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T-DM1 og Tucatinib sammenlignet med T-DM1 alene til at forebygge tilbagefald hos mennesker med højrisiko HER2-positiv brystkræft, CompassHER2 RD-forsøget

28. oktober 2025 opdateret af: Alliance for Clinical Trials in Oncology

CompassHER2-forsøgene (omfattende brug af patologisk responsvurdering til at optimere terapi ved HER2-positiv brystkræft) CompassHER2 Residual Disease (RD), et dobbeltblindet, fase III randomiseret forsøg med T-DM1 sammenlignet med T-DM1 og Tucatinib

Dette fase III-studie undersøger, hvor godt trastuzumab emtansin (T-DM1) og tucatinib virker til at forhindre brystkræft i at komme tilbage (tilbagefaldende) hos patienter med høj risiko, HER2-positiv brystkræft. T-DM1 er et monoklonalt antistof, kaldet trastuzumab, forbundet med et kemoterapilægemiddel, kaldet DM1. Trastuzumab er en form for målrettet terapi, fordi det binder sig til specifikke molekyler (receptorer) på overfladen af kræftceller, kendt som HER2-receptorer, og afgiver DM1 for at dræbe dem. Tucatinib kan stoppe væksten af tumorceller ved at blokere nogle af de enzymer, der er nødvendige for cellevækst. At give T-DM1 og tucatinib kan virke bedre til at forhindre brystkræft i at få tilbagefald hos patienter med HER2 positiv brystkræft sammenlignet med T-DM1 alene.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆR MÅL:

I. At bestemme, om den invasive sygdomsfri overlevelse (iDFS) med T-DM1 og tucatinib er overlegen iDFS i kontrolarmen (T-DM1 + placebo), når den administreres til højrisikopatienter med HER2-positiv brystkræft og resterende sygdom efter neoadjuverende HER2-styret behandling.

SEKUNDÆRE MÅL:

I. For at evaluere om behandling med tucatinib plus T-DM1 sammenlignet med behandling med T-DM1 alene (T-DM1 plus placebo) forbedrer følgende:

Ia. Brystkræftfri overlevelse (BCFS). Ib. Fjern recidivfri overlevelse (DRFS). Ic. Hjernemetastasefri overlevelse (BMFS). Id. Samlet overlevelse (OS). II. At evaluere om behandling med tucatinib plus T-DM1 sammenlignet med behandling med T-DM1 alene (T-DM1 plus placebo) reducerer forekomsten af hjernemetastaser.

OVERSIGT: Patienterne randomiseres til 1 af 2 arme.

ARM I: Patienter får T-DM1 intravenøst (IV) over 30-90 minutter på dag 1 og placebo oralt (PO) to gange dagligt (BID) på dag 1-21. Behandlingen gentages hver 21. dag i op til 14 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet.

ARM II: Patienter modtager T-DM1 IV over 30-90 minutter på dag 1 og tucatinib PO BID på dag 1-21. Behandlingen gentages hver 21. dag i op til 14 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet.

Efter afsluttet undersøgelsesbehandling følges patienterne op efter 30 dage, derefter hver 6. måned i 10 år.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

1056

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Canada
- British Columbia
  - Vancouver, British Columbia, Canada, V5Z 4E6
    - BCCA-Vancouver Cancer Centre
- New Brunswick
  - Saint John, New Brunswick, Canada, E2L 4L2
    - Atlantic Health Sciences Corporation-Saint John Regional Hospital
- Ontario
  - London, Ontario, Canada, N6A 4L6
    - London Regional Cancer Program
  - Oshawa, Ontario, Canada, L1G 2B9
    - Lakeridge Health Oshawa
  - Toronto, Ontario, Canada, M4N 3M5
    - Odette Cancer Centre- Sunnybrook Health Sciences Centre
  - Toronto, Ontario, Canada, M5B 1W8
    - Saint Michael's Hospital
- Quebec
  - Québec, Quebec, Canada, G1S 4L8
    - CHU de Quebec-Hopital du Saint-Sacrement (HSS)
- Saskatchewan
  - Regina, Saskatchewan, Canada, S4T 7T1
    - Allan Blair Cancer Centre
  - Saskatoon, Saskatchewan, Canada, S7N 4H4
    - Saskatoon Cancer Centre
Forenede Stater
- Alabama
  - Birmingham, Alabama, Forenede Stater, 35233
    - University of Alabama at Birmingham Cancer Center
  - Fairhope, Alabama, Forenede Stater, 36532
    - Thomas Hospital
  - Mobile, Alabama, Forenede Stater, 36607
    - Mobile Infirmary Medical Center
- Alaska
  - Anchorage, Alaska, Forenede Stater, 98508
    - Anchorage Associates in Radiation Medicine
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Oncology and Hematology LLC
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Women's Cancer Care
  - Anchorage, Alaska, Forenede Stater, 99508
    - Anchorage Oncology Centre
  - Anchorage, Alaska, Forenede Stater, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, Forenede Stater, 99508
    - Providence Alaska Medical Center
  - Anchorage, Alaska, Forenede Stater, 99504
    - Anchorage Radiation Therapy Center
  - Fairbanks, Alaska, Forenede Stater, 99701
    - Fairbanks Memorial Hospital
- Arizona
  - Gilbert, Arizona, Forenede Stater, 85234
    - Banner MD Anderson Cancer Center
  - Kingman, Arizona, Forenede Stater, 86401
    - Kingman Regional Medical Center
  - Phoenix, Arizona, Forenede Stater, 85004
    - Cancer Center at Saint Joseph's
  - Phoenix, Arizona, Forenede Stater, 85006
    - Banner-University Medical Center Phoenix
- Arkansas
  - Fort Smith, Arkansas, Forenede Stater, 72903
    - Mercy Hospital Fort Smith
  - Hot Springs, Arkansas, Forenede Stater, 71913
    - CHI Saint Vincent Cancer Center Hot Springs
  - Jonesboro, Arkansas, Forenede Stater, 72401
    - NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
  - Little Rock, Arkansas, Forenede Stater, 72205
    - University of Arkansas for Medical Sciences
- California
  - Arroyo Grande, California, Forenede Stater, 93420
    - PCR Oncology
  - Arroyo Grande, California, Forenede Stater, 93420
    - Mission Hope Medical Oncology - Arroyo Grande
  - Auburn, California, Forenede Stater, 95602
    - Sutter Auburn Faith Hospital
  - Auburn, California, Forenede Stater, 95603
    - Sutter Cancer Centers Radiation Oncology Services-Auburn
  - Berkeley, California, Forenede Stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Berkeley, California, Forenede Stater, 94702
    - UCSF Cancer Center - Berkeley
  - Beverly Hills, California, Forenede Stater, 90211
    - Tower Cancer Research Foundation
  - Burbank, California, Forenede Stater, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Cameron Park, California, Forenede Stater, 95682
    - Sutter Cancer Centers Radiation Oncology Services-Cameron Park
  - Carmichael, California, Forenede Stater, 95608
    - Mercy San Juan Medical Center
  - Carmichael, California, Forenede Stater, 95608
    - Mercy Cancer Center - Carmichael
  - Castro Valley, California, Forenede Stater, 94546
    - Eden Hospital Medical Center
  - Clovis, California, Forenede Stater, 93611
    - Community Cancer Institute
  - Concord, California, Forenede Stater, 94520
    - John Muir Medical Center-Concord
  - Costa Mesa, California, Forenede Stater, 92627
    - UC Irvine Health Cancer Center-Newport
  - Davis, California, Forenede Stater, 95616
    - Sutter Davis Hospital
  - Duarte, California, Forenede Stater, 91010
    - City of Hope Comprehensive Cancer Center
  - Dublin, California, Forenede Stater, 94568
    - Kaiser Permanente Dublin
  - Dublin, California, Forenede Stater, 94568
    - Epic Care-Dublin
  - Elk Grove, California, Forenede Stater, 95758
    - Mercy Cancer Center - Elk Grove
  - Emeryville, California, Forenede Stater, 94608
    - Bay Area Breast Surgeons Inc
  - Emeryville, California, Forenede Stater, 94608
    - Epic Care Partners in Cancer Care
  - Fremont, California, Forenede Stater, 94538
    - Kaiser Permanente-Fremont
  - Fremont, California, Forenede Stater, 94538
    - Washington Hospital
  - Fremont, California, Forenede Stater, 94538
    - Palo Alto Medical Foundation-Fremont
  - Fresno, California, Forenede Stater, 93720
    - Kaiser Permanente-Fresno
  - Fullerton, California, Forenede Stater, 92835
    - Saint Jude Medical Center
  - Irvine, California, Forenede Stater, 92618
    - City of Hope at Irvine Lennar
  - Irvine, California, Forenede Stater, 92612
    - UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
  - Los Angeles, California, Forenede Stater, 90033
    - USC / Norris Comprehensive Cancer Center
  - Los Angeles, California, Forenede Stater, 90048
    - Cedars Sinai Medical Center
  - Los Angeles, California, Forenede Stater, 90020
    - Keck Medicine of USC Koreatown
  - Los Angeles, California, Forenede Stater, 90033
    - Los Angeles General Medical Center
  - Martinez, California, Forenede Stater, 94553-3156
    - Contra Costa Regional Medical Center
  - Modesto, California, Forenede Stater, 95355
    - Memorial Medical Center
  - Modesto, California, Forenede Stater, 95356
    - Kaiser Permanente-Modesto
  - Mountain View, California, Forenede Stater, 94040
    - Palo Alto Medical Foundation-Camino Division
  - Mountain View, California, Forenede Stater, 94040
    - Palo Alto Medical Foundation-Gynecologic Oncology
  - Newport Beach, California, Forenede Stater, 92663
    - USC Norris Oncology/Hematology-Newport Beach
  - Newport Beach, California, Forenede Stater, 92660
    - City of Hope Newport Beach
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente-Oakland
  - Oakland, California, Forenede Stater, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Forenede Stater, 94609
    - Bay Area Tumor Institute
  - Orange, California, Forenede Stater, 92868
    - UC Irvine Health/Chao Family Comprehensive Cancer Center
  - Orange, California, Forenede Stater, 92868
    - Saint Joseph Hospital - Orange
  - Palm Springs, California, Forenede Stater, 92262
    - Desert Regional Medical Center
  - Palo Alto, California, Forenede Stater, 94304
    - Stanford Cancer Institute Palo Alto
  - Palo Alto, California, Forenede Stater, 94301
    - Palo Alto Medical Foundation Health Care
  - Pasadena, California, Forenede Stater, 91105
    - Huntington Memorial Hospital
  - Pasadena, California, Forenede Stater, 91105
    - Keck Medical Center of USC Pasadena
  - Rancho Mirage, California, Forenede Stater, 92270
    - Eisenhower Medical Center
  - Rocklin, California, Forenede Stater, 95765
    - Mercy Cancer Center - Rocklin
  - Roseville, California, Forenede Stater, 95661
    - Kaiser Permanente-Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Cancer Centers Radiation Oncology Services-Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forenede Stater, 95816
    - Sutter Medical Center Sacramento
  - Sacramento, California, Forenede Stater, 95817
    - University of California Davis Comprehensive Cancer Center
  - Sacramento, California, Forenede Stater, 95814
    - Kaiser Permanente Downtown Commons
  - Sacramento, California, Forenede Stater, 95823
    - Kaiser Permanente-South Sacramento
  - Sacramento, California, Forenede Stater, 95816
    - Mercy Cancer Center - Sacramento
  - Salinas, California, Forenede Stater, 93901
    - Salinas Valley Memorial
  - San Francisco, California, Forenede Stater, 94115
    - Kaiser Permanente-San Francisco
  - San Francisco, California, Forenede Stater, 94158
    - UCSF Medical Center-Mission Bay
  - San Francisco, California, Forenede Stater, 94115
    - California Pacific Medical Center-Pacific Campus
  - San Francisco, California, Forenede Stater, 94110
    - Zuckerberg San Francisco General Hospital
  - San Jose, California, Forenede Stater, 95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Jose, California, Forenede Stater, 95124
    - Stanford Cancer Center South Bay
  - San Leandro, California, Forenede Stater, 94577
    - Kaiser Permanente San Leandro
  - San Luis Obispo, California, Forenede Stater, 93401
    - Pacific Central Coast Health Center-San Luis Obispo
  - San Mateo, California, Forenede Stater, 94402
    - UCSF Cancer Center - San Mateo
  - San Rafael, California, Forenede Stater, 94903
    - Kaiser San Rafael-Gallinas
  - Santa Clara, California, Forenede Stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Cruz, California, Forenede Stater, 95065
    - Palo Alto Medical Foundation-Santa Cruz
  - Santa Maria, California, Forenede Stater, 93444
    - Mission Hope Medical Oncology - Santa Maria
  - Santa Monica, California, Forenede Stater, 90404
    - Saint John's Cancer Institute
  - Santa Rosa, California, Forenede Stater, 95403
    - Kaiser Permanente-Santa Rosa
  - Santa Rosa, California, Forenede Stater, 95403
    - Sutter Pacific Medical Foundation
  - Santa Rosa, California, Forenede Stater, 95403
    - Providence Medical Foundation - Santa Rosa
  - Santa Rosa, California, Forenede Stater, 95405
    - Providence Santa Rosa Memorial Hospital
  - South Pasadena, California, Forenede Stater, 91030
    - City of Hope South Pasadena
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente-South San Francisco
  - St. Helena, California, Forenede Stater, 94574
    - Saint Helena Hospital
  - Sunnyvale, California, Forenede Stater, 94086
    - Palo Alto Medical Foundation-Sunnyvale
  - Torrance, California, Forenede Stater, 90505
    - Torrance Memorial Physician Network - Cancer Care
  - Torrance, California, Forenede Stater, 90503
    - City of Hope South Bay
  - Upland, California, Forenede Stater, 91786
    - City of Hope Upland
  - Vacaville, California, Forenede Stater, 95687
    - Sutter Cancer Centers Radiation Oncology Services-Vacaville
  - Vallejo, California, Forenede Stater, 94589
    - Kaiser Permanente-Vallejo
  - Vallejo, California, Forenede Stater, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek, California, Forenede Stater, 94596
    - Kaiser Permanente-Walnut Creek
  - Walnut Creek, California, Forenede Stater, 94598
    - John Muir Medical Center-Walnut Creek
  - Walnut Creek, California, Forenede Stater, 94597
    - Epic Care Cyberknife Center
  - Woodland, California, Forenede Stater, 95695
    - Woodland Memorial Hospital
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Forenede Stater, 80012
    - The Medical Center of Aurora
  - Aurora, Colorado, Forenede Stater, 80045
    - UCHealth University of Colorado Hospital
  - Boulder, Colorado, Forenede Stater, 80303
    - Boulder Community Foothills Hospital
  - Boulder, Colorado, Forenede Stater, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Centennial, Colorado, Forenede Stater, 80112
    - Rocky Mountain Cancer Centers - Centennial
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Forenede Stater, 80909
    - UCHealth Memorial Hospital Central
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Rocky Mountain Cancer Centers-Penrose
  - Colorado Springs, Colorado, Forenede Stater, 80920
    - Memorial Hospital North
  - Denver, Colorado, Forenede Stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forenede Stater, 80218
    - SCL Health Saint Joseph Hospital
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Forenede Stater, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Forenede Stater, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Forenede Stater, 80204
    - Cancer Center of Colorado at Sloan's Lake
  - Denver, Colorado, Forenede Stater, 80209
    - The Women's Imaging Center
  - Denver, Colorado, Forenede Stater, 80206
    - National Jewish Health-Main Campus
  - Denver, Colorado, Forenede Stater, 80220
    - Western Surgical Care
  - Denver, Colorado, Forenede Stater, 80206
    - UCHealth - Cherry Creek
  - Durango, Colorado, Forenede Stater, 81301
    - Mercy Medical Center
  - Durango, Colorado, Forenede Stater, 81301
    - Southwest Oncology PC
  - Edwards, Colorado, Forenede Stater, 81632
    - Shaw Cancer Center
  - Englewood, Colorado, Forenede Stater, 80113
    - Mountain Blue Cancer Care Center - Swedish
  - Englewood, Colorado, Forenede Stater, 80113
    - Swedish Medical Center
  - Englewood, Colorado, Forenede Stater, 80113
    - Rocky Mountain Cancer Centers - Swedish
  - Englewood, Colorado, Forenede Stater, 80113
    - The Melanoma and Skin Cancer Institute
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Fort Collins, Colorado, Forenede Stater, 80528
    - Cancer Care and Hematology-Fort Collins
  - Golden, Colorado, Forenede Stater, 80401
    - National Jewish Health-Western Hematology Oncology
  - Golden, Colorado, Forenede Stater, 80401
    - SCL Health Cancer Centers of Colorado - Lutheran Medical Center
  - Grand Junction, Colorado, Forenede Stater, 81501
    - Saint Mary's Hospital and Regional Medical Center
  - Grand Junction, Colorado, Forenede Stater, 81505
    - Grand Valley Oncology
  - Greeley, Colorado, Forenede Stater, 80631
    - UCHealth Greeley Hospital
  - Greeley, Colorado, Forenede Stater, 80631
    - Banner North Colorado Medical Center
  - Highlands Ranch, Colorado, Forenede Stater, 80129
    - UCHealth Highlands Ranch Hospital
  - Lafayette, Colorado, Forenede Stater, 80026
    - Good Samaritan Medical Center
  - Lakewood, Colorado, Forenede Stater, 80228
    - Saint Anthony Hospital
  - Lakewood, Colorado, Forenede Stater, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Littleton, Colorado, Forenede Stater, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton, Colorado, Forenede Stater, 80122
    - Littleton Adventist Hospital
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Lone Tree, Colorado, Forenede Stater, 80124
    - UCHealth Lone Tree Health Center
  - Longmont, Colorado, Forenede Stater, 80501
    - Longmont United Hospital
  - Longmont, Colorado, Forenede Stater, 80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland, Colorado, Forenede Stater, 80538
    - Medical Center of the Rockies
  - Loveland, Colorado, Forenede Stater, 80539
    - Banner McKee Medical Center
  - Parker, Colorado, Forenede Stater, 80138
    - Parker Adventist Hospital
  - Pueblo, Colorado, Forenede Stater, 81004
    - Saint Mary Corwin Medical Center
  - Thornton, Colorado, Forenede Stater, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Thornton, Colorado, Forenede Stater, 80260
    - National Jewish Health-Northern Hematology Oncology
  - Wheat Ridge, Colorado, Forenede Stater, 80033
    - SCL Health Lutheran Medical Center
- Connecticut
  - Bridgeport, Connecticut, Forenede Stater, 06606
    - Hartford HealthCare - Saint Vincent's Medical Center
  - Danbury, Connecticut, Forenede Stater, 06810
    - Danbury Hospital
  - Fairfield, Connecticut, Forenede Stater, 06824
    - Smilow Cancer Hospital Care Center-Fairfield
  - Glastonbury, Connecticut, Forenede Stater, 06033
    - Smilow Cancer Hospital Care Center at Glastonbury
  - Hartford, Connecticut, Forenede Stater, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Hartford, Connecticut, Forenede Stater, 06102
    - Hartford Hospital
  - Meriden, Connecticut, Forenede Stater, 06451
    - Midstate Medical Center
  - New Britain, Connecticut, Forenede Stater, 06050
    - The Hospital of Central Connecticut
  - New Haven, Connecticut, Forenede Stater, 06520
    - Yale University
  - North Haven, Connecticut, Forenede Stater, 06473
    - Yale-New Haven Hospital North Haven Medical Center
  - Norwalk, Connecticut, Forenede Stater, 06856
    - Norwalk Hospital
  - Stamford, Connecticut, Forenede Stater, 06904
    - Stamford Hospital/Bennett Cancer Center
  - Torrington, Connecticut, Forenede Stater, 06790
    - Smilow Cancer Hospital-Torrington Care Center
  - Trumbull, Connecticut, Forenede Stater, 06611
    - Smilow Cancer Hospital Care Center-Trumbull
  - Waterbury, Connecticut, Forenede Stater, 06708
    - Smilow Cancer Hospital-Waterbury Care Center
  - Waterford, Connecticut, Forenede Stater, 06385
    - Smilow Cancer Hospital Care Center - Waterford
- Delaware
  - Frankford, Delaware, Forenede Stater, 19945
    - Beebe South Coastal Health Campus
  - Lewes, Delaware, Forenede Stater, 19958
    - Beebe Medical Center
  - Newark, Delaware, Forenede Stater, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Forenede Stater, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, Forenede Stater, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Forenede Stater, 19718
    - Christiana Care Health System-Christiana Hospital
  - Rehoboth Beach, Delaware, Forenede Stater, 19971
    - Beebe Health Campus
  - Seaford, Delaware, Forenede Stater, 19973
    - TidalHealth Nanticoke / Allen Cancer Center
  - Wilmington, Delaware, Forenede Stater, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington D.C., District of Columbia, Forenede Stater, 20010
    - Medstar Washington Hospital Center
  - Washington D.C., District of Columbia, Forenede Stater, 20002
    - Kaiser Permanente-Capitol Hill Medical Center
  - Washington D.C., District of Columbia, Forenede Stater, 20007
    - MedStar Georgetown University Hospital
  - Washington D.C., District of Columbia, Forenede Stater, 20016
    - Sibley Memorial Hospital
- Florida
  - Altamonte Springs, Florida, Forenede Stater, 32701
    - AdventHealth Altamonte
  - Aventura, Florida, Forenede Stater, 33180
    - Mount Sinai Comprehensive Cancer Center at Aventura
  - Aventura, Florida, Forenede Stater, 33180
    - UM Sylvester Comprehensive Cancer Center at Aventura
  - Boca Raton, Florida, Forenede Stater, 33486
    - Boca Raton Regional Hospital
  - Celebration, Florida, Forenede Stater, 34747
    - AdventHealth Celebration
  - Clearwater, Florida, Forenede Stater, 33756
    - Morton Plant Hospital
  - Coral Gables, Florida, Forenede Stater, 33146
    - UM Sylvester Comprehensive Cancer Center at Coral Gables
  - Deerfield Beach, Florida, Forenede Stater, 33442
    - UM Sylvester Comprehensive Cancer Center at Deerfield Beach
  - Fort Lauderdale, Florida, Forenede Stater, 33308
    - Holy Cross Hospital
  - Hollywood, Florida, Forenede Stater, 33021
    - Memorial Regional Hospital/Joe DiMaggio Children's Hospital
  - Jacksonville, Florida, Forenede Stater, 32224-9980
    - Mayo Clinic in Florida
  - Kissimmee, Florida, Forenede Stater, 34744
    - AdventHealth Kissimmee
  - Miami, Florida, Forenede Stater, 33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami, Florida, Forenede Stater, 33176
    - UM Sylvester Comprehensive Cancer Center at Kendall
  - Miami Beach, Florida, Forenede Stater, 33140
    - Mount Sinai Medical Center
  - Orlando, Florida, Forenede Stater, 32806
    - Orlando Health Cancer Institute
  - Orlando, Florida, Forenede Stater, 32803
    - AdventHealth Orlando
  - Orlando, Florida, Forenede Stater, 32803
    - AdventHealth Medical Group Urology at Orlando
  - Orlando, Florida, Forenede Stater, 32822
    - AdventHealth East Orlando
  - Pembroke Pines, Florida, Forenede Stater, 33028
    - Memorial Hospital West
  - Pensacola, Florida, Forenede Stater, 32504
    - Sacred Heart Hospital
  - Plantation, Florida, Forenede Stater, 33324
    - UM Sylvester Comprehensive Cancer Center at Plantation
  - Safety Harbor, Florida, Forenede Stater, 34695
    - Mease Countryside Hospital
  - St. Petersburg, Florida, Forenede Stater, 33705
    - Saint Anthony's Hospital Cancer Care Center
  - Tampa, Florida, Forenede Stater, 33606
    - Tampa General Hospital
  - Tampa, Florida, Forenede Stater, 33607
    - Saint Joseph's Hospital/Children's Hospital-Tampa
  - Winter Haven, Florida, Forenede Stater, 33881
    - Winter Haven Hospital
  - Winter Park, Florida, Forenede Stater, 32792
    - AdventHealth Winter Park
- Georgia
  - Albany, Georgia, Forenede Stater, 31701
    - Phoebe Putney Memorial Hospital
  - Athens, Georgia, Forenede Stater, 30607
    - University Cancer and Blood Center LLC
  - Atlanta, Georgia, Forenede Stater, 30308
    - Emory University Hospital Midtown
  - Atlanta, Georgia, Forenede Stater, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, Forenede Stater, 30342
    - Emory Saint Joseph's Hospital
  - Atlanta, Georgia, Forenede Stater, 30303
    - Grady Health System
  - Atlanta, Georgia, Forenede Stater, 30342
    - Northside Hospital
  - Augusta, Georgia, Forenede Stater, 30901
    - Augusta Oncology Associates PC-D'Antignac
  - Augusta, Georgia, Forenede Stater, 30909
    - Augusta Oncology Associates PC-Wheeler
  - Decatur, Georgia, Forenede Stater, 30033
    - Atlanta VA Medical Center
  - Duluth, Georgia, Forenede Stater, 30096
    - Northside Hospital - Duluth
  - Lawrenceville, Georgia, Forenede Stater, 30046
    - Northside Hospital - Gwinnett
  - Newnan, Georgia, Forenede Stater, 30265
    - CTCA at Southeastern Regional Medical Center
  - Savannah, Georgia, Forenede Stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Savannah, Georgia, Forenede Stater, 31404
    - Memorial Health University Medical Center
  - Savannah, Georgia, Forenede Stater, 31404
    - Summit Cancer Care-Memorial
  - Snellville, Georgia, Forenede Stater, 30078
    - Suburban Hematology Oncology Associates - Snellville
- Hawaii
  - Hilo, Hawaii, Forenede Stater, 96720
    - Island Urology-Hilo
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - The Cancer Center of Hawaii-Liliha
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Hawaii Cancer Care Inc - Waterfront Plaza
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Cancer Cenrer - POB I
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forenede Stater, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Hawaii Cancer Care Inc-Liliha
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Kuakini Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Queen's Cancer Center - Kuakini
  - Honolulu, Hawaii, Forenede Stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Island Urology
  - Honolulu, Hawaii, Forenede Stater, 96819
    - Kaiser Permanente Moanalua Medical Center
  - Lihue, Hawaii, Forenede Stater, 96766
    - Wilcox Memorial Hospital and Kauai Medical Clinic
  - ‘Aiea, Hawaii, Forenede Stater, 96701
    - Hawaii Cancer Care - Westridge
  - ‘Aiea, Hawaii, Forenede Stater, 96701
    - Pali Momi Medical Center
  - ‘Aiea, Hawaii, Forenede Stater, 96701
    - Queen's Cancer Center - Pearlridge
  - ‘Aiea, Hawaii, Forenede Stater, 96701
    - The Cancer Center of Hawaii-Pali Momi
- Idaho
  - Boise, Idaho, Forenede Stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Forenede Stater, 83712
    - Saint Luke's Cancer Institute - Boise
  - Caldwell, Idaho, Forenede Stater, 83605
    - Saint Alphonsus Cancer Care Center-Caldwell
  - Coeur d'Alene, Idaho, Forenede Stater, 83814
    - Kootenai Health - Coeur d'Alene
  - Emmett, Idaho, Forenede Stater, 83617
    - Walter Knox Memorial Hospital
  - Fruitland, Idaho, Forenede Stater, 83619
    - Saint Luke's Cancer Institute - Fruitland
  - Meridian, Idaho, Forenede Stater, 83642
    - Idaho Urologic Institute-Meridian
  - Meridian, Idaho, Forenede Stater, 83642
    - Saint Luke's Cancer Institute - Meridian
  - Nampa, Idaho, Forenede Stater, 83686
    - Saint Luke's Cancer Institute - Nampa
  - Nampa, Idaho, Forenede Stater, 83687
    - Saint Alphonsus Cancer Care Center-Nampa
  - Post Falls, Idaho, Forenede Stater, 83854
    - Kootenai Clinic Cancer Services - Post Falls
  - Sandpoint, Idaho, Forenede Stater, 83864
    - Kootenai Clinic Cancer Services - Sandpoint
  - Twin Falls, Idaho, Forenede Stater, 83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Alton, Illinois, Forenede Stater, 62002
    - Saint Anthony's Health
  - Arlington Heights, Illinois, Forenede Stater, 60005
    - Northwest Community Hospital
  - Aurora, Illinois, Forenede Stater, 60504
    - Rush - Copley Medical Center
  - Barrington, Illinois, Forenede Stater, 60010
    - Advocate Good Shepherd Hospital
  - Bloomington, Illinois, Forenede Stater, 61704
    - Illinois CancerCare-Bloomington
  - Canton, Illinois, Forenede Stater, 61520
    - Illinois CancerCare-Canton
  - Carbondale, Illinois, Forenede Stater, 62902
    - Memorial Hospital of Carbondale
  - Carterville, Illinois, Forenede Stater, 62918
    - SIH Cancer Institute
  - Carthage, Illinois, Forenede Stater, 62321
    - Illinois CancerCare-Carthage
  - Centralia, Illinois, Forenede Stater, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Forenede Stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forenede Stater, 60612
    - Rush University Medical Center
  - Chicago, Illinois, Forenede Stater, 60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago, Illinois, Forenede Stater, 60612
    - University of Illinois
  - Chicago, Illinois, Forenede Stater, 60612
    - John H Stroger Jr Hospital of Cook County
  - Chicago, Illinois, Forenede Stater, 60608
    - Mount Sinai Hospital Medical Center
  - Chicago, Illinois, Forenede Stater, 60625
    - Swedish Covenant Hospital
  - Chicago, Illinois, Forenede Stater, 60657
    - Advocate Illinois Masonic Medical Center
  - Crystal Lake, Illinois, Forenede Stater, 60014
    - AMG Crystal Lake - Oncology
  - Danville, Illinois, Forenede Stater, 61832
    - Carle at The Riverfront
  - DeKalb, Illinois, Forenede Stater, 60115
    - Northwestern Medicine Cancer Center Kishwaukee
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forenede Stater, 62526
    - Cancer Care Specialists of Illinois - Decatur
  - Dixon, Illinois, Forenede Stater, 61021
    - Illinois CancerCare-Dixon
  - Downers Grove, Illinois, Forenede Stater, 60515
    - Advocate Good Samaritan Hospital
  - Effingham, Illinois, Forenede Stater, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Forenede Stater, 62401
    - Carle Physician Group-Effingham
  - Elgin, Illinois, Forenede Stater, 60123
    - Advocate Sherman Hospital
  - Eureka, Illinois, Forenede Stater, 61530
    - Illinois CancerCare-Eureka
  - Evanston, Illinois, Forenede Stater, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare-Galesburg
  - Geneva, Illinois, Forenede Stater, 60134
    - Northwestern Medicine Cancer Center Delnor
  - Glenview, Illinois, Forenede Stater, 60026
    - NorthShore University HealthSystem-Glenbrook Hospital
  - Glenview, Illinois, Forenede Stater, 60026
    - Northwestern Medicine Glenview Outpatient Center
  - Grayslake, Illinois, Forenede Stater, 60030
    - Northwestern Medicine Grayslake Outpatient Center
  - Harvey, Illinois, Forenede Stater, 60426
    - Ingalls Memorial Hospital
  - Hazel Crest, Illinois, Forenede Stater, 60429
    - Advocate South Suburban Hospital
  - Highland Park, Illinois, Forenede Stater, 60035
    - NorthShore University HealthSystem-Highland Park Hospital
  - Kewanee, Illinois, Forenede Stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Lake Forest, Illinois, Forenede Stater, 60045
    - Northwestern Medicine Lake Forest Hospital
  - Libertyville, Illinois, Forenede Stater, 60048
    - Condell Memorial Hospital
  - Libertyville, Illinois, Forenede Stater, 60048
    - AMG Libertyville - Oncology
  - Macomb, Illinois, Forenede Stater, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, Forenede Stater, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Mount Vernon, Illinois, Forenede Stater, 62864
    - Good Samaritan Regional Health Center
  - New Lenox, Illinois, Forenede Stater, 60451
    - UC Comprehensive Cancer Center at Silver Cross
  - O'Fallon, Illinois, Forenede Stater, 62269
    - Cancer Care Center of O'Fallon
  - Oak Lawn, Illinois, Forenede Stater, 60453-2699
    - Advocate Christ Medical Center
  - Orland Park, Illinois, Forenede Stater, 60462
    - University of Chicago Medicine-Orland Park
  - Orland Park, Illinois, Forenede Stater, 60462
    - Northwestern Medicine Orland Park
  - Ottawa, Illinois, Forenede Stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Park Ridge, Illinois, Forenede Stater, 60068
    - Advocate Lutheran General Hospital
  - Pekin, Illinois, Forenede Stater, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Forenede Stater, 61554
    - OSF Saint Francis Radiation Oncology at Pekin
  - Peoria, Illinois, Forenede Stater, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forenede Stater, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Forenede Stater, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Forenede Stater, 61615
    - OSF Saint Francis Radiation Oncology at Peoria Cancer Center
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forenede Stater, 61354
    - Valley Radiation Oncology
  - Princeton, Illinois, Forenede Stater, 61356
    - Illinois CancerCare-Princeton
  - Rockford, Illinois, Forenede Stater, 61108
    - OSF Saint Anthony Medical Center
  - Rockford, Illinois, Forenede Stater, 61114
    - UW Health Carbone Cancer Center Rockford
  - Shiloh, Illinois, Forenede Stater, 62269
    - Memorial Hospital East
  - Silvis, Illinois, Forenede Stater, 61282
    - Genesis Cancer Center - Silvis
  - Springfield, Illinois, Forenede Stater, 62781
    - Memorial Medical Center
  - Springfield, Illinois, Forenede Stater, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Forenede Stater, 62702
    - Springfield Clinic
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Forenede Stater, 61801
    - The Carle Foundation Hospital
  - Warrenville, Illinois, Forenede Stater, 60555
    - Northwestern Medicine Cancer Center Warrenville
  - Washington, Illinois, Forenede Stater, 61571
    - Illinois CancerCare - Washington
  - Yorkville, Illinois, Forenede Stater, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Carmel, Indiana, Forenede Stater, 46032
    - IU Health North Hospital
  - Indianapolis, Indiana, Forenede Stater, 46237
    - Franciscan Health Indianapolis
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Forenede Stater, 46219
    - Community Cancer Center East
  - Indianapolis, Indiana, Forenede Stater, 46227
    - Community Cancer Center South
  - Indianapolis, Indiana, Forenede Stater, 46256
    - Community Cancer Center North
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Sidney and Lois Eskenazi Hospital
  - Kokomo, Indiana, Forenede Stater, 46904
    - Community Howard Regional Health
  - Lafayette, Indiana, Forenede Stater, 47905
    - Franciscan Saint Elizabeth Health - Lafayette East
  - Michigan City, Indiana, Forenede Stater, 46360
    - Woodland Cancer Care Center
  - Mooresville, Indiana, Forenede Stater, 46158
    - Franciscan Health Mooresville
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Health
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - Mary Greeley Medical Center
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic - Ames
  - Ankeny, Iowa, Forenede Stater, 50023
    - Mission Cancer and Blood - Ankeny
  - Boone, Iowa, Forenede Stater, 50036
    - McFarland Clinic - Boone
  - Carroll, Iowa, Forenede Stater, 51401
    - Saint Anthony Regional Hospital
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Mercy Hospital
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Oncology Associates at Mercy Medical Center
  - Cedar Rapids, Iowa, Forenede Stater, 52402
    - Physicians' Clinic of Iowa PC
  - Clive, Iowa, Forenede Stater, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, Forenede Stater, 50325
    - Mission Cancer and Blood - West Des Moines
  - Council Bluffs, Iowa, Forenede Stater, 51503
    - Alegent Health Mercy Hospital
  - Council Bluffs, Iowa, Forenede Stater, 51503
    - Heartland Oncology and Hematology LLP
  - Council Bluffs, Iowa, Forenede Stater, 51503
    - Methodist Jennie Edmundson Hospital
  - Creston, Iowa, Forenede Stater, 50801
    - Greater Regional Medical Center
  - Davenport, Iowa, Forenede Stater, 52803
    - Genesis Medical Center - East Campus
  - Davenport, Iowa, Forenede Stater, 52804
    - Genesis Cancer Care Institute
  - Davenport, Iowa, Forenede Stater, 52807
    - Iowa Cancer Specialists
  - Des Moines, Iowa, Forenede Stater, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50314
    - Broadlawns Medical Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mission Cancer and Blood - Laurel
  - Des Moines, Iowa, Forenede Stater, 50316
    - Iowa Lutheran Hospital
  - Des Moines, Iowa, Forenede Stater, 50309
    - Mission Cancer and Blood - Des Moines
  - Fort Dodge, Iowa, Forenede Stater, 50501
    - Trinity Regional Medical Center
  - Fort Dodge, Iowa, Forenede Stater, 50501
    - McFarland Clinic - Trinity Cancer Center
  - Jefferson, Iowa, Forenede Stater, 50129
    - McFarland Clinic - Jefferson
  - Marshalltown, Iowa, Forenede Stater, 50158
    - McFarland Clinic - Marshalltown
  - Sioux City, Iowa, Forenede Stater, 51101
    - Siouxland Regional Cancer Center
  - West Des Moines, Iowa, Forenede Stater, 50266-7700
    - Methodist West Hospital
  - West Des Moines, Iowa, Forenede Stater, 50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Chanute, Kansas, Forenede Stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forenede Stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas - El Dorado
  - Garden City, Kansas, Forenede Stater, 67846
    - Central Care Cancer Center - Garden City
  - Great Bend, Kansas, Forenede Stater, 67530
    - Central Care Cancer Center - Great Bend
  - Hays, Kansas, Forenede Stater, 67601
    - HaysMed
  - Independence, Kansas, Forenede Stater, 67301
    - Cancer Center of Kansas-Independence
  - Kingman, Kansas, Forenede Stater, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Forenede Stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forenede Stater, 67905
    - Cancer Center of Kansas-Liberal
  - Manhattan, Kansas, Forenede Stater, 66502
    - Cancer Center of Kansas-Manhattan
  - McPherson, Kansas, Forenede Stater, 67460
    - Cancer Center of Kansas - McPherson
  - Newton, Kansas, Forenede Stater, 67114
    - Cancer Center of Kansas - Newton
  - Olathe, Kansas, Forenede Stater, 66061
    - Olathe Health Cancer Center
  - Overland Park, Kansas, Forenede Stater, 66210
    - University of Kansas Cancer Center-Overland Park
  - Overland Park, Kansas, Forenede Stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forenede Stater, 66211
    - University of Kansas Hospital-Indian Creek Campus
  - Parsons, Kansas, Forenede Stater, 67357
    - Cancer Center of Kansas - Parsons
  - Pittsburg, Kansas, Forenede Stater, 66762
    - Ascension Via Christi - Pittsburg
  - Pittsburg, Kansas, Forenede Stater, 66762
    - Freeman Physician Group of Pittsburg
  - Pratt, Kansas, Forenede Stater, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Forenede Stater, 67401
    - Salina Regional Health Center
  - Salina, Kansas, Forenede Stater, 67401
    - Cancer Center of Kansas - Salina
  - Topeka, Kansas, Forenede Stater, 66606
    - University of Kansas Health System Saint Francis Campus
  - Wellington, Kansas, Forenede Stater, 67152
    - Cancer Center of Kansas - Wellington
  - Westwood, Kansas, Forenede Stater, 66205
    - University of Kansas Hospital-Westwood Cancer Center
  - Wichita, Kansas, Forenede Stater, 67214
    - Ascension Via Christi Hospitals Wichita
  - Wichita, Kansas, Forenede Stater, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas - Wichita
  - Winfield, Kansas, Forenede Stater, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Ashland, Kentucky, Forenede Stater, 41101
    - King's Daughter's Medical Center
  - Bardstown, Kentucky, Forenede Stater, 40004
    - Flaget Memorial Hospital
  - Corbin, Kentucky, Forenede Stater, 40701
    - Baptist Health Corbin
  - Corbin, Kentucky, Forenede Stater, 40701
    - Commonwealth Cancer Center-Corbin
  - Lexington, Kentucky, Forenede Stater, 40536
    - University of Kentucky/Markey Cancer Center
  - Lexington, Kentucky, Forenede Stater, 40504
    - Saint Joseph Radiation Oncology Resource Center
  - Lexington, Kentucky, Forenede Stater, 40509
    - Saint Joseph Hospital East
  - Lexington, Kentucky, Forenede Stater, 40503
    - Baptist Health Lexington
  - London, Kentucky, Forenede Stater, 40741
    - Saint Joseph London
  - Louisville, Kentucky, Forenede Stater, 40202
    - Jewish Hospital
  - Louisville, Kentucky, Forenede Stater, 40245
    - UofL Health Medical Center Northeast
  - Louisville, Kentucky, Forenede Stater, 40207
    - Baptist Health Louisville
  - Louisville, Kentucky, Forenede Stater, 40215
    - Saints Mary and Elizabeth Hospital
  - Shepherdsville, Kentucky, Forenede Stater, 40165
    - Jewish Hospital Medical Center South
- Louisiana
  - Metairie, Louisiana, Forenede Stater, 70006
    - East Jefferson General Hospital
  - New Orleans, Louisiana, Forenede Stater, 70112
    - University Medical Center New Orleans
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Louisiana State University Health Science Center
  - Shreveport, Louisiana, Forenede Stater, 71103
    - LSU Health Sciences Center at Shreveport
- Maine
  - Augusta, Maine, Forenede Stater, 04330
    - Harold Alfond Center for Cancer Care
  - Biddeford, Maine, Forenede Stater, 04005
    - MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
  - Brewer, Maine, Forenede Stater, 04412
    - Lafayette Family Cancer Center-EMMC
  - Kennebunk, Maine, Forenede Stater, 04043
    - Maine Center for Cancer Medicine-Kennebunk
  - Sanford, Maine, Forenede Stater, 04073
    - MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
  - Scarborough, Maine, Forenede Stater, 04074
    - Maine Center for Cancer Medicine-Scarborough
  - South Portland, Maine, Forenede Stater, 04106
    - Maine Medical Partners - South Portland
  - Topsham, Maine, Forenede Stater, 04086
    - Maine Center for Cancer Medicine-Topsham
  - York Village, Maine, Forenede Stater, 03909
    - York Hospital
- Maryland
  - Annapolis, Maryland, Forenede Stater, 21401
    - Luminis Health Anne Arundel Medical Center
  - Baltimore, Maryland, Forenede Stater, 21237
    - MedStar Franklin Square Medical Center/Weinberg Cancer Institute
  - Baltimore, Maryland, Forenede Stater, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Forenede Stater, 21204
    - Greater Baltimore Medical Center
  - Baltimore, Maryland, Forenede Stater, 21244
    - Kaiser Permanente-Woodlawn Medical Center
  - Baltimore, Maryland, Forenede Stater, 21239
    - MedStar Good Samaritan Hospital
  - Bel Air, Maryland, Forenede Stater, 21014
    - UM Upper Chesapeake Medical Center
  - Bethesda, Maryland, Forenede Stater, 20889-5600
    - Walter Reed National Military Medical Center
  - Cumberland, Maryland, Forenede Stater, 21502
    - UPMC Western Maryland
  - Easton, Maryland, Forenede Stater, 21601
    - University of Maryland Shore Medical Center at Easton
  - Gaithersburg, Maryland, Forenede Stater, 20879
    - Kaiser Permanente-Gaithersburg Medical Center
  - Kensington, Maryland, Forenede Stater, 20895
    - Kaiser Permanente - Kensington Medical Center
  - Largo, Maryland, Forenede Stater, 20774
    - Kaiser Permanente - Largo Medical Center
  - Lutherville, Maryland, Forenede Stater, 21093
    - Kaiser Permanente Lutherville - Timonium Medical Center
  - Olney, Maryland, Forenede Stater, 20832
    - Medstar Montgomery Medical Center
  - Westminster, Maryland, Forenede Stater, 21157
    - William E Kahlert Regional Cancer Center/Sinai Hospital
- Massachusetts
  - Beverly, Massachusetts, Forenede Stater, 01915
    - Beverly Hospital
  - Boston, Massachusetts, Forenede Stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forenede Stater, 02215
    - Dana-Farber Cancer Institute
  - Boston, Massachusetts, Forenede Stater, 02111
    - Tufts Medical Center
  - Boston, Massachusetts, Forenede Stater, 02118
    - Boston Medical Center
  - Burlington, Massachusetts, Forenede Stater, 01805
    - Lahey Hospital and Medical Center
  - Foxborough, Massachusetts, Forenede Stater, 02035
    - Dana-Farber Cancer Institute at Foxborough
  - Gloucester, Massachusetts, Forenede Stater, 01930
    - Addison Gilbert Hospital
  - Hyannis, Massachusetts, Forenede Stater, 02601
    - Cape Cod Hospital
  - Lowell, Massachusetts, Forenede Stater, 01854
    - Lowell General Hospital
  - Milford, Massachusetts, Forenede Stater, 01757
    - Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
  - Peabody, Massachusetts, Forenede Stater, 01960
    - Lahey Medical Center-Peabody
  - South Weymouth, Massachusetts, Forenede Stater, 02190
    - Dana-Farber/Brigham and Women's Cancer Center at South Shore
  - Winchester, Massachusetts, Forenede Stater, 01890
    - Winchester Hospital
  - Worcester, Massachusetts, Forenede Stater, 01655
    - UMass Memorial Medical Center - University Campus
- Michigan
  - Adrian, Michigan, Forenede Stater, 49221
    - Hickman Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48109
    - University of Michigan Comprehensive Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - Trinity Health Saint Joseph Mercy Hospital Ann Arbor
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Bronson Battle Creek
  - Brighton, Michigan, Forenede Stater, 48114
    - Trinity Health IHA Medical Group Hematology Oncology - Brighton
  - Brighton, Michigan, Forenede Stater, 48114
    - Trinity Health Medical Center - Brighton
  - Canton, Michigan, Forenede Stater, 48188
    - Trinity Health IHA Medical Group Hematology Oncology - Canton
  - Canton, Michigan, Forenede Stater, 48188
    - Trinity Health Medical Center - Canton
  - Caro, Michigan, Forenede Stater, 48723
    - Caro Cancer Center
  - Chelsea, Michigan, Forenede Stater, 48118
    - Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
  - Chelsea, Michigan, Forenede Stater, 48118
    - Chelsea Hospital
  - Clarkston, Michigan, Forenede Stater, 48346
    - Hematology Oncology Consultants-Clarkston
  - Clarkston, Michigan, Forenede Stater, 48346
    - Newland Medical Associates-Clarkston
  - Dearborn, Michigan, Forenede Stater, 48124
    - Corewell Health Dearborn Hospital
  - Detroit, Michigan, Forenede Stater, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Detroit, Michigan, Forenede Stater, 48236
    - Ascension Saint John Hospital
  - East China Township, Michigan, Forenede Stater, 48054
    - Great Lakes Cancer Management Specialists-Doctors Park
  - Farmington Hills, Michigan, Forenede Stater, 48334
    - Weisberg Cancer Treatment Center
  - Farmington Hills, Michigan, Forenede Stater, 48336
    - Corewell Health Farmington Hills Hospital
  - Flint, Michigan, Forenede Stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesee Cancer and Blood Disease Treatment Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesee Hematology Oncology PC
  - Flint, Michigan, Forenede Stater, 48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Trinity Health Grand Rapids Hospital
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Corewell Health Grand Rapids Hospitals - Butterworth Hospital
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Academic Hematology Oncology Specialists
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Michigan Breast Specialists-Grosse Pointe Woods
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49009
    - Ascension Borgess Cancer Center
  - Lansing, Michigan, Forenede Stater, 48912
    - University of Michigan Health - Sparrow Lansing
  - Livonia, Michigan, Forenede Stater, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Livonia, Michigan, Forenede Stater, 48154
    - Hope Cancer Clinic
  - Macomb, Michigan, Forenede Stater, 48044
    - Great Lakes Cancer Management Specialists-Macomb Medical Campus
  - Macomb, Michigan, Forenede Stater, 48044
    - Michigan Breast Specialists-Macomb Township
  - Marlette, Michigan, Forenede Stater, 48453
    - Saint Mary's Oncology/Hematology Associates of Marlette
  - Midland, Michigan, Forenede Stater, 48670
    - MyMichigan Medical Center Midland
  - Monroe, Michigan, Forenede Stater, 48162
    - Toledo Clinic Cancer Centers-Monroe
  - Muskegon, Michigan, Forenede Stater, 49444
    - Trinity Health Muskegon Hospital
  - Niles, Michigan, Forenede Stater, 49120
    - Corewell Health Lakeland Hospitals - Niles Hospital
  - Norton Shores, Michigan, Forenede Stater, 49444
    - Cancer and Hematology Centers of Western Michigan - Norton Shores
  - Novi, Michigan, Forenede Stater, 48374
    - Ascension Providence Hospitals - Novi
  - Pontiac, Michigan, Forenede Stater, 48341
    - Hope Cancer Center
  - Pontiac, Michigan, Forenede Stater, 48341
    - Newland Medical Associates-Pontiac
  - Pontiac, Michigan, Forenede Stater, 48341
    - Trinity Health Saint Joseph Mercy Oakland Hospital
  - Pontiac, Michigan, Forenede Stater, 48341
    - Michigan Healthcare Professionals Pontiac
  - Reed City, Michigan, Forenede Stater, 49677
    - Corewell Health Reed City Hospital
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Corewell Health William Beaumont University Hospital
  - Saginaw, Michigan, Forenede Stater, 48601
    - Ascension Saint Mary's Hospital
  - Saginaw, Michigan, Forenede Stater, 48604
    - Oncology Hematology Associates of Saginaw Valley PC
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Corewell Health Lakeland Hospitals - Saint Joseph Hospital
  - Southfield, Michigan, Forenede Stater, 48075
    - Ascension Providence Hospitals - Southfield
  - Sterling Heights, Michigan, Forenede Stater, 48312
    - Bhadresh Nayak MD PC-Sterling Heights
  - Tawas City, Michigan, Forenede Stater, 48764
    - Ascension Saint Joseph Hospital
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
  - Troy, Michigan, Forenede Stater, 48085
    - Corewell Health Beaumont Troy Hospital
  - Warren, Michigan, Forenede Stater, 48093
    - Saint John Macomb-Oakland Hospital
  - Warren, Michigan, Forenede Stater, 48088
    - Advanced Breast Care Center PLLC
  - Warren, Michigan, Forenede Stater, 48093
    - Great Lakes Cancer Management Specialists-Macomb Professional Building
  - Warren, Michigan, Forenede Stater, 48093
    - Macomb Hematology Oncology PC
  - Warren, Michigan, Forenede Stater, 48093
    - Michigan Breast Specialists-Warren
  - West Branch, Michigan, Forenede Stater, 48661
    - Saint Mary's Oncology/Hematology Associates of West Branch
  - Wyoming, Michigan, Forenede Stater, 49519
    - University of Michigan Health - West
  - Ypsilanti, Michigan, Forenede Stater, 48197
    - Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
  - Ypsilanti, Michigan, Forenede Stater, 48106
    - Huron Gastroenterology PC
- Minnesota
  - Aitkin, Minnesota, Forenede Stater, 56431
    - Riverwood Healthcare Center
  - Bemidji, Minnesota, Forenede Stater, 56601
    - Sanford Joe Lueken Cancer Center
  - Brainerd, Minnesota, Forenede Stater, 56401
    - Essentia Health Saint Joseph's Medical Center
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Minnesota Oncology - Burnsville
  - Cambridge, Minnesota, Forenede Stater, 55008
    - Cambridge Medical Center
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy Hospital
  - Deer River, Minnesota, Forenede Stater, 56636
    - Essentia Health - Deer River Clinic
  - Detroit Lakes, Minnesota, Forenede Stater, 56501
    - Essentia Health Saint Mary's - Detroit Lakes Clinic
  - Duluth, Minnesota, Forenede Stater, 55805
    - Saint Luke's Hospital of Duluth
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview Southdale Hospital
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fosston, Minnesota, Forenede Stater, 56542
    - Essentia Health - Fosston
  - Fridley, Minnesota, Forenede Stater, 55432
    - Unity Hospital
  - Hibbing, Minnesota, Forenede Stater, 55746
    - Essentia Health Hibbing Clinic
  - Maple Grove, Minnesota, Forenede Stater, 55369
    - Fairview Clinics and Surgery Center Maple Grove
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55454
    - Health Partners Inc
  - Monticello, Minnesota, Forenede Stater, 55362
    - Monticello Cancer Center
  - New Ulm, Minnesota, Forenede Stater, 56073
    - New Ulm Medical Center
  - Park Rapids, Minnesota, Forenede Stater, 56470
    - Essentia Health - Park Rapids
  - Princeton, Minnesota, Forenede Stater, 55371
    - Fairview Northland Medical Center
  - Robbinsdale, Minnesota, Forenede Stater, 55422
    - North Memorial Medical Health Center
  - Rochester, Minnesota, Forenede Stater, 55905
    - Mayo Clinic in Rochester
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Coborn Cancer Center at Saint Cloud Hospital
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Sandstone, Minnesota, Forenede Stater, 55072
    - Essentia Health Sandstone
  - Shakopee, Minnesota, Forenede Stater, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Forenede Stater, 55082
    - Lakeview Hospital
  - Thief River Falls, Minnesota, Forenede Stater, 56701
    - Sanford Thief River Falls Medical Center
  - Virginia, Minnesota, Forenede Stater, 55792
    - Essentia Health Virginia Clinic
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forenede Stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Worthington, Minnesota, Forenede Stater, 56187
    - Sanford Cancer Center Worthington
  - Wyoming, Minnesota, Forenede Stater, 55092
    - Fairview Lakes Medical Center
- Mississippi
  - Columbus, Mississippi, Forenede Stater, 39705
    - Baptist Memorial Hospital and Cancer Center-Golden Triangle
  - Grenada, Mississippi, Forenede Stater, 38901
    - Baptist Cancer Center-Grenada
  - Jackson, Mississippi, Forenede Stater, 39216
    - University of Mississippi Medical Center
  - New Albany, Mississippi, Forenede Stater, 38652
    - Baptist Memorial Hospital and Cancer Center-Union County
  - Oxford, Mississippi, Forenede Stater, 38655
    - Baptist Memorial Hospital and Cancer Center-Oxford
  - Southhaven, Mississippi, Forenede Stater, 38671
    - Baptist Memorial Hospital and Cancer Center-Desoto
- Missouri
  - Ballwin, Missouri, Forenede Stater, 63011
    - Saint Louis Cancer and Breast Institute-Ballwin
  - Bolivar, Missouri, Forenede Stater, 65613
    - Central Care Cancer Center - Bolivar
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Southeast Cancer Center
  - Chesterfield, Missouri, Forenede Stater, 63017
    - Saint Luke's Hospital
  - City of Saint Peters, Missouri, Forenede Stater, 63376
    - Siteman Cancer Center at Saint Peters Hospital
  - Columbia, Missouri, Forenede Stater, 65212
    - MU Health - University Hospital/Ellis Fischel Cancer Center
  - Creve Coeur, Missouri, Forenede Stater, 63141
    - Siteman Cancer Center at West County Hospital
  - Farmington, Missouri, Forenede Stater, 63640
    - Parkland Health Center - Farmington
  - Independence, Missouri, Forenede Stater, 64057
    - Centerpoint Medical Center LLC
  - Jefferson City, Missouri, Forenede Stater, 65109
    - MU Health Care Goldschmidt Cancer Center
  - Joplin, Missouri, Forenede Stater, 64804
    - Freeman Health System
  - Joplin, Missouri, Forenede Stater, 64804
    - Mercy Hospital Joplin
  - Kansas City, Missouri, Forenede Stater, 64154
    - University of Kansas Cancer Center - North
  - Kansas City, Missouri, Forenede Stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forenede Stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forenede Stater, 64108
    - University Health Truman Medical Center
  - Lee's Summit, Missouri, Forenede Stater, 64064
    - University of Kansas Cancer Center - Lee's Summit
  - Lee's Summit, Missouri, Forenede Stater, 64086
    - Saint Luke's East - Lee's Summit
  - North Kansas City, Missouri, Forenede Stater, 64116
    - University of Kansas Cancer Center at North Kansas City Hospital
  - Rolla, Missouri, Forenede Stater, 65401
    - Delbert Day Cancer Institute at PCRMC
  - Rolla, Missouri, Forenede Stater, 65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Saint Joseph, Missouri, Forenede Stater, 64506
    - Heartland Regional Medical Center
  - Sainte Genevieve, Missouri, Forenede Stater, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Forenede Stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forenede Stater, 65804
    - Mercy Hospital Springfield
  - St Louis, Missouri, Forenede Stater, 63110
    - Washington University School of Medicine
  - St Louis, Missouri, Forenede Stater, 63129
    - Siteman Cancer Center-South County
  - St Louis, Missouri, Forenede Stater, 63136
    - Siteman Cancer Center at Christian Hospital
  - St Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Medical Center
  - St Louis, Missouri, Forenede Stater, 63141
    - Mercy Hospital Saint Louis
  - St Louis, Missouri, Forenede Stater, 63128
    - Mercy Hospital South
  - St Louis, Missouri, Forenede Stater, 63109
    - Saint Louis Cancer and Breast Institute-South City
  - Sullivan, Missouri, Forenede Stater, 63080
    - Missouri Baptist Sullivan Hospital
  - Sunset Hills, Missouri, Forenede Stater, 63127
    - BJC Outpatient Center at Sunset Hills
  - Washington, Missouri, Forenede Stater, 63090
    - Mercy Hospital Washington
- Montana
  - Anaconda, Montana, Forenede Stater, 59711
    - Community Hospital of Anaconda
  - Billings, Montana, Forenede Stater, 59101
    - Billings Clinic Cancer Center
  - Billings, Montana, Forenede Stater, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Forenede Stater, 59102
    - Saint Vincent Frontier Cancer Center
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Health Deaconess Hospital
  - Butte, Montana, Forenede Stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Forenede Stater, 59405
    - Benefis Sletten Cancer Institute
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Regional Medical Center
  - Missoula, Montana, Forenede Stater, 59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula, Montana, Forenede Stater, 59804
    - Community Medical Center
- Nebraska
  - Bellevue, Nebraska, Forenede Stater, 68123
    - Nebraska Medicine-Bellevue
  - Grand Island, Nebraska, Forenede Stater, 68803
    - Nebraska Cancer Specialists/Oncology Hematology West PC
  - Kearney, Nebraska, Forenede Stater, 68847
    - CHI Health Good Samaritan
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Saint Elizabeth Regional Medical Center
  - Omaha, Nebraska, Forenede Stater, 68114
    - Nebraska Methodist Hospital
  - Omaha, Nebraska, Forenede Stater, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Forenede Stater, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Forenede Stater, 68118
    - Nebraska Medicine-Village Pointe
  - Omaha, Nebraska, Forenede Stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Forenede Stater, 68131
    - Creighton University Medical Center
  - Omaha, Nebraska, Forenede Stater, 68114
    - Oncology Associates PC
  - Omaha, Nebraska, Forenede Stater, 68114
    - Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
  - Papillion, Nebraska, Forenede Stater, 68046
    - Midlands Community Hospital
- Nevada
  - Carson City, Nevada, Forenede Stater, 89703
    - Carson Tahoe Regional Medical Center
  - Henderson, Nevada, Forenede Stater, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - OptumCare Cancer Care at Seven Hills
  - Henderson, Nevada, Forenede Stater, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, Forenede Stater, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, Forenede Stater, 89074
    - GenesisCare USA - Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Comprehensive Cancer Centers of Nevada-Horizon Ridge
  - Henderson, Nevada, Forenede Stater, 89074
    - Las Vegas Urology - Green Valley
  - Henderson, Nevada, Forenede Stater, 89074
    - Las Vegas Urology - Pebble
  - Henderson, Nevada, Forenede Stater, 89074
    - Urology Specialists of Nevada - Green Valley
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Summerlin Hospital Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89109
    - Sunrise Hospital and Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89102
    - OptumCare Cancer Care at Charleston
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, Forenede Stater, 89109
    - GenesisCare USA - Las Vegas
  - Las Vegas, Nevada, Forenede Stater, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, Forenede Stater, 89128
    - OptumCare Cancer Care at MountainView
  - Las Vegas, Nevada, Forenede Stater, 89135
    - Alliance for Childhood Diseases/Cure 4 the Kids Foundation
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Comprehensive Cancer Centers of Nevada - Town Center
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, Forenede Stater, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Forenede Stater, 89148
    - OptumCare Cancer Care at Fort Apache
  - Las Vegas, Nevada, Forenede Stater, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forenede Stater, 89128
    - GenesisCare USA - Vegas Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89148
    - GenesisCare USA - Fort Apache
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Ann M Wierman MD LTD
  - Las Vegas, Nevada, Forenede Stater, 89074
    - Las Vegas Urology - Pecos
  - Las Vegas, Nevada, Forenede Stater, 89102
    - Desert West Surgery
  - Las Vegas, Nevada, Forenede Stater, 89103
    - Hope Cancer Care of Nevada
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Urology Specialists of Nevada - Central
  - Las Vegas, Nevada, Forenede Stater, 89113
    - Las Vegas Prostate Cancer Center
  - Las Vegas, Nevada, Forenede Stater, 89113
    - Las Vegas Urology - Sunset
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Las Vegas Urology - Cathedral Rock
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Las Vegas Urology - Smoke Ranch
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Urology Specialists of Nevada - Northwest
  - Las Vegas, Nevada, Forenede Stater, 89169
    - University Cancer Center
  - Las Vegas, Nevada, Forenede Stater, 89113
    - Urology Specialists of Nevada - Southwest
  - Pahrump, Nevada, Forenede Stater, 89048
    - Hope Cancer Care of Nevada-Pahrump
  - Reno, Nevada, Forenede Stater, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89503
    - Saint Mary's Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89509
    - Radiation Oncology Associates
- New Hampshire
  - Concord, New Hampshire, Forenede Stater, 03301
    - New Hampshire Oncology Hematology PA-Concord
  - Lebanon, New Hampshire, Forenede Stater, 03756
    - Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
  - Manchester, New Hampshire, Forenede Stater, 03103
    - Solinsky Center for Cancer Care
- New Jersey
  - Berkeley Heights, New Jersey, Forenede Stater, 07922
    - Summit Medical Group
  - Camden, New Jersey, Forenede Stater, 08103
    - Cooper Hospital University Medical Center
  - Englewood, New Jersey, Forenede Stater, 07631
    - Englewood Hospital and Medical Center
  - Florham Park, New Jersey, Forenede Stater, 07932
    - Summit Health - Florham Park Campus
  - Hackensack, New Jersey, Forenede Stater, 07601
    - Hackensack University Medical Center
  - Hamilton, New Jersey, Forenede Stater, 08690
    - The Cancer Institute of New Jersey Hamilton
  - Jersey City, New Jersey, Forenede Stater, 07302
    - Jersey City Medical Center
  - Lakewood, New Jersey, Forenede Stater, 08701
    - Monmouth Medical Center Southern Campus
  - Livingston, New Jersey, Forenede Stater, 07039
    - Saint Barnabas Medical Center
  - Long Branch, New Jersey, Forenede Stater, 07740
    - Monmouth Medical Center
  - Morristown, New Jersey, Forenede Stater, 07960
    - Morristown Medical Center
  - New Brunswick, New Jersey, Forenede Stater, 08903
    - Rutgers Cancer Institute of New Jersey
  - Newark, New Jersey, Forenede Stater, 07101
    - Rutgers New Jersey Medical School
  - Newark, New Jersey, Forenede Stater, 07112
    - Newark Beth Israel Medical Center
  - Paterson, New Jersey, Forenede Stater, 07503
    - Saint Joseph's Regional Medical Center
  - Sewell, New Jersey, Forenede Stater, 08080
    - Sidney Kimmel Cancer Center Washington Township
  - Somerville, New Jersey, Forenede Stater, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Summit, New Jersey, Forenede Stater, 07902
    - Overlook Hospital
  - Teaneck, New Jersey, Forenede Stater, 07666
    - Holy Name Hospital
  - Toms River, New Jersey, Forenede Stater, 08755
    - Community Medical Center
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87106
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Forenede Stater, 87110
    - Presbyterian Kaseman Hospital
  - Rio Rancho, New Mexico, Forenede Stater, 87124
    - Presbyterian Rust Medical Center/Jorgensen Cancer Center
- New York
  - Auburn, New York, Forenede Stater, 13021
    - Hematology Oncology Associates of Central New York-Auburn
  - Bay Shore, New York, Forenede Stater, 11706
    - Northwell Health Imbert Cancer Center
  - Buffalo, New York, Forenede Stater, 14263
    - Roswell Park Cancer Institute
  - East Hills, New York, Forenede Stater, 11548
    - The Cancer Institute at Saint Francis Hospital
  - East Syracuse, New York, Forenede Stater, 13057
    - Hematology Oncology Associates of Central New York-East Syracuse
  - Glens Falls, New York, Forenede Stater, 12801
    - Glens Falls Hospital
  - Jamaica, New York, Forenede Stater, 11432
    - Queens Hospital Center
  - Lake Success, New York, Forenede Stater, 11042
    - Northwell Health/Center for Advanced Medicine
  - Mineola, New York, Forenede Stater, 11501
    - NYU Langone Hospital - Long Island
  - Mount Kisco, New York, Forenede Stater, 10549
    - Northern Westchester Hospital
  - New York, New York, Forenede Stater, 10019
    - Mount Sinai West
  - New York, New York, Forenede Stater, 10029
    - Mount Sinai Hospital
  - New York, New York, Forenede Stater, 10032
    - NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
  - New York, New York, Forenede Stater, 10011
    - Mount Sinai Chelsea
  - New York, New York, Forenede Stater, 10016
    - Laura and Isaac Perlmutter Cancer Center at NYU Langone
  - New York, New York, Forenede Stater, 10021
    - Lenox Hill Hospital
  - New York, New York, Forenede Stater, 10065
    - Manhattan Eye Ear and Throat Hospital
  - Nyack, New York, Forenede Stater, 10960
    - Nyack Hospital
  - Poughkeepsie, New York, Forenede Stater, 12601
    - Vassar Brothers Medical Center
  - Rochester, New York, Forenede Stater, 14642
    - University of Rochester
  - Rochester, New York, Forenede Stater, 14623
    - Pluta Cancer Center
  - Sleepy Hollow, New York, Forenede Stater, 10591
    - Phelps Memorial Hospital Center
  - Stony Brook, New York, Forenede Stater, 11794
    - Stony Brook University Medical Center
  - Syracuse, New York, Forenede Stater, 13210
    - State University of New York Upstate Medical University
  - Syracuse, New York, Forenede Stater, 13215
    - Hematology Oncology Associates of Central New York-Onondaga Hill
  - Verona, New York, Forenede Stater, 13478
    - Upstate Cancer Center at Verona
  - West Islip, New York, Forenede Stater, 11795
    - Good Samaritan University Hospital
  - White Plains, New York, Forenede Stater, 10601
    - Dickstein Cancer Treatment Center
- North Carolina
  - Asheboro, North Carolina, Forenede Stater, 27203
    - Randolph Hospital
  - Asheboro, North Carolina, Forenede Stater, 27203
    - Cone Health Cancer Center at Asheboro
  - Asheboro, North Carolina, Forenede Stater, 27203
    - Randolph Health Cancer Center
  - Burlington, North Carolina, Forenede Stater, 27215
    - Cone Health Cancer Center at Alamance Regional
  - Cary, North Carolina, Forenede Stater, 27518
    - Rex Hematology Oncology Associates-Cary
  - Chapel Hill, North Carolina, Forenede Stater, 27599
    - UNC Lineberger Comprehensive Cancer Center
  - Charlotte, North Carolina, Forenede Stater, 28204
    - Novant Health Presbyterian Medical Center
  - Clinton, North Carolina, Forenede Stater, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Durham, North Carolina, Forenede Stater, 27710
    - Duke University Medical Center
  - Garner, North Carolina, Forenede Stater, 27529
    - Rex Hematology Oncology Associates-Garner
  - Gastonia, North Carolina, Forenede Stater, 28054
    - CaroMont Regional Medical Center
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Greensboro, North Carolina, Forenede Stater, 27403
    - Cone Health Cancer Center
  - Greensboro, North Carolina, Forenede Stater, 27410
    - Cone Health Cancer Center at Drawbridge Parkway
  - Greensboro, North Carolina, Forenede Stater, 27403
    - Novant Health Breast Surgery - Greensboro
  - Hillsborough, North Carolina, Forenede Stater, 27278
    - University of North Carolina-Hillsborough Campus
  - Huntersville, North Carolina, Forenede Stater, 28078
    - Novant Health Cancer Institute - Huntersville
  - Jacksonville, North Carolina, Forenede Stater, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Kernersville, North Carolina, Forenede Stater, 27284
    - Novant Health Cancer Institute - Kernersville
  - Kinston, North Carolina, Forenede Stater, 28501
    - ECU Health Oncology Kinston
  - Matthews, North Carolina, Forenede Stater, 28105
    - Matthews Radiation Oncology Center
  - Matthews, North Carolina, Forenede Stater, 28105
    - Novant Health Cancer Institute - Matthews
  - Mebane, North Carolina, Forenede Stater, 27302
    - Cone Heath Cancer Center at Mebane
  - Mooresville, North Carolina, Forenede Stater, 28117
    - Novant Health Cancer Institute - Mooresville
  - Mount Airy, North Carolina, Forenede Stater, 27030
    - Novant Health Cancer Institute - Mount Airy
  - North Wilkesboro, North Carolina, Forenede Stater, 28659
    - Novant Health Cancer Institute - Wilkesboro
  - Pinehurst, North Carolina, Forenede Stater, 28374
    - FirstHealth of the Carolinas-Moore Regional Hospital
  - Raleigh, North Carolina, Forenede Stater, 27607
    - UNC Rex Healthcare
  - Raleigh, North Carolina, Forenede Stater, 27614
    - UNC Rex Cancer Center of Wakefield
  - Raleigh, North Carolina, Forenede Stater, 27607
    - Duke Women's Cancer Care Raleigh
  - Raleigh, North Carolina, Forenede Stater, 27607
    - Rex Hematology Oncology Associates-Blue Ridge
  - Reidsville, North Carolina, Forenede Stater, 27320
    - Annie Penn Memorial Hospital
  - Salisbury, North Carolina, Forenede Stater, 28144
    - Novant Health Cancer Institute - Rowan
  - Statesville, North Carolina, Forenede Stater, 28625
    - Novant Health Cancer Institute - Statesville
  - Thomasville, North Carolina, Forenede Stater, 27360
    - Novant Health Cancer Institute - Thomasville
  - Winston-Salem, North Carolina, Forenede Stater, 27103
    - Novant Health Forsyth Medical Center
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Sanford Bismarck Medical Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Roger Maris Cancer Center
  - Fargo, North Dakota, Forenede Stater, 58103
    - Essentia Health Cancer Center-South University Clinic
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Broadway Medical Center
  - Fargo, North Dakota, Forenede Stater, 58103
    - Sanford South University Medical Center
  - Fargo, North Dakota, Forenede Stater, 58103
    - Southpointe-Sanford Medical Center Fargo
  - Fargo, North Dakota, Forenede Stater, 58104
    - Sanford Medical Center Fargo
  - Jamestown, North Dakota, Forenede Stater, 58401
    - Essentia Health - Jamestown Clinic
- Ohio
  - Alliance, Ohio, Forenede Stater, 44601
    - Aultman Alliance Community Hospital
  - Beavercreek, Ohio, Forenede Stater, 45431
    - Indu and Raj Soin Medical Center
  - Belpre, Ohio, Forenede Stater, 45714
    - Strecker Cancer Center-Belpre
  - Boardman, Ohio, Forenede Stater, 44512
    - Saint Elizabeth Boardman Hospital
  - Canton, Ohio, Forenede Stater, 44708
    - Cleveland Clinic Mercy Hospital
  - Canton, Ohio, Forenede Stater, 44710
    - Aultman Health Foundation
  - Canton, Ohio, Forenede Stater, 44708
    - Mercy Hematology and Oncology Associates Inc
  - Centerville, Ohio, Forenede Stater, 45459
    - Miami Valley Hospital South
  - Centerville, Ohio, Forenede Stater, 45459
    - Dayton Physicians LLC-Miami Valley South
  - Chillicothe, Ohio, Forenede Stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45219
    - The Christ Hospital
  - Cincinnati, Ohio, Forenede Stater, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, Forenede Stater, 45242
    - Bethesda North Hospital
  - Cincinnati, Ohio, Forenede Stater, 45236
    - Oncology Hematology Care Inc-Kenwood
  - Cincinnati, Ohio, Forenede Stater, 45247
    - TriHealth Cancer Institute-Westside
  - Cincinnati, Ohio, Forenede Stater, 45255
    - TriHealth Cancer Institute-Anderson
  - Columbus, Ohio, Forenede Stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forenede Stater, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Forenede Stater, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Forenede Stater, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Forenede Stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forenede Stater, 43213
    - Mount Carmel East Hospital
  - Columbus, Ohio, Forenede Stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel Health Center West
  - Dayton, Ohio, Forenede Stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Miami Valley Hospital North
  - Dayton, Ohio, Forenede Stater, 45415
    - Dayton Physician LLC - Englewood
  - Dayton, Ohio, Forenede Stater, 45409
    - Premier Blood and Cancer Center
  - Delaware, Ohio, Forenede Stater, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Forenede Stater, 43015
    - Grady Memorial Hospital
  - Dublin, Ohio, Forenede Stater, 43016
    - Dublin Methodist Hospital
  - Dublin, Ohio, Forenede Stater, 43016
    - Columbus Oncology and Hematology Associates
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Hospital
  - Findlay, Ohio, Forenede Stater, 45840
    - Armes Family Cancer Center
  - Findlay, Ohio, Forenede Stater, 45840
    - Orion Cancer Care
  - Franklin, Ohio, Forenede Stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Franklin, Ohio, Forenede Stater, 45005
    - Dayton Physicians LLC-Atrium
  - Gahanna, Ohio, Forenede Stater, 43230
    - Central Ohio Breast and Endocrine Surgery
  - Greenville, Ohio, Forenede Stater, 45331
    - Wayne Hospital
  - Greenville, Ohio, Forenede Stater, 45331
    - Dayton Physicians LLC-Wayne
  - Greenville, Ohio, Forenede Stater, 45331
    - Miami Valley Cancer Care and Infusion
  - Grove City, Ohio, Forenede Stater, 43123
    - Mount Carmel Grove City Hospital
  - Kettering, Ohio, Forenede Stater, 45429
    - Kettering Medical Center
  - Kettering, Ohio, Forenede Stater, 45409
    - Greater Dayton Cancer Center
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Forenede Stater, 45801
    - Saint Rita's Medical Center
  - Mansfield, Ohio, Forenede Stater, 44903
    - OhioHealth Mansfield Hospital
  - Marietta, Ohio, Forenede Stater, 45750
    - Marietta Memorial Hospital
  - Marion, Ohio, Forenede Stater, 43302
    - OhioHealth Marion General Hospital
  - Marysville, Ohio, Forenede Stater, 43040
    - Memorial Hospital
  - Mount Vernon, Ohio, Forenede Stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Newark Radiation Oncology
  - Portsmouth, Ohio, Forenede Stater, 45662
    - Southern Ohio Medical Center
  - Springfield, Ohio, Forenede Stater, 45504
    - Springfield Regional Cancer Center
  - Springfield, Ohio, Forenede Stater, 45504
    - Springfield Regional Medical Center
  - Steubenville, Ohio, Forenede Stater, 43952
    - Trinity's Tony Teramana Cancer Center
  - Sylvania, Ohio, Forenede Stater, 43560
    - ProMedica Flower Hospital
  - Toledo, Ohio, Forenede Stater, 43623
    - Mercy Health - Saint Anne Hospital
  - Toledo, Ohio, Forenede Stater, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Toledo, Ohio, Forenede Stater, 43608
    - Mercy Health - Saint Vincent Hospital
  - Troy, Ohio, Forenede Stater, 45373
    - Upper Valley Medical Center
  - Troy, Ohio, Forenede Stater, 45373
    - Dayton Physicians LLC - Troy
  - Warren, Ohio, Forenede Stater, 44484
    - Saint Joseph Warren Hospital
  - Westerville, Ohio, Forenede Stater, 43081
    - Saint Ann's Hospital
  - Youngstown, Ohio, Forenede Stater, 44501
    - Saint Elizabeth Youngstown Hospital
  - Zanesville, Ohio, Forenede Stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Lawton, Oklahoma, Forenede Stater, 73505
    - Cancer Centers of Southwest Oklahoma Research
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Mercy Hospital Oklahoma City
  - Oklahoma City, Oklahoma, Forenede Stater, 73109
    - Integris Southwest Medical Center
  - Oklahoma City, Oklahoma, Forenede Stater, 73142
    - Integris Cancer Institute of Oklahoma
- Oregon
  - Baker City, Oregon, Forenede Stater, 97814
    - Saint Alphonsus Cancer Care Center-Baker City
  - Bend, Oregon, Forenede Stater, 97701
    - Saint Charles Health System
  - Clackamas, Oregon, Forenede Stater, 97015
    - Clackamas Radiation Oncology Center
  - Clackamas, Oregon, Forenede Stater, 97015
    - Providence Cancer Institute Clackamas Clinic
  - Coos Bay, Oregon, Forenede Stater, 97420
    - Bay Area Hospital
  - Gresham, Oregon, Forenede Stater, 97030
    - Legacy Mount Hood Medical Center
  - Newberg, Oregon, Forenede Stater, 97132
    - Providence Newberg Medical Center
  - Ontario, Oregon, Forenede Stater, 97914
    - Saint Alphonsus Cancer Care Center-Ontario
  - Oregon City, Oregon, Forenede Stater, 97045
    - Providence Willamette Falls Medical Center
  - Portland, Oregon, Forenede Stater, 97210
    - Legacy Good Samaritan Hospital and Medical Center
  - Portland, Oregon, Forenede Stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - Providence Saint Vincent Medical Center
  - Redmond, Oregon, Forenede Stater, 97756
    - Saint Charles Health System-Redmond
  - Tualatin, Oregon, Forenede Stater, 97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Allentown, Pennsylvania, Forenede Stater, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Altoona, Pennsylvania, Forenede Stater, 16601
    - UPMC Altoona
  - Beaver, Pennsylvania, Forenede Stater, 15009
    - UPMC-Heritage Valley Health System Beaver
  - Bethlehem, Pennsylvania, Forenede Stater, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Broomall, Pennsylvania, Forenede Stater, 19008
    - Crozer-Keystone Regional Cancer Center at Broomall
  - Bryn Mawr, Pennsylvania, Forenede Stater, 19010
    - Bryn Mawr Hospital
  - Butler, Pennsylvania, Forenede Stater, 16001
    - UPMC Hillman Cancer Center at Butler Health System
  - Camp Hill, Pennsylvania, Forenede Stater, 17011
    - UPMC Camp Hill
  - Carlisle, Pennsylvania, Forenede Stater, 17015
    - Carlisle Regional Cancer Center
  - Chadds Ford, Pennsylvania, Forenede Stater, 19317
    - Christiana Care Health System-Concord Health Center
  - Chambersburg, Pennsylvania, Forenede Stater, 17201
    - Chambersburg Hospital
  - Chambersburg, Pennsylvania, Forenede Stater, 17201
    - WellSpan Medical Oncology and Hematology
  - Collegeville, Pennsylvania, Forenede Stater, 19426
    - Main Line Health Center-Collegeville
  - Cranberry Township, Pennsylvania, Forenede Stater, 16066
    - UPMC Hillman Cancer Center - Passavant - Cranberry
  - Danville, Pennsylvania, Forenede Stater, 17822
    - Geisinger Medical Center
  - Drexel Hill, Pennsylvania, Forenede Stater, 19026
    - Delaware County Memorial Hospital
  - East Norriton, Pennsylvania, Forenede Stater, 19401
    - Fox Chase Cancer Center - East Norriton Hospital Outpatient Center
  - East Stroudsburg, Pennsylvania, Forenede Stater, 18301
    - Pocono Medical Center
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Cancer Center
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Community Hospital
  - Erie, Pennsylvania, Forenede Stater, 16505
    - UPMC Hillman Cancer Center Erie
  - Exton, Pennsylvania, Forenede Stater, 19341
    - Main Line Health Center-Exton
  - Farrell, Pennsylvania, Forenede Stater, 16121
    - UPMC Cancer Center at UPMC Horizon
  - Gettysburg, Pennsylvania, Forenede Stater, 17325
    - Adams Cancer Center
  - Glen Mills, Pennsylvania, Forenede Stater, 19342
    - Crozer Regional Cancer Center at Brinton Lake
  - Greensburg, Pennsylvania, Forenede Stater, 15601
    - UPMC Cancer Centers - Arnold Palmer Pavilion
  - Greenville, Pennsylvania, Forenede Stater, 16125
    - Oncology Hematology Associates
  - Greenville, Pennsylvania, Forenede Stater, 16125
    - UPMC Hillman Cancer Center in Greenville/UPMC Horizon
  - Hanover, Pennsylvania, Forenede Stater, 17331
    - WellSpan Medical Oncology and Hematology
  - Harrisburg, Pennsylvania, Forenede Stater, 17109
    - UPMC Pinnacle Cancer Center/Community Osteopathic Campus
  - Hazleton, Pennsylvania, Forenede Stater, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hazleton, Pennsylvania, Forenede Stater, 18201
    - Lehigh Valley Hospital-Hazleton
  - Hershey, Pennsylvania, Forenede Stater, 17033-0850
    - Penn State Milton S Hershey Medical Center
  - Indiana, Pennsylvania, Forenede Stater, 15701
    - IRMC Cancer Center
  - Johnstown, Pennsylvania, Forenede Stater, 15901
    - UPMC-Johnstown/John P. Murtha Regional Cancer Center
  - Lebanon, Pennsylvania, Forenede Stater, 17042
    - Sechler Family Cancer Center
  - Lewisburg, Pennsylvania, Forenede Stater, 17837
    - Geisinger Medical Oncology-Lewisburg
  - McKeesport, Pennsylvania, Forenede Stater, 15132
    - UPMC Cancer Center at UPMC McKeesport
  - Mechanicsburg, Pennsylvania, Forenede Stater, 17050
    - UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
  - Media, Pennsylvania, Forenede Stater, 19063
    - Riddle Memorial Hospital
  - Monroeville, Pennsylvania, Forenede Stater, 15146
    - UPMC Hillman Cancer Center - Monroeville
  - Moon Township, Pennsylvania, Forenede Stater, 15108
    - UPMC Hillman Cancer Center in Coraopolis
  - Mount Pleasant, Pennsylvania, Forenede Stater, 15666
    - UPMC Hillman Cancer Center - Part of Frick Hospital
  - N. Huntingdon, Pennsylvania, Forenede Stater, 15642
    - Arnold Palmer Cancer Center Medical Oncology Norwin
  - Natrona Heights, Pennsylvania, Forenede Stater, 15065
    - UPMC Cancer Center-Natrona Heights
  - New Castle, Pennsylvania, Forenede Stater, 16105
    - UPMC Hillman Cancer Center - New Castle
  - Paoli, Pennsylvania, Forenede Stater, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19114
    - Jefferson Torresdale Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19104
    - University of Pennsylvania/Abramson Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19140
    - Temple University Hospital
  - Phoenixville, Pennsylvania, Forenede Stater, 19460
    - Phoenixville Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15213
    - UPMC-Magee Womens Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - University of Pittsburgh Cancer Institute (UPCI)
  - Pittsburgh, Pennsylvania, Forenede Stater, 15215
    - UPMC-Saint Margaret
  - Pittsburgh, Pennsylvania, Forenede Stater, 15237
    - UPMC-Passavant Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15243
    - UPMC-Saint Clair Hospital Cancer Center
  - Pittsburgh, Pennsylvania, Forenede Stater, 15219
    - UPMC-Mercy Hospital
  - Pottstown, Pennsylvania, Forenede Stater, 19464
    - Pottstown Hospital
  - Pottsville, Pennsylvania, Forenede Stater, 17901
    - Geisinger Cancer Services-Pottsville
  - Sayre, Pennsylvania, Forenede Stater, 18840
    - Guthrie Medical Group PC-Robert Packer Hospital
  - Scranton, Pennsylvania, Forenede Stater, 18510
    - Community Medical Center
  - Seneca, Pennsylvania, Forenede Stater, 16346
    - UPMC Cancer Center at UPMC Northwest
  - Uniontown, Pennsylvania, Forenede Stater, 15401
    - UPMC Cancer Center-Uniontown
  - Upland, Pennsylvania, Forenede Stater, 19013
    - Crozer-Chester Medical Center
  - Washington, Pennsylvania, Forenede Stater, 15301
    - UPMC Cancer Center-Washington
  - West Mifflin, Pennsylvania, Forenede Stater, 15122
    - UPMC West Mifflin-Cancer Center Jefferson
  - West Reading, Pennsylvania, Forenede Stater, 19611
    - Reading Hospital
  - Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Williamsport, Pennsylvania, Forenede Stater, 17701
    - UPMC Susquehanna
  - Williamsport, Pennsylvania, Forenede Stater, 17754
    - Divine Providence Hospital
  - Willow Grove, Pennsylvania, Forenede Stater, 19090
    - Asplundh Cancer Pavilion
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Lankenau Medical Center
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Cancer Center
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Hospital
  - York, Pennsylvania, Forenede Stater, 17403
    - Cancer Care Associates of York
  - York, Pennsylvania, Forenede Stater, 17408
    - UPMC Memorial
- Rhode Island
  - Providence, Rhode Island, Forenede Stater, 02903
    - Rhode Island Hospital
  - Providence, Rhode Island, Forenede Stater, 02905
    - Women and Infants Hospital
  - Warwick, Rhode Island, Forenede Stater, 02886
    - Kent Hospital
- South Carolina
  - Beaufort, South Carolina, Forenede Stater, 29902
    - Beaufort Memorial Hospital
  - Bluffton, South Carolina, Forenede Stater, 29910
    - Saint Joseph's/Candler - Bluffton Campus
  - Boiling Springs, South Carolina, Forenede Stater, 29316
    - Prisma Health Cancer Institute - Spartanburg
  - Charleston, South Carolina, Forenede Stater, 29425
    - Medical University of South Carolina
  - Easley, South Carolina, Forenede Stater, 29640
    - Prisma Health Cancer Institute - Easley
  - Florence, South Carolina, Forenede Stater, 29506
    - McLeod Regional Medical Center
  - Gaffney, South Carolina, Forenede Stater, 29341
    - Gibbs Cancer Center-Gaffney
  - Georgetown, South Carolina, Forenede Stater, 29440
    - Tidelands Georgetown Memorial Hospital
  - Greenville, South Carolina, Forenede Stater, 29605
    - Prisma Health Cancer Institute - Faris
  - Greenville, South Carolina, Forenede Stater, 29607
    - Saint Francis Cancer Center
  - Greenville, South Carolina, Forenede Stater, 29615
    - Prisma Health Cancer Institute - Eastside
  - Greenville, South Carolina, Forenede Stater, 29605
    - Prisma Health Cancer Institute - Butternut
  - Greenville, South Carolina, Forenede Stater, 29601
    - Saint Francis Hospital
  - Greenville, South Carolina, Forenede Stater, 29605
    - Prisma Health Greenville Memorial Hospital
  - Greer, South Carolina, Forenede Stater, 29650
    - Prisma Health Cancer Institute - Greer
  - Greer, South Carolina, Forenede Stater, 29651
    - Gibbs Cancer Center-Pelham
  - Hilton Head Island, South Carolina, Forenede Stater, 29926-3827
    - South Carolina Cancer Specialists PC
  - Seneca, South Carolina, Forenede Stater, 29672
    - Prisma Health Cancer Institute - Seneca
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Spartanburg Medical Center
  - Union, South Carolina, Forenede Stater, 29379
    - MGC Hematology Oncology-Union
  - West Columbia, South Carolina, Forenede Stater, 29169
    - Lexington Medical Center
- South Dakota
  - Aberdeen, South Dakota, Forenede Stater, 57401
    - Avera Cancer Institute-Aberdeen
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sanford Cancer Center Oncology Clinic
  - Yankton, South Dakota, Forenede Stater, 57078
    - Avera Cancer Institute at Yankton
- Tennessee
  - Alcoa, Tennessee, Forenede Stater, 37701
    - University Cancer Specialists - Alcoa
  - Collierville, Tennessee, Forenede Stater, 38017
    - Baptist Memorial Hospital and Cancer Center-Collierville
  - Cookeville, Tennessee, Forenede Stater, 38501
    - Cookeville Regional Medical Center
  - Franklin, Tennessee, Forenede Stater, 37067
    - Vanderbilt-Ingram Cancer Center Cool Springs
  - Kingsport, Tennessee, Forenede Stater, 37660
    - Ballad Health Cancer Care - Kingsport
  - Knoxville, Tennessee, Forenede Stater, 37920
    - University of Tennessee - Knoxville
  - Memphis, Tennessee, Forenede Stater, 38120
    - Baptist Memorial Hospital and Cancer Center-Memphis
  - Nashville, Tennessee, Forenede Stater, 37232
    - Vanderbilt University/Ingram Cancer Center
  - Nashville, Tennessee, Forenede Stater, 37204
    - Vanderbilt Breast Center at One Hundred Oaks
- Texas
  - Amarillo, Texas, Forenede Stater, 79106
    - The Don and Sybil Harrington Cancer Center
  - Baytown, Texas, Forenede Stater, 77521
    - Houston Methodist San Jacinto Hospital
  - Bryan, Texas, Forenede Stater, 77802
    - Saint Joseph Regional Cancer Center
  - Conroe, Texas, Forenede Stater, 77384
    - MD Anderson in The Woodlands
  - Dallas, Texas, Forenede Stater, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, Forenede Stater, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - Dallas, Texas, Forenede Stater, 75237
    - UT Southwestern Simmons Cancer Center - RedBird
  - Fort Worth, Texas, Forenede Stater, 76104
    - UT Southwestern/Simmons Cancer Center-Fort Worth
  - Galveston, Texas, Forenede Stater, 77555-0565
    - University of Texas Medical Branch
  - Houston, Texas, Forenede Stater, 77030
    - M D Anderson Cancer Center
  - Houston, Texas, Forenede Stater, 77026-1967
    - Lyndon Baines Johnson General Hospital
  - Houston, Texas, Forenede Stater, 77030
    - Houston Methodist Hospital
  - Houston, Texas, Forenede Stater, 77030
    - Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
  - Houston, Texas, Forenede Stater, 77070
    - Methodist Willowbrook Hospital
  - Houston, Texas, Forenede Stater, 77030
    - Ben Taub General Hospital
  - Houston, Texas, Forenede Stater, 77094
    - Houston Methodist West Hospital
  - Houston, Texas, Forenede Stater, 77079
    - MD Anderson West Houston
  - Laredo, Texas, Forenede Stater, 78041
    - Doctor's Hospital of Laredo
  - League City, Texas, Forenede Stater, 77573
    - MD Anderson League City
  - Lubbock, Texas, Forenede Stater, 79415
    - UMC Cancer Center / UMC Health System
  - Nassau Bay, Texas, Forenede Stater, 77058
    - Houston Methodist Saint John Hospital
  - Richardson, Texas, Forenede Stater, 75080
    - UT Southwestern Clinical Center at Richardson/Plano
  - Sugar Land, Texas, Forenede Stater, 77478
    - MD Anderson in Sugar Land
  - Sugar Land, Texas, Forenede Stater, 77479
    - Houston Methodist Sugar Land Hospital
  - The Woodlands, Texas, Forenede Stater, 77385
    - Houston Methodist The Woodlands Hospital
- Virginia
  - Bristol, Virginia, Forenede Stater, 24201
    - Wellmont Medical Associates-Bristol
  - Burke, Virginia, Forenede Stater, 22015
    - Kaiser Permanente-Burke Medical Center
  - Chesapeake, Virginia, Forenede Stater, 23320
    - Cancer Specialists of Tidewater Limited
  - Fairfax, Virginia, Forenede Stater, 22031
    - Inova Schar Cancer Institute
  - Fairfax, Virginia, Forenede Stater, 22033
    - Inova Fair Oaks Hospital
  - Gloucester, Virginia, Forenede Stater, 23061
    - Peninsula Cancer Institute-Gloucester
  - Lynchburg, Virginia, Forenede Stater, 24501
    - Centra Alan B Pearson Regional Cancer Center
  - McLean, Virginia, Forenede Stater, 22102
    - Kaiser Permanente Tysons Corner Medical Center
  - Mechanicsville, Virginia, Forenede Stater, 23116
    - Bon Secours Memorial Regional Medical Center
  - Midlothian, Virginia, Forenede Stater, 23114
    - Bon Secours Saint Francis Medical Center
  - Midlothian, Virginia, Forenede Stater, 23113
    - Bon Secours Westchester Emergency Center
  - Newport News, Virginia, Forenede Stater, 23601
    - Peninsula Cancer Institute-Newport News
  - Norfolk, Virginia, Forenede Stater, 23505
    - Bon Secours DePaul Medical Center
  - Portsmouth, Virginia, Forenede Stater, 23707
    - Bon Secours Maryview Medical Center
  - Richmond, Virginia, Forenede Stater, 23235
    - VCU Massey Cancer Center at Stony Point
  - Richmond, Virginia, Forenede Stater, 23298
    - Virginia Commonwealth University/Massey Cancer Center
  - Richmond, Virginia, Forenede Stater, 23229
    - Virginia Cancer Institute
  - Richmond, Virginia, Forenede Stater, 23226
    - Bon Secours Saint Mary's Hospital
  - Richmond, Virginia, Forenede Stater, 23230
    - Bon Secours Cancer Institute at Reynolds Crossing
  - South Hill, Virginia, Forenede Stater, 23970
    - VCU Community Memorial Health Center
  - Suffolk, Virginia, Forenede Stater, 23435
    - Cancer Specialists of Tidewater-Suffolk
  - Suffolk, Virginia, Forenede Stater, 23435
    - Bon Secours Health Center at Harbour View
  - Virginia Beach, Virginia, Forenede Stater, 23454
    - Peninsula Cancer Institute-Cancer Specialists of Tidewater
  - Williamsburg, Virginia, Forenede Stater, 23185
    - Peninsula Cancer Institute-Williamsburg
  - Woodbridge, Virginia, Forenede Stater, 22192
    - Kaiser Permanente-Caton Hill Medical Center
- Washington
  - Aberdeen, Washington, Forenede Stater, 98520
    - Providence Regional Cancer System-Aberdeen
  - Auburn, Washington, Forenede Stater, 98001
    - MultiCare Auburn Medical Center
  - Bellevue, Washington, Forenede Stater, 98004
    - Overlake Medical Center
  - Bellingham, Washington, Forenede Stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Bremerton, Washington, Forenede Stater, 98310
    - Harrison HealthPartners Hematology and Oncology-Bremerton
  - Burien, Washington, Forenede Stater, 98166
    - Highline Medical Center-Main Campus
  - Centralia, Washington, Forenede Stater, 98531
    - Providence Regional Cancer System-Centralia
  - Edmonds, Washington, Forenede Stater, 98026
    - Swedish Cancer Institute-Edmonds
  - Enumclaw, Washington, Forenede Stater, 98022
    - Saint Elizabeth Hospital
  - Everett, Washington, Forenede Stater, 98201
    - Providence Regional Cancer Partnership
  - Federal Way, Washington, Forenede Stater, 98003
    - Saint Francis Hospital
  - Gig Harbor, Washington, Forenede Stater, 98335
    - MultiCare Gig Harbor Medical Park
  - Issaquah, Washington, Forenede Stater, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Forenede Stater, 99336
    - Kadlec Clinic Hematology and Oncology
  - Lacey, Washington, Forenede Stater, 98503
    - Providence Regional Cancer System-Lacey
  - Lakewood, Washington, Forenede Stater, 98499
    - Saint Clare Hospital
  - Longview, Washington, Forenede Stater, 98632
    - PeaceHealth Saint John Medical Center
  - Port Townsend, Washington, Forenede Stater, 98368
    - Jefferson Healthcare
  - Poulsbo, Washington, Forenede Stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Puyallup, Washington, Forenede Stater, 98372
    - MultiCare Good Samaritan Hospital
  - Renton, Washington, Forenede Stater, 98055
    - Valley Medical Center
  - Seattle, Washington, Forenede Stater, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Forenede Stater, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forenede Stater, 98104
    - Pacific Gynecology Specialists
  - Seattle, Washington, Forenede Stater, 98122-5711
    - Swedish Medical Center-Cherry Hill
  - Sedro-Woolley, Washington, Forenede Stater, 98284
    - PeaceHealth United General Medical Center
  - Shelton, Washington, Forenede Stater, 98584
    - Providence Regional Cancer System-Shelton
  - Silverdale, Washington, Forenede Stater, 98383
    - Saint Michael Cancer Center
  - Spokane, Washington, Forenede Stater, 99204
    - MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
  - Spokane, Washington, Forenede Stater, 99218
    - MultiCare Deaconess Cancer and Blood Specialty Center - North
  - Tacoma, Washington, Forenede Stater, 98405
    - Northwest Medical Specialties PLLC
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Tacoma General Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - Franciscan Research Center-Northwest Medical Plaza
  - Vancouver, Washington, Forenede Stater, 98686
    - Legacy Salmon Creek Hospital
  - Vancouver, Washington, Forenede Stater, 98664
    - PeaceHealth Southwest Medical Center
  - Vancouver, Washington, Forenede Stater, 98684
    - Legacy Cancer Institute Medical Oncology and Day Treatment
  - Walla Walla, Washington, Forenede Stater, 99362
    - Providence Saint Mary Regional Cancer Center
  - Yakima, Washington, Forenede Stater, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
  - Yelm, Washington, Forenede Stater, 98597
    - Providence Regional Cancer System-Yelm
- West Virginia
  - Charleston, West Virginia, Forenede Stater, 25304
    - West Virginia University Charleston Division
  - Huntington, West Virginia, Forenede Stater, 25701
    - Edwards Comprehensive Cancer Center
- Wisconsin
  - Antigo, Wisconsin, Forenede Stater, 54409
    - Langlade Hospital and Cancer Center
  - Appleton, Wisconsin, Forenede Stater, 54911
    - ThedaCare Regional Cancer Center
  - Appleton, Wisconsin, Forenede Stater, 54915
    - Ascension Saint Elizabeth Hospital
  - Ashland, Wisconsin, Forenede Stater, 54806
    - Duluth Clinic Ashland
  - Ashland, Wisconsin, Forenede Stater, 54806
    - Northwest Wisconsin Cancer Center
  - Brookfield, Wisconsin, Forenede Stater, 53045
    - Ascension Southeast Wisconsin Hospital - Elmbrook Campus
  - Burlington, Wisconsin, Forenede Stater, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Chilton, Wisconsin, Forenede Stater, 53014
    - Ascension Calumet Hospital
  - Cudahy, Wisconsin, Forenede Stater, 53110
    - Aurora Saint Luke's South Shore
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Medical Center-EC Cancer Center
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - HSHS Sacred Heart Hospital
  - Franklin, Wisconsin, Forenede Stater, 53132
    - Ascension Saint Francis - Reiman Cancer Center
  - Franklin, Wisconsin, Forenede Stater, 53132
    - Ascension Southeast Wisconsin Hospital - Franklin
  - Germantown, Wisconsin, Forenede Stater, 53022
    - Aurora Health Care Germantown Health Center
  - Grafton, Wisconsin, Forenede Stater, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Forenede Stater, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Forenede Stater, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Janesville, Wisconsin, Forenede Stater, 53548
    - Mercyhealth Hospital and Cancer Center - Janesville
  - Johnson Creek, Wisconsin, Forenede Stater, 53038
    - University of Wisconsin Carbone Cancer Center - Johnson Creek
  - Kenosha, Wisconsin, Forenede Stater, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Medical Center
  - Madison, Wisconsin, Forenede Stater, 53792
    - University of Wisconsin Carbone Cancer Center - University Hospital
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Medical Center-Marshfield
  - Medford, Wisconsin, Forenede Stater, 54451
    - Aspirus Medford Hospital
  - Menomonee Falls, Wisconsin, Forenede Stater, 53051
    - Froedtert Menomonee Falls Hospital
  - Mequon, Wisconsin, Forenede Stater, 53097
    - Ascension Columbia Saint Mary's Hospital Ozaukee
  - Milwaukee, Wisconsin, Forenede Stater, 53226
    - Medical College of Wisconsin
  - Milwaukee, Wisconsin, Forenede Stater, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53233
    - Aurora Sinai Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53210
    - Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
  - Milwaukee, Wisconsin, Forenede Stater, 53211
    - Ascension Columbia Saint Mary's Hospital - Milwaukee
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Ascension Saint Francis Hospital
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Clinic-Minocqua Center
  - Mukwonago, Wisconsin, Forenede Stater, 53149
    - ProHealth D N Greenwald Center
  - Neenah, Wisconsin, Forenede Stater, 54956
    - ThedaCare Regional Medical Center - Neenah
  - New Richmond, Wisconsin, Forenede Stater, 54017
    - Cancer Center of Western Wisconsin
  - Oak Creek, Wisconsin, Forenede Stater, 53154
    - Drexel Town Square Health Center
  - Oconomowoc, Wisconsin, Forenede Stater, 53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oconto Falls, Wisconsin, Forenede Stater, 54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Oshkosh, Wisconsin, Forenede Stater, 54904
    - Ascension Mercy Hospital
  - Oshkosh, Wisconsin, Forenede Stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forenede Stater, 53406
    - Aurora Cancer Care-Racine
  - Racine, Wisconsin, Forenede Stater, 53405
    - Ascension All Saints Hospital
  - Rhinelander, Wisconsin, Forenede Stater, 54501
    - Ascension Saint Mary's Hospital
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Medical Center-Rice Lake
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Ascension Saint Michael's Hospital
  - Stevens Point, Wisconsin, Forenede Stater, 54482
    - Marshfield Medical Center-River Region at Stevens Point
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
    - Saint Vincent Hospital Cancer Center at Sturgeon Bay
  - Summit, Wisconsin, Forenede Stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forenede Stater, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - UW Cancer Center at ProHealth Care
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - ProHealth Waukesha Memorial Hospital
  - Waupaca, Wisconsin, Forenede Stater, 54981
    - ThedaCare Cancer Care - Waupaca
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Aspirus Regional Cancer Center
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Ascension Medical Group Southeast Wisconsin - Mayfair Road
  - West Allis, Wisconsin, Forenede Stater, 53227
    - Aurora West Allis Medical Center
  - West Bend, Wisconsin, Forenede Stater, 53095
    - Froedtert West Bend Hospital/Kraemer Cancer Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Medical Center - Weston
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Aspirus Cancer Care - Wisconsin Rapids
- Wyoming
  - Cheyenne, Wyoming, Forenede Stater, 82001
    - Cheyenne Regional Medical Center-West
  - Cody, Wyoming, Forenede Stater, 82414
    - Billings Clinic-Cody
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center
Puerto Rico
- - Bayamón, Puerto Rico, 00959-5060
    - Cancer Center-Metro Medical Center Bayamon
  - Bayamón, Puerto Rico, 00961
    - Puerto Rico Hematology Oncology Group
  - Manatí, Puerto Rico, 00674
    - Doctors Cancer Center
  - San Juan, Puerto Rico, 00917
    - San Juan Community Oncology Group
  - San Juan, Puerto Rico, 00927
    - Centro Comprensivo de Cancer de UPR
  - San Juan, Puerto Rico, 00936
    - San Juan City Hospital
  - San Juan, Puerto Rico, 00927
    - PROncology

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

HER2-positiv status vil være baseret på biopsimateriale før behandling og defineret som en immunhistokemi (IHC) score på 3+ og/eller positiv ved in situ hybridisering (ISH) ifølge det nuværende American Society of Clinical Oncology (ASCO) College of American Pathologists ( CAP) retningslinjer. Central test er ikke påkrævet
* Kendt hormonreceptor (HR) status som defineret af ASCO/CAP retningslinjer (baseret på forbehandlingsbiopsimateriale). Hormonreceptor positiv status kan bestemmes af enten kendt positiv østrogenreceptor (ER) eller kendt positiv progesteronreceptor (PR) status; hormonreceptor negativ status skal bestemmes af både kendt negativ ER og kendt negativ PR
Patienter med klinisk stadium T1-4, N0-3 sygdom ved præsentation og resterende invasiv sygdom postoperativt som defineret ovenfor er kvalificerede. (Bemærk: Patienter med T1a/bN0-tumorer er ikke kvalificerede ved indledende brystkræftdiagnose er ikke kvalificerede)
Patienter med resterende HR-negativ, HER2 positiv (+) sygdom i brystet og/eller lymfeknuderne i henhold til den kirurgiske patologirapport er kvalificerede; dog skal patienter med HR+ HER2+ cancere have nodepositiv restsygdom ifølge den kirurgiske patologirapport for at kvalificere sig til undersøgelsen. Tilstedeværelsen af resterende invasiv sygdom i brystet er ikke obligatorisk for disse patienter
Patienter med svagt ER-positiv (1-10 %) brystkræft (baseret på forbehandlingens kernebiopsi) er berettigede, selvom de har node-negativ sygdom ifølge den kirurgiske patologirapport
Det resterende sygdomsvæv (bryst- og/eller lymfeknuder) kræves ikke for at være HER2-positivt, da berettigelse til NCI-2020-03770 (A011801) er baseret på en positiv HER2-status på tidspunktet for den første brystkræftdiagnose
* Bemærk: Tilstedeværelsen af mikrometastaser i lymfeknuder efter præoperativ terapi tæller som resterende sygdom, hvorimod tilstedeværelsen af isolerede tumorceller ikke
Patienter med synkron bilateral invasiv sygdom er kvalificerede, forudsat at begge læsioner blev bekræftet som HER2-positive, og mindst én af læsionerne opfylder kriterierne skitseret ovenfor. Multifokal sygdom er tilladt, så længe den største biopsiede brysttumor var HER2-positiv
Patienterne skal have modtaget neoadjuverende kemoterapi med et af følgende regimer: docetaxel/trastuzumab/pertuzumab (THP), paclitaxel/methotrexat/cisplatin (TMP), doxorubicin/cyclophosphamid/paclitaxel/trastuzumab/pertuzumab (AC-TH(P)); docetaxel/carboplatin/trastuzumab/pertuzumab (TCH(P)); fluorouracil/doxorubicin/cyclophosphamid-docetaxel/trastuzumab/pertuzumab (FAC-TH(P)), eller fluorouracil/epirubicin/cyclophosphamid-docetaxel/trastuzumab/pertuzumab (FEC-TH(P)). Bemærk: bortset fra TCHP, hvor T er docetaxel, er behandling med docetaxel eller paclitaxel acceptabel
Forudgående modtagelse af T-DM1 i neoadjuverende omgivelser er ikke tilladt.
- Tidligere behandling skal have bestået af >= 6 cyklusser af kemoterapi og HER2-styret behandling med en samlet varighed på >= 12 uger, inklusive mindst 9 ugers præoperativ taxan og trastuzumab med eller uden pertuzumab (eller Food and Drug Administration [FDA] ]-godkendte biosimilars). Patienter, der har modtaget mindst 9 ugers præoperativ taxan, pertuzumab og margetuximab, er også kvalificerede, hvis de modtog >= 6 cyklusser af systemisk terapi før indskrivning. Bemærk: Patienter, der fuldfører mindst ni af de planlagte tolv doser af ugentlige paclitaxel eller tre ud af de planlagte fire doser af docetaxel, men afbrydes for tidligt på grund af toksicitet, er kvalificerede. Patienter, der får dosistætte kemoterapiregimer, er også kvalificerede. Forudgående brug af nab-paclitaxel (Abraxane) i stedet for paclitaxel eller docetaxel er tilladt. Forudgående brug af subkutan trastuzumab (Hylecta) og subkutan trastuzumab og pertuzumab (Phesgo) er også tilladt.
- Patienter, der modtog neoadjuverende systemisk behandling, som inkluderede eksperimentel HER2-målrettet behandling/terapier, er potentielt kvalificerede, så længe forsøgsmidlet ikke var et HER2-målrettet antistof-lægemiddelkonjugat (f. T-DM1, DS-8201a [trastuzumab deruxtecan]) eller en HER2-målrettet tyrosinkinasehæmmer (TKI) (f.eks. tucatinib, lapatinib, neratinib).
Patienter kan have modtaget =< 1 cyklus af T-DM1 i adjuverende indstilling. Bemærk: Disse patienter vil blive randomiseret til at modtage yderligere 14 cyklusser af T-DM1 og tucatinib/placebo som tolereret. Den seneste cyklus af T-DM1 skulle have været administreret =< 5 uger før registrering
* Bemærk: Begge følgende to kriterier skal være opfyldt, for at patienten er kvalificeret til denne undersøgelse
- Et interval på ikke mere end 12 uger mellem afslutningsdatoen for den sidste endelige behandling (f. postoperativ kemoterapi eller stråling, eller, hvis ingen af dem er givet, brystkirurgisk dato) og registreringsdatoen. Samtidig strålebehandling er tilladt, mens du modtager studiebehandling
- Patienter skal registreres i undersøgelsen inden for =< 180 dage efter datoen for den seneste endelige brystkræftoperation (ikke inklusive rekonstruktiv kirurgi)
Al systemisk kemoterapi skulle være afsluttet præoperativt, medmindre deltagelse i EA1181 (CompassHER2 patologisk komplet respons [pCR]) eller BIG DECRESCENDO Trial (som er meget lig CompassHER2 pCR med hensyn til undersøgelsesdesign, lægemidler og egnethed). Patienter, der modtog 4 cyklusser af neoadjuverende THP off-studie, kan dog modtage yderligere 2-4 cyklusser kemoterapi postoperativt for at opfylde berettigelsen til A011801. Patienter, der deltog i EA1181 eller MA41 og fortsatte til operation umiddelbart efter det deeskalerede forsøgsregime, skal modtage postoperativ kemoterapi for at fuldføre i alt >= 6 cyklusser af systemisk behandling før tilmelding til A011801, som skitseret ovenfor (f.eks. 4 cyklusser før- operationelt og 2 cyklusser postoperativt). Den ordinerede postoperative kemoterapi-kur er efter den behandlende onkologs skøn (dvs. 2-4 cyklusser AC eller THP, andet). Fortsættelse af trastuzumab + pertuzumab (HP) præ- eller postoperativt som vedligeholdelsesterapi (i afventning af en operationsdato eller en officiel patologirapport) er tilladt for alle undersøgelsesdeltagere
Toksiciteter relateret til tidligere systemisk behandling bør være forsvundet eller være ved baseline, bortset fra alopeci og perifer neuropati =< grad 1
Tilstrækkelig excision: kirurgisk fjernelse af al klinisk tydelig sygdom i brystet og lymfeknuderne som følger:
- Brystoperation: total mastektomi uden grov resterende sygdom ved resektionsmarginen eller brystbevarende operation med histologisk negative udskæringsmargener
- For patienter, der gennemgår brystbevarende kirurgi, skal marginerne af den resekerede prøve være histologisk fri for invasiv tumor og ductal carcinoma in situ (DCIS) som bestemt af den lokale patolog. Hvis patologisk undersøgelse viser tumor ved resektionslinjen, kan yderligere operative procedurer udføres for at opnå klare marginer. Hvis tumor stadig er til stede ved den resekerede margin efter re-excision(er), skal patienten gennemgå total mastektomi for at være berettiget. Patienter med marginer positive for klassisk lobulært karcinom in situ (LCIS) er kvalificerede uden yderligere resektion
- Lymfeknudeoperation ** Aksillen skal evalueres med enten vagtkirtelbiopsi eller aksillær lymfeknudedissektion. Hvis patienter har en vagtpostlymfeknudebiopsi, og vagtkirtlen er negative, er yderligere aksillær behandling ikke nødvendig. Hvis patienter har isolerede tumorceller (ITC'er) i forbindelse med resterende brystsygdom, kræves mindst én af følgende: aksillær lymfeknudedissektion (ALND) eller planlagt nodal bestråling. Hvis patienter har mikro- eller makrometastatisk nodalsygdom, er ALND og planlagt nodal bestråling påkrævet. Bemærk, at medtilmelding på Alliance A011202 ikke er tilladt
Eastern Cooperative Oncology Group (ECOG) præstationsstatus 0-1
Absolut neutrofiltal (ANC) >= 1.000/mm^3
Hæmoglobin >= 8 g/dL (Bemærk: Transfusion med pakkede røde blodlegemer [PRBC] er ikke tilladt for at opnå berettigelse)
Blodpladetal >= 100.000/mm^3
Kreatinin =< 1,5 x øvre normalgrænse (ULN)
Total bilirubin =< 1,0 x øvre normalgrænse (ULN) eller direkte bilirubin inden for det institutionelle normalområde for patienter med Gilberts syndrom
Aspartataminotransferase (AST)/alaninaminotransferase (ALT) =< 2,5 x øvre normalgrænse (ULN)
Screening af venstre ventrikulær ejektionsfraktion (LVEF) >= 50 % på ekkokardiogram (ECHO) eller multiple-gated acquisition (MUGA) efter modtagelse af neoadjuverende kemoterapi og intet fald i LVEF med mere end 15 % absolutte procentpoint fra prækemoterapi LVEF. Eller, hvis prækemoterapi-LVEF ikke blev vurderet, skal screenings-LVEF være >= 55 % efter afslutning af neoadjuverende kemoterapi. Bemærk: LVEF-vurdering kan gentages en gang i op til 3 uger efter den indledende screeningsvurdering for at vurdere berettigelse

Ekskluderingskriterier:

Ingen adjuverende behandling med noget anti-cancer forsøgslægemiddel inden for 28 dage før registrering
Ikke gravid og ikke ammende, fordi denne undersøgelse involverer et middel, der har kendt genotoksiske, mutagene og teratogene virkninger. Derfor, kun for kvinder i den fødedygtige alder, er en negativ serumgraviditetstest udført =< 7 dage før registrering påkrævet
Patienter med kendt aktiv og/eller ubehandlet hepatitis B eller hepatitis C eller kronisk leversygdom er ikke kvalificerede. Patienter med en diagnose af hepatitis B eller C, der er blevet behandlet og udbedret og normal leverfunktion er berettiget til at deltage i undersøgelsen, hvis de andre berettigelsesparametre er opfyldt
Stadie IV (metastatisk) brystkræft
Anamnese med tidligere (ipsi- eller kontralateral) invasiv brystkræft inden for 3 år efter registrering
Patienter med ER+ HER2+ resterende invasiv sygdom, der er lymfeknude-negativ ifølge den kirurgiske patologirapport
Evidens for tilbagevendende sygdom efter præoperativ terapi og kirurgi
Patienter, for hvem strålebehandling vil blive anbefalet til brystkræftbehandling, men for hvem det er kontraindiceret på grund af medicinske årsager (f.eks. bindevævsforstyrrelser eller tidligere ipsilateral bryststråling)
Anamnese med eksponering for følgende kumulative doser af antracykliner: doxorubicin > 240 mg/m^2; epirubicin eller liposomalt doxorubicin-hydrochlorid (Myocet) > 480 mg/m^2. For andre antracykliner, eksponering svarende til doxorubicin > 240 mg/m^2
Kardiopulmonal dysfunktion som defineret ved et af følgende:
- Historien om National Cancer Institute (NCI) CTCAE version (v) 5.0 grad >= 3 symptomatisk kongestiv hjerteinsufficiens (CHF) eller New York Heart Association (NYHA) kriterier klasse >= II
- Angina pectoris, der kræver anti-anginal medicin, alvorlig hjertearytmi, der ikke kontrolleres af tilstrækkelig medicin, alvorlig ledningsabnormitet eller klinisk signifikant klapsygdom
- Ukontrollerede arytmier med høj risiko: dvs. atriel takykardi med en hjertefrekvens > 100/min i hvile, signifikant ventrikulær arytmi (ventrikulær takykardi) eller højere grad af atrioventrikulær blok (AV)-blok (anden grads AV-blok type 2 [Mobitz 2) ] eller tredje grads AV-blok)
- Signifikante symptomer (grad >= 2) relateret til venstre ventrikulær dysfunktion, hjertearytmi eller hjerteiskæmi, mens eller siden du har modtaget præoperativ behandling
- Anamnese med et fald i venstre ventrikulær ejektionsfraktion (LVEF) til < 40 % med tidligere trastuzumab-behandling (f.eks. under præoperativ behandling)
- Ukontrolleret hypertension (systolisk blodtryk > 180 mmHg og/eller diastolisk blodtryk > 100 mmHg)
Aktuel alvorlig, ukontrolleret systemisk sygdom
Større kirurgisk indgreb, der ikke er relateret til brystkræft eller betydelig traumatisk skade inden for 28 dage før registrering eller forventning om behovet for større operation under studiebehandlingsforløbet
Anamnese med intolerance, inklusive grad 3 til 4 infusionsreaktion eller overfølsomhed over for trastuzumab eller murine proteiner eller nogen af produktets komponenter
Perifer neuropati af enhver ætiologi, der overstiger grad 1
Efterforskerens vurdering som værende ude af stand til eller uvillig til at overholde kravene i protokollen
Brug af en stærk CYP3A4- eller CYP2C8-hæmmer inden for 2 uger eller brug af en stærk CYP3A4- eller CYP2C8-inducer inden for 5 dage før registrering er forbudt.
- Bemærk venligst, at brug af følsomme CYP3A-substrater bør undgås to uger før registrering og under undersøgelsesbehandling. Derudover er CYP3A4- eller CYP2C8-inducere forbudt som samtidig medicin inden for 5 dage efter seponering af tucatinib-behandling. Patienter, der har behov for medicin, der vides at være følsomme substrater for CYP3A4 med et snævert terapeutisk vindue, bør udelukkes.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Dobbelt

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Aktiv komparator: Arm I (trastuzumab emtansin, placebo) Patienterne modtager T-DM1 IV over 30-90 minutter på dag 1 og placebo PO BID på dag 1-21. Behandlingen gentages hver 21. dag i op til 14 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet.	Andet: Livskvalitetsvurdering Hjælpestudier Andet: Spørgeskemaadministration Hjælpestudier Biologisk: Trastuzumab Emtansine Givet IV Medicin: Placebo administration Givet PO
Eksperimentel: Arm II (trastuzumab emtansin, tucatinib) Patienter får T-DM1 IV over 30-90 minutter på dag 1 og tucatinib PO BID på dag 1-21. Behandlingen gentages hver 21. dag i op til 14 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet.	Andet: Livskvalitetsvurdering Hjælpestudier Andet: Spørgeskemaadministration Hjælpestudier Biologisk: Trastuzumab Emtansine Givet IV Medicin: Tucatinib Givet PO

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Modificeret invasiv sygdomsfri overlevelse (iDFS) Tidsramme: Fra randomisering til en af følgende hændelser: invasiv lokal, regional eller fjern recidiv, invasiv kontralateral brystkræft eller død af enhver årsag, vurderet op til 10 år	En Kaplan-Meier metode vil blive brugt til at estimere overlevelseskurverne og en stratificeret log-rank test vil blive brugt til at sammenligne den invasive sygdomsfri overlevelse (iDFS) af de to arme. En stratificeret Cox-model vil blive brugt til at estimere hazard ratio. Hvis der ser ud til at være klinisk signifikante ubalancer af baseline-variabler mellem behandlingsarmene, vil en sekundær analyse af det primære endepunkt bruge en stratificeret Cox-model til at sammenligne behandlingseffekterne, der inkluderer de variabler, der anses for ubalancerede mellem armene som justerende variable. Randomiseringsstratifikationsvariablene vil være de stratificerede variabler i modellen.	Fra randomisering til en af følgende hændelser: invasiv lokal, regional eller fjern recidiv, invasiv kontralateral brystkræft eller død af enhver årsag, vurderet op til 10 år

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Umodificeret invasiv sygdomsfri overlevelse (iDFS) Tidsramme: Op til 10 år	Vil blive defineret som tiden fra randomisering til en af følgende hændelser: invasiv lokal, regional eller fjern recidiv, invasiv kontralateral brystkræft sekundær primær invasiv cancer (bortset fra basal- eller pladecellekarcinom i huden eller carcinom in situ i livmoderhalsen ), eller død af enhver årsag, vurderet op til 10 år. En Kaplan-Meier metode vil blive brugt til at estimere overlevelseskurverne, og en stratificeret log-rank test vil blive brugt til at sammenligne iDFS for de to arme. En stratificeret Cox-model vil blive brugt til at estimere hazard ratio.	Op til 10 år
Brystkræftfri overlevelse Tidsramme: Fra randomisering til invasiv lokal, regional eller fjern recidiv eller invasiv kontralateral brystkræft, vurderet op til 10 år	Vil blive opsummeret med Kaplan-Meier kurver og sammenlignet mellem armene ved hjælp af en stratificeret log-rank test og stratificeret Cox model. Hvis der er klinisk signifikante ubalancer i baseline-karakteristika mellem behandlingsarmene, vil en anden analyse blive udført ved hjælp af en stratificeret Cox-model med de variabler, der er ubalance tilføjet som justerende variable.	Fra randomisering til invasiv lokal, regional eller fjern recidiv eller invasiv kontralateral brystkræft, vurderet op til 10 år
Fjern gentagelsesfri overlevelse Tidsramme: Fra randomisering til første forekomst af fjernt tilbagefald, vurderet op til 10 år	Vil blive opsummeret med Kaplan-Meier kurver og sammenlignet mellem armene ved hjælp af en stratificeret log-rank test og stratificeret Cox model. Hvis der er klinisk signifikante ubalancer i baseline-karakteristika mellem behandlingsarmene, vil en anden analyse blive udført ved hjælp af en stratificeret Cox-model med de variabler, der er ubalance tilføjet som justerende variable.	Fra randomisering til første forekomst af fjernt tilbagefald, vurderet op til 10 år
Hjernemetastasefri overlevelse Tidsramme: Fra randomisering til dokumentation af involvering af centralnervesystemet ved metastatisk cancer, herunder parenkymale hjerne- og rygmarvsmetastaser samt leptomeningeal carcinomatose, vurderet op til 10 år	Vil blive opsummeret med Kaplan-Meier kurver og sammenlignet mellem armene ved hjælp af en stratificeret log-rank test og stratificeret Cox model. Hvis der er klinisk signifikante ubalancer i baseline-karakteristika mellem behandlingsarmene, vil en anden analyse blive udført ved hjælp af en stratificeret Cox-model med de variabler, der er ubalance tilføjet som justerende variable.	Fra randomisering til dokumentation af involvering af centralnervesystemet ved metastatisk cancer, herunder parenkymale hjerne- og rygmarvsmetastaser samt leptomeningeal carcinomatose, vurderet op til 10 år
Samlet overlevelse Tidsramme: Fra randomisering til død uanset årsag, vurderet op til 10 år	Vil blive opsummeret med Kaplan-Meier kurver og sammenlignet mellem armene ved hjælp af en stratificeret log-rank test og stratificeret Cox model. Hvis der er klinisk signifikante ubalancer i baseline-karakteristika mellem behandlingsarmene, vil en anden analyse blive udført ved hjælp af en stratificeret Cox-model med de variabler, der er ubalance tilføjet som justerende variable.	Fra randomisering til død uanset årsag, vurderet op til 10 år
Forekomst af hjernemetastaser Tidsramme: Op til 10 år	En hændelse af hjernemetastaser er dokumentation for involvering af centralnervesystemet ved metastatisk cancer, herunder parenkymale hjerne- og rygmarvsmetastaser samt leptomeningeal carcinomatose. Den kumulative forekomst af hjernemetastaser vil blive bestemt som den rå kumulative forekomst såvel som med forekomsten med konkurrerende risici, hvor den konkurrerende begivenhed er død.	Op til 10 år

Andre resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Livskvalitet Tidsramme: Op til 8 behandlingscyklusser (hver cyklus er 21 dage)	Vil blive vurderet af Functional Assessment of Cancer Therapy (FACT)-Breast Cancer (B) Trial Outcome Index spørgeskema. Den blandede model vil sammenligne tidspunkterne for cyklus 9 dag 1 og cyklus 14 dag 1 mellem randomiserede arme. Ud over en randomiseret arm-kovariat vil modellen inkludere et randomiseret arm-for-tid interaktionsudtryk og vil bruge den planlagte vurderingscyklus som den kategoriske tidsværdi. Ustruktureret kovarians vil i første omgang blive brugt, selvom alternative kovariansstrukturer vil blive undersøgt med den endelige kovariansstruktur valgt baseret på minimering af Akaike informationskriteriet. En kontrast vil blive brugt til at sammenligne den gennemsnitlige ændring fra baseline ved cyklus 9 dag 1 mellem armene. Hvis det tosidede 95 % konfidensinterval udelukker en forskel på 5, der favoriserer trastuzumab emtansin (T-DM1) + placebo-armen, vil non-inferiority blive konkluderet.	Op til 8 behandlingscyklusser (hver cyklus er 21 dage)
Livskvalitet Tidsramme: Op til 13 behandlingscyklusser (hver cyklus er 21 dage)	Vil blive vurderet af Functional Assessment of Cancer Therapy (FACT)-Breast Cancer (B) Trial Outcome Index spørgeskema. Den blandede model vil sammenligne den gennemsnitlige ændring fra baseline ved cyklus 14 dag 1 mellem armene. Hvis det tosidede 95 % konfidensinterval udelukker en forskel på 5, der favoriserer T-DM1 + placebo-armen, vil non-inferiority blive konkluderet på dette tidspunkt.	Op til 13 behandlingscyklusser (hver cyklus er 21 dage)

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Alliance for Clinical Trials in Oncology

Samarbejdspartnere

National Cancer Institute (NCI)

Seagen Inc.

Efterforskere

Studiestol: Ciara C. O'Sullivan, MB, BCh, BAO, Mayo Clinic

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

O'Sullivan CC, Ballman KV, McCall L, Kommalapati A, Zemla T, Weiss A, Mitchell M, Blinder V, Tung NM, Irvin WJ, Lee M, Goetz MP, Symmans WF, Borges VF, Krop I, Carey LA, Partridge AH. Alliance A011801 (compassHER2 RD): postneoadjuvant T-DM1 + tucatinib/placebo in patients with residual HER2-positive invasive breast cancer. Future Oncol. 2021 Dec;17(34):4665-4676. doi: 10.2217/fon-2021-0753. Epub 2021 Oct 12.

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

2. marts 2021

Primær færdiggørelse (Anslået)

31. januar 2028

Studieafslutning (Anslået)

31. maj 2035

Datoer for studieregistrering

Først indsendt

30. juni 2020

Først indsendt, der opfyldte QC-kriterier

30. juni 2020

Først opslået (Faktiske)

7. juli 2020

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Anslået)

29. oktober 2025

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

28. oktober 2025

Sidst verificeret

1. oktober 2025

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

A011801
U10CA180821 (U.S. NIH-bevilling/kontrakt)
NCI-2020-03770 (Registry Identifier: NCI Clinical Trial Reporting Program)

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

produkt fremstillet i og eksporteret fra U.S.A.

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Livskvalitetsvurdering

Seoul National University Hospital

Trukket tilbage

Virkninger af præoperativ angst og depression på kortsigtet postoperativ restitution ved tidlig gastrisk cancer

Depression | Postoperative komplikationer | Angst | Mestringsadfærd

Korea, Republikken
Memorial Sloan Kettering Cancer Center

Afsluttet

Indvirkning af palliativ kateterplacering på livskvaliteten for patienter med refraktær ascites

Ascites

Forenede Stater
Latin American Cooperative Oncology Group
Roche Pharma AG; EVA - Grupo Brasileiro de Tumores Ginecológicos

Afsluttet

Prospektiv evaluering af patienter med livmoderhalskræft i brasilianske sundhedsinstitutioner - EVITA I-undersøgelsen

Livmoderhalskræft

Brasilien
Ankara University

Afsluttet

ValideringTurkishVersionQualityofRecovery-15 (ValidQoR-15)

Større abdominal kirurgi | Patientrapporteret resultat

Kalkun
Kutahya Health Sciences University

Afsluttet

Tyrkisk gyldighed og pålidelighed af smertekatastrofiserende scale-Child (PCS-C)

Kronisk smerte | Juvenil idiopatisk arthritis

Kalkun
University of Florida

Afsluttet

Medlidenhedstræthed hos ED-udbydere

Medfølelse Træthed

Forenede Stater
World Vision Canada
Ryerson University; World Health Organization; Global Affairs Canada; Ministry...

Afsluttet

Klinisk evaluering af brugen af en mHealth-intervention om plejekvalitet

Diarré | Malaria | Akut luftvejsinfektion
Maastricht University
TNO; Netherlands Instititute for Health Services Research; University of...

Afsluttet

Effektivitet og implementering af værktøjet til vurdering af byrde ved kroniske lidelser (ABCC)

Hjertefejl | Diabetes mellitus, type 2 | Kronisk obstruktiv lungesygdom | Astma

Holland
University Hospital, Strasbourg, France

Afsluttet

Validering af en pædiatrisk billedversion af QOR-15 Postoperatory Functional Recovery Scale - QoR-15 Pédiatric

Kirurgisk indgreb | Mindre

Frankrig
King's College London
Guy's and St Thomas' NHS Foundation Trust

Afsluttet

Livskvalitetsværktøj til IBD (QOLITI)

Inflammatorisk tarmsygdom

Det Forenede Kongerige

T-DM1 og Tucatinib sammenlignet med T-DM1 alene til at forebygge tilbagefald hos mennesker med højrisiko HER2-positiv brystkræft, CompassHER2 RD-forsøget

CompassHER2-forsøgene (omfattende brug af patologisk responsvurdering til at optimere terapi ved HER2-positiv brystkræft) CompassHER2 Residual Disease (RD), et dobbeltblindet, fase III randomiseret forsøg med T-DM1 sammenlignet med T-DM1 og Tucatinib

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Andre resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Publikationer og nyttige links

Generelle publikationer

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Anslået)

Studieafslutning (Anslået)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Faktiske)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Anslået)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

produkt fremstillet i og eksporteret fra U.S.A.

Kliniske forsøg med Livskvalitetsvurdering

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Congo, DR of

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer