The Effects of Single Exercise Sessions on Cognitive Flexibility and Brain Functional Connectivity in Older Adults With Cognitive Impairment
2026年6月2日 更新者：Ding Feng、Shanghai University of Sport
The Effects of Different Forms of Single Exercise Sessions on Cognitive Flexibility and Brain Functional Connectivity in Older Adults With Cognitive Impairment: A Single-Blind, Multicenter Randomized Controlled Trial
Objectives: To investigate the effects of different forms (physical and mental, aerobic and resistance) of single exercise on the cognitive flexibility and brain functional connectivity of elderly individuals with cognitive impairment.
Clinical trail Methods: This study employed a single-blind, multi-center randomized controlled trial. Sixty elderly individuals with cognitive impairment were recruited and randomly divided into the Qigong group (15 participants), the brisk walking group (15 participants), the elastic band group (15 participants), and the control group (15 participants). Before and after the intervention, 5-minute resting-state electroencephalogram signals were collected and cognitive flexibility tests were conducted. The Qigong group, the brisk walking group, and the elastic band group received single sessions of Qigong, brisk walking, and elastic band exercises respectively, while the control group received health education. The exercise intensity was moderate (target heart rate was 64%-76% of the maximum heart rate), and the exercise duration was 30 minutes.
研究概览
研究类型
介入性
注册 (实际的)
60
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
-
-
-
Shanghai、中国
- Shanghai University of Sport
-
-
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
不
描述
Inclusion Criteria:
- Age ≥ 60 years old, gender not restricted;
- Patients or their guardians report subjective cognitive decline;
- Montreal Cognitive Function Assessment Scale < 26 points;
- Duration of cognitive dysfunction ≥ 6 months;
- Willing to sign the informed consent form;
- Good physical condition and able to complete the test;
- Right-handed.
Exclusion Criteria:
- History of severe mental disorders (severe depression, schizophrenia, etc.);
- Using drugs that affect cognition (such as sedatives, antidepressants, etc.);
- Limited language ability;
- Consumed caffeine or alcohol the day before the test;
- Suffering from serious diseases or injuries that make participation in the test inappropriate.
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：单身的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：Baduanjin group
This study adopted the Baduanjin Health Qigong standard issued by the General Administration of Sport of China in 2003. .
The exercise intervention lasted 30 min in total, including a 2-min preparation phase, a 26-min main phase and a 2-min cool-down phase.
Two weeks before the formal intervention, participants received training from a martial arts professional coach, and only those who had achieved fluent and proficient performance of the movements were allowed to take part in the formal intervention.
Participants were required not to engage in any exercise during the 3 days before the intervention.
The Baduanjin group received movement instruction from a professional martial arts coach and performed the exercise in an indoor dance room.
|
exercise programm
|
|
实验性的：Brisk walking group
This study adopted the Brisk Walking standard issued by the General Administration of Sport of China in 2017.
A treadmill manufactured by Topkang Technology Co., Ltd.
(model: SJAI) was used.
The exercise intervention lasted 30 min in total, including a 2-min preparation phase, a 26-min main phase and a 2-min cool-down phase.
Before the intervention, participants received instruction and training from a professional track-and-field coach, and only those who had achieved fluent and proficient performance of the movements were allowed to participate in the formal intervention.
Participants were required not to engage in any exercise during the 3 days before the intervention.
The brisk walking group received movement instruction from a professional track-and-field coach and performed the exercise on an indoor treadmill.
|
exercise programm
|
|
实验性的：Resistance band group
The resistance exercise programme in this study was based on the framework of the American College of Sports Medicine (ACSM) guidelines.
A portable and safe resistance band (TheraBand progressive resistance band, USA) was used as the intervention tool.
The resistance-band resistance training consisted of 10 exercises in total, including 4 upper-limb movements (seated chest press, seated reverse fly, seated biceps curl and seated shoulder press) and 6 lower-limb movements (seated knee lift, seated knee extension, seated knee flexion, seated leg press, seated hip abduction and standing calf raise).
Each movement was performed for 2 sets of 12 repetitions.
Rest intervals were 30-60 s within sets and 30-60 s between sets, and the movement tempo was controlled at 2 s for the eccentric phase and 2 s for the concentric phase.
The resistance-band group received movement instruction from a professional fitness coach and performed the exercise in an indoor activity room.
|
exercise programm
|
|
有源比较器：Control group
After arrival, participants in the control group watched health education materials and received health education at the community activity center.
Detailed descriptions of the exercise interventions for the four groups are provided in the Supplementary Materials.
|
health education materials
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Cognitive flexibility
大体时间：A total of 8 months from the beginning to the end
|
Cognitive flexibility was assessed using the More-odd-shifting task paradigm, which was designed with E-prime software.
The testing environment was quiet, well ventilated and moderately lit.
The stimuli used in the More-odd-shifting task were red or green Arabic numerals from 1 to 9, excluding 5. Participants were required to make key-press responses according to the task instructions when the stimuli appeared.
The More-odd-shifting task consisted of three conditions: Condition 1, judgment of numerical magnitude; Condition 2, judgment of parity; and Condition 3, mixed judgment of numerical magnitude and parity.
|
A total of 8 months from the beginning to the end
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Brain functional connectivity
大体时间：A total of 8 months from the beginning to the end
|
Brain functional connectivity analysis was performed using MATLAB scripts, and graph-theoretical analysis was carried out using the BrainNet Viewer toolbox.
Phase locking value (PLV) was used, and brain functional connectivity was evaluated from two dimensions: connectivity strength and density.
In this study, PLV was calculated for the δ, θ, α1, α2, β1 and β2 bands of resting-state EEG using MATLAB, and the formula is shown in Equation (1).
Here, i is the imaginary unit, Δt is the time interval between two consecutive samples, and N is the total number of samples.
PLV is an index used to quantify phase synchrony in EEG signals and assesses whether two signals maintain a relatively stable phase relationship over time.
Its value ranges from 0 to 1, where 1 indicates complete synchrony and 0 indicates no synchrony.
PLV is commonly used to investigate phase synchrony between different brain regions, particularly functional connectivity related to neural oscillations.
|
A total of 8 months from the beginning to the end
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2025年6月30日
初级完成 (实际的)
2026年1月10日
研究完成 (实际的)
2026年1月20日
研究注册日期
首次提交
2026年5月21日
首先提交符合 QC 标准的
2026年6月2日
首次发布 (实际的)
2026年6月3日
研究记录更新
最后更新发布 (实际的)
2026年6月3日
上次提交的符合 QC 标准的更新
2026年6月2日
最后验证
2026年5月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.