Effects of Inter-Set Rest Intervals on Muscle Damage After Flywheel Exercise in Untrained Men (RCT)
2026年9月8日 更新者：Federal University of Vicosa
Effects of Different Inter-Set Rest Intervals on Indirect Markers of Muscle Damage and Mechanical Parameters After Flywheel Resistance Training in Untrained Men: A Randomized Parallel-Group Clinical Trial
This randomized parallel-group clinical trial will compare the acute effects of three different inter-set rest intervals during a single lower-limb flywheel resistance exercise session in untrained men.
Participants will be randomly allocated to one of three groups: 1-minute, 2-minute, or 3-minute inter-set rest interval.
The primary outcome will be the change in maximal voluntary isometric contraction of the knee extensors 48 hours after exercise.
Secondary outcomes will include mechanical variables during the exercise session, countermovement jump performance, knee flexor maximal voluntary isometric contraction, muscle soreness, pressure pain threshold, range of motion, ultrasound-derived muscle thickness and echo intensity, perceived exertion, perceived discomfort, perceived recovery status, creatine kinase, and lactate dehydrogenase.
研究概览
地位
招聘中
条件
详细说明
Participants will complete seven laboratory visits. The first two visits will be used for baseline assessments and test-retest reliability. The third and fourth visits will be used for technical familiarization with the flywheel exercises. The fifth visit will include the experimental flywheel resistance exercise session and immediate post-exercise assessments. The sixth and seventh visits will include follow-up assessments 48 and 96 hours after the experimental session, respectively. Blood samples for creatine kinase and lactate dehydrogenase will be collected before the experimental session and 72 hours after exercise in a partner laboratory.
The experimental session will include squat, Romanian deadlift, knee extension, and knee flexion exercises performed using flywheel devices. All groups will perform the same exercises, volume, inertia, and execution instructions. The only difference between groups will be the inter-set rest interval: 1 minute, 2 minutes, or 3 minutes.
研究类型
介入性
注册 (估计的)
30
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
-
-
Minas Gerais
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Viçosa、Minas Gerais、巴西、36570-900
- 招聘中
- Federal University of Vicosa
-
接触：
- Study Coordinator
- 电话号码：(31) 98359-5541
- 邮箱：wanderson.machado@ufv.br
-
-
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
- 成人
接受健康志愿者
是的
描述
Inclusion Criteria:
- Age between 18 and 40 years;
- Apparently healthy and clinically able to perform physical exercise;
- No participation in structured resistance training during the previous 6 months;
- Agreement to comply with all study visits and procedures;
- Signed informed consent form.
Exclusion Criteria:
- History of lower-limb musculoskeletal injury or surgery that may impair performance or safety during the proposed exercise protocol;
- Current pain, injury, or functional limitation in the lower limbs;
- Use of ergogenic aids that may affect physical performance or muscle recovery;
- Use of analgesic or anti-inflammatory medication during the study period;
- Failure to attend the scheduled visits required for the primary outcome assessment.
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：1-Minute Inter-set Rest Interval
Participants allocated to this group will perform a single lower-limb flywheel resistance exercise session using a 1-minute inter-set rest interval.
The session will include squat, Romanian deadlift, knee extension, and knee flexion exercises.
|
Participants will perform a single lower-limb flywheel resistance exercise session using a 1-minute inter-set rest interval.
The session will include squat, Romanian deadlift, knee extension, and knee flexion exercises.
Each exercise will be performed for 4 sets of 2 preparatory repetitions followed by 8 valid repetitions, using the same flywheel inertia, exercise order, and execution instructions across all groups.
Participants will be instructed to perform the concentric phase as fast as possible and to brake the eccentric phase during the final portion of the movement.
The interval between exercises will be standardized at 3 minutes.
|
|
实验性的：2-Minute Inter-set Rest Interval
Participants allocated to this group will perform a single lower-limb flywheel resistance exercise session using a 1-minute inter-set rest interval.
The session will include squat, Romanian deadlift, knee extension, and knee flexion exercises.
|
Participants will perform a single lower-limb flywheel resistance exercise session using a 2-minute inter-set rest interval.
The session will include squat, Romanian deadlift, knee extension, and knee flexion exercises.
Each exercise will be performed for 4 sets of 2 preparatory repetitions followed by 8 valid repetitions, using the same flywheel inertia, exercise order, and execution instructions across all groups.
Participants will be instructed to perform the concentric phase as fast as possible and to brake the eccentric phase during the final portion of the movement.
The interval between exercises will be standardized at 3 minutes.
|
|
实验性的：3-Minute Inter-set Rest Interval
Participants allocated to this group will perform a single lower-limb flywheel resistance exercise session using a 1-minute inter-set rest interval.
The session will include squat, Romanian deadlift, knee extension, and knee flexion exercises.
|
Participants will perform a single lower-limb flywheel resistance exercise session using a 3-minute inter-set rest interval.
The session will include squat, Romanian deadlift, knee extension, and knee flexion exercises.
Each exercise will be performed for 4 sets of 2 preparatory repetitions followed by 8 valid repetitions, using the same flywheel inertia, exercise order, and execution instructions across all groups.
Participants will be instructed to perform the concentric phase as fast as possible and to brake the eccentric phase during the final portion of the movement.
The interval between exercises will be standardized at 3 minutes.
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Change in maximal voluntary isometric contraction of the knee extensors
大体时间：Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
|
Maximal voluntary isometric contraction of the knee extensors will be assessed using a load cell with the knee positioned at 90 degrees of flexion.
The primary outcome will be the change in force between baseline and immediately, 48 hours, and 96 hours after the experimental exercise session using a flywheel.
|
Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
|
|
Change in maximal voluntary isometric contraction of the knee flexors
大体时间：Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
|
The maximum voluntary isometric contraction of the knee flexors will be assessed using a load cell with the knee positioned at 45 degrees of flexion.
The primary outcome will be the change in force between baseline and immediately, 48 hours, and 96 hours after the experimental exercise session using a flywheel.
|
Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Change in vastus lateralis and biceps femoris long head muscle thickness
大体时间：Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
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Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
|
|
|
Change in vastus lateralis and biceps femoris long head echo intensity
大体时间：Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
|
Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
|
|
|
Change in countermovement jump performance
大体时间：Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
|
Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
|
|
|
Change in active and passive knee flexion and extension range of motion
大体时间：Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
|
Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
|
|
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Change in lower-limb muscle soreness score assessed by the Visual Analogue Scale
大体时间：Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
|
Lower-limb muscle soreness will be assessed using a 100-mm Visual Analogue Scale.
The scale ranges from 0 to 100, where 0 indicates no pain and 100 indicates the worst possible pain.
Higher scores indicate greater muscle soreness.
The outcome will be reported as the change in muscle soreness score from baseline to the post-exercise time points.
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Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
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Change in pressure pain threshold of the thigh muscles
大体时间：Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
|
Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
|
|
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Change in serum creatine kinase and lactate dehydrogenase concentrations
大体时间：Pre-exercise and 72 hours after the experimental exercise session
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Pre-exercise and 72 hours after the experimental exercise session
|
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Peak concentric and eccentric power output during flywheel exercise
大体时间：During all 16 sets performed in the experimental exercise session
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Peak concentric and eccentric power output will be recorded during each valid repetition of the flywheel exercise session using a load cell connected to the flywheel device.
Data will be collected for all sets and exercises, excluding the initial preparatory repetitions.
The outcome will be reported as peak concentric power, peak eccentric power, and eccentric/concentric power ratio across the experimental exercise session.
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During all 16 sets performed in the experimental exercise session
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Rating of perceived exertion assessed by the OMNI-Resistance Exercise Scale
大体时间：After each of the 16 sets performed during the experimental exercise session and 10 minutes after the experimental exercise session
|
Rating of perceived exertion will be assessed using the OMNI-Resistance Exercise Scale.
The scale ranges from 0 to 10, where 0 indicates extremely easy and 10 indicates extremely hard.
Higher scores indicate greater perceived exertion.
The outcome will be reported after each set of the experimental flywheel exercise session and 10 minutes after the end of the session.
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After each of the 16 sets performed during the experimental exercise session and 10 minutes after the experimental exercise session
|
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Perceived discomfort assessed by the Discomfort Scale
大体时间：After each of the 16 sets performed during the experimental exercise session and 10 minutes after the experimental exercise session
|
Perceived discomfort will be assessed using a 0-to-100 Discomfort Scale.
The scale ranges from 0 to 100, where 0 indicates no discomfort and 100 indicates maximal discomfort.
Higher scores indicate greater perceived discomfort.
The outcome will be reported after each set of the experimental flywheel exercise session and 10 minutes after the end of the session.
|
After each of the 16 sets performed during the experimental exercise session and 10 minutes after the experimental exercise session
|
|
Perceived recovery status assessed by the Perceived Recovery Status Scale
大体时间：Baseline, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
|
Perceived recovery status will be assessed using the Perceived Recovery Status Scale.
The scale ranges from 0 to 10, where 0 indicates very poor recovery and 10 indicates full recovery.
Higher scores indicate better perceived recovery.
The outcome will be reported as the perceived recovery status score at baseline and at the post-exercise follow-up time points.
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Baseline, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2026年6月1日
初级完成 (估计的)
2026年10月1日
研究完成 (估计的)
2026年10月1日
研究注册日期
首次提交
2026年5月29日
首先提交符合 QC 标准的
2026年6月25日
首次发布 (实际的)
2026年7月1日
研究记录更新
最后更新发布 (实际的)
2026年9月11日
上次提交的符合 QC 标准的更新
2026年9月8日
最后验证
2026年9月1日
更多信息
与本研究相关的术语
其他研究编号
- 7.151.525 (其他标识符：Ethics Committee Approval Number)
- 81740024.5.0000.5153 (其他标识符：CAAE)
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
不
药物和器械信息、研究文件
研究美国 FDA 监管的药品
不
研究美国 FDA 监管的设备产品
不
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.