Effects of Acute Exercise on Various Parameters in Individuals With Alcohol Use Disorders
Effects of Acute Exercise on Psychological, Physiological, Biochemical and Alcohol-related Parameters in Individuals With Alcohol Use Disorders
研究概览
地位
详细说明
The mechanism of incentives that lead people to unhealthy habits such as excessive alcohol consumption is not only social, personal, and psychological, but also associated with neurochemical and neurobiological mechanisms.
Several programs have been developed to stop excessive drinking, but the success rates are small, while the relapse rates are very high, reaching up to 90%. Although there is some evidence for the beneficial effects of exercise on alcohol use disorders (AUDs), research is limited. The present study investigates whether exercise could be a safe adjunct therapy for alcohol abuse cessation, and the possible mechanisms involved.
One of the basic assumptions is that the appropriate form of exercise in individuals with AUDs will contribute to the secretion of beta-endorphin, which in combination with psychological pleasure, vitality, change of mood, reduced stress, increased confidence, and the shift of attention will help people to follow healthy lifestyles and abhor alcohol.
The research project is divided in three phases. In the first phase, (current study) the effect of acute exercise in critical psychological, physiological, biochemical and alcohol-related parameters associated with excessive alcohol consumption will be examined. In the second phase, a long-term exercise program in conjunction with psychological support strategies aimed at alcohol abuse cessation will be developed, implemented and evaluated. Finally, in the third phase, based on the results of the previous phases, awareness programs in adolescent and adult populations will be designed and implemented as well as the dissemination of results and evaluation of the project will take place.
研究类型
注册 (实际的)
阶段
- 不适用
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
For alcoholics:
Inclusion Criteria:
- Confirmed alcohol addiction according to Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria in the past, after detoxification phase, lack of dependence on other substances
- Alcohol Use Disorders Identification Test (AUDIT) score>20
Exclusion Criteria:
- Medical conditions or medication use that would preclude participation in aerobic exercise
For heavy drinkers:
Inclusion Criteria:
- Men drinking >14 drinks/week or >4 drinks/occasion; Women drinking >7 drinks/week or >4 drinks/occasion (1 drink = 14 grams of pure alcohol; definition of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) for drinking at low risk for developing an AUD; NIAAA, 2014)
- Individuals drinking 5 or more drinks on the same occasion on each of 5 or more days in the past 30 days (1 drink = 14 grams of pure alcohol; definition of the Substance Abuse and Mental Health Services Administration for heavy drinking; NIAAA, 2014)
- AUDIT score>8
Exclusion Criteria:
- Medical conditions or medication use that would preclude participation in aerobic exercise
For healthy controls:
Inclusion Criteria:
- Men drinking <14 drinks/week or <4 drinks/occasion; Women drinking <7 drinks/week or <4 drinks/occasion (1 drink = 14 grams of pure alcohol; definition of the NIAAA for drinking at low risk for developing an AUD; NIAAA, 2014)
- Individuals drinking <5 drinks on the same occasion on each of 5 or more days in the past 30 days (1 drink = 14 grams of pure alcohol; definition of the Substance Abuse and Mental Health Services Administration for heavy drinking; NIAAA, 2014)
- AUDIT score<8
Exclusion Criteria:
- Medical conditions or medication use that would preclude participation in aerobic exercise
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：非随机化
- 介入模型：并行分配
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：Heavy drinkers
The effects of acute exercise in heavy drinkers.
Participants will cycle on ergometer for 30 min at 50-60% of Heart Rate Reserve (HRR).
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A group of heavy drinkers and a group of healthy controls (individuals without alcohol use disorders) will cycle on a cycle ergometer for 30 min at 50-60% of HRR.
Before and immediately after exercise blood will be drawn and psychological and physiological parameters will be measured.
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实验性的：Alcoholic patients
The effects of acute exercise in alcoholic patients.
Participants will cycle on ergometer for 30 min at 55-60% of Heart Rate maximal (HRmax).
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A group of alcoholic patients (10-14 days after detoxification) and a group of healthy controls (individuals without alcohol use disorders) will cycle on a cycle ergometer for 30 min at 55-60% of HRmax.
Before and immediately after exercise blood will be drawn and psychological and physiological parameters will be measured.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Changes in Urge to drink score
大体时间：Before (0 min) and after exercise trial (30 min)
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According to questionnaire
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Before (0 min) and after exercise trial (30 min)
|
|
Changes in Beta-endorphin levels
大体时间：Before (0 min) and after exercise trial (30 min)
|
Measured by radioimmunoassay (RIA)
|
Before (0 min) and after exercise trial (30 min)
|
|
Changes in Cortisol levels
大体时间：Before (0 min) and after exercise trial (30 min)
|
Measured by radioimmunoassay (RIA)
|
Before (0 min) and after exercise trial (30 min)
|
|
Changes in Adrenocorticotrophic hormone (ACTH) levels
大体时间：Before (0 min) and after exercise trial (30 min)
|
Measured by radioimmunoassay (RIA)
|
Before (0 min) and after exercise trial (30 min)
|
|
Changes in Catecholamines (epinephrine, norepinephrine, dopamine) levels
大体时间：Before (0 min) and after exercise trial (30 min)
|
Measured by radioimmunoassay (RIA)
|
Before (0 min) and after exercise trial (30 min)
|
|
Changes in C-reactive protein (CRP) levels
大体时间：Before (0 min) and after exercise trial (30 min)
|
Semi-quantitative estimation with CRP Latex test kit
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Before (0 min) and after exercise trial (30 min)
|
|
Changes in Complete blood count values
大体时间：Before (0 min) and after exercise trial (30 min)
|
Autoanalyzer
|
Before (0 min) and after exercise trial (30 min)
|
|
Changes in Lactic acid levels
大体时间：Before (0 min) and after exercise trial (30 min)
|
Measured using photometry
|
Before (0 min) and after exercise trial (30 min)
|
|
Changes in Erythrocyte sedimentation rate (ESR) values
大体时间：Before (0 min) and after exercise trial (30 min)
|
Wintrobe Method
|
Before (0 min) and after exercise trial (30 min)
|
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Changes in γ-Glutamyltransferase (GGT) levels
大体时间：Before (0 min) and after exercise trial (30 min)
|
Measured with commercial kit
|
Before (0 min) and after exercise trial (30 min)
|
|
Changes in Aspartate Aminotransferase (AST) levels
大体时间：Before (0 min) and after exercise trial (30 min)
|
Measured with commercial kit
|
Before (0 min) and after exercise trial (30 min)
|
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Changes in Alanine Aminotransferase (ALT) levels
大体时间：Before (0 min) and after exercise trial (30 min)
|
Measured with commercial kit
|
Before (0 min) and after exercise trial (30 min)
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Sit and reach flexibility test for the hamstrings muscles and lower back
大体时间：Before trial (baseline)
|
Each participant sits on the floor with legs stretched out straight ahead, reaches out and holds that position for at 1-2 seconds while the distance is recorded.
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Before trial (baseline)
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Grip strength
大体时间：Before trial (baseline)
|
Handgrip strength test
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Before trial (baseline)
|
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Number of push-ups performed in one minute
大体时间：Before trial (baseline)
|
Before trial (baseline)
|
|
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Number of sit-ups performed until exhaustion
大体时间：Before trial (baseline)
|
Before trial (baseline)
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合作者和调查者
调查人员
- 学习椅：Yannis Theodorakis, PhD、University of Thessaly
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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