Efficacy of Eccentric Resistance Training in Persons With Knee Osteoarthritis
Přehled studie
Postavení
Podmínky
Detailní popis
Arthritis is the leading cause of disability in the United States. Osteoarthritis (OA) is the most common type of arthritis and affects nearly 27 million Americans. Knee OA is the most common type of osteoarthritis and is estimated to affect 42.1% of women and 31.2% of men over the age of 60.
Osteoarthritis is most likely multi-factorial with several underlying causes. It is no longer considered "a degenerative joint disease" but rather a process that involves dynamic biomechanical, biochemical, and cellular processes. It not only involves degeneration of the articular cartilage, but also inflammation of the synovium, changes to the underlying subchondral bone, and the development of osteophytes. Currently, it appears that numerous systemic factors can lead to the initiation of OA through different causal pathways . These systemic causes can then be amplified by local factors such as trauma or increased loading caused by obesity.
Currently, there is no "cure" for OA and attempts to find a disease modifying drug have been unsuccessful. Thus, treatment currently focuses on mitigating factors that are known to affect the radiographic progression of the disease as well as lead to activity limitation and participation restriction.9,10 Decreases in lower extremity strength are a major cause of activity limitations given the vital role of strength in activities of daily living.
One method that is used to mitigate progressing factors is through the use of an exercise program. Many types of exercise have been used successfully in the literature including resistance training. Resistance training can take many different forms such as isometric, isotonic (concentric and/or eccentric) or isokinetic with various intensities. Presently, there is little evidence for the use of eccentric training interventions for patients with knee OA. This study aims to further examine this type of resistance training for the OA population. Therefore, the purpose of this study is to examine the effects of low intensity, long duration eccentric resistance training and high intensity, short duration eccentric resistance training in individuals with knee OA. Ideally, this study will allow us to determine the overall effects of eccentric resistance training as well as the potential differences of the two types of eccentric resistance training.
Typ studie
Zápis (Aktuální)
Fáze
- Nelze použít
Kontakty a umístění
Studijní místa
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Colorado
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Denver, Colorado, Spojené státy, 80221
- Regis University
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Kritéria účasti
Kritéria způsobilosti
Věk způsobilý ke studiu
Přijímá zdravé dobrovolníky
Pohlaví způsobilá ke studiu
Popis
Inclusion Criteria:
Individuals will be included in the study if they are:
- at least 55 years old,
- cognitively able to understand directions,
- able to ambulate at least 50 feet without stopping,
- are currently experiencing knee pain and
- meet at least 3 out of 6 criteria of the European League Against Rheumatism (EULAR) criteria for knee osteoarthritis diagnosis.
Exclusion Criteria:
Individuals will be excluded from the study if they have:
- a diagnosed medical condition that would limit physical ability, including acute or active fractures, myocardial infarctions, stroke,
- a traumatic brain injury within the last 6 months, or
- joint replacement within the last 12 months. Individuals with chronic neurological disorders limiting motion or present with any known contraindication for balance training will also be excluded from the study.
Studijní plán
Jak je studie koncipována?
Detaily designu
- Primární účel: Léčba
- Přidělení: Randomizované
- Intervenční model: Paralelní přiřazení
- Maskování: Žádné (otevřený štítek)
Zbraně a zásahy
Skupina účastníků / Arm |
Intervence / Léčba |
|---|---|
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Experimentální: High Intensity Short Duration Exercise
Participants randomized to this group will perform 4 sets of 8-15 repetitions of eccentric exercise using the Eccentron set at 50-80% of the participant's one repetition maximum.
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Participants randomized to this group will perform 4 sets of 8-15 repetitions of eccentric exercise using the Eccentron set at 50-80% of the participant's one repetition maximum.
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Experimentální: Low Intensity Long Duration Exercise
Participants randomized to this group will perform 5-20 minutes of continuous eccentric exercise using the Eccentron set at 50% of the participant's one repetition maximum.
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Participants randomized to this group will perform 5-20 minutes of continuous eccentric exercise using the Eccentron set at 50% of the participant's one repetition maximum.
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Co je měření studie?
Primární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
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Isometric quadriceps strength as measured by a hand held dynamometer
Časové okno: Change from baseline to 8 weeks
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The primary outcome for this study is the change in quadriceps strength from baseline to 8 weeks (end of intervention) in both experimental groups.
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Change from baseline to 8 weeks
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Sekundární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
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Lower extremity muscle strength as measured by a hand held dynamometer
Časové okno: Change from baseline to 8 weeks
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Trunk flexion/extension, Hip Abduction/Extension, Knee Flexion/Extension, and Ankle Plantarflexion and Dorsiflexion will be assessed at baseline and 8 weeks by a hand held dynamometer.
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Change from baseline to 8 weeks
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Timed Up and Go Test
Časové okno: Change from baseline to 8 weeks
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Change from baseline to 8 weeks
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6-minute Walk Test
Časové okno: Change from baseline to 8 weeks
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Change from baseline to 8 weeks
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Five times sit to stand test
Časové okno: Change from baseline to 8 weeks
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Change from baseline to 8 weeks
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Balance (assessed utilizing the romberg, sharpened romberg, one-legged stance test, functional reach test, and step test)
Časové okno: Change from baseline to 8 weeks
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Balance will be assessed utilizing the romberg, sharpened romberg, one-legged stance test, functional reach test, and step test.
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Change from baseline to 8 weeks
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Arthritis Impact Measurement Scale (AIMS)
Časové okno: Change from baseline to 8 weeks
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Change from baseline to 8 weeks
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Pain and muscle soreness ( assessed utilizing a numeric pain rating scale)
Časové okno: At the beginning of every treatment session and following every treatment session for the 8 week intervention
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Pain and muscle soreness will be assessed utilizing a numeric pain rating scale at the beginning and end of every treatment session.
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At the beginning of every treatment session and following every treatment session for the 8 week intervention
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Spolupracovníci a vyšetřovatelé
Sponzor
Vyšetřovatelé
- Vrchní vyšetřovatel: Michael J Bade, PT, PhD, Regis University
Termíny studijních záznamů
Hlavní termíny studia
Začátek studia
Primární dokončení (Aktuální)
Dokončení studie (Aktuální)
Termíny zápisu do studia
První předloženo
První předloženo, které splnilo kritéria kontroly kvality
První zveřejněno (Odhad)
Aktualizace studijních záznamů
Poslední zveřejněná aktualizace (Odhad)
Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality
Naposledy ověřeno
Více informací
Termíny související s touto studií
Další relevantní podmínky MeSH
- Onemocnění kloubů
- Nemoci pohybového aparátu
- Revmatická onemocnění
- Artritida
- Osteoartróza
- Osteoartróza, koleno
- Fyziologické účinky léků
- Adrenergní látky
- Neurotransmiterové látky
- Molekulární mechanismy farmakologického působení
- Autonomní agenti
- Agenti periferního nervového systému
- Adrenergní alfa-agonisté
- Adrenergní agonisté
- Agenti dýchacího systému
- Sympatomimetika
- Vazokonstrikční činidla
- Nosní dekongestanty
- Oxymetazolin
Další identifikační čísla studie
- 15-010
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