Study of Mechanisms of Emotion Regulation in Alcohol-abstinent Patients (REAL)
Study of Mechanisms of Emotion Regulation in Short- and Long-term Alcohol-abstinent Patients
Background:
Difficulties in assigning and identifying emotional states, or to regulate the emotional costs are recognized as one of the major factors of relapse. This study aimed to evaluate the emotion regulation processes, in short term (STA, after 1month of withdrawal) and long-term alcohol abstinent individuals (LTA, at least six months of abstinence), compared to healthy control participants (C) in a positive and negative emotion induction protocol.
Main aim:
Evaluating the emotional regulation deficits assessed with physiological indicators (heart rate variability, electrodermal response, pupil diameter) and clinically in presentations of visual stimuli to emotional value (positive, negative, neutral) in alcohol use disorder's (AUD) patients with short and long term abstinent compared to a control group of healthy subjects. The investigators are particularly interested in the evolution of heart rate variability considered as a good marker of vulnerability to AUD.
Secondary objectives:
Studying the relationships between physiological measures and clinical variables such as behavioral indicators and self-reported assessment of cognitive and emotional skills among the three groups (STA, LTA and C).
研究概览
详细说明
The recording was performed for all participants during presentation of high emotional inducing stimuli presenting human interactions (pictures and video sequences). For each participant physiological responses (pupil diameter, heart rate, and skin conductance) were recorded before, during and after induction.
Participants were asked to evaluate the intensity and the valence of emotional stimuli.
In addition, a neurological evaluation, a clinical and cognitive assessment were performed.
Neurological, clinical and cognitive evaluation - Each participant had a clinical structured interview, a neurological evaluation, self-administered assessment (Hospital Anxiety & Depression Scale, Emotional Skills Profile, Obsessive Compulsive Drinking Scale, and cognitive assessment (Montreal Cognitive Assessment).
Physiological assessment - The recording was performed for all participants during the presentation of pictures (static stimuli) or videos (dynamic stimuli) selected according to their high emotional intensity (positive, neutral and negative valence), representing human interactions. For each participant heart rate, electrodermal activity, and pupil diameter were recorded during three experimental conditions: rest, induction (presentation of stimuli) and after induction (recovery). Participants were asked to evaluate the intensity and valence of the pictures and videos using the Self-Assessment Manikin.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Lille、法国、59037
- CSAPA
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Lille、法国
- CHRU Lille, Fontan2
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
- Short term alcohol abstinent patients (STA, after 1month of withdrawal)
- Long-term alcohol abstinent individuals (at least six months of abstinence)
- Healthy control participants (C)
描述
Inclusion Criteria:
For STA and LTA groups :
- a diagnosis of severe alcohol use disorder (DSM5 criteria, 2013 confirmed by an addictonologist and a psychologist),
- successful completion of withdrawal,
- an intended treatment length of at least 1 month (for the STA group) or at least 6 months (for the LTA group).
For Control participants (C) :
- social drinkers, and were recruited from the general population (e.g. at the university).
Exclusion Criteria:
- with delusional psychiatric disorders (and/or medication for psychiatric disorders (excepted anxiolytics),
- neurological or cardiological disorders,
- taking medication that may act on heart rate or alter the regulation of body temperature or cognitive functions,
- with active co-dependence (except for tobacco)
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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控制组
健康受试者
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STA group
Short-term alcohol abstinent patients (after 1 month of withdrawal)
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LTA group
Long-term alcohol abstinent patients (at least 6 months of abstinence)
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Heart Rate Variability
大体时间：3 years
|
High measuring heart rate
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3 years
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Electrodermal response
大体时间：3 years
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skin conductance
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3 years
|
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pupil diameter
大体时间：3 years
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pupil diameter
|
3 years
|
|
HAD score
大体时间：3 years
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Score at the Hospital Anxiety & Depression Scale
|
3 years
|
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MocA assessment
大体时间：3 years
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Montréal cognitive Assessement score
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3 years
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合作者和调查者
调查人员
- 首席研究员：Olivier COTTENCIN, MD, PhD、University Hospital, Lille
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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