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Safety and Efficacy Comparison Between CHF5993 100/6 12.5µg pMDI to Seretide Evohaler 125/25µg pMDI in Adolescent Subjects With Asthma (TRIADES)

2026년 10월 2일 업데이트: Chiesi Farmaceutici S.p.A.

A 52-Week, Randomised, Double-Blind, Double-Dummy, Multinational, Multicenter, Active-Controlled, 2-Arm Parallel Group Study Comparing CHF5993 100/6/12.5 μg pMDI (Fixed Combination of Extrafine Beclomethasone Dipropionate Plus Formoterol Fumarate Plus Glycopyrronium Bromide) to Seretide® Evohaler® 125/25 μg pMDI (Fixed Combination of Fluticasone Propionate/Salmeterol Xinafoate) in Adolescent Subjects With Uncontrolled Asthma on Medium Doses of Inhaled Corticosteroids in Combination With Long-Acting β2-Agonists

The CLI-05993AA5-06 study is an interventional study designed to investigate the safety and efficacy of a new experimental drug called CHF5993 pMDI compared to the currently approved Seretide 125 Evohaler pMDI in adolescent patients with uncontrolled asthma.

연구 개요

상태

아직 모집하지 않음

정황

개입 / 치료

상세 설명

Outpatients attending the hospital clinics/study centers will be recruited. Uncontrolled asthma adolescent subjects will be recruited. A total of 420 subjects will be randomized. The whole study will last approximately 52 weeks for each subject.

연구 유형

중재적

등록 (추정된)

700

단계

  • 3단계

연락처 및 위치

이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.

연구 연락처

연구 장소

  • 독일
      • Frankfurt, 독일
        • Institute for Respiratory Diseases Medaimun GmbH
        • 연락하다:
          • Stefan Zielen
      • Göttingen, 독일
        • Georg-August-Universität Göttingen
        • 연락하다:
          • Christiane Lex
      • Jena, 독일
        • Universitätsklinikum Jena
        • 연락하다:
          • Michael Lorenz
      • Stuttgart, 독일
        • Centre for Congenital Heart Defects Stuttgart, Paediatric Intensive Care, Pulmonology and Allergology
        • 연락하다:
          • Marcus Rose
  • 스페인
      • Badalona, 스페인
        • Hospital Universitario Germans Trias
        • 연락하다:
          • Albert Roger Reig
      • Barcelona, 스페인
        • Vall d'Hebron University Hospital
        • 연락하다:
          • Teresa Garriga-Baraut
      • Barcelona, 스페인
        • Hospital Sant Joan de Deu
        • 연락하다:
          • Jaime Lozano Blasco
      • Cartagena, 스페인
        • Hospital General Universitario Santa Lucia
        • 연락하다:
          • Jose Valverde Molina
      • Jerez de la Frontera, 스페인
        • Hospital Universitario De Jerez Servicio de Pediatría
        • 연락하다:
          • David Gomez Pastrana
      • Madrid, 스페인
        • Hospital Universitario Infanta Leonor
        • 연락하다:
          • Maria Vazquez de la Torre Gaspar
      • Madrid, 스페인
        • Hospital Universitario Severo Ochoa
        • 연락하다:
          • Sergio Quevedo Teruel
      • Santiago de Compostela, 스페인
        • Hospital Clínico Universitario de Santiago de Compostela
        • 연락하다:
          • Carlos Garcia Magan
      • Valencia, 스페인
        • IMED Valencia
        • 연락하다:
          • Noelia Colomer Hernadez
  • 이탈리아
      • Brescia, 이탈리아
        • ASST Spedali Civili Brescia
        • 연락하다:
          • Laura Pini
      • Brindisi, 이탈리아
        • "A. Perrino" Hospital
        • 연락하다:
          • Aniello Meoli
      • Genoa, 이탈리아
        • Istituto Giannina Gaslini Pediatric Allergic Center,
        • 연락하다:
          • Maria Angela Tosca
      • Messina, 이탈리아
        • University of Messina G. Martino Hospital, Allergy and Clinical Immunology Unit
        • 연락하다:
          • Luisa Riccardi
      • Milan, 이탈리아
        • Buzzi Children Hospital
        • 연락하다:
          • Michele Ghezzi
      • Naples, 이탈리아
        • Federico II University, Department of Translational Medical Sciences, Section of Pediatrics
        • 연락하다:
          • Melissa Borrelli
      • Naples, 이탈리아
        • IPAS (Respiratory Diseases of Pediatric Interest) University of Campania 'Luigi Vanvitelli',
        • 연락하다:
          • Michele Miraglia del Giudice
      • Parma, 이탈리아
        • University Hospital of Parma
        • 연락하다:
          • Susanna Maria Roberta Esposito
      • Pisa, 이탈리아
        • University Hospital of Pisa, Pediatrics Unit
        • 연락하다:
          • Maria Elisa di Cicco
      • Roma, 이탈리아
        • Fondazione Policlinico Universitario A. Gemelli IRCCS, Department of Woman and Child Health and Public Health
        • 연락하다:
          • Roberta Onesimo
      • Rome, 이탈리아
        • Bambino Gesù Pediatric Hospital IRCCS, Allergy Division
        • 연락하다:
          • Alessandro Fiocchi
      • Rozzano, 이탈리아
        • IRCCS Humanitas Research Hospital
        • 연락하다:
          • Enrico Heffler

참여기준

연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.

자격 기준

공부할 수 있는 나이

12년 (어린이)

건강한 자원 봉사자를 받아들입니다

아니

연구 대상 성별

모두

설명

Inclusion Criteria:

  • Subject's written informed consent obtained prior to any study related procedure;
  • Male and female adolescent aged ≥ 12 and <18 years;
  • Subject participating in the Pharmacokinetic(s) (PK) part of the study, body weight should be ≥ 30kg
  • A documented history of asthma for at least 6 months
  • Subjects in treatment with double therapy with medium doses of inhaled corticosteroids (ICS) in fixed or free combination with a long-acting β2-agonist (LABA) ( > 500-1000 μg daily dose Beclomethasone Dipropionate non-extrafine or estimated clinically comparable dose plus formoterol 24 µg/day or salmeterol 100 µg/day or vilanterol 25 µg/day) at a stable dose for at least 4 weeks prior to screening;
  • Subjects must have a cooperative attitude and the ability to be trained to use correctly the pMDI inhalers and e-Diary, to be able to read/write, to be able to perform the required outcomes measurements (e.g., technically acceptable spirometry, e-Diary completion) and the ability to understand the risks involved.
  • Subjects with a pre-Bronchodilator (BD) Forced Expiratory Volume in the first second (FEV1) ≤90% and ≥60% of their predicted normal value, after appropriate washout from BDs, at the Screening and Randomization Visits
  • Subjects with a positive response to a reversibility test at screening, defined as FEV1 ≥12% and ≥200 mL over baseline, 10 to 15 minutes (min) after inhaling 200-400 µg of salbutamol pMDI.
  • Subjects with uncontrolled asthma evidenced by an ACQ-7 total score ≥1.5 at screening;
  • A documented history of one or more asthma exacerbations requiring treatment with systemic corticosteroids (SCS) or emergency department visit or in-patient hospitalization in the previous 12 months;

Exclusion Criteria:

  • History of "at risk" asthma: history of near fatal asthma or of a past hospitalization for asthma in an intensive care unit which, in the judgement of the Investigator, may place the subject at undue risk;
  • Recent exacerbation or respiratory tract infection: hospitalization, emergency room admission or use of SCS for an asthma exacerbation or a documented diagnosis of lower respiratory tract infection that required antibiotics or an unresolved respiratory tract infection within 4 weeks prior to Screening Visit (V1) or during the run-in period;
  • Respiratory disorders other than asthma: this can include but is not limited to: α1-antitrypsin deficiency, active tuberculosis, bronchiectasis, cystic fibrosis, sarcoidosis, pulmonary hypertension and interstitial lung disease;
  • Current smokers (including e-cigarettes, vaping and hookah), or ex-smokers with a smoking history of ≥5 pack-years (pack-years = the number of cigarette packs per day times the number of years), or current use of inhaled or oral cannabis products. Ex-smokers must have stopped smoking ≥1 year (≥6 months for e-cigarettes);
  • Other severe acute or chronic medical (such as but not limited to thyrotoxicosis, diabetes mellitus, and untreated hypokalemia) or malignancy or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or study treatment administration or may interfere with the interpretation of study results and, in the judgment of the Investigator, would make the subject inappropriate for entry into this study;
  • Any change in dose, schedule or formulation of the combination ICS plus LABA in the 4 weeks prior to Screening Visit (V1)
  • Subjects using SCS medication in the 4 weeks or slow-release corticosteroids in the 12 weeks, prior to screening
  • Only for subjects included in the subset for PK assessment:

Veins unsuitable for repeated venipuncture; Blood donation or blood loss (>450 mL) in the 4 weeks before randomization.

공부 계획

이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.

연구는 어떻게 설계됩니까?

디자인 세부사항

  • 주 목적: 치료
  • 할당: 무작위
  • 중재 모델: 병렬 할당
  • 마스킹: 네 배로

무기와 개입

참가자 그룹 / 팔
개입 / 치료
실험적: Inhaler CHF5993 100/6/12,5μg pMDI
의약품: CHF5993 100/6/12.5 μg pMDI HFA-152a

Drug: CHF5993 100/6/12.5 μg pMDI HFA-152a administered via Pressurized Metered Dose Inhaler (pMDI).

Active ingredients: Beclomethasone Dipropionate (BDP)//Formoterol Fumarate (FF) /Glycopyrronium Bromide (GB) 100/6/12,5μg per actuation; Excipients: HFA-152a propellant.
활성 비교기: Seretide Evohaler FP/SLM pMDI 125/25μg
의약품: Seretide Evohaler

Drug: Seretide Evohaler administered via Pressurized Metered Dose Inhaler (pMDI).

Active ingredients: Fluticasone Propionate (FP)/Salmeterol Xinafoate (SLM) pMDI 125/25μg per actuation; Excipients: HFA-134a propellant.

연구는 무엇을 측정합니까?

주요 결과 측정

결과 측정
측정값 설명
기간
Change from baseline in pre-dose Forced Expiratory Volume FEV1 in the first second (FEV1).
기간: Baseline (pre-dose on Week 0) and Week 26

Population summary measure is the adjusted mean between treatment difference comparing CHF5993 BDP/FF/GB pMDI vs. Seretide® Evohaler® FP/SLM pMDI in a Intent To Treat (ITT) Population to demonstrate the superiority of CHF5993 BDP/FF/GB pMDI compared to Seretide Evohaler FP/SLM pMDI
Baseline (pre-dose on Week 0) and Week 26

2차 결과 측정

결과 측정
측정값 설명
기간
Change from baseline in 2h post-dose FEV1
기간: Baseline (pre-dose on Week 0) and Week 26

Population summary measure is the adjusted mean between treatment difference comparing CHF5993 BDP/FF/GB pMDI vs. Seretide® Evohaler® FP/SLM pMDI in ITT population to demonstrate the superiority of CHF5993 BDP/FF/GB pMDI compared to Seretide Evohaler FP/SLM pMDI
Baseline (pre-dose on Week 0) and Week 26
Evaluation of Severe asthma exacerbations rate over the 52 weeks of treatment
기간: Over the 52 weeks of treatment
Over the 52 weeks of treatment
Time to first severe exacerbation during the entire 52 weeks of treatment
기간: Over the 52 weeks of treatment
Over the 52 weeks of treatment
Change from baseline in the 7-item Asthma Control Questionnaire (ACQ-7) at Week 12, Week 26 and Week 52 during study visits (using centralized spirometry)
기간: Baseline (pre-dose on Week 0) and Week 12, Week 26, Week 52

The 7-item Asthma Control Questionnaire (ACQ-7) score ranges from 0 to 6, with higher scores indicating worse asthma control.
Baseline (pre-dose on Week 0) and Week 12, Week 26, Week 52
Change from baseline in Asthma Quality of Life Questionnaire (AQLQ) at Week 12, Week 26 and Week 52 during study visits
기간: Baseline (pre-dose on Week 0) and Week 12, Week 26, Week 52

The Asthma Quality of Life Questionnaire (AQLQ) score ranges from 1 to 7, with higher scores indicating better asthma-related quality of life.
Baseline (pre-dose on Week 0) and Week 12, Week 26, Week 52
Change from baseline in pre-dose FEV1 at all clinical visits
기간: Baseline (pre-dose on Week 0) and applicable clinical visits
Baseline (pre-dose on Week 0) and applicable clinical visits
Change from baseline in 2h post-dose FEV1 at all clinical visits
기간: Baseline (pre-dose on Week 0) and all applicable clinical visits
Baseline (pre-dose on Week 0) and all applicable clinical visits
Proportion of subjects classified as responders in terms of pre-dose FEV1 at Week 26 and Week 52 (i.e., subjects with change from baseline in pre-dose FEV1 ≥100 mL)
기간: Baseline (pre-dose on Week 0) and Week 26, Week 52
Baseline (pre-dose on Week 0) and Week 26, Week 52
Change from baseline in 48h post-dose morning FEV1 after the last intake of study treatment at Week 52
기간: Week 52
Week 52
Change from baseline in weekly 5-item Asthma Control Questionnaire (ACQ-5) over the 52 weeks of treatment (performed at home by the subject)
기간: Baseline (pre-dose on Week 0) and over the 52 weeks of treatment

The 5-item Asthma Control Questionnaire (ACQ-5) score ranges from 0 to 6, with higher scores indicating worse asthma control.
Baseline (pre-dose on Week 0) and over the 52 weeks of treatment
Change from baseline in home spirometry parameters (e.g. FEV1, Forced Vital Capacity) over the 52 weeks of treatment (performed at home by the subject)
기간: Baseline (pre-dose on Week 0) and Over the 52 weeks of treatment
Baseline (pre-dose on Week 0) and Over the 52 weeks of treatment

공동 작업자 및 조사자

여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.

스폰서

Chiesi Farmaceutici S.p.A.

수사관

  • 수석 연구원: Stefan Zielen, MD, Institut für Atemwegserkrankungen Medaimun GmbH

연구 기록 날짜

이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.

연구 주요 날짜

연구 시작 (추정된)

2026년 11월 16일

기본 완료 (추정된)

2030년 6월 26일

연구 완료 (추정된)

2030년 6월 26일

연구 등록 날짜

최초 제출

2026년 9월 18일

QC 기준을 충족하는 최초 제출

2026년 10월 2일

처음 게시됨 (실제)

2026년 10월 5일

연구 기록 업데이트

마지막 업데이트 게시됨 (실제)

2026년 10월 5일

QC 기준을 충족하는 마지막 업데이트 제출

2026년 10월 2일

마지막으로 확인됨

2026년 10월 1일

추가 정보

이 연구와 관련된 용어

추가 관련 MeSH 약관

기타 연구 ID 번호

  • CLI-05993AA5-06
  • 2024-514248-95-00 (씨티스)

개별 참가자 데이터(IPD) 계획

개별 참가자 데이터(IPD)를 공유할 계획입니까?

아니요

약물 및 장치 정보, 연구 문서

미국 FDA 규제 의약품 연구

아니

미국 FDA 규제 기기 제품 연구

아니

이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .

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