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T-DM1 和 Tucatinib 与单独使用 T-DM1 在预防高危 HER2 阳性乳腺癌患者复发方面的比较，CompassHER2 RD 试验

2026年6月11日更新者：Alliance for Clinical Trials in Oncology

CompassHER2 试验（综合使用病理反应评估优化 HER2 阳性乳腺癌的治疗）CompassHER2 残留病灶 (RD)，T-DM1 与 T-DM1 和 Tucatinib 相比的双盲 III 期随机试验

这项 III 期试验研究曲妥珠单抗 emtansine (T-DM1) 和图卡替尼在预防高危 HER2 阳性乳腺癌患者复发（复发）方面的作用。 T-DM1 是一种单克隆抗体，称为曲妥珠单抗，与一种称为 DM1 的化疗药物相连。曲妥珠单抗是一种靶向治疗，因为它附着在癌细胞表面的特定分子（受体）上，称为 HER2 受体，并递送 DM1 杀死它们。图卡替尼可以通过阻断细胞生长所需的一些酶来阻止肿瘤细胞的生长。与单独使用 T-DM1 相比，给予 T-DM1 和 tucatinib 可能更好地预防 HER2 阳性乳腺癌患者的乳腺癌复发。

研究概览

地位

主动，不招人

条件

干预/治疗

详细说明

主要目标：

I. 确定 T-DM1 和 tucatinib 的侵入性无病生存期 (iDFS) 是否优于对照组（T-DM1 + 安慰剂）中的 iDFS，当给予 HER2 阳性乳腺癌和残留的高风险患者时新辅助 HER2 靶向治疗后的疾病。

次要目标：

I. 评估与单独使用 T-DM1（T-DM1 加安慰剂）相比，图卡替尼加 T-DM1 治疗是否改善了以下方面：

我。无乳腺癌生存期 (BCFS)。 IB。远处无复发生存期 (DRFS)。我知道了。无脑转移生存期 (BMFS)。 ID。总生存期（OS）。二。评估与单独使用 T-DM1（T-DM1 加安慰剂）相比，图卡替尼加 T-DM1 治疗是否能降低脑转移的发生率。

大纲：患者被随机分配到 2 组中的 1 组。

ARM I：患者在第 1 天在 30-90 分钟内静脉内 (IV) 接受 T-DM1，在第 1-21 天每天两次 (BID) 口服安慰剂 (PO)。在没有疾病进展或不可接受的毒性的情况下，治疗每 21 天重复一次，最多 14 个周期。

ARM II：患者在第 1 天接受超过 30-90 分钟的 T-DM1 IV，并在第 1-21 天接受 tucatinib PO BID。在没有疾病进展或不可接受的毒性的情况下，治疗每 21 天重复一次，最多 14 个周期。

完成研究治疗后，患者在 30 天后接受随访，然后每 6 个月随访一次，持续 10 年。

研究类型

介入性

注册 (实际的)

1056

阶段

第三阶段

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

加拿大
- British Columbia
  - Vancouver、British Columbia、加拿大、V5Z 4E6
    - BCCA-Vancouver Cancer Centre
- New Brunswick
  - Saint John、New Brunswick、加拿大、E2L 4L2
    - Atlantic Health Sciences Corporation-Saint John Regional Hospital
- Ontario
  - London、Ontario、加拿大、N6A 4L6
    - London Regional Cancer Program
  - Oshawa、Ontario、加拿大、L1G 2B9
    - Lakeridge Health Oshawa
  - Toronto、Ontario、加拿大、M4N 3M5
    - Odette Cancer Centre- Sunnybrook Health Sciences Centre
  - Toronto、Ontario、加拿大、M5B 1W8
    - Saint Michael's Hospital
- Quebec
  - Québec、Quebec、加拿大、G1S 4L8
    - CHU de Quebec-Hopital du Saint-Sacrement (HSS)
- Saskatchewan
  - Regina、Saskatchewan、加拿大、S4T 7T1
    - Allan Blair Cancer Centre
  - Saskatoon、Saskatchewan、加拿大、S7N 4H4
    - Saskatoon Cancer Centre
波多黎各
- - Bayamón、波多黎各、00959-5060
    - Cancer Center-Metro Medical Center Bayamon
  - Bayamón、波多黎各、00961
    - Puerto Rico Hematology Oncology Group
  - Manati、波多黎各、00674
    - Doctors Cancer Center
  - San Juan、波多黎各、00917
    - San Juan Community Oncology Group
  - San Juan、波多黎各、00927
    - Centro Comprensivo de Cancer de UPR
  - San Juan、波多黎各、00936
    - San Juan City Hospital
  - San Juan、波多黎各、00927
    - PROncology
美国
- Alabama
  - Birmingham、Alabama、美国、35233
    - University of Alabama at Birmingham Cancer Center
  - Fairhope、Alabama、美国、36532
    - Thomas Hospital
  - Mobile、Alabama、美国、36607
    - Mobile Infirmary Medical Center
- Alaska
  - Anchorage、Alaska、美国、98508
    - Anchorage Associates in Radiation Medicine
  - Anchorage、Alaska、美国、99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage、Alaska、美国、99508
    - Alaska Oncology and Hematology LLC
  - Anchorage、Alaska、美国、99508
    - Alaska Women's Cancer Care
  - Anchorage、Alaska、美国、99508
    - Anchorage Oncology Centre
  - Anchorage、Alaska、美国、99508
    - Katmai Oncology Group
  - Anchorage、Alaska、美国、99508
    - Providence Alaska Medical Center
  - Anchorage、Alaska、美国、99504
    - Anchorage Radiation Therapy Center
  - Fairbanks、Alaska、美国、99701
    - Fairbanks Memorial Hospital
- Arizona
  - Gilbert、Arizona、美国、85234
    - Banner MD Anderson Cancer Center
  - Kingman、Arizona、美国、86401
    - Kingman Regional Medical Center
  - Phoenix、Arizona、美国、85004
    - Cancer Center at Saint Joseph's
  - Phoenix、Arizona、美国、85006
    - Banner-University Medical Center Phoenix
- Arkansas
  - Fort Smith、Arkansas、美国、72903
    - Mercy Hospital Fort Smith
  - Hot Springs、Arkansas、美国、71913
    - CHI Saint Vincent Cancer Center Hot Springs
  - Jonesboro、Arkansas、美国、72401
    - NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
  - Little Rock、Arkansas、美国、72205
    - University of Arkansas for Medical Sciences
- California
  - Arroyo Grande、California、美国、93420
    - PCR Oncology
  - Arroyo Grande、California、美国、93420
    - Mission Hope Medical Oncology - Arroyo Grande
  - Auburn、California、美国、95602
    - Sutter Auburn Faith Hospital
  - Auburn、California、美国、95603
    - Sutter Cancer Centers Radiation Oncology Services-Auburn
  - Berkeley、California、美国、94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Berkeley、California、美国、94702
    - UCSF Cancer Center - Berkeley
  - Beverly Hills、California、美国、90211
    - Tower Cancer Research Foundation
  - Burbank、California、美国、91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Cameron Park、California、美国、95682
    - Sutter Cancer Centers Radiation Oncology Services-Cameron Park
  - Carmichael、California、美国、95608
    - Mercy San Juan Medical Center
  - Carmichael、California、美国、95608
    - Mercy Cancer Center - Carmichael
  - Castro Valley、California、美国、94546
    - Eden Hospital Medical Center
  - Clovis、California、美国、93611
    - Community Cancer Institute
  - Concord、California、美国、94520
    - John Muir Medical Center-Concord
  - Costa Mesa、California、美国、92627
    - UC Irvine Health Cancer Center-Newport
  - Davis、California、美国、95616
    - Sutter Davis Hospital
  - Duarte、California、美国、91010
    - City of Hope Comprehensive Cancer Center
  - Dublin、California、美国、94568
    - Kaiser Permanente Dublin
  - Dublin、California、美国、94568
    - Epic Care-Dublin
  - Elk Grove、California、美国、95758
    - Mercy Cancer Center - Elk Grove
  - Emeryville、California、美国、94608
    - Bay Area Breast Surgeons Inc
  - Emeryville、California、美国、94608
    - Epic Care Partners in Cancer Care
  - Fremont、California、美国、94538
    - Kaiser Permanente-Fremont
  - Fremont、California、美国、94538
    - Washington Hospital
  - Fremont、California、美国、94538
    - Palo Alto Medical Foundation-Fremont
  - Fresno、California、美国、93720
    - Kaiser Permanente-Fresno
  - Fullerton、California、美国、92835
    - Saint Jude Medical Center
  - Irvine、California、美国、92618
    - City of Hope at Irvine Lennar
  - Irvine、California、美国、92612
    - UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
  - Los Angeles、California、美国、90033
    - USC / Norris Comprehensive Cancer Center
  - Los Angeles、California、美国、90048
    - Cedars Sinai Medical Center
  - Los Angeles、California、美国、90020
    - Keck Medicine of USC Koreatown
  - Los Angeles、California、美国、90033
    - Los Angeles General Medical Center
  - Martinez、California、美国、94553-3156
    - Contra Costa Regional Medical Center
  - Modesto、California、美国、95355
    - Memorial Medical Center
  - Modesto、California、美国、95356
    - Kaiser Permanente-Modesto
  - Mountain View、California、美国、94040
    - Palo Alto Medical Foundation-Camino Division
  - Mountain View、California、美国、94040
    - Palo Alto Medical Foundation-Gynecologic Oncology
  - Newport Beach、California、美国、92663
    - USC Norris Oncology/Hematology-Newport Beach
  - Newport Beach、California、美国、92660
    - City of Hope Newport Beach
  - Oakland、California、美国、94611
    - Kaiser Permanente-Oakland
  - Oakland、California、美国、94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland、California、美国、94609
    - Bay Area Tumor Institute
  - Orange、California、美国、92868
    - UC Irvine Health/Chao Family Comprehensive Cancer Center
  - Orange、California、美国、92868
    - Saint Joseph Hospital - Orange
  - Palm Springs、California、美国、92262
    - Desert Regional Medical Center
  - Palo Alto、California、美国、94304
    - Stanford Cancer Institute Palo Alto
  - Palo Alto、California、美国、94301
    - Palo Alto Medical Foundation Health Care
  - Pasadena、California、美国、91105
    - Huntington Memorial Hospital
  - Pasadena、California、美国、91105
    - Keck Medical Center of USC Pasadena
  - Rancho Mirage、California、美国、92270
    - Eisenhower Medical Center
  - Rocklin、California、美国、95765
    - Mercy Cancer Center - Rocklin
  - Roseville、California、美国、95661
    - Kaiser Permanente-Roseville
  - Roseville、California、美国、95661
    - Sutter Cancer Centers Radiation Oncology Services-Roseville
  - Roseville、California、美国、95661
    - Sutter Roseville Medical Center
  - Sacramento、California、美国、95816
    - Sutter Medical Center Sacramento
  - Sacramento、California、美国、95817
    - University of California Davis Comprehensive Cancer Center
  - Sacramento、California、美国、95814
    - Kaiser Permanente Downtown Commons
  - Sacramento、California、美国、95823
    - Kaiser Permanente-South Sacramento
  - Sacramento、California、美国、95816
    - Mercy Cancer Center - Sacramento
  - Salinas、California、美国、93901
    - Salinas Valley Memorial
  - San Francisco、California、美国、94115
    - Kaiser Permanente-San Francisco
  - San Francisco、California、美国、94158
    - UCSF Medical Center-Mission Bay
  - San Francisco、California、美国、94115
    - California Pacific Medical Center-Pacific Campus
  - San Francisco、California、美国、94110
    - Zuckerberg San Francisco General Hospital
  - San Jose、California、美国、95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Jose、California、美国、95124
    - Stanford Cancer Center South Bay
  - San Leandro、California、美国、94577
    - Kaiser Permanente San Leandro
  - San Luis Obispo、California、美国、93401
    - Pacific Central Coast Health Center-San Luis Obispo
  - San Mateo、California、美国、94402
    - UCSF Cancer Center - San Mateo
  - San Rafael、California、美国、94903
    - Kaiser San Rafael-Gallinas
  - Santa Clara、California、美国、95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Cruz、California、美国、95065
    - Palo Alto Medical Foundation-Santa Cruz
  - Santa Maria、California、美国、93444
    - Mission Hope Medical Oncology - Santa Maria
  - Santa Monica、California、美国、90404
    - Saint John's Cancer Institute
  - Santa Rosa、California、美国、95403
    - Kaiser Permanente-Santa Rosa
  - Santa Rosa、California、美国、95403
    - Sutter Pacific Medical Foundation
  - Santa Rosa、California、美国、95403
    - Providence Medical Foundation - Santa Rosa
  - Santa Rosa、California、美国、95405
    - Providence Santa Rosa Memorial Hospital
  - South Pasadena、California、美国、91030
    - City of Hope South Pasadena
  - South San Francisco、California、美国、94080
    - Kaiser Permanente-South San Francisco
  - St. Helena、California、美国、94574
    - Saint Helena Hospital
  - Sunnyvale、California、美国、94086
    - Palo Alto Medical Foundation-Sunnyvale
  - Torrance、California、美国、90505
    - Torrance Memorial Physician Network - Cancer Care
  - Torrance、California、美国、90503
    - City of Hope South Bay
  - Upland、California、美国、91786
    - City of Hope Upland
  - Vacaville、California、美国、95687
    - Sutter Cancer Centers Radiation Oncology Services-Vacaville
  - Vallejo、California、美国、94589
    - Kaiser Permanente-Vallejo
  - Vallejo、California、美国、94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek、California、美国、94596
    - Kaiser Permanente-Walnut Creek
  - Walnut Creek、California、美国、94598
    - John Muir Medical Center-Walnut Creek
  - Walnut Creek、California、美国、94597
    - Epic Care Cyberknife Center
  - Woodland、California、美国、95695
    - Woodland Memorial Hospital
- Colorado
  - Aurora、Colorado、美国、80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora、Colorado、美国、80012
    - The Medical Center of Aurora
  - Aurora、Colorado、美国、80045
    - UCHealth University of Colorado Hospital
  - Boulder、Colorado、美国、80303
    - Boulder Community Foothills Hospital
  - Boulder、Colorado、美国、80304
    - Rocky Mountain Cancer Centers-Boulder
  - Centennial、Colorado、美国、80112
    - Rocky Mountain Cancer Centers - Centennial
  - Colorado Springs、Colorado、美国、80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs、Colorado、美国、80909
    - UCHealth Memorial Hospital Central
  - Colorado Springs、Colorado、美国、80907
    - Rocky Mountain Cancer Centers-Penrose
  - Colorado Springs、Colorado、美国、80920
    - Memorial Hospital North
  - Denver、Colorado、美国、80210
    - Porter Adventist Hospital
  - Denver、Colorado、美国、80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver、Colorado、美国、80218
    - SCL Health Saint Joseph Hospital
  - Denver、Colorado、美国、80220
    - Rose Medical Center
  - Denver、Colorado、美国、80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver、Colorado、美国、80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver、Colorado、美国、80218
    - Colorado Blood Cancer Institute
  - Denver、Colorado、美国、80204
    - Cancer Center of Colorado at Sloan's Lake
  - Denver、Colorado、美国、80209
    - The Women's Imaging Center
  - Denver、Colorado、美国、80206
    - National Jewish Health-Main Campus
  - Denver、Colorado、美国、80220
    - Western Surgical Care
  - Denver、Colorado、美国、80206
    - UCHealth - Cherry Creek
  - Durango、Colorado、美国、81301
    - Mercy Medical Center
  - Durango、Colorado、美国、81301
    - Southwest Oncology PC
  - Edwards、Colorado、美国、81632
    - Shaw Cancer Center
  - Englewood、Colorado、美国、80113
    - Mountain Blue Cancer Care Center - Swedish
  - Englewood、Colorado、美国、80113
    - Swedish Medical Center
  - Englewood、Colorado、美国、80113
    - Rocky Mountain Cancer Centers - Swedish
  - Englewood、Colorado、美国、80113
    - The Melanoma and Skin Cancer Institute
  - Fort Collins、Colorado、美国、80524
    - Poudre Valley Hospital
  - Fort Collins、Colorado、美国、80528
    - Cancer Care and Hematology-Fort Collins
  - Golden、Colorado、美国、80401
    - National Jewish Health-Western Hematology Oncology
  - Golden、Colorado、美国、80401
    - SCL Health Cancer Centers of Colorado - Lutheran Medical Center
  - Grand Junction、Colorado、美国、81501
    - Saint Mary's Hospital and Regional Medical Center
  - Grand Junction、Colorado、美国、81505
    - Grand Valley Oncology
  - Greeley、Colorado、美国、80631
    - UCHealth Greeley Hospital
  - Greeley、Colorado、美国、80631
    - Banner North Colorado Medical Center
  - Highlands Ranch、Colorado、美国、80129
    - UCHealth Highlands Ranch Hospital
  - Lafayette、Colorado、美国、80026
    - Good Samaritan Medical Center
  - Lakewood、Colorado、美国、80228
    - Saint Anthony Hospital
  - Lakewood、Colorado、美国、80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Littleton、Colorado、美国、80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton、Colorado、美国、80122
    - Littleton Adventist Hospital
  - Lone Tree、Colorado、美国、80124
    - Sky Ridge Medical Center
  - Lone Tree、Colorado、美国、80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Lone Tree、Colorado、美国、80124
    - UCHealth Lone Tree Health Center
  - Longmont、Colorado、美国、80501
    - Longmont United Hospital
  - Longmont、Colorado、美国、80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland、Colorado、美国、80538
    - Medical Center of the Rockies
  - Loveland、Colorado、美国、80539
    - Banner McKee Medical Center
  - Parker、Colorado、美国、80138
    - Parker Adventist Hospital
  - Pueblo、Colorado、美国、81004
    - Saint Mary Corwin Medical Center
  - Thornton、Colorado、美国、80260
    - Rocky Mountain Cancer Centers-Thornton
  - Thornton、Colorado、美国、80260
    - National Jewish Health-Northern Hematology Oncology
  - Wheat Ridge、Colorado、美国、80033
    - SCL Health Lutheran Medical Center
- Connecticut
  - Bridgeport、Connecticut、美国、06606
    - Hartford HealthCare - Saint Vincent's Medical Center
  - Danbury、Connecticut、美国、06810
    - Danbury Hospital
  - Fairfield、Connecticut、美国、06824
    - Smilow Cancer Hospital Care Center-Fairfield
  - Glastonbury、Connecticut、美国、06033
    - Smilow Cancer Hospital Care Center at Glastonbury
  - Hartford、Connecticut、美国、06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Hartford、Connecticut、美国、06102
    - Hartford Hospital
  - Meriden、Connecticut、美国、06451
    - Midstate Medical Center
  - New Britain、Connecticut、美国、06050
    - The Hospital of Central Connecticut
  - New Haven、Connecticut、美国、06520
    - Yale University
  - North Haven、Connecticut、美国、06473
    - Yale-New Haven Hospital North Haven Medical Center
  - Norwalk、Connecticut、美国、06856
    - Norwalk Hospital
  - Stamford、Connecticut、美国、06904
    - Stamford Hospital/Bennett Cancer Center
  - Torrington、Connecticut、美国、06790
    - Smilow Cancer Hospital-Torrington Care Center
  - Trumbull、Connecticut、美国、06611
    - Smilow Cancer Hospital Care Center-Trumbull
  - Waterbury、Connecticut、美国、06708
    - Smilow Cancer Hospital-Waterbury Care Center
  - Waterford、Connecticut、美国、06385
    - Smilow Cancer Hospital Care Center - Waterford
- Delaware
  - Frankford、Delaware、美国、19945
    - Beebe South Coastal Health Campus
  - Lewes、Delaware、美国、19958
    - Beebe Medical Center
  - Newark、Delaware、美国、19713
    - Helen F Graham Cancer Center
  - Newark、Delaware、美国、19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark、Delaware、美国、19713
    - Medical Oncology Hematology Consultants PA
  - Newark、Delaware、美国、19718
    - Christiana Care Health System-Christiana Hospital
  - Rehoboth Beach、Delaware、美国、19971
    - Beebe Health Campus
  - Seaford、Delaware、美国、19973
    - TidalHealth Nanticoke / Allen Cancer Center
  - Wilmington、Delaware、美国、19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington D.C.、District of Columbia、美国、20010
    - MedStar Washington Hospital Center
  - Washington D.C.、District of Columbia、美国、20002
    - Kaiser Permanente-Capitol Hill Medical Center
  - Washington D.C.、District of Columbia、美国、20007
    - MedStar Georgetown University Hospital
  - Washington D.C.、District of Columbia、美国、20016
    - Sibley Memorial Hospital
- Florida
  - Altamonte Springs、Florida、美国、32701
    - AdventHealth Altamonte
  - Aventura、Florida、美国、33180
    - Mount Sinai Comprehensive Cancer Center at Aventura
  - Aventura、Florida、美国、33180
    - UM Sylvester Comprehensive Cancer Center at Aventura
  - Boca Raton、Florida、美国、33486
    - Boca Raton Regional Hospital
  - Celebration、Florida、美国、34747
    - AdventHealth Celebration
  - Clearwater、Florida、美国、33756
    - Morton Plant Hospital
  - Coral Gables、Florida、美国、33146
    - UM Sylvester Comprehensive Cancer Center at Coral Gables
  - Deerfield Beach、Florida、美国、33442
    - UM Sylvester Comprehensive Cancer Center at Deerfield Beach
  - Fort Lauderdale、Florida、美国、33308
    - Holy Cross Hospital
  - Hollywood、Florida、美国、33021
    - Memorial Regional Hospital/Joe DiMaggio Children's Hospital
  - Jacksonville、Florida、美国、32224-9980
    - Mayo Clinic in Florida
  - Kissimmee、Florida、美国、34744
    - AdventHealth Kissimmee
  - Miami、Florida、美国、33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami、Florida、美国、33176
    - UM Sylvester Comprehensive Cancer Center at Kendall
  - Miami Beach、Florida、美国、33140
    - Mount Sinai Medical Center
  - Orlando、Florida、美国、32806
    - Orlando Health Cancer Institute
  - Orlando、Florida、美国、32803
    - AdventHealth Orlando
  - Orlando、Florida、美国、32803
    - AdventHealth Medical Group Urology at Orlando
  - Orlando、Florida、美国、32822
    - AdventHealth East Orlando
  - Pembroke Pines、Florida、美国、33028
    - Memorial Hospital West
  - Pensacola、Florida、美国、32504
    - Sacred Heart Hospital
  - Plantation、Florida、美国、33324
    - UM Sylvester Comprehensive Cancer Center at Plantation
  - Safety Harbor、Florida、美国、34695
    - Mease Countryside Hospital
  - St. Petersburg、Florida、美国、33705
    - Saint Anthony's Hospital Cancer Care Center
  - Tampa、Florida、美国、33606
    - Tampa General Hospital
  - Tampa、Florida、美国、33607
    - Saint Joseph's Hospital/Children's Hospital-Tampa
  - Winter Haven、Florida、美国、33881
    - Winter Haven Hospital
  - Winter Park、Florida、美国、32792
    - AdventHealth Winter Park
- Georgia
  - Albany、Georgia、美国、31701
    - Phoebe Putney Memorial Hospital
  - Athens、Georgia、美国、30607
    - University Cancer and Blood Center LLC
  - Atlanta、Georgia、美国、30308
    - Emory University Hospital Midtown
  - Atlanta、Georgia、美国、30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta、Georgia、美国、30342
    - Emory Saint Joseph's Hospital
  - Atlanta、Georgia、美国、30303
    - Grady Health System
  - Atlanta、Georgia、美国、30342
    - Northside Hospital
  - Augusta、Georgia、美国、30901
    - Augusta Oncology Associates PC-D'Antignac
  - Augusta、Georgia、美国、30909
    - Augusta Oncology Associates PC-Wheeler
  - Decatur、Georgia、美国、30033
    - Atlanta VA Medical Center
  - Duluth、Georgia、美国、30096
    - Northside Hospital - Duluth
  - Lawrenceville、Georgia、美国、30046
    - Northside Hospital - Gwinnett
  - Newnan、Georgia、美国、30265
    - CTCA at Southeastern Regional Medical Center
  - Savannah、Georgia、美国、31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Savannah、Georgia、美国、31404
    - Memorial Health University Medical Center
  - Savannah、Georgia、美国、31404
    - Summit Cancer Care-Memorial
  - Snellville、Georgia、美国、30078
    - Suburban Hematology Oncology Associates - Snellville
- Hawaii
  - Hilo、Hawaii、美国、96720
    - Island Urology-Hilo
  - Honolulu、Hawaii、美国、96813
    - Queen's Medical Center
  - Honolulu、Hawaii、美国、96817
    - The Cancer Center of Hawaii-Liliha
  - Honolulu、Hawaii、美国、96813
    - Hawaii Cancer Care Inc - Waterfront Plaza
  - Honolulu、Hawaii、美国、96813
    - Queen's Cancer Cenrer - POB I
  - Honolulu、Hawaii、美国、96813
    - Straub Clinic and Hospital
  - Honolulu、Hawaii、美国、96813
    - University of Hawaii Cancer Center
  - Honolulu、Hawaii、美国、96817
    - Hawaii Cancer Care Inc-Liliha
  - Honolulu、Hawaii、美国、96817
    - Kuakini Medical Center
  - Honolulu、Hawaii、美国、96817
    - Queen's Cancer Center - Kuakini
  - Honolulu、Hawaii、美国、96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu、Hawaii、美国、96813
    - Island Urology
  - Honolulu、Hawaii、美国、96819
    - Kaiser Permanente Moanalua Medical Center
  - Lihue、Hawaii、美国、96766
    - Wilcox Memorial Hospital and Kauai Medical Clinic
  - ‘Aiea、Hawaii、美国、96701
    - Hawaii Cancer Care - Westridge
  - ‘Aiea、Hawaii、美国、96701
    - Pali Momi Medical Center
  - ‘Aiea、Hawaii、美国、96701
    - Queen's Cancer Center - Pearlridge
  - ‘Aiea、Hawaii、美国、96701
    - The Cancer Center of Hawaii-Pali Momi
- Idaho
  - Boise、Idaho、美国、83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise、Idaho、美国、83712
    - Saint Luke's Cancer Institute - Boise
  - Caldwell、Idaho、美国、83605
    - Saint Alphonsus Cancer Care Center-Caldwell
  - Coeur d'Alene、Idaho、美国、83814
    - Kootenai Health - Coeur d'Alene
  - Emmett、Idaho、美国、83617
    - Walter Knox Memorial Hospital
  - Fruitland、Idaho、美国、83619
    - Saint Luke's Cancer Institute - Fruitland
  - Meridian、Idaho、美国、83642
    - Idaho Urologic Institute-Meridian
  - Meridian、Idaho、美国、83642
    - Saint Luke's Cancer Institute - Meridian
  - Nampa、Idaho、美国、83686
    - Saint Luke's Cancer Institute - Nampa
  - Nampa、Idaho、美国、83687
    - Saint Alphonsus Cancer Care Center-Nampa
  - Post Falls、Idaho、美国、83854
    - Kootenai Clinic Cancer Services - Post Falls
  - Sandpoint、Idaho、美国、83864
    - Kootenai Clinic Cancer Services - Sandpoint
  - Twin Falls、Idaho、美国、83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Alton、Illinois、美国、62002
    - Saint Anthony's Health
  - Arlington Heights、Illinois、美国、60005
    - Northwest Community Hospital
  - Aurora、Illinois、美国、60504
    - Rush - Copley Medical Center
  - Barrington、Illinois、美国、60010
    - Advocate Good Shepherd Hospital
  - Bloomington、Illinois、美国、61704
    - Illinois CancerCare-Bloomington
  - Canton、Illinois、美国、61520
    - Illinois CancerCare-Canton
  - Carbondale、Illinois、美国、62902
    - Memorial Hospital of Carbondale
  - Carterville、Illinois、美国、62918
    - SIH Cancer Institute
  - Carthage、Illinois、美国、62321
    - Illinois CancerCare-Carthage
  - Centralia、Illinois、美国、62801
    - Centralia Oncology Clinic
  - Chicago、Illinois、美国、60611
    - Northwestern University
  - Chicago、Illinois、美国、60612
    - Rush University Medical Center
  - Chicago、Illinois、美国、60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago、Illinois、美国、60612
    - University of Illinois
  - Chicago、Illinois、美国、60612
    - John H Stroger Jr Hospital of Cook County
  - Chicago、Illinois、美国、60608
    - Mount Sinai Hospital Medical Center
  - Chicago、Illinois、美国、60625
    - Swedish Covenant Hospital
  - Chicago、Illinois、美国、60657
    - Advocate Illinois Masonic Medical Center
  - Crystal Lake、Illinois、美国、60014
    - AMG Crystal Lake - Oncology
  - Danville、Illinois、美国、61832
    - Carle at The Riverfront
  - DeKalb、Illinois、美国、60115
    - Northwestern Medicine Cancer Center Kishwaukee
  - Decatur、Illinois、美国、62526
    - Decatur Memorial Hospital
  - Decatur、Illinois、美国、62526
    - Cancer Care Specialists of Illinois - Decatur
  - Dixon、Illinois、美国、61021
    - Illinois CancerCare-Dixon
  - Downers Grove、Illinois、美国、60515
    - Advocate Good Samaritan Hospital
  - Effingham、Illinois、美国、62401
    - Crossroads Cancer Center
  - Effingham、Illinois、美国、62401
    - Carle Physician Group-Effingham
  - Elgin、Illinois、美国、60123
    - Advocate Sherman Hospital
  - Eureka、Illinois、美国、61530
    - Illinois CancerCare-Eureka
  - Evanston、Illinois、美国、60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Galesburg、Illinois、美国、61401
    - Western Illinois Cancer Treatment Center
  - Galesburg、Illinois、美国、61401
    - Illinois CancerCare-Galesburg
  - Geneva、Illinois、美国、60134
    - Northwestern Medicine Cancer Center Delnor
  - Glenview、Illinois、美国、60026
    - NorthShore University HealthSystem-Glenbrook Hospital
  - Glenview、Illinois、美国、60026
    - Northwestern Medicine Glenview Outpatient Center
  - Grayslake、Illinois、美国、60030
    - Northwestern Medicine Grayslake Outpatient Center
  - Harvey、Illinois、美国、60426
    - Ingalls Memorial Hospital
  - Hazel Crest、Illinois、美国、60429
    - Advocate South Suburban Hospital
  - Highland Park、Illinois、美国、60035
    - NorthShore University HealthSystem-Highland Park Hospital
  - Kewanee、Illinois、美国、61443
    - Illinois CancerCare-Kewanee Clinic
  - Lake Forest、Illinois、美国、60045
    - Northwestern Medicine Lake Forest Hospital
  - Libertyville、Illinois、美国、60048
    - Condell Memorial Hospital
  - Libertyville、Illinois、美国、60048
    - AMG Libertyville - Oncology
  - Macomb、Illinois、美国、61455
    - Illinois CancerCare-Macomb
  - Mattoon、Illinois、美国、61938
    - Carle Physician Group-Mattoon/Charleston
  - Mount Vernon、Illinois、美国、62864
    - Good Samaritan Regional Health Center
  - New Lenox、Illinois、美国、60451
    - UC Comprehensive Cancer Center at Silver Cross
  - O'Fallon、Illinois、美国、62269
    - Cancer Care Center of O'Fallon
  - Oak Lawn、Illinois、美国、60453-2699
    - Advocate Christ Medical Center
  - Orland Park、Illinois、美国、60462
    - University of Chicago Medicine-Orland Park
  - Orland Park、Illinois、美国、60462
    - Northwestern Medicine Orland Park
  - Ottawa、Illinois、美国、61350
    - Illinois CancerCare-Ottawa Clinic
  - Park Ridge、Illinois、美国、60068
    - Advocate Lutheran General Hospital
  - Pekin、Illinois、美国、61554
    - Illinois CancerCare-Pekin
  - Pekin、Illinois、美国、61554
    - OSF Saint Francis Radiation Oncology at Pekin
  - Peoria、Illinois、美国、61636
    - Methodist Medical Center of Illinois
  - Peoria、Illinois、美国、61637
    - OSF Saint Francis Medical Center
  - Peoria、Illinois、美国、61615
    - Illinois CancerCare-Peoria
  - Peoria、Illinois、美国、61615
    - OSF Saint Francis Radiation Oncology at Peoria Cancer Center
  - Peru、Illinois、美国、61354
    - Illinois CancerCare-Peru
  - Peru、Illinois、美国、61354
    - Valley Radiation Oncology
  - Princeton、Illinois、美国、61356
    - Illinois CancerCare-Princeton
  - Rockford、Illinois、美国、61108
    - OSF Saint Anthony Medical Center
  - Rockford、Illinois、美国、61114
    - UW Health Carbone Cancer Center Rockford
  - Shiloh、Illinois、美国、62269
    - Memorial Hospital East
  - Silvis、Illinois、美国、61282
    - Genesis Cancer Center - Silvis
  - Springfield、Illinois、美国、62781
    - Memorial Medical Center
  - Springfield、Illinois、美国、62702
    - Southern Illinois University School of Medicine
  - Springfield、Illinois、美国、62702
    - Springfield Clinic
  - Urbana、Illinois、美国、61801
    - Carle Cancer Center
  - Urbana、Illinois、美国、61801
    - The Carle Foundation Hospital
  - Warrenville、Illinois、美国、60555
    - Northwestern Medicine Cancer Center Warrenville
  - Washington、Illinois、美国、61571
    - Illinois CancerCare - Washington
  - Yorkville、Illinois、美国、60560
    - Rush-Copley Healthcare Center
- Indiana
  - Carmel、Indiana、美国、46032
    - IU Health North Hospital
  - Indianapolis、Indiana、美国、46237
    - Franciscan Health Indianapolis
  - Indianapolis、Indiana、美国、46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis、Indiana、美国、46219
    - Community Cancer Center East
  - Indianapolis、Indiana、美国、46227
    - Community Cancer Center South
  - Indianapolis、Indiana、美国、46256
    - Community Cancer Center North
  - Indianapolis、Indiana、美国、46202
    - Sidney and Lois Eskenazi Hospital
  - Kokomo、Indiana、美国、46904
    - Community Howard Regional Health
  - Lafayette、Indiana、美国、47905
    - Franciscan Saint Elizabeth Health - Lafayette East
  - Michigan City、Indiana、美国、46360
    - Woodland Cancer Care Center
  - Mooresville、Indiana、美国、46158
    - Franciscan Health Mooresville
  - Richmond、Indiana、美国、47374
    - Reid Health
  - South Bend、Indiana、美国、46601
    - Memorial Hospital of South Bend
- Iowa
  - Ames、Iowa、美国、50010
    - Mary Greeley Medical Center
  - Ames、Iowa、美国、50010
    - McFarland Clinic - Ames
  - Ankeny、Iowa、美国、50023
    - Mission Cancer and Blood - Ankeny
  - Boone、Iowa、美国、50036
    - McFarland Clinic - Boone
  - Carroll、Iowa、美国、51401
    - Saint Anthony Regional Hospital
  - Cedar Rapids、Iowa、美国、52403
    - Mercy Hospital
  - Cedar Rapids、Iowa、美国、52403
    - Oncology Associates at Mercy Medical Center
  - Cedar Rapids、Iowa、美国、52402
    - Physicians' Clinic of Iowa PC
  - Clive、Iowa、美国、50325
    - Mercy Cancer Center-West Lakes
  - Clive、Iowa、美国、50325
    - Mission Cancer and Blood - West Des Moines
  - Council Bluffs、Iowa、美国、51503
    - Alegent Health Mercy Hospital
  - Council Bluffs、Iowa、美国、51503
    - Heartland Oncology and Hematology LLP
  - Council Bluffs、Iowa、美国、51503
    - Methodist Jennie Edmundson Hospital
  - Creston、Iowa、美国、50801
    - Greater Regional Medical Center
  - Davenport、Iowa、美国、52803
    - Genesis Medical Center - East Campus
  - Davenport、Iowa、美国、52804
    - Genesis Cancer Care Institute
  - Davenport、Iowa、美国、52807
    - Iowa Cancer Specialists
  - Des Moines、Iowa、美国、50309
    - Iowa Methodist Medical Center
  - Des Moines、Iowa、美国、50314
    - Mercy Medical Center - Des Moines
  - Des Moines、Iowa、美国、50314
    - Broadlawns Medical Center
  - Des Moines、Iowa、美国、50314
    - Mission Cancer and Blood - Laurel
  - Des Moines、Iowa、美国、50316
    - Iowa Lutheran Hospital
  - Des Moines、Iowa、美国、50309
    - Mission Cancer and Blood - Des Moines
  - Fort Dodge、Iowa、美国、50501
    - Trinity Regional Medical Center
  - Fort Dodge、Iowa、美国、50501
    - McFarland Clinic - Trinity Cancer Center
  - Jefferson、Iowa、美国、50129
    - McFarland Clinic - Jefferson
  - Marshalltown、Iowa、美国、50158
    - McFarland Clinic - Marshalltown
  - Sioux City、Iowa、美国、51101
    - Siouxland Regional Cancer Center
  - West Des Moines、Iowa、美国、50266-7700
    - Methodist West Hospital
  - West Des Moines、Iowa、美国、50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Chanute、Kansas、美国、66720
    - Cancer Center of Kansas - Chanute
  - Dodge City、Kansas、美国、67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado、Kansas、美国、67042
    - Cancer Center of Kansas - El Dorado
  - Garden City、Kansas、美国、67846
    - Central Care Cancer Center - Garden City
  - Great Bend、Kansas、美国、67530
    - Central Care Cancer Center - Great Bend
  - Hays、Kansas、美国、67601
    - HaysMed
  - Independence、Kansas、美国、67301
    - Cancer Center of Kansas-Independence
  - Kingman、Kansas、美国、67068
    - Cancer Center of Kansas-Kingman
  - Lawrence、Kansas、美国、66044
    - Lawrence Memorial Hospital
  - Liberal、Kansas、美国、67905
    - Cancer Center of Kansas-Liberal
  - Manhattan、Kansas、美国、66502
    - Cancer Center of Kansas-Manhattan
  - McPherson、Kansas、美国、67460
    - Cancer Center of Kansas - McPherson
  - Newton、Kansas、美国、67114
    - Cancer Center of Kansas - Newton
  - Olathe、Kansas、美国、66061
    - Olathe Health Cancer Center
  - Overland Park、Kansas、美国、66210
    - University of Kansas Cancer Center-Overland Park
  - Overland Park、Kansas、美国、66209
    - Menorah Medical Center
  - Overland Park、Kansas、美国、66211
    - University of Kansas Hospital-Indian Creek Campus
  - Parsons、Kansas、美国、67357
    - Cancer Center of Kansas - Parsons
  - Pittsburg、Kansas、美国、66762
    - Ascension Via Christi - Pittsburg
  - Pittsburg、Kansas、美国、66762
    - Freeman Physician Group of Pittsburg
  - Pratt、Kansas、美国、67124
    - Cancer Center of Kansas - Pratt
  - Salina、Kansas、美国、67401
    - Salina Regional Health Center
  - Salina、Kansas、美国、67401
    - Cancer Center of Kansas - Salina
  - Topeka、Kansas、美国、66606
    - University of Kansas Health System Saint Francis Campus
  - Wellington、Kansas、美国、67152
    - Cancer Center of Kansas - Wellington
  - Westwood、Kansas、美国、66205
    - University of Kansas Hospital-Westwood Cancer Center
  - Wichita、Kansas、美国、67214
    - Ascension Via Christi Hospitals Wichita
  - Wichita、Kansas、美国、67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita、Kansas、美国、67214
    - Cancer Center of Kansas - Wichita
  - Winfield、Kansas、美国、67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Ashland、Kentucky、美国、41101
    - King's Daughter's Medical Center
  - Bardstown、Kentucky、美国、40004
    - Flaget Memorial Hospital
  - Corbin、Kentucky、美国、40701
    - Baptist Health Corbin
  - Corbin、Kentucky、美国、40701
    - Commonwealth Cancer Center-Corbin
  - Lexington、Kentucky、美国、40536
    - University of Kentucky/Markey Cancer Center
  - Lexington、Kentucky、美国、40504
    - Saint Joseph Radiation Oncology Resource Center
  - Lexington、Kentucky、美国、40509
    - Saint Joseph Hospital East
  - Lexington、Kentucky、美国、40503
    - Baptist Health Lexington
  - London、Kentucky、美国、40741
    - Saint Joseph London
  - Louisville、Kentucky、美国、40202
    - Jewish Hospital
  - Louisville、Kentucky、美国、40245
    - UofL Health Medical Center Northeast
  - Louisville、Kentucky、美国、40207
    - Baptist Health Louisville
  - Louisville、Kentucky、美国、40215
    - Saints Mary and Elizabeth Hospital
  - Shepherdsville、Kentucky、美国、40165
    - Jewish Hospital Medical Center South
- Louisiana
  - Metairie、Louisiana、美国、70006
    - East Jefferson General Hospital
  - New Orleans、Louisiana、美国、70112
    - University Medical Center New Orleans
  - New Orleans、Louisiana、美国、70112
    - Louisiana State University Health Science Center
  - Shreveport、Louisiana、美国、71103
    - LSU Health Sciences Center at Shreveport
- Maine
  - Augusta、Maine、美国、04330
    - Harold Alfond Center for Cancer Care
  - Biddeford、Maine、美国、04005
    - MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
  - Brewer、Maine、美国、04412
    - Lafayette Family Cancer Center-EMMC
  - Kennebunk、Maine、美国、04043
    - Maine Center for Cancer Medicine-Kennebunk
  - Sanford、Maine、美国、04073
    - MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
  - Scarborough、Maine、美国、04074
    - Maine Center for Cancer Medicine-Scarborough
  - South Portland、Maine、美国、04106
    - Maine Medical Partners - South Portland
  - Topsham、Maine、美国、04086
    - Maine Center for Cancer Medicine-Topsham
  - York Village、Maine、美国、03909
    - York Hospital
- Maryland
  - Annapolis、Maryland、美国、21401
    - Luminis Health Anne Arundel Medical Center
  - Baltimore、Maryland、美国、21237
    - MedStar Franklin Square Medical Center/Weinberg Cancer Institute
  - Baltimore、Maryland、美国、21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore、Maryland、美国、21215
    - Sinai Hospital of Baltimore
  - Baltimore、Maryland、美国、21204
    - Greater Baltimore Medical Center
  - Baltimore、Maryland、美国、21244
    - Kaiser Permanente-Woodlawn Medical Center
  - Baltimore、Maryland、美国、21239
    - MedStar Good Samaritan Hospital
  - Bel Air、Maryland、美国、21014
    - UM Upper Chesapeake Medical Center
  - Bethesda、Maryland、美国、20889-5600
    - Walter Reed National Military Medical Center
  - Cumberland、Maryland、美国、21502
    - UPMC Western Maryland
  - Easton、Maryland、美国、21601
    - University of Maryland Shore Medical Center at Easton
  - Gaithersburg、Maryland、美国、20879
    - Kaiser Permanente-Gaithersburg Medical Center
  - Kensington、Maryland、美国、20895
    - Kaiser Permanente - Kensington Medical Center
  - Largo、Maryland、美国、20774
    - Kaiser Permanente - Largo Medical Center
  - Lutherville、Maryland、美国、21093
    - Kaiser Permanente Lutherville - Timonium Medical Center
  - Olney、Maryland、美国、20832
    - Medstar Montgomery Medical Center
  - Westminster、Maryland、美国、21157
    - William E Kahlert Regional Cancer Center/Sinai Hospital
- Massachusetts
  - Beverly、Massachusetts、美国、01915
    - Beverly Hospital
  - Boston、Massachusetts、美国、02215
    - Beth Israel Deaconess Medical Center
  - Boston、Massachusetts、美国、02215
    - Dana-Farber Cancer Institute
  - Boston、Massachusetts、美国、02111
    - Tufts Medical Center
  - Boston、Massachusetts、美国、02118
    - Boston Medical Center
  - Burlington、Massachusetts、美国、01805
    - Lahey Hospital and Medical Center
  - Foxborough、Massachusetts、美国、02035
    - Dana-Farber Cancer Institute at Foxborough
  - Gloucester、Massachusetts、美国、01930
    - Addison Gilbert Hospital
  - Hyannis、Massachusetts、美国、02601
    - Cape Cod Hospital
  - Lowell、Massachusetts、美国、01854
    - Lowell General Hospital
  - Milford、Massachusetts、美国、01757
    - Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
  - Peabody、Massachusetts、美国、01960
    - Lahey Medical Center-Peabody
  - South Weymouth、Massachusetts、美国、02190
    - Dana-Farber/Brigham and Women's Cancer Center at South Shore
  - Winchester、Massachusetts、美国、01890
    - Winchester Hospital
  - Worcester、Massachusetts、美国、01655
    - UMass Memorial Medical Center - University Campus
- Michigan
  - Adrian、Michigan、美国、49221
    - Hickman Cancer Center
  - Ann Arbor、Michigan、美国、48109
    - University Of Michigan Comprehensive Cancer Center
  - Ann Arbor、Michigan、美国、48106
    - Trinity Health Saint Joseph Mercy Hospital Ann Arbor
  - Battle Creek、Michigan、美国、49017
    - Bronson Battle Creek
  - Brighton、Michigan、美国、48114
    - Trinity Health IHA Medical Group Hematology Oncology - Brighton
  - Brighton、Michigan、美国、48114
    - Trinity Health Medical Center - Brighton
  - Canton、Michigan、美国、48188
    - Trinity Health IHA Medical Group Hematology Oncology - Canton
  - Canton、Michigan、美国、48188
    - Trinity Health Medical Center - Canton
  - Caro、Michigan、美国、48723
    - Caro Cancer Center
  - Chelsea、Michigan、美国、48118
    - Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
  - Chelsea、Michigan、美国、48118
    - Chelsea Hospital
  - Clarkston、Michigan、美国、48346
    - Hematology Oncology Consultants-Clarkston
  - Clarkston、Michigan、美国、48346
    - Newland Medical Associates-Clarkston
  - Dearborn、Michigan、美国、48124
    - Corewell Health Dearborn Hospital
  - Detroit、Michigan、美国、48201
    - Wayne State University/Karmanos Cancer Institute
  - Detroit、Michigan、美国、48236
    - Ascension Saint John Hospital
  - East China、Michigan、美国、48054
    - Great Lakes Cancer Management Specialists-Doctors Park
  - Farmington Hills、Michigan、美国、48334
    - Weisberg Cancer Treatment Center
  - Farmington Hills、Michigan、美国、48336
    - Corewell Health Farmington Hills Hospital
  - Flint、Michigan、美国、48503
    - Hurley Medical Center
  - Flint、Michigan、美国、48503
    - Genesee Cancer and Blood Disease Treatment Center
  - Flint、Michigan、美国、48503
    - Genesee Hematology Oncology PC
  - Flint、Michigan、美国、48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids、Michigan、美国、49503
    - Trinity Health Grand Rapids Hospital
  - Grand Rapids、Michigan、美国、49503
    - Corewell Health Grand Rapids Hospitals - Butterworth Hospital
  - Grosse Pointe Woods、Michigan、美国、48236
    - Academic Hematology Oncology Specialists
  - Grosse Pointe Woods、Michigan、美国、48236
    - Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
  - Grosse Pointe Woods、Michigan、美国、48236
    - Michigan Breast Specialists-Grosse Pointe Woods
  - Kalamazoo、Michigan、美国、49007
    - West Michigan Cancer Center
  - Kalamazoo、Michigan、美国、49007
    - Bronson Methodist Hospital
  - Kalamazoo、Michigan、美国、49009
    - Ascension Borgess Cancer Center
  - Lansing、Michigan、美国、48912
    - University of Michigan Health - Sparrow Lansing
  - Livonia、Michigan、美国、48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Livonia、Michigan、美国、48154
    - Hope Cancer Clinic
  - Macomb、Michigan、美国、48044
    - Great Lakes Cancer Management Specialists-Macomb Medical Campus
  - Macomb、Michigan、美国、48044
    - Michigan Breast Specialists-Macomb Township
  - Marlette、Michigan、美国、48453
    - Saint Mary's Oncology/Hematology Associates of Marlette
  - Midland、Michigan、美国、48670
    - MyMichigan Medical Center Midland
  - Monroe、Michigan、美国、48162
    - Toledo Clinic Cancer Centers-Monroe
  - Muskegon、Michigan、美国、49444
    - Trinity Health Muskegon Hospital
  - Niles、Michigan、美国、49120
    - Corewell Health Lakeland Hospitals - Niles Hospital
  - Norton Shores、Michigan、美国、49444
    - Cancer and Hematology Centers of Western Michigan - Norton Shores
  - Novi、Michigan、美国、48374
    - Ascension Providence Hospitals - Novi
  - Pontiac、Michigan、美国、48341
    - Hope Cancer Center
  - Pontiac、Michigan、美国、48341
    - Newland Medical Associates-Pontiac
  - Pontiac、Michigan、美国、48341
    - Trinity Health Saint Joseph Mercy Oakland Hospital
  - Pontiac、Michigan、美国、48341
    - Michigan Healthcare Professionals Pontiac
  - Reed City、Michigan、美国、49677
    - Corewell Health Reed City Hospital
  - Royal Oak、Michigan、美国、48073
    - Corewell Health William Beaumont University Hospital
  - Saginaw、Michigan、美国、48601
    - Ascension Saint Mary's Hospital
  - Saginaw、Michigan、美国、48604
    - Oncology Hematology Associates of Saginaw Valley PC
  - Saint Joseph、Michigan、美国、49085
    - Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
  - Saint Joseph、Michigan、美国、49085
    - Corewell Health Lakeland Hospitals - Saint Joseph Hospital
  - Southfield、Michigan、美国、48075
    - Ascension Providence Hospitals - Southfield
  - Sterling Heights、Michigan、美国、48312
    - Bhadresh Nayak MD PC-Sterling Heights
  - Tawas City、Michigan、美国、48764
    - Ascension Saint Joseph Hospital
  - Traverse City、Michigan、美国、49684
    - Munson Medical Center
  - Troy、Michigan、美国、48085
    - Corewell Health Beaumont Troy Hospital
  - Warren、Michigan、美国、48093
    - Saint John Macomb-Oakland Hospital
  - Warren、Michigan、美国、48088
    - Advanced Breast Care Center PLLC
  - Warren、Michigan、美国、48093
    - Great Lakes Cancer Management Specialists-Macomb Professional Building
  - Warren、Michigan、美国、48093
    - Macomb Hematology Oncology PC
  - Warren、Michigan、美国、48093
    - Michigan Breast Specialists-Warren
  - West Branch、Michigan、美国、48661
    - Saint Mary's Oncology/Hematology Associates of West Branch
  - Wyoming、Michigan、美国、49519
    - University of Michigan Health - West
  - Ypsilanti、Michigan、美国、48197
    - Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
  - Ypsilanti、Michigan、美国、48106
    - Huron Gastroenterology PC
- Minnesota
  - Aitkin、Minnesota、美国、56431
    - Riverwood Healthcare Center
  - Bemidji、Minnesota、美国、56601
    - Sanford Joe Lueken Cancer Center
  - Brainerd、Minnesota、美国、56401
    - Essentia Health Saint Joseph's Medical Center
  - Burnsville、Minnesota、美国、55337
    - Fairview Ridges Hospital
  - Burnsville、Minnesota、美国、55337
    - Minnesota Oncology - Burnsville
  - Cambridge、Minnesota、美国、55008
    - Cambridge Medical Center
  - Coon Rapids、Minnesota、美国、55433
    - Mercy Hospital
  - Deer River、Minnesota、美国、56636
    - Essentia Health - Deer River Clinic
  - Detroit Lakes、Minnesota、美国、56501
    - Essentia Health Saint Mary's - Detroit Lakes Clinic
  - Duluth、Minnesota、美国、55805
    - Saint Luke's Hospital of Duluth
  - Duluth、Minnesota、美国、55805
    - Essentia Health Cancer Center
  - Duluth、Minnesota、美国、55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth、Minnesota、美国、55805
    - Miller-Dwan Hospital
  - Edina、Minnesota、美国、55435
    - Fairview Southdale Hospital
  - Fergus Falls、Minnesota、美国、56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fosston、Minnesota、美国、56542
    - Essentia Health - Fosston
  - Fridley、Minnesota、美国、55432
    - Unity Hospital
  - Hibbing、Minnesota、美国、55746
    - Essentia Health Hibbing Clinic
  - Maple Grove、Minnesota、美国、55369
    - Fairview Clinics and Surgery Center Maple Grove
  - Maplewood、Minnesota、美国、55109
    - Saint John's Hospital - Healtheast
  - Maplewood、Minnesota、美国、55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis、Minnesota、美国、55415
    - Hennepin County Medical Center
  - Minneapolis、Minnesota、美国、55407
    - Abbott-Northwestern Hospital
  - Minneapolis、Minnesota、美国、55454
    - Health Partners Inc
  - Monticello、Minnesota、美国、55362
    - Monticello Cancer Center
  - New Ulm、Minnesota、美国、56073
    - New Ulm Medical Center
  - Park Rapids、Minnesota、美国、56470
    - Essentia Health - Park Rapids
  - Princeton、Minnesota、美国、55371
    - Fairview Northland Medical Center
  - Robbinsdale、Minnesota、美国、55422
    - North Memorial Medical Health Center
  - Rochester、Minnesota、美国、55905
    - Mayo Clinic in Rochester
  - Saint Cloud、Minnesota、美国、56303
    - Coborn Cancer Center at Saint Cloud Hospital
  - Saint Louis Park、Minnesota、美国、55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Paul、Minnesota、美国、55101
    - Regions Hospital
  - Saint Paul、Minnesota、美国、55102
    - United Hospital
  - Sandstone、Minnesota、美国、55072
    - Essentia Health Sandstone
  - Shakopee、Minnesota、美国、55379
    - Saint Francis Regional Medical Center
  - Stillwater、Minnesota、美国、55082
    - Lakeview Hospital
  - Thief River Falls、Minnesota、美国、56701
    - Sanford Thief River Falls Medical Center
  - Virginia、Minnesota、美国、55792
    - Essentia Health Virginia Clinic
  - Waconia、Minnesota、美国、55387
    - Ridgeview Medical Center
  - Willmar、Minnesota、美国、56201
    - Rice Memorial Hospital
  - Woodbury、Minnesota、美国、55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Worthington、Minnesota、美国、56187
    - Sanford Cancer Center Worthington
  - Wyoming、Minnesota、美国、55092
    - Fairview Lakes Medical Center
- Mississippi
  - Columbus、Mississippi、美国、39705
    - Baptist Memorial Hospital and Cancer Center-Golden Triangle
  - Grenada、Mississippi、美国、38901
    - Baptist Cancer Center-Grenada
  - Jackson、Mississippi、美国、39216
    - University of Mississippi Medical Center
  - New Albany、Mississippi、美国、38652
    - Baptist Memorial Hospital and Cancer Center-Union County
  - Oxford、Mississippi、美国、38655
    - Baptist Memorial Hospital and Cancer Center-Oxford
  - Southhaven、Mississippi、美国、38671
    - Baptist Memorial Hospital and Cancer Center-Desoto
- Missouri
  - Ballwin、Missouri、美国、63011
    - Saint Louis Cancer and Breast Institute-Ballwin
  - Bolivar、Missouri、美国、65613
    - Central Care Cancer Center - Bolivar
  - Cape Girardeau、Missouri、美国、63703
    - Saint Francis Medical Center
  - Cape Girardeau、Missouri、美国、63703
    - Southeast Cancer Center
  - Chesterfield、Missouri、美国、63017
    - Saint Luke's Hospital
  - City of Saint Peters、Missouri、美国、63376
    - Siteman Cancer Center at Saint Peters Hospital
  - Columbia、Missouri、美国、65212
    - MU Health - University Hospital/Ellis Fischel Cancer Center
  - Creve Coeur、Missouri、美国、63141
    - Siteman Cancer Center at West County Hospital
  - Farmington、Missouri、美国、63640
    - Parkland Health Center - Farmington
  - Independence、Missouri、美国、64057
    - Centerpoint Medical Center LLC
  - Jefferson City、Missouri、美国、65109
    - MU Health Care Goldschmidt Cancer Center
  - Joplin、Missouri、美国、64804
    - Freeman Health System
  - Joplin、Missouri、美国、64804
    - Mercy Hospital Joplin
  - Kansas City、Missouri、美国、64154
    - University of Kansas Cancer Center - North
  - Kansas City、Missouri、美国、64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City、Missouri、美国、64132
    - Research Medical Center
  - Kansas City、Missouri、美国、64108
    - University Health Truman Medical Center
  - Lee's Summit、Missouri、美国、64064
    - University of Kansas Cancer Center - Lee's Summit
  - Lee's Summit、Missouri、美国、64086
    - Saint Luke's East - Lee's Summit
  - North Kansas City、Missouri、美国、64116
    - University of Kansas Cancer Center at North Kansas City Hospital
  - Rolla、Missouri、美国、65401
    - Delbert Day Cancer Institute at PCRMC
  - Rolla、Missouri、美国、65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Saint Joseph、Missouri、美国、64506
    - Heartland Regional Medical Center
  - Sainte Genevieve、Missouri、美国、63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield、Missouri、美国、65807
    - CoxHealth South Hospital
  - Springfield、Missouri、美国、65804
    - Mercy Hospital Springfield
  - St Louis、Missouri、美国、63110
    - Washington University School of Medicine
  - St Louis、Missouri、美国、63129
    - Siteman Cancer Center-South County
  - St Louis、Missouri、美国、63136
    - Siteman Cancer Center at Christian Hospital
  - St Louis、Missouri、美国、63131
    - Missouri Baptist Medical Center
  - St Louis、Missouri、美国、63141
    - Mercy Hospital Saint Louis
  - St Louis、Missouri、美国、63128
    - Mercy Hospital South
  - St Louis、Missouri、美国、63109
    - Saint Louis Cancer and Breast Institute-South City
  - Sullivan、Missouri、美国、63080
    - Missouri Baptist Sullivan Hospital
  - Sunset Hills、Missouri、美国、63127
    - BJC Outpatient Center at Sunset Hills
  - Washington、Missouri、美国、63090
    - Mercy Hospital Washington
- Montana
  - Anaconda、Montana、美国、59711
    - Community Hospital of Anaconda
  - Billings、Montana、美国、59101
    - Billings Clinic Cancer Center
  - Billings、Montana、美国、59101
    - Saint Vincent Healthcare
  - Billings、Montana、美国、59102
    - Saint Vincent Frontier Cancer Center
  - Bozeman、Montana、美国、59715
    - Bozeman Health Deaconess Hospital
  - Butte、Montana、美国、59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls、Montana、美国、59405
    - Great Falls Clinic
  - Great Falls、Montana、美国、59405
    - Benefis Sletten Cancer Institute
  - Kalispell、Montana、美国、59901
    - Kalispell Regional Medical Center
  - Missoula、Montana、美国、59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula、Montana、美国、59804
    - Community Medical Center
- Nebraska
  - Bellevue、Nebraska、美国、68123
    - Nebraska Medicine-Bellevue
  - Grand Island、Nebraska、美国、68803
    - Nebraska Cancer Specialists/Oncology Hematology West PC
  - Kearney、Nebraska、美国、68847
    - CHI Health Good Samaritan
  - Lincoln、Nebraska、美国、68510
    - Saint Elizabeth Regional Medical Center
  - Omaha、Nebraska、美国、68114
    - Nebraska Methodist Hospital
  - Omaha、Nebraska、美国、68198
    - University of Nebraska Medical Center
  - Omaha、Nebraska、美国、68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha、Nebraska、美国、68118
    - Nebraska Medicine-Village Pointe
  - Omaha、Nebraska、美国、68122
    - Alegent Health Immanuel Medical Center
  - Omaha、Nebraska、美国、68130
    - Alegent Health Lakeside Hospital
  - Omaha、Nebraska、美国、68131
    - Creighton University Medical Center
  - Omaha、Nebraska、美国、68114
    - Oncology Associates PC
  - Omaha、Nebraska、美国、68114
    - Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
  - Papillion、Nebraska、美国、68046
    - Midlands Community Hospital
- Nevada
  - Carson City、Nevada、美国、89703
    - Carson Tahoe Regional Medical Center
  - Henderson、Nevada、美国、89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson、Nevada、美国、89052
    - OptumCare Cancer Care at Seven Hills
  - Henderson、Nevada、美国、89052
    - Cancer and Blood Specialists-Henderson
  - Henderson、Nevada、美国、89052
    - Las Vegas Cancer Center-Henderson
  - Henderson、Nevada、美国、89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson、Nevada、美国、89074
    - GenesisCare USA - Henderson
  - Henderson、Nevada、美国、89052
    - Comprehensive Cancer Centers of Nevada-Horizon Ridge
  - Henderson、Nevada、美国、89074
    - Las Vegas Urology - Green Valley
  - Henderson、Nevada、美国、89074
    - Las Vegas Urology - Pebble
  - Henderson、Nevada、美国、89074
    - Urology Specialists of Nevada - Green Valley
  - Las Vegas、Nevada、美国、89144
    - Summerlin Hospital Medical Center
  - Las Vegas、Nevada、美国、89109
    - Sunrise Hospital and Medical Center
  - Las Vegas、Nevada、美国、89102
    - OptumCare Cancer Care at Charleston
  - Las Vegas、Nevada、美国、89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas、Nevada、美国、89109
    - GenesisCare USA - Las Vegas
  - Las Vegas、Nevada、美国、89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas、Nevada、美国、89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas、Nevada、美国、89128
    - OptumCare Cancer Care at MountainView
  - Las Vegas、Nevada、美国、89135
    - Alliance for Childhood Diseases/Cure 4 the Kids Foundation
  - Las Vegas、Nevada、美国、89144
    - Comprehensive Cancer Centers of Nevada - Town Center
  - Las Vegas、Nevada、美国、89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas、Nevada、美国、89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas、Nevada、美国、89148
    - OptumCare Cancer Care at Fort Apache
  - Las Vegas、Nevada、美国、89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas、Nevada、美国、89102
    - University Medical Center of Southern Nevada
  - Las Vegas、Nevada、美国、89128
    - GenesisCare USA - Vegas Tenaya
  - Las Vegas、Nevada、美国、89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas、Nevada、美国、89148
    - GenesisCare USA - Fort Apache
  - Las Vegas、Nevada、美国、89128
    - Ann M Wierman MD LTD
  - Las Vegas、Nevada、美国、89074
    - Las Vegas Urology - Pecos
  - Las Vegas、Nevada、美国、89102
    - Desert West Surgery
  - Las Vegas、Nevada、美国、89103
    - Hope Cancer Care of Nevada
  - Las Vegas、Nevada、美国、89106
    - Urology Specialists of Nevada - Central
  - Las Vegas、Nevada、美国、89113
    - Las Vegas Prostate Cancer Center
  - Las Vegas、Nevada、美国、89113
    - Las Vegas Urology - Sunset
  - Las Vegas、Nevada、美国、89128
    - Las Vegas Urology - Cathedral Rock
  - Las Vegas、Nevada、美国、89128
    - Las Vegas Urology - Smoke Ranch
  - Las Vegas、Nevada、美国、89128
    - Urology Specialists of Nevada - Northwest
  - Las Vegas、Nevada、美国、89169
    - University Cancer Center
  - Las Vegas、Nevada、美国、89113
    - Urology Specialists of Nevada - Southwest
  - Pahrump、Nevada、美国、89048
    - Hope Cancer Care of Nevada-Pahrump
  - Reno、Nevada、美国、89502
    - Renown Regional Medical Center
  - Reno、Nevada、美国、89503
    - Saint Mary's Regional Medical Center
  - Reno、Nevada、美国、89509
    - Radiation Oncology Associates
- New Hampshire
  - Concord、New Hampshire、美国、03301
    - New Hampshire Oncology Hematology PA-Concord
  - Lebanon、New Hampshire、美国、03756
    - Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
  - Manchester、New Hampshire、美国、03103
    - Solinsky Center for Cancer Care
- New Jersey
  - Berkeley Heights、New Jersey、美国、07922
    - Summit Medical Group
  - Camden、New Jersey、美国、08103
    - Cooper Hospital University Medical Center
  - Englewood、New Jersey、美国、07631
    - Englewood Hospital and Medical Center
  - Florham Park、New Jersey、美国、07932
    - Summit Health - Florham Park Campus
  - Hackensack、New Jersey、美国、07601
    - Hackensack University Medical Center
  - Hamilton、New Jersey、美国、08690
    - The Cancer Institute of New Jersey Hamilton
  - Jersey City、New Jersey、美国、07302
    - Jersey City Medical Center
  - Lakewood、New Jersey、美国、08701
    - Monmouth Medical Center Southern Campus
  - Livingston、New Jersey、美国、07039
    - Saint Barnabas Medical Center
  - Long Branch、New Jersey、美国、07740
    - Monmouth Medical Center
  - Morristown、New Jersey、美国、07960
    - Morristown Medical Center
  - New Brunswick、New Jersey、美国、08903
    - Rutgers Cancer Institute of New Jersey
  - Newark、New Jersey、美国、07101
    - Rutgers New Jersey Medical School
  - Newark、New Jersey、美国、07112
    - Newark Beth Israel Medical Center
  - Paterson、New Jersey、美国、07503
    - Saint Joseph's Regional Medical Center
  - Sewell、New Jersey、美国、08080
    - Sidney Kimmel Cancer Center Washington Township
  - Somerville、New Jersey、美国、08876
    - Robert Wood Johnson University Hospital Somerset
  - Summit、New Jersey、美国、07902
    - Overlook Hospital
  - Teaneck、New Jersey、美国、07666
    - Holy Name Hospital
  - Toms River、New Jersey、美国、08755
    - Community Medical Center
- New Mexico
  - Albuquerque、New Mexico、美国、87106
    - University of New Mexico Cancer Center
  - Albuquerque、New Mexico、美国、87110
    - Presbyterian Kaseman Hospital
  - Rio Rancho、New Mexico、美国、87124
    - Presbyterian Rust Medical Center/Jorgensen Cancer Center
- New York
  - Auburn、New York、美国、13021
    - Hematology Oncology Associates of Central New York-Auburn
  - Bay Shore、New York、美国、11706
    - Northwell Health Imbert Cancer Center
  - Buffalo、New York、美国、14263
    - Roswell Park Cancer Institute
  - East Hills、New York、美国、11548
    - The Cancer Institute at Saint Francis Hospital
  - East Syracuse、New York、美国、13057
    - Hematology Oncology Associates of Central New York-East Syracuse
  - Glens Falls、New York、美国、12801
    - Glens Falls Hospital
  - Jamaica、New York、美国、11432
    - Queens Hospital Center
  - Lake Success、New York、美国、11042
    - Northwell Health/Center for Advanced Medicine
  - Mineola、New York、美国、11501
    - NYU Langone Hospital - Long Island
  - Mount Kisco、New York、美国、10549
    - Northern Westchester Hospital
  - New York、New York、美国、10019
    - Mount Sinai West
  - New York、New York、美国、10029
    - Mount Sinai Hospital
  - New York、New York、美国、10032
    - NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
  - New York、New York、美国、10011
    - Mount Sinai Chelsea
  - New York、New York、美国、10016
    - Laura and Isaac Perlmutter Cancer Center at NYU Langone
  - New York、New York、美国、10021
    - Lenox Hill Hospital
  - New York、New York、美国、10065
    - Manhattan Eye Ear and Throat Hospital
  - Nyack、New York、美国、10960
    - Nyack Hospital
  - Poughkeepsie、New York、美国、12601
    - Vassar Brothers Medical Center
  - Rochester、New York、美国、14642
    - University of Rochester
  - Rochester、New York、美国、14623
    - Pluta Cancer Center
  - Sleepy Hollow、New York、美国、10591
    - Phelps Memorial Hospital Center
  - Stony Brook、New York、美国、11794
    - Stony Brook University Medical Center
  - Syracuse、New York、美国、13210
    - State University of New York Upstate Medical University
  - Syracuse、New York、美国、13215
    - Hematology Oncology Associates of Central New York-Onondaga Hill
  - Verona、New York、美国、13478
    - Upstate Cancer Center at Verona
  - West Islip、New York、美国、11795
    - Good Samaritan University Hospital
  - White Plains、New York、美国、10601
    - Dickstein Cancer Treatment Center
- North Carolina
  - Asheboro、North Carolina、美国、27203
    - Randolph Hospital
  - Asheboro、North Carolina、美国、27203
    - Cone Health Cancer Center at Asheboro
  - Asheboro、North Carolina、美国、27203
    - Randolph Health Cancer Center
  - Burlington、North Carolina、美国、27215
    - Cone Health Cancer Center at Alamance Regional
  - Cary、North Carolina、美国、27518
    - Rex Hematology Oncology Associates-Cary
  - Chapel Hill、North Carolina、美国、27599
    - UNC Lineberger Comprehensive Cancer Center
  - Charlotte、North Carolina、美国、28204
    - Novant Health Presbyterian Medical Center
  - Clinton、North Carolina、美国、28328
    - Southeastern Medical Oncology Center-Clinton
  - Durham、North Carolina、美国、27710
    - Duke University Medical Center
  - Garner、North Carolina、美国、27529
    - Rex Hematology Oncology Associates-Garner
  - Gastonia、North Carolina、美国、28054
    - CaroMont Regional Medical Center
  - Goldsboro、North Carolina、美国、27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Greensboro、North Carolina、美国、27403
    - Cone Health Cancer Center
  - Greensboro、North Carolina、美国、27410
    - Cone Health Cancer Center at Drawbridge Parkway
  - Greensboro、North Carolina、美国、27403
    - Novant Health Breast Surgery - Greensboro
  - Hillsborough、North Carolina、美国、27278
    - University of North Carolina-Hillsborough Campus
  - Huntersville、North Carolina、美国、28078
    - Novant Health Cancer Institute - Huntersville
  - Jacksonville、North Carolina、美国、28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Kernersville、North Carolina、美国、27284
    - Novant Health Cancer Institute - Kernersville
  - Kinston、North Carolina、美国、28501
    - ECU Health Oncology Kinston
  - Matthews、North Carolina、美国、28105
    - Matthews Radiation Oncology Center
  - Matthews、North Carolina、美国、28105
    - Novant Health Cancer Institute - Matthews
  - Mebane、North Carolina、美国、27302
    - Cone Heath Cancer Center at Mebane
  - Mooresville、North Carolina、美国、28117
    - Novant Health Cancer Institute - Mooresville
  - Mount Airy、North Carolina、美国、27030
    - Novant Health Cancer Institute - Mount Airy
  - North Wilkesboro、North Carolina、美国、28659
    - Novant Health Cancer Institute - Wilkesboro
  - Pinehurst、North Carolina、美国、28374
    - FirstHealth of the Carolinas-Moore Regional Hospital
  - Raleigh、North Carolina、美国、27607
    - UNC Rex Healthcare
  - Raleigh、North Carolina、美国、27614
    - UNC Rex Cancer Center of Wakefield
  - Raleigh、North Carolina、美国、27607
    - Duke Women's Cancer Care Raleigh
  - Raleigh、North Carolina、美国、27607
    - Rex Hematology Oncology Associates-Blue Ridge
  - Reidsville、North Carolina、美国、27320
    - Annie Penn Memorial Hospital
  - Salisbury、North Carolina、美国、28144
    - Novant Health Cancer Institute - Rowan
  - Stateville、North Carolina、美国、28625
    - Novant Health Cancer Institute - Statesville
  - Thomasville、North Carolina、美国、27360
    - Novant Health Cancer Institute - Thomasville
  - Winston-Salem、North Carolina、美国、27103
    - Novant Health Forsyth Medical Center
- North Dakota
  - Bismarck、North Dakota、美国、58501
    - Sanford Bismarck Medical Center
  - Fargo、North Dakota、美国、58122
    - Sanford Roger Maris Cancer Center
  - Fargo、North Dakota、美国、58103
    - Essentia Health Cancer Center-South University Clinic
  - Fargo、North Dakota、美国、58122
    - Sanford Broadway Medical Center
  - Fargo、North Dakota、美国、58103
    - Sanford South University Medical Center
  - Fargo、North Dakota、美国、58103
    - Southpointe-Sanford Medical Center Fargo
  - Fargo、North Dakota、美国、58104
    - Sanford Medical Center Fargo
  - Jamestown、North Dakota、美国、58401
    - Essentia Health - Jamestown Clinic
- Ohio
  - Alliance、Ohio、美国、44601
    - Aultman Alliance Community Hospital
  - Beavercreek、Ohio、美国、45431
    - Indu and Raj Soin Medical Center
  - Belpre、Ohio、美国、45714
    - Strecker Cancer Center-Belpre
  - Boardman、Ohio、美国、44512
    - Saint Elizabeth Boardman Hospital
  - Canton、Ohio、美国、44708
    - Cleveland Clinic Mercy Hospital
  - Canton、Ohio、美国、44710
    - Aultman Health Foundation
  - Canton、Ohio、美国、44708
    - Mercy Hematology and Oncology Associates Inc
  - Centerville、Ohio、美国、45459
    - Miami Valley Hospital South
  - Centerville、Ohio、美国、45459
    - Dayton Physicians LLC-Miami Valley South
  - Chillicothe、Ohio、美国、45601
    - Adena Regional Medical Center
  - Cincinnati、Ohio、美国、45219
    - The Christ Hospital
  - Cincinnati、Ohio、美国、45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati、Ohio、美国、45242
    - Bethesda North Hospital
  - Cincinnati、Ohio、美国、45236
    - Oncology Hematology Care Inc-Kenwood
  - Cincinnati、Ohio、美国、45247
    - TriHealth Cancer Institute-Westside
  - Cincinnati、Ohio、美国、45255
    - TriHealth Cancer Institute-Anderson
  - Columbus、Ohio、美国、43214
    - Riverside Methodist Hospital
  - Columbus、Ohio、美国、43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus、Ohio、美国、43219
    - The Mark H Zangmeister Center
  - Columbus、Ohio、美国、43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus、Ohio、美国、43228
    - Doctors Hospital
  - Columbus、Ohio、美国、43213
    - Mount Carmel East Hospital
  - Columbus、Ohio、美国、43215
    - Grant Medical Center
  - Columbus、Ohio、美国、43222
    - Mount Carmel Health Center West
  - Dayton、Ohio、美国、45409
    - Miami Valley Hospital
  - Dayton、Ohio、美国、45415
    - Miami Valley Hospital North
  - Dayton、Ohio、美国、45415
    - Dayton Physician LLC - Englewood
  - Dayton、Ohio、美国、45409
    - Premier Blood and Cancer Center
  - Delaware、Ohio、美国、43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware、Ohio、美国、43015
    - Grady Memorial Hospital
  - Dublin、Ohio、美国、43016
    - Dublin Methodist Hospital
  - Dublin、Ohio、美国、43016
    - Columbus Oncology and Hematology Associates
  - Findlay、Ohio、美国、45840
    - Blanchard Valley Hospital
  - Findlay、Ohio、美国、45840
    - Armes Family Cancer Center
  - Findlay、Ohio、美国、45840
    - Orion Cancer Care
  - Franklin、Ohio、美国、45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Franklin、Ohio、美国、45005
    - Dayton Physicians LLC-Atrium
  - Gahanna、Ohio、美国、43230
    - Central Ohio Breast and Endocrine Surgery
  - Greenville、Ohio、美国、45331
    - Wayne Hospital
  - Greenville、Ohio、美国、45331
    - Dayton Physicians LLC-Wayne
  - Greenville、Ohio、美国、45331
    - Miami Valley Cancer Care and Infusion
  - Grove City、Ohio、美国、43123
    - Mount Carmel Grove City Hospital
  - Kettering、Ohio、美国、45429
    - Kettering Medical Center
  - Kettering、Ohio、美国、45409
    - Greater Dayton Cancer Center
  - Lancaster、Ohio、美国、43130
    - Fairfield Medical Center
  - Lima、Ohio、美国、45801
    - Saint Rita's Medical Center
  - Mansfield、Ohio、美国、44903
    - OhioHealth Mansfield Hospital
  - Marietta、Ohio、美国、45750
    - Marietta Memorial Hospital
  - Marion、Ohio、美国、43302
    - OhioHealth Marion General Hospital
  - Marysville、Ohio、美国、43040
    - Memorial Hospital
  - Mount Vernon、Ohio、美国、43050
    - Knox Community Hospital
  - Newark、Ohio、美国、43055
    - Licking Memorial Hospital
  - Newark、Ohio、美国、43055
    - Newark Radiation Oncology
  - Portsmouth、Ohio、美国、45662
    - Southern Ohio Medical Center
  - Springfield、Ohio、美国、45504
    - Springfield Regional Cancer Center
  - Springfield、Ohio、美国、45504
    - Springfield Regional Medical Center
  - Steubenville、Ohio、美国、43952
    - Trinity's Tony Teramana Cancer Center
  - Sylvania、Ohio、美国、43560
    - ProMedica Flower Hospital
  - Toledo、Ohio、美国、43623
    - Mercy Health - Saint Anne Hospital
  - Toledo、Ohio、美国、43623
    - Toledo Clinic Cancer Centers-Toledo
  - Toledo、Ohio、美国、43608
    - Mercy Health - Saint Vincent Hospital
  - Troy、Ohio、美国、45373
    - Upper Valley Medical Center
  - Troy、Ohio、美国、45373
    - Dayton Physicians LLC - Troy
  - Warren、Ohio、美国、44484
    - Saint Joseph Warren Hospital
  - Westerville、Ohio、美国、43081
    - Saint Ann's Hospital
  - Youngstown、Ohio、美国、44501
    - Saint Elizabeth Youngstown Hospital
  - Zanesville、Ohio、美国、43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Lawton、Oklahoma、美国、73505
    - Cancer Centers of Southwest Oklahoma Research
  - Oklahoma City、Oklahoma、美国、73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City、Oklahoma、美国、73120
    - Mercy Hospital Oklahoma City
  - Oklahoma City、Oklahoma、美国、73109
    - Integris Southwest Medical Center
  - Oklahoma City、Oklahoma、美国、73142
    - Integris Cancer Institute of Oklahoma
- Oregon
  - Baker City、Oregon、美国、97814
    - Saint Alphonsus Cancer Care Center-Baker City
  - Bend、Oregon、美国、97701
    - Saint Charles Health System
  - Clackamas、Oregon、美国、97015
    - Clackamas Radiation Oncology Center
  - Clackamas、Oregon、美国、97015
    - Providence Cancer Institute Clackamas Clinic
  - Coos Bay、Oregon、美国、97420
    - Bay Area Hospital
  - Gresham、Oregon、美国、97030
    - Legacy Mount Hood Medical Center
  - Newberg、Oregon、美国、97132
    - Providence Newberg Medical Center
  - Ontario、Oregon、美国、97914
    - Saint Alphonsus Cancer Care Center-Ontario
  - Oregon City、Oregon、美国、97045
    - Providence Willamette Falls Medical Center
  - Portland、Oregon、美国、97210
    - Legacy Good Samaritan Hospital and Medical Center
  - Portland、Oregon、美国、97213
    - Providence Portland Medical Center
  - Portland、Oregon、美国、97225
    - Providence Saint Vincent Medical Center
  - Redmond、Oregon、美国、97756
    - Saint Charles Health System-Redmond
  - Tualatin、Oregon、美国、97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Allentown、Pennsylvania、美国、18103
    - Lehigh Valley Hospital-Cedar Crest
  - Altoona、Pennsylvania、美国、16601
    - UPMC Altoona
  - Beaver、Pennsylvania、美国、15009
    - UPMC-Heritage Valley Health System Beaver
  - Bethlehem、Pennsylvania、美国、18017
    - Lehigh Valley Hospital - Muhlenberg
  - Broomall、Pennsylvania、美国、19008
    - Crozer-Keystone Regional Cancer Center at Broomall
  - Bryn Mawr、Pennsylvania、美国、19010
    - Bryn Mawr Hospital
  - Butler、Pennsylvania、美国、16001
    - UPMC Hillman Cancer Center at Butler Health System
  - Camp Hill、Pennsylvania、美国、17011
    - UPMC Camp Hill
  - Carlisle、Pennsylvania、美国、17015
    - Carlisle Regional Cancer Center
  - Chadds Ford、Pennsylvania、美国、19317
    - Christiana Care Health System-Concord Health Center
  - Chambersburg、Pennsylvania、美国、17201
    - Chambersburg Hospital
  - Chambersburg、Pennsylvania、美国、17201
    - WellSpan Medical Oncology and Hematology
  - Collegeville、Pennsylvania、美国、19426
    - Main Line Health Center-Collegeville
  - Cranberry Township、Pennsylvania、美国、16066
    - UPMC Hillman Cancer Center - Passavant - Cranberry
  - Danville、Pennsylvania、美国、17822
    - Geisinger Medical Center
  - Drexel Hill、Pennsylvania、美国、19026
    - Delaware County Memorial Hospital
  - East Norriton、Pennsylvania、美国、19401
    - Fox Chase Cancer Center - East Norriton Hospital Outpatient Center
  - East Stroudsburg、Pennsylvania、美国、18301
    - Pocono Medical Center
  - Ephrata、Pennsylvania、美国、17522
    - Ephrata Cancer Center
  - Ephrata、Pennsylvania、美国、17522
    - Ephrata Community Hospital
  - Erie、Pennsylvania、美国、16505
    - UPMC Hillman Cancer Center Erie
  - Exton、Pennsylvania、美国、19341
    - Main Line Health Center-Exton
  - Farrell、Pennsylvania、美国、16121
    - UPMC Cancer Center at UPMC Horizon
  - Gettysburg、Pennsylvania、美国、17325
    - Adams Cancer Center
  - Glen Mills、Pennsylvania、美国、19342
    - Crozer Regional Cancer Center at Brinton Lake
  - Greensburg、Pennsylvania、美国、15601
    - UPMC Cancer Centers - Arnold Palmer Pavilion
  - Greenville、Pennsylvania、美国、16125
    - Oncology Hematology Associates
  - Greenville、Pennsylvania、美国、16125
    - UPMC Hillman Cancer Center in Greenville/UPMC Horizon
  - Hanover、Pennsylvania、美国、17331
    - WellSpan Medical Oncology and Hematology
  - Harrisburg、Pennsylvania、美国、17109
    - UPMC Pinnacle Cancer Center/Community Osteopathic Campus
  - Hazleton、Pennsylvania、美国、18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hazleton、Pennsylvania、美国、18201
    - Lehigh Valley Hospital-Hazleton
  - Hershey、Pennsylvania、美国、17033-0850
    - Penn State Milton S Hershey Medical Center
  - Indiana、Pennsylvania、美国、15701
    - IRMC Cancer Center
  - Johnstown、Pennsylvania、美国、15901
    - UPMC-Johnstown/John P. Murtha Regional Cancer Center
  - Lebanon、Pennsylvania、美国、17042
    - Sechler Family Cancer Center
  - Lewisburg、Pennsylvania、美国、17837
    - Geisinger Medical Oncology-Lewisburg
  - McKeesport、Pennsylvania、美国、15132
    - UPMC Cancer Center at UPMC McKeesport
  - Mechanicsburg、Pennsylvania、美国、17050
    - UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
  - Media、Pennsylvania、美国、19063
    - Riddle Memorial Hospital
  - Monroeville、Pennsylvania、美国、15146
    - UPMC Hillman Cancer Center - Monroeville
  - Moon Township、Pennsylvania、美国、15108
    - UPMC Hillman Cancer Center in Coraopolis
  - Mount Pleasant、Pennsylvania、美国、15666
    - UPMC Hillman Cancer Center - Part of Frick Hospital
  - Natrona Heights、Pennsylvania、美国、15065
    - UPMC Cancer Center-Natrona Heights
  - New Castle、Pennsylvania、美国、16105
    - UPMC Hillman Cancer Center - New Castle
  - North Huntingdon、Pennsylvania、美国、15642
    - Arnold Palmer Cancer Center Medical Oncology Norwin
  - Paoli、Pennsylvania、美国、19301
    - Paoli Memorial Hospital
  - Philadelphia、Pennsylvania、美国、19111
    - Fox Chase Cancer Center
  - Philadelphia、Pennsylvania、美国、19107
    - Thomas Jefferson University Hospital
  - Philadelphia、Pennsylvania、美国、19114
    - Jefferson Torresdale Hospital
  - Philadelphia、Pennsylvania、美国、19104
    - University of Pennsylvania/Abramson Cancer Center
  - Philadelphia、Pennsylvania、美国、19140
    - Temple University Hospital
  - Phoenixville、Pennsylvania、美国、19460
    - Phoenixville Hospital
  - Pittsburgh、Pennsylvania、美国、15213
    - UPMC-Magee Womens Hospital
  - Pittsburgh、Pennsylvania、美国、15232
    - University of Pittsburgh Cancer Institute (UPCI)
  - Pittsburgh、Pennsylvania、美国、15215
    - UPMC-Saint Margaret
  - Pittsburgh、Pennsylvania、美国、15237
    - UPMC-Passavant Hospital
  - Pittsburgh、Pennsylvania、美国、15243
    - UPMC-Saint Clair Hospital Cancer Center
  - Pittsburgh、Pennsylvania、美国、15219
    - UPMC-Mercy Hospital
  - Pottstown、Pennsylvania、美国、19464
    - Pottstown Hospital
  - Pottsville、Pennsylvania、美国、17901
    - Geisinger Cancer Services-Pottsville
  - Sayre、Pennsylvania、美国、18840
    - Guthrie Medical Group PC-Robert Packer Hospital
  - Scranton、Pennsylvania、美国、18510
    - Community Medical Center
  - Seneca、Pennsylvania、美国、16346
    - UPMC Cancer Center at UPMC Northwest
  - Uniontown、Pennsylvania、美国、15401
    - UPMC Cancer Center-Uniontown
  - Upland、Pennsylvania、美国、19013
    - Crozer-Chester Medical Center
  - Washington、Pennsylvania、美国、15301
    - UPMC Cancer Center-Washington
  - West Mifflin、Pennsylvania、美国、15122
    - UPMC West Mifflin-Cancer Center Jefferson
  - West Reading、Pennsylvania、美国、19611
    - Reading Hospital
  - Wilkes-Barre、Pennsylvania、美国、18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Williamsport、Pennsylvania、美国、17701
    - UPMC Susquehanna
  - Williamsport、Pennsylvania、美国、17754
    - Divine Providence Hospital
  - Willow Grove、Pennsylvania、美国、19090
    - Asplundh Cancer Pavilion
  - Wynnewood、Pennsylvania、美国、19096
    - Lankenau Medical Center
  - York、Pennsylvania、美国、17403
    - WellSpan Health-York Cancer Center
  - York、Pennsylvania、美国、17403
    - WellSpan Health-York Hospital
  - York、Pennsylvania、美国、17403
    - Cancer Care Associates of York
  - York、Pennsylvania、美国、17408
    - UPMC Memorial
- Rhode Island
  - Providence、Rhode Island、美国、02903
    - Rhode Island Hospital
  - Providence、Rhode Island、美国、02905
    - Women and Infants Hospital
  - Warwick、Rhode Island、美国、02886
    - Kent Hospital
- South Carolina
  - Beaufort、South Carolina、美国、29902
    - Beaufort Memorial Hospital
  - Bluffton、South Carolina、美国、29910
    - Saint Joseph's/Candler - Bluffton Campus
  - Boiling Springs、South Carolina、美国、29316
    - Prisma Health Cancer Institute - Spartanburg
  - Charleston、South Carolina、美国、29425
    - Medical University of South Carolina
  - Easley、South Carolina、美国、29640
    - Prisma Health Cancer Institute - Easley
  - Florence、South Carolina、美国、29506
    - McLeod Regional Medical Center
  - Gaffney、South Carolina、美国、29341
    - Gibbs Cancer Center-Gaffney
  - Georgetown、South Carolina、美国、29440
    - Tidelands Georgetown Memorial Hospital
  - Greenville、South Carolina、美国、29605
    - Prisma Health Cancer Institute - Faris
  - Greenville、South Carolina、美国、29607
    - Saint Francis Cancer Center
  - Greenville、South Carolina、美国、29615
    - Prisma Health Cancer Institute - Eastside
  - Greenville、South Carolina、美国、29605
    - Prisma Health Cancer Institute - Butternut
  - Greenville、South Carolina、美国、29601
    - Saint Francis Hospital
  - Greenville、South Carolina、美国、29605
    - Prisma Health Greenville Memorial Hospital
  - Greer、South Carolina、美国、29650
    - Prisma Health Cancer Institute - Greer
  - Greer、South Carolina、美国、29651
    - Gibbs Cancer Center-Pelham
  - Hilton Head Island、South Carolina、美国、29926-3827
    - South Carolina Cancer Specialists PC
  - Seneca、South Carolina、美国、29672
    - Prisma Health Cancer Institute - Seneca
  - Spartanburg、South Carolina、美国、29303
    - Spartanburg Medical Center
  - Union、South Carolina、美国、29379
    - MGC Hematology Oncology-Union
  - West Columbia、South Carolina、美国、29169
    - Lexington Medical Center
- South Dakota
  - Aberdeen、South Dakota、美国、57401
    - Avera Cancer Institute-Aberdeen
  - Sioux Falls、South Dakota、美国、57105
    - Avera Cancer Institute
  - Sioux Falls、South Dakota、美国、57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls、South Dakota、美国、57104
    - Sanford Cancer Center Oncology Clinic
  - Yankton、South Dakota、美国、57078
    - Avera Cancer Institute at Yankton
- Tennessee
  - Alcoa、Tennessee、美国、37701
    - University Cancer Specialists - Alcoa
  - Collierville、Tennessee、美国、38017
    - Baptist Memorial Hospital and Cancer Center-Collierville
  - Cookeville、Tennessee、美国、38501
    - Cookeville Regional Medical Center
  - Franklin、Tennessee、美国、37067
    - Vanderbilt-Ingram Cancer Center Cool Springs
  - Kingsport、Tennessee、美国、37660
    - Ballad Health Cancer Care - Kingsport
  - Knoxville、Tennessee、美国、37920
    - University of Tennessee - Knoxville
  - Memphis、Tennessee、美国、38120
    - Baptist Memorial Hospital and Cancer Center-Memphis
  - Nashville、Tennessee、美国、37232
    - Vanderbilt University/Ingram Cancer Center
  - Nashville、Tennessee、美国、37204
    - Vanderbilt Breast Center at One Hundred Oaks
- Texas
  - Amarillo、Texas、美国、79106
    - The Don and Sybil Harrington Cancer Center
  - Baytown、Texas、美国、77521
    - Houston Methodist San Jacinto Hospital
  - Bryan、Texas、美国、77802
    - Saint Joseph Regional Cancer Center
  - Conroe、Texas、美国、77384
    - MD Anderson in The Woodlands
  - Dallas、Texas、美国、75235
    - Parkland Memorial Hospital
  - Dallas、Texas、美国、75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - Dallas、Texas、美国、75237
    - UT Southwestern Simmons Cancer Center - RedBird
  - Fort Worth、Texas、美国、76104
    - UT Southwestern/Simmons Cancer Center-Fort Worth
  - Galveston、Texas、美国、77555-0565
    - University of Texas Medical Branch
  - Houston、Texas、美国、77030
    - M D Anderson Cancer Center
  - Houston、Texas、美国、77026-1967
    - Lyndon Baines Johnson General Hospital
  - Houston、Texas、美国、77030
    - Houston Methodist Hospital
  - Houston、Texas、美国、77030
    - Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
  - Houston、Texas、美国、77070
    - Methodist Willowbrook Hospital
  - Houston、Texas、美国、77030
    - Ben Taub General Hospital
  - Houston、Texas、美国、77094
    - Houston Methodist West Hospital
  - Houston、Texas、美国、77079
    - MD Anderson West Houston
  - Laredo、Texas、美国、78041
    - Doctor's Hospital of Laredo
  - League City、Texas、美国、77573
    - MD Anderson League City
  - Lubbock、Texas、美国、79415
    - UMC Cancer Center / UMC Health System
  - Nassau Bay、Texas、美国、77058
    - Houston Methodist Saint John Hospital
  - Richardson、Texas、美国、75080
    - UT Southwestern Clinical Center at Richardson/Plano
  - Sugar Land、Texas、美国、77478
    - MD Anderson in Sugar Land
  - Sugar Land、Texas、美国、77479
    - Houston Methodist Sugar Land Hospital
  - The Woodlands、Texas、美国、77385
    - Houston Methodist The Woodlands Hospital
- Virginia
  - Bristol、Virginia、美国、24201
    - Wellmont Medical Associates-Bristol
  - Burke、Virginia、美国、22015
    - Kaiser Permanente-Burke Medical Center
  - Chesapeake、Virginia、美国、23320
    - Cancer Specialists of Tidewater Limited
  - Fairfax、Virginia、美国、22031
    - Inova Schar Cancer Institute
  - Fairfax、Virginia、美国、22033
    - Inova Fair Oaks Hospital
  - Gloucester、Virginia、美国、23061
    - Peninsula Cancer Institute-Gloucester
  - Lynchburg、Virginia、美国、24501
    - Centra Alan B Pearson Regional Cancer Center
  - McLean、Virginia、美国、22102
    - Kaiser Permanente Tysons Corner Medical Center
  - Mechanicsville、Virginia、美国、23116
    - Bon Secours Memorial Regional Medical Center
  - Midlothian、Virginia、美国、23114
    - Bon Secours Saint Francis Medical Center
  - Midlothian、Virginia、美国、23113
    - Bon Secours Westchester Emergency Center
  - Newport News、Virginia、美国、23601
    - Peninsula Cancer Institute-Newport News
  - Norfolk、Virginia、美国、23505
    - Bon Secours DePaul Medical Center
  - Portsmouth、Virginia、美国、23707
    - Bon Secours Maryview Medical Center
  - Richmond、Virginia、美国、23235
    - VCU Massey Cancer Center at Stony Point
  - Richmond、Virginia、美国、23298
    - Virginia Commonwealth University/Massey Cancer Center
  - Richmond、Virginia、美国、23229
    - Virginia Cancer Institute
  - Richmond、Virginia、美国、23226
    - Bon Secours Saint Mary's Hospital
  - Richmond、Virginia、美国、23230
    - Bon Secours Cancer Institute at Reynolds Crossing
  - South Hill、Virginia、美国、23970
    - VCU Community Memorial Health Center
  - Suffolk、Virginia、美国、23435
    - Cancer Specialists of Tidewater-Suffolk
  - Suffolk、Virginia、美国、23435
    - Bon Secours Health Center at Harbour View
  - Virginia Beach、Virginia、美国、23454
    - Peninsula Cancer Institute-Cancer Specialists of Tidewater
  - Williamsburg、Virginia、美国、23185
    - Peninsula Cancer Institute-Williamsburg
  - Woodbridge、Virginia、美国、22192
    - Kaiser Permanente-Caton Hill Medical Center
- Washington
  - Aberdeen、Washington、美国、98520
    - Providence Regional Cancer System-Aberdeen
  - Auburn、Washington、美国、98001
    - MultiCare Auburn Medical Center
  - Bellevue、Washington、美国、98004
    - Overlake Medical Center
  - Bellingham、Washington、美国、98225
    - PeaceHealth Saint Joseph Medical Center
  - Bremerton、Washington、美国、98310
    - Harrison HealthPartners Hematology and Oncology-Bremerton
  - Burien、Washington、美国、98166
    - Highline Medical Center-Main Campus
  - Centralia、Washington、美国、98531
    - Providence Regional Cancer System-Centralia
  - Edmonds、Washington、美国、98026
    - Swedish Cancer Institute-Edmonds
  - Enumclaw、Washington、美国、98022
    - Saint Elizabeth Hospital
  - Everett、Washington、美国、98201
    - Providence Regional Cancer Partnership
  - Federal Way、Washington、美国、98003
    - Saint Francis Hospital
  - Gig Harbor、Washington、美国、98335
    - MultiCare Gig Harbor Medical Park
  - Issaquah、Washington、美国、98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick、Washington、美国、99336
    - Kadlec Clinic Hematology and Oncology
  - Lacey、Washington、美国、98503
    - Providence Regional Cancer System-Lacey
  - Lakewood、Washington、美国、98499
    - Saint Clare Hospital
  - Longview、Washington、美国、98632
    - PeaceHealth Saint John Medical Center
  - Port Townsend、Washington、美国、98368
    - Jefferson Healthcare
  - Poulsbo、Washington、美国、98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Puyallup、Washington、美国、98372
    - MultiCare Good Samaritan Hospital
  - Renton、Washington、美国、98055
    - Valley Medical Center
  - Seattle、Washington、美国、98107
    - Swedish Medical Center-Ballard Campus
  - Seattle、Washington、美国、98122
    - Swedish Medical Center-First Hill
  - Seattle、Washington、美国、98104
    - Pacific Gynecology Specialists
  - Seattle、Washington、美国、98122-5711
    - Swedish Medical Center-Cherry Hill
  - Sedro-Woolley、Washington、美国、98284
    - PeaceHealth United General Medical Center
  - Shelton、Washington、美国、98584
    - Providence Regional Cancer System-Shelton
  - Silverdale、Washington、美国、98383
    - Saint Michael Cancer Center
  - Spokane、Washington、美国、99204
    - MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
  - Spokane、Washington、美国、99218
    - MultiCare Deaconess Cancer and Blood Specialty Center - North
  - Tacoma、Washington、美国、98405
    - Northwest Medical Specialties PLLC
  - Tacoma、Washington、美国、98405
    - MultiCare Tacoma General Hospital
  - Tacoma、Washington、美国、98405
    - Franciscan Research Center-Northwest Medical Plaza
  - Vancouver、Washington、美国、98686
    - Legacy Salmon Creek Hospital
  - Vancouver、Washington、美国、98664
    - PeaceHealth Southwest Medical Center
  - Vancouver、Washington、美国、98684
    - Legacy Cancer Institute Medical Oncology and Day Treatment
  - Walla Walla、Washington、美国、99362
    - Providence Saint Mary Regional Cancer Center
  - Yakima、Washington、美国、98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
  - Yelm、Washington、美国、98597
    - Providence Regional Cancer System-Yelm
- West Virginia
  - Charleston、West Virginia、美国、25304
    - West Virginia University Charleston Division
  - Huntington、West Virginia、美国、25701
    - Edwards Comprehensive Cancer Center
- Wisconsin
  - Antigo、Wisconsin、美国、54409
    - Langlade Hospital and Cancer Center
  - Appleton、Wisconsin、美国、54911
    - ThedaCare Regional Cancer Center
  - Appleton、Wisconsin、美国、54915
    - Ascension Saint Elizabeth Hospital
  - Ashland、Wisconsin、美国、54806
    - Duluth Clinic Ashland
  - Ashland、Wisconsin、美国、54806
    - Northwest Wisconsin Cancer Center
  - Brookfield、Wisconsin、美国、53045
    - Ascension Southeast Wisconsin Hospital - Elmbrook Campus
  - Burlington、Wisconsin、美国、53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Chilton、Wisconsin、美国、53014
    - Ascension Calumet Hospital
  - Cudahy、Wisconsin、美国、53110
    - Aurora Saint Luke's South Shore
  - Eau Claire、Wisconsin、美国、54701
    - Marshfield Medical Center-EC Cancer Center
  - Eau Claire、Wisconsin、美国、54701
    - HSHS Sacred Heart Hospital
  - Franklin、Wisconsin、美国、53132
    - Ascension Saint Francis - Reiman Cancer Center
  - Franklin、Wisconsin、美国、53132
    - Ascension Southeast Wisconsin Hospital - Franklin
  - Germantown、Wisconsin、美国、53022
    - Aurora Health Care Germantown Health Center
  - Grafton、Wisconsin、美国、53024
    - Aurora Cancer Care-Grafton
  - Green Bay、Wisconsin、美国、54311
    - Aurora BayCare Medical Center
  - Green Bay、Wisconsin、美国、54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay、Wisconsin、美国、54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Janesville、Wisconsin、美国、53548
    - Mercyhealth Hospital and Cancer Center - Janesville
  - Johnson Creek、Wisconsin、美国、53038
    - University of Wisconsin Carbone Cancer Center - Johnson Creek
  - Kenosha、Wisconsin、美国、53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse、Wisconsin、美国、54601
    - Gundersen Lutheran Medical Center
  - Madison、Wisconsin、美国、53792
    - University of Wisconsin Carbone Cancer Center - University Hospital
  - Marinette、Wisconsin、美国、54143
    - Aurora Bay Area Medical Group-Marinette
  - Marshfield、Wisconsin、美国、54449
    - Marshfield Medical Center-Marshfield
  - Medford、Wisconsin、美国、54451
    - Aspirus Medford Hospital
  - Menomonee Falls、Wisconsin、美国、53051
    - Froedtert Menomonee Falls Hospital
  - Mequon、Wisconsin、美国、53097
    - Ascension Columbia Saint Mary's Hospital Ozaukee
  - Milwaukee、Wisconsin、美国、53226
    - Medical College of Wisconsin
  - Milwaukee、Wisconsin、美国、53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee、Wisconsin、美国、53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee、Wisconsin、美国、53233
    - Aurora Sinai Medical Center
  - Milwaukee、Wisconsin、美国、53210
    - Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
  - Milwaukee、Wisconsin、美国、53211
    - Ascension Columbia Saint Mary's Hospital - Milwaukee
  - Milwaukee、Wisconsin、美国、53215
    - Ascension Saint Francis Hospital
  - Minocqua、Wisconsin、美国、54548
    - Marshfield Clinic-Minocqua Center
  - Mukwonago、Wisconsin、美国、53149
    - ProHealth D N Greenwald Center
  - Neenah、Wisconsin、美国、54956
    - ThedaCare Regional Medical Center - Neenah
  - New Richmond、Wisconsin、美国、54017
    - Cancer Center of Western Wisconsin
  - Oak Creek、Wisconsin、美国、53154
    - Drexel Town Square Health Center
  - Oconomowoc、Wisconsin、美国、53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oconto Falls、Wisconsin、美国、54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Oshkosh、Wisconsin、美国、54904
    - Ascension Mercy Hospital
  - Oshkosh、Wisconsin、美国、54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine、Wisconsin、美国、53406
    - Aurora Cancer Care-Racine
  - Racine、Wisconsin、美国、53405
    - Ascension All Saints Hospital
  - Rhinelander、Wisconsin、美国、54501
    - Ascension Saint Mary's Hospital
  - Rice Lake、Wisconsin、美国、54868
    - Marshfield Medical Center-Rice Lake
  - Sheboygan、Wisconsin、美国、53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Stevens Point、Wisconsin、美国、54481
    - Ascension Saint Michael's Hospital
  - Stevens Point、Wisconsin、美国、54482
    - Marshfield Medical Center-River Region at Stevens Point
  - Sturgeon Bay、Wisconsin、美国、54235-1495
    - Saint Vincent Hospital Cancer Center at Sturgeon Bay
  - Summit、Wisconsin、美国、53066
    - Aurora Medical Center in Summit
  - Two Rivers、Wisconsin、美国、54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha、Wisconsin、美国、53188
    - UW Cancer Center at ProHealth Care
  - Waukesha、Wisconsin、美国、53188
    - ProHealth Waukesha Memorial Hospital
  - Waupaca、Wisconsin、美国、54981
    - ThedaCare Cancer Care - Waupaca
  - Wausau、Wisconsin、美国、54401
    - Aspirus Regional Cancer Center
  - Wauwatosa、Wisconsin、美国、53226
    - Aurora Cancer Care-Milwaukee West
  - Wauwatosa、Wisconsin、美国、53226
    - Ascension Medical Group Southeast Wisconsin - Mayfair Road
  - West Allis、Wisconsin、美国、53227
    - Aurora West Allis Medical Center
  - West Bend、Wisconsin、美国、53095
    - Froedtert West Bend Hospital/Kraemer Cancer Center
  - Weston、Wisconsin、美国、54476
    - Marshfield Medical Center - Weston
  - Wisconsin Rapids、Wisconsin、美国、54494
    - Aspirus Cancer Care - Wisconsin Rapids
- Wyoming
  - Cheyenne、Wyoming、美国、82001
    - Cheyenne Regional Medical Center-West
  - Cody、Wyoming、美国、82414
    - Billings Clinic-Cody
  - Sheridan、Wyoming、美国、82801
    - Welch Cancer Center

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年及以上 (成人、年长者)

接受健康志愿者

不

描述

纳入标准：

HER2 阳性状态将基于治疗前活检材料，根据当前美国临床肿瘤学会 (ASCO) 美国病理学家学会定义为免疫组织化学 (IHC) 评分 3+ 和/或原位杂交 (ISH) 阳性 ( CAP）指南。不需要中央测试
* ASCO/CAP 指南定义的已知激素受体 (HR) 状态（基于治疗前活检材料）。激素受体阳性状态可以通过已知阳性雌激素受体 (ER) 或已知阳性孕激素受体 (PR) 状态来确定；激素受体阴性状态必须由已知的阴性 ER 和已知的阴性 PR 来确定
临床分期为 T1-4、就诊时患有 N0-3 疾病且术后残留侵袭性疾病的患者符合上述定义。（注意：患有 T1a/bN0 肿瘤的患者在初始乳腺癌诊断时不符合资格）
根据手术病理报告，乳腺和/或淋巴结中残留 HR 阴性、HER2 阳性 (+) 疾病的患者符合条件；但是，根据手术病理报告，HR+ HER2+ 癌症患者必须有淋巴结阳性残留病灶，才有资格参加研究。对于这些患者，乳房中存在残留浸润性疾病不是强制性的
弱 ER 阳性 (1-10%) 乳腺癌患者（基于治疗前核心活检）符合条件，即使他们根据手术病理报告患有淋巴结阴性疾病
残留疾病组织（乳腺和/或淋巴结）不需要是 HER2 阳性，因为 NCI-2020-03770 (A011801) 的资格是基于初始乳腺癌诊断时的 HER2 阳性状态
* 注：术前治疗后淋巴结中微转移的存在算作残留病灶，而孤立的肿瘤细胞的存在不算
如果两个病灶都被确认为 HER2 阳性，并且至少一个病灶符合上述标准，则同时患有双侧浸润性疾病的患者符合条件。多灶性疾病是允许的，只要最大的活检乳腺肿瘤是 HER2 阳性
患者必须接受过以下方案之一的新辅助化疗：多西紫杉醇/曲妥珠单抗/帕妥珠单抗 (THP)、紫杉醇/甲氨蝶呤/顺铂 (TMP)、多柔比星/环磷酰胺/紫杉醇/曲妥珠单抗/帕妥珠单抗 (AC-TH(P))；多西紫杉醇/卡铂/曲妥珠单抗/帕妥珠单抗 (TCH(P))；氟尿嘧啶/多柔比星/环磷酰胺-多西紫杉醇/曲妥珠单抗/帕妥珠单抗 (FAC-TH(P))，或氟尿嘧啶/表柔比星/环磷酰胺-多西紫杉醇/曲妥珠单抗/帕妥珠单抗 (FEC-TH(P))。注意：除了 TCHP，其中 T 是多西紫杉醇，多西紫杉醇或紫杉醇治疗是可以接受的
不允许在新辅助治疗中事先接受 T-DM1。
- 既往治疗必须包括 >= 6 个周期的化疗和 HER2 靶向治疗，总持续时间 >= 12 周，包括至少 9 周的术前紫杉烷和曲妥珠单抗联合或不联合帕妥珠单抗（或食品和药物管理局 [FDA ]-批准的生物仿制药）。接受至少 9 周术前紫杉烷、帕妥珠单抗和 margetuximab 治疗的患者如果在入组前接受了 >= 6 个周期的全身治疗，也符合条件。注意：完成计划的每周 12 剂紫杉醇中的至少 9 剂，或完成计划的 4 剂多西紫杉醇中的 3 剂，但由于毒性而过早停药的患者符合条件。接受剂量密集化疗方案的患者也符合条件。允许事先使用白蛋白结合型紫杉醇 (Abraxane) 代替紫杉醇或多西紫杉醇。也允许事先使用皮下曲妥珠单抗 (Hylecta) 和皮下曲妥珠单抗和帕妥珠单抗 (Phesgo)。
- 接受包括实验性 HER2 靶向治疗在内的新辅助全身治疗的患者可能符合条件，只要研究药物不是 HER2 靶向抗体药物偶联物（例如 T-DM1、DS-8201a [trastuzumab deruxtecan]) 或 HER2 靶向酪氨酸激酶抑制剂 (TKI)（例如图卡替尼、拉帕替尼、来那替尼）。
患者可能在辅助治疗中接受了 =< 1 个周期的 T-DM1。注意：这些患者将随机接受另外 14 个周期的 T-DM1 和 tucatinib/安慰剂作为耐受。最近的 T-DM1 周期应该在注册前 =< 5 周
* 注：患者需同时满足以下两个标准才有资格参加本研究
- 最后一次确定性治疗的完成日期之间的间隔不超过 12 周（例如术后化疗或放疗，或者如果两者都没有，乳房手术日期）和登记日期。接受研究治疗时允许同步放疗
- 患者必须在最近一次明确的乳腺癌手术（不包括重建手术）之日起 =< 180 天内登记参加研究
除非参与 EA1181（CompassHER2 病理完全缓解 [pCR]）或 BIG DECRESCENDO 试验（在研究设计、药物和资格方面与 CompassHER2 pCR 非常相似），否则所有全身化疗都应在术前完成。然而，接受 4 个周期的新辅助 THP 关闭研究的患者可以在术后接受进一步的 2-4 个周期的化疗以满足 A011801 的资格。参加 EA1181 或 MA41 并在降阶梯试验方案后立即进行手术的患者必须接受术后化疗，以在入组 A011801 之前完成总计 >= 6 个周期的全身治疗，如上所述（例如 4 个周期预手术和术后 2 个周期）。规定的术后化疗方案由治疗肿瘤科医生决定（即 2-4 周期 AC 或 THP，其他）。允许所有研究参与者在术前或术后继续使用曲妥珠单抗 + 帕妥珠单抗 (HP) 作为维持治疗（同时等待手术日期或官方病理报告）
除了脱发和周围神经病变 =< 1 级外，与先前全身治疗相关的毒性应该已经解决或处于基线水平
充分切除：手术切除乳房和淋巴结中所有临床明显的疾病，如下所示：
- 乳房手术：全乳房切除术，切除边缘无大体残留病灶，或切除边缘组织学阴性的保乳手术
- 对于接受保乳手术的患者，切除标本的边缘必须在组织学上无浸润性肿瘤和导管原位癌 (DCIS)，由当地病理学家确定。如果病理检查显示切除线上有肿瘤，则可以进行额外的手术以获得清晰的边缘。如果在重新切除后肿瘤仍然存在于切除边缘，则患者必须接受全乳切除术才有资格。经典小叶原位癌 (LCIS) 切缘阳性的患者符合条件，无需额外切除
- 淋巴结手术 ** 腋窝需要通过前哨淋巴结活检或腋窝淋巴结清扫术进行评估。如果患者进行了前哨淋巴结活检并且前哨淋巴结呈阴性，则无需进一步的腋窝治疗。如果患者在残留乳腺疾病的情况下有孤立的肿瘤细胞 (ITC)，则至少需要以下一项：腋窝淋巴结清扫术 (ALND) 或计划的淋巴结照射。如果患者有微转移或大转移淋巴结病，则需要进行 ALND 和计划的淋巴结照射。请注意，不允许联合注册 Alliance A011202
东部合作肿瘤组 (ECOG) 表现状态 0-1
中性粒细胞绝对计数 (ANC) >= 1,000/mm^3
血红蛋白 >= 8 g/dL（注意：不允许输注浓集红细胞 [PRBC] 以达到资格）
血小板计数 >= 100,000/mm^3
肌酐 =< 1.5 x 正常值上限 (ULN)
总胆红素 =< 1.0 x 正常上限 (ULN) 或吉尔伯特综合征患者机构正常范围内的直接胆红素
天冬氨酸转氨酶 (AST)/丙氨酸转氨酶 (ALT) =< 2.5 x 正常上限 (ULN)
在接受新辅助化疗后筛查左心室射血分数 (LVEF) >= 50% 的超声心动图 (ECHO) 或多门采集 (MUGA)，并且 LVEF 与化疗前 LVEF 相比没有下降超过 15% 的绝对百分比。或者，如果未评估化疗前 LVEF，则在完成新辅助化疗后筛查 LVEF 必须 >= 55%。注意：LVEF 评估可能会在初始筛选评估后最多 3 周内重复一次，以评估资格

排除标准：

注册前 28 天内未使用任何抗癌研究药物进行辅助治疗
没有怀孕也没有哺乳，因为这项研究涉及一种已知具有遗传毒性、诱变和致畸作用的药物。因此，仅对于有生育能力的女性，需要在注册前 =< 7 天进行血清妊娠试验阴性
患有已知活动性和/或未经治疗的乙型肝炎或丙型肝炎或慢性肝病的患者不符合资格。如果满足其他资格参数，诊断为乙型或丙型肝炎且已接受治疗和清除且肝功能正常的患者有资格参加研究
IV 期（转移性）乳腺癌
登记后 3 年内有任何既往（同侧或对侧）浸润性乳腺癌病史
根据手术病理报告，ER+ HER2+ 淋巴结阴性的残留浸润性疾病患者
术前治疗和手术后疾病复发的证据
建议放疗用于乳腺癌治疗但由于医学原因（例如，结缔组织疾病或既往同侧乳房放疗）而禁忌放疗的患者
下列累积剂量蒽环类药物的暴露史：多柔比星 > 240 mg/m^2；表柔比星或脂质体阿霉素盐酸盐 (Myocet) > 480 mg/m^2。对于其他蒽环类药物，暴露相当于多柔比星 > 240 mg/m^2
由以下任何一项定义的心肺功能障碍：
- 国家癌症研究所 (NCI) CTCAE 版本 (v) 5.0 级的历史 >= 3 症状性充血性心力衰竭 (CHF) 或纽约心脏协会 (NYHA) 标准等级 >= II
- 需要抗心绞痛药物治疗的心绞痛、药物不能有效控制的严重心律失常、严重的传导异常或有临床意义的瓣膜病
- 高危不受控制的心律失常：即静息时心率 > 100/分钟的房性心动过速、显着的室性心律失常（室性心动过速）或更高级别的房室传导阻滞 (AV) 阻滞（二度 AV 传导阻滞 2 型 [Mobitz 2 ] 或三度 AV 阻滞）
- 在接受术前治疗期间或之后出现与左心室功能不全、心律失常或心肌缺血相关的显着症状（等级 >= 2）
- 左心室射血分数 (LVEF) 降低至 < 40% 的既往曲妥珠单抗治疗史（例如，在术前治疗期间）
- 未控制的高血压（收缩压 > 180 mmHg 和/或舒张压 > 100 mmHg）
当前严重的、不受控制的全身性疾病
注册前 28 天内进行过与乳腺癌或重大外伤无关的大手术，或预计在研究治疗过程中需要大手术
不耐受史，包括 3 至 4 级输液反应或对曲妥珠单抗或鼠类蛋白质或产品的任何成分过敏
超过 1 级的任何病因的周围神经病变
研究者评估为不能或不愿遵守方案的要求
禁止在注册前 2 周内使用强效 CYP3A4 或 CYP2C8 抑制剂，或在注册前 5 天内使用强效 CYP3A4 或 CYP2C8 诱导剂。
- 请注意，在注册前两周和研究治疗期间应避免使用敏感的 CYP3A 底物。此外，在停止 tucatinib 治疗后 5 天内，禁止将 CYP3A4 或 CYP2C8 诱导剂作为伴随药物。需要使用已知为 CYP3A4 敏感底物且治疗窗狭窄的药物的患者应排除在外。

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

主要用途：治疗
分配：随机化
介入模型：并行分配
屏蔽：双倍的

手臂数量

武器和干预

参与者组/臂	干预/治疗
有源比较器：Arm I (trastuzumab emtansine, placebo) Patients receive T-DM1 IV over 30-90 minutes on day 1 and placebo PO BID on days 1-21. Treatment repeats every 21 days for up to 14 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo echocardiography/multigated acquisition (MUGA) scan and blood sample collection throughout the study. Patients undergo echocardiography/multigated acquisition (MUGA) scan and blood sample collection throughout the study.	其他：生活质量评估辅助研究其他：问卷管理辅助研究生物：曲妥珠单抗 Emtansine 鉴于IV 药品：安慰剂给药给定采购订单
实验性的：Arm II (trastuzumab emtansine, tucatinib) Patients receive T-DM1 IV over 30-90 minutes on day 1 and tucatinib PO BID on days 1-21. Treatment repeats every 21 days for up to 14 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo echocardiography/multigated acquisition (MUGA) scan and blood sample collection throughout the study.	其他：生活质量评估辅助研究其他：问卷管理辅助研究生物：曲妥珠单抗 Emtansine 鉴于IV 药品：图卡替尼给定采购订单

参与者组/臂

干预/治疗

有源比较器：Arm I (trastuzumab emtansine, placebo)

Patients receive T-DM1 IV over 30-90 minutes on day 1 and placebo PO BID on days 1-21. Treatment repeats every 21 days for up to 14 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo echocardiography/multigated acquisition (MUGA) scan and blood sample collection throughout the study. Patients undergo echocardiography/multigated acquisition (MUGA) scan and blood sample collection throughout the study.

其他：生活质量评估

辅助研究

其他：问卷管理

辅助研究

生物：曲妥珠单抗 Emtansine

鉴于IV

药品：安慰剂给药

给定采购订单

实验性的：Arm II (trastuzumab emtansine, tucatinib)

Patients receive T-DM1 IV over 30-90 minutes on day 1 and tucatinib PO BID on days 1-21. Treatment repeats every 21 days for up to 14 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo echocardiography/multigated acquisition (MUGA) scan and blood sample collection throughout the study.

其他：生活质量评估

辅助研究

其他：问卷管理

辅助研究

生物：曲妥珠单抗 Emtansine

鉴于IV

药品：图卡替尼

给定采购订单

研究衡量的是什么？

主要结果指标

结果测量	措施说明	大体时间
改良的无创生存期 (iDFS) 大体时间：从随机化到以下事件之一：浸润性局部、区域或远处复发，浸润性对侧乳腺癌或任何原因死亡，评估长达 10 年	Kaplan-Meier 方法将用于估计生存曲线，分层对数秩检验将用于比较两组的无侵袭性疾病生存 (iDFS)。分层 Cox 模型将用于估计风险比。如果治疗组之间的基线变量似乎存在临床上显着的不平衡，则主要终点的二次分析将使用分层 Cox 模型来比较治疗效果，其中包括被视为治疗组之间不平衡的变量作为调整变量。随机化分层变量将是模型中的分层变量。	从随机化到以下事件之一：浸润性局部、区域或远处复发，浸润性对侧乳腺癌或任何原因死亡，评估长达 10 年

次要结果测量

结果测量	措施说明	大体时间
未修改的侵入性无病生存 (iDFS) 大体时间：长达 10 年	将被定义为从随机化到发生以下事件之一的时间：浸润性局部、区域或远处复发，浸润性对侧乳腺癌继发性原发性浸润性癌症（皮肤基底细胞癌或鳞状细胞癌除外，或宫颈原位癌除外） )，或因任何原因死亡，评估长达 10 年。 Kaplan-Meier 方法将用于估计生存曲线，分层对数秩检验将用于比较两组的 iDFS。分层 Cox 模型将用于估计风险比。	长达 10 年
无乳腺癌生存期大体时间：从随机化到浸润性局部、区域或远处复发，或浸润性对侧乳腺癌，评估长达 10 年	将使用 Kaplan-Meier 曲线进行总结，并使用分层对数秩检验和分层 Cox 模型在各臂之间进行比较。如果治疗组之间的基线特征存在临床显着不平衡，将使用分层 Cox 模型进行第二次分析，并将不平衡的变量添加为调整变量。	从随机化到浸润性局部、区域或远处复发，或浸润性对侧乳腺癌，评估长达 10 年
无脑转移生存期大体时间：从随机分组到记录转移性癌症（包括脑实质和脊髓转移以及软脑膜癌病）对中枢神经系统的影响，评估长达 10 年	将使用 Kaplan-Meier 曲线进行总结，并使用分层对数秩检验和分层 Cox 模型在各臂之间进行比较。如果治疗组之间的基线特征存在临床显着不平衡，将使用分层 Cox 模型进行第二次分析，并将不平衡的变量添加为调整变量。	从随机分组到记录转移性癌症（包括脑实质和脊髓转移以及软脑膜癌病）对中枢神经系统的影响，评估长达 10 年
总生存期大体时间：从随机分组到全因死亡，评估长达 10 年	将使用 Kaplan-Meier 曲线进行总结，并使用分层对数秩检验和分层 Cox 模型在各臂之间进行比较。如果治疗组之间的基线特征存在临床显着不平衡，将使用分层 Cox 模型进行第二次分析，并将不平衡的变量添加为调整变量。	从随机分组到全因死亡，评估长达 10 年
脑转移的发生率大体时间：长达 10 年	脑转移事件是转移性癌症（包括脑实质和脊髓转移以及软脑膜转移癌）累及中枢神经系统的证据。脑转移的累积发生率将被确定为粗累积发生率以及竞争事件为死亡的竞争风险的发生率。	长达 10 年
Distant recurrence-free survival 大体时间：From randomization to the first incidence of distant recurrence, assessed up to 10 years	Will be summarized with Kaplan-Meier curves and compared between the arms using a stratified log-rank test and stratified Cox model. If there are clinically significant imbalances in baseline characteristics between the treatment arms, a second analysis will be done using a stratified Cox model with the variables that are imbalanced added as adjusting variables.	From randomization to the first incidence of distant recurrence, assessed up to 10 years
Disease-free survival 大体时间：From randomization to the first incidence of invasive local, regional, or distant recurrence, second primary non-breast cancer event, or contralateral or ipsilateral ductal carcinoma in situ, assessed up to 10 years.	Will be summarized with Kaplan-Meier curves and compared between the arms using a stratified log-rank test and stratified Cox model. If there are clinically significant imbalances in baseline characteristics between the treatment arms, a second analysis will be done using a stratified Cox model with the variables that are imbalance added as adjusting variables.	From randomization to the first incidence of invasive local, regional, or distant recurrence, second primary non-breast cancer event, or contralateral or ipsilateral ductal carcinoma in situ, assessed up to 10 years.

其他结果措施

结果测量	措施说明	大体时间
Quality of life 大体时间：Up to day 1 of cycle 14 (each cycle is 21 days)	Will be assessed by the FACT-B Trial Outcome Index questionnaire. The mixed model will compare the mean change from baseline at cycle 14 day 1 between arms. If the two-sided 95% confidence interval excludes a difference of 5 favoring the T-DM1 + placebo arm, then non-inferiority will be concluded at this time point.	Up to day 1 of cycle 14 (each cycle is 21 days)

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Alliance for Clinical Trials in Oncology

合作者

National Cancer Institute (NCI)

Seagen Inc.

调查人员

学习椅：Ciara C. O'Sullivan, MB, BCh, BAO、Mayo Clinic

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负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

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研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2021年3月2日

初级完成 (估计的)

2028年1月31日

研究完成 (估计的)

2035年5月31日

研究注册日期

首次提交

2020年6月30日

首先提交符合 QC 标准的

2020年6月30日

首次发布 (实际的)

2020年7月7日

研究记录更新

最后更新发布 (实际的)

2026年6月15日

上次提交的符合 QC 标准的更新

2026年6月11日

最后验证

2025年10月1日

T-DM1 和 Tucatinib 与单独使用 T-DM1 在预防高危 HER2 阳性乳腺癌患者复发方面的比较，CompassHER2 RD 试验

CompassHER2 试验（综合使用病理反应评估优化 HER2 阳性乳腺癌的治疗）CompassHER2 残留病灶 (RD)，T-DM1 与 T-DM1 和 Tucatinib 相比的双盲 III 期随机试验

研究概览

地位

条件

干预/治疗

详细说明

研究类型

注册 (实际的)

阶段

联系人和位置

学习地点

参与标准

资格标准

适合学习的年龄

接受健康志愿者

描述

学习计划

研究是如何设计的？

设计细节

手臂数量

武器和干预

参与者组/臂

干预/治疗

研究衡量的是什么？

主要结果指标

结果测量

措施说明

大体时间

次要结果测量

结果测量

措施说明

大体时间

其他结果措施

结果测量

措施说明

大体时间

合作者和调查者

赞助

合作者

调查人员

出版物和有用的链接

一般刊物

研究记录日期

研究主要日期

学习开始 (实际的)

初级完成 (估计的)

研究完成 (估计的)

研究注册日期

首次提交

首先提交符合 QC 标准的

首次发布 (实际的)

研究记录更新

最后更新发布 (实际的)

上次提交的符合 QC 标准的更新

最后验证

更多信息

与本研究相关的术语

其他相关的 MeSH 术语

其他研究编号

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)？

药物和器械信息、研究文件

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研究美国 FDA 监管的设备产品

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