Cardiovascular Autonomic Function After Resistance Training
Effects of 8-Week Resistance Training on Cardiovascular Autonomic Function in Spinal Cord Injury
The purpose of this clinical trial is to evaluate whether an 8-week upper-limb resistance training program improves cardiovascular autonomic function in adults with chronic spinal cord injury (SCI). The primary objectives are to determine whether upper-limb resistance training improves heart rate variability (HRV) and baroreflex sensitivity (BRS), and whether it improves blood pressure responses during postural change, upper-limb strength, symptoms related to orthostatic hypotension, and quality of life.
Participants will be randomly assigned to either the resistance training group or the control group. All participants will complete assessments before and after the 8-week study period, including measurements of HRV, BRS, blood pressure responses during a tilt-table test, hand grip strength, and questionnaires assessing orthostatic hypotension symptoms and quality of life. Participants assigned to the resistance training group will participate in supervised upper-limb resistance training three times per week for 8 weeks.
研究概览
详细说明
SCI can impair cardiovascular autonomic function by disrupting the neural pathways that regulate heart rate and blood pressure. As a result, many individuals with SCI experience cardiovascular autonomic dysfunction, including orthostatic hypotension, which may increase cardiovascular health risks.
Although exercise is recommended for people with SCI, previous studies have mainly focused on aerobic exercise and have demonstrated inconsistent effects on cardiovascular autonomic function. Upper-limb resistance training is widely used in rehabilitation to improve strength and functional independence, but its effects on autonomic function have not been well established.
This randomized controlled trial will evaluate whether an 8-week upper-limb resistance training program improves cardiovascular autonomic function in adults with chronic SCI. The study will assess changes in HRV and BRS, while also exploring changes in orthostatic blood pressure responses, upper-limb strength, orthostatic hypotension symptoms, and quality of life. The findings may provide evidence supporting upper-limb resistance training as a rehabilitation strategy to improve cardiovascular autonomic function in individuals with chronic SCI.
研究类型
注册 (估计的)
阶段
- 不适用
联系人和位置
学习联系方式
- 姓名：Dogyu Lee, M.S.
- 电话号码：055-360-1730
- 邮箱：2doq2doq@gmail.com
研究联系人备份
- 姓名：Yuna Kim, B.S.
- 电话号码：055-360-1730
- 邮箱：kyoona1289@gmail.com
学习地点
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Gyeongsangnam-do
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Yangsan、Gyeongsangnam-do、韩国、50612
- Pusan National University Yangsan Hospital
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接触：
- Dogyu Lee, M.S.
- 电话号码：055-360-1730
- 邮箱：2doq2doq@gmail.com
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接触：
- Yuna Kim, B.S.
- 电话号码：055-360-1730
- 邮箱：kyoona1289@gmail.com
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首席研究员：
- Sungchul Huh, MD, PhD
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参与标准
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
描述
Inclusion Criteria:
- Provided written informed consent and agreed to participate in the study.
- Adults aged 19 to 85 years.
- Chronic spinal cord injury (SCI) of traumatic or non-traumatic etiology, at least 6 months after injury.
- Cervical or thoracic spinal cord injury.
- Classified as American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade A, B, C, or D.
- Sufficient upper-limb range of motion to perform resistance training.
- Elbow extensor muscle strength of Manual Muscle Test (MMT) grade 3 or higher.
Exclusion Criteria:
- Presence of any serious medical condition that would preclude participation in the study.
- Inability to understand or perform the exercise program.
- Uncontrolled diabetes mellitus or progressive neurological disease.
- Uncontrolled hypertension (systolic blood pressure >140 mmHg or diastolic blood pressure >90 mmHg).
- History of cardiovascular disease within the past 6 months.
- Current use of medications that may affect heart rate variability (HRV) or baroreflex sensitivity (BRS).
- Severe orthostatic hypotension (OH) or autonomic dysreflexia (AD).
- Considered unsuitable for participation in the study by a board-certified specialist in Physical and Rehabilitation Medicine.
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：Exercise group
Participants will receive a supervised upper-limb resistance training program three times per week for 8 weeks.
The program consists of progressive resistance exercises for the upper extremities.
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Participants will perform a supervised upper-limb resistance training program three times per week for 8 weeks.
Each session will last approximately 30 minutes and consist of progressive resistance exercises for the upper extremities.
Exercise intensity will be progressively adjusted according to each participant's tolerance.
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无干预：Control group
Participants will continue their usual daily activities without participating in the resistance training program during the 8-week study period.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Heart Rate Variability
大体时间：Baseline and Week 8
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Heart rate variability will be assessed to evaluate changes in cardiovascular autonomic function following the 8-week intervention.
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Baseline and Week 8
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Baroreflex Sensitivity
大体时间：Baseline and Week 8
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Baroreflex sensitivity will be assessed to evaluate changes in cardiovascular autonomic function following the 8-week intervention.
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Baseline and Week 8
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Orthostatic Hypotension
大体时间：Baseline and Week 8
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Orthostatic hypotension will be assessed by changes in systolic and diastolic blood pressure (ΔSBP and ΔDBP) during postural change using a tilt table.
Orthostatic hypotension will be defined as a decrease in systolic blood pressure of ≥20 mmHg or diastolic blood pressure of ≥10 mmHg.
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Baseline and Week 8
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Grip Strength
大体时间：Baseline and Week 8
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Grip strength will be measured using a hand dynamometer to evaluate changes in upper-limb muscle strength following the intervention.
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Baseline and Week 8
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Orthostatic Hypotension Symptoms (ADFSCI)
大体时间：Baseline and Week 8
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Orthostatic hypotension-related symptoms will be assessed using the orthostatic hypotension items of the Autonomic Dysfunction Following Spinal Cord Injury (ADFSCI) questionnaire.
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Baseline and Week 8
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Quality of Life (WHOQOL-BREF)
大体时间：Baseline and Week 8
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Quality of life will be assessed using the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire.
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Baseline and Week 8
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合作者和调查者
调查人员
- 首席研究员：Sungchul Huh, MD, PhD、Pusan National University Yangsan Hospital
研究记录日期
研究主要日期
学习开始 (估计的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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