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- Essai clinique NCT07675746
A Study to Evaluate the Safety and Pharmacokinetics of RC001 in Children With Dravet Syndrome
23 juin 2026 mis à jour par: Second Affiliated Hospital of Guangzhou Medical University
An Investigator-Initiated Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RC001 in Patients With Dravet Syndrome Aged 2 to 18 Years
This is an open-label, single-center study to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of intrathecal RC001 in patients with Dravet syndrome aged 2 to 18 years.
The study includes a dose-escalation part followed by a fixed dose treatment part, with participant progression based on investigator-assessed safety and efficacy.
Aperçu de l'étude
Statut
Recrutement
Les conditions
Intervention / Traitement
Description détaillée
This is an open-label, single-center clinical study designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of RC001 administered intrathecally in patients aged 2 to 18 years with Dravet syndrome.
The study consists of two stages: Stage 1 (intra-subject dose escalation) and Stage 2 (fixed-dose multiple dosing).
In Stage 1, three cohorts will be enrolled with a total of three participants.
In Stage 2, a total of five participants will be enrolled to receive fixed-dose multiple administrations.
Participants in both the dose-escalation stage and the fixed-dose multiple dosing stage may enter an extension phase after completion of the last dose, based on the investigator's assessment of efficacy and safety.
Type d'étude
Interventionnel
Inscription (Estimé)
8
Phase
- Première phase 1
Contacts et emplacements
Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.
Coordonnées de l'étude
- Nom: Weiping Liao, Ph.D
- Numéro de téléphone: 086-020-34152498
- E-mail: wpliao@163.net
Lieux d'étude
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Guangdong
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Guangzhou, Guangdong, Chine, 510120
- Recrutement
- The second Affiliated Hospital of Guangzhou Medical University
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Contact:
- Juan Chen
- Numéro de téléphone: 086-020-34153599
- E-mail: gyeylcyjzx@163.com
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Critères de participation
Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.
Critère d'éligibilité
Âges éligibles pour étudier
- Enfant
- Adulte
Accepte les volontaires sains
Non
La description
Inclusion Criteria:
- Patients aged 2-18 years with Dravet syndrome caused by SCN1A mutations, with onset before 12 months of age characterized by focal seizures, hemiclonic seizures, generalized tonic-clonic seizures, or myoclonic seizures, and with MRI excluding progressive neurological disease either historically or at screening. Enrolled participants will be assigned as follows: 1 participant aged 13-18 years, 1 aged 7-12 years, and 1 aged 2-6 years will undergo intra-subject dose escalation; 5 participants aged 2-12 years will receive fixed-dose multiple administrations.
- Seizure frequency requirements: at least 6 cumulative seizures within 12 weeks prior to the day of signing the ICF, and at least 2 seizures within 4 weeks prior to ICF signing. For participants in Stage 2 (fixed-dose multiple administration), seizure frequency must also be ≥4 within 4 weeks after ICF signing.
- Documented pathogenic or likely pathogenic variants in the SCN1A gene associated with Dravet syndrome.
- Prior treatment with at least one anti-epileptic intervention, including anti-seizure medications (ASM), ketogenic diet, or vagus nerve stimulation (VNS), with inadequate seizure control or discontinuation due to adverse events (AEs).
- Use of at least one ASM prior to screening, with a stable dose for at least 4 weeks before screening.
- All epilepsy-related treatments, including ASM and other interventions (ketogenic diet and VNS), must be stable for at least 4 weeks prior to screening and are expected to remain stable throughout the study (medications adjusted by body weight are allowed).
- Willingness to participate and provision of written informed consent.
Exclusion Criteria:
- Presence of other known pathogenic gene mutations causing Dravet syndrome, or SCN1A gain-of-function mutations reported in the literature and/or experimentally validated, including but not limited to: Ala23Glu, Thr162Ile, Thr226Met, Ser228Pro, Val229Leu, Ile236Val, Ile236Thr, Val250Leu, Leu263Val, Thr398Met, Ala420Val, Val422Leu, Ile883Thr, Leu893Phe, Ala989Thr, Thr1174Ser, Trp1204Arg, Ala1339Asp, Pro1345Ser, Pro1345Leu, Ser1346Pro, Ile1347Val, Val1481Ile, Ile1483Met, Gln1489Lys, Ile1498Thr, Ile1498Met, Phe1499Leu, Met1500Val, Arg1575Cys, Val1611Phe, Leu1624Pro, Arg1636Gln, Arg1648Cys, Leu1649Gln, Leu1660Ile, Phe1661Leu, Ala1669Glu, Leu1670Trp, Gly1674Arg, Phe1774Ser, Asp1866Tyr.
- Current maintenance treatment with anti-epileptic drugs primarily acting as sodium channel blockers, including but not limited to carbamazepine, oxcarbazepine, lamotrigine, lacosamide, or rufinamide.
- Ongoing neuromodulation therapy (e.g., responsive neurostimulation or deep brain stimulation), excluding vagus nerve stimulation (VNS).
- Receipt of gene therapy or cell therapy within 1 year prior to screening.
- Receipt of any vaccination within 12 weeks prior to screening.
- Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >2× the upper limit of normal (ULN), or total bilirubin >1.5× ULN; renal insufficiency or serum creatinine >1.2× ULN.
- Presence of any severe uncontrolled disease other than Dravet syndrome.
- History of autoimmune disease, or uncontrolled infectious disease within 1 week prior to screening.
- History of brain or spinal cord disease (other than epilepsy, Dravet syndrome, or trauma), or history of bacterial meningitis.
- Spinal deformity or other conditions that may interfere with normal cerebrospinal fluid (CSF) flow, or implantation of a CSF shunt.
- Pregnant or breastfeeding females.
- Any other significant disease or condition that, in the investigator's judgment, may pose a risk to the patient, interfere with study results, or affect the patient's ability to participate in the study.
Plan d'étude
Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Traitement
- Répartition: Non randomisé
- Modèle interventionnel: Affectation à un seul groupe
- Masquage: Aucun (étiquette ouverte)
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
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Expérimental: Dose Escalation Cohort
Participants will receive RC001 in a dose-escalation manner to evaluate the safety, tolerability, and preliminary pharmacodynamic effects.
Dose levels will be administered sequentially, and escalation decisions will be based on safety data from previously treated participants.
This cohort includes 3 participants.
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RC001 will be administered using a sequential dose-escalation scheme.
Participants will receive ascending dose levels of RC001 according to the study protocol.
Dose escalation will proceed only after safety data from prior participants have been reviewed and deemed acceptable.
This intervention is intended to evaluate safety, tolerability, and preliminary pharmacodynamic effects at increasing dose levels.
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Expérimental: Fixed Dose Cohort
Participants will receive a predefined fixed dose of RC001 selected based on safety, tolerability, and pharmacological data obtained from the dose-escalation cohort.
This cohort is designed to further evaluate safety and preliminary efficacy at the selected dose level.
This cohort includes 5 participants.
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RC001 will be administered at a predefined fixed dose level selected based on safety, tolerability, and pharmacological data obtained from the dose-escalation cohort.
This intervention is intended to further evaluate safety and preliminary efficacy at the selected dose level in a fixed-dose setting.
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Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
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Number of Participants With Treatment-Emergent Adverse Events (TEAEs)
Délai: From first dose to 24 weeks after the last dose
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A treatment-emergent adverse event is defined as any adverse event that occurs or worsens after the first dose of RC001 through the end of follow-up.
TEAEs will be summarized by system organ class, preferred term, severity, seriousness, and relationship to study drug or study procedure.
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From first dose to 24 weeks after the last dose
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Number of Participants With Serious Adverse Events (SAEs)
Délai: From signing informed consent to 24 weeks after the last dose
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Serious adverse events will be collected and summarized throughout the study.
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From signing informed consent to 24 weeks after the last dose
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Number of Participants With Clinically Significant Abnormalities in Vital Signs
Délai: From baseline to 24 weeks after the last dose
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Vital signs include body temperature, heart rate, respiratory rate, systolic blood pressure, and diastolic blood pressure.
Clinically significant abnormalities will be determined by the investigator.
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From baseline to 24 weeks after the last dose
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Number of Participants With Clinically Significant Abnormal Physical Examination Findings
Délai: From baseline to 24 weeks after the last dose
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Physical examination findings will be assessed for clinically significant abnormalities as determined by the investigator.
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From baseline to 24 weeks after the last dose
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Number of Participants With Clinically Significant Abnormal Laboratory Test Results
Délai: From baseline to 24 weeks after the last dose
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Laboratory assessments may include hematology, serum chemistry, coagulation, urinalysis, and cerebrospinal fluid laboratory tests, as applicable.
Clinically significant abnormalities will be determined by the investigator.
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From baseline to 24 weeks after the last dose
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Number of Participants With Clinically Significant Abnormal 12-Lead Electrocardiogram (ECG) Findings
Délai: From baseline to 24 weeks after the last dose
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ECG parameters may include heart rate, PR interval, QRS duration, QT interval, and corrected QT interval.
Clinically significant abnormalities will be determined by the investigator.
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From baseline to 24 weeks after the last dose
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Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
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Maximum Observed Plasma Concentration (Cmax) of RC001
Délai: From first dose to last dose up to 12 weeks
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Cmax of RC001 in plasma following intrathecal administration.
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From first dose to last dose up to 12 weeks
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Time to Maximum Observed Plasma Concentration (Tmax) of RC001
Délai: From first dose through 12 weeks
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Tmax of RC001 in plasma following intrathecal administration.
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From first dose through 12 weeks
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Trough Concentration (Ctrough) of RC001 in Cerebrospinal Fluid
Délai: Prior to each dose through 12 weeks
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Trough concentration of RC001 in cerebrospinal fluid before each intrathecal dose.
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Prior to each dose through 12 weeks
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Percentage Change From Baseline in Countable Seizure Frequency at 12 Weeks After the Last Dose
Délai: Baseline and the 28-day period preceding 12 weeks after the last dose
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Countable seizure frequency will be calculated as the number of countable seizures during the 28-day period preceding 12 weeks after the last dose of RC001.Baseline countable seizure frequency is defined as the number of countable seizures during baseline observation period.
Percentage change from baseline will be calculated as: (post-baseline 28-day seizure frequency - baseline 28-day seizure frequency) / baseline 28-day seizure frequency x 100%.
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Baseline and the 28-day period preceding 12 weeks after the last dose
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Percentage Change From Baseline in Countable Seizure Frequency at 24 Weeks After the Last Dose
Délai: Baseline and the 28-day period preceding 24 weeks after the last dose
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Countable seizure frequency will be calculated as the number of countable seizures during the 28-day period preceding 24 weeks after the last dose of RC001.
Baseline countable seizure frequency is defined as the number of countable seizures during baseline observation period.
Percentage change from baseline will be calculated as: (post-baseline 28-day seizure frequency - baseline 28-day seizure frequency) / baseline 28-day seizure frequency x 100%.
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Baseline and the 28-day period preceding 24 weeks after the last dose
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Clinical Global Impression of Change (CGI-C) Score at 24 Weeks After the Last Dose
Délai: 24 weeks after the last dose
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The Clinical Global Impression of Change (CGI-C) is a clinician-rated 7-point scale assessing overall clinical change relative to baseline.
Scores range from 1 to 7: 1 = very much improved, 2 = much improved, 3 = minimally improved, 4 = no change, 5 = minimally worse, 6 = much worse, and 7 = very much worse.
Lower scores indicate greater improvement.
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24 weeks after the last dose
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Caregiver Global Impression of Change (CaGI-C) Score at 24 Weeks After the Last Dose
Délai: 24 weeks after the last dose
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The Caregiver Global Impression of Change (CaGI-C) is a caregiver-rated 7-point scale assessing overall clinical change relative to baseline.
Scores range from 1 to 7: 1 = very much improved, 2 = much improved, 3 = minimally improved, 4 = no change, 5 = minimally worse, 6 = much worse, and 7 = very much worse.
Lower scores indicate greater improvement.
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24 weeks after the last dose
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Change From Baseline in Vineland Adaptive Behavior Scales, Third Edition (Vineland-3) Expressive Communication Raw Score at 24 Weeks After the Last Dose
Délai: Baseline and 24 weeks after the last dose
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The Vineland Adaptive Behavior Scales, Third Edition (Vineland-3) measures adaptive behavior.
The Expressive Communication subdomain raw score will be assessed.
Raw scores have a minimum value of 0, and the maximum value varies by subdomain according to the Vineland-3 scoring manual.
Higher scores indicate better adaptive functioning.
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Baseline and 24 weeks after the last dose
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Change From Baseline in Vineland Adaptive Behavior Scales, Third Edition (Vineland-3) Receptive Communication Raw Score at 24 Weeks After the Last Dose
Délai: Baseline and 24 weeks after the last dose
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The Vineland Adaptive Behavior Scales, Third Edition (Vineland-3) measures adaptive behavior.
The Receptive Communication subdomain raw score will be assessed.
Raw scores have a minimum value of 0, and the maximum value varies by subdomain according to the Vineland-3 scoring manual.
Higher scores indicate better adaptive functioning.
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Baseline and 24 weeks after the last dose
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Change From Baseline in Age-Appropriate Wechsler Intelligence Scale Score at 24 Weeks After the Last Dose
Délai: Baseline and 24 weeks after the last dose
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Cognitive function will be assessed using an age-appropriate Wechsler intelligence scale.
The selected composite or total score will be analyzed as the change from baseline.
Higher scores indicate better cognitive functioning.
The applicable scale version and score range will be defined according to the participant's age and the study assessment manual.
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Baseline and 24 weeks after the last dose
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Collaborateurs et enquêteurs
C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.
Collaborateurs
Dates d'enregistrement des études
Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.
Dates principales de l'étude
Début de l'étude (Réel)
22 décembre 2025
Achèvement primaire (Estimé)
31 décembre 2027
Achèvement de l'étude (Estimé)
31 décembre 2027
Dates d'inscription aux études
Première soumission
16 juin 2026
Première soumission répondant aux critères de contrôle qualité
23 juin 2026
Première publication (Réel)
30 juin 2026
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
30 juin 2026
Dernière mise à jour soumise répondant aux critères de contrôle qualité
23 juin 2026
Dernière vérification
1 décembre 2025
Plus d'information
Termes liés à cette étude
Mots clés
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- 2025-LCYJ-187
Plan pour les données individuelles des participants (IPD)
Prévoyez-vous de partager les données individuelles des participants (DPI) ?
NON
Description du régime IPD
Individual participant data (IPD) from this early-phase study will not be shared due to the sensitive nature of patient data and the need to protect participant privacy.
Informations sur les médicaments et les dispositifs, documents d'étude
Étudie un produit pharmaceutique réglementé par la FDA américaine
Non
Étudie un produit d'appareil réglementé par la FDA américaine
Non
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