Diese Seite wurde automatisch übersetzt und die Genauigkeit der Übersetzung wird nicht garantiert. Bitte wende dich an die englische Version für einen Quelltext.

Phosphatidylserine, Taurine, and Caffeine for Cognitive Fatigue in Professional Football Players (TCPS-Foot)

9. September 2026 aktualisiert von: Krzysztof Mizera, Vizja University in Warsaw

Neurocognitive Fatigue Resistance, Visual Search Efficiency, and Tactical Decision-Making After Phosphatidylserine-Containing Taurine-Caffeine Supplementation in Professional Male Football Players

This randomized, double-blind, placebo-controlled, parallel-group trial evaluated neurocognitive fatigue resistance and football-specific decision-making following 28 days of taurine-caffeine supplementation with or without phosphatidylserine in professional male football players. Sixty-five male outfield football players from two professional clubs were randomized to placebo, taurine plus caffeine, or taurine plus caffeine plus phosphatidylserine. Neurocognitive fatigue resistance was evaluated during a standardized high-load Stroop/Flanker task, while football-specific tactical decision-making, visual-search behavior, and field-based reactive decision performance were assessed at baseline and after 28 days of supplementation.

Studienübersicht

Status

Abgeschlossen

Bedingungen

Intervention / Behandlung

Detaillierte Beschreibung

This study was designed to determine whether adding phosphatidylserine to taurine-caffeine supplementation improves neurocognitive fatigue resistance and football-specific decision-making in professional male football players. Participants completed familiarization procedures, baseline laboratory and field testing, 28 days of supplementation, and post-intervention laboratory and field testing. Neurocognitive fatigue resistance was assessed using a standardized high-load Stroop/Flanker protocol. Football-specific decision-making was evaluated using video-based tactical decision tasks incorporating offensive and transitional match situations and requiring rapid selection of the most appropriate tactical response. Visual-search behavior was assessed using screen-based eye tracking during the football-specific decision task. Field-based reactive decision performance was evaluated using a standardized Reactive Passing Decision Test requiring perception of an external visual stimulus followed by selection and execution of the appropriate passing response. Outcome assessments were conducted before and after the 28-day supplementation period under standardized testing conditions.

Studientyp

Interventionell

Einschreibung (Tatsächlich)

65

Phase

  • Unzutreffend

Kontakte und Standorte

Dieser Abschnitt enthält die Kontaktdaten derjenigen, die die Studie durchführen, und Informationen darüber, wo diese Studie durchgeführt wird.

Studienorte

  • Polen
      • Lodz, Polen
        • Professional Football Training Center
      • Warsaw, Polen
        • Professional Football Training Center

Teilnahmekriterien

Forscher suchen nach Personen, die einer bestimmten Beschreibung entsprechen, die als Auswahlkriterien bezeichnet werden. Einige Beispiele für diese Kriterien sind der allgemeine Gesundheitszustand einer Person oder frühere Behandlungen.

Zulassungskriterien

Studienberechtigtes Alter

  • Erwachsene

Akzeptiert gesunde Freiwillige

Ja

Beschreibung

Inclusion Criteria:

  • Male professional outfield football players aged 18 to 37 years.
  • First-team players or selected U19 players aged 18 years or older who are regularly integrated into first-team training.
  • Regular participation in club training.
  • At least 5 years of systematic football training experience.
  • Free from injury or illness limiting full participation in training and testing.
  • Normal or corrected-to-normal vision.
  • Ability to complete the laboratory and field-based testing procedures.
  • Written informed consent provided before participation.

Exclusion Criteria:

  • Goalkeepers.
  • Current injury or illness limiting full participation in testing.
  • Neurological disease.
  • Recent concussion or head trauma.
  • Uncorrected visual impairment.
  • Use of phosphatidylserine, nootropic agents, or strong stimulants during the previous 4 weeks.
  • Non-standard caffeine intake on testing days.
  • Failure to comply with pre-test standardization procedures.
  • Failed eye-tracker calibration.
  • Loss of more than 30% of gaze data during the football-specific decision-making task.
  • Withdrawal of consent.

Studienplan

Dieser Abschnitt enthält Einzelheiten zum Studienplan, einschließlich des Studiendesigns und der Messung der Studieninhalte.

Wie ist die Studie aufgebaut?

Designdetails

  • Hauptzweck: Sonstiges
  • Zuteilung: Zufällig
  • Interventionsmodell: Parallele Zuordnung
  • Maskierung: Vervierfachen

Waffen und Interventionen

Teilnehmergruppe / Arm
Intervention / Behandlung
Placebo-Komparator: Placebo
Participants randomized to this arm will receive an inert placebo for 28 days. The placebo will be provided in identical coded packs matched for appearance, number of units, and packaging with the active supplements.
Nahrungsergänzungsmittel: Placebo
Inert placebo matched with the active supplements for appearance, number of units, and packaging. The placebo will be administered for 28 days.
Aktiver Komparator: Taurine Plus Caffeine
Participants randomized to this arm will receive taurine 1500 mg/day plus caffeine 200 mg/day for 28 days. On training and testing days, the supplement will be consumed approximately 60 minutes before the main training session or testing procedure. On non-training days, it will be consumed at a consistent morning time.
Nahrungsergänzungsmittel: Taurine Plus Caffeine
Taurine 1500 mg/day plus caffeine 200 mg/day administered for 28 days. On training and testing days, the supplement will be consumed approximately 60 minutes before the main training session or testing procedure. On non-training days, it will be consumed at a consistent morning time.
Experimental: Taurine, Caffeine, and Phosphatidylserine
Participants randomized to this arm will receive taurine 1500 mg/day plus caffeine 200 mg/day plus phosphatidylserine 600 mg/day for 28 days. On training and testing days, the supplement will be consumed approximately 60 minutes before the main training session or testing procedure. On non-training days, it will be consumed at a consistent morning time.
Nahrungsergänzungsmittel: Taurine, Caffeine, and Phosphatidylserine
Taurine 1500 mg/day plus caffeine 200 mg/day plus phosphatidylserine 600 mg/day administered for 28 days. On training and testing days, the supplement will be consumed approximately 60 minutes before the main training session or testing procedure. On non-training days, it will be consumed at a consistent morning time.

Was misst die Studie?

Primäre Ergebnismessungen

Ergebnis Maßnahme
Maßnahmenbeschreibung
Zeitfenster
Tactical Inhibitory Decision Accuracy Under Neurocognitive Load
Zeitfenster: Baseline and 28 days of supplementation
Tactical inhibitory decision accuracy will be assessed using football-specific video clips requiring inhibition of an immediately attractive but suboptimal tactical action. Responses will be scored as 1 point for an optimal decision, 0.5 points for an acceptable decision, and 0 points for an incorrect decision. The outcome will be calculated as the mean score across inhibitory tactical clips. The score ranges from 0 to 1, with higher values indicating better tactical inhibitory decision accuracy.
Baseline and 28 days of supplementation

Sekundäre Ergebnismessungen

Ergebnis Maßnahme
Maßnahmenbeschreibung
Zeitfenster
Overall Football-Specific Optimal Decision Rate
Zeitfenster: Baseline and 28 days of supplementation
Overall football-specific decision accuracy will be assessed using video-based offensive and transitional football situations. Players will select the most appropriate tactical option under time pressure. The outcome will be expressed as the percentage of correct or expert-rated optimal decisions, with higher values indicating better decision-making accuracy.
Baseline and 28 days of supplementation
Football-Specific Decision Time
Zeitfenster: Baseline and 28 days of supplementation
Decision time will be assessed during the football-specific video decision-making task. It will be measured as the time taken to select a tactical response after the critical decision point. The outcome will be expressed in milliseconds, with lower values indicating faster decision-making.
Baseline and 28 days of supplementation
Impulsive Tactical Error Rate
Zeitfenster: Baseline and 28 days of supplementation
Impulsive tactical errors will be assessed during football-specific video clips. These errors will include selections of immediately attractive but suboptimal tactical options, such as inappropriate forward actions, low-quality shots, or forced progressive decisions when a safer or more appropriate option is available.
Baseline and 28 days of supplementation
Stroop/Flanker Time-on-Task Reaction-Time Trajectory
Zeitfenster: Baseline and 28 days of supplementation
Correct-trial reaction time will be assessed across six consecutive 5-minute epochs of the 30-minute high-load Stroop/Flanker task. Time-on-task performance decrement will be quantified from the within-session trajectory of reaction time across successive epochs, with a greater increase in reaction time indicating greater neurocognitive performance deterioration and a smaller increase indicating greater neurocognitive fatigue resistance. Response accuracy across epochs will be reported as a complementary measure.
Baseline and 28 days of supplementation
Stroop/Flanker Reaction-Time Variability
Zeitfenster: Baseline and 28 days of supplementation
Reaction-time variability will be assessed during the 30-minute high-load Stroop/Flanker task. It will be quantified from valid correct-trial reaction times as a within-participant measure of response-time variability and expressed in milliseconds, with greater variability indicating lower response stability.
Baseline and 28 days of supplementation
Post-Task Mental Fatigue
Zeitfenster: Baseline and 28 days of supplementation
Perceived mental fatigue will be assessed immediately before and immediately after the 30-minute neurocognitive-load task using a 0-10 numerical rating scale, with higher scores indicating greater perceived mental fatigue. The registered outcome will be the post-task mental-fatigue score assessed at baseline and after 28 days of supplementation. The acute pre-to-post task change will additionally be used as a manipulation check of the neurocognitive-load protocol.
Baseline and 28 days of supplementation
Time to First Fixation on the Optimal Tactical Area of Interest
Zeitfenster: Baseline and 28 days of supplementation
Time to first fixation on the optimal tactical option will be assessed using screen-based eye-tracking during the football-specific video decision-making task. The outcome will be expressed in milliseconds and will reflect how quickly the player visually orients toward the expert-defined optimal option.
Baseline and 28 days of supplementation
Dwell Time on the Optimal Tactical Area of Interest
Zeitfenster: Baseline and 28 days of supplementation
Dwell time on the optimal tactical option will be assessed using screen-based eye-tracking during the football-specific video decision-making task. The outcome will be expressed as the percentage of total viewing time spent fixating on the expert-defined optimal tactical option.
Baseline and 28 days of supplementation
Situational-Awareness Accuracy
Zeitfenster: Baseline and 28 days of supplementation
Situational awareness accuracy will be assessed using probes presented after selected football-specific video clips. These probes will evaluate whether players correctly identified key tactical information, including available space, pressure location, number of defenders, teammate positioning, and defensive-line configuration.
Baseline and 28 days of supplementation
Reactive Passing Decision-Selection Accuracy
Zeitfenster: Baseline and 28 days of supplementation
Reactive Passing Decision Test accuracy will be assessed during a field-based football-specific task. Players will dribble into a decision zone and respond to a late visual or situational cue by selecting and executing the optimal passing option. The outcome will be expressed as the percentage of accurate decisions.
Baseline and 28 days of supplementation

Mitarbeiter und Ermittler

Hier finden Sie Personen und Organisationen, die an dieser Studie beteiligt sind.

Sponsor

Vizja University in Warsaw

Mitarbeiter

Józef Piłsudski University of Physical Education

Studienaufzeichnungsdaten

Diese Daten verfolgen den Fortschritt der Übermittlung von Studienaufzeichnungen und zusammenfassenden Ergebnissen an ClinicalTrials.gov. Studienaufzeichnungen und gemeldete Ergebnisse werden von der National Library of Medicine (NLM) überprüft, um sicherzustellen, dass sie bestimmten Qualitätskontrollstandards entsprechen, bevor sie auf der öffentlichen Website veröffentlicht werden.

Haupttermine studieren

Studienbeginn (Tatsächlich)

6. August 2026

Primärer Abschluss (Tatsächlich)

8. September 2026

Studienabschluss (Tatsächlich)

8. September 2026

Studienanmeldedaten

Zuerst eingereicht

5. Juli 2026

Zuerst eingereicht, das die QC-Kriterien erfüllt hat

5. Juli 2026

Zuerst gepostet (Tatsächlich)

10. Juli 2026

Studienaufzeichnungsaktualisierungen

Letztes Update gepostet (Tatsächlich)

14. September 2026

Letztes eingereichtes Update, das die QC-Kriterien erfüllt

9. September 2026

Zuletzt verifiziert

1. September 2026

Mehr Informationen

Begriffe im Zusammenhang mit dieser Studie

Schlüsselwörter

Zusätzliche relevante MeSH-Bedingungen

Andere Studien-ID-Nummern

  • MIZERA -4-TCPS-FOOT-2026

Plan für individuelle Teilnehmerdaten (IPD)

Planen Sie, individuelle Teilnehmerdaten (IPD) zu teilen?

NEIN

Beschreibung des IPD-Plans

No individual participant data will be shared because the study includes a small sample of professional football players from a limited number of clubs, which may increase the risk of indirect participant identification. Only aggregated and anonymized study results will be reported.

Arzneimittel- und Geräteinformationen, Studienunterlagen

Studiert ein von der US-amerikanischen FDA reguliertes Arzneimittelprodukt

Nein

Studiert ein von der US-amerikanischen FDA reguliertes Geräteprodukt

Nein

Diese Informationen wurden ohne Änderungen direkt von der Website clinicaltrials.gov abgerufen. Wenn Sie Ihre Studiendaten ändern, entfernen oder aktualisieren möchten, wenden Sie sich bitte an register@clinicaltrials.gov. Sobald eine Änderung auf clinicaltrials.gov implementiert wird, wird diese automatisch auch auf unserer Website aktualisiert .

Abonnieren