Phosphatidylserine, Taurine, and Caffeine for Cognitive Fatigue in Professional Football Players (TCPS-Foot)
2026年9月9日 更新者：Krzysztof Mizera、Vizja University in Warsaw
Neurocognitive Fatigue Resistance, Visual Search Efficiency, and Tactical Decision-Making After Phosphatidylserine-Containing Taurine-Caffeine Supplementation in Professional Male Football Players
This randomized, double-blind, placebo-controlled, parallel-group trial evaluated neurocognitive fatigue resistance and football-specific decision-making following 28 days of taurine-caffeine supplementation with or without phosphatidylserine in professional male football players.
Sixty-five male outfield football players from two professional clubs were randomized to placebo, taurine plus caffeine, or taurine plus caffeine plus phosphatidylserine.
Neurocognitive fatigue resistance was evaluated during a standardized high-load Stroop/Flanker task, while football-specific tactical decision-making, visual-search behavior, and field-based reactive decision performance were assessed at baseline and after 28 days of supplementation.
研究概览
地位
完全的
详细说明
This study was designed to determine whether adding phosphatidylserine to taurine-caffeine supplementation improves neurocognitive fatigue resistance and football-specific decision-making in professional male football players.
Participants completed familiarization procedures, baseline laboratory and field testing, 28 days of supplementation, and post-intervention laboratory and field testing.
Neurocognitive fatigue resistance was assessed using a standardized high-load Stroop/Flanker protocol.
Football-specific decision-making was evaluated using video-based tactical decision tasks incorporating offensive and transitional match situations and requiring rapid selection of the most appropriate tactical response.
Visual-search behavior was assessed using screen-based eye tracking during the football-specific decision task.
Field-based reactive decision performance was evaluated using a standardized Reactive Passing Decision Test requiring perception of an external visual stimulus followed by selection and execution of the appropriate passing response.
Outcome assessments were conducted before and after the 28-day supplementation period under standardized testing conditions.
研究类型
介入性
注册 (实际的)
65
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
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Lodz、波兰
- Professional Football Training Center
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Warsaw、波兰
- Professional Football Training Center
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参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
- 成人
接受健康志愿者
是的
描述
Inclusion Criteria:
- Male professional outfield football players aged 18 to 37 years.
- First-team players or selected U19 players aged 18 years or older who are regularly integrated into first-team training.
- Regular participation in club training.
- At least 5 years of systematic football training experience.
- Free from injury or illness limiting full participation in training and testing.
- Normal or corrected-to-normal vision.
- Ability to complete the laboratory and field-based testing procedures.
- Written informed consent provided before participation.
Exclusion Criteria:
- Goalkeepers.
- Current injury or illness limiting full participation in testing.
- Neurological disease.
- Recent concussion or head trauma.
- Uncorrected visual impairment.
- Use of phosphatidylserine, nootropic agents, or strong stimulants during the previous 4 weeks.
- Non-standard caffeine intake on testing days.
- Failure to comply with pre-test standardization procedures.
- Failed eye-tracker calibration.
- Loss of more than 30% of gaze data during the football-specific decision-making task.
- Withdrawal of consent.
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：其他
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：四人间
武器和干预
参与者组/臂 |
干预/治疗 |
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安慰剂比较：Placebo
Participants randomized to this arm will receive an inert placebo for 28 days.
The placebo will be provided in identical coded packs matched for appearance, number of units, and packaging with the active supplements.
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Inert placebo matched with the active supplements for appearance, number of units, and packaging.
The placebo will be administered for 28 days.
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有源比较器：Taurine Plus Caffeine
Participants randomized to this arm will receive taurine 1500 mg/day plus caffeine 200 mg/day for 28 days.
On training and testing days, the supplement will be consumed approximately 60 minutes before the main training session or testing procedure.
On non-training days, it will be consumed at a consistent morning time.
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Taurine 1500 mg/day plus caffeine 200 mg/day administered for 28 days.
On training and testing days, the supplement will be consumed approximately 60 minutes before the main training session or testing procedure.
On non-training days, it will be consumed at a consistent morning time.
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实验性的：Taurine, Caffeine, and Phosphatidylserine
Participants randomized to this arm will receive taurine 1500 mg/day plus caffeine 200 mg/day plus phosphatidylserine 600 mg/day for 28 days.
On training and testing days, the supplement will be consumed approximately 60 minutes before the main training session or testing procedure.
On non-training days, it will be consumed at a consistent morning time.
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Taurine 1500 mg/day plus caffeine 200 mg/day plus phosphatidylserine 600 mg/day administered for 28 days.
On training and testing days, the supplement will be consumed approximately 60 minutes before the main training session or testing procedure.
On non-training days, it will be consumed at a consistent morning time.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Tactical Inhibitory Decision Accuracy Under Neurocognitive Load
大体时间：Baseline and 28 days of supplementation
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Tactical inhibitory decision accuracy will be assessed using football-specific video clips requiring inhibition of an immediately attractive but suboptimal tactical action.
Responses will be scored as 1 point for an optimal decision, 0.5 points for an acceptable decision, and 0 points for an incorrect decision.
The outcome will be calculated as the mean score across inhibitory tactical clips.
The score ranges from 0 to 1, with higher values indicating better tactical inhibitory decision accuracy.
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Baseline and 28 days of supplementation
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Overall Football-Specific Optimal Decision Rate
大体时间：Baseline and 28 days of supplementation
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Overall football-specific decision accuracy will be assessed using video-based offensive and transitional football situations.
Players will select the most appropriate tactical option under time pressure.
The outcome will be expressed as the percentage of correct or expert-rated optimal decisions, with higher values indicating better decision-making accuracy.
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Baseline and 28 days of supplementation
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Football-Specific Decision Time
大体时间：Baseline and 28 days of supplementation
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Decision time will be assessed during the football-specific video decision-making task.
It will be measured as the time taken to select a tactical response after the critical decision point.
The outcome will be expressed in milliseconds, with lower values indicating faster decision-making.
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Baseline and 28 days of supplementation
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Impulsive Tactical Error Rate
大体时间：Baseline and 28 days of supplementation
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Impulsive tactical errors will be assessed during football-specific video clips.
These errors will include selections of immediately attractive but suboptimal tactical options, such as inappropriate forward actions, low-quality shots, or forced progressive decisions when a safer or more appropriate option is available.
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Baseline and 28 days of supplementation
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Stroop/Flanker Time-on-Task Reaction-Time Trajectory
大体时间：Baseline and 28 days of supplementation
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Correct-trial reaction time will be assessed across six consecutive 5-minute epochs of the 30-minute high-load Stroop/Flanker task.
Time-on-task performance decrement will be quantified from the within-session trajectory of reaction time across successive epochs, with a greater increase in reaction time indicating greater neurocognitive performance deterioration and a smaller increase indicating greater neurocognitive fatigue resistance.
Response accuracy across epochs will be reported as a complementary measure.
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Baseline and 28 days of supplementation
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Stroop/Flanker Reaction-Time Variability
大体时间：Baseline and 28 days of supplementation
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Reaction-time variability will be assessed during the 30-minute high-load Stroop/Flanker task.
It will be quantified from valid correct-trial reaction times as a within-participant measure of response-time variability and expressed in milliseconds, with greater variability indicating lower response stability.
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Baseline and 28 days of supplementation
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Post-Task Mental Fatigue
大体时间：Baseline and 28 days of supplementation
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Perceived mental fatigue will be assessed immediately before and immediately after the 30-minute neurocognitive-load task using a 0-10 numerical rating scale, with higher scores indicating greater perceived mental fatigue.
The registered outcome will be the post-task mental-fatigue score assessed at baseline and after 28 days of supplementation.
The acute pre-to-post task change will additionally be used as a manipulation check of the neurocognitive-load protocol.
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Baseline and 28 days of supplementation
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Time to First Fixation on the Optimal Tactical Area of Interest
大体时间：Baseline and 28 days of supplementation
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Time to first fixation on the optimal tactical option will be assessed using screen-based eye-tracking during the football-specific video decision-making task.
The outcome will be expressed in milliseconds and will reflect how quickly the player visually orients toward the expert-defined optimal option.
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Baseline and 28 days of supplementation
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Dwell Time on the Optimal Tactical Area of Interest
大体时间：Baseline and 28 days of supplementation
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Dwell time on the optimal tactical option will be assessed using screen-based eye-tracking during the football-specific video decision-making task.
The outcome will be expressed as the percentage of total viewing time spent fixating on the expert-defined optimal tactical option.
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Baseline and 28 days of supplementation
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Situational-Awareness Accuracy
大体时间：Baseline and 28 days of supplementation
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Situational awareness accuracy will be assessed using probes presented after selected football-specific video clips.
These probes will evaluate whether players correctly identified key tactical information, including available space, pressure location, number of defenders, teammate positioning, and defensive-line configuration.
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Baseline and 28 days of supplementation
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Reactive Passing Decision-Selection Accuracy
大体时间：Baseline and 28 days of supplementation
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Reactive Passing Decision Test accuracy will be assessed during a field-based football-specific task.
Players will dribble into a decision zone and respond to a late visual or situational cue by selecting and executing the optimal passing option.
The outcome will be expressed as the percentage of accurate decisions.
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Baseline and 28 days of supplementation
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2026年8月6日
初级完成 (实际的)
2026年9月8日
研究完成 (实际的)
2026年9月8日
研究注册日期
首次提交
2026年7月5日
首先提交符合 QC 标准的
2026年7月5日
首次发布 (实际的)
2026年7月10日
研究记录更新
最后更新发布 (实际的)
2026年9月14日
上次提交的符合 QC 标准的更新
2026年9月9日
最后验证
2026年9月1日
更多信息
与本研究相关的术语
关键字
其他相关的 MeSH 术语
其他研究编号
- MIZERA -4-TCPS-FOOT-2026
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
不
IPD 计划说明
No individual participant data will be shared because the study includes a small sample of professional football players from a limited number of clubs, which may increase the risk of indirect participant identification.
Only aggregated and anonymized study results will be reported.
药物和器械信息、研究文件
研究美国 FDA 监管的药品
不
研究美国 FDA 监管的设备产品
不
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.