Effectiveness of Systane PRO for Mild to Moderate Dry Eye Disease (SYSTANEPRO1)
The Effectiveness of Systane PRO in Providing Relief From Multiple Symptoms of Dry Eye Disease and Its Impact on Daily Functioning and Overall Comfort in Patients With Mild to Moderate Dry Eye Disease
調査の概要
詳細な説明
30 eligible participants with mild-moderate dry eye disease (DED) will be enrolled based on predefined Inclusion/Exclusion criteria. All assessments are performed on Day 0, capturing the initial status of several subject-reported symptoms and clinical features of DED. Participants will then commence daily administration of Systane PRO, QID, will be reassessed after 30 days of continuous use. All initial assessments will be repeated on Day 30 to generate paired data for all subject-reported and clinical data. This paired design will minimize cross-subject variability and improve the statistical power of the study.
Subject-reported symptoms of DED will be assessed by: the Ocular Surface Disease Index (OSDI) questionnaire, the Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire, Visual Analog Scale (VAS) Questionnaires for Ocular Stinging and Grittiness, and the Work Productivity and Activity Impairment (WPAI) questionnaire for DED. These instruments provide comprehensive insight into patient experience, capturing frequency, severity, and the daily impact of symptoms.
Clinical measurements include: LogMAR-converted Best-Corrected Distance Visual Acuity (BCDVA), Corneal Fluorescein Staining (NEI Scale), and Tear Breakup Time 6 of 13 (TBUT). Collectively, these clinical measurements will serve as secondary endpoints for this study and will be used to corroborate any changes observed in the primary endpoint, change in OSDI score.
Additionally, a Manifest Refraction will be performed once at baseline to assess BCDVA, the same refraction will be used to assess BCDVA at Day 30. A Wratten-12 filter will be utilized for Corneal Fluorescein Staining Grading and Tear Breakup Time assessments to facilitate accurate visualization of the tear film.
At study completion, changes from baseline in both subjective and objective measures are systematically analyzed according to the Statistical Analysis Plan.
研究の種類
入学 (実際)
段階
- フェーズ 4
連絡先と場所
研究場所
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California
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La Jolla、California、アメリカ、92037
- Gordon Schanzlin New Vision Institute
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参加基準
適格基準
就学可能な年齢
- 大人
- 高齢者
健康ボランティアの受け入れ
説明
Inclusion Criteria:
- Patients aged 18 and older with mild-moderate DED (as determined by an OSDI score between 13-22).
Exclusion Criteria:
- Patients unwilling to discontinue all concomitant ophthalmic medications and dry eye therapies for the duration of the study.
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：なし
- 介入モデル：単一グループの割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
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実験的：The Effectiveness of Systane PRO in providing relief from multiple symptoms of dry eye disease, and
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To show that consistent use of Systane PRO will significantly improve the signs and symptoms of Dry Eye Disease in patients with mild-moderate DED.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Change in Ocular Surface Disease Index (OSDI) Score From Baseline to Day 30
時間枠：From enrollment to the end of participation at 28 days
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The OSDI is a validated 12-item questionnaire used to assess dry eye symptoms and their impact on vision-related functioning. Scores range from 0 to 100, with higher scores indicating more severe dry eye symptoms and worse ocular surface disease. Lower scores indicate improvement. Change in OSDI Score will be analyzed with a Wilcoxon signed-rank test comparing Baseline vs. Follow-up. Median change and the proportion of subjects with a ≥4.5-point decrease in score will be reported. |
From enrollment to the end of participation at 28 days
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協力者と研究者
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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