- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT00757614
Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom
A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Cancer in East Anglia, Trent and West Midlands
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between genes and the environment in patients with cancer in East Anglia, Trent, or West Midlands of the United Kingdom.
Studieoversigt
Status
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
OBJECTIVES:
- To obtain epidemiological information and biological material on a population-based series of cancer cases, including malignant melanoma, lymphoma, bladder, kidney, esophageal, and pancreatic cancer, and brain tumors.
- Identify novel cancer susceptibility genes, by comparison of genotype frequencies in cases with the corresponding frequencies in large control series.
- To estimate the age and sex-specific risks associated with variants in predisposition genes.
- To evaluate interactions between polymorphisms in predisposition genes and potential lifestyle risk factors.
OUTLINE: This is a multicenter study.
Patients complete a detailed epidemiological questionnaire that includes information on education, occupation, smoking habits, alcohol consumption, height, weight, reproductive history (age at menarche, age at pregnancies, parity, and age at menopause), oral contraceptive use, hormone replacement therapy use, family history of cancer, and past medical history.
Blood samples are collected from patients. DNA is extracted from these blood samples, from samples collected from cancer-free control participants in MREC-SEARCH-CONTROL, and from additional controls through the European Prospective Investigation of Cancer (EPIC) study (a population-based study of diet and health based in Norfolk, East Anglia). DNA samples are analyzed for polymorphisms of low penetrance cancer susceptibility genes.
In addition to the cancer patients recruited for this study, patients with breast, ovarian, endometrial, colorectal, and prostate cancer are recruited for the following related clinical trials: MREC-SEARCH-BREAST, MREC-SEARCH-OVARIAN, MREC-SEARCH-ENDOMETRIAL, MREC-SEARCH-COLORECTAL, and MREC-SEARCH-PROSTATE.
Undersøgelsestype
Tilmelding (Forventet)
Kontakter og lokationer
Studiesteder
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England
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Cambridge, England, Det Forenede Kongerige, CB1 8RN
- Rekruttering
- University of Cambridge Cancer Research UK
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Kontakt:
- Contact Person
- Telefonnummer: 44-122-374-0166
- E-mail: paul.pharoah@srl.cam.ac.uk
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-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
DISEASE CHARACTERISTICS:
- Diagnosed with bladder cancer, kidney cancer, esophageal cancer, pancreatic cancer, brain cancer, malignant melanoma, or lymphoma within the past 5 years
Identified through the Cancer Research Network OR through the cancer registry serving any of the following geographic regions of the United Kingdom:
- East Anglia
- West Midlands
- Trent
PATIENT CHARACTERISTICS:
- Identified by the patient's general practitioner as fit to contact for this study
- No serious mental illness or retardation
PRIOR CONCURRENT THERAPY:
- Not specified
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
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Indhentning af epidemiologisk information og biologisk materiale
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Identifikation af nye kræftmodtagelighedsgener
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Estimering af alders- og kønsspecifikke risici forbundet med varianter i prædisponeringsgener
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Evaluation of interactions between polymorphisms in predisposition genes and potential lifestyle risk factors
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Samarbejdspartnere og efterforskere
Sponsor
Efterforskere
- Studiestol: Paul Pharoah, MD, Cancer Research UK
Datoer for undersøgelser
Studer store datoer
Studiestart
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
- kræft i spiserøret
- blærekræft
- kræft i bugspytkirtlen
- voksen hjernestammegliom
- voksen choroid plexus tumor
- voksen kraniopharyngiom
- melanom
- nyrecellekarcinom
- intraokulært melanom
- primært non-Hodgkin lymfom i centralnervesystemet
- intraokulært lymfom
- voksne astrocytiske tumorer
- voksen pineal parenkymal tumor
- klarcellet sarkom i nyren
- rhabdoid tumor i nyren
- ikke-kutan ekstranodal lymfom
- primært centralnervesystem Hodgkin lymfom
- voksen Hodgkin lymfom
- voksen T-celle leukæmi/lymfom
- kutant lymfom
- non-Hodgkin lymfom hos voksne
- medfødt mesoblastisk nefrom
- perifer primitiv neuroektodermal tumor i nyren
- AIDS-relateret lymfom
- voksen hjernetumor
- adult ependymal tumors
- adult meningeal tumor
- adult oligodendroglial tumors
- adult embryonal tumor
- transitional cell cancer of the renal pelvis and ureter
Yderligere relevante MeSH-vilkår
- Sygdomme i fordøjelsessystemet
- Sygdomme i nervesystemet
- Sygdomme i immunsystemet
- Neoplasmer efter histologisk type
- Neoplasmer
- Lymfoproliferative lidelser
- Lymfesygdomme
- Immunproliferative lidelser
- Urologiske neoplasmer
- Urogenitale neoplasmer
- Neoplasmer efter sted
- Nyresygdomme
- Urologiske sygdomme
- Karcinom
- Neoplasmer, kirtel og epitel
- Urinblæresygdomme
- Sygdomme i det endokrine system
- Gastrointestinale neoplasmer
- Neoplasmer i fordøjelsessystemet
- Gastrointestinale sygdomme
- Neoplasmer i endokrine kirtler
- Neoplasmer i hoved og hals
- Neuroektodermale tumorer
- Neoplasmer, kimceller og embryonale
- Neoplasmer, nervevæv
- Esophageale sygdomme
- Pancreassygdomme
- Neuroendokrine tumorer
- Nevi og melanomer
- Ureterale sygdomme
- Lymfom
- Nyre-neoplasmer
- Urinblære neoplasmer
- Bugspytkirtel neoplasmer
- Melanom
- Neoplasmer i nervesystemet
- Neoplasmer i centralnervesystemet
- Esophageale neoplasmer
- Carcinom, overgangscelle
- Ureterale neoplasmer
Andre undersøgelses-id-numre
- CDR0000598879
- MREC-07/MRE05/17
- MREC-SEARCH-CANCER
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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