- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00757614
Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom
A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Cancer in East Anglia, Trent and West Midlands
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between genes and the environment in patients with cancer in East Anglia, Trent, or West Midlands of the United Kingdom.
Study Overview
Status
Conditions
Detailed Description
OBJECTIVES:
- To obtain epidemiological information and biological material on a population-based series of cancer cases, including malignant melanoma, lymphoma, bladder, kidney, esophageal, and pancreatic cancer, and brain tumors.
- Identify novel cancer susceptibility genes, by comparison of genotype frequencies in cases with the corresponding frequencies in large control series.
- To estimate the age and sex-specific risks associated with variants in predisposition genes.
- To evaluate interactions between polymorphisms in predisposition genes and potential lifestyle risk factors.
OUTLINE: This is a multicenter study.
Patients complete a detailed epidemiological questionnaire that includes information on education, occupation, smoking habits, alcohol consumption, height, weight, reproductive history (age at menarche, age at pregnancies, parity, and age at menopause), oral contraceptive use, hormone replacement therapy use, family history of cancer, and past medical history.
Blood samples are collected from patients. DNA is extracted from these blood samples, from samples collected from cancer-free control participants in MREC-SEARCH-CONTROL, and from additional controls through the European Prospective Investigation of Cancer (EPIC) study (a population-based study of diet and health based in Norfolk, East Anglia). DNA samples are analyzed for polymorphisms of low penetrance cancer susceptibility genes.
In addition to the cancer patients recruited for this study, patients with breast, ovarian, endometrial, colorectal, and prostate cancer are recruited for the following related clinical trials: MREC-SEARCH-BREAST, MREC-SEARCH-OVARIAN, MREC-SEARCH-ENDOMETRIAL, MREC-SEARCH-COLORECTAL, and MREC-SEARCH-PROSTATE.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Locations
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England
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Cambridge, England, United Kingdom, CB1 8RN
- Recruiting
- University of Cambridge Cancer Research UK
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Contact:
- Contact Person
- Phone Number: 44-122-374-0166
- Email: paul.pharoah@srl.cam.ac.uk
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
DISEASE CHARACTERISTICS:
- Diagnosed with bladder cancer, kidney cancer, esophageal cancer, pancreatic cancer, brain cancer, malignant melanoma, or lymphoma within the past 5 years
Identified through the Cancer Research Network OR through the cancer registry serving any of the following geographic regions of the United Kingdom:
- East Anglia
- West Midlands
- Trent
PATIENT CHARACTERISTICS:
- Identified by the patient's general practitioner as fit to contact for this study
- No serious mental illness or retardation
PRIOR CONCURRENT THERAPY:
- Not specified
Study Plan
How is the study designed?
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
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Acquisition of epidemiological information and biological material
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Identification of novel cancer susceptibility genes
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Estimation of the age and sex-specific risks associated with variants in predisposition genes
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Evaluation of interactions between polymorphisms in predisposition genes and potential lifestyle risk factors
|
Collaborators and Investigators
Sponsor
Investigators
- Study Chair: Paul Pharoah, MD, Cancer Research UK
Study record dates
Study Major Dates
Study Start
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
- esophageal cancer
- bladder cancer
- pancreatic cancer
- adult brain stem glioma
- adult choroid plexus tumor
- adult craniopharyngioma
- melanoma
- renal cell carcinoma
- intraocular melanoma
- primary central nervous system non-Hodgkin lymphoma
- intraocular lymphoma
- adult astrocytic tumors
- adult pineal parenchymal tumor
- clear cell sarcoma of the kidney
- rhabdoid tumor of the kidney
- noncutaneous extranodal lymphoma
- primary central nervous system Hodgkin lymphoma
- adult Hodgkin lymphoma
- adult T-cell leukemia/lymphoma
- cutaneous lymphoma
- adult non-Hodgkin lymphoma
- congenital mesoblastic nephroma
- peripheral primitive neuroectodermal tumor of the kidney
- AIDS-related lymphoma
- adult brain tumor
- adult ependymal tumors
- adult meningeal tumor
- adult oligodendroglial tumors
- adult embryonal tumor
- transitional cell cancer of the renal pelvis and ureter
Additional Relevant MeSH Terms
- Digestive System Diseases
- Nervous System Diseases
- Immune System Diseases
- Neoplasms by Histologic Type
- Neoplasms
- Lymphoproliferative Disorders
- Lymphatic Diseases
- Immunoproliferative Disorders
- Urologic Neoplasms
- Urogenital Neoplasms
- Neoplasms by Site
- Kidney Diseases
- Urologic Diseases
- Carcinoma
- Neoplasms, Glandular and Epithelial
- Urinary Bladder Diseases
- Endocrine System Diseases
- Gastrointestinal Neoplasms
- Digestive System Neoplasms
- Gastrointestinal Diseases
- Endocrine Gland Neoplasms
- Head and Neck Neoplasms
- Neuroectodermal Tumors
- Neoplasms, Germ Cell and Embryonal
- Neoplasms, Nerve Tissue
- Esophageal Diseases
- Pancreatic Diseases
- Neuroendocrine Tumors
- Nevi and Melanomas
- Ureteral Diseases
- Lymphoma
- Kidney Neoplasms
- Urinary Bladder Neoplasms
- Pancreatic Neoplasms
- Melanoma
- Nervous System Neoplasms
- Central Nervous System Neoplasms
- Esophageal Neoplasms
- Carcinoma, Transitional Cell
- Ureteral Neoplasms
Other Study ID Numbers
- CDR0000598879
- MREC-07/MRE05/17
- MREC-SEARCH-CANCER
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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