Dose-Response and Phase-Specific Effects of Graded Cognitive Load on Functional Mobility in Older Adults: A Kinematic Analysis (CL)
Studie Overzicht
Toestand
Conditie
Interventie / Behandeling
Gedetailleerde beschrijving
Aging is associated with progressive changes in both the central nervous system and the musculoskeletal system, leading to declines in motor performance, balance, and functional mobility. These changes include reduced cortical processing efficiency, slower information processing speed, and alterations in sensorimotor integration, all of which contribute to decreased movement efficiency in older adults. Functional mobility, particularly walking and transitional movements, is no longer considered a purely automatic motor task, but rather a cognitively mediated activity that requires continuous interaction between attentional resources and motor control systems. Clinically, previous studies have demonstrated that dual-task performance is strongly associated with fall risk and mobility impairment in older adults, suggesting 6 its importance in functional assessment and rehabilitation planning.Despite these advances, most of the existing research has primarily focused on binary dual-task paradigms, comparing single-task versus dual-task conditions without considering different levels of cognitive demand. This approach limits the ability to understand whether cognitive-motor interference follows a dose-response relationship, where progressively increasing cognitive load produces graded deterioration in motor performance. Furthermore, while overall gait and mobility outcomes have been widely investigated, there is a lack of detailed evidence regarding how cognitive load influences specific phases of functional mobility tasks, such as sit-to-stand, gait, turning, and stand-to-sit transitions. Previous studies suggest that different movement phases may vary in their sensitivity to cognitive interference due to differences in biomechanical and postural control demands. However, this phasespecific behavior remains underexplored, particularly in the context of graded cognitive loading.
Therefore, there is a clear gap in the literature regarding the combined effect of graded cognitive load and phase-specific motor behavior during functional mobility tasks.
Studietype
Inschrijving (Geschat)
Fase
- Niet toepasbaar
Contacten en locaties
Studiecontact
- Naam: mostafa seliem, master
- Telefoonnummer: 01554049062
- E-mail: mostafasleim92@gmail.com
Deelname Criteria
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
- Volwassen
- Oudere volwassene
Accepteert gezonde vrijwilligers
Beschrijving
Inclusion Criteria:
- Age ≥ 60 years
- Ability to ambulate independently without assistive devices
- Ability to follow verbal instructions and perform dual-task activities
- Medically stable and capable of participating in functional mobility assessment Cognitive function within normal range, defined as Mini-Mental State Examination (MMSE) score ≥ 24 out of 30, indicating absence of significant cognitive impairment .
- Functionqal independence in basic activities of daily living, defined as Barthel Index score ≥ 90 out of 100
- Body Mass Index (BMI) between 18.5 and 29.9 kg/m², as values ≥ 30 kg/m² (obesity) may adversely affect gait and balance performance.
Exclusion Criteria:
- Any neurological disease that affects walking or balance, such as stroke or Parkinson's disease
- Any musculoskeletal condition that limits lower-limb movement or affects normal walking patterns
- Severe cognitive impairment defined as Mini-Mental State Examination (MMSE) score < 24
- Visual, vestibular, or hearing problems that affect safe walking or balance control
- History of lower-limb injury or surgery within the last 6 months
- Serious medical conditions that make participation unsafe, such as unstable cardiac or respiratory disease
Studie plan
Hoe is de studie opgezet?
Ontwerpdetails
- Primair doel: Behandeling
- Toewijzing: NVT
- Interventioneel model: Opdracht voor een enkele groep
- Masker: Geen (open label)
Wapens en interventies
Deelnemersgroep / Arm |
Interventie / Behandeling |
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Experimenteel: Dual-Task Cognitive Loading Protocol
sixty Participants will perform the time-up-and-go test under four standardized experimental conditions designed to investigate the dose-response and phase-specific effects of graded cognitive load on functional mobility in older adults.
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Participants will perform the TUG test under four standardized experimental conditions: 1. Single-Task Condition (Baseline) : Participants will perform TUG test without any additional cognitive task. 2-Low Cognitive Load Condition:Participants will perform the TUG test while simultaneously performing simple backward counting by ones starting from a randomly assigned number between 90 and 100. 3-Moderate Cognitive Load Condition :Participants will perform the TUG test while simultaneously performing serial backward counting by threes starting from a randomly assigned number between 90 and 100. 4-High Cognitive Load Condition:Participants will perform the TUG test while simultaneously performing serial subtraction by sevens (Serial 7s task) starting from a randomly assigned number between 90 and 100. |
Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
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Timed Up and Go (TUG) Completion Time
Tijdsspanne: up to one day
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A smartwatch will be used to assess the completion time of the TUG test.
The total time required to complete the TUG test under each cognitive load condition will be recorded in seconds and used as the primary measure of functional mobility performance.
Increased TUG completion time will indicate deterioration in functional mobility under cognitive interference conditions
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up to one day
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Secundaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
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sit-to-stand phase time
Tijdsspanne: up to one day
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A smartwatch will be used to assess the time of sit-to-stand phase as a part of the TUG test
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up to one day
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walking phase time
Tijdsspanne: up to one day
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The smartwatch will be used to assess the time of the walking phase as a part of TUG test
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up to one day
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turning phase time
Tijdsspanne: up to one day
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The smartwatch will be used to assess the time of the turning phase as a part of TUG test
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up to one day
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stand-to-sit phase
Tijdsspanne: up to one day
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The smartwatch will be used to assess the time of the stand-to-sit phase as a part of TUG tes
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up to one day
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gait speed
Tijdsspanne: up to one day
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A sagittal-plane video-based kinematic analysis system will be used to evaluate gait speed.ormal
gait speed for healthy adults generally ranges from 1.2 to 1.4 meters per second (m/s)
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up to one day
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step length
Tijdsspanne: up to one day
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A sagittal-plane video-based kinematic analysis system will be used to evaluate step length.
The normal walking step length is about 2.5 feet (75 to 79 cm) for men and 2.2 feet (66 to 69 cm) for women
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up to one day
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cadence
Tijdsspanne: up to one day
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A sagittal-plane video-based kinematic analysis system will be used to evaluate cadence.
A normal comfortable walking cadence for healthy adults generally ranges from 100 to 120 steps per minute
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up to one day
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step time
Tijdsspanne: up to one day
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A sagittal-plane video-based kinematic analysis system will be used to evaluate step time.
the normal step time for a healthy adult walking at a comfortable, self-selected speed is approximately 0.5 seconds per single step
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up to one day
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turning duration
Tijdsspanne: up to one day
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A sagittal-plane video-based kinematic analysis system will be used to evaluate turning duration.For healthy, normal adults, the average turning durations typically fall into these ranges from 1.4 to 1.5 seconds
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up to one day
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peak trunk flexion angle
Tijdsspanne: up to one day
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sagittal-plane video-based kinematic analysis system will be used to evaluate peak trunk flexion.Studies show that actively flexing the trunk increases peak angles (reaching higher ranges like an added 47° in intentional flexed landings vs. preferred landings) which helps absorb impact and protect the knees
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up to one day
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peak hip flexion angle
Tijdsspanne: up to one day
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the sagittal-plane video-based kinematic analysis system will be used to evaluate peak hip flexion angle.
it should be from 130-140 degree.
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up to one day
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peak knee flexion angle
Tijdsspanne: up to one day
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The sagittal-plane video-based kinematic analysis system will be used to evaluate peak knee flexion angle.
it should be from 120-150 degree.
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up to one day
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Medewerkers en onderzoekers
Sponsor
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Meer informatie
Termen gerelateerd aan deze studie
Trefwoorden
Andere studie-ID-nummers
- P.T.REC/012/006633
Informatie over medicijnen en apparaten, studiedocumenten
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