TAS1R1, TAS1R3, TLR2, TLR4, CA6 Gene Polymorphism on Dental Caries
Variants in Taste Genes on Caries Risk and Caries Activity Status
研究概览
详细说明
To date, genes can be grouped into categories based on the factor influencing dental caries. The major candidate gene categories to date include enamel formation genes, immune response genes, genes related to saliva, and genes related to taste and dietary habits.
CA6 exists in the human saliva and has a critical role of buffering, immune response and taste.Toll-like receptors are expressed in the tongue gustatory papillae where they may initiate immune responses to pathogens.Genetic variations in the TAS1R1 and TAS1R3 for umami cause perception of these tastes differently.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Rize、火鸡、53000
- Recep Tayyip Erdogan University
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- adult be between 25 and 44 years old
- subject has DMFT (Decayed, Missing, Filled, Permanent Tooth) ≥ 5, or, DMFT ≥14
- same oral health, diet and socioeconomic status
Exclusion Criteria:
- systemic or genetic disorders
- orthodontic appliances
- pregnant women
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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high caries risk
100 adults will be allowed in the high caries risk group according to DMFT index (DMFT ≥ 14)
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DNAs were obtained from epithelial cells in buccal mucosa and were extracted with Genomic DNA Isolation Kit Genotyping for a variant was carried out on a Roche Applied Science LightCycler® 480 (Roche Diagnostics GmbH, Mannheim, Germany) with real-time polymerase reaction of Taqman
其他名称：
Dental caries lesions of all patient scored as initial, moderate or advanced caries Initial lesion; clinically detectable lesion Moderate; visible signs of enamel breakdown Advanced; enamel was fully cavitaed |
|
low caries risk
100 adults will be allowed in the low caries risk group according to DMFT index (DMFT ≤ 5)
|
DNAs were obtained from epithelial cells in buccal mucosa and were extracted with Genomic DNA Isolation Kit Genotyping for a variant was carried out on a Roche Applied Science LightCycler® 480 (Roche Diagnostics GmbH, Mannheim, Germany) with real-time polymerase reaction of Taqman
其他名称：
Dental caries lesions of all patient scored as initial, moderate or advanced caries Initial lesion; clinically detectable lesion Moderate; visible signs of enamel breakdown Advanced; enamel was fully cavitaed |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Past caries experience
大体时间：4 months
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Each tooth will be examined and recorded as decayed, missing, or filled (DMFT).
Caries will be defined in accordance with the World Health Organization (WHO 1997) criteria.
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4 months
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合作者和调查者
调查人员
- 首席研究员：Gül Yıldız Telatar, Dr.、Recep Tayyip Erdogan University Dentistry Faculty
出版物和有用的链接
一般刊物
- Yildiz G, Ermis RB, Calapoglu NS, Celik EU, Turel GY. Gene-environment Interactions in the Etiology of Dental Caries. J Dent Res. 2016 Jan;95(1):74-9. doi: 10.1177/0022034515605281. Epub 2015 Sep 16.
- Yildiz Telatar G, Saydam F, Guzel AI, Telatar BC. Variants in taste genes on caries risk and caries activity status. Med Mol Morphol. 2020 Dec;53(4):244-251. doi: 10.1007/s00795-020-00263-5. Epub 2020 Aug 7.
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- 2016/30
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
IPD 计划说明
药物和器械信息、研究文件
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