Dose-Response and Phase-Specific Effects of Graded Cognitive Load on Functional Mobility in Older Adults: A Kinematic Analysis (CL)
調査の概要
詳細な説明
Aging is associated with progressive changes in both the central nervous system and the musculoskeletal system, leading to declines in motor performance, balance, and functional mobility. These changes include reduced cortical processing efficiency, slower information processing speed, and alterations in sensorimotor integration, all of which contribute to decreased movement efficiency in older adults. Functional mobility, particularly walking and transitional movements, is no longer considered a purely automatic motor task, but rather a cognitively mediated activity that requires continuous interaction between attentional resources and motor control systems. Clinically, previous studies have demonstrated that dual-task performance is strongly associated with fall risk and mobility impairment in older adults, suggesting 6 its importance in functional assessment and rehabilitation planning.Despite these advances, most of the existing research has primarily focused on binary dual-task paradigms, comparing single-task versus dual-task conditions without considering different levels of cognitive demand. This approach limits the ability to understand whether cognitive-motor interference follows a dose-response relationship, where progressively increasing cognitive load produces graded deterioration in motor performance. Furthermore, while overall gait and mobility outcomes have been widely investigated, there is a lack of detailed evidence regarding how cognitive load influences specific phases of functional mobility tasks, such as sit-to-stand, gait, turning, and stand-to-sit transitions. Previous studies suggest that different movement phases may vary in their sensitivity to cognitive interference due to differences in biomechanical and postural control demands. However, this phasespecific behavior remains underexplored, particularly in the context of graded cognitive loading.
Therefore, there is a clear gap in the literature regarding the combined effect of graded cognitive load and phase-specific motor behavior during functional mobility tasks.
研究の種類
入学 (推定)
段階
- 適用できない
連絡先と場所
研究連絡先
- 名前：mostafa seliem, master
- 電話番号：01554049062
- メール：mostafasleim92@gmail.com
参加基準
適格基準
就学可能な年齢
- 大人
- 高齢者
健康ボランティアの受け入れ
説明
Inclusion Criteria:
- Age ≥ 60 years
- Ability to ambulate independently without assistive devices
- Ability to follow verbal instructions and perform dual-task activities
- Medically stable and capable of participating in functional mobility assessment Cognitive function within normal range, defined as Mini-Mental State Examination (MMSE) score ≥ 24 out of 30, indicating absence of significant cognitive impairment .
- Functionqal independence in basic activities of daily living, defined as Barthel Index score ≥ 90 out of 100
- Body Mass Index (BMI) between 18.5 and 29.9 kg/m², as values ≥ 30 kg/m² (obesity) may adversely affect gait and balance performance.
Exclusion Criteria:
- Any neurological disease that affects walking or balance, such as stroke or Parkinson's disease
- Any musculoskeletal condition that limits lower-limb movement or affects normal walking patterns
- Severe cognitive impairment defined as Mini-Mental State Examination (MMSE) score < 24
- Visual, vestibular, or hearing problems that affect safe walking or balance control
- History of lower-limb injury or surgery within the last 6 months
- Serious medical conditions that make participation unsafe, such as unstable cardiac or respiratory disease
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：なし
- 介入モデル：単一グループの割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
|
実験的：Dual-Task Cognitive Loading Protocol
sixty Participants will perform the time-up-and-go test under four standardized experimental conditions designed to investigate the dose-response and phase-specific effects of graded cognitive load on functional mobility in older adults.
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Participants will perform the TUG test under four standardized experimental conditions: 1. Single-Task Condition (Baseline) : Participants will perform TUG test without any additional cognitive task. 2-Low Cognitive Load Condition:Participants will perform the TUG test while simultaneously performing simple backward counting by ones starting from a randomly assigned number between 90 and 100. 3-Moderate Cognitive Load Condition :Participants will perform the TUG test while simultaneously performing serial backward counting by threes starting from a randomly assigned number between 90 and 100. 4-High Cognitive Load Condition:Participants will perform the TUG test while simultaneously performing serial subtraction by sevens (Serial 7s task) starting from a randomly assigned number between 90 and 100. |
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Timed Up and Go (TUG) Completion Time
時間枠：up to one day
|
A smartwatch will be used to assess the completion time of the TUG test.
The total time required to complete the TUG test under each cognitive load condition will be recorded in seconds and used as the primary measure of functional mobility performance.
Increased TUG completion time will indicate deterioration in functional mobility under cognitive interference conditions
|
up to one day
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
sit-to-stand phase time
時間枠：up to one day
|
A smartwatch will be used to assess the time of sit-to-stand phase as a part of the TUG test
|
up to one day
|
|
walking phase time
時間枠：up to one day
|
The smartwatch will be used to assess the time of the walking phase as a part of TUG test
|
up to one day
|
|
turning phase time
時間枠：up to one day
|
The smartwatch will be used to assess the time of the turning phase as a part of TUG test
|
up to one day
|
|
stand-to-sit phase
時間枠：up to one day
|
The smartwatch will be used to assess the time of the stand-to-sit phase as a part of TUG tes
|
up to one day
|
|
gait speed
時間枠：up to one day
|
A sagittal-plane video-based kinematic analysis system will be used to evaluate gait speed.ormal
gait speed for healthy adults generally ranges from 1.2 to 1.4 meters per second (m/s)
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up to one day
|
|
step length
時間枠：up to one day
|
A sagittal-plane video-based kinematic analysis system will be used to evaluate step length.
The normal walking step length is about 2.5 feet (75 to 79 cm) for men and 2.2 feet (66 to 69 cm) for women
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up to one day
|
|
cadence
時間枠：up to one day
|
A sagittal-plane video-based kinematic analysis system will be used to evaluate cadence.
A normal comfortable walking cadence for healthy adults generally ranges from 100 to 120 steps per minute
|
up to one day
|
|
step time
時間枠：up to one day
|
A sagittal-plane video-based kinematic analysis system will be used to evaluate step time.
the normal step time for a healthy adult walking at a comfortable, self-selected speed is approximately 0.5 seconds per single step
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up to one day
|
|
turning duration
時間枠：up to one day
|
A sagittal-plane video-based kinematic analysis system will be used to evaluate turning duration.For healthy, normal adults, the average turning durations typically fall into these ranges from 1.4 to 1.5 seconds
|
up to one day
|
|
peak trunk flexion angle
時間枠：up to one day
|
sagittal-plane video-based kinematic analysis system will be used to evaluate peak trunk flexion.Studies show that actively flexing the trunk increases peak angles (reaching higher ranges like an added 47° in intentional flexed landings vs. preferred landings) which helps absorb impact and protect the knees
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up to one day
|
|
peak hip flexion angle
時間枠：up to one day
|
the sagittal-plane video-based kinematic analysis system will be used to evaluate peak hip flexion angle.
it should be from 130-140 degree.
|
up to one day
|
|
peak knee flexion angle
時間枠：up to one day
|
The sagittal-plane video-based kinematic analysis system will be used to evaluate peak knee flexion angle.
it should be from 120-150 degree.
|
up to one day
|
協力者と研究者
スポンサー
研究記録日
主要日程の研究
研究開始 (推定)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
その他の研究ID番号
- P.T.REC/012/006633
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
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