Does Oxytocin Modulate Rewarding Effects in Women and Fluctuating Across the Menstrual Cycle
Does Oxytocin Modulate Rewarding Effect of Metaphorical Compliments Fluctuating With Women's Fertility and Luteal Phase in a Romantic Context
研究概览
详细说明
To investigate whether oxytocin (24IU) might interact with female sex hormone in modulating the rewarding effect of compliment to women in a romantic context.
The study employs a double-blind, within-subject, placebo-control design. Women will be administered with the same drug twice (oxytocin or placebo) respectively the fertile and luteal phase followed by a MRI scanning. During fMRI participants will rate men's attraction based on their facial pictures of average attractiveness associated with compliments of different combination of form and topic. Each male face will be paired with two sentences of the same kind. After the fMRI participants will recall the judgment followed by a memory test during which they have to indicate whether the they have seen the face during scanning (old) or whether it is an unknown face (new).
研究类型
注册 (实际的)
阶段
- 第一阶段早期
联系人和位置
学习地点
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Sichuan
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Chengdu、Sichuan、中国、611731
- University of Electronic Science and Technology of Chia
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Single in the past 3 months
- Healthy subjects with regular menstrual cycle
Exclusion Criteria:
- Pregnant, menstruating, taking oral contraceptives
- metal implanted, with tatoo, or hair dyed within 6 months
- participated in another intranasal experiment within 6 months
- with a history of past or current psychiatric or neurological disorder
学习计划
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：双倍的
武器和干预
参与者组/臂 |
干预/治疗 |
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实验性的：oxytocin fertility
intranasal oxytocin administration (24IU) in women's fertility phase (LH>40 mIU/ml)
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其他名称：
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安慰剂比较：placebos fertility
intranasal placebo administration (24IU) in women's fertility phase (LH>40 mIU/ml)
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其他名称：
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实验性的：oxytocin luteal
intranasal oxytocin administration (24IU) in women's luteal phase (LH<30 mIU/ml)
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其他名称：
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安慰剂比较：placebos luteal
intranasal placebos administration (24IU) in women's luteal phase (LH<30 mIU/ml)
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其他名称：
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Oxytocin effect on neural activity as assessed via fMRI towards reward between fertility and luteal phases
大体时间：45min-120min after treatment
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Effects of oxytocin versus placebo nasal spray on neural processing of reward will be compared between different cycle phases
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45min-120min after treatment
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合作者和调查者
调查人员
- 首席研究员：Keith M Kendrick, Dr.、University of Electronic Science and Technology of China
出版物和有用的链接
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- UESTC-neuSCAN-22
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
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