Interoception and Illness Perception Before and After Bariatric Surgery: Impact on Disordered Eating (Interoceptiv-BAR)
Interoception and Illness Perception Before and After Bariatric Surgery: Impact on Disordered Eating Behaviors
Obesity is associated with alterations in the perception and interpretation of internal bodily signals (interoception), which may influence eating behaviors, emotional regulation, and long-term weight outcomes. Bariatric surgery induces profound physiological and neurohormonal changes that may affect interoceptive awareness and illness perception, potentially impacting the risk of disordered eating behaviors after surgery.
This observational study aims to evaluate longitudinal changes in interoceptive awareness and illness perception in adults with severe obesity undergoing bariatric surgery, from the pre-operative phase to long-term follow-up. The study also explores the relationship between these psychological constructs and clinical and behavioral outcomes over time.
調査の概要
状態
条件
詳細な説明
Interoception refers to the ability to perceive, interpret, and integrate internal bodily signals and plays a key role in appetite regulation, emotional processing, and eating behavior. Altered interoceptive processing has been associated with obesity, disordered eating behaviors, and psychological distress. In individuals with severe obesity, bariatric surgery represents the most effective treatment for weight reduction; however, the persistence or recurrence of maladaptive eating behaviors after surgery remains a relevant clinical concern.
Bariatric surgery leads to marked modifications in the gut-brain axis, neuroendocrine signaling, and central processing of internal bodily signals. These changes may influence interoceptive awareness and illness perception, which in turn could affect long-term behavioral, psychological, and clinical outcomes. Despite increasing interest in these mechanisms, longitudinal evidence on subjective interoceptive changes and illness perception before and after bariatric surgery remains limited.
This monocentric, longitudinal, ambispective observational study is conducted in adults with severe obesity evaluated for bariatric surgery at a tertiary referral center. Psychological and clinical data are collected during the pre-operative assessment and during post-surgical follow-up, allowing the evaluation of changes over time in interoceptive awareness, illness perception, psychological functioning, and weight-related outcomes.
The study includes both a retrospective component, based on existing clinical data, and a prospective component with repeated assessments over long-term follow-up. By characterizing trajectories of interoceptive awareness and illness perception before and after bariatric surgery, this study aims to improve the understanding of psychological and behavioral factors involved in post-surgical outcomes and to support the development of more personalized multidisciplinary care pathways for patients with severe obesity.
研究の種類
入学 (推定)
連絡先と場所
研究連絡先
- 名前：Maria Rosaria Magurano, PC
- 電話番号：+393663940248
- メール：mariarosaria.magurano@policlinicogemelli.it
研究場所
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Lazio
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Rome、Lazio、イタリア、00168
- 募集
- Fondazione Policlinico Universitario A. Gemelli IRCCS
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コンタクト：
- Maria Rosaria Magurano, PC
- 電話番号：+393663940248
- メール：mariarosaria.magurano@policlinicogemelli.it
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参加基準
適格基準
就学可能な年齢
- 大人
- 高齢者
健康ボランティアの受け入れ
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Adults aged 18 years or older.
- Diagnosis of severe or morbid obesity (body mass index ≥35 kg/m² with obesity-related comorbidities or ≥40 kg/m²).
- Undergoing multidisciplinary evaluation with indication for bariatric surgery.
- Ability to provide informed consent and complete self-administered questionnaires.
Exclusion Criteria:
- Age younger than 18 years.
- Presence of neurological disorders associated with cognitive impairment that may interfere with questionnaire completion.
- Pregnancy or breastfeeding at the time of enrollment.
- Inability to complete study assessments due to language barriers or other conditions limiting participation.
研究計画
研究はどのように設計されていますか？
デザインの詳細
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Change in interoceptive awareness measured by the Multidimensional Assessment of Interoceptive Awareness (MAIA)
時間枠：Baseline to 24 months after bariatric surgery
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Change from baseline to 24 months in MAIA subscale scores.
The MAIA is a validated 32-item self-report questionnaire assessing interoceptive awareness across 8 dimensions.
Each item is rated on a Likert scale, and subscale scores are calculated as the mean of corresponding items.
Higher scores indicate greater interoceptive awareness.
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Baseline to 24 months after bariatric surgery
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Change in illness perception measured by the Illness Perception Questionnaire-Revised (IPQ-R)
時間枠：Baseline to 24 months after bariatric surgery
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Change from baseline to 24 months in cognitive and emotional domains of the IPQ-R. The IPQ-R includes multiple domains assessing illness representations using Likert scales. Higher scores indicate stronger endorsement of the measured dimension (interpretation depends on domain). |
Baseline to 24 months after bariatric surgery
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Anthropometrics
時間枠：Baseline, 12 months, and 24 months after bariatric surgery
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Change in body weight from baseline to 12 and 24 months after bariatric surgery.
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Baseline, 12 months, and 24 months after bariatric surgery
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Changes in Depression
時間枠：Baseline, 12 months, and 24 months after bariatric surgery
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Change in depressive symptoms assessed by the Patient Health Questionnaire-9 (PHQ-9)from baseline to follow-up.
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Baseline, 12 months, and 24 months after bariatric surgery
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Changes in Disordered Eating Behaviors
時間枠：Baseline, 12 months, and 24 months after bariatric surgery
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Change in disordered eating behaviors assessed by the Eating Disorder Examination Questionnaire 6.0 (EDE-Q6)
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Baseline, 12 months, and 24 months after bariatric surgery
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Changes in Psychological Functioning
時間枠：Baseline, 12 months, and 24 months after bariatric surgery
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Change in general psychological functioning assessed by the Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM).
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Baseline, 12 months, and 24 months after bariatric surgery
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Changes in Health-Related Quality of Life
時間枠：Baseline, 12 months, and 24 months after bariatric surgery
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Change in health-related quality of life assessed by the Short Form-36 Health Survey (SF-36).
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Baseline, 12 months, and 24 months after bariatric surgery
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Anthropometrics
時間枠：Time frame: baseline, 12, 24 months
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Change in body mass index (BMI) from baseline to 12 and 24 months after bariatric surgery.
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Time frame: baseline, 12, 24 months
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Changes Anxiety Symptoms
時間枠：Baseline, 12 months, and 24 months after bariatric surgery
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Change in depressive symptoms assessed by the anxiety symptoms assessed by the Generalized Anxiety Disorder-7 (GAD-7) from baseline to follow-up.
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Baseline, 12 months, and 24 months after bariatric surgery
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Changes in Disordered Eating Behaviors 1
時間枠：Baseline, 12 months, and 24 months after bariatric surgery
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Change in disordered eating behaviors assessed by the Binge Eating Scale (BES).
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Baseline, 12 months, and 24 months after bariatric surgery
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Changes in Disordered Eating Behaviors 2
時間枠：Baseline, 12 months, and 24 months after bariatric surgery
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Change in disordered eating behaviors assessed by the Clinical Impairment Assessment (CIA).
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Baseline, 12 months, and 24 months after bariatric surgery
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協力者と研究者
捜査官
- 主任研究者：Maria Rosaria Magurano、Fondazione Policlinico A. Gemelli IRCCS
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
キーワード
その他の研究ID番号
- ID 27168 - Interoceptiv-BAR
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
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