The Effects of Single Exercise Sessions on Cognitive Flexibility and Brain Functional Connectivity in Older Adults With Cognitive Impairment
2026年6月2日 更新者：Ding Feng、Shanghai University of Sport
The Effects of Different Forms of Single Exercise Sessions on Cognitive Flexibility and Brain Functional Connectivity in Older Adults With Cognitive Impairment: A Single-Blind, Multicenter Randomized Controlled Trial
Objectives: To investigate the effects of different forms (physical and mental, aerobic and resistance) of single exercise on the cognitive flexibility and brain functional connectivity of elderly individuals with cognitive impairment.
Clinical trail Methods: This study employed a single-blind, multi-center randomized controlled trial. Sixty elderly individuals with cognitive impairment were recruited and randomly divided into the Qigong group (15 participants), the brisk walking group (15 participants), the elastic band group (15 participants), and the control group (15 participants). Before and after the intervention, 5-minute resting-state electroencephalogram signals were collected and cognitive flexibility tests were conducted. The Qigong group, the brisk walking group, and the elastic band group received single sessions of Qigong, brisk walking, and elastic band exercises respectively, while the control group received health education. The exercise intensity was moderate (target heart rate was 64%-76% of the maximum heart rate), and the exercise duration was 30 minutes.
調査の概要
研究の種類
介入
入学 (実際)
60
段階
- 適用できない
連絡先と場所
このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。
研究場所
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Shanghai、中国
- Shanghai University of Sport
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参加基準
研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。
適格基準
就学可能な年齢
- 大人
- 高齢者
健康ボランティアの受け入れ
いいえ
説明
Inclusion Criteria:
- Age ≥ 60 years old, gender not restricted;
- Patients or their guardians report subjective cognitive decline;
- Montreal Cognitive Function Assessment Scale < 26 points;
- Duration of cognitive dysfunction ≥ 6 months;
- Willing to sign the informed consent form;
- Good physical condition and able to complete the test;
- Right-handed.
Exclusion Criteria:
- History of severe mental disorders (severe depression, schizophrenia, etc.);
- Using drugs that affect cognition (such as sedatives, antidepressants, etc.);
- Limited language ability;
- Consumed caffeine or alcohol the day before the test;
- Suffering from serious diseases or injuries that make participation in the test inappropriate.
研究計画
このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：独身
武器と介入
参加者グループ / アーム |
介入・治療 |
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実験的：Baduanjin group
This study adopted the Baduanjin Health Qigong standard issued by the General Administration of Sport of China in 2003. .
The exercise intervention lasted 30 min in total, including a 2-min preparation phase, a 26-min main phase and a 2-min cool-down phase.
Two weeks before the formal intervention, participants received training from a martial arts professional coach, and only those who had achieved fluent and proficient performance of the movements were allowed to take part in the formal intervention.
Participants were required not to engage in any exercise during the 3 days before the intervention.
The Baduanjin group received movement instruction from a professional martial arts coach and performed the exercise in an indoor dance room.
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exercise programm
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実験的：Brisk walking group
This study adopted the Brisk Walking standard issued by the General Administration of Sport of China in 2017.
A treadmill manufactured by Topkang Technology Co., Ltd.
(model: SJAI) was used.
The exercise intervention lasted 30 min in total, including a 2-min preparation phase, a 26-min main phase and a 2-min cool-down phase.
Before the intervention, participants received instruction and training from a professional track-and-field coach, and only those who had achieved fluent and proficient performance of the movements were allowed to participate in the formal intervention.
Participants were required not to engage in any exercise during the 3 days before the intervention.
The brisk walking group received movement instruction from a professional track-and-field coach and performed the exercise on an indoor treadmill.
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exercise programm
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実験的：Resistance band group
The resistance exercise programme in this study was based on the framework of the American College of Sports Medicine (ACSM) guidelines.
A portable and safe resistance band (TheraBand progressive resistance band, USA) was used as the intervention tool.
The resistance-band resistance training consisted of 10 exercises in total, including 4 upper-limb movements (seated chest press, seated reverse fly, seated biceps curl and seated shoulder press) and 6 lower-limb movements (seated knee lift, seated knee extension, seated knee flexion, seated leg press, seated hip abduction and standing calf raise).
Each movement was performed for 2 sets of 12 repetitions.
Rest intervals were 30-60 s within sets and 30-60 s between sets, and the movement tempo was controlled at 2 s for the eccentric phase and 2 s for the concentric phase.
The resistance-band group received movement instruction from a professional fitness coach and performed the exercise in an indoor activity room.
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exercise programm
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アクティブコンパレータ：Control group
After arrival, participants in the control group watched health education materials and received health education at the community activity center.
Detailed descriptions of the exercise interventions for the four groups are provided in the Supplementary Materials.
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health education materials
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
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Cognitive flexibility
時間枠：A total of 8 months from the beginning to the end
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Cognitive flexibility was assessed using the More-odd-shifting task paradigm, which was designed with E-prime software.
The testing environment was quiet, well ventilated and moderately lit.
The stimuli used in the More-odd-shifting task were red or green Arabic numerals from 1 to 9, excluding 5. Participants were required to make key-press responses according to the task instructions when the stimuli appeared.
The More-odd-shifting task consisted of three conditions: Condition 1, judgment of numerical magnitude; Condition 2, judgment of parity; and Condition 3, mixed judgment of numerical magnitude and parity.
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A total of 8 months from the beginning to the end
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
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Brain functional connectivity
時間枠：A total of 8 months from the beginning to the end
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Brain functional connectivity analysis was performed using MATLAB scripts, and graph-theoretical analysis was carried out using the BrainNet Viewer toolbox.
Phase locking value (PLV) was used, and brain functional connectivity was evaluated from two dimensions: connectivity strength and density.
In this study, PLV was calculated for the δ, θ, α1, α2, β1 and β2 bands of resting-state EEG using MATLAB, and the formula is shown in Equation (1).
Here, i is the imaginary unit, Δt is the time interval between two consecutive samples, and N is the total number of samples.
PLV is an index used to quantify phase synchrony in EEG signals and assesses whether two signals maintain a relatively stable phase relationship over time.
Its value ranges from 0 to 1, where 1 indicates complete synchrony and 0 indicates no synchrony.
PLV is commonly used to investigate phase synchrony between different brain regions, particularly functional connectivity related to neural oscillations.
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A total of 8 months from the beginning to the end
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協力者と研究者
ここでは、この調査に関係する人々や組織を見つけることができます。
研究記録日
これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。
主要日程の研究
研究開始 (実際)
2025年6月30日
一次修了 (実際)
2026年1月10日
研究の完了 (実際)
2026年1月20日
試験登録日
最初に提出
2026年5月21日
QC基準を満たした最初の提出物
2026年6月2日
最初の投稿 (実際)
2026年6月3日
学習記録の更新
投稿された最後の更新 (実際)
2026年6月3日
QC基準を満たした最後の更新が送信されました
2026年6月2日
最終確認日
2026年5月1日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
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