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A Comparsion Between Articaine Hydrochloride and Buffered Lidocaine Hydrochloride in the Context of Maxillary Permanent Teeth Extraction Using the Buccal Infiltration Technique Only(Clinical Study).

2026년 5월 15일 업데이트: Tishreen University

palatal anesthesia remains one of the greatest fears of patients as well as being painful for the patient and bothersome for the dentist .Research is still ongoing to find the best anesthetic agent that achieves the highest success rate of anesthesia and pain control without the need for palatal injection.

2% Lidocaine with sodium bicarbonate the best agent that can achieve the highest success rate across all criteria when using the buccal infiltration technique without the need for palatal anesthesia? The importance of this research lies in finding the best agent that may eliminate the need for painful and annoying palatal injection, therapy alleviating many patient fears, achieving greater patient cooperation during dental procedures in the maxilla, and avoiding multiple palatal anesthesia failures.

This research aim to compare the anesthetic efficacy between 4% Articaine and 2% Lidocaine with sodium bicarbonate using the buccal infiltration technique without palatal anesthesia in the context of permanent maxillary first molar extraction, in terms of:

  1. Onset time of anesthesia
  2. Pain during injection
  3. Anesthetic efficacy
  4. Duration of anesthetic action The study will be conducted on a sample of patients attending the anesthesia and extraction clinics at the faculty of dentistry, University of Latakia, and the minor oral surgery and dental impaction clinic at Latakia University Hospital. The sample consists of 50 patients with symmetrical upper teeth that are worn down and require extraction.

Inclusion Criteria:

  1. Systemically healthy patients
  2. Patiens age between 18-60 years
  3. Patients with no allergy to amide local anesthetics
  4. Patients requiring extraction of fully erupted, permanent, single-root teeth Exclusion Criteria

1.Patients younger than 18 years 2.Patients who have taken any analgesic, sedative, antihistamine, anxiolytic, or beta-blocker medications (as the affect anesthetic efficacy assessment) 3.Patiens with sickle cell anemia 4.Patiens allergic to amid local anesthetics

The material and devices used in the study include:

Examination instruments: Forceps, mirror, probe. Local antiseptics: Sterile gauze- 0.12% chlorhexidine mouthwash.

Anesthesia instruments and materials:

  1. Topical anesthetic : Lidocaine 2% with vasoconstrictor epinephrine 1:80,000-cartridge volume 1.8 ml
  2. Local anesthetic: Articaine 4% with vasoconstrictor epinephrine 1:100,000-cartridge volume 1.8 ml
  3. Vial of sodium bicarbonate 8.4%- volume 10 ml , 1 ml insulin syringe, and 3 ml syringe
  4. Dental anesthetic syringe (Rowe type)-shoort needle, length 25 mm, diameter 27 gauge.

Technique

  • Symmetrical anxiety in patients will be divided into two sessions, preferably at least one week apart.
  • Before anesthesia, the heft-parker visual analog scale will be presented, and the patient will be taught how to choose the independent value according to degree of pain or discomfort they experience.

.In the first session, one of the two teeth will be selected using examples of intracanal reamers with internal engagement. The actual times corresponding to the internal statements of the slowly managed staff should be recorded without changing the lack of search. Then, time is calculated from the completion of the anesthetic solution deposition until the depth of anesthesia is confirmed using a sharp instrument with slight pressure at the tooth junction from the palatal side. The depth of anesthesia is assessed using the VAS project then the extraction is done.

If sufficient anesthetic depth is not achieved for each tooth, a palatal approach is added, and the case is considered excessive.

In the second session, 0.2 ml of mepivacaine is emptied and replace with 0.2ml of sodium bicarbonate. The dose is selected according to the depth of internal statements corresponding to the tooth to be treated. In the case of a normal plan, anesthesia is performed with a lack of search, and then time is calculated from the completion of the anesthetic solution deposition until the depth of anesthesia is confirmed using a sharp instrument with slight pressure at the tooth junction from the palatal side.

The depth of anesthesia is assessed using the VAS project then the extraction is done.

If sufficient anesthetic depth is not achieved for each tooth, a palatal approach is added, and the case considered excessive.

연구 개요

연구 유형

중재적

등록 (실제)

50

단계

  • 해당 없음

연락처 및 위치

이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.

연구 장소

      • Latakia, 시리아
        • Latakia university

참여기준

연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.

자격 기준

공부할 수 있는 나이

  • 성인

건강한 자원 봉사자를 받아들입니다

설명

Inclusion Criteria:

  • Inclusion Criteria:

    1. Systemically healthy patients
    2. Patiens age between 18-60 years
    3. Patients with no allergy to amide local anesthetics
    4. Patients requiring extraction of fully erupted, permanent, single-root teeth Exclusion Criteria
    1. Patients younger than 18 years
    2. Patients who have taken any analgesic, sedative, antihistamine, anxiolytic, or beta-blocker medications (as the affect anesthetic efficacy assessment)
    3. Patients with sickle cell anemia
    4. Patiens allergic to amid local anesthetics

      Exclusion Criteria:

공부 계획

이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.

연구는 어떻게 설계됩니까?

디자인 세부사항

  • 주 목적: 치료
  • 할당: 해당 없음
  • 중재 모델: 단일 그룹 할당
  • 마스킹: 없음(오픈 라벨)

무기와 개입

참가자 그룹 / 팔
개입 / 치료
실험적: A Comparsion Between Articaine Hydrochloride and Buffered Lidocaine Hydrochloride in the Context of

The study will be conducted on a sample of patients attending the anesthesia and extraction clinics at the faculty of dentistry, University of Latakia, and the minor oral surgery and dental impaction clinic at Latakia University Hospital. The sample consists of 50 patients with symmetrical upper teeth that are worn down and require extraction.

Inclusion Criteria:

  1. Systemically healthy patients
  2. Patiens age between 18-60 years
  3. Patients with no allergy to amide local anesthetics
  4. Patients requiring extraction of fully erupted, permanent, single-root teeth Exclusion Criteria

1.Patients younger than 18 years 2.Patients who have taken any analgesic, sedative, antihistamine, anxiolytic, or beta-blocker medications (as the affect anesthetic efficacy assessment) 3.Patiens with sickle cell anemia 4.Patiens allergic to amid local anesthetics

The material and devices used in the study include:

Examination instruments: Forceps, mirror, probe. Local antiseptics: Sterile gauze- 0.12% chlo

연구는 무엇을 측정합니까?

주요 결과 측정

결과 측정
측정값 설명
기간
The Visual Analogue Scale (VAS)
기간: Time Frame: The follow-up begins from the start of anesthesia until its effect wears off after extraction. immediately after the intervention/procedure/surgery"

The Visual Analogue Scale (VAS) was used as the main scale to express the degree of pain.

Description: Studied Variables 1.Pain at two surgical sites(the two fields) 2.Onset time of anesthetic effect 3.Anesthetic efficacy (by using a sharp needle inserted into the palatal gingiva to a certain depth) 4.Duration of anesthetic action(source: E-kholey 2016)

Time Frame: The follow-up begins from the start of anesthesia until its effect wears off after extraction. immediately after the intervention/procedure/surgery"
The Visual Analogue Scale (VAS) was used as the main scale to express the degree of pain.
기간: The follow-up begins from the start of anesthesia until its effect wears off after extraction. immediately after the intervention/procedure/surgery"

Studied Variables

  1. Pain at two surgical sites(the two fields)
  2. Onset time of anesthetic effect
  3. Anesthetic efficacy (by using a sharp needle inserted into the palatal gingiva to a certain depth)
  4. Duration of anesthetic action(source: E-kholey 2016)
The follow-up begins from the start of anesthesia until its effect wears off after extraction. immediately after the intervention/procedure/surgery"

공동 작업자 및 조사자

여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.

수사관

  • 연구 의자: Ahmad Ahmad, Professor, lattakia university

연구 기록 날짜

이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.

연구 주요 날짜

연구 시작 (실제)

2025년 7월 15일

기본 완료 (추정된)

2027년 2월 15일

연구 완료 (추정된)

2027년 2월 20일

연구 등록 날짜

최초 제출

2026년 4월 27일

QC 기준을 충족하는 최초 제출

2026년 5월 15일

처음 게시됨 (실제)

2026년 5월 19일

연구 기록 업데이트

마지막 업데이트 게시됨 (실제)

2026년 5월 19일

QC 기준을 충족하는 마지막 업데이트 제출

2026년 5월 15일

마지막으로 확인됨

2026년 4월 1일

추가 정보

이 연구와 관련된 용어

기타 연구 ID 번호

  • Tishreen-U O,M Facial surgery

개별 참가자 데이터(IPD) 계획

개별 참가자 데이터(IPD)를 공유할 계획입니까?

아니요

약물 및 장치 정보, 연구 문서

미국 FDA 규제 의약품 연구

아니

미국 FDA 규제 기기 제품 연구

아니

이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .

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