Efficacy of Eccentric Resistance Training in Persons With Knee Osteoarthritis
調査の概要
状態
条件
詳細な説明
Arthritis is the leading cause of disability in the United States. Osteoarthritis (OA) is the most common type of arthritis and affects nearly 27 million Americans. Knee OA is the most common type of osteoarthritis and is estimated to affect 42.1% of women and 31.2% of men over the age of 60.
Osteoarthritis is most likely multi-factorial with several underlying causes. It is no longer considered "a degenerative joint disease" but rather a process that involves dynamic biomechanical, biochemical, and cellular processes. It not only involves degeneration of the articular cartilage, but also inflammation of the synovium, changes to the underlying subchondral bone, and the development of osteophytes. Currently, it appears that numerous systemic factors can lead to the initiation of OA through different causal pathways . These systemic causes can then be amplified by local factors such as trauma or increased loading caused by obesity.
Currently, there is no "cure" for OA and attempts to find a disease modifying drug have been unsuccessful. Thus, treatment currently focuses on mitigating factors that are known to affect the radiographic progression of the disease as well as lead to activity limitation and participation restriction.9,10 Decreases in lower extremity strength are a major cause of activity limitations given the vital role of strength in activities of daily living.
One method that is used to mitigate progressing factors is through the use of an exercise program. Many types of exercise have been used successfully in the literature including resistance training. Resistance training can take many different forms such as isometric, isotonic (concentric and/or eccentric) or isokinetic with various intensities. Presently, there is little evidence for the use of eccentric training interventions for patients with knee OA. This study aims to further examine this type of resistance training for the OA population. Therefore, the purpose of this study is to examine the effects of low intensity, long duration eccentric resistance training and high intensity, short duration eccentric resistance training in individuals with knee OA. Ideally, this study will allow us to determine the overall effects of eccentric resistance training as well as the potential differences of the two types of eccentric resistance training.
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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Colorado
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Denver、Colorado、アメリカ、80221
- Regis University
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
Individuals will be included in the study if they are:
- at least 55 years old,
- cognitively able to understand directions,
- able to ambulate at least 50 feet without stopping,
- are currently experiencing knee pain and
- meet at least 3 out of 6 criteria of the European League Against Rheumatism (EULAR) criteria for knee osteoarthritis diagnosis.
Exclusion Criteria:
Individuals will be excluded from the study if they have:
- a diagnosed medical condition that would limit physical ability, including acute or active fractures, myocardial infarctions, stroke,
- a traumatic brain injury within the last 6 months, or
- joint replacement within the last 12 months. Individuals with chronic neurological disorders limiting motion or present with any known contraindication for balance training will also be excluded from the study.
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：High Intensity Short Duration Exercise
Participants randomized to this group will perform 4 sets of 8-15 repetitions of eccentric exercise using the Eccentron set at 50-80% of the participant's one repetition maximum.
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Participants randomized to this group will perform 4 sets of 8-15 repetitions of eccentric exercise using the Eccentron set at 50-80% of the participant's one repetition maximum.
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実験的：Low Intensity Long Duration Exercise
Participants randomized to this group will perform 5-20 minutes of continuous eccentric exercise using the Eccentron set at 50% of the participant's one repetition maximum.
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Participants randomized to this group will perform 5-20 minutes of continuous eccentric exercise using the Eccentron set at 50% of the participant's one repetition maximum.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Isometric quadriceps strength as measured by a hand held dynamometer
時間枠：Change from baseline to 8 weeks
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The primary outcome for this study is the change in quadriceps strength from baseline to 8 weeks (end of intervention) in both experimental groups.
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Change from baseline to 8 weeks
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Lower extremity muscle strength as measured by a hand held dynamometer
時間枠：Change from baseline to 8 weeks
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Trunk flexion/extension, Hip Abduction/Extension, Knee Flexion/Extension, and Ankle Plantarflexion and Dorsiflexion will be assessed at baseline and 8 weeks by a hand held dynamometer.
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Change from baseline to 8 weeks
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Timed Up and Go Test
時間枠：Change from baseline to 8 weeks
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Change from baseline to 8 weeks
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6-minute Walk Test
時間枠：Change from baseline to 8 weeks
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Change from baseline to 8 weeks
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Five times sit to stand test
時間枠：Change from baseline to 8 weeks
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Change from baseline to 8 weeks
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Balance (assessed utilizing the romberg, sharpened romberg, one-legged stance test, functional reach test, and step test)
時間枠：Change from baseline to 8 weeks
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Balance will be assessed utilizing the romberg, sharpened romberg, one-legged stance test, functional reach test, and step test.
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Change from baseline to 8 weeks
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Arthritis Impact Measurement Scale (AIMS)
時間枠：Change from baseline to 8 weeks
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Change from baseline to 8 weeks
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Pain and muscle soreness ( assessed utilizing a numeric pain rating scale)
時間枠：At the beginning of every treatment session and following every treatment session for the 8 week intervention
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Pain and muscle soreness will be assessed utilizing a numeric pain rating scale at the beginning and end of every treatment session.
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At the beginning of every treatment session and following every treatment session for the 8 week intervention
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協力者と研究者
スポンサー
捜査官
- 主任研究者：Michael J Bade, PT, PhD、Regis University
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。