Contribution of Corticospinal and Reticulospinal Mechanisms to Neural Adaptations Induced by Muscle Strengthening of Healthy Adults (RenfoRS)
This controlled trial aims to investigate the neural adaptations induced by a 4-week resistance training program targeting the triceps surae muscles. Specifically, the study will examine the contribution of the corticospinal and reticulospinal pathways to the nervous adaptations associated with resistance training. It will give us more information about the nervous pathways mediating adaptations following this type of training. The main question it aims to answer is: What is the contribution of the cortico- and reticulospinal tracts to the nervous adaptations following a resistance training program?
Participants will take part to a resistance training program of the triceps surae for 4 weeks. They will undergo assessments of corticospinal and reticulospinal excitability before and after the training intervention to determine changes in neural pathways
The findings will improve our understanding of the neural mechanisms underlying strength gains following resistance training.
연구 개요
연구 유형
등록 (추정된)
단계
- 해당 없음
참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion Criteria:
- Male or female participants aged 18 to 40 years
- Willing and able to provide written informed consent
- No regular participation (>1 session per week) in resistance training aimed at increasing maximal strength
- Affiliated with, or beneficiary of, a social security system
Exclusion Criteria:
- Personal or family history of epilepsy
- Conditions associated with a significantly reduced seizure threshold, including sleep deprivation, extreme fatigue, or jet lag
- Use of medications or substances known to lower the seizure threshold
- Use of medications that may influence neurophysiological measures (e.g., neuroleptics, anxiolytics, antidepressants, anticonvulsants)
- Presence of cardiac pacemakers or other implanted devices that may interfere with magnetic fields
- Presence of metallic implants (mechanical or electronic), including cochlear implants, cranial implants, cardiac or neural stimulators, drug infusion pumps, magnetic aneurysm clips, or cerebrospinal fluid shunts
- Presence of non-removable metallic objects
- Presence of intraocular or intracranial metallic foreign bodies
- Known hearing disorders (e.g., tinnitus)
- History of psychiatric or neurological disorders
- Presence of severe cardiac or respiratory disease
- History of severe traumatic brain injury with loss of consciousness
- History of brain lesions of vascular, tumoral, infectious, or metabolic origin (e.g., stroke)
- History or presence of bleeding disorders (e.g., venous or arterial thrombosis, thrombophlebitis)
- Individuals currently under an exclusion period from another research study
- Individuals listed under Articles L.1121-5 to L.1121-8 and L.1121-12 of the French Public Health Code, including:
- Pregnant, parturient, or breastfeeding women
- Women of childbearing potential not using effective contraception
- Individuals deprived of liberty by judicial or administrative decision
- Adults under legal protection (guardianship, curatorship, or legal safeguard) or unable to provide consent and not under such protection
- Minors
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 기초 과학
- 할당: 해당 없음
- 중재 모델: 단일 그룹 할당
- 마스킹: 없음(오픈 라벨)
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
|---|---|
|
실험적: 저항 훈련 그룹
|
Participants will complete a 4-week resistance training program targeting the triceps sure muscles (3 sessions per week). |
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
the change in maximum force achieved during a maximal voluntary contraction (MVC) of plantar flexion (the primary action of the triceps surae muscles).
기간: At baseline (before the first exercise session) and immediately after completion of the exercise sessions
|
The maximum force, achieved during a maximal voluntary contraction (MVC), will be recorded using an isokinetic ergometer (Biodex Medical Systems Inc., Shirley, NY, USA). |
At baseline (before the first exercise session) and immediately after completion of the exercise sessions
|
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
The changes in the amplitude of electrophysiological responses evoked by magnetic or electrical stimulation at different levels of the neuromuscular system (cortical, thoracic, peripheral nerve).
기간: During intervention
|
Electrophysiological responses will be recorded using surface electromyography (sEMG), with electromyography electrodes (Contrôle Graphique Medical, Brie-Compte-Robert, France) placed on the muscle surface of the muscles under study. The following techniques will be used to elicit these responses, whether or not they are conditioned by auditory stimulation: intense auditory stimulation at 115 dB (SSI) coupled with a visual stimulus (i.e., the illumination of a red light-emitting diode, LED); non-intense auditory stimulation at 70 dB (SS) coupled with the illumination of a red LED; the illumination of the red LED without any sound stimulation (V). |
During intervention
|
공동 작업자 및 조사자
연구 기록 날짜
연구 주요 날짜
연구 시작 (추정된)
기본 완료 (추정된)
연구 완료 (추정된)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
추가 관련 MeSH 약관
기타 연구 ID 번호
- C25-84
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
약물 및 장치 정보, 연구 문서
미국 FDA 규제 의약품 연구
미국 FDA 규제 기기 제품 연구
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