Rehabilitation of Visual Attention Following mTBI
11 mars 2019 mis à jour par: United States Naval Medical Center, San Diego
The objective of this proposal is to evaluate the effectiveness of rehabilitation for visual attention deficits in U.S. military service members across three programs: Visual Attention and Working Memory Programs (UCR Games), Speech Pathologist-Directed Treatment, and General Cognitive Rehabilitation Games (Lumosity).
In addition to the above prospective component, this study also has a retrospective component in which archival data collected from routine clinical care will be examined for analysis. The investigators hope to gain a better understanding of the unique and cumulative influence different cognitive rehabilitation programs have on improving attention complaints in mTBI.
Aperçu de l'étude
Statut
Inconnue
Les conditions
Description détaillée
Mild traumatic brain injury (mTBI) is one of the most commonly sustained combat-related injuries. Complaints of poor attention often follow mTBI and can become chronic in some individuals. Chronic attention complaints have traditionally been treated with cognitive rehabilitation by speech pathologists. Recent research has shown that computerized programs may add additional value either independently or in conjunction with traditional therapies. Researchers at UC Riverside have already completed research showing that vision training, using the ULTIMEYES program that they created, led to improved vision both on standard assessments, such as reading eye-charts, and in real world skills, such as reading and playing baseball. This program is designed to broadly improve basic aspects of vision, such as visual acuity and contrast sensitivity, as well as high-level vision, such as attention. Furthermore, an associated memory training task (Recall The Game) shows improvements in memory tasks and transfer to skills such as fluid intelligence.
The objective of this proposal is to evaluate the effectiveness of rehabilitation for visual attention deficits in U.S. military service members across three programs:
- Visual Attention and Memory Program (UCR Games)
- Cognitive and Psychological Based Rehabilitation (Speech Pathologist-Directed Therapy)
- General Cognitive Rehabilitation Games (Lumosity [2])
The investigators hope to gain a better understanding of the unique and cumulative influence of different cognitive rehabilitation programs on improving attention complaints in mTBI. This proposal contains both retrospective and prospective components.
The retrospective component consists of examining archival data from Lumosity, previously collected as part of routine clinical care. The data contain pre- and post-assessments of post-concussive symptoms, symptom frequency, and cognitive testing. The investigators expect that data analysis will reveal evidence of improvement in severity of post-concussive symptoms, in frequency of troublesome cognitive problems, and in performance on neuropsychological tests when pre- and post-assessments are compared.
The prospective component will consist of 120 service members with mTBI who have ongoing attention complaints and are more than three months post-injury. Each service member will be randomly assigned to one of four arms, differentiated only by the specific computer-based rehabilitation program used. All individuals will also be treated per current standard of care guidelines by a speech pathologist.
Each of the four arms will be comprised of 30 participants. A cognitive testing battery will be administered to each participant before and after implementation of each intervention. The cognitive testing battery form will vary based on time of administration in order to control for practice effects. Performance on the cognitive testing battery and self-report measures will be compared between and within the three arms.
This research will help the military to identify the best cognitive rehabilitation treatment program to address ongoing attention complaints following mTBI.
Type d'étude
Interventionnel
Inscription (Anticipé)
120
Phase
- N'est pas applicable
Contacts et emplacements
Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.
Lieux d'étude
-
-
California
-
San Diego, California, États-Unis, 92134
- Recrutement
- Naval Medical Center San Diego
-
Contact:
- Brittany Powell, MD
-
-
Critères de participation
Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.
Critère d'éligibilité
Âges éligibles pour étudier
18 ans et plus (Adulte, Adulte plus âgé)
Accepte les volontaires sains
Non
Sexes éligibles pour l'étude
Tout
La description
Inclusion Criteria:
- Closed TBI
- Have sufficient information available that we can confidently classify severity as mild based on DOD/VA criteria
- Time tested post-injury > 3 months
- Ongoing attention complaints
Exclusion Criteria:
- Moderate/Severe TBI
- Penetrating TBI
- Attention Deficit Hyperactivity Disorder
- Learning Disorder
- Diagnosed medical condition that is expected to impact cognitive performance (i.e. Multiple Sclerosis, Stroke)
Plan d'étude
Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Traitement
- Répartition: Randomisé
- Modèle interventionnel: Affectation parallèle
- Masquage: Seul
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
|
Expérimental: A: UCR Games→SP-Directed Therapy
Participants in Arm A will first participate in Visual Attention Program (UCR Games) followed by Speech Pathologist-Directed Therapy with assessment sessions prior to and following each treatment intervention.
|
This program is an individual-directed computerized cognitive rehabilitation program based on perceptual learning approaches to enhance visual attention.
Training incorporates a diverse set of stimuli, optimized stimulus presentation, multisensory facilitation, and consistently reinforcing training stimuli.
This will be completed in a group setting with an instructor available to facilitate questions.
This is a speech pathologist-directed arm and will provide a traditional clinician-directed individualized cognitive rehabilitation program.
Cognitive treatment is a systematic, functionally oriented program of therapeutic activities that focuses on strengthening previously learned patterns of behavior, establishing new patterns through use of internal and external compensatory cognitive strategies, and enabling the individual to adapt to the changes in his or her revised approaches to cognitive functioning.
Increased performance success is reinforced through repetition, errorless learning, and gradually increasing task stimuli and complexity in a structured systematic approach.
|
|
Expérimental: B: Lumosity→SP-Directed Therapy
Participants in Arm B will first participate in General Cognitive Rehabilitation Games (Lumosity) followed by Speech Pathologist-Directed Therapy with assessment sessions prior to and following each treatment intervention.
|
This is a speech pathologist-directed arm and will provide a traditional clinician-directed individualized cognitive rehabilitation program.
Cognitive treatment is a systematic, functionally oriented program of therapeutic activities that focuses on strengthening previously learned patterns of behavior, establishing new patterns through use of internal and external compensatory cognitive strategies, and enabling the individual to adapt to the changes in his or her revised approaches to cognitive functioning.
Increased performance success is reinforced through repetition, errorless learning, and gradually increasing task stimuli and complexity in a structured systematic approach.
Lumosity is a commercially available computerized program purported to enhance cognitive functioning through a variety of computerized programs that utilize various cognitive abilities.
|
|
Expérimental: C: SP-Directed Therapy→UCR Games
Participants in Arm C will first participate in Speech Pathologist-Directed Therapy followed by Visual Attention Program (UCR Games) with assessment sessions prior to and following each treatment intervention.
|
This program is an individual-directed computerized cognitive rehabilitation program based on perceptual learning approaches to enhance visual attention.
Training incorporates a diverse set of stimuli, optimized stimulus presentation, multisensory facilitation, and consistently reinforcing training stimuli.
This will be completed in a group setting with an instructor available to facilitate questions.
This is a speech pathologist-directed arm and will provide a traditional clinician-directed individualized cognitive rehabilitation program.
Cognitive treatment is a systematic, functionally oriented program of therapeutic activities that focuses on strengthening previously learned patterns of behavior, establishing new patterns through use of internal and external compensatory cognitive strategies, and enabling the individual to adapt to the changes in his or her revised approaches to cognitive functioning.
Increased performance success is reinforced through repetition, errorless learning, and gradually increasing task stimuli and complexity in a structured systematic approach.
|
|
Expérimental: D: SP-Directed Therapy→Lumosity
Participants in Arm D will first participate in Speech Pathologist-Directed Therapy followed by General Cognitive Rehabilitation Games (Lumosity) with assessment sessions prior to and following each treatment intervention.
|
This is a speech pathologist-directed arm and will provide a traditional clinician-directed individualized cognitive rehabilitation program.
Cognitive treatment is a systematic, functionally oriented program of therapeutic activities that focuses on strengthening previously learned patterns of behavior, establishing new patterns through use of internal and external compensatory cognitive strategies, and enabling the individual to adapt to the changes in his or her revised approaches to cognitive functioning.
Increased performance success is reinforced through repetition, errorless learning, and gradually increasing task stimuli and complexity in a structured systematic approach.
Lumosity is a commercially available computerized program purported to enhance cognitive functioning through a variety of computerized programs that utilize various cognitive abilities.
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Post-Concussion Cognitive Symptoms
Délai: Two Months
|
Comparison of performance on pre- and post-intervention neuropsychological testing battery.
|
Two Months
|
|
Severity of Post-Concussive Symptoms
Délai: Two Months
|
Comparison of self-reported symptoms on pre- and post-intervention assessment.
|
Two Months
|
Collaborateurs et enquêteurs
C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.
Les enquêteurs
- Chercheur principal: Brittany E Powell, MD, United States Naval Medical Center, San Diego
Publications et liens utiles
La personne responsable de la saisie des informations sur l'étude fournit volontairement ces publications. Il peut s'agir de tout ce qui concerne l'étude.
Publications générales
- Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13. doi: 10.1046/j.1525-1497.2001.016009606.x.
- Klingberg T, Fernell E, Olesen PJ, Johnson M, Gustafsson P, Dahlstrom K, Gillberg CG, Forssberg H, Westerberg H. Computerized training of working memory in children with ADHD--a randomized, controlled trial. J Am Acad Child Adolesc Psychiatry. 2005 Feb;44(2):177-86. doi: 10.1097/00004583-200502000-00010.
- Jaeggi SM, Buschkuehl M, Jonides J, Perrig WJ. Improving fluid intelligence with training on working memory. Proc Natl Acad Sci U S A. 2008 May 13;105(19):6829-33. doi: 10.1073/pnas.0801268105. Epub 2008 Apr 28.
- Deveau J, Lovcik G, Seitz AR. Broad-based visual benefits from training with an integrated perceptual-learning video game. Vision Res. 2014 Jun;99:134-40. doi: 10.1016/j.visres.2013.12.015. Epub 2014 Jan 6.
- Spitzer RL, Kroenke K, Williams JB. Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA. 1999 Nov 10;282(18):1737-44. doi: 10.1001/jama.282.18.1737.
- Smith GE, Housen P, Yaffe K, Ruff R, Kennison RF, Mahncke HW, Zelinski EM. A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study. J Am Geriatr Soc. 2009 Apr;57(4):594-603. doi: 10.1111/j.1532-5415.2008.02167.x. Epub 2009 Feb 9.
- Bogner J, Corrigan JD. Reliability and predictive validity of the Ohio State University TBI identification method with prisoners. J Head Trauma Rehabil. 2009 Jul-Aug;24(4):279-91. doi: 10.1097/HTR.0b013e3181a66356.
- Corrigan JD, Bogner J. Initial reliability and validity of the Ohio State University TBI Identification Method. J Head Trauma Rehabil. 2007 Nov-Dec;22(6):318-29. doi: 10.1097/01.HTR.0000300227.67748.77.
- Hoge CW, McGurk D, Thomas JL, Cox AL, Engel CC, Castro CA. Mild traumatic brain injury in U.S. Soldiers returning from Iraq. N Engl J Med. 2008 Jan 31;358(5):453-63. doi: 10.1056/NEJMoa072972. Epub 2008 Jan 30.
- Green CS, Bavelier D. Action video game modifies visual selective attention. Nature. 2003 May 29;423(6939):534-7. doi: 10.1038/nature01647.
- Franceschini S, Gori S, Ruffino M, Viola S, Molteni M, Facoetti A. Action video games make dyslexic children read better. Curr Biol. 2013 Mar 18;23(6):462-6. doi: 10.1016/j.cub.2013.01.044. Epub 2013 Feb 28.
- Lange RT, Brickell TA, Kennedy JE, Bailie JM, Sills C, Asmussen S, Amador R, Dilay A, Ivins B, French LM. Factors influencing postconcussion and posttraumatic stress symptom reporting following military-related concurrent polytrauma and traumatic brain injury. Arch Clin Neuropsychol. 2014 Jun;29(4):329-47. doi: 10.1093/arclin/acu013. Epub 2014 Apr 9.
- Li R, Polat U, Makous W, Bavelier D. Enhancing the contrast sensitivity function through action video game training. Nat Neurosci. 2009 May;12(5):549-51. doi: 10.1038/nn.2296. Epub 2009 Mar 29.
- Palmese CA, Raskin SA. The rehabilitation of attention in individuals with mild traumatic brain injury, using the APT-II programme. Brain Inj. 2000 Jun;14(6):535-48. doi: 10.1080/026990500120448.
- Green CS, Bavelier D. Action-video-game experience alters the spatial resolution of vision. Psychol Sci. 2007 Jan;18(1):88-94. doi: 10.1111/j.1467-9280.2007.01853.x. Erratum In: Psychol Sci. 2019 Dec;30(12):1790.
- Jaeggi SM, Buschkuehl M, Jonides J, Shah P. Short- and long-term benefits of cognitive training. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10081-6. doi: 10.1073/pnas.1103228108. Epub 2011 Jun 13.
- Gronwall DM. Paced auditory serial-addition task: a measure of recovery from concussion. Percept Mot Skills. 1977 Apr;44(2):367-73. doi: 10.2466/pms.1977.44.2.367.
- Fann JR, Bombardier CH, Dikmen S, Esselman P, Warms CA, Pelzer E, Rau H, Temkin N. Validity of the Patient Health Questionnaire-9 in assessing depression following traumatic brain injury. J Head Trauma Rehabil. 2005 Nov-Dec;20(6):501-11. doi: 10.1097/00001199-200511000-00003.
- Kolitz BP, Vanderploeg RD, Curtiss G. Development of the Key Behaviors Change Inventory: a traumatic brain injury behavioral outcome assessment instrument. Arch Phys Med Rehabil. 2003 Feb;84(2):277-84. doi: 10.1053/apmr.2003.50100.
- Schneiderman AI, Braver ER, Kang HK. Understanding sequelae of injury mechanisms and mild traumatic brain injury incurred during the conflicts in Iraq and Afghanistan: persistent postconcussive symptoms and posttraumatic stress disorder. Am J Epidemiol. 2008 Jun 15;167(12):1446-52. doi: 10.1093/aje/kwn068. Epub 2008 Apr 17.
- Karni A, Sagi D. Where practice makes perfect in texture discrimination: evidence for primary visual cortex plasticity. Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4966-70. doi: 10.1073/pnas.88.11.4966.
- Yeager DE, Magruder KM, Knapp RG, Nicholas JS, Frueh BC. Performance characteristics of the posttraumatic stress disorder checklist and SPAN in Veterans Affairs primary care settings. Gen Hosp Psychiatry. 2007 Jul-Aug;29(4):294-301. doi: 10.1016/j.genhosppsych.2007.03.004.
- Stepankova H, Lukavsky J, Buschkuehl M, Kopecek M, Ripova D, Jaeggi SM. The malleability of working memory and visuospatial skills: a randomized controlled study in older adults. Dev Psychol. 2014 Apr;50(4):1049-1059. doi: 10.1037/a0034913. Epub 2013 Nov 11.
- Green CS, Pouget A, Bavelier D. Improved probabilistic inference as a general learning mechanism with action video games. Curr Biol. 2010 Sep 14;20(17):1573-9. doi: 10.1016/j.cub.2010.07.040.
- Deveau J, Ozer DJ, Seitz AR. Improved vision and on-field performance in baseball through perceptual learning. Curr Biol. 2014 Feb 17;24(4):R146-7. doi: 10.1016/j.cub.2014.01.004. No abstract available.
- Lumosity. Available from: http://www.lumosity.com.
- Carey ME. Learning from traditional combat mortality and morbidity data used in the evaluation of combat medical care. Mil Med. 1987 Jan;152(1):6-13. No abstract available.
- Schwab KA, Ivins B, Cramer G, Johnson W, Sluss-Tiller M, Kiley K, Lux W, Warden D. Screening for traumatic brain injury in troops returning from deployment in Afghanistan and Iraq: initial investigation of the usefulness of a short screening tool for traumatic brain injury. J Head Trauma Rehabil. 2007 Nov-Dec;22(6):377-89. doi: 10.1097/01.HTR.0000300233.98242.87.
- Terrio H, Brenner LA, Ivins BJ, Cho JM, Helmick K, Schwab K, Scally K, Bretthauer R, Warden D. Traumatic brain injury screening: preliminary findings in a US Army Brigade Combat Team. J Head Trauma Rehabil. 2009 Jan-Feb;24(1):14-23. doi: 10.1097/HTR.0b013e31819581d8.
- Report to Congress on Mild Traumatic Brain Injury in the United States: Steps to Prevent a Serious Public Health Problem, N.C.f.I.P.a. Control, Editor 2003, Center for Disease Control Prevention: Atlanta, GA.
- Binder LM, Rohling ML, Larrabee GJ. A review of mild head trauma. Part I: Meta-analytic review of neuropsychological studies. J Clin Exp Neuropsychol. 1997 Jun;19(3):421-31. doi: 10.1080/01688639708403870.
- Zakzanis, K.K., L. Leach, and E. Kaplan, Neuropsychological differential diagnosis1999: Swets & Zeitlinger Publishers.
- Belanger HG, Curtiss G, Demery JA, Lebowitz BK, Vanderploeg RD. Factors moderating neuropsychological outcomes following mild traumatic brain injury: a meta-analysis. J Int Neuropsychol Soc. 2005 May;11(3):215-27. doi: 10.1017/S1355617705050277.
- Belanger HG, Vanderploeg RD. The neuropsychological impact of sports-related concussion: a meta-analysis. J Int Neuropsychol Soc. 2005 Jul;11(4):345-57. doi: 10.1017/s1355617705050411.
- Tsaousides, T. and W.A. Gordon, Neuropsychological interventions following traumatic brain injury, in Traumatic Brain Injury: Rehabilitative Treatment and Case Management, M.J. Ashley, Editor 2010, CRC Press: Boca Raton, FL.
- Sohlberg MM, Mateer CA. Improving attention and managing attentional problems. Adapting rehabilitation techniques to adults with ADD. Ann N Y Acad Sci. 2001 Jun;931:359-75.
- Sohlberg, M.M. and C.A. Mateer, Attention Process Training-3 (APT-3): A Direct Attention Training Program for the Remediation of the Attention Deficits: APT-3 Manual, 2010, Lash & Associates Publishing/Training Inc.: Youngsville, North Carolina.
- Ben-Yishay, Y., E.B. Piasetsky, and J. Rattok, A systematic method for ameliorating disorders in basic attention. 1987.
- Fasotti, L., et al., Time pressure management as a compensatory strategy training after closed head injury. Neuropsychological Rehabilitation, 2000. 10(1): p. 47-65.
- Sinotte MP, Coelho CA. Attention training for reading impairment in mild aphasia: a follow-up study. NeuroRehabilitation. 2007;22(4):303-10.
- Tiersky LA, Anselmi V, Johnston MV, Kurtyka J, Roosen E, Schwartz T, Deluca J. A trial of neuropsychologic rehabilitation in mild-spectrum traumatic brain injury. Arch Phys Med Rehabil. 2005 Aug;86(8):1565-74. doi: 10.1016/j.apmr.2005.03.013.
- Cicerone KD. Remediation of "working attention" in mild traumatic brain injury. Brain Inj. 2002 Mar;16(3):185-95. doi: 10.1080/02699050110103959.
- Fahle M. Perceptual learning: specificity versus generalization. Curr Opin Neurobiol. 2005 Apr;15(2):154-60. doi: 10.1016/j.conb.2005.03.010.
- Fiorentini A, Berardi N. Perceptual learning specific for orientation and spatial frequency. Nature. 1980 Sep 4;287(5777):43-4. doi: 10.1038/287043a0.
- Poggio T, Fahle M, Edelman S. Fast perceptual learning in visual hyperacuity. Science. 1992 May 15;256(5059):1018-21. doi: 10.1126/science.1589770.
- Seitz AR, Kim D, Watanabe T. Rewards evoke learning of unconsciously processed visual stimuli in adult humans. Neuron. 2009 Mar 12;61(5):700-7. doi: 10.1016/j.neuron.2009.01.016.
- Xiao LQ, Zhang JY, Wang R, Klein SA, Levi DM, Yu C. Complete transfer of perceptual learning across retinal locations enabled by double training. Curr Biol. 2008 Dec 23;18(24):1922-6. doi: 10.1016/j.cub.2008.10.030. Epub 2008 Dec 8.
- Hung SC, Seitz AR. Prolonged training at threshold promotes robust retinotopic specificity in perceptual learning. J Neurosci. 2014 Jun 18;34(25):8423-31. doi: 10.1523/JNEUROSCI.0745-14.2014.
- Shams L, Seitz AR. Benefits of multisensory learning. Trends Cogn Sci. 2008 Nov;12(11):411-7. doi: 10.1016/j.tics.2008.07.006.
- Shibata K, Yamagishi N, Ishii S, Kawato M. Boosting perceptual learning by fake feedback. Vision Res. 2009 Oct;49(21):2574-85. doi: 10.1016/j.visres.2009.06.009. Epub 2009 Jun 14.
- Ahissar M, Hochstein S. Task difficulty and the specificity of perceptual learning. Nature. 1997 May 22;387(6631):401-6. doi: 10.1038/387401a0.
- Seitz AR, Watanabe T. The phenomenon of task-irrelevant perceptual learning. Vision Res. 2009 Oct;49(21):2604-10. doi: 10.1016/j.visres.2009.08.003. Epub 2009 Aug 7.
- Zhang JY, Zhang GL, Xiao LQ, Klein SA, Levi DM, Yu C. Rule-based learning explains visual perceptual learning and its specificity and transfer. J Neurosci. 2010 Sep 15;30(37):12323-8. doi: 10.1523/JNEUROSCI.0704-10.2010.
- Klingberg T, Forssberg H, Westerberg H. Training of working memory in children with ADHD. J Clin Exp Neuropsychol. 2002 Sep;24(6):781-91. doi: 10.1076/jcen.24.6.781.8395.
- Lilienthal L, Tamez E, Shelton JT, Myerson J, Hale S. Dual n-back training increases the capacity of the focus of attention. Psychon Bull Rev. 2013 Feb;20(1):135-41. doi: 10.3758/s13423-012-0335-6.
- Rudebeck SR, Bor D, Ormond A, O'Reilly JX, Lee AC. A potential spatial working memory training task to improve both episodic memory and fluid intelligence. PLoS One. 2012;7(11):e50431. doi: 10.1371/journal.pone.0050431. Epub 2012 Nov 28.
- Stephenson, C.L. and D.F. Halpern, Improved matrix reasoning is limited to training on tasks with a visuospatial component. Intelligence, 2013. 41(5): p. 341-357.
- Kundu B, Sutterer DW, Emrich SM, Postle BR. Strengthened effective connectivity underlies transfer of working memory training to tests of short-term memory and attention. J Neurosci. 2013 May 15;33(20):8705-15. doi: 10.1523/JNEUROSCI.5565-12.2013. Erratum In: J Neurosci. 2013 Jun 19;33(25):10582.
- Takeuchi H, Sekiguchi A, Taki Y, Yokoyama S, Yomogida Y, Komuro N, Yamanouchi T, Suzuki S, Kawashima R. Training of working memory impacts structural connectivity. J Neurosci. 2010 Mar 3;30(9):3297-303. doi: 10.1523/JNEUROSCI.4611-09.2010.
- Schneiders JA, Opitz B, Krick CM, Mecklinger A. Separating intra-modal and across-modal training effects in visual working memory: an fMRI investigation. Cereb Cortex. 2011 Nov;21(11):2555-64. doi: 10.1093/cercor/bhr037. Epub 2011 Apr 6.
- Mullins, L., et al., Video tracking of cancellation is sensitive to acute brain impairment and disability. Neurology, 2014. 82(P3): p. 226.
- Deveau J, Jaeggi SM, Zordan V, Phung C, Seitz AR. How to build better memory training games. Front Syst Neurosci. 2015 Jan 9;8:243. doi: 10.3389/fnsys.2014.00243. eCollection 2014.
- Deveau J, Seitz AR. Applying perceptual learning to achieve practical changes in vision. Front Psychol. 2014 Oct 16;5:1166. doi: 10.3389/fpsyg.2014.01166. eCollection 2014.
- Bailie, J.M., et al., Neurobehavioral and Cognitive Impact of Mild Traumatic Brain injury: Potential Recruitment Bias, in 33rd Annual Meeting of the National Academy of Neuropsychology 2013, Archives of Clinical Neuropsychology: San Diego, CA.
- Campbell, J.S., J.H. Greenberg, and J.M. Weil, Confronting mild-TBI and co-occuring PTSD symptoms in combat deployed service members, in Traumatic Brain Injury: A Neurologic Approach to Diagnosis, Management, and Rehabilitation, J.W. Tsao, Editor 2012, Springer Press: New Yor, NY.
- Campbell, J.S., et al., Evaluation of Post-deployment Screening for Traumatic Brain Injury and Blast Exposure in a Sample of High-Risk Sailors Deployed to Iraq, in Coping with Blast-Related Traumatic Brain injury in Returning Troops2011, IOS Press: Washington, DC. p. 126-128.
- Malec, J.F., Goal attainment scaling in rehabilitation. Neuropsychological Rehabilitation, 1999. 9(3-4): p. 253-275.
- Rabin LA, Barr WB, Burton LA. Assessment practices of clinical neuropsychologists in the United States and Canada: a survey of INS, NAN, and APA Division 40 members. Arch Clin Neuropsychol. 2005 Jan;20(1):33-65. doi: 10.1016/j.acn.2004.02.005.
- Whitney KA, Shepard PH, Mariner J, Mossbarger B, Herman SM. Validity of the Wechsler Test of Adult Reading (WTAR): effort considered in a clinical sample of U.S. military veterans. Appl Neuropsychol. 2010 Jul;17(3):196-204. doi: 10.1080/09084282.2010.499787.
- Stern, R.A. and T. White, Neuropsychological Assessment Battery: Administration, scoring, and interpretation manual, 2003, Psychological Assessment Resources: Lutz, FL.
- Stern, R.A. and T. White, NAB Naming Test: Professional Manual, 2009, Psychological Assessment Resources: Lutz, FL.
- Homack S, Riccio CA. Conners' Continuous Performance Test (2nd ed.; CCPT-II). J Atten Disord. 2006 Feb;9(3):556-8. doi: 10.1177/1087054705283578. No abstract available.
- Smith, A., Symbol Digits Modalities Test: Manual, 2007, Western Psychological Services: Los Angeles.
- Weathers, F.W., J.A. Huska, and T.M. Keane, PTSD Checklist- Military Version (PCLM), 1991, National Center for PTSD- Behavioral Science Division.
- Gewirtz AH, Polusny MA, DeGarmo DS, Khaylis A, Erbes CR. Posttraumatic stress symptoms among National Guard soldiers deployed to Iraq: associations with parenting behaviors and couple adjustment. J Consult Clin Psychol. 2010 Oct;78(5):599-610. doi: 10.1037/a0020571.
- Cook JM, Elhai JD, Cassidy EL, Ruzek JI, Ram GD, Sheikh JI. Assessment of trauma exposure and post-traumatic stress in long-term care veterans: preliminary data on psychometrics and post-traumatic stress disorder prevalence. Mil Med. 2005 Oct;170(10):862-6. doi: 10.7205/milmed.170.10.862.
- Belanger HG, Kretzmer T, Vanderploeg RD, French LM. Symptom complaints following combat-related traumatic brain injury: relationship to traumatic brain injury severity and posttraumatic stress disorder. J Int Neuropsychol Soc. 2010 Jan;16(1):194-9. doi: 10.1017/S1355617709990841. Epub 2009 Sep 17.
- Polusny MA, Kehle SM, Nelson NW, Erbes CR, Arbisi PA, Thuras P. Longitudinal effects of mild traumatic brain injury and posttraumatic stress disorder comorbidity on postdeployment outcomes in national guard soldiers deployed to Iraq. Arch Gen Psychiatry. 2011 Jan;68(1):79-89. doi: 10.1001/archgenpsychiatry.2010.172.
- van Veldhoven LM, Sander AM, Struchen MA, Sherer M, Clark AN, Hudnall GE, Hannay HJ. Predictive ability of preinjury stressful life events and post-traumatic stress symptoms for outcomes following mild traumatic brain injury: analysis in a prospective emergency room sample. J Neurol Neurosurg Psychiatry. 2011 Jul;82(7):782-7. doi: 10.1136/jnnp.2010.228254. Epub 2011 Jan 17.
- Using the PTSD checklist U.S. Department of Veterans Affairs, V.N.C.f. PTSD, Editor 2012.
- Bliese PD, Wright KM, Adler AB, Cabrera O, Castro CA, Hoge CW. Validating the primary care posttraumatic stress disorder screen and the posttraumatic stress disorder checklist with soldiers returning from combat. J Consult Clin Psychol. 2008 Apr;76(2):272-81. doi: 10.1037/0022-006X.76.2.272.
- Lowe B, Spitzer RL, Grafe K, Kroenke K, Quenter A, Zipfel S, Buchholz C, Witte S, Herzog W. Comparative validity of three screening questionnaires for DSM-IV depressive disorders and physicians' diagnoses. J Affect Disord. 2004 Feb;78(2):131-40. doi: 10.1016/s0165-0327(02)00237-9.
- Williams JW Jr, Noel PH, Cordes JA, Ramirez G, Pignone M. Is this patient clinically depressed? JAMA. 2002 Mar 6;287(9):1160-70. doi: 10.1001/jama.287.9.1160.
Dates d'enregistrement des études
Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.
Dates principales de l'étude
Début de l'étude
1 mai 2016
Achèvement primaire (Anticipé)
1 octobre 2020
Achèvement de l'étude (Anticipé)
1 octobre 2020
Dates d'inscription aux études
Première soumission
21 mars 2016
Première soumission répondant aux critères de contrôle qualité
21 mars 2016
Première publication (Estimation)
25 mars 2016
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
13 mars 2019
Dernière mise à jour soumise répondant aux critères de contrôle qualité
11 mars 2019
Dernière vérification
1 mars 2019
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- NMCSD.2015.0049
Plan pour les données individuelles des participants (IPD)
Prévoyez-vous de partager les données individuelles des participants (DPI) ?
INDÉCIS
Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .