Examining the Effects of Video-game Exercise on Mobility and Brain Plasticity in Individuals With Multiple Sclerosis
Examining the Effects of Dance, Dance Revolution on Mobility, Brain Plasticity and Cognition in Individuals With Multiple Sclerosis
調査の概要
詳細な説明
Dance Dance Revolution (DDR) may offer an innovative and highly effective format for delivering exercise programs to people with MS. It is a fun, engaging and interactive video game that requires players to move their feet to targets while matching the rhythm of a song. In addition, DDR, involving both aerobic exercise and cognitive training, is an ideal intervention for improving cognitive functioning in those with MS. The purpose of this pilot study is to examine the use of DDR as a novel and highly specific exercise intervention to improve mobility and cognition among individuals with MS. We will be guided by the following three specific aims and hypotheses:
Specific Aim 1: Determine if an eight-week exercise program administered using DDR improves dynamic balance in people with MS relative to a wait-list control group.
Hypothesis 1: Dynamic balance as measured by the Berg Balance Scale will be more improved with the DDR intervention than the wait-list control group.
Specific Aim 2: Determine if the DDR intervention, combining fitness and cognitive training, over the course of an eight-week intervention, will have a more positive effect on domains of processing speed and executive control, than a wait-list control group.
Hypothesis 2: The DDR group relative to the wait-list control group, will show significant improvement in cognitive functioning as assessed by the Paced Auditory Serial Addition Test (PASAT), a measure of processing speed, and executive functioning. Specifically, we hypothesize that given severe deficits in processing speed and executive control, participation in a DDR intervention, will result in a significant improvement on the PASAT, a widely used measure to assess cognitive functioning in patients with MS.
Specific Aim 3: We will also examine whether improvements in cognitive processes engendered by DDR on the PASAT will be supported by changes in underlying neural circuits, as inferred from patterns of event-related functional magnetic resonance imaging (fMRI) activation obtained in a 3 Tesla scanner.
Hypothesis 3: Improvements in cognition as indexed by higher accuracy scores and faster reaction time on the PASAT, will be accompanied by a change in the recruitment of underlying neural processes as inferred from functional magnetic resonance imaging. MS participants in the DDR group will show an increase in recruitment of the attentional network, and more specifically the prefrontal and parietal cortices, cortical regions responsible for successful performance on the PASAT task.
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
-
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Ohio
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Columbus、Ohio、アメリカ、43210
- The Ohio State University Atwell Hall
-
-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Expanded Disability Status Score of < 5 and a diagnosis of relapsing-remitting multiple sclerosis
Exclusion Criteria:
- other neurological or orthopedic diagnosis that limits ambulation, age 30-59
研究計画
研究はどのように設計されていますか?
デザインの詳細
- 主な目的:処理
- 割り当て:ランダム化
- 介入モデル:並列代入
- マスキング:独身
武器と介入
参加者グループ / アーム |
介入・治療 |
---|---|
実験的:Dance Dance Revolution game play
Dance Dance Revolution video game play
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Individuals play dance dance revolution 3 times a week for 8 weeks
|
介入なし:control
individuals continue usual care for 8 weeks
|
この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Berg Balance Scale
時間枠:after 8 weeks
|
The Berg Balance scale consists of 14 functional activities that test static and dynamic balance.
Each item is scored on a scale of 0-4 with higher scores indicating better balance
|
after 8 weeks
|
PASAT
時間枠:after 8 weeks
|
The PASAT is a measure of sustained attention, working memory and information processing speed.
|
after 8 weeks
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
4 square step test
時間枠:after 8 weeks
|
requires a person to step rapidly in a multi-directional pattern over a cane.
It predicts fallers
|
after 8 weeks
|
The Activities Specific Balance Confidence Scale
時間枠:after 8 weeks
|
Measures fear of falling.
Subjects rate their balance confidence on 10 items.
|
after 8 weeks
|
GAITRite
時間枠:after 8 weeks
|
individuals walk on a computerized carpet that records spatiotemporal aspects of gait such as velocity and stride length.
|
after 8 weeks
|
6 minute walk test
時間枠:Immediately prior to starting the intervention/control period,, after 8 week intervention/control period and then at an 8 week follow up
|
subjects walk for 6 minutes and distance walked is measured
|
Immediately prior to starting the intervention/control period,, after 8 week intervention/control period and then at an 8 week follow up
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physical activity
時間枠:after 8 weeks
|
subjects wear an accelerometer for 5 days which records how active they are.
|
after 8 weeks
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multiple sclerosis quality of life inventory
時間枠:after 8 weeks
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the MS quality of life inventory is filled out to measure the impact of MS on the individuals quality of life.
|
after 8 weeks
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fMRI
時間枠:after 8 weeks
|
individuals will go into an MRI and undergo neuropsychological and motor testing to examine for neuroplasticity
|
after 8 weeks
|
協力者と研究者
スポンサー
捜査官
- 主任研究者:Ruchika Prakash, PhD、Ohio State University
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
キーワード
追加の関連 MeSH 用語
その他の研究ID番号
- 2011H0048
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