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S0931, Everolimus i behandling av pasienter med nyrekreft som har gjennomgått kirurgi (S0931)

15. september 2025 oppdatert av: SWOG Cancer Research Network

EVEREST: EVERolimus for nyrekreft som følge av kirurgisk terapi, en fase III-studie

RASIONAL: Everolimus kan stoppe veksten av tumorceller ved å blokkere noen av enzymene som trengs for cellevekst eller ved å blokkere blodstrømmen til svulsten.

FORMÅL: Denne fase III-studien studerer everolimus for å se hvor godt det fungerer i behandling av pasienter med nyrekreft som har gjennomgått operasjon.

Studieoversikt

Status

Fullført

Forhold

Nyrekreft

Intervensjon / Behandling

Detaljert beskrivelse

MÅL:

Hoved

for å sammenligne residivfri overlevelse hos nyrekarsinompasienter tilfeldig fordelt til 54 uker med everolimus versus 54 uker med placebo etter nefrektomi eller partiell nefrektomi.

Sekundær

For å sammenligne den totale overlevelsen til pasienter behandlet med everolimus vs placebo.
For å sammenligne kvalitativ og kvantitativ toksisitet mellom de to studiearmene.
Å samle vev og biologiske prøver for fremtidig studie av molekylære biomarkører som er relevante for AKT/mTOR og andre veier som er involvert i patogenesen av nyrekarsinom og for å undersøke deres potensielle prediktive og prognostiske verdi.
Å banke blodprøver for den fremtidige studien av forholdet mellom steady-state bunnnivåer av everolimus og relevante bivirkninger (lymfopeni, infeksjon, hyperglykemi, hyperkolesterolemi, hypertriglyseridemi) hos pasienter behandlet i denne studien med everolimus.

OVERSIKT: Dette er en multisenterstudie.

Pasientene er stratifisert i henhold til patologisk stadium (middels høy risiko vs svært høy risiko), histologisk subtype (klare celler vs ikke-klare celler) og ytelsesstatus (0 vs 1). Pasientene er randomisert til 1 av 2 behandlingsarmer.

Arm I: Pasienter får oral everolimus én gang daglig på dag 1-42. Behandlingen gjentas hver 6. uke i 9 kurer i fravær av sykdomsprogresjon eller uakseptabel toksisitet.
Arm II: Pasienter får oral placebo én gang daglig på dag 1-42. Behandlingen gjentas hver 6. uke i 9 kurer i fravær av sykdomsprogresjon eller uakseptabel toksisitet.

Arkiverte tumorvevs-, plasma- og fullblodsprøver kan samles inn med jevne mellomrom for biomarkøranalyse og andre translasjonsstudier.

Etter avsluttet studiebehandling følges pasientene opp hver 6. måned i 2 år og deretter årlig i 8 år.

Studietype

Intervensjonell

Registrering (Faktiske)

1545

Fase

Fase 3

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

Forente stater
- Alabama
  - Birmingham, Alabama, Forente stater, 35233
    - University of Alabama at Birmingham
  - Mobile, Alabama, Forente stater, 36688
    - University of South Alabama Mitchell Cancer Institute
  - Mobile, Alabama, Forente stater, 36608
    - Providence Hospital
  - Mobile, Alabama, Forente stater, 36604
    - Gulf Coast MBCCOP
- Alaska
  - Fairbanks, Alaska, Forente stater, 99701
    - Fairbanks Memorial Hospital
- Arizona
  - Tucson, Arizona, Forente stater, 85704
    - Arizona Cancer Center at UMC Orange Grove
  - Tucson, Arizona, Forente stater, 85719
    - Arizona Cancer Center at University Medical Center North
  - Tucson, Arizona, Forente stater, 85724
    - University of Arizona Health Sciences Center
- Arkansas
  - Jonesboro, Arkansas, Forente stater, 72401
    - Fowler Family Center for Cancer Care
  - Little Rock, Arkansas, Forente stater, 72205
    - University of Arkansas for Medical Sciences
  - Little Rock, Arkansas, Forente stater, 72205
    - Veteran's Administration Medical Center
- California
  - Anaheim, California, Forente stater, 92807
    - Kaiser Anaheim Medical Center
  - Auburn, California, Forente stater, 95602
    - Sutter Auburn Faith Hospital
  - Baldwin Park, California, Forente stater, 91706
    - Kaiser Permanente Medical Group - Baldwin Park
  - Bellflower, California, Forente stater, 90706
    - Kaiser Foundation Hospital
  - Berkeley, California, Forente stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burbank, California, Forente stater, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Burlingame, California, Forente stater, 94010
    - Mills - Peninsula Hospitals
  - Castro Valley, California, Forente stater, 94546
    - East Bay Radiation Oncology Center
  - Castro Valley, California, Forente stater, 94546
    - Valley Medical Oncology Consultants-Castro Valley
  - Duarte, California, Forente stater, 91010
    - City of Hope Comprehensive Cancer Center
  - Dublin, California, Forente stater, 94568
    - Epic Care-Dublin
  - Fairfield, California, Forente stater, 94533
    - Northbay Cancer Center
  - Fontana, California, Forente stater, 92335
    - Kaiser Permanente Hospital
  - Fremont, California, Forente stater, 94538
    - Valley Medical Oncology Consultants-Fremont
  - Fremont, California, Forente stater, 94538
    - Washington Hospital
  - Fullerton, California, Forente stater, 92835
    - Saint Jude Medical Center
  - Glendale, California, Forente stater, 91204
    - Glendale Memorial Hospital and Health Center
  - Greenbrae, California, Forente stater, 94904
    - Marin Cancer Care Inc
  - Greenbrae, California, Forente stater, 94904
    - Marin General Hospital
  - Harbor City, California, Forente stater, 90710
    - Kaiser Permanente - Harbor City
  - Irvine, California, Forente stater, 92618
    - Southern California Permanente Medical Group
  - La Jolla, California, Forente stater, 92093
    - UC San Diego Moores Cancer Center
  - Long Beach, California, Forente stater, 90806
    - Long Beach Memorial Medical Center-Todd Cancer Institute
  - Los Angeles, California, Forente stater, 90033
    - USC / Norris Comprehensive Cancer Center
  - Los Angeles, California, Forente stater, 90048
    - Cedars-Sinai Medical Center
  - Los Angeles, California, Forente stater, 90033
    - Los Angeles County-USC Medical Center
  - Los Angeles, California, Forente stater, 90027
    - Kaiser Permanente Los Angeles Medical Center
  - Los Angeles, California, Forente stater, 90027
    - Kaiser Permanente
  - Los Angeles, California, Forente stater, 90034
    - Kaiser Permanente-West Los Angeles
  - Martinez, California, Forente stater, 94553-3156
    - Contra Costa Regional Medical Center
  - Marysville, California, Forente stater, 95901
    - Fremont - Rideout Cancer Center
  - Merced, California, Forente stater, 95340
    - Mercy UC Davis Cancer Center
  - Modesto, California, Forente stater, 95355
    - Memorial Medical Center
  - Mountain View, California, Forente stater, 94040
    - El Camino Hospital
  - Mountain View, California, Forente stater, 94040
    - Palo Alto Medical Foundation-Camino Division
  - Mountain View, California, Forente stater, 94040
    - Palo Alto Medical Foundation-Gynecologic Oncology
  - Novato, California, Forente stater, 94945
    - Sutter Cancer Research Consortium
  - Oakland, California, Forente stater, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Forente stater, 94602
    - Highland General Hospital
  - Oakland, California, Forente stater, 94609
    - Bay Area Breast Surgeons Inc
  - Oakland, California, Forente stater, 94609
    - Larry G Strieff MD Medical Corporation
  - Oakland, California, Forente stater, 94609
    - Tom K Lee Inc
  - Oakland, California, Forente stater, 94609
    - Bay Area Tumor Institute
  - Oakland, California, Forente stater, 94612
    - Epic Care-Oakland
  - Palo Alto, California, Forente stater, 94301
    - Palo Alto Medical Foundation Health Care
  - Panorama City, California, Forente stater, 91402
    - Kaiser Permanente - Panorama City
  - Pleasanton, California, Forente stater, 94588
    - Valley Medical Oncology Consultants
  - Rancho Mirage, California, Forente stater, 92270
    - Eisenhower Medical Center
  - Riverside, California, Forente stater, 92505
    - Kaiser Permanente Medical Center
  - Roseville, California, Forente stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forente stater, 95817
    - University of California Davis Comprehensive Cancer Center
  - Sacramento, California, Forente stater, 95816
    - Sutter General Hospital
  - San Diego, California, Forente stater, 92108
    - Kaiser Permanente-Mission
  - San Diego, California, Forente stater, 92120
    - Kaiser Permanente at San Diego
  - San Diego, California, Forente stater, 92120
    - Kaiser Permanente
  - San Francisco, California, Forente stater, 94115
    - UCSF Medical Center-Mount Zion
  - San Francisco, California, Forente stater, 94118
    - California Pacific Medical Center-Pacific Campus
  - San Marcos, California, Forente stater, 92069
    - Kaiser Permanente Health Care
  - San Pablo, California, Forente stater, 94806
    - Doctors Medical Center- JC Robinson Regional Cancer Center
  - Santa Cruz, California, Forente stater, 95065
    - Palo Alto Medical Foundation-Santa Cruz
  - Santa Rosa, California, Forente stater, 95403
    - Sutter Pacific Medical Foundation
  - Sunnyvale, California, Forente stater, 94806
    - Palo Atlo Medical Foundation-Sunnyvale
  - Truckee, California, Forente stater, 96161
    - Tahoe Forest Cancer Center
  - Vallejo, California, Forente stater, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Whittier, California, Forente stater, 90602
    - Presbyterian Intercommunity Hospital
  - Woodland Hills, California, Forente stater, 91367
    - Kaiser Permanente
- Colorado
  - Aurora, Colorado, Forente stater, 80045
    - University of Colorado Cancer Center - Anschutz Cancer Pavilion
  - Aurora, Colorado, Forente stater, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Forente stater, 80012
    - The Medical Center of Aurora
  - Boulder, Colorado, Forente stater, 80301
    - Boulder Community Hospital
  - Boulder, Colorado, Forente stater, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Colorado Springs, Colorado, Forente stater, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Forente stater, 80907
    - Rocky Mountain Cancer Centers-Penrose
  - Colorado Springs, Colorado, Forente stater, 80909
    - Memorial Hospital Colorado Springs
  - Denver, Colorado, Forente stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forente stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forente stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forente stater, 80218
    - Exempla Saint Joseph Hospital
  - Denver, Colorado, Forente stater, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Forente stater, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Forente stater, 80907
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Forente stater, 80224-2522
    - Colorado Cancer Research Program CCOP
  - Denver, Colorado, Forente stater, 80220
    - Denver Veterans Administration Medical Center
  - Durango, Colorado, Forente stater, 81301
    - Mercy Medical Center
  - Durango, Colorado, Forente stater, 81301
    - Southwest Oncology PC
  - Edwards, Colorado, Forente stater, 81632
    - The Shaw Regional Cancer Center
  - Englewood, Colorado, Forente stater, 80113
    - Swedish Medical Center
  - Englewood, Colorado, Forente stater, 80113
    - Comprehensive Cancer Care and Research Institute of Colorado LLC
  - Fort Collins, Colorado, Forente stater, 80524
    - Poudre Valley Hospital
  - Glenwood Springs, Colorado, Forente stater, 81601
    - Valley View Hospital Cancer Center
  - Golden, Colorado, Forente stater, 80401
    - Mountain Blue Cancer Care Center
  - Grand Junction, Colorado, Forente stater, 81502
    - Saint Mary's Hospital and Regional Medical Center
  - Greeley, Colorado, Forente stater, 80631
    - North Colorado Medical Center
  - Greenwood Village, Colorado, Forente stater, 80111
    - Rocky Mountain Cancer Centers-Greenwood Village
  - Lakewood, Colorado, Forente stater, 80228
    - Saint Anthony Hospital
  - Lakewood, Colorado, Forente stater, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Littleton, Colorado, Forente stater, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton, Colorado, Forente stater, 80122
    - Littleton Adventist Hospital
  - Lone Tree, Colorado, Forente stater, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Forente stater, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Longmont, Colorado, Forente stater, 80501
    - Longmont United Hospital
  - Longmont, Colorado, Forente stater, 80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland, Colorado, Forente stater, 80539
    - McKee Medical Center
  - Parker, Colorado, Forente stater, 80138
    - Parker Adventist Hospital
  - Parker, Colorado, Forente stater, 80138
    - Rocky Mountain Cancer Centers-Parker
  - Pueblo, Colorado, Forente stater, 81004
    - Saint Mary Corwin Medical Center
  - Pueblo, Colorado, Forente stater, 81008
    - Rocky Mountain Cancer Centers - Pueblo
  - Thornton, Colorado, Forente stater, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Thornton, Colorado, Forente stater, 80229
    - North Suburban Medical Center
  - Wheat Ridge, Colorado, Forente stater, 80033
    - Exempla Lutheran Medical Center
- Connecticut
  - Danbury, Connecticut, Forente stater, 06810
    - Danbury Hospital
  - Farmington, Connecticut, Forente stater, 06030
    - University of Connecticut
  - Hartford, Connecticut, Forente stater, 06105
    - Saint Francis Hospital and Medical Center
  - Manchester, Connecticut, Forente stater, 06040
    - Manchester Memorial Hospital
  - Middletown, Connecticut, Forente stater, 06457
    - Middlesex Hospital
  - New Britain, Connecticut, Forente stater, 06050
    - The Hospital of Central Connecticut
  - New Haven, Connecticut, Forente stater, 06520
    - Yale University
  - Norwich, Connecticut, Forente stater, 06360
    - Eastern Connecticut Hematology and Oncology Associates
- Delaware
  - Lewes, Delaware, Forente stater, 19958
    - Beebe Medical Center
  - Newark, Delaware, Forente stater, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Forente stater, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, Forente stater, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Forente stater, 19718
    - Christiana Care Health System-Christiana Hospital
  - Newark, Delaware, Forente stater, 19713
    - Christiana Gynecologic Oncology LLC
  - Newark, Delaware, Forente stater, 19713
    - Regional Hematology and Oncology PA
  - Rehoboth Beach, Delaware, Forente stater, 19971
    - Beebe Health Campus
  - Seaford, Delaware, Forente stater, 19973
    - Nanticoke Memorial Hospital
  - Wilmington, Delaware, Forente stater, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington D.C., District of Columbia, Forente stater, 20037
    - George Washington University Medical Center
  - Washington D.C., District of Columbia, Forente stater, 20010
    - Washington Hospital Center
  - Washington D.C., District of Columbia, Forente stater, 20057
    - Lombardi Comprehensive Cancer Center at Georgetown University
- Florida
  - Altamonte Springs, Florida, Forente stater, 32701
    - Florida Hospital Cancer Institute Altamonte
  - Fort Lauderdale, Florida, Forente stater, 33308
    - Holy Cross Hospital
  - Jupiter, Florida, Forente stater, 33458
    - Jupiter Medical Center
  - Kissimmee, Florida, Forente stater, 34744
    - Florida Hospital Kissimmee
  - Lakeland, Florida, Forente stater, 33805
    - Lakeland Regional Cancer Center
  - Lakeland, Florida, Forente stater, 33805
    - The Watson Clinic
  - Miami Beach, Florida, Forente stater, 33140
    - Mount Sinai Medical Center
  - Orlando, Florida, Forente stater, 32803
    - Florida Hospital Orlando
  - Orlando, Florida, Forente stater, 32806
    - UF Cancer Center at Orlando Health
  - Orlando, Florida, Forente stater, 32803
    - Florida Urology Associates-Orlando
  - Orlando, Florida, Forente stater, 32822
    - Florida Hospital East Orlando
  - Pensacola, Florida, Forente stater, 32504
    - Sacred Heart Hospital
  - Pensacola, Florida, Forente stater, 32514
    - Sacred Heart Medical Oncology Group - Davis Highway
  - Weston, Florida, Forente stater, 33331
    - Cleveland Clinic Florida - Weston
  - Winter Park, Florida, Forente stater, 32792
    - Florida Hospital Cancer Institute Winter Park
- Georgia
  - Albany, Georgia, Forente stater, 31701
    - Phoebe Putney Memorial Hospital
  - Athens, Georgia, Forente stater, 30607
    - University Cancer and Blood Center LLC
  - Atlanta, Georgia, Forente stater, 30309
    - Piedmont Hospital
  - Atlanta, Georgia, Forente stater, 30322
    - Emory University/Winship Cancer Institute
  - Atlanta, Georgia, Forente stater, 30342
    - Northside Hospital
  - Atlanta, Georgia, Forente stater, 30342
    - Saint Joseph's Hospital of Atlanta
  - Atlanta, Georgia, Forente stater, 30342
    - Atlanta Regional CCOP
  - Augusta, Georgia, Forente stater, 30912
    - Georgia Regents University Medical Center
  - Austell, Georgia, Forente stater, 30106
    - Well Star Cobb Hospital
  - Columbus, Georgia, Forente stater, 31904
    - John B Amos Cancer Center
  - Decatur, Georgia, Forente stater, 30033
    - Dekalb Medical Center
  - Fayetteville, Georgia, Forente stater, 30214
    - Piedmont Fayette Hospital
  - Lawrenceville, Georgia, Forente stater, 30045
    - Gwinnett Medical Center
  - Macon, Georgia, Forente stater, 31208
    - Medical Center of Central Georgia
  - Marietta, Georgia, Forente stater, 30060
    - Wellstar Kennestone Hospital
  - Riverdale, Georgia, Forente stater, 30274
    - Southern Regional Medical Center
  - Rome, Georgia, Forente stater, 30165
    - Harbin Clinic Medical Oncology and Clinical Research
  - Savannah, Georgia, Forente stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Valdosta, Georgia, Forente stater, 31603
    - South Georgia Medical Center
- Hawaii
  - Honolulu, Hawaii, Forente stater, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Forente stater, 96817
    - The Cancer Center of Hawaii-Liliha
  - Honolulu, Hawaii, Forente stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forente stater, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Forente stater, 96817
    - Kuakini Medical Center
  - Honolulu, Hawaii, Forente stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forente stater, 96859
    - Tripler Army Medical Center
  - Honolulu, Hawaii, Forente stater, 96813
    - Oncare Hawaii Inc-POB II
  - Honolulu, Hawaii, Forente stater, 96817-3169
    - OnCare Hawaii-Liliha
  - Honolulu, Hawaii, Forente stater, 96817
    - Oncare Hawaii Inc-Kuakini
  - Kailua, Hawaii, Forente stater, 96734
    - Castle Medical Center
  - Lihue, Hawaii, Forente stater, 96766
    - Wilcox Memorial Hospital and Kauai Medical Clinic
  - ‘Aiea, Hawaii, Forente stater, 96701
    - Pali Momi Medical Center
  - ‘Aiea, Hawaii, Forente stater, 96701
    - Oncare Hawaii Inc-Pali Momi
  - ‘Ewa Beach, Hawaii, Forente stater, 96706
    - Leeward Radiation Oncology Center
- Idaho
  - Boise, Idaho, Forente stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Forente stater, 83712
    - Saint Luke's Mountain States Tumor Institute
  - Coeur d'Alene, Idaho, Forente stater, 83814
    - Kootenai Medical Center
  - Fruitland, Idaho, Forente stater, 83619
    - Saint Luke's Mountain States Tumor Institute - Fruitland
  - Lewiston, Idaho, Forente stater, 83501
    - Saint Joseph Regional Medical Center
  - Meridian, Idaho, Forente stater, 83642
    - Idaho Urologic Institute-Meridian
  - Meridian, Idaho, Forente stater, 83642
    - Saint Luke's Mountain States Tumor Institute - Meridian
  - Nampa, Idaho, Forente stater, 83686
    - Saint Luke's Mountain States Tumor Institute - Nampa
  - Post Falls, Idaho, Forente stater, 83854
    - Kootenai Cancer Center
  - Sandpoint, Idaho, Forente stater, 83864
    - Kootenai Cancer
  - Twin Falls, Idaho, Forente stater, 83301
    - Saint Luke's Mountain States Tumor Institute-Twin Falls
- Illinois
  - Alton, Illinois, Forente stater, 62002
    - Saint Anthony's Health
  - Aurora, Illinois, Forente stater, 60504
    - Rush - Copley Medical Center
  - Berwyn, Illinois, Forente stater, 60402
    - Mac Neal Hospital
  - Bloomington, Illinois, Forente stater, 61701
    - Saint Joseph Medical Center
  - Bloomington, Illinois, Forente stater, 61701
    - Illinois CancerCare-Bloomington
  - Canton, Illinois, Forente stater, 61520
    - Illinois CancerCare-Canton
  - Canton, Illinois, Forente stater, 61520
    - Graham Hospital Association
  - Carbondale, Illinois, Forente stater, 62902
    - Memorial Hospital of Carbondale
  - Carthage, Illinois, Forente stater, 62321
    - Illinois CancerCare-Carthage
  - Carthage, Illinois, Forente stater, 62321
    - Memorial Hospital
  - Centralia, Illinois, Forente stater, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Forente stater, 60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago, Illinois, Forente stater, 60612
    - University of Illinois
  - Chicago, Illinois, Forente stater, 60640
    - Weiss Memorial Hospital
  - Chicago, Illinois, Forente stater, 60631
    - Resurrection Healthcare
  - Danville, Illinois, Forente stater, 61832
    - Carle on Vermilion
  - Decatur, Illinois, Forente stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forente stater, 62526
    - Cancer Care Center of Decatur
  - Decatur, Illinois, Forente stater, 62526
    - Central Illinois CCOP
  - Effingham, Illinois, Forente stater, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Forente stater, 62401
    - Carle Physician Group-Effingham
  - Eureka, Illinois, Forente stater, 61530
    - Illinois CancerCare-Eureka
  - Eureka, Illinois, Forente stater, 61530
    - Eureka Hospital
  - Evanston, Illinois, Forente stater, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Galesburg, Illinois, Forente stater, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Forente stater, 61401
    - Illinois CancerCare Galesburg
  - Galesburg, Illinois, Forente stater, 61401
    - Illinois CancerCare-Galesburg Cottage Plaza Office
  - Geneva, Illinois, Forente stater, 60134
    - Cadence Cancer Center at Delnor
  - Glenview, Illinois, Forente stater, 60026
    - NorthShore University HealthSystem-Glenbrook Hospital
  - Havana, Illinois, Forente stater, 62644
    - Mason District Hospital
  - Havana, Illinois, Forente stater, 62644
    - Illinois CancerCare-Havana
  - Highland Park, Illinois, Forente stater, 60035
    - NorthShore University HealthSystem-Highland Park Hospital
  - Hines, Illinois, Forente stater, 60141
    - Hines Veterans Administration Hospital
  - Joliet, Illinois, Forente stater, 60435
    - Joliet Oncology-Hematology Associates Limited
  - Kankakee, Illinois, Forente stater, 60901
    - Presence Saint Mary's Hospital
  - Kewanee, Illinois, Forente stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - La Grange, Illinois, Forente stater, 60525
    - Adventist La Grange Memorial Hospital
  - Macomb, Illinois, Forente stater, 61455
    - Illinois CancerCare-Macomb
  - Macomb, Illinois, Forente stater, 61455
    - Mcdonough District Hospital
  - Mattoon, Illinois, Forente stater, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Maywood, Illinois, Forente stater, 60153
    - Loyola University Medical Center
  - Monmouth, Illinois, Forente stater, 61462
    - Illinois CancerCare-Monmouth
  - Monmouth, Illinois, Forente stater, 61462
    - Holy Family Medical Center
  - Mount Vernon, Illinois, Forente stater, 62864
    - Good Samaritan Regional Health Center
  - Naperville, Illinois, Forente stater, 60540
    - Edward Hospital/Cancer Center
  - New Lenox, Illinois, Forente stater, 60451
    - UC Comprehensive Cancer Center at Silver Cross
  - Normal, Illinois, Forente stater, 61761
    - Community Cancer Center Foundation
  - Normal, Illinois, Forente stater, 61761
    - Bromenn Regional Medical Center
  - Normal, Illinois, Forente stater, 61761
    - Illinois CancerCare-Community Cancer Center
  - Normal, Illinois, Forente stater, 61761
    - Mid-Illinois Hematology Oncology Associates
  - Oak Lawn, Illinois, Forente stater, 60453-2699
    - Advocate Christ Medical Center
  - Ottawa, Illinois, Forente stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Ottawa, Illinois, Forente stater, 61350
    - Radiation Oncology of Northern Illinois
  - Ottawa, Illinois, Forente stater, 61350
    - Ottawa Regional Hospital and Healthcare Center
  - Pekin, Illinois, Forente stater, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Forente stater, 61554
    - Pekin Cancer Treatment Center
  - Peoria, Illinois, Forente stater, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Forente stater, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Forente stater, 61614
    - Proctor Hospital
  - Peoria, Illinois, Forente stater, 61603
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forente stater, 61615-7827
    - OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC
  - Peoria, Illinois, Forente stater, 61615
    - Illinois Oncology Research Association CCOP
  - Peru, Illinois, Forente stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forente stater, 61354
    - Valley Radiation Oncology
  - Peru, Illinois, Forente stater, 61354
    - Illinois Valley Hospital
  - Princeton, Illinois, Forente stater, 61356
    - Illinois CancerCare-Princeton
  - Princeton, Illinois, Forente stater, 61356
    - Perry Memorial Hospital
  - River Forest, Illinois, Forente stater, 60305
    - West Suburban Medical Center
  - Rockford, Illinois, Forente stater, 61107
    - SwedishAmerican Regional Cancer Center/ACT
  - Spring Valley, Illinois, Forente stater, 61362
    - Illinois CancerCare-Spring Valley
  - Springfield, Illinois, Forente stater, 62702
    - Central Illinois Hematology Oncology Center
  - Springfield, Illinois, Forente stater, 62781-0001
    - Memorial Medical Center
  - Urbana, Illinois, Forente stater, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Forente stater, 61801
    - The Carle Foundation Hospital
  - Warrenville, Illinois, Forente stater, 60555
    - Cadence Cancer Center in Warrenville
  - Yorkville, Illinois, Forente stater, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Elkhart, Indiana, Forente stater, 46515
    - Elkhart General Hospital
  - Elkhart, Indiana, Forente stater, 46514
    - Michiana Hematology Oncology PC-Elkhart
  - Elkhart, Indiana, Forente stater, 46514-2098
    - Elkhart Clinic
  - Indianapolis, Indiana, Forente stater, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Forente stater, 46202
    - Richard L. Roudebush Veterans Affairs Medical Center
  - Indianapolis, Indiana, Forente stater, 46237
    - Franciscan Saint Francis Health-Indianapolis
  - Kokomo, Indiana, Forente stater, 46904
    - Community Howard Regional Health
  - La Porte, Indiana, Forente stater, 46350
    - IU Health La Porte Hospital
  - Merrillville, Indiana, Forente stater, 46410
    - Premier Oncology Hematology Associates
  - Michigan City, Indiana, Forente stater, 46360
    - Franciscan Saint Anthony Health-Michigan City
  - Michigan City, Indiana, Forente stater, 46360
    - Woodland Cancer Care Center
  - Mishawaka, Indiana, Forente stater, 46544
    - Memorial Regional Cancer Center Day Road
  - Mishawaka, Indiana, Forente stater, 46545
    - Michiana Hematology Oncology PC-Mishawaka
  - Mishawaka, Indiana, Forente stater, 46545
    - Cancer Care Partners LLC
  - Mishawaka, Indiana, Forente stater, 46545
    - Saint Joseph Regional Medical Center-Mishawaka
  - Munster, Indiana, Forente stater, 46321
    - The Community Hospital
  - Plymouth, Indiana, Forente stater, 46563
    - Michiana Hematology Oncology PC-Plymouth
  - Richmond, Indiana, Forente stater, 47374
    - Reid Hospital and Health Care Services
  - South Bend, Indiana, Forente stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forente stater, 46601
    - Michiana Hematology Oncology PC-South Bend
  - South Bend, Indiana, Forente stater, 46628
    - Northern Indiana Cancer Research Consortium
  - South Bend, Indiana, Forente stater, 46617
    - South Bend Clinic
  - Westville, Indiana, Forente stater, 46391
    - Michiana Hematology Oncology-PC Westville
- Iowa
  - Ames, Iowa, Forente stater, 50010
    - Mary Greeley Medical Center
  - Ames, Iowa, Forente stater, 50010
    - McFarland Clinic PC-William R Bliss Cancer Center
  - Bettendorf, Iowa, Forente stater, 52722
    - Hematology Oncology Associates-Quad Cities
  - Boone, Iowa, Forente stater, 50036
    - McFarland Clinic PC-Boone
  - Cedar Rapids, Iowa, Forente stater, 52403
    - Oncology Associates at Mercy Medical Center
  - Cedar Rapids, Iowa, Forente stater, 52403
    - Cedar Rapids Oncology Association
  - Clive, Iowa, Forente stater, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, Forente stater, 50325
    - Medical Oncology and Hematology Associates-West Des Moines
  - Council Bluffs, Iowa, Forente stater, 51503
    - Alegent Health Mercy Hospital
  - Davenport, Iowa, Forente stater, 52803
    - Genesis Medical Center - East Campus
  - Des Moines, Iowa, Forente stater, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Forente stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forente stater, 50309
    - Medical Oncology and Hematology Associates-Des Moines
  - Des Moines, Iowa, Forente stater, 50316
    - Iowa Lutheran Hospital
  - Des Moines, Iowa, Forente stater, 50314
    - Medical Oncology and Hematology Associates-Laurel
  - Fort Dodge, Iowa, Forente stater, 50501
    - McFarland Clinic PC-Trinity Cancer Center
  - Iowa City, Iowa, Forente stater, 52242
    - University of Iowa Hospitals and Clinics
  - Jefferson, Iowa, Forente stater, 50129
    - McFarland Clinic PC-Jefferson
  - Marshalltown, Iowa, Forente stater, 50158
    - McFarland Clinic PC-Marshalltown
  - Mason City, Iowa, Forente stater, 50401
    - Mercy Medical Center - North Iowa
  - Sioux City, Iowa, Forente stater, 51104
    - Saint Luke's Regional Medical Center
  - Sioux City, Iowa, Forente stater, 51101
    - Siouxland Hematology Oncology Associates
  - Sioux City, Iowa, Forente stater, 51104
    - Mercy Medical Center-Sioux City
  - West Des Moines, Iowa, Forente stater, 50266-7700
    - Methodist West Hospital
  - West Des Moines, Iowa, Forente stater, 50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Chanute, Kansas, Forente stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forente stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forente stater, 67042
    - Cancer Center of Kansas - El Dorado
  - Emporia, Kansas, Forente stater, 66801
    - Newman Regional Health
  - Fort Scott, Kansas, Forente stater, 66701
    - Cancer Center of Kansas - Fort Scott
  - Garden City, Kansas, Forente stater, 67846
    - Saint Catherine Hospital
  - Great Bend, Kansas, Forente stater, 67530
    - Saint Rose Ambulatory and Surgery Center
  - Hays, Kansas, Forente stater, 67601
    - Hays Medical Center
  - Hutchinson, Kansas, Forente stater, 65702
    - Promise Regional Medical Center-Hutchinson
  - Independence, Kansas, Forente stater, 67301
    - Cancer Center of Kansas-Independence
  - Kansas City, Kansas, Forente stater, 66160
    - University of Kansas Medical Center
  - Kansas City, Kansas, Forente stater, 66112
    - Kansas City Cancer Center-West
  - Kansas City, Kansas, Forente stater, 66112
    - Providence Medical Center
  - Kingman, Kansas, Forente stater, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Forente stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forente stater, 67901
    - Cancer Center of Kansas-Liberal
  - Manhattan, Kansas, Forente stater, 66502
    - Cancer Center of Kansas-Manhattan
  - McPherson, Kansas, Forente stater, 67460
    - Cancer Center of Kansas - McPherson
  - Newton, Kansas, Forente stater, 67114
    - Cancer Center of Kansas - Newton
  - Olathe, Kansas, Forente stater, 66061
    - Olathe Medical Center
  - Overland Park, Kansas, Forente stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forente stater, 66213
    - Saint Luke's South Hospital
  - Overland Park, Kansas, Forente stater, 66210
    - Kansas City Cancer Centers-Southwest
  - Parsons, Kansas, Forente stater, 67357
    - Cancer Center of Kansas - Parsons
  - Pittsburg, Kansas, Forente stater, 66762
    - Via Christi Hospital-Pittsburg
  - Prairie Village, Kansas, Forente stater, 66208
    - Kansas City CCOP
  - Pratt, Kansas, Forente stater, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Forente stater, 67401
    - Salina Regional Health Center
  - Salina, Kansas, Forente stater, 67401
    - Cancer Center of Kansas - Salina
  - Shawnee Mission, Kansas, Forente stater, 66204
    - Kansas City Cancer Center-Shawnee Mission
  - Topeka, Kansas, Forente stater, 66606
    - Saint Francis Hospital and Medical Center - Topeka
  - Topeka, Kansas, Forente stater, 66604
    - Stormont-Vail Regional Health Center
  - Wellington, Kansas, Forente stater, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Forente stater, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Forente stater, 67208
    - Associates In Womens Health
  - Wichita, Kansas, Forente stater, 67214
    - Cancer Center of Kansas - Main Office
  - Wichita, Kansas, Forente stater, 67214
    - Via Christi Regional Medical Center
  - Wichita, Kansas, Forente stater, 67214
    - Wesley Medical Center
  - Wichita, Kansas, Forente stater, 67214
    - Wichita CCOP
  - Winfield, Kansas, Forente stater, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Bardstown, Kentucky, Forente stater, 40004
    - Flaget Memorial Hospital
  - Corbin, Kentucky, Forente stater, 40701
    - Commonwealth Cancer Center-Corbin
  - Crestview Hills, Kentucky, Forente stater, 41017
    - Oncology Hematology Care Inc-Crestview
  - Lexington, Kentucky, Forente stater, 40504
    - Saint Joseph Radiation Oncology Resource Center
  - Lexington, Kentucky, Forente stater, 40509
    - Saint Joseph Hospital East
  - Louisville, Kentucky, Forente stater, 40202
    - Jewish Hospital
  - Louisville, Kentucky, Forente stater, 40215
    - Saints Mary and Elizabeth Hospital
  - Louisville, Kentucky, Forente stater, 40245
    - Jewish Hospital Medical Center Northeast
  - Owensboro, Kentucky, Forente stater, 42303
    - Owensboro Health Mitchell Memorial Cancer Center
  - Shepherdsville, Kentucky, Forente stater, 40165
    - Jewish Hospital Medical Center South
- Louisiana
  - Baton Rouge, Louisiana, Forente stater, 70809
    - Mary Bird Perkins Cancer Center
  - Metairie, Louisiana, Forente stater, 70006
    - East Jefferson General Hospital
  - Metairie, Louisiana, Forente stater, 70006
    - Robert Veith MD LLC
  - Monroe, Louisiana, Forente stater, 71202
    - Louisiana State University Sciences Center- Monroe
  - New Orleans, Louisiana, Forente stater, 70121
    - Ochsner Medical Center Jefferson
  - New Orleans, Louisiana, Forente stater, 70112
    - Louisiana State University Health Science Center
  - New Orleans, Louisiana, Forente stater, 70112
    - Interim LSU Public Hospital
  - Shreveport, Louisiana, Forente stater, 71103
    - Louisiana State University Health Sciences Center Shreveport
  - Shreveport, Louisiana, Forente stater, 71105
    - Highland Clinic
- Maine
  - Augusta, Maine, Forente stater, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Forente stater, 04401
    - Eastern Maine Medical Center
  - Brewer, Maine, Forente stater, 04412
    - Lafayette Family Cancer Center-EMMC
  - Rockport, Maine, Forente stater, 04856
    - Penobscot Bay Medical Center
  - York Village, Maine, Forente stater, 03909
    - York Hospital
- Maryland
  - Baltimore, Maryland, Forente stater, 21204
    - Greater Baltimore Medical Center
  - Baltimore, Maryland, Forente stater, 21201
    - University of Maryland/Greenebaum Cancer Center
  - Baltimore, Maryland, Forente stater, 21201
    - Veterans Administration Medical Center-Baltimore
  - Bethesda, Maryland, Forente stater, 20889-5600
    - Walter Reed National Military Medical Center
  - Easton, Maryland, Forente stater, 21601
    - The Memorial Hospital at Easton
  - Elkton, Maryland, Forente stater, 21921
    - Union Hospital of Cecil County
  - Rockville, Maryland, Forente stater, 20850
    - Associates In Oncology Hematology PC-Rockville
  - Salisbury, Maryland, Forente stater, 21801
    - Peninsula Regional Medical Center
  - Silver Spring, Maryland, Forente stater, 20910
    - Holy Cross Hospital
- Massachusetts
  - Beverly, Massachusetts, Forente stater, 01915
    - Beverly Hospital
  - Boston, Massachusetts, Forente stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forente stater, 02115
    - Dana-Farber Cancer Institute
  - Boston, Massachusetts, Forente stater, 02115
    - Brigham and Women's Hospital
  - Boston, Massachusetts, Forente stater, 02118
    - Boston Medical Center
  - Brighton, Massachusetts, Forente stater, 02135-2997
    - Caritas Saint Elizabeth's Medical Center
  - Burlington, Massachusetts, Forente stater, 01805
    - Lahey Hospital and Medical Center
  - Gloucester, Massachusetts, Forente stater, 01930
    - Addison Gilbert Hospital
  - Lowell, Massachusetts, Forente stater, 01854
    - Lowell General Hospital
  - Methuen, Massachusetts, Forente stater, 01844
    - Holy Family Hospital
  - Springfield, Massachusetts, Forente stater, 01199
    - Baystate Medical Center
- Michigan
  - Adrian, Michigan, Forente stater, 49221
    - Bixby Medical Center
  - Adrian, Michigan, Forente stater, 49221
    - Hickman Cancer Center
  - Ann Arbor, Michigan, Forente stater, 48109
    - University of Michigan
  - Ann Arbor, Michigan, Forente stater, 48106-0995
    - Saint Joseph Mercy Hospital
  - Ann Arbor, Michigan, Forente stater, 48106
    - Michigan Cancer Research Consortium Community Clinical Oncology Program
  - Ann Arbor, Michigan, Forente stater, 48109
    - University of Michigan University Hospital
  - Battle Creek, Michigan, Forente stater, 49017
    - Bronson Battle Creek
  - Bay City, Michigan, Forente stater, 48708
    - McLaren-Bay Region
  - Big Rapids, Michigan, Forente stater, 49307
    - Spectrum Health Big Rapids Hospital
  - Clarkston, Michigan, Forente stater, 48346
    - Great Lakes Cancer Institute
  - Dearborn, Michigan, Forente stater, 48124
    - Oakwood Hospital and Medical Center
  - Detroit, Michigan, Forente stater, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Forente stater, 48236
    - Saint John Hospital and Medical Center
  - Detroit, Michigan, Forente stater, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Escanaba, Michigan, Forente stater, 49431
    - Green Bay Oncology - Escanaba
  - Farmington Hills, Michigan, Forente stater, 48334
    - Weisberg Cancer Treatment Center
  - Flint, Michigan, Forente stater, 48502
    - Hurley Medical Center
  - Flint, Michigan, Forente stater, 48532
    - Genesys Regional Medical Center-West Flint Campus
  - Flint, Michigan, Forente stater, 48532
    - Singh and Arora Hematology Oncology PC
  - Flint, Michigan, Forente stater, 48503
    - Genesys Hurley Cancer Institute
  - Grand Blanc, Michigan, Forente stater, 48439
    - Genesys Regional Medical Center
  - Grand Rapids, Michigan, Forente stater, 49503
    - Spectrum Health at Butterworth Campus
  - Grand Rapids, Michigan, Forente stater, 49503
    - Mercy Health Saint Mary's
  - Grand Rapids, Michigan, Forente stater, 49503
    - Grand Rapids Clinical Oncology Program
  - Iron Mountain, Michigan, Forente stater, 49801
    - Green Bay Oncology - Iron Mountain
  - Jackson, Michigan, Forente stater, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Forente stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forente stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forente stater, 49001
    - Borgess Medical Center
  - Lansing, Michigan, Forente stater, 48912
    - Sparrow Hospital
  - Lapeer, Michigan, Forente stater, 48446
    - Great Lakes Cancer Institute-Lapeer Campus
  - Livonia, Michigan, Forente stater, 48154
    - Saint Mary Mercy Hospital
  - Monroe, Michigan, Forente stater, 48162
    - Mercy Memorial Hospital
  - Monroe, Michigan, Forente stater, 48162
    - Community Cancer Center of Monroe
  - Muskegon, Michigan, Forente stater, 49444
    - Mercy Health Mercy Campus
  - Niles, Michigan, Forente stater, 49120
    - Lakeland Community Hospital
  - Petoskey, Michigan, Forente stater, 49770
    - Northern Michigan Regional Hospital
  - Pontiac, Michigan, Forente stater, 48341
    - Saint Joseph Mercy Oakland
  - Port Huron, Michigan, Forente stater, 48060
    - Saint Joseph Mercy Port Huron
  - Reed City, Michigan, Forente stater, 49677
    - Spectrum Health Reed City Hospital
  - Royal Oak, Michigan, Forente stater, 48073
    - William Beaumont Hospital-Royal Oak
  - Saginaw, Michigan, Forente stater, 48601
    - Saint Mary's of Michigan
  - Saint Joseph, Michigan, Forente stater, 49085
    - Marie Yeager Cancer Center
  - Saint Joseph, Michigan, Forente stater, 49085
    - Lakeland Hospital
  - Traverse City, Michigan, Forente stater, 49684
    - Munson Medical Center
  - Troy, Michigan, Forente stater, 48098
    - William Beaumont Hospital - Troy
  - Warren, Michigan, Forente stater, 48093
    - Saint John Macomb-Oakland Hospital
  - Wyoming, Michigan, Forente stater, 49519
    - Metro Health Hospital
- Minnesota
  - Alexandria, Minnesota, Forente stater, 56308
    - Medini, Eitan MD (UIA Investigator)
  - Bemidji, Minnesota, Forente stater, 56601
    - Sanford Clinic North-Bemidgi
  - Brainerd, Minnesota, Forente stater, 56401
    - Essentia Health Saint Joseph's Medical Center
  - Burnsville, Minnesota, Forente stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forente stater, 55433
    - Mercy Hospital
  - Duluth, Minnesota, Forente stater, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Forente stater, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Forente stater, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Forente stater, 55435
    - Fairview-Southdale Hospital
  - Fergus Falls, Minnesota, Forente stater, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fridley, Minnesota, Forente stater, 55432
    - Unity Hospital
  - Hutchinson, Minnesota, Forente stater, 55350
    - Hutchinson Area Health Care
  - Maplewood, Minnesota, Forente stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forente stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forente stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forente stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forente stater, 55454
    - Health Partners Inc
  - Minneapolis, Minnesota, Forente stater, 55417
    - Minneapolis Veterans Medical Center
  - New Ulm, Minnesota, Forente stater, 56073
    - New Ulm Medical Center
  - Robbinsdale, Minnesota, Forente stater, 55422
    - North Memorial Medical Health Center
  - Rochester, Minnesota, Forente stater, 55905
    - Mayo Clinic
  - Saint Cloud, Minnesota, Forente stater, 56303
    - Coborn Cancer Center at Saint Cloud Hospital
  - Saint Cloud, Minnesota, Forente stater, 56303
    - Saint Cloud Hospital
  - Saint Louis Park, Minnesota, Forente stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Louis Park, Minnesota, Forente stater, 55416
    - Metro-Minnesota CCOP
  - Saint Paul, Minnesota, Forente stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forente stater, 55102
    - United Hospital
  - Shakopee, Minnesota, Forente stater, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Forente stater, 55082
    - Lakeview Hospital
  - Waconia, Minnesota, Forente stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forente stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forente stater, 55125
    - Minnesota Oncology and Hematology PA-Woodbury
- Mississippi
  - Hattiesburg, Mississippi, Forente stater, 39404
    - Forest General Hospital
  - Jackson, Mississippi, Forente stater, 39216
    - University of Mississippi Medical Center
- Missouri
  - Bolivar, Missouri, Forente stater, 65613
    - Central Care Cancer Center-Carrie J Babb Cancer Center
  - Bonne Terre, Missouri, Forente stater, 63628
    - Parkland Health Center-Bonne Terre
  - Branson, Missouri, Forente stater, 65616
    - CoxHealth Cancer Center
  - Cape Girardeau, Missouri, Forente stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forente stater, 63703
    - Southeast Cancer Center
  - Chesterfield, Missouri, Forente stater, 63017
    - Saint Luke's Hospital
  - City of Saint Peters, Missouri, Forente stater, 63376
    - Siteman Cancer Center - Saint Peters
  - Independence, Missouri, Forente stater, 64057
    - Centerpoint Medical Center LLC
  - Jefferson City, Missouri, Forente stater, 65109
    - Capital Region Medical Center-Goldschmidt Cancer Center
  - Joplin, Missouri, Forente stater, 64804
    - Freeman Health System
  - Joplin, Missouri, Forente stater, 64804
    - Mercy Hospital-Joplin
  - Kansas City, Missouri, Forente stater, 64116
    - North Kansas City Hospital
  - Kansas City, Missouri, Forente stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forente stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forente stater, 64108
    - Truman Medical Center
  - Kansas City, Missouri, Forente stater, 64118
    - Heartland Hematology and Oncology Associates Incorporated
  - Kansas City, Missouri, Forente stater, 64111
    - Saint Luke's Cancer Institute
  - Kansas City, Missouri, Forente stater, 64131
    - Kansas City Cancer Center - South
  - Kansas City, Missouri, Forente stater, 64154
    - Kansas City Cancer Centers - North
  - Lee's Summit, Missouri, Forente stater, 64086
    - Saint Luke's East - Lee's Summit
  - Lee's Summit, Missouri, Forente stater, 64064
    - Kansas City Cancer Center-Lee's Summit
  - Liberty, Missouri, Forente stater, 64068
    - Liberty Radiation Oncology Center
  - Rolla, Missouri, Forente stater, 65401
    - Phelps County Regional Medical Center
  - Rolla, Missouri, Forente stater, 65401
    - Saint John's Clinic-Rolla-Cancer and Hematology
  - Saint Joseph, Missouri, Forente stater, 64506
    - Heartland Regional Medical Center
  - Saint Joseph, Missouri, Forente stater, 64507
    - Saint Joseph Oncology Inc
  - Sainte Genevieve, Missouri, Forente stater, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Forente stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forente stater, 65804
    - Mercy Hospital Springfield
  - Springfield, Missouri, Forente stater, 65804
    - Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield
  - St Louis, Missouri, Forente stater, 63110
    - Washington University School of Medicine
  - St Louis, Missouri, Forente stater, 63131
    - Missouri Baptist Medical Center
  - St Louis, Missouri, Forente stater, 63141
    - Comprehensive Cancer Care PC
  - St Louis, Missouri, Forente stater, 63141
    - Saint Louis-Cape Girardeau CCOP
  - St Louis, Missouri, Forente stater, 63109
    - Saint Louis Cancer and Breast Institute-South City
  - St Louis, Missouri, Forente stater, 63110
    - Saint Louis University Hospital
  - St Louis, Missouri, Forente stater, 63141
    - Barnes-Jewish West County Hospital
  - St Louis, Missouri, Forente stater, 63141
    - Saint John's Mercy Medical Center
  - Sullivan, Missouri, Forente stater, 63080
    - Missouri Baptist Sullivan Hospital
  - Sunset Hills, Missouri, Forente stater, 63127
    - Missouri Baptist Outpatient Center-Sunset Hills
- Montana
  - Billings, Montana, Forente stater, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Forente stater, 59101
    - Montana Cancer Consortium CCOP
  - Billings, Montana, Forente stater, 59102
    - Frontier Cancer Center and Blood Institute-Billings
  - Billings, Montana, Forente stater, 59107
    - Billings Clinic Cancer Center
  - Bozeman, Montana, Forente stater, 59715
    - Bozeman Deaconess Hospital
  - Butte, Montana, Forente stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Forente stater, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Forente stater, 59405
    - Benefis Healthcare- Sletten Cancer Institute
  - Great Falls, Montana, Forente stater, 59405
    - Big Sky Oncology
  - Havre, Montana, Forente stater, 59501
    - Northern Montana Hospital
  - Helena, Montana, Forente stater, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Forente stater, 59901
    - Kalispell Regional Medical Center
  - Kalispell, Montana, Forente stater, 59901
    - Glacier Oncology PLLC
  - Kalispell, Montana, Forente stater, 59901
    - Kalispell Medical Oncology
  - Missoula, Montana, Forente stater, 59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula, Montana, Forente stater, 59801
    - Community Medical Hospital
  - Missoula, Montana, Forente stater, 59802
    - Montana Cancer Specialists
- Nebraska
  - Grand Island, Nebraska, Forente stater, 68803
    - Saint Francis Medical Center
  - Kearney, Nebraska, Forente stater, 68845
    - Heartland Hematology and Oncology
  - Kearney, Nebraska, Forente stater, 68847
    - Good Samaritan Hospital
  - Lincoln, Nebraska, Forente stater, 68510
    - Saint Elizabeth Regional Medical Center
  - Omaha, Nebraska, Forente stater, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Forente stater, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Forente stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forente stater, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Forente stater, 68122
    - Hemotology and Oncology Consultants PC
  - Papillion, Nebraska, Forente stater, 68046
    - Midlands Community Hospital
- Nevada
  - Henderson, Nevada, Forente stater, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, Forente stater, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, Forente stater, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, Forente stater, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, Forente stater, 89074
    - 21st Century Oncology - Henderson
  - Las Vegas, Nevada, Forente stater, 89144
    - Summerlin Hospital Medical Center
  - Las Vegas, Nevada, Forente stater, 89109
    - Sunrise Hospital and Medical Center
  - Las Vegas, Nevada, Forente stater, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, Forente stater, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, Forente stater, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, Forente stater, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, Forente stater, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Forente stater, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Forente stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forente stater, 89106
    - Cancer and Blood Specialists-Shadow
  - Las Vegas, Nevada, Forente stater, 89109
    - HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
  - Las Vegas, Nevada, Forente stater, 89113
    - HealthCare Partners Medical Group Oncology/Hematology-San Martin
  - Las Vegas, Nevada, Forente stater, 89121
    - Cancer Therapy and Integrative Medicine
  - Las Vegas, Nevada, Forente stater, 89128
    - Cancer and Blood Specialists-Tenaya
  - Las Vegas, Nevada, Forente stater, 89128
    - HealthCare Partners Medical Group Oncology/Hematology-Tenaya
  - Las Vegas, Nevada, Forente stater, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, Forente stater, 89149
    - HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
  - Las Vegas, Nevada, Forente stater, 89148
    - Cancer and Blood Specialists-Fort Apache
  - Las Vegas, Nevada, Forente stater, 89106
    - Nevada Cancer Research Foundation CCOP
  - Las Vegas, Nevada, Forente stater, 89148
    - 21st Century Oncology - Fort Apache
  - Las Vegas, Nevada, Forente stater, 89182
    - 21st Century Oncology - Vegas Tenaya
  - Las Vegas, Nevada, Forente stater, 89109
    - Children's Specialty Center of Nevada II
  - Las Vegas, Nevada, Forente stater, 89109
    - 21st Century Oncology - Vegas Sunrise
  - Reno, Nevada, Forente stater, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, Forente stater, 89503
    - Saint Mary's Regional Medical Center
  - Reno, Nevada, Forente stater, 89509
    - Radiation Oncology Associates
  - Reno, Nevada, Forente stater, 89503
    - Alpine Hematology-Oncology
  - Reno, Nevada, Forente stater, 89519
    - Reno Oncology Consultants
- New Hampshire
  - Concord, New Hampshire, Forente stater, 03301
    - New Hampshire Oncology-Hematology PA
  - Hooksett, New Hampshire, Forente stater, 03106
    - New Hampshire Oncology Hematology Associates
  - Laconia, New Hampshire, Forente stater, 03246
    - LRGHealthcare-Lakes Region General Hospital
  - Lebanon, New Hampshire, Forente stater, 03756
    - Dartmouth Hitchcock Medical Center
  - Portsmouth, New Hampshire, Forente stater, 03802
    - Portsmouth Regional Hospital
- New Jersey
  - Camden, New Jersey, Forente stater, 08103
    - Cooper Hospital University Medical Center
  - East Orange, New Jersey, Forente stater, 07018-1095
    - Veterans Adminstration New Jersey Health Care System
  - Englewood, New Jersey, Forente stater, 07631
    - Englewood Hospital and Medical Center
  - Freehold, New Jersey, Forente stater, 07728
    - CentraState Medical Center
  - Hamilton, New Jersey, Forente stater, 08690
    - Cancer Institute of New Jersey At Hamilton
  - Livingston, New Jersey, Forente stater, 07039
    - Saint Barnabas Medical Center
  - Morristown, New Jersey, Forente stater, 07962
    - Morristown Memorial Hospital
  - New Brunswick, New Jersey, Forente stater, 08903
    - Rutgers Cancer Institute of New Jersey
  - New Brunswick, New Jersey, Forente stater, 08901
    - Saint Peter's University Hospital
  - New Brunswick, New Jersey, Forente stater, 08903
    - UMDNJ - Robert Wood Johnson University Hospital
  - Sewell, New Jersey, Forente stater, 08080
    - Kennedy Health Systems-Cancer Center
  - Somerville, New Jersey, Forente stater, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Summit, New Jersey, Forente stater, 07902
    - Overlook Hospital
  - Vineland, New Jersey, Forente stater, 08360
    - Inspira Medical Center Vineland
  - Voorhees Township, New Jersey, Forente stater, 08043
    - MD Anderson Cancer Center at Cooper-Voorhees
  - Woodbury, New Jersey, Forente stater, 08096
    - Inspira Medical Center Woodbury
- New Mexico
  - Albuquerque, New Mexico, Forente stater, 87106
    - Hematology Oncology Associates
  - Albuquerque, New Mexico, Forente stater, 87110
    - Presbyterian Kaseman Hospital
  - Santa Fe, New Mexico, Forente stater, 87505
    - New Mexico Cancer Care Associates
- New York
  - Brooklyn, New York, Forente stater, 11209
    - Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus
  - Cooperstown, New York, Forente stater, 13326
    - Mary Imogene Bassett Hospital
  - Glens Falls, New York, Forente stater, 12801
    - Glens Falls Hospital
  - Middletown, New York, Forente stater, 10940
    - Orange Regional Medical Center
  - Mineola, New York, Forente stater, 11501
    - Winthrop University Hospital
  - New York, New York, Forente stater, 10032
    - Columbia University Medical Center
  - New York, New York, Forente stater, 10065
    - Weill Medical College of Cornell University
  - New York, New York, Forente stater, 10016
    - New York University Langone Medical Center
  - Rochester, New York, Forente stater, 14642
    - University of Rochester
  - Rochester, New York, Forente stater, 14621
    - Rochester General Hospital
  - Stony Brook, New York, Forente stater, 11794
    - Stony Brook University Medical Center
  - Syracuse, New York, Forente stater, 13210
    - State University of New York Upstate Medical University
  - White Plains, New York, Forente stater, 10601
    - Dickstein Cancer Treatment Center
- North Carolina
  - Asheville, North Carolina, Forente stater, 28816
    - Hope Women's Cancer Centers-Asheville
  - Asheville, North Carolina, Forente stater, 28801
    - Cancer Care of Western North Carolina
  - Asheville, North Carolina, Forente stater, 28801
    - Mission Hospital-Memorial Campus
  - Asheville, North Carolina, Forente stater, 28803
    - Asheville Hematology-Oncology Associates
  - Asheville, North Carolina, Forente stater, 28801
    - Mountain Radiation Oncology
  - Brevard, North Carolina, Forente stater, 28612
    - Transylvania Regional Hospital
  - Charlotte, North Carolina, Forente stater, 28203
    - Carolinas Medical Center
  - Clinton, North Carolina, Forente stater, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Clinton, North Carolina, Forente stater, 28328
    - Sampson Radiation Oncology
  - Concord, North Carolina, Forente stater, 28025
    - Carolinas Medical Center - Northeast
  - Franklin, North Carolina, Forente stater, 28744
    - Angel Medical Center
  - Goldsboro, North Carolina, Forente stater, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro, North Carolina, Forente stater, 27534
    - Wayne Memorial Hospital
  - Goldsboro, North Carolina, Forente stater, 27534
    - Wayne Radiation Oncology
  - Hendersonville, North Carolina, Forente stater, 28791
    - Margaret R Pardee Memorial Hospital
  - Hendersonville, North Carolina, Forente stater, 28739
    - Hendersonville Hematology and Oncology at Pardee
  - Hendersonville, North Carolina, Forente stater, 28792
    - Park Ridge Hospital Breast Health Center
  - Jacksonville, North Carolina, Forente stater, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Jacksonville, North Carolina, Forente stater, 28546
    - Onslow Memorial Hospital
  - Kernersville, North Carolina, Forente stater, 27284
    - Novant Health Oncology Specialists-Kernersville
  - Kinston, North Carolina, Forente stater, 28501
    - Kinston Medical Specialists PA
  - Lexington, North Carolina, Forente stater, 27295
    - Novant Health Oncology Specialists-Davidson County
  - Marion, North Carolina, Forente stater, 28754
    - McDowell Hospital
  - Monroe, North Carolina, Forente stater, 28112
    - Carolinas Medical Center-Union
  - Mount Airy, North Carolina, Forente stater, 27030
    - Novant Health Oncology Specialists-Mount Airy
  - Pinehurst, North Carolina, Forente stater, 28374
    - FirstHealth of the Carolinas-Moore Regional Hosiptal
  - Shelby, North Carolina, Forente stater, 28150
    - Cleveland Regional Medical Center
  - Spruce Pine, North Carolina, Forente stater, 28777
    - Blue Ridge Regional Hospital
  - Statesville, North Carolina, Forente stater, 28625
    - Novant Health Oncology Specialists-Statesville
  - Wilkesboro, North Carolina, Forente stater, 28659
    - Novant Health Oncology Specialists-Wilkesboro
  - Wilson, North Carolina, Forente stater, 27893
    - Southeastern Medical Oncology Center-Wilson
  - Winston-Salem, North Carolina, Forente stater, 27157
    - Wake Forest University Health Sciences
  - Winston-Salem, North Carolina, Forente stater, 27103
    - Novant Health Forsyth Medical Center
  - Winston-Salem, North Carolina, Forente stater, 27103
    - Novant Health Oncology Specialists
  - Winston-Salem, North Carolina, Forente stater, 27103
    - Winston-Salem Health Care
  - Winston-Salem, North Carolina, Forente stater, 27104
    - Southeast Cancer Control Consortium CCOP
- North Dakota
  - Bismarck, North Dakota, Forente stater, 58501
    - Sanford Bismarck Medical Center
  - Bismarck, North Dakota, Forente stater, 58501
    - Bismarck Cancer Center
  - Bismarck, North Dakota, Forente stater, 58501
    - Mid Dakota Clinic
  - Bismarck, North Dakota, Forente stater, 58501
    - Saint Alexius Medical Center
  - Fargo, North Dakota, Forente stater, 58122
    - Sanford Clinic North-Fargo
  - Fargo, North Dakota, Forente stater, 58122
    - Sanford Medical Center-Fargo
  - Fargo, North Dakota, Forente stater, 58122
    - Roger Maris Cancer Center
  - Grand Forks, North Dakota, Forente stater, 58201
    - Altru Cancer Center
- Ohio
  - Akron, Ohio, Forente stater, 44304
    - Summa Akron City Hospital/Cooper Cancer Center
  - Akron, Ohio, Forente stater, 44307
    - Akron General Medical Center
  - Barberton, Ohio, Forente stater, 44203
    - Summa Barberton Hospital
  - Bellefontaine, Ohio, Forente stater, 43311
    - Mary Rutan Hospital
  - Belpre, Ohio, Forente stater, 45714
    - Strecker Cancer Center-Belpre
  - Bowling Green, Ohio, Forente stater, 43402
    - Toledo Clinic Cancer Centers-Bowling Green
  - Canton, Ohio, Forente stater, 44710
    - Aultman Health Foundation
  - Centerville, Ohio, Forente stater, 45459
    - Miami Valley Hospital South
  - Chillicothe, Ohio, Forente stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forente stater, 45267
    - University of Cincinnati
  - Cincinnati, Ohio, Forente stater, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, Forente stater, 45242
    - Bethesda North Hospital
  - Cincinnati, Ohio, Forente stater, 45242
    - Oncology Hematology Care Inc-Blue Ash
  - Cincinnati, Ohio, Forente stater, 45211
    - Oncology Hematology Care Inc-Mercy West
  - Cincinnati, Ohio, Forente stater, 45230
    - Oncology Hematology Care Inc - Anderson
  - Cincinnati, Ohio, Forente stater, 45247
    - TriHealth Cancer Institute-Westside
  - Cincinnati, Ohio, Forente stater, 45255
    - TriHealth Cancer Institute-Anderson
  - Cincinnati, Ohio, Forente stater, 45219
    - Oncology and Hematology Care Inc-Taft
  - Cincinnati, Ohio, Forente stater, 45236
    - Oncology Hematology Care Inc - Kenwood
  - Cleveland, Ohio, Forente stater, 44109
    - MetroHealth Medical Center
  - Clyde, Ohio, Forente stater, 43410
    - North Coast Cancer Care-Clyde
  - Columbus, Ohio, Forente stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forente stater, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Forente stater, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Forente stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forente stater, 43213
    - Mount Carmel East Hospital
  - Columbus, Ohio, Forente stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forente stater, 43222
    - Mount Carmel Health Center West
  - Columbus, Ohio, Forente stater, 43215
    - Columbus CCOP
  - Dayton, Ohio, Forente stater, 45406
    - Good Samaritan Hospital - Dayton
  - Dayton, Ohio, Forente stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forente stater, 45415
    - Samaritan North Health Center
  - Dayton, Ohio, Forente stater, 45405
    - Grandview Hospital
  - Dayton, Ohio, Forente stater, 45420
    - Dayton CCOP
  - Delaware, Ohio, Forente stater, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Forente stater, 43015
    - Delaware Radiation Oncology
  - Delaware, Ohio, Forente stater, 43015
    - Grady Memorial Hospital
  - Elyria, Ohio, Forente stater, 44035
    - Mercy Cancer Center-Elyria
  - Elyria, Ohio, Forente stater, 44035
    - Hematology Oncology Center Incorporated
  - Fairfield, Ohio, Forente stater, 45014
    - Oncology Hematology Care Inc-Healthplex
  - Findlay, Ohio, Forente stater, 45840
    - Blanchard Valley Hospital
  - Franklin, Ohio, Forente stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Greenville, Ohio, Forente stater, 45331
    - Wayne Hospital
  - Kettering, Ohio, Forente stater, 45429
    - Kettering Medical Center
  - Lancaster, Ohio, Forente stater, 43130
    - Fairfield Medical Center
  - Lancaster, Ohio, Forente stater, 43130
    - Lancaster Radiation Oncology
  - Lima, Ohio, Forente stater, 45804
    - Lima Memorial Hospital
  - Marietta, Ohio, Forente stater, 45750
    - Marietta Memorial Hospital
  - Maumee, Ohio, Forente stater, 43537
    - Toledo Clinic Cancer Centers-Maumee
  - Maumee, Ohio, Forente stater, 43537
    - Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
  - Medina, Ohio, Forente stater, 44256
    - Summa Health Center at Lake Medina
  - Mount Vernon, Ohio, Forente stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forente stater, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, Forente stater, 43055
    - Newark Radiation Oncology
  - Norwalk, Ohio, Forente stater, 44857
    - Fisher-Titus Medical Center
  - Oregon, Ohio, Forente stater, 43616
    - Saint Charles Hospital
  - Oregon, Ohio, Forente stater, 43616
    - Toledo Clinic Cancer Centers-Oregon
  - Portsmouth, Ohio, Forente stater, 45662
    - Southern Ohio Medical Center
  - Sandusky, Ohio, Forente stater, 44870
    - North Coast Cancer Care
  - Springfield, Ohio, Forente stater, 45505
    - Springfield Regional Medical Center
  - Steubenville, Ohio, Forente stater, 43952
    - Trinity's Tony Teramana Cancer Center
  - Sylvania, Ohio, Forente stater, 43560
    - Flower Hospital
  - Tiffin, Ohio, Forente stater, 44883
    - Mercy Hospital of Tiffin
  - Toledo, Ohio, Forente stater, 43608
    - Saint Vincent Mercy Medical Center
  - Toledo, Ohio, Forente stater, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Toledo, Ohio, Forente stater, 43614
    - University of Toledo
  - Toledo, Ohio, Forente stater, 43617
    - Toledo Community Hospital Oncology Program CCOP
  - Toledo, Ohio, Forente stater, 43606
    - The Toledo Hospital/Toledo Children's Hospital
  - Toledo, Ohio, Forente stater, 43623
    - Mercy Saint Anne Hospital
  - Troy, Ohio, Forente stater, 45373
    - Upper Valley Medical Center
  - Wauseon, Ohio, Forente stater, 43567
    - Fulton County Health Center
  - West Chester, Ohio, Forente stater, 45069
    - University Pointe
  - Westerville, Ohio, Forente stater, 43081
    - Saint Ann's Hospital
  - Wilmington, Ohio, Forente stater, 45177
    - Clinton Memorial Hospital
  - Wright-Patterson Air Force Base, Ohio, Forente stater, 45433-5529
    - Wright-Patterson Medical Center
  - Xenia, Ohio, Forente stater, 45385
    - Greene Memorial Hospital
  - Zanesville, Ohio, Forente stater, 43701
    - Genesis HealthCare System
- Oklahoma
  - Lawton, Oklahoma, Forente stater, 73505
    - Cancer Centers of Southwest Oklahoma Research
  - Norman, Oklahoma, Forente stater, 73071
    - Cancer Care Associates-Norman
  - Oklahoma City, Oklahoma, Forente stater, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Forente stater, 73120
    - Cancer Care Associates-Mercy
  - Tulsa, Oklahoma, Forente stater, 74146
    - Tulsa Cancer Institute
  - Tulsa, Oklahoma, Forente stater, 74136
    - Natalie Warren Bryant Cancer Center at Saint Francis
  - Tulsa, Oklahoma, Forente stater, 74104
    - Oklahoma Oncology Inc
  - Tulsa, Oklahoma, Forente stater, 74136
    - Warren Cancer Research Foundation
- Oregon
  - Bend, Oregon, Forente stater, 97701
    - Saint Charles Medical Center-Bend
  - Coos Bay, Oregon, Forente stater, 97420
    - Bay Area Hospital
  - Grants Pass, Oregon, Forente stater, 97527
    - Three Rivers Community Hospital
  - Gresham, Oregon, Forente stater, 97030
    - Legacy Mount Hood Medical Center
  - Medford, Oregon, Forente stater, 97504
    - Asante Health System
  - Medford, Oregon, Forente stater, 97504
    - Providence Medford Medical Center
  - Medford, Oregon, Forente stater, 97504
    - Rogue Valley Medical Center
  - Portland, Oregon, Forente stater, 97239
    - Oregon Health and Science University
  - Portland, Oregon, Forente stater, 97210
    - Legacy Good Samaritan Hospital and Medical Center
  - Portland, Oregon, Forente stater, 97227
    - Kaiser Permanente
  - Portland, Oregon, Forente stater, 97227
    - Legacy Emanuel Hospital and Health Center
  - Salem, Oregon, Forente stater, 97301
    - Salem Hospital
  - Tualatin, Oregon, Forente stater, 97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Abington, Pennsylvania, Forente stater, 19001
    - Abington Memorial Hospital
  - Allentown, Pennsylvania, Forente stater, 18105
    - LeHigh Valley Hospital
  - Beaver, Pennsylvania, Forente stater, 15009
    - UPMC - HVHS Cancer Center at Heritage Valley Beaver
  - Bethlehem, Pennsylvania, Forente stater, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bryn Mawr, Pennsylvania, Forente stater, 19010
    - Bryn Mawr Hospital
  - Butler, Pennsylvania, Forente stater, 16001
    - Butler Memorial Hospital
  - Clairton, Pennsylvania, Forente stater, 15025
    - UPMC Cancer Center at Jefferson Regional Medical Center
  - Danville, Pennsylvania, Forente stater, 17822
    - Geisinger Medical Center
  - Doylestown, Pennsylvania, Forente stater, 18901
    - Doylestown Hospital
  - Drexel Hill, Pennsylvania, Forente stater, 19026
    - Delaware County Memorial Hospital
  - Easton, Pennsylvania, Forente stater, 18042
    - Easton Hospital
  - Greensburg, Pennsylvania, Forente stater, 15601
    - UPMC Cancer Centers - Arnold Palmer Pavilion
  - Hazleton, Pennsylvania, Forente stater, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hershey, Pennsylvania, Forente stater, 17033-0850
    - Penn State Milton S Hershey Medical Center
  - Johnstown, Pennsylvania, Forente stater, 15901
    - UPMC-Johnstown/John P. Murtha Regional Cancer Center
  - Lancaster, Pennsylvania, Forente stater, 17604
    - Lancaster General Hospital
  - Lewisburg, Pennsylvania, Forente stater, 17837
    - Geisinger Medical Oncology at Evangelical Community Hospital
  - Lewistown, Pennsylvania, Forente stater, 17044
    - Lewistown Hospital
  - McKeesport, Pennsylvania, Forente stater, 15132
    - UPMC Cancer Center at UPMC McKeesport
  - Moon Township, Pennsylvania, Forente stater, 15108
    - UPMC-Coraopolis/Heritage Valley Radiation Oncology
  - Paoli, Pennsylvania, Forente stater, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forente stater, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forente stater, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Forente stater, 19104
    - University of Pennsylvania/Abramson Cancer Center
  - Philadelphia, Pennsylvania, Forente stater, 19140
    - Temple University Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15213
    - Magee-Womens Hospital of UPMC
  - Pittsburgh, Pennsylvania, Forente stater, 15232
    - University of Pittsburgh
  - Pittsburgh, Pennsylvania, Forente stater, 15232
    - UPMC-Shadyside Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15215
    - UPMC-Saint Margaret
  - Pittsburgh, Pennsylvania, Forente stater, 15237
    - UPMC-Passavant Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15243
    - UPMC-Saint Clair Hospital Cancer Center
  - Pittsburgh, Pennsylvania, Forente stater, 15213
    - University of Pittsburgh Medical Center-Presbyterian Hospital
  - Pottstown, Pennsylvania, Forente stater, 19464
    - Pottstown Memorial Medical Center
  - Pottsville, Pennsylvania, Forente stater, 17901
    - Geisinger Medical Oncology-Pottsville
  - Sayre, Pennsylvania, Forente stater, 18840
    - Guthrie Medical Group PC-Robert Packer Hospital
  - Sellersville, Pennsylvania, Forente stater, 18960
    - Grand View Hospital
  - Seneca, Pennsylvania, Forente stater, 16346
    - UPMC Cancer Center at UPMC Northwest
  - State College, Pennsylvania, Forente stater, 16801
    - Geisinger Medical Group
  - Uniontown, Pennsylvania, Forente stater, 15401
    - UPMC-Uniontown/Robert E. Eberly Pavilion
  - Washington, Pennsylvania, Forente stater, 15301
    - Washington Hospital
  - West Chester, Pennsylvania, Forente stater, 19380
    - Chester County Hospital
  - West Reading, Pennsylvania, Forente stater, 19611
    - Reading Hospital
  - Wilkes-Barre, Pennsylvania, Forente stater, 18711
    - Geisinger Wyoming Valley
  - Williamsport, Pennsylvania, Forente stater, 17701
    - Susquehanna Cancer Center
  - Wynnewood, Pennsylvania, Forente stater, 19096
    - Lankenau Medical Center
  - Wynnewood, Pennsylvania, Forente stater, 19096
    - Mainline Health CCOP
- South Carolina
  - Anderson, South Carolina, Forente stater, 29621
    - AnMed Health Cancer Center
  - Anderson, South Carolina, Forente stater, 29621
    - AnMed Health Hospital
  - Charleston, South Carolina, Forente stater, 29425
    - Medical University of South Carolina
  - Charleston, South Carolina, Forente stater, 29401
    - Roper Hospital
  - Charleston, South Carolina, Forente stater, 29403
    - Charleston Hematology Oncology Associates-Roper
  - Charleston, South Carolina, Forente stater, 29414
    - Charleston Hematology Oncology Associates PA-St. Francis
  - Charleston, South Carolina, Forente stater, 29414
    - Lowcountry Hematology Oncology PA-West Ashley
  - Charleston, South Carolina, Forente stater, 29406
    - Lowcountry Hematology Oncology PA-Charleston
  - Easley, South Carolina, Forente stater, 29640
    - Greenville Health System Cancer Institute-Easley
  - Florence, South Carolina, Forente stater, 29506
    - McLeod Regional Medical Center
  - Greenville, South Carolina, Forente stater, 29607
    - Saint Francis Cancer Center
  - Greenville, South Carolina, Forente stater, 29601
    - Saint Francis Hospital
  - Greenville, South Carolina, Forente stater, 29605
    - Greenville Health System Cancer Institute-Andrews
  - Greenville, South Carolina, Forente stater, 29605
    - Greenville Health System Cancer Institute-Faris
  - Greenville, South Carolina, Forente stater, 29605
    - Greenville Memorial Hospital
  - Greenville, South Carolina, Forente stater, 29615
    - Greenville Health System Cancer Institute-Eastside
  - Greenville, South Carolina, Forente stater, 29605
    - Greenville Health System Cancer Institute-Butternut
  - Greenwood, South Carolina, Forente stater, 29646
    - Self Regional Healthcare
  - Greer, South Carolina, Forente stater, 29651
    - Gibbs Cancer Center-Pelham
  - Greer, South Carolina, Forente stater, 29650
    - Greenville Health System Cancer Institute-Greer
  - Lancaster, South Carolina, Forente stater, 29720
    - Carolina Blood and Cancer Care Associates PA-Lancaster
  - Mt. Pleasant, South Carolina, Forente stater, 29464
    - Lowcountry Hematology Oncology PA-Mount Pleasant
  - Rock Hill, South Carolina, Forente stater, 29732
    - Carolina Blood and Cancer Care Associates PA
  - Seneca, South Carolina, Forente stater, 29672
    - Greenville Health System Cancer Institute-Seneca
  - Spartanburg, South Carolina, Forente stater, 29307
    - Greenville Health System Cancer Institute-Spartanburg
  - Spartanburg, South Carolina, Forente stater, 29303
    - Spartanburg Regional Medical Center
  - Spartanburg, South Carolina, Forente stater, 29303
    - Upstate Carolina CCOP
- South Dakota
  - Aberdeen, South Dakota, Forente stater, 57401
    - Conklin Regional Cancer Center
  - Rapid City, South Dakota, Forente stater, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Forente stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forente stater, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Forente stater, 57104
    - Sanford Cancer Center-Oncology Clinic
  - Sioux Falls, South Dakota, Forente stater, 57105
    - Medical X-Ray Center
- Tennessee
  - Bristol, Tennessee, Forente stater, 37620
    - Wellmont Medical Associates Oncology and Hematology-Bristol
  - Bristol, Tennessee, Forente stater, 37620
    - Wellmont Bristol Regional Medical Center
  - Chattanooga, Tennessee, Forente stater, 37404
    - Memorial Hospital
  - Chattanooga, Tennessee, Forente stater, 37403
    - Erlanger Medical Center
  - Franklin, Tennessee, Forente stater, 37067
    - Vanderbilt-Ingram Cancer Center Cool Springs
  - Hixson, Tennessee, Forente stater, 37343
    - Pulmonary Medicine Center of Chattanooga-Hixson
  - Kingsport, Tennessee, Forente stater, 37660
    - Wellmont Holston Valley Hospital and Medical Center
  - Kingsport, Tennessee, Forente stater, 37660
    - Wellmont Medical Associates Oncology and Hematology-Kingsport
  - Knoxville, Tennessee, Forente stater, 37920
    - University of Tennessee - Knoxville
  - Memphis, Tennessee, Forente stater, 38163
    - University of Tennessee Health Science Center
  - Nashville, Tennessee, Forente stater, 37232
    - Vanderbilt-Ingram Cancer Center
  - Nashville, Tennessee, Forente stater, 37208
    - Meharry Medical College
  - Ooltewah, Tennessee, Forente stater, 37363
    - Memorial GYN Plus
- Texas
  - Galveston, Texas, Forente stater, 77555-0565
    - University of Texas Medical Branch at Galveston
  - Houston, Texas, Forente stater, 77030
    - Baylor College of Medicine
  - Houston, Texas, Forente stater, 77030
    - Ben Taub General Hospital
  - Houston, Texas, Forente stater, 77030
    - Saint Luke's Episcopal Hospital
  - Houston, Texas, Forente stater, 77030
    - Veterans Administration Medical Center
  - League City, Texas, Forente stater, 77573
    - UTMB Cancer Center at Victory Lakes
  - Lubbock, Texas, Forente stater, 79410
    - Covenant Medical Center-Lakeside
  - San Antonio, Texas, Forente stater, 78229
    - University Hospital
  - San Antonio, Texas, Forente stater, 78229
    - University of Texas Health Science Center at San Antonio
  - San Antonio, Texas, Forente stater, 78229
    - Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
  - San Antonio, Texas, Forente stater, 78209
    - Audie L Murphy Veterans Affairs Hospital
  - Temple, Texas, Forente stater, 76508
    - Scott and White Memorial Hospital
- Utah
  - Salt Lake City, Utah, Forente stater, 84112
    - Huntsman Cancer Institute/University of Utah
- Virginia
  - Danville, Virginia, Forente stater, 24541
    - Danville Regional Medical Center
  - Danville, Virginia, Forente stater, 24541
    - Danville Hematology Oncology
  - Fredericksburg, Virginia, Forente stater, 22401
    - Fredericksburg Oncology Inc
  - Fredericksburg, Virginia, Forente stater, 22408
    - Hematology Oncology Associates of Fredericksburg Inc
  - Lynchburg, Virginia, Forente stater, 24501
    - Lynchburg Hematology-Oncology Clinic
  - Midlothian, Virginia, Forente stater, 23114
    - Bon Secours Saint Francis Medical Center
  - Norton, Virginia, Forente stater, 24273
    - Southwest VA Regional Cancer Center
  - Richmond, Virginia, Forente stater, 23298
    - Virginia Commonwealth University/Massey Cancer Center
  - Richmond, Virginia, Forente stater, 23230
    - Virginia Cancer Institute
  - Richmond, Virginia, Forente stater, 23226
    - Bon Secours Saint Mary's Hospital
  - South Hill, Virginia, Forente stater, 23970
    - Community Memorial Health Center
  - Winchester, Virginia, Forente stater, 22601
    - Shenandoah Oncology Associates PC
- Washington
  - Anacortes, Washington, Forente stater, 98221
    - Cancer Care Center at Island Hospital
  - Auburn, Washington, Forente stater, 98001
    - Auburn Regional Medical Center
  - Bellevue, Washington, Forente stater, 98004
    - Overlake Hospital Medical Center
  - Bellingham, Washington, Forente stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Bremerton, Washington, Forente stater, 98310
    - Harrison HealthPartners Hematology and Oncology-Bremerton
  - Burien, Washington, Forente stater, 98166
    - Highline Medical Center-Main Campus
  - Centralia, Washington, Forente stater, 98531
    - Providence Regional Cancer System-Centralia
  - Edmonds, Washington, Forente stater, 98026
    - Swedish Medical Center-Edmonds
  - Enumclaw, Washington, Forente stater, 98022
    - Saint Elizabeth Hospital
  - Everett, Washington, Forente stater, 98201
    - Providence Regional Cancer Partnership
  - Federal Way, Washington, Forente stater, 98003
    - Saint Francis Hospital
  - Issaquah, Washington, Forente stater, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Forente stater, 99336
    - Kadlec Clinic Hematology and Oncology
  - Kirkland, Washington, Forente stater, 98034
    - Seattle Cancer Care Alliance at EvergreenHealth
  - Kirkland, Washington, Forente stater, 98033
    - EvergreenHealth Medical Center
  - Lacey, Washington, Forente stater, 98503
    - Providence Regional Cancer System-Lacey
  - Lakewood, Washington, Forente stater, 98499
    - Saint Clare Hospital
  - Mount Vernon, Washington, Forente stater, 98274
    - Skagit Valley Hospital
  - Olympia, Washington, Forente stater, 98506-5166
    - Providence - Saint Peter Hospital
  - Olympia, Washington, Forente stater, 98507
    - Capital Medical Center
  - Poulsbo, Washington, Forente stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Puyallup, Washington, Forente stater, 98372
    - MultiCare Good Samaritan Hospital
  - Seattle, Washington, Forente stater, 98195
    - University of Washington Medical Center
  - Seattle, Washington, Forente stater, 98109
    - Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
  - Seattle, Washington, Forente stater, 98104
    - Harborview Medical Center
  - Seattle, Washington, Forente stater, 98101
    - Virginia Mason Medical Center
  - Seattle, Washington, Forente stater, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Forente stater, 98104
    - Minor and James Medical PLLC
  - Seattle, Washington, Forente stater, 98112
    - Group Health Cooperative-Seattle
  - Seattle, Washington, Forente stater, 98122-4307
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forente stater, 98122
    - The Polyclinic
  - Seattle, Washington, Forente stater, 98104
    - Pacific Medical Center-First Hill
  - Seattle, Washington, Forente stater, 98101
    - Virginia Mason CCOP
  - Seattle, Washington, Forente stater, 98109
    - Group Health
  - Sedro-Woolley, Washington, Forente stater, 98284
    - United General Hospital
  - Spokane, Washington, Forente stater, 99218
    - Evergreen Hematology and Oncology PS
  - Spokane, Washington, Forente stater, 99202
    - Cancer Care Northwest - Spokane South
  - Spokane, Washington, Forente stater, 99220
    - Rockwood Clinic
  - Tacoma, Washington, Forente stater, 98405
    - Northwest Medical Specialties PLLC
  - Tacoma, Washington, Forente stater, 98431
    - Madigan Army Medical Center
  - Tacoma, Washington, Forente stater, 98405
    - Franciscan Research Center-Northwest Medical Plaza
  - Tacoma, Washington, Forente stater, 98405
    - MultiCare Allenmore Hospital
  - Tacoma, Washington, Forente stater, 98405
    - Saint Joseph Medical Center
  - Tacoma, Washington, Forente stater, 98415
    - MultiCare Health System
  - Tacoma, Washington, Forente stater, 98405
    - Northwest CCOP
  - Vancouver, Washington, Forente stater, 98686
    - Legacy Salmon Creek Hospital
  - Walla Walla, Washington, Forente stater, 99362
    - Providence Saint Mary Regional Cancer Center
  - Wenatchee, Washington, Forente stater, 98801
    - Wenatchee Valley Medical Center
  - Yakima, Washington, Forente stater, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
- West Virginia
  - Charleston, West Virginia, Forente stater, 25304
    - West Virginia University Charleston
  - Huntington, West Virginia, Forente stater, 25701
    - Edwards Comprehensive Cancer Center
  - Huntington, West Virginia, Forente stater, 25702
    - Saint Mary's Medical Center
- Wisconsin
  - Antigo, Wisconsin, Forente stater, 54409
    - Langlade Hospital and Cancer Center
  - Appleton, Wisconsin, Forente stater, 54911
    - Fox Valley Hematology and Oncology
  - Burlington, Wisconsin, Forente stater, 53105
    - Aurora Cancer Care-Burlington
  - Eau Claire, Wisconsin, Forente stater, 54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Eau Claire, Wisconsin, Forente stater, 54701
    - Sacred Heart Hospital
  - Elkhorn, Wisconsin, Forente stater, 53121
    - Aurora Cancer Care-Southern Lakes
  - Fond du Lac, Wisconsin, Forente stater, 54937
    - Aurora Health Center-Fond du Lac
  - Grafton, Wisconsin, Forente stater, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Forente stater, 54301
    - Saint Vincent Hospital
  - Green Bay, Wisconsin, Forente stater, 54303
    - Green Bay Oncology Limited at Saint Mary's Hospital
  - Green Bay, Wisconsin, Forente stater, 54303
    - Saint Mary's Hospital
  - Green Bay, Wisconsin, Forente stater, 54301-3526
    - Green Bay Oncology at Saint Vincent Hospital
  - Green Bay, Wisconsin, Forente stater, 54311-6519
    - Aurora BayCare Medical Center
  - Johnson Creek, Wisconsin, Forente stater, 53038
    - UW Cancer Center Johnson Creek
  - Kenosha, Wisconsin, Forente stater, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Forente stater, 54601
    - Gundersen Lutheran Medical Center
  - Madison, Wisconsin, Forente stater, 53792
    - University of Wisconsin Hospital and Clinics
  - Manitowoc, Wisconsin, Forente stater, 54221
    - Holy Family Memorial Hospital
  - Marinette, Wisconsin, Forente stater, 54143
    - Bay Area Medical Center
  - Marinette, Wisconsin, Forente stater, 54143
    - Vince Lombardi Cancer Clinic-Marinette
  - Marshfield, Wisconsin, Forente stater, 54449
    - Marshfield Clinic
  - Marshfield, Wisconsin, Forente stater, 54449
    - Saint Joseph's Hospital
  - Menomonee Falls, Wisconsin, Forente stater, 53051
    - Community Memorial Hospital
  - Menomonee Falls, Wisconsin, Forente stater, 53051
    - Aurora Advanced Healthcare Inc-Menomonee Falls
  - Milwaukee, Wisconsin, Forente stater, 53226
    - Froedtert and The Medical College of Wisconsin
  - Milwaukee, Wisconsin, Forente stater, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Forente stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forente stater, 53233
    - Aurora Sinai Medical Center
  - Milwaukee, Wisconsin, Forente stater, 53210
    - Wheaton Franciscan Healthcare - Saint Joseph
  - Milwaukee, Wisconsin, Forente stater, 53215
    - Aurora Cancer Care-Milwaukee South
  - Minocqua, Wisconsin, Forente stater, 54548
    - Marshfield Clinic-Minocqua Center
  - Mukwonago, Wisconsin, Forente stater, 53149
    - D N Greenwald Center
  - New Richmond, Wisconsin, Forente stater, 54017
    - Cancer Center of Western Wisconsin
  - Oconomowoc, Wisconsin, Forente stater, 53066-3896
    - Oconomowoc Memorial Hospital-ProHealth Care Inc
  - Oconto Falls, Wisconsin, Forente stater, 54154
    - Green Bay Oncology - Oconto Falls
  - Oshkosh, Wisconsin, Forente stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forente stater, 53406-5661
    - Aurora Cancer Care-Racine
  - Rhinelander, Wisconsin, Forente stater, 54501
    - Saint Mary's Hospital
  - Rhinelander, Wisconsin, Forente stater, 54501
    - Marshfield Clinic at James Beck Cancer Center
  - Rice Lake, Wisconsin, Forente stater, 54868
    - Marshfield Clinic-Rice Lake Center
  - Sheboygan, Wisconsin, Forente stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Sheboygan, Wisconsin, Forente stater, 53081
    - Saint Nicholas Hospital
  - Stevens Point, Wisconsin, Forente stater, 54481
    - Saint Michael's Hospital
  - Stevens Point, Wisconsin, Forente stater, 54481
    - Marshfield Clinic Cancer Care at Saint Michael's Hospital
  - Sturgeon Bay, Wisconsin, Forente stater, 54235
    - Green Bay Oncology - Sturgeon Bay
  - Summit, Wisconsin, Forente stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forente stater, 54241
    - Vince Lombardi Cancer Clinic
  - Waukesha, Wisconsin, Forente stater, 53188
    - Aurora Cancer Care-Waukesha
  - Waukesha, Wisconsin, Forente stater, 53188
    - Waukesha Memorial Hospital - ProHealth Care
  - Wausau, Wisconsin, Forente stater, 54401
    - Aspirus Regional Cancer Center
  - Wauwatosa, Wisconsin, Forente stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - West Allis, Wisconsin, Forente stater, 53227
    - Aurora West Allis Medical Center
  - West Bend, Wisconsin, Forente stater, 53095
    - The Alyce and Elmore Kraemer Cancer Care Center
  - Weston, Wisconsin, Forente stater, 54476
    - Diagnostic and Treatment Center
  - Weston, Wisconsin, Forente stater, 54476
    - Marshfield Clinic - Weston Center
  - Wisconsin Rapids, Wisconsin, Forente stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
  - Wisconsin Rapids, Wisconsin, Forente stater, 54494
    - Riverview Hospital
- Wyoming
  - Casper, Wyoming, Forente stater, 82609
    - Rocky Mountain Oncology
  - Cheyenne, Wyoming, Forente stater, 82001
    - Cheyenne Regional Medical Center-West
  - Cody, Wyoming, Forente stater, 82414
    - Big Horn Basin Cancer Center
  - Cody, Wyoming, Forente stater, 82414
    - Billings Clinic-Cody
  - Sheridan, Wyoming, Forente stater, 82801
    - Welch Cancer Center
Puerto Rico
- - San Juan, Puerto Rico, 00936
    - San Juan City Hospital

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år til 120 år (Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Beskrivelse

SYKDOMENS KARAKTERISTIKA:

Histologisk eller cytologisk bekreftet nyrecellekarsinom
- Tøm celle eller ikke-klar celle tillatt
  - Ingen sykdom i samlekanalen eller medullært karsinom
- Vurderes patologisk enten middels høyrisiko eller svært høyrisikosykdom
- Ingen historie med fjernmetastaser
- Pasienter med mikrovaskulær invasjon av nyrevenen uansett grad eller stadium (så lenge som M0) er kvalifisert
Har gjennomgått en fullstendig kirurgisk reseksjon (radikal nefrektomi eller partiell nefrektomi) inkludert fjerning av alle klinisk positive noder
- Kirurgiske marginer må være negative
  - Pasienter med positive nyrevenemarginer er kvalifiserte med mindre det er invasjon av nyreveneveggen ved kanten (forutsatt at ingen andre marginer er positive)
- Pasienter må registreres innen 84 dager etter datoen for første kirurgiske reseksjon av den første svulsten
Ingen tegn på gjenværende eller metastatisk nyrecellekreft på CT-skanning av bryst, mage og bekken (alle med oral og IV kontrast) utført etter nefrektomi og innen 28 dager før registrering
- MR-skanning av mage og bekken med gadolinium og en ikke-kontrast-CT-skanning av brystet kan erstattes hvis pasienten ikke er i stand til å ha CT-skanning med IV-kontrast

PASIENT KARAKTERISTIKA:

Zubrod prestasjonsstatus 0-1
ANC ≥ 1500/mm^3
Blodplateantall ≥ 100 000/mm^3
Serumkreatinin ≤ 2,0 ganger øvre normalgrense (ULN) ELLER beregnet kreatininclearance ≥ 30 ml/min.
Bilirubin ≤ 1,5 ganger ULN
SGOT og SGPT ≤ 2,5 ganger ULN
Ikke gravid eller ammende
Fertile pasienter må bruke effektiv prevensjon under og i opptil 8 uker etter avsluttet studiebehandling
Kunne ta orale medisiner
Pasienter må ikke ha noen av følgende:
- NYHA klasse III-IV hjertesykdom (dvs. pasienter med hjertesykdom som resulterer i markert begrensning av fysisk aktivitet eller som resulterer i manglende evne til å utføre fysisk aktivitet uten ubehag)
- Ustabil angina pectoris
- Hjerteinfarkt de siste 6 månedene
- Alvorlig ukontrollert hjertearytmi
Pasienter må IKKE ha leversykdom som skrumplever eller alvorlig nedsatt leverfunksjon (Child-Pugh klasse C)
HBV- og HCV-testing er nødvendig ved screening for alle pasienter med positiv sykehistorie basert på risikofaktorer og/eller bekreftelse på tidligere HBV/HCV-infeksjon
Må kunne ta orale medisiner
Ingen svekkelse av gastrointestinal funksjon eller gastrointestinal sykdom som signifikant kan endre absorpsjonen av everolimus (f.eks. ulcerøs sykdom, ukontrollert kvalme, oppkast, diaré, malabsorpsjonssyndrom eller tynntarmsreseksjon)
Ingen kjent historie med HIV-seropositivitet
Ingen kjent ukontrollert, underliggende lungesykdom (spirometri og DLCO ≤ 50 % av antatt ELLER oksygenmetning ≤ 88 % i hvile på romluft)
Ingen ukontrollert hyperlipidemi (fastende serumkolesterol > 300 mg/dL OG fastende triglyserider > 2,5 ganger ULN) oppnådd innen 28 dager før registrering
- Optimal lipidkontroll må oppnås før registrering og overvåkes under protokollbehandling
Ingen ukontrollert diabetes mellitus (definert ved fastende serumglukose > 1,5 ganger ULN) oppnådd innen 28 dager før registrering.
- Optimal glukosekontroll må oppnås før registrering og overvåkes under protokollbehandling
Ingen tidligere maligniteter bortsett fra noen av følgende:
- Tilstrekkelig behandlet hudkreft i basalceller eller plateepitel
- In situ livmorhalskreft
- Tilstrekkelig behandlet stadium I eller stadium II kreft som pasienten for øyeblikket er i fullstendig remisjon fra
- Enhver annen kreftsykdom som pasienten har vært sykdomsfri fra i 5 år
Ingen kjent overfølsomhet overfor everolimus eller andre rapamyciner (sirolimus, temsirolimus) eller hjelpestoffene deres
Ingen kontraindikasjoner for å få enten IV jodbasert kontrast eller gadolinium

FØR SAMTIDIG TERAPI:

Se Sykdomskarakteristikker
Pasienter må ha kommet seg etter eventuelle operasjonsrelaterte komplikasjoner
Ingen tidligere kreftbehandling for nyrecellekarsinom inkludert systemisk terapi i adjuvant eller neoadjuvant setting, immunterapi, undersøkelsesterapi, kirurgisk metastasektomi eller strålebehandling
Mer enn 14 dager siden tidligere og ingen samtidige sterke CYP3A4-hemmere (dvs. ketokonazol, itrakonazol, vorikonazol, posakonazol, fluvoksamin, nefazodon, nelfinavir eller ritonavir) eller sterke CYP3A4-induktorer (dvs.
Mer enn 7 dager siden forrige og ingen samtidige levende vaksiner
Ingen andre samtidige antikreftmidler inkludert undersøkelsesmidler
Ingen samtidig kronisk behandling med systemiske steroider eller annet immunsuppressivt middel
- Aktuelle eller inhalerte kortikosteroider er tillatt

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Primært formål: Behandling
Tildeling: Randomisert
Intervensjonsmodell: Parallell tildeling
Masking: Trippel

Antall våpen

Våpen og intervensjoner

Deltakergruppe / Arm	Intervensjon / Behandling
Eksperimentell: Arm I Pasienter får oral everolimus én gang daglig på dag 1-42. Behandlingen gjentas hver 6. uke i 9 kurer i fravær av sykdomsprogresjon eller uakseptabel toksisitet.	Legemiddel: everolimus Gis muntlig
Placebo komparator: Arm II Pasienter får oral placebo én gang daglig på dag 1-42. Behandlingen gjentas hver 6. uke i 9 kurer i fravær av sykdomsprogresjon eller uakseptabel toksisitet.	Annen: placebo Gis muntlig

Hva måler studien?

Primære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
5-års gjentaksfri overlevelse (RFS) Tidsramme: 5 år fra registrering	For å sammenligne 5-års residivfri overlevelse hos nyrekarsinom deltakere tilfeldig fordelt til 54 uker med everolimus versus 54 uker med placebo etter nefrektomi eller delvis nefrektomi. Residivfri overlevelse er definert som Fra registreringsdato til dato for første dokumentasjon på gjentakelse eller død på grunn av en hvilken som helst årsak. Deltakere sist kjent for å være i live og gjentakelsesfrie blir sensurert på datoen for siste kontakt. Residiv er definert som positiv cytologi eller biopsi og/eller progressivt forstørrende fast masse som påvist ved CT- eller MR-skanning.	5 år fra registrering

Sekundære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
5-års total overlevelse (OS) Tidsramme: 5 år fra registrering	For å sammenligne 5-års total overlevelse hos de pasientene som ble randomisert til everolimus versus de som ble randomisert til placebo. Samlet overlevelse er definert som tiden fra registreringsdatoen til dødsdatoen på grunn av en hvilken som helst årsak, eller pasienter som sist var kjent for å være i live blir sensurert på deres siste kontaktdato.	5 år fra registrering
Hyppighet og alvorlighetsgrad av toksisiteter Tidsramme: Inntil 54 ukers behandling	Antall deltakere med grad 3-5 bivirkninger som muligens, sannsynligvis eller definitivt er relatert til studiemedikamentet, er rapportert. Målt med CTCAE v4.0.	Inntil 54 ukers behandling

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

SWOG Cancer Research Network

Samarbeidspartnere

National Cancer Institute (NCI)

Etterforskere

Hovedetterforsker: Christopher W. Ryan, MD, OHSU Knight Cancer Institute

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Generelle publikasjoner

Hjelpsomme linker

Related Info

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

1. april 2011

Primær fullføring (Faktiske)

1. juli 2023

Studiet fullført (Faktiske)

1. september 2025

Datoer for studieregistrering

Først innsendt

7. mai 2010

Først innsendt som oppfylte QC-kriteriene

7. mai 2010

Først lagt ut (Antatt)

10. mai 2010

Oppdateringer av studieposter

Sist oppdatering lagt ut (Antatt)

16. september 2025

Siste oppdatering sendt inn som oppfylte QC-kriteriene

15. september 2025

Sist bekreftet

1. september 2025

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

S0931 (Annen identifikator: SWOG)
U10CA032102 (U.S. NIH-stipend/kontrakt)
NCI-2011-02028 (Annen identifikator: NCI)

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

Studiedata/dokumenter

Datasett for individuell deltaker
Informasjonskommentarer: Data tilgjengelig: Velg individuelle pasientnivådata fra denne studien kan bes om fra NCTN/NCORP Data Archive.

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

S0931, Everolimus i behandling av pasienter med nyrekreft som har gjennomgått kirurgi (S0931)

EVEREST: EVERolimus for nyrekreft som følge av kirurgisk terapi, en fase III-studie

Studieoversikt

Status

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

Studietype

Registrering (Faktiske)

Fase

Kontakter og plasseringer

Studiesteder

Deltakelseskriterier

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

Tar imot friske frivillige

Beskrivelse

Studieplan

Hvordan er studiet utformet?

Designdetaljer

Antall våpen

Våpen og intervensjoner

Deltakergruppe / Arm

Intervensjon / Behandling

Hva måler studien?

Primære resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Samarbeidspartnere og etterforskere

Sponsor

Samarbeidspartnere

Etterforskere

Publikasjoner og nyttige lenker

Generelle publikasjoner

Hjelpsomme linker

Studierekorddatoer

Studer hoveddatoer

Studiestart (Faktiske)

Primær fullføring (Faktiske)

Studiet fullført (Faktiske)

Datoer for studieregistrering

Først innsendt

Først innsendt som oppfylte QC-kriteriene

Først lagt ut (Antatt)

Oppdateringer av studieposter

Sist oppdatering lagt ut (Antatt)

Siste oppdatering sendt inn som oppfylte QC-kriteriene

Sist bekreftet

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

Studiedata/dokumenter