PRE-STARt Intervention - Trial of an Interactive Family Based Lifestyle Programme
14 janvier 2019 mis à jour par: University Hospitals, Leicester
Prevention Strategies for Adolescents at Risk of Diabetes - A Randomised Controlled Trial of an Interactive Family-based Lifestyle Programme
To investigate whether the interactive family based lifestyle programme leads to behaviour change at 6 months with the primary outcome being increased levels of moderate to vigorous physical activity (MVPA).
Aperçu de l'étude
Statut
Complété
Les conditions
Intervention / Traitement
Description détaillée
To investigate whether the lifestyle programme results in changes to the following outcomes 3 and 6 months after baseline assessment (Child)
- An increase in objectively measured total amount of physical activity
- An increase in the proportion meeting MVPA guidelines (measured objectively)
- Reduction in time spent sedentary (measured objectively and self-reported)
- Change in self-reported physical activity
- Reduction in measures of adiposity (body mass index percentile, per cent body fat)
- Improvement in psychological factors that may mediate physical activity participation (self-efficacy, motivation, attitudes, social support and enjoyment of physical activity; and physical self-perceptions)
- Change in healthy food provision and parenting practices for healthy food
- Improvement in diet composition.
- Improvement in knowledge of physical activity and nutrition.
- Improvement in cardio-metabolic variables (blood pressure, glucose, HbA1c, cholesterol)
The Investigators will also include qualitative data collected from:
- Evaluation forms following each intervention workshop session which will be completed by the Parent/guardian, child and facilitator
- Feedback from focus groups to be held following completion of the total intervention i.e. 8 sessions
To investigate whether the lifestyle programme results in changes to the following outcomes 3 and 6 months after baseline assessment (Parent(s)/guardian(s))
- An increase in objectively measured total volume of physical activity
- An increase in the proportion meeting MVPA guidelines (measured objectively)
- Reduction in time spent sedentary (measured objectively and self-reported)
- Change in self-reported physical activity
- Reduction in measures of adiposity (body mass index percentile, per cent body fat)
- Change in healthy food provision and parenting practices for healthy food
- Improvement in diet composition.
- Improvement in knowledge of physical activity and nutrition.
Type d'étude
Interventionnel
Inscription (Réel)
318
Phase
- N'est pas applicable
Contacts et emplacements
Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.
Lieux d'étude
-
-
-
Leicester, Royaume-Uni, LE4 5pW
- University Hospitals of Leicester
-
-
Critères de participation
Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.
Critère d'éligibilité
Âges éligibles pour étudier
12 ans à 14 ans (Enfant)
Accepte les volontaires sains
Non
Sexes éligibles pour l'étude
Tout
La description
Inclusion Criteria:
Parents/guardians will answer questions in the eligibility questionnaire about their child and family health history. Participants will be invited to participate if they are 12-14 years old inclusive (12 years 0 days to 14 years 354 days old) and are identified as having the following risk factors for development of Type 2 Diabetes (which will be identified from the eligibility questionnaire):
BMI > 95th percentile for age and gender OR
BMI > 85th percentile PLUS one other from the following list:
- Family history of Diabetes (first degree relative).
- Non-white ethnicity.
- Watching TV/play computer games for more than 2 hours a day (self-report).
- Sugar intake more than 1.5 cans (or 532 ml) of fizzy pop/fruit juice per day (self-report).
Exclusion Criteria:
Young people will not be eligible for participation in the study if they are outside the age range of interest (<11 years and 364 days or >14 years and 1 day), have an existing diagnosis of Type 1 or Type 2 Diabetes, < 85th percentile. Young people will also be excluded if they themselves do not provide written assent or their parent/guardian does not provide written consent.
Plan d'étude
Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: La prévention
- Répartition: Randomisé
- Modèle interventionnel: Affectation parallèle
- Masquage: Aucun (étiquette ouverte)
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
|
Aucune intervention: Control
The control participants will not receive the educational intervention but will be provided with a detailed advice leaflet for themselves and their parents/guardians.
|
|
|
Autre: Intervention
The educational intervention participants will receive the eight 90 minute sessions of an interactive family based lifestyle programme.
|
Participants will attend eight 90 minute sessions of an interactive lifestyle programme along with their parent(s)/guardian(s).
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
The primary endpoint is to detect a change in objectively measured MVPA of 10 minutes per day within the intervention group at 6 months.
Délai: 6 months post baseline
|
Participating children and adults will be asked to wear the wrist worn GENEActiv accelerometer (ActivInsights, Kimbolton, Cambridgeshire, UK) continuously for up to 8 days.
|
6 months post baseline
|
Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
An increase in total volume of physical activity
Délai: 3 and 6 months
|
Participating children and adults will be asked to wear the wrist worn GENEActiv accelerometer (ActivInsights, Kimbolton, Cambridgeshire, UK) continuously for up to 8 days.
|
3 and 6 months
|
|
An increase in the proportion meeting MVPA guidelines
Délai: 3 and 6 months
|
Participating children and adults will be asked to wear the wrist worn GENEActiv accelerometer (ActivInsights, Kimbolton, Cambridgeshire, UK) continuously for up to 8 days.
|
3 and 6 months
|
|
Reduction in time spent sedentary
Délai: 3 and 6 months
|
Participating children and adults will be asked to wear the wrist worn GENEActiv accelerometer (ActivInsights, Kimbolton, Cambridgeshire, UK) continuously for up to 8 days.
|
3 and 6 months
|
|
Change in physical activity levels
Délai: 3 and 6 months
|
Self reported - questionnaire
|
3 and 6 months
|
|
Reduction in Body mass index percentile (BMI)
Délai: 3 and 6 months
|
Body mass will be measured to the nearest 0.1kg and height will be measured to the nearest 0.1 cm using a clinically approved bioelectrical impedance scale and a portable stadiometer, respectively.
BMI will be calculated as weight/height2 and will be converted to a BMI percentile based on WHO growth charts
|
3 and 6 months
|
|
Change in healthy food provision and parenting practices for healthy food
Délai: 3 and 6 months
|
As parents are active participants in the intervention The Investigators will also query their knowledge and attitudes towards healthy eating and physical activity.
|
3 and 6 months
|
|
Improvement in diet composition
Délai: 3 and 6 months
|
The Investigators will query the nutrition habits of participants to investigate any changes in the behaviours targeted in the workshops.
A food frequency questionnaire (FFQ) taken from the ISCOLE study that was adapted from the HBSC Study will be used to query the consumption of 23 food categories in a "usual" week.
The Investigators will also query breakfast consumption for weekdays and weekends.
The Investigators have also created ad hoc questions on other intervention targets of snacking behaviours, fruit and vegetable intake and fizzy drink consumption.
This ad hoc method has been used in other international multi-site studies.
|
3 and 6 months
|
|
Improvement in knowledge of physical activity and nutrition
Délai: 3 and 6 months
|
The physical activity questionnaire for adolescents (PAQ-A) [62] will be used to assess the Types and context of physical activity in order to investigate changes in the Types of sports/exercise/activities the participating child may participate in (information which is not available from the accelerometer or the majority of other validated self-report questionnaires).
This questionnaire requests responses for the last 7 days by asking participants to check a list of activities for frequency of participation.
This questionnaire has received support from an expert panel and has also high validity against objective measures and moderate reliability.
|
3 and 6 months
|
|
Improvement in HbA1c
Délai: 3 and 6 months
|
Biochemical measures (Child only) - HbA1c
|
3 and 6 months
|
|
Improvement in Triglycerides
Délai: 3 and 6 months
|
Biochemical measures (Child only) - Triglycerides
|
3 and 6 months
|
|
Improvement in Glucose
Délai: 3 and 6 months
|
Biochemical measures (Child only) - Glucose
|
3 and 6 months
|
|
Improvement in HDL-C
Délai: 3 and 6 months
|
Biochemical measures (Child only) HDL-C
|
3 and 6 months
|
|
Improvement in Total Cholesterol
Délai: 3 and 6 months
|
Biochemical measures (Child only) -Total cholesterol will be measured using a point-of-care testing (POCT) and LDL-C will be calculated.
|
3 and 6 months
|
|
Improvement in cardio-metabolic variables
Délai: 3 and 6 months
|
Biochemical measures (Child only) - Capillary blood samples will be taken from each child using the finger prick method.
The CardioChek® system will be used as the POCT method.
The CardioChek® system is a portable hand held device that requires between 15 to 40 µL capillary sample from a finger-stick for each test.
The CardioChek® system is certified by the Cholesterol Reference Method Laboratory Network (CRMLN) and National Cholesterol Education Program (NCEP), is FDA-cleared, CE-marked, internationally registered, and is CLIA-waived by the Centers for Medicare & Medicaid Services, USA.
|
3 and 6 months
|
|
Blood Pressure (Child)
Délai: 3 and 6 months
|
Arterial blood pressure will be measured using an automated sphygmomanometer with an appropriate sized cuff while the patient is seated, and having rested quietly for 5 minutes.
Three measurements will be obtained for blood pressure and an average of the last two will be used in any analysis.
|
3 and 6 months
|
|
Blood Pressure (Parent(s)/guardian(s))
Délai: 3 and 6 months
|
Arterial blood pressure will be measured using an automated sphygmomanometer with an appropriate sized cuff while the patient is seated, and having rested quietly for 5 minutes.
Three measurements will be obtained for blood pressure and an average of the last two will be used in any analysis.
|
3 and 6 months
|
Collaborateurs et enquêteurs
C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.
Parrainer
Collaborateurs
Les enquêteurs
- Chercheur principal: Melanie J Davies, MD, University Hospitals, Leicester
Dates d'enregistrement des études
Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.
Dates principales de l'étude
Début de l'étude
1 juillet 2016
Achèvement primaire (Réel)
1 mars 2017
Achèvement de l'étude (Réel)
1 octobre 2017
Dates d'inscription aux études
Première soumission
5 mai 2016
Première soumission répondant aux critères de contrôle qualité
22 juillet 2016
Première publication (Estimation)
27 juillet 2016
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
16 janvier 2019
Dernière mise à jour soumise répondant aux critères de contrôle qualité
14 janvier 2019
Dernière vérification
1 janvier 2019
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- 65436
Plan pour les données individuelles des participants (IPD)
Prévoyez-vous de partager les données individuelles des participants (DPI) ?
Oui
Description du régime IPD
Non identifiable participant data will be only be shared with the study collaborators.
Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .