Breaking the Cycle: Real-Time Family Oral Microbial Transmission Patterns as Intervention Targets
This study aims to understand how oral bacteria that cause tooth decay and gum disease spread among family members and whether treating multiple family members can reduce the return of these bacteria after dental treatment.
Families with children aged 5-12 years will be recruited from university dental clinics. Participants will be assigned to one of three treatment groups: treatment for the child only, treatment for the child and parents, or treatment for all family members. Researchers will collect oral bacterial samples from family members before and after treatment and will monitor close-contact interactions within the household using wearable proximity-tracking devices.
The study will also collect information about oral health habits, family interactions, and environmental factors that may influence bacterial transmission. By combining bacterial DNA analysis with information about family contact patterns, researchers hope to better understand how oral bacteria are shared within households and whether family-based treatment approaches can reduce bacterial recolonization after dental therapy.
The results of this study may help improve strategies for preventing childhood tooth decay and gum disease by addressing family-level sources of bacterial transmission.
Aperçu de l'étude
Statut
Les conditions
Intervention / Traitement
Description détaillée
Oral diseases, including dental caries and periodontal diseases, are among the most prevalent chronic diseases worldwide. Although oral pathogens are known to be transmissible, the mechanisms by which disease-associated bacteria spread within families and contribute to recolonization after treatment remain poorly understood.
This randomized clinical trial will investigate familial oral microbial transmission and the role of household-level interventions in modifying microbial recolonization following professional dental therapy. Forty-five families will be recruited from university dental clinics and randomized into one of three intervention groups: (A) child-only plaque disruption, (B) child plus parent plaque disruption, or (C) plaque disruption for all family members. Eligible households must include at least two children aged 5-12 years and at least one adult requiring periodontal therapy or a child at high risk of disease recurrence.
Oral microbial samples will be collected from all participating family members at multiple oral sites, including saliva, buccal mucosa, tongue, supragingival plaque, and subgingival plaque. Follow-up sampling will occur at 1 week, 4-6 weeks, and 3 months after treatment. Participants will complete oral health and demographic questionnaires, and all family members will wear Ultrawide Band (UWB) proximity-tracking devices to quantify real-time interpersonal contact patterns within the household. Airborne microbial sampling will also be performed to investigate potential aerosol-mediated transmission pathways.
Bacterial DNA sequencing, source-tracking algorithms, and quantitative PCR analyses will be used to identify sources of microbial recolonization and quantify transmission among family members. Generalized Linear Mixed Models will be used to examine associations between microbial transmission, proximity measures, demographic variables, and household characteristics.
The primary objective is to determine whether reducing familial pathogen burden through household-level treatment decreases recolonization of oral pathogens following dental therapy. Secondary objectives include characterizing contact-dependent and airborne transmission pathways and identifying factors associated with oral microbial transmission within families.
Type d'étude
Inscription (Estimé)
Phase
- N'est pas applicable
Contacts et emplacements
Coordonnées de l'étude
- Nom: Khaled Altabtbaei, BDM, PhD
- Numéro de téléphone: 780-777-2456
- E-mail: altabtba@ualberta.ca
Lieux d'étude
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Alberta
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Edmonton, Alberta, Canada, T6G2L7
- Kaye Edmonton Clinic - University of Alberta School of Dentistry
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Contact:
- Khaled Altabtbaei, BDM, PhD
- Numéro de téléphone: 780-777-2456
- E-mail: altabtba@ualberta.ca
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-
Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
- Enfant
Accepte les volontaires sains
La description
Inclusion Criteria:
- Families with at least two children aged 5-12 years living in the same household.
- least one parent or guardian diagnosed with Stage II or III periodontitis requiring non-surgical periodontal therapy.
- At least one child who has undergone caries treatment and is considered at high risk for disease recurrence.
- Willingness of all participating household members to provide oral samples and participate in study procedures.
- Ability of participants or their legal guardians to provide informed consent, and assent from children where applicable.
Exclusion Criteria:
- Children living in multiple households or shared-custody arrangements during the study period.
- Households unable to complete study visits or follow-up procedures.
- Individuals unwilling or unable to comply with study procedures.
- Individuals who do not provide informed consent or assent, where applicable.
- Medical or behavioral conditions that, in the opinion of the investigators, would preclude safe participation in the study.
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: La prévention
- Répartition: Randomisé
- Modèle interventionnel: Affectation parallèle
- Masquage: Aucun (étiquette ouverte)
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
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Expérimental: Child-Only Treatment
The primary child participant receives professional dental plaque disruption and oral hygiene intervention.
Other household members do not receive study-related treatment.
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Professional dental plaque disruption and oral hygiene treatment performed to reduce oral bacterial burden.
The intervention may include professional dental cleaning, plaque removal, and periodontal therapy as clinically indicated according to study group assignment.
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Expérimental: Child Plus Parents Treatment
The primary child participant and both parents receive professional dental plaque disruption and oral hygiene intervention
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Professional dental plaque disruption and oral hygiene treatment performed to reduce oral bacterial burden.
The intervention may include professional dental cleaning, plaque removal, and periodontal therapy as clinically indicated according to study group assignment.
|
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Expérimental: Whole-Family Treatment
All participating household members receive professional dental plaque disruption and oral hygiene intervention using a family-wide treatment approach.
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Professional dental plaque disruption and oral hygiene treatment performed to reduce oral bacterial burden.
The intervention may include professional dental cleaning, plaque removal, and periodontal therapy as clinically indicated according to study group assignment.
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Proportional Contribution of Familial Sources to Oral Microbial Recolonization
Délai: 3 Months
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Percentage contribution (%) of each household member to the primary child's post-treatment oral microbial recolonization, estimated using bacterial DNA sequencing and Bayesian microbial source-tracking (STENSL).
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3 Months
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Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
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Oral Microbial Community Reconstitution
Délai: Baseline to 3 Months
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Oral microbial community reconstitution assessed by relative abundance (%) of oral bacterial taxa and microbial alpha diversity of the oral microbiota, measured using 16S rRNA gene sequencing.
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Baseline to 3 Months
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Frequency of Close-Contact Interactions Measured using Ultrawide Band (UWB)
Délai: 1 Week
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Number of close-contact interactions (count) between household members measured using wearable Ultrawide Band (UWB) proximity sensors.
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1 Week
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Correlation Between Close-Contact Duration and Familial Contribution to Oral Microbial Recolonization
Délai: Baseline to 3 Months
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Correlation between cumulative close-contact duration (minutes), measured using wearable Ultrawide Band (UWB) proximity sensors, and the proportional contribution (%) of each family member to the primary child's oral microbial recolonization, estimated from bacterial DNA sequencing data using the Bayesian microbial source-tracking algorithm (STENSL).
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Baseline to 3 Months
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Collaborateurs et enquêteurs
Parrainer
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude (Estimé)
Achèvement primaire (Estimé)
Achèvement de l'étude (Estimé)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Réel)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Mots clés
- Santé bucco-dentaire
- Maladie parodontale
- Microbiote oral
- Intervention basée sur la famille
- Santé bucco-dentaire pédiatrique
- family microbial transmission
- Plaque recolonization
- Real-time proximity tracking
- Ultrawide Band (UWB)
- Oral bacterial transmission
- Intergenerational pathogen transfer
- Biofilm disruption
- Microbial source tracking
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- Pro00164902
Plan pour les données individuelles des participants (IPD)
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Description du régime IPD
Informations sur les médicaments et les dispositifs, documents d'étude
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