Cardiovascular Autonomic Function After Resistance Training
Effects of 8-Week Resistance Training on Cardiovascular Autonomic Function in Spinal Cord Injury
The purpose of this clinical trial is to evaluate whether an 8-week upper-limb resistance training program improves cardiovascular autonomic function in adults with chronic spinal cord injury (SCI). The primary objectives are to determine whether upper-limb resistance training improves heart rate variability (HRV) and baroreflex sensitivity (BRS), and whether it improves blood pressure responses during postural change, upper-limb strength, symptoms related to orthostatic hypotension, and quality of life.
Participants will be randomly assigned to either the resistance training group or the control group. All participants will complete assessments before and after the 8-week study period, including measurements of HRV, BRS, blood pressure responses during a tilt-table test, hand grip strength, and questionnaires assessing orthostatic hypotension symptoms and quality of life. Participants assigned to the resistance training group will participate in supervised upper-limb resistance training three times per week for 8 weeks.
調査の概要
詳細な説明
SCI can impair cardiovascular autonomic function by disrupting the neural pathways that regulate heart rate and blood pressure. As a result, many individuals with SCI experience cardiovascular autonomic dysfunction, including orthostatic hypotension, which may increase cardiovascular health risks.
Although exercise is recommended for people with SCI, previous studies have mainly focused on aerobic exercise and have demonstrated inconsistent effects on cardiovascular autonomic function. Upper-limb resistance training is widely used in rehabilitation to improve strength and functional independence, but its effects on autonomic function have not been well established.
This randomized controlled trial will evaluate whether an 8-week upper-limb resistance training program improves cardiovascular autonomic function in adults with chronic SCI. The study will assess changes in HRV and BRS, while also exploring changes in orthostatic blood pressure responses, upper-limb strength, orthostatic hypotension symptoms, and quality of life. The findings may provide evidence supporting upper-limb resistance training as a rehabilitation strategy to improve cardiovascular autonomic function in individuals with chronic SCI.
研究の種類
入学 (推定)
段階
- 適用できない
連絡先と場所
研究連絡先
- 名前：Dogyu Lee, M.S.
- 電話番号：055-360-1730
- メール：2doq2doq@gmail.com
研究連絡先のバックアップ
- 名前：Yuna Kim, B.S.
- 電話番号：055-360-1730
- メール：kyoona1289@gmail.com
研究場所
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Gyeongsangnam-do
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Yangsan、Gyeongsangnam-do、韓国、50612
- Pusan National University Yangsan Hospital
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コンタクト：
- Dogyu Lee, M.S.
- 電話番号：055-360-1730
- メール：2doq2doq@gmail.com
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コンタクト：
- Yuna Kim, B.S.
- 電話番号：055-360-1730
- メール：kyoona1289@gmail.com
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主任研究者：
- Sungchul Huh, MD, PhD
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参加基準
適格基準
就学可能な年齢
- 大人
- 高齢者
健康ボランティアの受け入れ
説明
Inclusion Criteria:
- Provided written informed consent and agreed to participate in the study.
- Adults aged 19 to 85 years.
- Chronic spinal cord injury (SCI) of traumatic or non-traumatic etiology, at least 6 months after injury.
- Cervical or thoracic spinal cord injury.
- Classified as American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade A, B, C, or D.
- Sufficient upper-limb range of motion to perform resistance training.
- Elbow extensor muscle strength of Manual Muscle Test (MMT) grade 3 or higher.
Exclusion Criteria:
- Presence of any serious medical condition that would preclude participation in the study.
- Inability to understand or perform the exercise program.
- Uncontrolled diabetes mellitus or progressive neurological disease.
- Uncontrolled hypertension (systolic blood pressure >140 mmHg or diastolic blood pressure >90 mmHg).
- History of cardiovascular disease within the past 6 months.
- Current use of medications that may affect heart rate variability (HRV) or baroreflex sensitivity (BRS).
- Severe orthostatic hypotension (OH) or autonomic dysreflexia (AD).
- Considered unsuitable for participation in the study by a board-certified specialist in Physical and Rehabilitation Medicine.
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Exercise group
Participants will receive a supervised upper-limb resistance training program three times per week for 8 weeks.
The program consists of progressive resistance exercises for the upper extremities.
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Participants will perform a supervised upper-limb resistance training program three times per week for 8 weeks.
Each session will last approximately 30 minutes and consist of progressive resistance exercises for the upper extremities.
Exercise intensity will be progressively adjusted according to each participant's tolerance.
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介入なし：Control group
Participants will continue their usual daily activities without participating in the resistance training program during the 8-week study period.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Heart Rate Variability
時間枠：Baseline and Week 8
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Heart rate variability will be assessed to evaluate changes in cardiovascular autonomic function following the 8-week intervention.
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Baseline and Week 8
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Baroreflex Sensitivity
時間枠：Baseline and Week 8
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Baroreflex sensitivity will be assessed to evaluate changes in cardiovascular autonomic function following the 8-week intervention.
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Baseline and Week 8
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Orthostatic Hypotension
時間枠：Baseline and Week 8
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Orthostatic hypotension will be assessed by changes in systolic and diastolic blood pressure (ΔSBP and ΔDBP) during postural change using a tilt table.
Orthostatic hypotension will be defined as a decrease in systolic blood pressure of ≥20 mmHg or diastolic blood pressure of ≥10 mmHg.
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Baseline and Week 8
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Grip Strength
時間枠：Baseline and Week 8
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Grip strength will be measured using a hand dynamometer to evaluate changes in upper-limb muscle strength following the intervention.
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Baseline and Week 8
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Orthostatic Hypotension Symptoms (ADFSCI)
時間枠：Baseline and Week 8
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Orthostatic hypotension-related symptoms will be assessed using the orthostatic hypotension items of the Autonomic Dysfunction Following Spinal Cord Injury (ADFSCI) questionnaire.
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Baseline and Week 8
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Quality of Life (WHOQOL-BREF)
時間枠：Baseline and Week 8
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Quality of life will be assessed using the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire.
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Baseline and Week 8
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協力者と研究者
捜査官
- 主任研究者：Sungchul Huh, MD, PhD、Pusan National University Yangsan Hospital
研究記録日
主要日程の研究
研究開始 (推定)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
その他の研究ID番号
- 11-2026-006
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
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