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A Comparsion Between Articaine Hydrochloride and Buffered Lidocaine Hydrochloride in the Context of Maxillary Permanent Teeth Extraction Using the Buccal Infiltration Technique Only(Clinical Study).

15 maggio 2026 aggiornato da: Tishreen University

palatal anesthesia remains one of the greatest fears of patients as well as being painful for the patient and bothersome for the dentist .Research is still ongoing to find the best anesthetic agent that achieves the highest success rate of anesthesia and pain control without the need for palatal injection.

2% Lidocaine with sodium bicarbonate the best agent that can achieve the highest success rate across all criteria when using the buccal infiltration technique without the need for palatal anesthesia? The importance of this research lies in finding the best agent that may eliminate the need for painful and annoying palatal injection, therapy alleviating many patient fears, achieving greater patient cooperation during dental procedures in the maxilla, and avoiding multiple palatal anesthesia failures.

This research aim to compare the anesthetic efficacy between 4% Articaine and 2% Lidocaine with sodium bicarbonate using the buccal infiltration technique without palatal anesthesia in the context of permanent maxillary first molar extraction, in terms of:

  1. Onset time of anesthesia
  2. Pain during injection
  3. Anesthetic efficacy
  4. Duration of anesthetic action The study will be conducted on a sample of patients attending the anesthesia and extraction clinics at the faculty of dentistry, University of Latakia, and the minor oral surgery and dental impaction clinic at Latakia University Hospital. The sample consists of 50 patients with symmetrical upper teeth that are worn down and require extraction.

Inclusion Criteria:

  1. Systemically healthy patients
  2. Patiens age between 18-60 years
  3. Patients with no allergy to amide local anesthetics
  4. Patients requiring extraction of fully erupted, permanent, single-root teeth Exclusion Criteria

1.Patients younger than 18 years 2.Patients who have taken any analgesic, sedative, antihistamine, anxiolytic, or beta-blocker medications (as the affect anesthetic efficacy assessment) 3.Patiens with sickle cell anemia 4.Patiens allergic to amid local anesthetics

The material and devices used in the study include:

Examination instruments: Forceps, mirror, probe. Local antiseptics: Sterile gauze- 0.12% chlorhexidine mouthwash.

Anesthesia instruments and materials:

  1. Topical anesthetic : Lidocaine 2% with vasoconstrictor epinephrine 1:80,000-cartridge volume 1.8 ml
  2. Local anesthetic: Articaine 4% with vasoconstrictor epinephrine 1:100,000-cartridge volume 1.8 ml
  3. Vial of sodium bicarbonate 8.4%- volume 10 ml , 1 ml insulin syringe, and 3 ml syringe
  4. Dental anesthetic syringe (Rowe type)-shoort needle, length 25 mm, diameter 27 gauge.

Technique

  • Symmetrical anxiety in patients will be divided into two sessions, preferably at least one week apart.
  • Before anesthesia, the heft-parker visual analog scale will be presented, and the patient will be taught how to choose the independent value according to degree of pain or discomfort they experience.

.In the first session, one of the two teeth will be selected using examples of intracanal reamers with internal engagement. The actual times corresponding to the internal statements of the slowly managed staff should be recorded without changing the lack of search. Then, time is calculated from the completion of the anesthetic solution deposition until the depth of anesthesia is confirmed using a sharp instrument with slight pressure at the tooth junction from the palatal side. The depth of anesthesia is assessed using the VAS project then the extraction is done.

If sufficient anesthetic depth is not achieved for each tooth, a palatal approach is added, and the case is considered excessive.

In the second session, 0.2 ml of mepivacaine is emptied and replace with 0.2ml of sodium bicarbonate. The dose is selected according to the depth of internal statements corresponding to the tooth to be treated. In the case of a normal plan, anesthesia is performed with a lack of search, and then time is calculated from the completion of the anesthetic solution deposition until the depth of anesthesia is confirmed using a sharp instrument with slight pressure at the tooth junction from the palatal side.

The depth of anesthesia is assessed using the VAS project then the extraction is done.

If sufficient anesthetic depth is not achieved for each tooth, a palatal approach is added, and the case considered excessive.

Panoramica dello studio

Tipo di studio

Interventistico

Iscrizione (Effettivo)

50

Fase

  • Non applicabile

Contatti e Sedi

Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.

Luoghi di studio

      • Latakia, Siria
        • Latakia university

Criteri di partecipazione

I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.

Criteri di ammissibilità

Età idonea allo studio

  • Adulto

Accetta volontari sani

Descrizione

Inclusion Criteria:

  • Inclusion Criteria:

    1. Systemically healthy patients
    2. Patiens age between 18-60 years
    3. Patients with no allergy to amide local anesthetics
    4. Patients requiring extraction of fully erupted, permanent, single-root teeth Exclusion Criteria
    1. Patients younger than 18 years
    2. Patients who have taken any analgesic, sedative, antihistamine, anxiolytic, or beta-blocker medications (as the affect anesthetic efficacy assessment)
    3. Patients with sickle cell anemia
    4. Patiens allergic to amid local anesthetics

      Exclusion Criteria:

Piano di studio

Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.

Come è strutturato lo studio?

Dettagli di progettazione

  • Scopo principale: Trattamento
  • Assegnazione: N / A
  • Modello interventistico: Assegnazione di gruppo singolo
  • Mascheramento: Nessuno (etichetta aperta)

Armi e interventi

Gruppo di partecipanti / Arm
Intervento / Trattamento
Sperimentale: A Comparsion Between Articaine Hydrochloride and Buffered Lidocaine Hydrochloride in the Context of

The study will be conducted on a sample of patients attending the anesthesia and extraction clinics at the faculty of dentistry, University of Latakia, and the minor oral surgery and dental impaction clinic at Latakia University Hospital. The sample consists of 50 patients with symmetrical upper teeth that are worn down and require extraction.

Inclusion Criteria:

  1. Systemically healthy patients
  2. Patiens age between 18-60 years
  3. Patients with no allergy to amide local anesthetics
  4. Patients requiring extraction of fully erupted, permanent, single-root teeth Exclusion Criteria

1.Patients younger than 18 years 2.Patients who have taken any analgesic, sedative, antihistamine, anxiolytic, or beta-blocker medications (as the affect anesthetic efficacy assessment) 3.Patiens with sickle cell anemia 4.Patiens allergic to amid local anesthetics

The material and devices used in the study include:

Examination instruments: Forceps, mirror, probe. Local antiseptics: Sterile gauze- 0.12% chlo

Cosa sta misurando lo studio?

Misure di risultato primarie

Misura del risultato
Misura Descrizione
Lasso di tempo
The Visual Analogue Scale (VAS)
Lasso di tempo: Time Frame: The follow-up begins from the start of anesthesia until its effect wears off after extraction. immediately after the intervention/procedure/surgery"

The Visual Analogue Scale (VAS) was used as the main scale to express the degree of pain.

Description: Studied Variables 1.Pain at two surgical sites(the two fields) 2.Onset time of anesthetic effect 3.Anesthetic efficacy (by using a sharp needle inserted into the palatal gingiva to a certain depth) 4.Duration of anesthetic action(source: E-kholey 2016)

Time Frame: The follow-up begins from the start of anesthesia until its effect wears off after extraction. immediately after the intervention/procedure/surgery"
The Visual Analogue Scale (VAS) was used as the main scale to express the degree of pain.
Lasso di tempo: The follow-up begins from the start of anesthesia until its effect wears off after extraction. immediately after the intervention/procedure/surgery"

Studied Variables

  1. Pain at two surgical sites(the two fields)
  2. Onset time of anesthetic effect
  3. Anesthetic efficacy (by using a sharp needle inserted into the palatal gingiva to a certain depth)
  4. Duration of anesthetic action(source: E-kholey 2016)
The follow-up begins from the start of anesthesia until its effect wears off after extraction. immediately after the intervention/procedure/surgery"

Collaboratori e investigatori

Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.

Investigatori

  • Cattedra di studio: Ahmad Ahmad, Professor, lattakia university

Studiare le date dei record

Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.

Studia le date principali

Inizio studio (Effettivo)

15 luglio 2025

Completamento primario (Stimato)

15 febbraio 2027

Completamento dello studio (Stimato)

20 febbraio 2027

Date di iscrizione allo studio

Primo inviato

27 aprile 2026

Primo inviato che soddisfa i criteri di controllo qualità

15 maggio 2026

Primo Inserito (Effettivo)

19 maggio 2026

Aggiornamenti dei record di studio

Ultimo aggiornamento pubblicato (Effettivo)

19 maggio 2026

Ultimo aggiornamento inviato che soddisfa i criteri QC

15 maggio 2026

Ultimo verificato

1 aprile 2026

Maggiori informazioni

Termini relativi a questo studio

Altri numeri di identificazione dello studio

  • Tishreen-U O,M Facial surgery

Piano per i dati dei singoli partecipanti (IPD)

Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?

NO

Informazioni su farmaci e dispositivi, documenti di studio

Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti

No

Studia un dispositivo regolamentato dalla FDA degli Stati Uniti

No

Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .

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