant's performance to provide personalized cognitive stimulation.
During the initial intervention phase, all participants complete 30-minute training sessions three times per week for 3 months.
After the initial intervention, participants not to continue discontinue the intervention and undergo follow-up assessments only.
|
|
Muut: Training Discontinuation Group
Participants will receive the same 12-week adaptive computerized cognitive training program during the initial intervention phase.
After completing the initial intervention, no further computerized cognitive training will be provided.
Participants will continue to receive routine community health management and will complete follow-up cognitive assessments according to the study schedule.
|
Participants receive adaptive computerized cognitive training delivered through the Heling Brain Planet WeChat mini- program.
The intervention consists of individualized cognitive exercises targeting multiple cognitive domains, including attention, memory, executive function, language, visuospatial ability, perceptual-motor function, and social cognition.
The training difficulty is automatically adjusted according to each participant's performance to provide personalized cognitive stimulation.
During the initial intervention phase, all participants complete 30-minute training sessions three times per week for 3 months.
After the initial intervention, participants choose to continue training receive maintenance adaptive computerized cognitive training.
Participants receive adaptive computerized cognitive training delivered through the Heling Brain Planet WeChat mini- program.
The intervention consists of individualized cognitive exercises targeting multiple cognitive domains, including attention, memory, executive function, language, visuospatial ability, perceptual-motor function, and social cognition.
The training difficulty is automatically adjusted according to each participant's performance to provide personalized cognitive stimulation.
During the initial intervention phase, all participants complete 30-minute training sessions three times per week for 3 months.
After the initial intervention, participants not to continue discontinue the intervention and undergo follow-up assessments only.
|
Mitä tutkimuksessa mitataan?
Ensisijaiset tulostoimenpiteet
Tulosmittaus |
Aikaikkuna |
|---|---|
|
Change in global cognitive function assessed by the Montreal Cognitive Assessment (MoCA)
Aikaikkuna: Baseline, Month 3, Month 4, and Month 6
|
Baseline, Month 3, Month 4, and Month 6
|
Toissijaiset tulostoimenpiteet
Tulosmittaus |
Aikaikkuna |
|---|---|
|
Change in cognitive function assessed by the Mini-Mental State Examination (MMSE)
Aikaikkuna: Baseline, Month 3, Month 4, and Month 6
|
Baseline, Month 3, Month 4, and Month 6
|
|
Change in language function assessed by the Boston Naming Test (BNT)
Aikaikkuna: Baseline, Month 3, Month 4, and Month 6
|
Baseline, Month 3, Month 4, and Month 6
|
|
Change in attention assessed by the Trail Making Test Part A (TMT-A)
Aikaikkuna: Baseline, Month 3, Month 4, and Month 6
|
Baseline, Month 3, Month 4, and Month 6
|
|
Change in executive function assessed by the Stroop Color-Word Test
Aikaikkuna: Baseline, Month 3, Month 4, and Month 6
|
Baseline, Month 3, Month 4, and Month 6
|
|
Change in visuospatial function assessed by the Clock Drawing Test (CDT)
Aikaikkuna: Baseline, Month 3, Month 4, and Month 6
|
Baseline, Month 3, Month 4, and Month 6
|
|
Change in activities of daily living assessed by the Activities of Daily Living (ADL) scale
Aikaikkuna: Baseline, Month 3, Month 4, and Month 6
|
Baseline, Month 3, Month 4, and Month 6
|
Yhteistyökumppanit ja tutkijat
Sponsori
Opintojen ennätyspäivät
Opi tärkeimmät päivämäärät
Opiskelun aloitus (Arvioitu)
Ensisijainen valmistuminen (Arvioitu)
Opintojen valmistuminen (Arvioitu)
Opintoihin ilmoittautumispäivät
Ensimmäinen lähetetty
Ensimmäinen toimitettu, joka täytti QC-kriteerit
Ensimmäinen Lähetetty (Todellinen)
Tutkimustietojen päivitykset
Viimeisin päivitys julkaistu (Todellinen)
Viimeisin lähetetty päivitys, joka täytti QC-kriteerit
Viimeksi vahvistettu
Lisää tietoa
Tähän tutkimukseen liittyvät termit
Muita asiaankuuluvia MeSH-ehtoja
Muut tutkimustunnusnumerot
- China Medical University (china medical university and hospital)
Yksittäisten osallistujien tietojen suunnitelma (IPD)
Aiotko jakaa yksittäisten osallistujien tietoja (IPD)?
Lääke- ja laitetiedot, tutkimusasiakirjat
Tutkii yhdysvaltalaista FDA sääntelemää lääkevalmistetta
Tutkii yhdysvaltalaista FDA sääntelemää laitetuotetta
Nämä tiedot haettiin suoraan verkkosivustolta clinicaltrials.gov ilman muutoksia. Jos sinulla on pyyntöjä muuttaa, poistaa tai päivittää tutkimustietojasi, ota yhteyttä register@clinicaltrials.gov. Heti kun muutos on otettu käyttöön osoitteessa clinicaltrials.gov, se päivitetään automaattisesti myös verkkosivustollemme .