Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom
A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Cancer in East Anglia, Trent and West Midlands
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between genes and the environment in patients with cancer in East Anglia, Trent, or West Midlands of the United Kingdom.
調査の概要
状態
詳細な説明
OBJECTIVES:
- To obtain epidemiological information and biological material on a population-based series of cancer cases, including malignant melanoma, lymphoma, bladder, kidney, esophageal, and pancreatic cancer, and brain tumors.
- Identify novel cancer susceptibility genes, by comparison of genotype frequencies in cases with the corresponding frequencies in large control series.
- To estimate the age and sex-specific risks associated with variants in predisposition genes.
- To evaluate interactions between polymorphisms in predisposition genes and potential lifestyle risk factors.
OUTLINE: This is a multicenter study.
Patients complete a detailed epidemiological questionnaire that includes information on education, occupation, smoking habits, alcohol consumption, height, weight, reproductive history (age at menarche, age at pregnancies, parity, and age at menopause), oral contraceptive use, hormone replacement therapy use, family history of cancer, and past medical history.
Blood samples are collected from patients. DNA is extracted from these blood samples, from samples collected from cancer-free control participants in MREC-SEARCH-CONTROL, and from additional controls through the European Prospective Investigation of Cancer (EPIC) study (a population-based study of diet and health based in Norfolk, East Anglia). DNA samples are analyzed for polymorphisms of low penetrance cancer susceptibility genes.
In addition to the cancer patients recruited for this study, patients with breast, ovarian, endometrial, colorectal, and prostate cancer are recruited for the following related clinical trials: MREC-SEARCH-BREAST, MREC-SEARCH-OVARIAN, MREC-SEARCH-ENDOMETRIAL, MREC-SEARCH-COLORECTAL, and MREC-SEARCH-PROSTATE.
研究の種類
入学 (予想される)
連絡先と場所
研究場所
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England
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Cambridge、England、イギリス、CB1 8RN
- 募集
- University of Cambridge Cancer Research UK
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コンタクト:
- Contact Person
- 電話番号:44-122-374-0166
- メール:paul.pharoah@srl.cam.ac.uk
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
DISEASE CHARACTERISTICS:
- Diagnosed with bladder cancer, kidney cancer, esophageal cancer, pancreatic cancer, brain cancer, malignant melanoma, or lymphoma within the past 5 years
Identified through the Cancer Research Network OR through the cancer registry serving any of the following geographic regions of the United Kingdom:
- East Anglia
- West Midlands
- Trent
PATIENT CHARACTERISTICS:
- Identified by the patient's general practitioner as fit to contact for this study
- No serious mental illness or retardation
PRIOR CONCURRENT THERAPY:
- Not specified
研究計画
研究はどのように設計されていますか?
この研究は何を測定していますか?
主要な結果の測定
結果測定 |
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疫学的情報と生物学的資料の取得
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新規がん感受性遺伝子の同定
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素因遺伝子のバリアントに関連する年齢および性別固有のリスクの推定
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Evaluation of interactions between polymorphisms in predisposition genes and potential lifestyle risk factors
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協力者と研究者
スポンサー
捜査官
- スタディチェア:Paul Pharoah, MD、Cancer Research UK
研究記録日
主要日程の研究
研究開始
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
キーワード
- 食道がん
- 膀胱がん
- 膵臓癌
- 成人脳幹グリオーマ
- 成人脈絡叢腫瘍
- 成人頭蓋咽頭腫
- メラノーマ
- 腎細胞がん
- 眼内黒色腫
- 原発性中枢神経系非ホジキンリンパ腫
- 眼内リンパ腫
- 成人星状細胞腫瘍
- 成人松果体実質腫瘍
- 腎明細胞肉腫
- 腎臓のラブドイド腫瘍
- 非皮膚節外性リンパ腫
- 原発性中枢神経系ホジキンリンパ腫
- 成人ホジキンリンパ腫
- 成人T細胞白血病/リンパ腫
- 皮膚リンパ腫
- 成人非ホジキンリンパ腫
- 先天性間葉芽腎腫
- 腎臓の末梢原始神経外胚葉性腫瘍
- エイズ関連リンパ腫
- 成人脳腫瘍
- adult ependymal tumors
- adult meningeal tumor
- adult oligodendroglial tumors
- adult embryonal tumor
- transitional cell cancer of the renal pelvis and ureter
追加の関連 MeSH 用語
その他の研究ID番号
- CDR0000598879
- MREC-07/MRE05/17
- MREC-SEARCH-CANCER
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
多型分析の臨床試験
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Hvidovre University HospitalElsassFonden終了しました