- ICH GCP
- US Clinical Trials Registry
- Klinisk utprøving NCT07755618
Characterization of Doxycycline Pharmacokinetics and Adherence
Characterization of Doxycycline Pharmacokinetics and Adherence Post-Single and Repeat Dosing Schemas
Studieoversikt
Status
Forhold
Detaljert beskrivelse
Studietype
Registrering (Antatt)
Fase
- Fase 1
Kontakter og plasseringer
Studiesteder
-
-
North Carolina
-
Chapel Hill, North Carolina, Forente stater, 27599
- University of North Carolina at Chapel Hill
-
-
Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
- Voksen
- Eldre voksen
Tar imot friske frivillige
Beskrivelse
Inclusion Criteria:
- Aged 18 to 65 years of age at the time of screening
- Able and willing to follow study participation requirements and provide informed consent to take part in the study
- Has a non-reactive/negative HIV test results at screening per applicable algorithm
- Has and is able to maintain a caput (head) of hair, that has not been chemically treated (defined as hair that has been bleached, permed, relaxed or dyed/colored) and is greater than one centimeter in length for the duration of the study
- For females of reproductive potential: Has a negative urine pregnancy test at screening
For females of reproductive potential: Using at least two effective methods of contraception for at least 30 days (inclusive) prior to enrollment and intending to use two effective methods of contraception for the duration of study participation. It is strongly recommended that at least one barrier method (e.g. condoms) in addition to a hormonal contraception method be used. Examples of acceptable and effective methods include:
- Hormonal methods (oral pills, vaginal ring, depo, transdermal or implant)
- Intrauterine device (IUD) inserted at least 30 days prior to enrollment
- Surgical sterilization (of participant or partner(s)) including bilateral tubal ligation or vasectomized male partners
- Barrier methods (condom with/without spermicide, sponge, cervical cap, diaphragm)
- Self-identifies as having same sex partners
- Self-reported sexually abstinent as defined by abstaining from penile-vaginal intercourse for 90 days prior to enrollment and intending to remain sexually abstinent for the duration of study participation
- Has access to a smartphone and/or laptop and is able and willing to participate in video-based communications with study staff for directly observed dosing requirements
- In good general health, in the opinion of the investigator of record (IoR) or designee and has no medical condition that would adversely impact the conduct of the study (inclusive of self-reported conditions and/or those found upon medical history and examination or in available medical records). This includes, but is not limited to, having an intact, healthy gastrointestinal tract (without damage or functional disruption) and the ability to swallow pills
Exclusion Criteria:
- Per participant report, planned or active use of any anticonvulsants at screening and an unwillingness to restrict use of certain medications (iron, antacids, etc.) for the duration of the study
- For females of reproductive potential: Pregnant or currently breastfeeding, or intends to become pregnant and/or breastfeed during the study
Has any of the following laboratory abnormalities:
- An estimated calculated creatinine clearance (CrCl) less than 60 mL/min by the Cockcroft-Gault formula at screening
- Positive for hepatitis B surface antigen (HBsAg) at screening
- Has a Grade 2 or higher clinically significant laboratory abnormality as defined by The Division of AIDS Table for Grading the Severity of Adult and Pediatric Adverse Events, Corrected Version 2.1 - July 2017 (exception: a CrCl ≥ 60 mL/min at enrollment is permissible for enrollment)
- Per participant reported symptoms or clinical and/or laboratory diagnosis of an active pharyngeal, anorectal, or reproductive tract infection (RTI) requiring treatment at screening and enrollment per current US Centers for Disease Control and Prevention (CDC) guidelines (https://www.cdc.gov/std/treatment-guidelines/default.htm). Infections requiring treatment include Neisseria gonorrhoeae (GC), Chlamydia trachomatis (CT), syphilis, active herpes simplex virus (HSV) lesions, or symptomatic genital warts, chancroid, pelvic inflammatory disease (PID), bacterial vaginosis (BV), symptomatic vaginal candidiasis, and trichomoniasis
- Participation in research studies involving drugs, products, or vaccines within 30 days of the enrollment and for the duration of the study
- Has donated blood within 8 weeks of enrollment of approximately 1 pint (550 mL)
- Has a known allergy (adverse reaction) to any of the components of the study product, including known hypersensitivity to tetracycline-class antibiotics
- Prior use of doxycycline or any other tetracycline-class antibiotic within 30 days prior to enrollment
- Has an active infection that may be responsive to treatment with doxycycline or another tetracycline antibiotic
- Has evidence or history of any other condition (e.g., gastrectomy, seizure disorder), that, in the opinion of the IoR or designee, would make study participation unsafe, complicate interpretation of study outcome data, or otherwise interfere with achieving study objectives
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Grunnvitenskap
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Eksperimentell: Single-Dose PK Phase- 200mg delayed release (DR) doxycycline tablet
Participants in this arm will take one 200 mg delayed release (DR) doxycycline hyclate tablet
|
One 200 mg doxycycline hyclate delayed release (DR) tablet
|
|
Eksperimentell: Multi-Dose PK Phase- daily dosing (every 24 hours)
Participants randomized to this arm will receive one 200mg doxycycline hyclate delayed release (DR) tablet daily (every 24 hours) for 10 days.
|
One 200 mg doxycycline hyclate delayed release (DR) tablet every 24 hours
|
|
Eksperimentell: Single Dose PK Phase- Two 100mg immediate release (IR) doxycycline tablets
Participants in this arm will take two 100mg immediate release (IR) doxycycline hyclate tablets
|
Two 100 mg doxycycline hyclate immediate-release (IR) tablets
|
|
Eksperimentell: Multi-dose PK Phase- Intermittent (every 72 hours) dosing
Participants randomized to this arm will receive one 200mg doxycycline hyclate delayed release (DR) tablet intermittently (every 72 hours) for 10 days.
|
One 200 mg doxycycline hyclate delayed release (DR) tablet every 72 hours
|
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Maximum observed plasma concentration (Cmax) for 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) plasma doxycycline hyclate Cmax (ng/mL units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Minimum observed plasma concentration (Cmin) for 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) plasma doxycycline hyclate Cmin (ng/mL units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Time to reach maximum plasma concentration (Tmax) of 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) plasma doxycycline hyclate Tmax (hours units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Plasma half-life (T1/2) of 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) plasma doxycycline hyclate half-life (T1/2, hours units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Area Under the Concentration-Time Curve in plasma From One to 336 Hours After Dosing (AUC0-24) of 200mg doxycycline hyclate.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) plasma doxycycline hyclate area under the concentration time curve (AUC)0-inf (ng*hr/mL units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Plasma concentrations at 24 hours (C24) post last dose of doxycycline following 10 days of daily or intermittent dosing.
Tidsramme: 24 hours post last dose of the multiple dose phase.
|
Median (IQR) plasma concentration at 24 hours post last dose (ng/mL units)
|
24 hours post last dose of the multiple dose phase.
|
|
Plasma concentrations at 48 hours (C48) post last dose of doxycycline following 10 days of daily or intermittent dosing.
Tidsramme: 48 hours post last dose of the multiple dose phase.
|
Median (IQR) plasma concentration at 48 hours post last dose (ng/mL units)
|
48 hours post last dose of the multiple dose phase.
|
|
Plasma concentrations at 72 hours (C72) post last dose of doxycycline following 10 days of daily or intermittent dosing.
Tidsramme: 72 hours post last doseof the multiple dose phase.
|
Median (IQR) plasma concentration at 72 hours post last dose (ng/mL units)
|
72 hours post last doseof the multiple dose phase.
|
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Number of gastrointestinal (GI)-related adverse events reported after doxycycline hyclate dosing during the multiple dose phase.
Tidsramme: Study visit days 14-23
|
Number of GI-related adverse events during 10 days of daily or intermittent doxycycline dosing
|
Study visit days 14-23
|
|
Number of gastrointestinal (GI)-related adverse events reported after doxycycline hyclate dosing after the multiple dose phase.
Tidsramme: Up to 14 days post last dose.
|
Number of GI-related adverse events for 14 days following final daily or intermittent dose (through the Final/Day 37 visit)
|
Up to 14 days post last dose.
|
|
Maximum observed dried blood spot (DBS) concentration (Cmax) for 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) DBS doxycycline hyclate Cmax (ng/mL units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Minimum observed dried blood spot (DBS) concentration (Cmin) for 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) DBS doxycycline hyclate Cmin (ng/mL units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Time to reach maximum dried blood spot (DBS) concentration (Tmax) of 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) DBS doxycycline hyclate Tmax (hours units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Dried blood spot (DBS) half-life (T1/2) of 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) DBS doxycycline hyclate half-life (T1/2, hours units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Area Under the Concentration-Time Curve in dried blood spots (DBS) From One to 336 Hours After Dosing (AUC0-24) of 200mg doxycycline hyclate.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) DBS doxycycline hyclate area under the concentration time curve (AUC)0-inf (ng*hr/mL units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Maximum observed anorectal fluid concentration (Cmax) for 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) anorectal doxycycline hyclate Cmax (ng/swab units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Minimum observed anorectal fluid concentration (Cmin) for 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) anorectal doxycycline hyclate Cmin (ng/swab units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Time to reach maximum anorectal fluid concentration (Tmax) of 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) anorectal doxycycline hyclate Tmax (hours units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Anorectal fluid half-life (T1/2) of 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) anorectal doxycycline hyclate half-life (T1/2, hours units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Area Under the Concentration-Time Curve in anorectal fluid From One to 336 Hours After Dosing (AUC0-24) of 200mg doxycycline hyclate.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) anorectal doxycycline hyclate area under the concentration time curve (AUC)0-inf (ng*hr/swab units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Maximum observed vaginal fluid concentration (Cmax) for 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) vaginal doxycycline hyclate Cmax (ng/swab units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Minimum observed vaginal fluid concentration (Cmin) for 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) vaginal doxycycline hyclate Cmin (ng/swab units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Time to reach maximum vaginal fluid concentration (Tmax) of 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) vaginal doxycycline hyclate Tmax (hours units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Vaginal fluid half-life (T1/2) of 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) vaginal doxycycline hyclate half-life (T1/2, hours units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Area Under the Concentration-Time Curve in vaginal fluid From One to 336 Hours After Dosing (AUC0-24) of 200mg doxycycline hyclate.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Median (IQR) vaginal doxycycline hyclate area under the concentration time curve (AUC)0-inf (ng*hr/swab units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Maximum observed pooled urine concentration (Cmax) for 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Mean (95% CI) urine doxycycline hyclate Cmax (ng/mL units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Minimum observed pooled urine concentration (Cmin) for 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Mean (95% CI) urine doxycycline hyclate Cmin (ng/mL units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Time to reach maximum pooled urine concentration (Tmax) of 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Mean (95% CI) urine doxycycline hyclate Tmax (hours units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Pooled urine half-life (T1/2) of 200mg doxycycline hyclate after a single dose.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Mean (95% CI) urine doxycycline hyclate half-life (T1/2, hours units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Area Under the Concentration-Time Curve in urine From One to 336 Hours After Dosing (AUC0-24) of 200mg doxycycline hyclate.
Tidsramme: 1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
Mean (95% CI) urine doxycycline hyclate area under the concentration time curve (AUC)0-inf (ng*hr/mL units)
|
1, 2, 3, 4, 6, 8, 24, 72, 96, 168, 240, and 336 hours post dose.
|
|
Dried blood spot (DBS) concentrations at 24 hours (C24) post last dose of doxycycline following 10 days of daily or intermittent dosing.
Tidsramme: 24 hours post last dose of the multiple dose phase.
|
Median (IQR) DBS concentration at 24 hours post last dose (ng/mL units)
|
24 hours post last dose of the multiple dose phase.
|
|
Dried blood spot (DBS) concentrations at 48 hours (C48) post last dose of doxycycline following 10 days of daily or intermittent dosing.
Tidsramme: 48 hours post last dose of the multiple dose phase.
|
Median (IQR) DBS concentration at 48 hours post last dose (ng/mL units)
|
48 hours post last dose of the multiple dose phase.
|
|
Dried blood spot (DBS) concentrations at 72 hours (C72) post last dose of doxycycline following 10 days of daily or intermittent dosing.
Tidsramme: 72 hours post last dose of the multiple dose phase.
|
Median (IQR) DBS concentration at 72 hours post last dose (ng/mL units)
|
72 hours post last dose of the multiple dose phase.
|
|
Urine concentrations at 24 hours (C24) post last dose of doxycycline following 10 days of daily or intermittent dosing.
Tidsramme: 24 hours post last dose of the multiple dose phase.
|
Median (IQR) urine concentration at 24 hours post last dose (ng/mL units)
|
24 hours post last dose of the multiple dose phase.
|
|
Urine concentrations at 48 hours (C48) post last dose of doxycycline following 10 days of daily or intermittent dosing.
Tidsramme: 48 hours post last dose of the multiple dose phase.
|
Median (IQR) urine concentration at 48 hours post last dose (ng/mL units)
|
48 hours post last dose of the multiple dose phase.
|
|
Urine concentrations at 72 hours (C72) post last dose of doxycycline following 10 days of daily or intermittent dosing.
Tidsramme: 72 hours post last dose of the multiple dose phase.
|
Median (IQR) urine concentration at 72 hours post last dose (ng/mL units)
|
72 hours post last dose of the multiple dose phase.
|
|
Anorectal fluid concentrations at 24 hours (C24) post last dose of doxycycline following 10 days of daily or intermittent dosing.
Tidsramme: 24 hours post last dose of the multiple dose phase.
|
Median (IQR) anorectal concentration at 24 hours post last dose (ng/swab units)
|
24 hours post last dose of the multiple dose phase.
|
|
Anorectal fluid concentrations at 48 hours (C48) post last dose of doxycycline following 10 days of daily or intermittent dosing.
Tidsramme: 48 hours post last dose of the multiple dose phase.
|
Median (IQR) anorectal concentration at 48 hours post last dose (ng/swab units)
|
48 hours post last dose of the multiple dose phase.
|
|
Anorectal fluid concentrations at 72 hours (C72) post last dose of doxycycline following 10 days of daily or intermittent dosing.
Tidsramme: 72 hours post last dose of the multiple dose phase.
|
Median (IQR) anorectal concentration at 72 hours post last dose (ng/swab units)
|
72 hours post last dose of the multiple dose phase.
|
|
Vaginal fluid concentrations at 24 hours (C24) post last dose of doxycycline following 10 days of daily or intermittent dosing.
Tidsramme: 24 hours post last dose of the multiple dose phase.
|
Median (IQR) vaginal concentration at 24 hours post last dose (ng/swab units)
|
24 hours post last dose of the multiple dose phase.
|
|
Vaginal fluid concentrations at 48 hours (C48) post last dose of doxycycline following 10 days of daily or intermittent dosing.
Tidsramme: 48 hours post last dose of the multiple dose phase.
|
Median (IQR) vaginal concentration at 48 hours post last dose (ng/swab units)
|
48 hours post last dose of the multiple dose phase.
|
|
Vaginal fluid concentrations at 72 hours (C72) post last dose of doxycycline following 10 days of daily or intermittent dosing.
Tidsramme: 72 hours post last dose of the multiple dose phase.
|
Median (IQR) vaginal concentration at 72 hours post last dose (ng/swab units)
|
72 hours post last dose of the multiple dose phase.
|
Samarbeidspartnere og etterforskere
Sponsor
Samarbeidspartnere
Etterforskere
- Studiestol: Mackenzie Cottrell, PharmD, MS, University of North Carolina, Chapel Hill
- Studiestol: Mark Marzinke, PhD, Johns Hopkins University
Studierekorddatoer
Studer hoveddatoer
Studiestart (Faktiske)
Primær fullføring (Antatt)
Studiet fullført (Antatt)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Faktiske)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- HPTN 117
- UM1AI068619 (U.S. NIH-stipend/kontrakt)
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
IPD-planbeskrivelse
IPD-delingstidsramme
Tilgangskriterier for IPD-deling
IPD-deling Støtteinformasjonstype
- STUDY_PROTOCOL
- SEVJE
Legemiddel- og utstyrsinformasjon, studiedokumenter
Studerer et amerikansk FDA-regulert medikamentprodukt
Studerer et amerikansk FDA-regulert enhetsprodukt
produkt produsert i og eksportert fra USA
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