- ICH GCP
- Amerikanska kliniska prövningsregistret
- Klinisk prövning NCT01017640
Veliparib With or Without Mitomycin C in Treating Patients With Metastatic, Unresectable, or Recurrent Solid Tumors
ABT-888 as Monotherapy and in Combination With Mitomycin C in Patients With Solid Tumors With Deficiency in Homologous Recombination Repair
Studieöversikt
Status
Betingelser
Intervention / Behandling
Detaljerad beskrivning
PRIMARY OBJECTIVES:
I. To screen cancer patients across different histological sites to identify those with functional defects in the Fanconi anemia (FA) pathway in their tumors.
II. To establish the safety and practicality of treating patients with FA deficient tumors with the poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitor ABT-888 (veliparib) as protracted monotherapy.
III. To establish the safety and practicality of treating patients with FA deficient tumors with the combination of mitomycin C (MMC) and ABT-888.
IV. To select a dose of ABT-888 protracted monotherapy and a dose-schedule of the combination of mitomycin C and ABT-888 in patients with FA deficient tumors for phase 2 trials.
SECONDARY OBJECTIVES:
I. To evaluate for germ-line FA repair deficiency and BRCA mutations in peripheral blood mononuclear (PBMC) in patients receiving ABT-888 treatment.
II. To evaluate in PBMC samples for foci produced by the histone variant gamma-H2A histone family, member X (H2AX) in patients receiving mitomycin C with or without ABT-888 in order to assess any possible effect of ABT-888 in the cellular sensing and processing of mitomycin C-induced deoxyribonucleic acid (DNA) double strand breaks.
III. Quantify the number of patients with antitumor responses.
OUTLINE: This is a dose-escalation study of veliparib. Patients are assigned to 1 of 2 treatment arms.
ARM I: Patients receive veliparib orally (PO) twice daily (BID) in the absence of disease progression or unacceptable toxicity.
ARM II: Patients receive veliparib PO BID on days 1-7, 1-14, or 1-21. Patients also receive mitomycin C intravenously (IV) over 10-20 minutes on day 1. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up for 12 weeks.
Studietyp
Inskrivning (Faktisk)
Fas
- Fas 1
Kontakter och platser
Studieorter
-
-
Kentucky
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Georgetown, Kentucky, Förenta staterna, 40324
- Georgetown Cancer Treatment Center
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-
Ohio
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Columbus, Ohio, Förenta staterna, 43210
- Ohio State University Comprehensive Cancer Center
-
-
Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
Tar emot friska volontärer
Kön som är behöriga för studier
Beskrivning
Inclusion Criteria:
- Patients must have a histologically confirmed solid malignancy that is metastatic, or unresectable, or recurrent, for which no curative or standard of care exist, or this standard of care is no longer effective
- Tumors have been shown to be deficient for the FA pathway, based on Fanconi anemia triple stain immunofluorescence (FATSI) screening
- Patients will be consented to have their existing, or about to be obtained, paraffin embedded tumor tissue screened for FA deficiency; screening will be performed on an ongoing basis on the breast, thoracic, gastrointestinal (GI), Georgetown University (GU), and gynecologic (GYN) Ohio State University (OSU) clinics, anteceding and concurrently with the clinical trial; it will continue until the numbers of patients required for the clinical trial are identified and enrolled; based on the estimation from our preliminary data of 15 to 30% of patients, depending on the primary organ site, having tumors deficient for the FA pathway we will need to screen around 300 patients' samples to identify 40-50 patients; none of the eligibility criteria defined above or below will need to be met for the screening portion, since FA deficient patients identified by screening may meet eligibility criteria for the clinical trial at a later time; (e.g., patient is undergoing standard of care treatment at the time of the screening); separate written consents for screening and for the clinical trial will be obtained from patients
- Up to two chemotherapy regimens for metastatic disease are allowed; in addition, prior adjuvant/neo-adjuvant chemotherapy, hormonal therapy, molecular targeted therapy or estrogen receptor B (Erb) inhibitor treatments (e.g., erlotinib, Herceptin, sorafenib, sunitinib) will be allowed and will not count towards eligibility; at least 4 weeks must elapse since prior chemotherapy or radiation therapy (two weeks for erlotinib, hormonal therapy, or limited field palliative radiation to bone, brain, or radiosurgery), 6 weeks if the last regimen included nitrosoureas or mitomycin C; previous use of mitomycin C would be restricted to topical applications (bladder cancer) or chemoembolization (e.g., liver tumors)
- Eastern Cooperative Oncology Group (ECOG) performance status =< 2 (Karnofsky >= 60%)
- Life expectancy of greater than 3 months
- Leukocytes >= 3,000/mcL
- Absolute neutrophil count (ANC) >= 1,500/mcL
- Hemoglobin >= 9 g/dL
- Platelets >= 100,000/mcL
- Total bilirubin within normal institutional limit
- Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional upper limit of normal
- Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal
- Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation; should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately
- Ability to understand and the willingness to sign a written informed consent document
- Patients should be able to swallow capsules
EXPANSION COHORT:
- Diagnosis of colorectal malignancy
- Absence of Fanconi anemia, complementation group D2 (FANCD2) foci by FATSI screening
- Presence of biopsiable lesion by imaging
- Consent to a baseline (prior to treatment) tumor biopsy and for a repeat biopsy at the time of progression on the event that an antitumor response is demonstrated on the MMC-ABT-888 regimen
- Same eligibility as above, except that they will have no limitations related prior number of chemotherapy regimens given; patients could have received prior treatment with PARP inhibitors if used as single agent
Exclusion Criteria:
- Patients may not be receiving any other investigational agents
- Patients with known central nervous system (CNS) metastases (unless previously resected or irradiated and not clinically active); patients with CNS metastases must be stable after therapy for > 3 months and off steroid treatment prior to study enrollment
- History of allergic reactions attributed to compounds of similar chemical or biologic composition as ABT-888 or Mitomycin C
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- Pregnant women are excluded from this study; breastfeeding should be discontinued
- Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
- Patients with active seizure or a history of seizures
- Patients previously treated with PARP inhibitors; with the exception of patients enrolled on Arm 2 who may have had prior treatment with PARP inhibitors as monotherapy
Studieplan
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Behandling
- Tilldelning: Icke-randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Ingen (Open Label)
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
---|---|
Experimentell: Arm I (veliparib)
Patients receive veliparib PO BID in the absence of disease progression or unacceptable toxicity.
|
Korrelativa studier
Givet PO
Andra namn:
|
Experimentell: Arm II (veliparib and mitomycin C)
Patients receive veliparib PO BID on days 1-7, 1-14, or 1-21.
Patients also receive mitomycin C IV over 10-20 minutes on day 1.
Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
|
Korrelativa studier
Givet PO
Andra namn:
Givet IV
Andra namn:
|
Vad mäter studien?
Primära resultatmått
Resultatmått |
Tidsram |
---|---|
Ability to safely deliver the combination of mitomycin C and veliparib
Tidsram: Up to 12 weeks post-treatment
|
Up to 12 weeks post-treatment
|
Ability to safely deliver veliparib in a continuous dose as monotherapy
Tidsram: Up to 12 weeks post-treatment
|
Up to 12 weeks post-treatment
|
Feasibility of screening for FA deficiency across different tumor types, defined as adequate number of patients deficient on this pathway
Tidsram: Up to 12 weeks post-treatment
|
Up to 12 weeks post-treatment
|
Selection of a dose schedule of the combination of mitomycin C and veliparib for phase II trials
Tidsram: Up to 12 weeks post-treatment
|
Up to 12 weeks post-treatment
|
Selection of a dose schedule of veliparib monotherapy for phase II trials
Tidsram: Up to 12 weeks post-treatment
|
Up to 12 weeks post-treatment
|
Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
---|---|---|
BRCA mutations
Tidsram: Baseline
|
Descriptive statistics will be provided: proportions for categorical variables; mean and standard deviation for the continuous variables.
|
Baseline
|
FancD2 foci formation in peripheral blood mononuclear cells
Tidsram: Up to week 5
|
Descriptive statistics will be provided: proportions for categorical variables; mean and standard deviation for the continuous variables.
|
Up to week 5
|
Foci produced by the histone variant gamma-H2AX
Tidsram: Up to week 5
|
Descriptive statistics will be provided: proportions for categorical variables; mean and standard deviation for the continuous variables.
|
Up to week 5
|
Tumor shrinkage as assessed by radiological means
Tidsram: Up to 12 weeks post-treatment
|
Up to 12 weeks post-treatment
|
Samarbetspartners och utredare
Sponsor
Utredare
- Huvudutredare: Sameh Mikhail, Ohio State University Comprehensive Cancer Center
Studieavstämningsdatum
Studera stora datum
Studiestart
Primärt slutförande (Faktisk)
Studieregistreringsdatum
Först inskickad
Först inskickad som uppfyllde QC-kriterierna
Första postat (Uppskatta)
Uppdateringar av studier
Senaste uppdatering publicerad (Uppskatta)
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
Senast verifierad
Mer information
Termer relaterade till denna studie
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- NCI-2012-01473 (Registeridentifierare: CTRP (Clinical Trial Reporting Program))
- P30CA016058 (U.S.S. NIH-anslag/kontrakt)
- N01CM62207 (U.S.S. NIH-anslag/kontrakt)
- N01CM00070 (U.S.S. NIH-anslag/kontrakt)
- OSU-09100
- OSU# 09100
- 2009C0069
- 09100
- NCI 8472
- CDR0000656393
- OSU 09100 (Annan identifierare: Ohio State University Comprehensive Cancer Center)
- 8472 (Annan identifierare: CTEP)
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